TDMS Study 55301-05 Pathology Tables
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
Facility: TSI Mason Research
Chemical CAS #: 110-86-1
Lock Date: 12/15/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8|
| 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Pancreas | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Congestion | 2 1 2|
Developmental Malformation | |
Eosinophilic Focus | X X X X X X X X |
Fibrosis | 1|
Hepatodiaphragmatic Nodule | X X X X X|
Inflammation, Chronic Active | 1 1 2 1 1 3 |
Mitotic Alteration | 1 |
Mixed Cell Focus | X |
Necrosis | 2 1 1 1 |
Pigmentation | 2 1 3 |
Tension Lipidosis | X X X|
Vacuolization Cytoplasmic | 4 2 2 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Degeneration | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +|
Atrophy | 2 1 2 1 2 1 1 1 1 1 1 1 1|
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 |
Ulcer | 3 |
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8|
| 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 4 2 |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Inflammation, Chronic Active | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia | 1 1 1 1 |
Vacuolization Cytoplasmic | 1 2 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 3 3 4|
Pars Distalis, Cyst | 2 2 2 1 2 1 4 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 1 4 1 1 2 4 1 2 2 4 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 |
Duct, Ectasia | 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8|
| 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Fibrosis | 1 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Congestion | 2 |
Mediastinal, Congestion | 2 |
Mediastinal, Pigmentation | |
Renal, Congestion | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Ectasia | 1 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 2 3 3 |
Duct, Dilatation | 1 1 3 1 3 1 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 7| 3| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 7| 2| 4| 2| 9| 2| 8| 2| 2| 2| 9| 2| 2| 2| 9| 2| 2| 2| 2| 2| 3| 8|
| 9| 9| 2| 3| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 3| 9| 9| 9| 9| 9| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 3 4 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | 1 2 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2|
Mineralization | 1 2 |
Nephropathy | 2 2 1 1 2 1 1 2 2 2 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| |
| 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Pancreas | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 | 2 2.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 38 |
Clear Cell Focus | X X| 4 |
Congestion | 2 | 4 1.8|
Developmental Malformation | X | 1 |
Eosinophilic Focus | X X X X X X X X X X X | 19 |
Fibrosis | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X| 9 |
Inflammation, Chronic Active | 1 1 1 | 9 1.3|
Mitotic Alteration | | 1 1.0|
Mixed Cell Focus | X | 2 |
Necrosis | 1 1 | 6 1.2|
Pigmentation | 1 1 1 | 6 1.5|
Tension Lipidosis | | 3 |
Vacuolization Cytoplasmic | 2 2 1 1 2 | 10 1.8|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 20 1.0|
Centrilobular, Degeneration | 2 | 1 2.0|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis | 2 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 1 1 1 1 1 1 1| 22 1.1|
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| |
| 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 3.0|
Ulcer | 3 2 | 3 2.7|
Epithelium, Hyperplasia, Squamous | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 4 2 4 | 6 2.8|
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 1 1 2 2 2 1 2 1 1 1 1 1 1| 42 1.2|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 1 2 1 2 2 1 1| 11 1.3|
Vacuolization Cytoplasmic | 1 2 | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 3 3 2 | 11 2.7|
Pars Distalis, Cyst | 1 2 3 2 2 1 2 2| 16 2.0|
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 3 4 4 4 4 1 1 4 2 | 22 2.5|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 3 1 2 | 16 1.3|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| |
| 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 | 3 1.0|
Inflammation, Chronic Active | | 1 3.0|
Duct, Ectasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Cyst | 2 4 | 3 2.7|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 1 1 1 | 6 1.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3 | 1 3.0|
Fibrosis | | 1 1.0|
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Iliac, Congestion | 2 | 2 2.0|
Mediastinal, Congestion | 2 2 | 3 2.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Renal, Congestion | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 1.0|
Ectasia | 1 | 3 1.3|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Congestion | | 2 2.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Fibrosis | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Parathyroid Gland | X X | 2 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| |
| 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 3 | 3 2.7|
Hyperplasia | 1 2 | 5 2.2|
Duct, Dilatation | 4 4 1 1 3 2 | 13 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 4 | 2 3.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 1 2 2 3| 9 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1| 13 1.0|
Inflammation, Chronic | 2 1 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Inflammation, Chronic | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 1 3 3 2 2 1 2 | 15 1.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 9| 3| 3| 1| 8| 2| 2| 2| 2| 1| 3| 3| 3| 0| 6| 6| 7| 3| 3| 3| |
| 0| 0| 0| 0| 0| 6| 0| 0| 7| 8| 9| 9| 9| 9| 7| 0| 0| 0| 3| 1| 7| 1| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.0|
Mineralization | 1 | 3 1.3|
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 1 2 1 4 1 1 1 1 2 1| 41 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3|
| 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Congestion | |
Developmental Malformation | X X |
Eosinophilic Focus | X X X X X X X X X X X X|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic Active | |
Mixed Cell Focus | X X |
Necrosis | 3 |
Pigmentation | 1 |
Tension Lipidosis | X |
Vacuolization Cytoplasmic | 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 |
Centrilobular, Cytomegaly | |
Centrilobular, Degeneration | 2 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Inflammation, Acute | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 2 2 1 1|
Ectopic Liver | X X |
Hyperplasia | 4 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3|
| 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 3 2 3 |
Epithelium, Hyperplasia, Squamous | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 4 3 2 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 2 1 1 1 2 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hyperplasia | 1 2 1|
Vacuolization Cytoplasmic | 3 1 1 2 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 2 1 |
Necrosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 1 3 3 4|
Pars Distalis, Cyst | 2 2 3 2 2 2 2 2 |
Pars Distalis, Ectasia | 3 |
Pars Distalis, Hyperplasia | 3 4 4 3 1 4 1 4 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 2 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Duct, Ectasia | 2 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 4 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3|
| 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Dilatation | 4 |
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 1 3 |
Hyperplasia, Reticulum Cell | 3 |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Mediastinal, Congestion | |
Pancreatic, Pigmentation | |
Renal, Congestion | |
Renal, Ectasia | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Ectasia | 1 2 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | 2 |
Metaplasia, Osseous | |
Necrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 2 2 |
Hyperplasia | |
Duct, Dilatation | 2 1 1 2 3 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 9| 2| 2| 2| 3| 2| 2| 1| 3| 2| 3| 5| 2| 8| 2| 2| 2| 4| 2| 3| 3| 1| 3| 3|
| 9| 5| 9| 9| 9| 0| 9| 9| 7| 0| 9| 3| 0| 9| 8| 9| 9| 9| 6| 9| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 2 3 2 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic | 3 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Chronic Active | 3 1 3 3 1 1|
Nasolacrimal Duct, Cyst | 2 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Nephropathy | 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| |
| 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 1 | 2 1.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 28 |
Clear Cell Focus | X X X X | 9 |
Congestion | 2 | 1 2.0|
Developmental Malformation | | 2 |
Eosinophilic Focus | X X X X X X X X X X X X| 24 |
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 8 |
Inflammation, Chronic Active | 1 | 1 1.0|
Mixed Cell Focus | X X | 4 |
Necrosis | | 1 3.0|
Pigmentation | 2 | 2 1.5|
Tension Lipidosis | | 1 |
Vacuolization Cytoplasmic | 1 1 1 1 1 | 7 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.1|
Centrilobular, Cytomegaly | 1 | 1 1.0|
Centrilobular, Degeneration | | 2 2.5|
Centrilobular, Necrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 11 |
Fat, Necrosis | 2 2 2 2| 9 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 3 2 1 | 14 1.4|
Ectopic Liver | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| |
| 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 3 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 2 1.5|
Cytoplasmic Alteration | | 1 1.0|
Inflammation, Chronic | 1 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | | 3 2.7|
Epithelium, Hyperplasia, Squamous | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 3 1 1 2| 9 2.1|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Cyst | 3 | 1 3.0|
Hyperplasia | 2 1 1 1 2 1 2 1 1 | 12 1.3|
Vacuolization Cytoplasmic | 3 1| 8 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 7 1.7|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 1 | 9 2.6|
Pars Distalis, Cyst | 1 2 1 1 2 1 3 1 2 2 | 18 1.8|
Pars Distalis, Ectasia | | 1 3.0|
Pars Distalis, Hyperplasia | 1 1 2 1 1 2 3 4 1 3 1 3 4 2 2 1 2 1 | 29 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 1 | 3 1.7|
C-Cell, Hyperplasia | 1 1 1 1 3 1 2 2 1 1 | 17 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| |
| 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + M + + + + + + + + + + +| 48 |
Hyperplasia | | 2 2.5|
Inflammation, Acute | 2 | 2 2.5|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Duct, Ectasia | 3 1 | 5 2.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 4 3 | 7 3.6|
Hyperplasia | | 1 2.0|
Bilateral, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Cyst | 4 | 1 4.0|
Dilatation | | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
Hyperplasia | 1 1| 4 1.5|
Hyperplasia, Reticulum Cell | | 1 3.0|
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Mediastinal, Congestion | 1 | 1 1.0|
Pancreatic, Pigmentation | 2 | 1 2.0|
Renal, Congestion | 1 | 1 1.0|
Renal, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 1.0|
Ectasia | 3 | 4 1.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 3 2.0|
Hematopoietic Cell Proliferation | 1 1 1| 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| |
| 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 2| 2 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Parathyroid Gland | X | 1 |
Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 2 | 5 2.4|
Hyperplasia | 2 1 | 2 1.5|
Duct, Dilatation | 1 1 | 9 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Subcutaneous Tissue, Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 1 1 3 2 1 1 1 | 12 1.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 10 1.0|
Inflammation, Chronic | 1 1 2 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 3 1 1 1 3 3 | 15 1.8|
Nasolacrimal Duct, Cyst | 1 | 2 1.5|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 3| 2| 2| 2| 6| 7| 8| 2| 3| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 6| |
| 9| 9| 9| 9| 0| 9| 9| 9| 6| 0| 2| 9| 0| 9| 9| 9| 9| 9| 9| 9| 8| 2| 9| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
100 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 4 | 2 3.5|
Nephropathy | 1 1 1 1 1 2 1 1 1 3 1 2 1 1 1 1 1 1 2 3 2 | 42 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1|
| 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X X X X X X |
Congestion | |
Developmental Malformation | |
Eosinophilic Focus | X X X X X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | |
Necrosis | 1 |
Pigmentation | 1 |
Vacuolization Cytoplasmic | 4 1 1 2 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Cytomegaly | 1 1 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Ectopic Spleen | |
Fat, Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 3 1 1 |
Ectopic Liver | X |
Hyperplasia | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1|
| 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fibrosis | |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 4|
Ulcer | |
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 2 |
Mineralization | 2 |
Ulcer | 3 4 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 2 1 |
Vacuolization Cytoplasmic | 1 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Pars Distalis, Angiectasis | 3 3 4 2 2 2 3 |
Pars Distalis, Cyst | 2 2 2 2 3 2 2 2 1 3 |
Pars Distalis, Hyperplasia | 2 4 2 3 2 4 1 3 1 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 2 1 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 4|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1|
| 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Inflammation, Acute | |
Duct, Ectasia | 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
Pigmentation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Dilatation | |
Hyperplasia, Cystic | 2 1 1 |
Metaplasia, Squamous | |
Cervix, Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 |
Necrosis | |
Erythroid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + +|
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Congestion | |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 2 1 1 1 1 1 |
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 3 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 2 4 1|
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 1 |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 2 3 |
Inflammation, Chronic Active | 4 |
Duct, Dilatation | 2 2 1 1 1 2 4|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 2| 7| 0| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 2| 6| 2| 2| 8| 2| 9| 1|
| 1| 3| 7| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| 7| 9| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 1 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic | 1 1 2 |
Bronchiole, Alveolus, Hyperplasia | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 2 1 1 1 3|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 1 |
Mineralization | 1 1 1|
Nephropathy | 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| |
| 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 1.0|
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 1.7|
Basophilic Focus | X X X X X | 11 |
Clear Cell Focus | X X X | 11 |
Congestion | 2 2 3 | 3 2.3|
Developmental Malformation | X | 1 |
Eosinophilic Focus | X X X X X X X X X X X X| 22 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Chronic Active | 1 | 2 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 1 1.0|
Pigmentation | 3 3 4 1 2 | 6 2.3|
Vacuolization Cytoplasmic | 4 1 1| 9 1.8|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 34 1.0|
Centrilobular, Cytomegaly | 1 1 | 4 1.0|
Centrilobular, Degeneration | 1 2 | 2 1.5|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Ectopic Spleen | X | 1 |
Fat, Necrosis | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 1 1 | 13 1.2|
Ectopic Liver | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| |
| 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.5|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 3 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 3.5|
Ulcer | 3 3 3 3 | 4 3.0|
Epithelium, Hyperplasia, Squamous | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 4 3 1 2 2 2 | 9 2.4|
Mineralization | 1 | 2 1.5|
Ulcer | 2 | 3 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 1 1 1 2 1 1 2 2 1 1 1 2 2 1 1 1| 43 1.2|
Thrombosis | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Hyperplasia | 2 1 2 1 1 1| 9 1.3|
Vacuolization Cytoplasmic | 3 2 | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 2 4 2 | 8 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | 2 | 1 2.0|
Pars Distalis, Angiectasis | 2 2 2 4 2| 12 2.6|
Pars Distalis, Cyst | 2 2 3 3 2 2 2 2 2 1 | 20 2.1|
Pars Distalis, Hyperplasia | 4 1 2 1 4 2 2 1 2 2 | 21 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| |
| 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 1 1 1 2 4 | 13 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3| 1 3.0|
Inflammation, Chronic | 1 1 | 5 1.0|
Inflammation, Chronic Active | | 2 3.0|
Bilateral, Inflammation, Acute | 4 | 1 4.0|
Duct, Ectasia | 3| 4 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 4 3.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Dilatation | 4 | 1 4.0|
Hyperplasia, Cystic | 1 1 | 5 1.2|
Metaplasia, Squamous | 2 | 1 2.0|
Cervix, Hypertrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 | 2 3.0|
Necrosis | 2 | 1 2.0|
Erythroid Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 15 |
Mediastinal, Congestion | 2 3 2 3 | 4 2.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Congestion | 3 | 1 3.0|
Renal, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Ectasia | 1 1 | 9 1.1|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 | 3 2.0|
Ectasia | 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| |
| 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 4 | 2 3.5|
Fibrosis | | 3 2.3|
Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Cyst | | 1 1.0|
Ectopic Parathyroid Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 3.0|
Hyperplasia | 3 1 2 3 | 6 2.3|
Inflammation, Chronic Active | | 1 4.0|
Duct, Dilatation | 1 2 1 1 4 1 | 13 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 2 4.0|
Hyperplasia, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 2 4 4 1 2 1 | 10 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 | 9 1.1|
Inflammation, Chronic | 1 1 1 | 6 1.2|
Bronchiole, Alveolus, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | 2 2 1 3 4 1 3 1 1| 16 1.8|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 6| 7| 6| 6| 7| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 0| 9| 2| 2| 2| 1| 0| 2| 6| 2| 2| 7| 9| 2| 8| 2| 2| 0| 8| 2| 2| |
| 9| 9| 9| 9| 7| 8| 9| 1| 9| 1| 5| 9| 1| 4| 9| 1| 9| 9| 0| 9| 9| 0| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Cyst | | 1 1.0|
Mineralization | 2 | 4 1.3|
Nephropathy | 2 2 1 1 2 2 1 1 1 2 2 2 3 1 1 1 1 1 1| 35 1.3|
Pigmentation | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1| 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1|
| 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Clear Cell Focus | X X X X X X X X X X X |
Congestion | 2 2 |
Eosinophilic Focus | X X X X X X X X 2 X X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic Active | 1 1 |
Mitotic Alteration | |
Mixed Cell Focus | X X X X X |
Pigmentation | 2 1 1 1 1 1 2 1 3 3 |
Vacuolization Cytoplasmic | 2 3 3 1 2 1 1 1 2 1 2 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Capsule, Inflammation, Chronic | |
Centrilobular, Cytomegaly | 1 2 1 1 1 2 2 1 1 1 1 |
Centrilobular, Degeneration | 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation | |
Fat, Necrosis | 2 2 2 2 2|
__________________________________________________________________________|
Oral Mucosa | + + |
Pharyngeal, Hyperplasia | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 2 2 1 1 |
Ectopic Liver | X |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Ulcer | 3|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1|
| 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia, Squamous | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hyperplasia | 4 1 |
Vacuolization Cytoplasmic | 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 1 2 3 2 |
Pars Distalis, Hyperplasia | 1 2 1 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 2 3 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active | |
Vacuolization Cytoplasmic | |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1|
| 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 3 2 |
Hemorrhage | |
Hyperplasia, Cystic | 4 1 1 2 2 |
Hyperplasia | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | |
Necrosis | |
Cervix, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Iliac, Ectasia | 2 |
Mediastinal, Congestion | |
Mediastinal, Pigmentation | |
Renal, Ectasia | |
Renal, Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
Edema | 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 2 1 2|
Hematopoietic Cell Proliferation | 3 |
Necrosis | 2|
Pigmentation | |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 7| 5| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 2| 2| 0| 2| 5| 3| 2| 2| 8| 2| 2| 0| 0| 2| 2| 2| 2| 2| 2| 2| 1|
| 9| 1| 6| 3| 9| 9| 3| 9| 7| 0| 9| 9| 9| 9| 9| 5| 8| 9| 9| 9| 9| 9| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia | |
Duct, Dilatation | 1 2 1 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Inflammation, Chronic | 1 1 3 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 3 1 1 2 2 1 3 1 1 1 2 |
Respiratory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 2 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Inflammation, Acute | 3 |
Mineralization | 1 1 1 1 |
Nephropathy | 1 1 1 3 1 1 1 1 1 1 1 1 1 2 2 1 1 1 |
Pigmentation | 1 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| |
| 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 5 2.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Clear Cell Focus | X X X X X| 16 |
Congestion | | 2 2.0|
Eosinophilic Focus | X X X X| 15 2.0|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Chronic Active | 1 1 | 4 1.0|
Mitotic Alteration | 2 | 1 2.0|
Mixed Cell Focus | | 5 |
Pigmentation | 2 1 2 2 1 2 1| 17 1.6|
Vacuolization Cytoplasmic | 1 1 1 2 2 1| 18 1.6|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
Capsule, Inflammation, Chronic | 2 2 | 2 2.0|
Centrilobular, Cytomegaly | 2 2 1 2 2 1 2 1 1| 20 1.4|
Centrilobular, Degeneration | 1 1 1 1| 7 1.1|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Inflammation | 3 | 1 3.0|
Fat, Necrosis | 1 2 2 2 2 2 | 11 1.9|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Pharyngeal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1| 14 1.1|
Ectopic Liver | X X | 3 |
Inflammation, Chronic | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| |
| 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 2 2 3 | 4 2.5|
Epithelium, Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 2 4 2 1 | 7 2.1|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Epithelium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 36 1.1|
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Cyst | 3 | 1 3.0|
Hyperplasia | 1 1 1 2 | 6 1.7|
Vacuolization Cytoplasmic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 1 2 | 4 1.8|
Pars Distalis, Cyst | 2 2 2 | 8 2.1|
Pars Distalis, Hyperplasia | 1 2 2 4 2 3 4 4 3 2 1| 18 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 1 1 1 1 | 10 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| |
| 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2| 2 2.5|
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
Duct, Ectasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 2 1.5|
Inflammation, Chronic | 3 | 1 3.0|
Bilateral, Cyst | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Dilatation | | 2 2.5|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Cystic | 1 1 | 7 1.7|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Cervix, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 | 2 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 19 |
Iliac, Ectasia | 2 | 2 2.0|
Mediastinal, Congestion | 1 | 1 1.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
Renal, Ectasia | 1 | 1 1.0|
Renal, Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1| 2 1.0|
Edema | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| |
| 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Fibrosis | 3 | 4 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Necrosis | | 1 2.0|
Pigmentation | 2 | 1 2.0|
Capsule, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Parathyroid Gland | X X | 2 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 1 2 2 | 5 2.0|
Duct, Dilatation | 1 2 1 1 1 1 2 1 | 13 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 1 2 3 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1| 11 1.0|
Inflammation, Chronic | 2 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 3 3 2 3 2 1 1 2 | 19 1.8|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 3| 7| 6| 6| 6| 6| 7| 6| 6| 6| 5| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| |
DAY ON TEST | 7| 2| 3| 8| 2| 0| 4| 2| 2| 2| 0| 8| 3| 8| 9| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| |
| 2| 9| 9| 0| 9| 3| 9| 5| 8| 9| 5| 7| 4| 3| 2| 9| 9| 9| 1| 9| 9| 9| 4| 6| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Inflammation, Acute | | 1 3.0|
Mineralization | 1 1 | 6 1.0|
Nephropathy | 1 2 2 3 1 1 1 1 2 2 1 2 1 2 1 1 1 1 1| 37 1.3|
Pigmentation | | 1 1.0|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3|
DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0|
| 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Congestion | |
Degeneration, Cystic | 1 3 |
Eosinophilic Focus | X X X X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Necrosis | 1 |
Pigmentation | 1 1 |
Vacuolization Cytoplasmic | 3 1 1 |
Bile Duct, Hyperplasia | 1 2 1 1 3 1 1 2 1 1 1 2 1 3 1 1 3 1 3 3 1 1 |
Centrilobular, Degeneration | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Cyst | 2 |
Fat, Necrosis | 3 3 2 2 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 2 1 1 1 2 |
Cytoplasmic Alteration | |
Hyperplasia | 4 |
Inflammation, Chronic | |
Artery, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 |
Ulcer | 3 |
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3|
DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0|
| 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 4 4 2 2 4 2 2 2 1 3 1 |
Inflammation, Chronic | 2|
Ulcer | 2 2 |
__________________________________________________________________________|
Tooth | + + |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 1 2 2 1 3 2 2 1 2 1 2 2 1 1 1 1|
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Hyperplasia | 2 1 1 1 1 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 3 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 3 3 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 4 1 2 4 4 3 2 1 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1|
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3|
DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0|
| 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 4 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 1 1 1 2|
Inflammation, Chronic Active | 2 2 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 3 |
Inflammation, Chronic Active | 3 3 2 3 1 3 2 1 1 2 1 2 1 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Necrosis | 4 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 4 1 |
Interstitial Cell, Hyperplasia | 4 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Iliac, Infiltration Cellular, Plasma | |
Cell | 4 |
Mediastinal, Hemorrhage | |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Fibrosis | 4 3 3 2 2 3 |
Hematopoietic Cell Proliferation | |
Necrosis | 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | |
Duct, Dilatation | 4 4 2 1 3 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 6| 7| 7| 6| 5| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 7| 3|
DAY ON TEST | 9| 9| 1| 4| 1| 2| 0| 2| 2| 0| 9| 8| 1| 2| 7| 1| 2| 2| 6| 2| 2| 0| 7| 2| 0|
| 5| 2| 9| 0| 8| 2| 4| 2| 2| 2| 5| 8| 9| 2| 9| 8| 2| 2| 7| 2| 2| 1| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 1 2 2 2 2 2 1 1 2 1 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Developmental Malformation | |
Hydronephrosis | 2 |
Nephropathy | 4 3 1 2 2 3 3 2 1 2 1 3 3 1 3 2 3 2 3 2 2 2 1|
Artery, Inflammation, Acute | |
Artery, Inflammation, Chronic Active | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X | 12 |
Clear Cell Focus | X X X X | 7 |
Congestion | 2 | 1 2.0|
Degeneration, Cystic | 1 1 | 4 1.5|
Eosinophilic Focus | X X X X X X X| 14 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Hepatodiaphragmatic Nodule | X | 3 |
Mixed Cell Focus | X | 2 |
Necrosis | 1 | 2 1.0|
Pigmentation | 1 1 | 4 1.0|
Vacuolization Cytoplasmic | 1 | 4 1.5|
Bile Duct, Hyperplasia | 1 1 1 1 3 1 1 1 1 3 1 1 2 1 2 1 1 1 1 1 1 1 1 1| 46 1.4|
Centrilobular, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + +| 11 |
Cyst | | 1 2.0|
Fat, Necrosis | 2 2 2| 10 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 1 1 1 1 1 1 1 1 | 18 1.3|
Cytoplasmic Alteration | 1 1 | 2 1.0|
Hyperplasia | 1 | 2 2.5|
Inflammation, Chronic | 3 | 1 3.0|
Artery, Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 3.0|
Ulcer | 3 | 2 3.0|
Epithelium, Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 4 4 1 3 | 15 2.6|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 2 2 3 2 2 2 1 3 1 3 2 1 1 2 1 1 1 2 2 2| 45 1.7|
Mineralization | 2 | 1 2.0|
Thrombosis | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Hyperplasia | 2 2 | 8 1.5|
Hypertrophy | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 2 1 1 3 2 | 9 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 1 1 2 1 2 3 2 2 2 2| 17 2.2|
Bilateral, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 1 3 1 1 1 1 2 4 3 2 1 4| 22 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 2 1 | 7 1.1|
Follicle, Dilatation | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hyperplasia | 2 3 | 4 2.8|
Inflammation, Acute | 4 | 2 3.0|
Inflammation, Chronic | 1 1 2 2 1 2 1 1 1 1 1 | 17 1.3|
Inflammation, Chronic Active | 2 | 5 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Acute | 3 | 2 3.5|
Inflammation, Chronic | | 2 2.0|
Inflammation, Chronic Active | 3 2 2 1 2 1 2 2 2 1 1 1 1 1 1| 31 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Atrophy | | 2 2.5|
Necrosis | | 1 4.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 3 2.3|
Interstitial Cell, Hyperplasia | 2 3 2 2 1 2 1 | 9 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 20 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Infiltration Cellular, Plasma | | |
Cell | | 1 4.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Renal, Congestion | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2| 4 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Ectasia | 1 | 2 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 1 2 2 2 2 2 2| 14 2.3|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
Duct, Dilatation | 3 4 1 1 1 3 3 2 | 14 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 2 3.0|
Osteopetrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1| 6 1.0|
Inflammation, Chronic | 1 2 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 2 3 2 3 4 2 1 2 3 3 3| 26 2.2|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 7| 6| 6| 4| 7| 7| 5| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 4| 2| 2| 7| 2| 5| 6| 3| 2| 2| 7| 1| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 5| 2| 4| 2| 2| 1| 2| 6| 7| 4| 2| 2| 4| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 | 3 2.7|
Developmental Malformation | X X | 2 |
Hydronephrosis | 1 1 | 3 1.3|
Nephropathy | 2 2 2 2 2 2 4 2 4 1 2 3 3 3 3 1 3 2 1 1 3 2 4 2| 47 2.3|
Artery, Inflammation, Acute | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1|
| 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 1 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | |
Degeneration, Cystic | 4 2 3 2 2 2 1 |
Eosinophilic Focus | X X X X X X X X X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 1 2 2 1 1 |
Vacuolization Cytoplasmic | 3 3 |
Bile Duct, Hyperplasia | 3 1 3 2 3 2 1 1 3 2 1 1 1 1 1 1 1 3 2 1 2 1|
Centrilobular, Cytomegaly | 2 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Acute | |
Fat, Necrosis | 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 2 1 3 3 2 1 |
Hyperplasia | 1 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Ulcer | 2 4 4 4 4 4 4 3 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1|
| 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia, Squamous | 3 3 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 3 2 2 3 3 4 2|
Inflammation, Chronic | |
Mineralization | |
Ulcer | 3 3 3 4 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 1 1 1 2 2 2 2 2 2 1 2 2 2 2 2 3 3 2 1|
Thrombosis | 3 3 3|
Coronary Artery, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Vacuolization Cytoplasmic | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 4 1 4 4 4 2 1 1 1 2 3|
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | 1 2 2 1|
Pars Distalis, Ectasia | |
Pars Distalis, Hyperplasia | 3 3 1 1 3 1 2 4 3 3 2 |
Pars Distalis, Thrombosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 3 1 1 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 2 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1|
| 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1|
Inflammation, Chronic Active | 2 1 1 1 1 2 2 4 1 |
Duct, Dilatation | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 2 |
Hyperplasia, Focal | |
Inflammation, Acute | 3 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 3 2 2 2 1 1 4 2 2 2 2 2 1 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 1 |
Interstitial Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 2 2 2 |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | 2 2|
Mediastinal, Hemorrhage | 2 |
Renal, Fibrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Ectasia | 3 2 |
Hemorrhage | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 3 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1|
| 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Concretion | 2 |
Hyperplasia | 2 |
Duct, Dilatation | 2 2 1 3 2 3 4 1 1 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 2 1 1 |
Inflammation, Chronic | 2 2 1 2 1 1 2 1|
Alveolar Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic Active | 1 1 1 3 1 2 1 2 3 3 2 |
Squamous Epithelium, Nasolacrimal | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 4| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 6| 6| 6| 6| 7|
DAY ON TEST | 2| 6| 4| 2| 2| 6| 2| 2| 9| 6| 2| 4| 2| 2| 2| 8| 6| 2| 9| 0| 2| 0| 6| 6| 1|
| 2| 6| 1| 2| 2| 6| 2| 2| 8| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 0| 8| 7| 6| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | |
Nephropathy | 2 3 2 2 2 1 2 3 3 2 1 2 2 3 3 4 4 3 1 2 2 2 2 1 2|
Capsule, Hemorrhage, Chronic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| |
DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| |
| 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 |
Edema | 4 | 1 4.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
Edema | 4 | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
Hyperplasia, Lymphoid | 3 2 1 2 | 9 1.9|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X X X | 5 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic | 3 3 3 1 2 | 12 2.3|
Eosinophilic Focus | X X X X X X X X X X X | 23 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | X | 1 |
Necrosis | 1 | 1 1.0|
Pigmentation | 1 1 1 1 2 1 | 11 1.3|
Vacuolization Cytoplasmic | 2 1 1 1 | 6 1.8|
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 3 1 2 3 3 1 1 1 1| 43 1.5|
Centrilobular, Cytomegaly | 1 1 1 | 4 1.3|
Centrilobular, Degeneration | 2 3 2 | 3 2.3|
Centrilobular, Necrosis | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 14 |
Inflammation, Acute | 2 | 1 2.0|
Fat, Necrosis | 2 2 3 2 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 |
Atrophy | 1 2 1 2 1 | 15 1.7|
Hyperplasia | 2 2 | 4 1.8|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| |
DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| |
| 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Inflammation, Acute | | 1 4.0|
Ulcer | 3 2 | 10 3.4|
Epithelium, Hyperplasia, Squamous | 3 3 1 3 | 7 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Erosion | 4 2 4 2 4 2 4 2| 17 2.6|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 2 2 | 2 2.0|
Ulcer | 3 | 5 3.2|
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 2 1 2 1 1 2 3 2 2 2 2 2 1 1 1 2 | 43 1.7|
Thrombosis | 3 2 3 | 6 2.8|
Coronary Artery, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia | 1 1 2 3 | 7 1.9|
Vacuolization Cytoplasmic | 1 4 1| 5 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia | 2 3 4 1 2 4 4 | 22 2.3|
Bilateral, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 |
Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 2 3.5|
Pars Distalis, Cyst | 2 1 1 1 | 8 1.4|
Pars Distalis, Ectasia | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 1 4 4 4 4 | 16 2.7|
Pars Distalis, Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| |
DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| |
| 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation | 1 | 1 1.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 | 5 1.4|
Follicle, Dilatation | | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + M + + + + + + + M + + + + +| 47 |
Hyperplasia | | 3 2.3|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | 25 1.1|
Inflammation, Chronic Active | 2 2 4 2 1| 14 1.9|
Duct, Dilatation | | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + M + + + M + + + + +| 48 |
Hemorrhage, Chronic | | 1 2.0|
Hyperplasia, Focal | 1 | 1 1.0|
Inflammation, Acute | | 2 3.5|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 2 1 3 1 2 2 3 4 2 1 4 1 | 29 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | 4 | 2 2.5|
Interstitial Cell, Hyperplasia | 1 3 1 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | | 4 2.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 25 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | 2 2 2 | 5 2.0|
Mediastinal, Hemorrhage | | 1 2.0|
Renal, Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| |
DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| |
| 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Ectasia | 2 2 | 3 1.7|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
Congestion | 4 | 2 3.0|
Ectasia | 3 | 3 2.7|
Hemorrhage | | 1 2.0|
Necrosis | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 |
Congestion | | 1 3.0|
Fibrosis | 2 1 3 3 | 11 2.1|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | 2 | 2 2.5|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 | 1 2.0|
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Concretion | | 1 2.0|
Hyperplasia | 1 1 | 3 1.3|
Duct, Dilatation | 1 3 4 3 | 16 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 4 | 1 4.0|
Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 1 3.0|
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 4| 6| 6| 7| 5| 4| 6| |
DAY ON TEST | 2| 3| 2| 0| 2| 0| 0| 0| 2| 2| 2| 1| 2| 2| 6| 6| 2| 2| 4| 7| 7| 2| 5| 5| 2| |
| 2| 8| 2| 4| 2| 4| 8| 1| 2| 2| 2| 8| 2| 5| 7| 4| 2| 2| 4| 7| 3| 2| 3| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 | 4 1.3|
Inflammation, Chronic | 1 1 | 10 1.4|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Inflammation, Chronic Active | 3 3 4 3 2 1 1 | 18 2.1|
Squamous Epithelium, Nasolacrimal | | |
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + M + + + M + + + + + + + + +| 48 |
Cyst | 3 | 3 2.7|
Hydronephrosis | 1 | 1 1.0|
Nephropathy | 2 1 3 3 2 1 1 2 3 3 4 3 1 3 3 4 1 2 2 3 2 1 | 47 2.3|
Capsule, Hemorrhage, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + M + + + M + + + + +| 47 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2|
| 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Pancreas | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 1 2 1 1 2 1 4|
Developmental Malformation | X |
Eosinophilic Focus | X X X X X X X X X X X X|
Fibrosis | 1 |
Mixed Cell Focus | X X |
Necrosis | |
Pigmentation | 1 1 3 2 2 1 2 1 1 2 1 1 |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 1 1 2 1 1 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 3 1 3 2 3 3 1 3 3 1 1 3 1 3 1 1 1 2|
Centrilobular, Cytomegaly | 1 1 1 |
Centrilobular, Degeneration | 1 3 |
Periportal, Fibrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | 3 |
Fat, Necrosis | 1 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 1 1 1 1 1 |
Hyperplasia | 2 3 |
Inflammation, Chronic | 1 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia, Squamous | 4 4 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2|
| 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 3 4 2 |
Inflammation, Chronic Active | |
Mineralization | 2 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 2 1 3 2 2 1 2 1 2 2 1 2 2 2 2 2|
Mineralization | 3 2 |
Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia | 1 4 1 1 2 2 |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 1 4 4 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 4 4 1 1 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
Inflammation, Chronic | 2 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2|
| 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 4 1 1 2 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 3 2 2 1 2 1 3 1 1 1 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 3 |
Interstitial Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Ectasia | 2|
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 2|
Pancreatic, Congestion | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Necrosis | 3 |
Pancreatic, Pigmentation | |
Renal, Congestion | |
Renal, Edema | 4 |
Renal, Hyperplasia, Lymphoid | 1 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Fibrosis | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | 1 2|
Hyperplasia, Focal | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2|
| 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 1 1 |
Duct, Dilatation | 3 2 1 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | 4|
Hyperplasia, Squamous | 2|
Necrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 2 |
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic | 1 2 2 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 2 3 3 1 3 1 1 3 2 3 3 |
Nasolacrimal Duct, Cyst | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 3 3 4 2 3 |
Nephropathy | 2 4 3 2 2 2 3 2 3 2 3 2 1 4 2 4 1 3 3 3 2 3 3 2 3|
Renal Tubule, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 55301-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 10:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 2| 7| 7| 6| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 2| 2| 2| 9| 4| 2| 2| 2| 8| 0| 2| 7| 6| 0| 2| 6| 0| 2| 3| 2| 2|
| 2| 2| 2| 9| 2| 2| 2| 6| 4| 2| 2| 2| 0| 8| 5| 9| 9| 0| 2| 9| 0| 2| 4| 2| 2|
________________________________________________________________________________________