TDMS Study 55301-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research PYRIDINE DATE: 10/08/97
EXPERIMENT: 55301 TEST: 05 TIME: 11:20:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES95268 ROUTE: DOSED WATER NTP C#: 55301B
PATHOLOGIST: P. HILDEBRANDT CAS: 110-86-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research PYRIDINE DATE: 10/08/97
EXPERIMENT: 55301 TEST: 05 TIME: 11:20:59
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES95268 ROUTE: DOSED WATER NTP C#: 55301B
PATHOLOGIST: P. HILDEBRANDT CAS: 110-86-1
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 309 388 388 434 473 571 574 579 595 602 |
| 604 625 640 644 656 667 667 692 695 701 |
| 715 718 718 719 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 444 455 466 538 553 598 604 604 607 618 |
| 620 625 628 641 642 664 665 665 666 666 |
| 666 667 673 677 682 698 700 701 708 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 269 486 525 529 534 538 580 585 589 596 |
| 609 627 632 640 644 648 648 662 669 673 |
| 679 700 700 708 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 194 428 444 465 515 520 523 543 562 584 |
| 598 601 616 622 627 634 644 647 647 651 |
| 670 672 675 676 681 685 691 691 697 697 |
| 700 717 719 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 722 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 722 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.0 94.0 90.0 90.0 78.0 70.0 50.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 94.0 92.0 84.0 64.0 40.0 |
| | |
| | |
|200 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 88.0 80.0 64.0 50.0 |
| | |
| | |
|400 PPM | 100.0 100.0 98.0 98.0 98.0 92.0 84.0 76.0 60.0 32.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.0% 40.0% 50.0% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.124 P=0.403 P=1.000 P=0.095 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.7 628.6 607.6 610.4 |
|NATURAL DEATHS (C) | (23.6) (13.3) (19.0) (18.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 662.9 666.0 664.8 646.1 |
|(STANDARD ERROR) | (14.4) (10.3) (12.5) (14.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 399 493 503 588 596 622 636 649 661 667 |
| 671 673 681 687 696 717 717 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 488 533 546 570 611 642 650 666 666 682 |
| 695 717 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 496 521 549 561 573 580 586 605 624 665 |
| 671 687 698 699 700 703 707 707 711 718 |
| 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 380 457 503 511 583 584 589 603 605 608 |
| 616 625 628 634 636 639 641 649 672 673 |
| 687 692 705 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 82.0 64.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 86.0 74.0 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 84.0 80.0 58.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 82.0 64.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 74.0% 58.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.055 P=0.392N P=0.700 P=0.204 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.1 630.3 642.0 609.6 |
|NATURAL DEATHS (C) | (20.7) (20.9) (15.9) (16.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.1 703.3 692.5 671.7 |
|(STANDARD ERROR) | ( 9.9) ( 8.1) ( 9.0) (11.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PYRIDINE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 4 3 1 1 4 2 2 3
| 1 1 4 2 2 3 332
| 1 41 4 32 2
90 + 1 4 4 2 1 2
| 3 3 22
P | 4 4 4113 1
E | 4 4 112 2
R 80 + 4 11
C | 1 21
E | 4 44131
N | 44 1 1
T 70 + 44231 21
| 44
S | 43 21 11
U | 33 11
R 60 + 4 4 1 1
V | 3 3
I | 22 3 3
V | 22 33
A 50 + 2 2 11
L | 44
| 4222
| 22
40 + 22
| 4 4
|
| 44
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 43 obs hidden.
PYRIDINE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 4 1 23
| 4 1 4 21 3 2
96 + 4 11 3 223
| 14 23 32 1
P | 4 32 1 1 2
E | 33 1 21 2
R 88 + 33 4 1 122
C | 3 4 3 1 1 2
E | 3 3 1 1
N | 3 11 2
T 80 + 44 33 2 2
| 4 4 11 32 2
S | 1133 22
U | 44 11 2 2
R 72 + 11
V | 44 13 1
I |
V | 44 11
A 64 + 4 4 33 1 1
L | 44 33
| 4 4
| 3 3
56 + 4 4
| 44
| 4 4
|
48 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.