TDMS Study 55301-06 Pathology Tables
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
Facility: TSI Mason Research
Chemical CAS #: 110-86-1
Lock Date: 12/13/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 8| 2| 5| 2| 5| 2| 7| 2| 2| 2| 2| 2| 6| 0| 2| 2| 2| 2| 1| 2| 0| 2| 4| 1| 0|
| 9| 2| 7| 2| 4| 2| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 2| 2| 7| 2| 7| 2| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + A + + + + + + + + A + + + + A + A + A A A|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + A + A + + A A|
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + + + + + + A + + + + A + M + A A A|
Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + A + A + A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + A + A + A A A|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + A + + + + + + + + A + + + + A + A + A A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X X X X X X X X X X X |
Congestion | 3 2 3 3 4 2 4 3 4|
Degeneration, Cystic | 2 |
Eosinophilic Focus | X X X X X X X X |
Fibrosis | 2 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Acute | |
Mixed Cell Focus | |
Necrosis | |
Pigmentation | 1 3 |
Vacuolization Cytoplasmic | 1 1 1 4 1 1 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 3 1 1 1 1 1 2 1 2 1 |
Centrilobular, Degeneration | |
Centrilobular, Necrosis | 3 2 3 3 |
Hepatocyte, Atrophy | |
Oval Cell, Hyperplasia | |
Sinusoid, Congestion | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Mineralization | 2 |
Artery, Inflammation | 4 3 2 4 |
Artery, Mineralization | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + + + + |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + A + A + +|
Atrophy | 1 |
Basophilic Focus | X |
Hyperplasia | 4 3 3 3 4 4 4 4 |
Necrosis | 1|
Acinus, Hyperplasia | |
Artery, Inflammation | 3 |
Artery, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 8| 2| 5| 2| 5| 2| 7| 2| 2| 2| 2| 2| 6| 0| 2| 2| 2| 2| 1| 2| 0| 2| 4| 1| 0|
| 9| 2| 7| 2| 4| 2| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 2| 2| 7| 2| 7| 2| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Artery, Mineralization | 3 |
Duct, Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | 3 |
Inflammation, Acute | |
Mineralization | |
Ulcer, Chronic | 4 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Erosion | 2 |
Hyperplasia | |
Mineralization | 3 4 2 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
Peridontal Tissue, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Mineralization | 2 4 |
Aorta, Mineralization | 3 4 2 |
Pulmonary Artery, Mineralization | 4 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 2 2 2 2 2 2 3 3 1 4 2 2 3 1 4 3 3 1 4 3|
Inflammation, Chronic | |
Mineralization | 1 2 1 |
Thrombosis | 2 |
Artery, Mineralization | 2 |
Artery, Thrombosis | |
Atrium, Thrombosis | 4 2 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Angiectasis | 2|
Hemorrhage | 2 2 3 |
Hyperplasia | 4 |
Hypertrophy | 1 2|
Vacuolization Cytoplasmic | 2 1 2 1 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 8| 2| 5| 2| 5| 2| 7| 2| 2| 2| 2| 2| 6| 0| 2| 2| 2| 2| 1| 2| 0| 2| 4| 1| 0|
| 9| 2| 7| 2| 4| 2| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 2| 2| 7| 2| 7| 2| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + A + A + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +|
Hyperplasia | 4 4 4 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 2 3 2 2|
Hyperplasia | 3 3 1 3 2 2 1 |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 2 2 3 4 4 |
Duct, Cyst | 2 2 3 2 2 2 2 1 3 1 2 4 1 1 3 4 3 2 2 2 2 1 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 2 1 1 1 |
Inflammation, Acute | 2 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 2 |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 1 4 1 1 4 |
Mineralization | 1 1 1 |
Artery, Inflammation | 2 2 2 2 3 1 4 3|
Interstitial Cell, Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 8| 2| 5| 2| 5| 2| 7| 2| 2| 2| 2| 2| 6| 0| 2| 2| 2| 2| 1| 2| 0| 2| 4| 1| 0|
| 9| 2| 7| 2| 4| 2| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 2| 2| 7| 2| 7| 2| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | 2 2 |
Hemorrhage | 2 3 |
Hyperplasia, Plasma Cell | 3 |
Iliac, Ectasia | 3 3 |
Iliac, Hemorrhage | 2 |
Inguinal, Atrophy | 2 |
Inguinal, Ectasia | 2 |
Mediastinal, Congestion | 2 |
Mediastinal, Ectasia | 1 2 2 2 |
Mediastinal, Hemorrhage | 1 4 4 2 |
Pancreatic, Ectasia | 4 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Plasma Cell | |
Renal, Ectasia | 4 4 3 3 3 2 3|
Renal, Hemorrhage | 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Ectasia | 2 2 2 2 1 1 1 2 2 |
Hemorrhage | 4 |
Hyperplasia, Plasma Cell | 3 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + M A + + + + + + + + + + +|
Ectasia | 1 1 2 |
Hemorrhage | 2 2 3 1 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
Angiectasis | |
Atrophy | 3 2 |
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Necrosis | 1 |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | 3 4 4 4 4 2|
Cyst | 2 |
Ectopic Parathyroid Gland | 2 2 |
Ectopic Thyroid | |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 1|
Artery, Mineralization | 1 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 8| 2| 5| 2| 5| 2| 7| 2| 2| 2| 2| 2| 6| 0| 2| 2| 2| 2| 1| 2| 0| 2| 4| 1| 0|
| 9| 2| 7| 2| 4| 2| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 2| 2| 7| 2| 7| 2| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Dilatation | 1 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperkeratosis | |
Inflammation, Chronic | 3 |
Ulcer | 4 |
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 4 3 2 |
Cranium, Fibrous Osteodystrophy | 3 4 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 1 1 |
Necrosis | 4 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 4 |
Alveolus, Mineralization | 1 |
Artery, Mineralization | 1 |
Bronchus, Inflammation, Acute | |
Bronchus, Mineralization | 1 |
Interstitium, Fibrosis | 3 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Erosion | 2 |
Foreign Body | X X X X |
Hemorrhage | 3 3 |
Hyperplasia, Squamous | 3 |
Inflammation, Acute | 1 1 4 |
Inflammation, Chronic | 3 2 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 8| 2| 5| 2| 5| 2| 7| 2| 2| 2| 2| 2| 6| 0| 2| 2| 2| 2| 1| 2| 0| 2| 4| 1| 0|
| 9| 2| 7| 2| 4| 2| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 2| 2| 7| 2| 7| 2| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Olfactory Epithelium, Hyperplasia | 3 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 1 2 1 2 1 1 1 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Cyst | 2 2 2 2 2 1 2 1 1 2|
Hydronephrosis | 2 2 |
Mineralization | 1 2 2 |
Nephropathy | 1 3 4 3 3 4 2 4 3 3 2 3 4 4 4 3 2 3 4 3 4 3 4 4 4|
Artery, Mineralization | 2 2 2 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + A A + + + + + + A + + + A A + A| 35 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + A + + + + + + +| 42 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + A A + A + + A + A + + A A A + A| 32 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A A + + + + + + A + + + A A + +| 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + + A A + + + + + + + + + + A A + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + A + A + + A A + A A + A + A A + + A A + +| 28 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 1 | 5 1.6|
Clear Cell Focus | X X X X | 15 |
Congestion | 3 2 2 2 2 2 2 3 2 3| 19 2.7|
Degeneration, Cystic | 1 1 1 3 2 3 | 7 1.9|
Eosinophilic Focus | X X X X X X | 14 |
Fibrosis | | 1 2.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Acute | 1 | 1 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | 1 3 1 1 1 3 | 6 1.7|
Pigmentation | 1 2 1 1 | 6 1.5|
Vacuolization Cytoplasmic | 1 1 1 1 1 3 1 2 2 3 | 18 1.6|
Bile Duct, Hyperplasia | 1 1 2 1 1 2 1 2 1 2 1 1 2 2 1| 31 1.4|
Centrilobular, Degeneration | 1 | 1 1.0|
Centrilobular, Necrosis | 3 | 5 2.8|
Hepatocyte, Atrophy | 1 2 | 2 1.5|
Oval Cell, Hyperplasia | 3 | 1 3.0|
Sinusoid, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Mineralization | | 1 2.0|
Artery, Inflammation | 4 | 5 3.4|
Artery, Mineralization | 2 | 2 2.0|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 5 |
Inflammation, Suppurative | 2 | 3 1.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Atrophy | 2 | 2 1.5|
Basophilic Focus | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 4 4 3 1 1 2 3 1 3 | 18 2.9|
Necrosis | | 1 1.0|
Acinus, Hyperplasia | 3 | 1 3.0|
Artery, Inflammation | 4 3 | 3 3.3|
Artery, Mineralization | 3 | 2 2.5|
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Artery, Mineralization | 2 | 2 2.5|
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 1 3.0|
Hyperplasia, Squamous | 1 | 2 2.0|
Inflammation, Acute | 1 | 1 1.0|
Mineralization | 4 2 1 | 3 2.3|
Ulcer, Chronic | | 1 4.0|
Ulcer | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 2 | 3 2.0|
Hyperplasia | 1 | 1 1.0|
Mineralization | 3 4 1 4 1 | 8 2.8|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 8 |
Mineralization | 3 2 4 2 | 6 2.8|
Aorta, Mineralization | 4 2 4 2 | 7 3.0|
Pulmonary Artery, Mineralization | 3 | 3 3.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 4 2 3 3 3 3 3 2 3 3 2 2 3 3 3 3 1 1 3 2 2 3| 49 2.5|
Inflammation, Chronic | 4 | 1 4.0|
Mineralization | 1 3 4 | 6 2.0|
Thrombosis | | 1 2.0|
Artery, Mineralization | 3 4 2 | 4 2.8|
Artery, Thrombosis | 2 | 1 2.0|
Atrium, Thrombosis | 3 | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Angiectasis | | 1 2.0|
Hemorrhage | | 3 2.3|
Hyperplasia | | 1 4.0|
Hypertrophy | | 2 1.5|
Vacuolization Cytoplasmic | 1 1 1 3 1 1 1 1 | 17 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 4 3 4 4 4 4 2 2 4 4 2| 16 3.3|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 1 1 4 1 1 1 2 1 1| 17 1.8|
Hyperplasia | 4 2 1 3 2 1 | 13 2.2|
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicle, Cyst | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 2 2 4 4 3 2 2 | 12 2.8|
Duct, Cyst | 2 2 2 2 2 3 4 2 3 3 1 2 4 4 4 3 2 2 4 1 4 4 3 3 2| 49 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Hyperplasia | | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 4 1.3|
Inflammation, Chronic | 1 1 2 | 3 1.3|
Inflammation, Chronic Active | 2 2 | 5 1.6|
Artery, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 1 1 2 4 2 2 2 1 1 3 | 20 2.3|
Mineralization | 1 1 2 | 6 1.2|
Artery, Inflammation | 3 2 4 2 1 2 1 4 2 3 3 2 1 4 2 1 | 24 2.3|
Interstitial Cell, Hyperplasia | 1 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 31 |
Ectasia | | 2 2.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Plasma Cell | 3 | 2 3.0|
Iliac, Ectasia | 4 4 2 | 5 3.2|
Iliac, Hemorrhage | | 1 2.0|
Inguinal, Atrophy | | 1 2.0|
Inguinal, Ectasia | | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Ectasia | 1 3 | 6 1.8|
Mediastinal, Hemorrhage | 1 3 1 3 | 8 2.4|
Pancreatic, Ectasia | 3 | 2 3.5|
Pancreatic, Hemorrhage | 3 2 1 | 4 2.3|
Pancreatic, Hyperplasia, Lymphoid | 2 | 2 2.5|
Pancreatic, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Renal, Ectasia | 4 4 2 4 4 3 2 4| 15 3.3|
Renal, Hemorrhage | 3 3 4 1 2 1| 10 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Ectasia | 2 1 3 3 3 2 | 15 1.9|
Hemorrhage | 2 1 | 3 2.3|
Hyperplasia, Plasma Cell | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Ectasia | 4 2 | 5 2.0|
Hemorrhage | 4 1 1 2 2 1 | 12 2.1|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Atrophy | | 2 2.5|
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 1.0|
Artery, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 4 4 3 4 4 4 4 2 | 15 3.6|
Cyst | 4 1 1 1 | 5 1.8|
Ectopic Parathyroid Gland | 2 | 3 2.0|
Ectopic Thyroid | 2 | 1 2.0|
Hemorrhage | 3 2 2 1 1 2| 8 1.8|
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1| 4 1.3|
Artery, Mineralization | 1 | 3 1.3|
Duct, Dilatation | 2 3 | 6 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 4.0|
Hair Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 4 3 4 2 1 | 10 2.8|
Cranium, Fibrous Osteodystrophy | 2 4 1 4 1 2 | 10 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hydrocephalus | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 2 1.5|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Granulomatous | 1 1 | 4 1.0|
Necrosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 2 | 8 1.9|
Alveolus, Mineralization | 1 | 2 1.0|
Artery, Mineralization | 3 | 2 2.0|
Bronchus, Inflammation, Acute | 4 | 1 4.0|
Bronchus, Mineralization | | 1 1.0|
Interstitium, Fibrosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Erosion | | 1 2.0|
Foreign Body | X X X X X X X | 11 |
Hemorrhage | 1 | 3 2.3|
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Acute | 2 3 2 4 | 7 2.4|
Inflammation, Chronic | | 7 1.6|
Inflammation, Chronic Active | 1 3 3 | 4 2.3|
Olfactory Epithelium, Hyperplasia | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 3 2 1 2 2 2 2 2 | 20 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 4 2.5|
Cyst | 2 2 1 3 2 2 2 2 3 2 3 | 21 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 6| 5| 6| 7| 7| 6| 2| 7| 5| 6| 7| 5| 7| 5| 6| 7| 6| 5| 6| 7| 5| |
DAY ON TEST | 0| 6| 9| 2| 3| 7| 1| 2| 2| 9| 8| 2| 9| 8| 2| 7| 2| 8| 7| 2| 2| 5| 4| 2| 3| |
| 1| 0| 8| 2| 9| 6| 8| 2| 2| 5| 3| 2| 2| 1| 2| 2| 2| 7| 4| 2| 4| 9| 4| 2| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | 1 2 1 2 2 2 2 1 2 1 2 1 1 2 1 3 1| 19 1.6|
Mineralization | 2 1 2 1 1 | 8 1.5|
Nephropathy | 4 2 3 4 4 4 4 3 3 4 1 4 3 4 2 2 4 3 4 2 4 4 4 4 4| 50 3.3|
Artery, Mineralization | 2 2 | 5 2.0|
Renal Tubule, Hyperplasia | 3 2 1 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + A + + +| 47 |
Inflammation, Chronic | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 7| 6| 4| 6| 5| 7| 7| 3| 6| 5| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 3| 9| 2| 3| 8| 5| 7| 2| 2| 7| 3| 9| 6| 1| 2| 2| 9| 1| 1| 2| 2| 2|
| 9| 2| 1| 9| 0| 2| 8| 6| 1| 3| 2| 2| 2| 4| 3| 0| 6| 2| 2| 5| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + + A A + + + + A + + + + A A A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + A + + + A A + + + + A + + + + A + A + + +|
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A A + + + A + + + + + A A + + + A + A + + +|
Edema | |
Hemorrhage | 2 |
Inflammation, Acute | 2 |
Ulcer | 4 |
Artery, Mineralization | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A A + + + A A + A + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A A + + + A A + + + A A + + + + A A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 |
Clear Cell Focus | X X X X X|
Congestion | 2 3 3 2 3 3 2 |
Degeneration, Cystic | 1 1 1 2 1 1 1 |
Eosinophilic Focus | X X X X X X |
Fibrosis | 1 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | 1 |
Mineralization | |
Necrosis | 1 4 1 1 3 1|
Pigmentation | 1 1 3 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 2 3 1 1 2 2 1|
Artery, Mineralization | |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 3 2 1 1 1 1 1 2 1 1 1 2 2|
Centrilobular, Cytomegaly | |
Centrilobular, Degeneration | 3 3 2 1 1 2 1 |
Centrilobular, Hypertrophy | |
Centrilobular, Necrosis | 1 3 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation | 2 |
__________________________________________________________________________|
Oral Mucosa | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 |
Hemorrhage | |
Hyperplasia | 2 2 2 4 4 2 3 3 3|
Artery, Inflammation | 1 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 7| 6| 4| 6| 5| 7| 7| 3| 6| 5| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 3| 9| 2| 3| 8| 5| 7| 2| 2| 7| 3| 9| 6| 1| 2| 2| 9| 1| 1| 2| 2| 2|
| 9| 2| 1| 9| 0| 2| 8| 6| 1| 3| 2| 2| 2| 4| 3| 0| 6| 2| 2| 5| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Artery, Mineralization | 3 3 3 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Artery, Mineralization | 2 2 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 3 2 4 1 2 1 4 |
Mineralization | 4 2 |
Ulcer | 4 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 |
Fibrosis | 1 |
Mineralization | 1 3 4 3 2 1 4 4 4 1 4 3 |
Serosa, Edema | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Granulomatous | |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + |
Mineralization | 4 1 |
Aorta, Mineralization | 1 4 2 1 2 4 4 1 4 4 |
Pulmonary Artery, Degeneration | |
Pulmonary Artery, Mineralization | 1 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 1 4 3 2 3 3 4 2 3 3 1 2 2 3 4 3 2 3 3 3 2 2 1|
Mineralization | 1 2 1 2 1 2 2 |
Artery, Inflammation | 3 |
Artery, Mineralization | 1 1 2 2 4 3 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Degeneration | 2 2 |
Hyperplasia | |
Hypertrophy | 2 1 |
Mineralization | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 2 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 7| 6| 4| 6| 5| 7| 7| 3| 6| 5| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 3| 9| 2| 3| 8| 5| 7| 2| 2| 7| 3| 9| 6| 1| 2| 2| 9| 1| 1| 2| 2| 2|
| 9| 2| 1| 9| 0| 2| 8| 6| 1| 3| 2| 2| 2| 4| 3| 0| 6| 2| 2| 5| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 3 2 2 3 1 4 2 2 2 4 4 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 2 2 1|
Hyperplasia | 2 4 2 3 2 4 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | 1 2 |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + M + + + + + + + M + + + M + M + M + + M +|
Inflammation, Acute | 3 |
Artery, Mineralization | |
__________________________________________________________________________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + M M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 1 2 2 |
Duct, Cyst | 3 1 3 1 1 2 4 3 4 4 2 2 2 2 2 1 3 2 2 3|
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 4 |
Inflammation, Chronic Active | 1 4 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
Artery, Mineralization | |
__________________________________________________________________________|
Testes | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 2 3 2 4 2 1 |
Mineralization | 1 |
Artery, Inflammation | 2 4 3 4 2 3 2 3|
Artery, Mineralization | 2 |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 7| 6| 4| 6| 5| 7| 7| 3| 6| 5| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 3| 9| 2| 3| 8| 5| 7| 2| 2| 7| 3| 9| 6| 1| 2| 2| 9| 1| 1| 2| 2| 2|
| 9| 2| 1| 9| 0| 2| 8| 6| 1| 3| 2| 2| 2| 4| 3| 0| 6| 2| 2| 5| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 |
Iliac, Ectasia | 2 4 |
Iliac, Hemorrhage | 4 |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 4 2 |
Inguinal, Hemorrhage | 1|
Mediastinal, Atrophy | |
Mediastinal, Congestion | 3 4 |
Mediastinal, Ectasia | 1 3 1 1 4 2 2 |
Mediastinal, Hemorrhage | 4 3 2 2 3 2 2 4 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 2 |
Pancreatic, Ectasia | 3 4 |
Pancreatic, Hemorrhage | 2 3 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Renal, Ectasia | 3 4 3 3 3 3 2 |
Renal, Fibrosis | |
Renal, Hemorrhage | 2 3 2 2 3 |
Renal, Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Ectasia | 1 3 2 4 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 4 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Ectasia | 2 1|
Hemorrhage | 3 3 3 1 1 2 2 1|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Artery, Mineralization | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | 2 4 4 4 4 4 3 4 2 4 2 4 4 |
Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 7| 6| 4| 6| 5| 7| 7| 3| 6| 5| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 3| 9| 2| 3| 8| 5| 7| 2| 2| 7| 3| 9| 6| 1| 2| 2| 9| 1| 1| 2| 2| 2|
| 9| 2| 1| 9| 0| 2| 8| 6| 1| 3| 2| 2| 2| 4| 3| 0| 6| 2| 2| 5| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectopic Parathyroid Gland | 2 2 |
Hemorrhage | 2 1 1 |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + M + + + + + + + +|
Cyst | 3 |
Artery, Mineralization | 2 2 |
Duct, Dilatation | 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 3 2 1 1 2 2 4 2 |
Inflammation, Chronic Active | |
Cranium, Fibrous Osteodystrophy | 4 2 2 1 4 3 |
Rib, Callus | 3 |
Vertebra, Fibrous Osteodystrophy | 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Hemorrhage | 2 |
Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | + + |
Mineralization | 1 1 |
Radicular Neuropathy | 2 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 |
Edema | 2 2 |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Granulomatous | 2 |
Mineralization | |
Alveolar Epithelium, Hypertrophy | |
Alveolus, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 6| 7| 6| 4| 6| 5| 7| 7| 3| 6| 5| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 3| 9| 2| 3| 8| 5| 7| 2| 2| 7| 3| 9| 6| 1| 2| 2| 9| 1| 1| 2| 2| 2|
| 9| 2| 1| 9| 0| 2| 8| 6| 1| 3| 2| 2| 2| 4| 3| 0| 6| 2| 2| 5| 4| 1| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | 1 1 |
Artery, Mineralization | |
Interstitium, Fibrosis | 1 1 |
Interstitium, Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Acute | 3 1 3 1 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 3 |
Metaplasia, Squamous | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 1 |
Respiratory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 1 3 3 3 1 4 4 2 2 2 2 4 4 |
Hydronephrosis | 1 2 2 2 2 2 2|
Inflammation, Acute | 3 3 |
Mineralization | 1 2 2 3 1 3 3 3 |
Nephropathy | 4 4 4 4 4 4 4 4 4 4 3 2 3 4 3 4 4 2 4 4 4 4 4 3 3|
Artery, Mineralization | 2 2 |
Renal Tubule, Hyperplasia | 2 4 2 2 4 |
Vein, Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Acute | 1 |
Ulcer | 4 |
Transitional Epithelium, Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + A A + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| 42 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + A + A + + + + + + + + + + A A + + + +| 37 |
Edema | 3 | 1 3.0|
Hemorrhage | 2 | 2 2.0|
Inflammation, Acute | 4 | 2 3.0|
Ulcer | 3 | 2 3.5|
Artery, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + A + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + A + + A + + + + + + + A + + A A + + + +| 36 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + A A + A + + + + + + + + + + A A + A A +| 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 2 | 9 1.8|
Clear Cell Focus | X X | 7 |
Congestion | 2 3 2 2 2 | 12 2.4|
Degeneration, Cystic | 1 3 2 1 2 1 | 13 1.4|
Eosinophilic Focus | X X X X X X | 12 |
Fibrosis | 2 2 1 | 5 1.4|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Mineralization | 1 | 1 1.0|
Necrosis | 1 | 7 1.7|
Pigmentation | 2 1 1 1 2 1 1| 15 1.3|
Vacuolization Cytoplasmic | 1 2 3 4 2 2 3 2 2 | 18 1.9|
Artery, Mineralization | 2 | 1 2.0|
Bile Duct, Dilatation | 2 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 2 1 1 1 1 4 2 1 1 1 2 | 33 1.4|
Centrilobular, Cytomegaly | 1 | 1 1.0|
Centrilobular, Degeneration | 2 1 2 2 2 1 2 2| 15 1.8|
Centrilobular, Hypertrophy | 1 | 1 1.0|
Centrilobular, Necrosis | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 3 1.3|
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 2 4 2 2 4 2 4 2 3 | 18 2.8|
Artery, Inflammation | 4 4 2| 5 2.6|
Artery, Mineralization | 2 2 2 | 6 2.5|
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 1 | 1 1.0|
Artery, Mineralization | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 2 2 4 2| 13 2.4|
Mineralization | 2 3 3 | 5 2.8|
Ulcer | 2| 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 3 1.3|
Fibrosis | | 1 1.0|
Mineralization | 3 3 3 4 3 2 4 4 1 2 1 3 3| 25 2.8|
Serosa, Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + +| 23 |
Mineralization | 2 2 2 4| 6 2.5|
Aorta, Mineralization | 2 4 3 4 4 1 1 4 4 1 4| 21 2.8|
Pulmonary Artery, Degeneration | 2 | 1 2.0|
Pulmonary Artery, Mineralization | 3 | 3 2.7|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 4 2 2 3 3 4 2 3 3 2 3 3 4 2 3 3 3 3 3 3 2 2 3 4| 49 2.7|
Mineralization | 3 1 3 1 1 2 1 3 1 3| 17 1.8|
Artery, Inflammation | | 1 3.0|
Artery, Mineralization | 3 1 3 2 2 3 2 1 3 | 15 2.2|
Atrium, Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.5|
Degeneration | | 2 2.0|
Hyperplasia | 2 3 | 2 2.5|
Hypertrophy | | 2 1.5|
Mineralization | | 1 2.0|
Thrombosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 1 1 2 1 3 2 1 2 | 13 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 3 | 4 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Hyperplasia | 4 4 4 4 4 4 1 4 2 3 4 4 4 4 3 4 4| 32 3.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 1 2 3 1 2 | 13 1.8|
Hyperplasia | 2 4 4 3 | 10 3.0|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 | 1 3.0|
Follicle, Cyst | 1 1| 4 1.3|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + M M +| 42 |
Inflammation, Acute | | 1 3.0|
Artery, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 2 | 2 2.0|
Inflammation, Suppurative | 3 1 1 2| 9 1.8|
Duct, Cyst | 1 1 3 2 1 3 2 2 2 2 2 2 3 3 3 2 2 2 2 3 4 3 3| 43 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 4 2 | 4 2.3|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 1 | 4 2.0|
Inflammation, Chronic Active | 4 4 | 5 3.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Artery, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 1 3 4 3 3 2 1 3 3| 20 2.3|
Mineralization | 1 | 2 1.0|
Artery, Inflammation | 3 3 1 2 1 3 1 4 2 2 1 4 3 3 3 3| 24 2.6|
Artery, Mineralization | 1 2| 3 1.7|
Interstitial Cell, Hyperplasia | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Erythroid Cell, Hyperplasia | | 1 3.0|
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + | 44 |
Ectasia | | 1 2.0|
Hemorrhage | | 1 2.0|
Iliac, Ectasia | 2 | 3 2.7|
Iliac, Hemorrhage | 2 | 2 3.0|
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | 2 3 | 4 2.8|
Inguinal, Hemorrhage | | 1 1.0|
Mediastinal, Atrophy | 3 | 1 3.0|
Mediastinal, Congestion | 4 | 3 3.7|
Mediastinal, Ectasia | 2 1 3 2 2 | 12 2.0|
Mediastinal, Hemorrhage | 1 3 2 3 2 1 | 15 2.4|
Mediastinal, Hyperplasia, Plasma Cell| | 2 2.0|
Pancreatic, Ectasia | 2 4 4 | 5 3.4|
Pancreatic, Hemorrhage | 2 2 2 | 5 2.2|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Ectasia | 4 4 3 4 4 4 3 3 3 3 3 3 4 | 20 3.3|
Renal, Fibrosis | 2 2 | 2 2.0|
Renal, Hemorrhage | 2 2 3 2 4 3 3 2 2 3 3 3 | 17 2.6|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 3 | 5 2.6|
Ectasia | 2 2 | 8 2.3|
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | 2 2 2 4 | 8 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 4| 6 2.5|
Ectasia | 2 2 2 3 | 6 2.0|
Hemorrhage | 2 1 3 1 2 2| 14 1.9|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 2 | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Artery, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 3 4 3 3 4 1 4 4 2 3 4 4 1 1 4| 29 3.2|
Cyst | 2 2 1 1 | 6 1.7|
Ectopic Parathyroid Gland | 2 2 2 | 5 2.0|
Hemorrhage | 1 2 2 | 6 1.5|
Artery, Mineralization | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + M + + + + + + +| 46 |
Cyst | 3| 2 3.0|
Artery, Mineralization | 2 2 2 | 5 2.0|
Duct, Dilatation | 2 1 2 1 | 7 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2| 2 2.0|
Hyperplasia, Squamous | 3 | 2 2.5|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 3 4 3 3 2 4 4 3 4 3| 21 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 4 | 1 4.0|
Cranium, Fibrous Osteodystrophy | 1 3 2 1 1 4 4 2 1 | 15 2.3|
Rib, Callus | | 1 3.0|
Vertebra, Fibrous Osteodystrophy | 1 1| 4 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Degeneration | | 1 1.0|
Hemorrhage | | 1 2.0|
Hydrocephalus | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + +| 4 |
Mineralization | | 2 1.0|
Radicular Neuropathy | 1 1| 4 1.3|
__________________________________________________________________________|____________|
Spinal Cord | + +| 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 4 2.8|
Edema | | 2 2.0|
Hemorrhage | 1 | 1 1.0|
Inflammation, Acute | 3 1 2 | 3 2.0|
Inflammation, Granulomatous | | 1 2.0|
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hypertrophy | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 3 | 5 1.8|
Artery, Mineralization | 3 1 1 | 3 1.7|
Interstitium, Fibrosis | 1 3 2 2 | 6 1.7|
Interstitium, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X | 4 |
Inflammation, Acute | 1 4 | 7 2.1|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 3 1 3 1 | 6 2.3|
Metaplasia, Squamous | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 3 1 1 2 2 2 | 9 1.8|
Respiratory Epithelium, Metaplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 4| 5| 5| 3| 4| 3| 7| 6| 6| 7| 6| 5| 7| 7| 6| 5| 6| 7| 6| 4| 7| 5| 6| 5| |
DAY ON TEST | 2| 4| 3| 8| 3| 7| 5| 1| 8| 1| 2| 9| 6| 2| 2| 6| 4| 7| 2| 9| 7| 2| 5| 4| 0| |
| 2| 5| 6| 1| 6| 9| 2| 0| 2| 0| 2| 8| 1| 2| 2| 8| 9| 9| 2| 7| 0| 2| 2| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 2 2 3 2 3 2 3 2 2 3 3 2 3 1 2| 31 2.5|
Hydronephrosis | 1 3 2 2 1 1 2 2 1 2 2 1 2 | 20 1.8|
Inflammation, Acute | | 2 3.0|
Mineralization | 1 2 3 2 2 1 2 2 2| 17 2.1|
Nephropathy | 3 4 4 4 2 4 4 2 4 4 4 3 4 4 3 4 4 4 4 4 1 4 1 4 4| 50 3.6|
Artery, Mineralization | 3 1 2 3 1 1| 8 1.9|
Renal Tubule, Hyperplasia | 2 2 1 2 1 2 1 3 2 1 1 3| 17 2.1|
Vein, Thrombosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 1 2.0|
Inflammation, Acute | | 1 1.0|
Ulcer | | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Intestine Large, Colon | A + A + + A A + + + A + + + A + + A + + + + A A +|
Mineralization | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | A + A + + A A + + + A + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + A + + A A + + + A + + + A + + A + A + + A A +|
Congestion | |
Hemorrhage | |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + A A + + + A A + + A + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + + A A + + + A A + + A + + A + A + + A A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Clear Cell Focus | X X X X X |
Congestion | 3 4 2 3 |
Degeneration, Cystic | 2 1 2 1 |
Eosinophilic Focus | X X |
Fibrosis | 1 2 1 1 1 1 1 2 1 1 2 2 2 3 2 1|
Hemorrhage | 2 1 |
Hepatodiaphragmatic Nodule | X |
Hypertrophy | 2 |
Infarct | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 2 2 2 |
Mineralization | |
Mixed Cell Focus | X |
Necrosis | |
Pigmentation | 1 2 3 1 2 1 2 1 3 2 3 3 2 1 1 1 2 2|
Tension Lipidosis | X |
Thrombosis | |
Vacuolization Cytoplasmic | 1 2 2 2 1 2 1 4 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 3 2 1 3 1 1 1 1 2 3 1 4 1 3 1 1 1|
Centrilobular, Cytomegaly | 3 |
Centrilobular, Degeneration | 1 3 1 2 4 1 3 1 3 3 3 1 1|
Centrilobular, Necrosis | 2 2 |
Hepatocyte, Atrophy | 2 |
Periportal, Fibrosis | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Vein, Thrombosis | 4 2 |
__________________________________________________________________________|
Oral Mucosa | + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Edema | |
Fibrosis | 2 |
Hyperplasia | 4 2 4 3 3 |
Acinus, Hyperplasia | 3 |
Artery, Inflammation | |
Artery, Mineralization | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Foreign Body | |
Hemorrhage | |
Hyperplasia, Squamous | 4 3 2 1 1 3 4|
Inflammation, Chronic | |
Mineralization | |
Ulcer | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + A + +|
Erosion | |
Hemorrhage | |
Hyperplasia | |
Inflammation, Chronic Active | 2 |
Mineralization | 4 2 4 3 1 3 1 |
Ulcer | 4 |
Artery, Mineralization | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + +|
Peridontal Tissue, Inflammation, | |
Suppurative | 4 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + |
Mineralization | |
Aorta, Mineralization | 3 4 2 1 3 2 |
Pulmonary Artery, Mineralization | 3 3 1 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 4 3 4 4 3 2 2 3 4 2 2 3 1 2 3 2 1 3 2 3 3 2|
Mineralization | 3 1 1 3 2 |
Thrombosis | |
Artery, Mineralization | 3 3 2 2 |
Atrium, Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia | |
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 2 2 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 4 2 4 1 4 4 4 4 2 4 2 1|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 2 2 1 2 3 2 1 3 |
Hemorrhage | |
Hyperplasia | 4 4 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 3 4 2 |
Follicular Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | M + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Chronic | 2 3 1 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 3 4 4 |
Duct, Cyst | 1 3 2 2 3 2 2 2 1 2 1 2 2 2 2 2 2 1 2 3 3 3 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 |
Hemorrhage | |
Hyperplasia | |
Inflammation, Chronic | 2 2 1 4|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 4 2 1 3 1 2 2 4 1 |
Inflammation, Granulomatous | |
Mineralization | 1 1 1 1 1 |
Artery, Inflammation | 2 2 2 1 1 2 3 |
Artery, Mineralization | 1 3 |
Interstitial Cell, Hyperplasia | 2 4 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Iliac, Ectasia | 2 4|
Iliac, Hemorrhage | 3 |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Plasma Cell | 3|
Inguinal, Ectasia | 2 |
Inguinal, Hemorrhage | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Inguinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Congestion | 3 |
Mediastinal, Ectasia | 1 2 2 2 2 2 1 1 1|
Mediastinal, Hemorrhage | 2 3 2 1 3 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Pancreatic, Hemorrhage | 2 2 1|
Pancreatic, Hyperplasia, Plasma Cell | 2 |
Pancreatic, Pigmentation | 2 |
Renal, Ectasia | 4 2 3 3 2 2 3 2 4 1|
Renal, Hemorrhage | 2 2 3 3 1 2 1 2 3 2 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 2 2 2|
Renal, Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 4 4 1 2 2 |
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | 3 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 1 1 2 2 2 |
Hemorrhage | 3 3 3 2 2 1 1 1 |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Atrophy | 2 |
Congestion | |
Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 4 2 4 3 2 4 3 4 4 1 2 2 |
Cyst | 2 |
Ectopic Parathyroid Gland | 2 |
Fibrosis | 4 |
Hemorrhage | 2 2 3 |
Epithelial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + M M + + + + + + + M + M + + + + +|
Hyperplasia | 2 |
Duct, Dilatation | 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 3 4 3 3 4 1 |
Osteosclerosis | |
Cranium, Fibrous Osteodystrophy | 3 2 3 2 3 2 3 |
Joint, Inflammation, Chronic | 3 |
Metatarsal, Hyperplasia | |
Vertebra, Fibrous Osteodystrophy | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + |
Mineralization | 1 1 |
Radicular Neuropathy | 2 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 1 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 2 1 1|
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2|
Interstitium, Fibrosis | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 2 3 |
Metaplasia, Squamous | 2 |
Thrombosis | |
Ulcer | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 1 1 2 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cornea, Ulcer | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | |
Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 4 2 1 2 1 2 3 3 4 2 |
Hydronephrosis | 3 2 1 3 2 2 2 3 1 1 1 1 2 2 2 |
Mineralization | 2 1 1 2 |
Nephropathy | 3 3 3 4 4 4 4 4 2 3 3 4 4 3 4 3 3 4 4 4 4 3 4 4 3|
Artery, Mineralization | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Hyperplasia | 3 3 2 2 2 3 |
Vein, Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + A + +|
Dilatation | |
Hemorrhage | |
Inflammation, Chronic Active | 1|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 6| 4| 5| 6| 7| 7| 6| 3| 4| 6| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7|
DAY ON TEST | 5| 2| 8| 2| 2| 3| 8| 2| 8| 2| 0| 2| 5| 0| 0| 2| 2| 7| 0| 8| 2| 0| 2| 4| 2|
| 0| 2| 7| 2| 2| 2| 6| 0| 3| 2| 0| 8| 4| 4| 8| 2| 2| 4| 1| 2| 1| 4| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Mineralization | |
Transitional Epithelium, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + A + + + A + A + + A + + + +| 36 |
Mineralization | | 1 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + A + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + M + A A A + + A A A + + A + A + A| 29 |
Congestion | 3 | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Inflammation, Acute | 2 | 2 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A A A + + + + A + + A + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + A A A + + + A A + + A + A + +| 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + A + + A A + + + + A A + A A + A + A| 28 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 3.0|
Clear Cell Focus | X X X | 8 |
Congestion | 3 3 | 6 3.0|
Degeneration, Cystic | 1 1 1 1 1 | 9 1.2|
Eosinophilic Focus | X X | 4 |
Fibrosis | 1 1 1 3 1 3 2 2 1 2 | 26 1.6|
Hemorrhage | 3 2 2 | 5 2.0|
Hepatodiaphragmatic Nodule | X | 2 |
Hypertrophy | | 1 2.0|
Infarct | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 3 | 2 2.5|
Inflammation, Acute | | 3 2.0|
Mineralization | 2 1 1| 3 1.3|
Mixed Cell Focus | | 1 |
Necrosis | 1 2 1 2 2 2 | 6 1.7|
Pigmentation | 2 2 1 1 2 3 2 1 2 2 3 1 1 1 2 3 | 34 1.8|
Tension Lipidosis | | 1 |
Thrombosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 3 1 2 | 12 1.8|
Bile Duct, Cyst | 4 3| 2 3.5|
Bile Duct, Hyperplasia | 1 1 1 1 3 2 1 1 4 3 2 2 1 | 30 1.8|
Centrilobular, Cytomegaly | | 1 3.0|
Centrilobular, Degeneration | 2 1 4 3 3 2 2 1 2 1 1 3 | 25 2.1|
Centrilobular, Necrosis | 3 4| 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocyte, Atrophy | | 1 2.0|
Periportal, Fibrosis | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Vein, Thrombosis | | 2 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 3 2.0|
Edema | 2 | 1 2.0|
Fibrosis | | 1 2.0|
Hyperplasia | 3 4 2| 8 3.1|
Acinus, Hyperplasia | | 1 3.0|
Artery, Inflammation | 3 3 3 | 3 3.0|
Artery, Mineralization | 4 | 1 4.0|
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + + + + M M + + + + + + + + + + + +| 47 |
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Foreign Body | X | 1 |
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Squamous | 2 2 1 2 | 11 2.3|
Inflammation, Chronic | 1 | 1 1.0|
Mineralization | 4 4 4 | 3 4.0|
Ulcer | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 1 4 | 2 2.5|
Hemorrhage | 1 4| 2 2.5|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 4 3 2 2 2 1 4 2 2 | 16 2.5|
Ulcer | | 1 4.0|
Artery, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + | 4 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 12 |
Mineralization | 4 | 1 4.0|
Aorta, Mineralization | 4 4 4 3 | 10 3.0|
Pulmonary Artery, Mineralization | 2 | 5 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 3 2 3 3 3 3 2 3 4 3 3 3 3 3 4 3 3 3 3 4 3 2| 49 2.7|
Mineralization | 1 3 2 1 2 2 3 | 12 2.0|
Thrombosis | 1 | 1 1.0|
Artery, Mineralization | 3 3 3 2 2 | 9 2.6|
Atrium, Dilatation | | 1 4.0|
Atrium, Thrombosis | 4 | 5 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Hyperplasia | 3 | 1 3.0|
Hypertrophy | 2 | 2 2.0|
Vacuolization Cytoplasmic | 1 1 3 1 2 1| 12 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| 48 |
Hyperplasia | 4 4 4 4 2 2 4 4 3 3 2 4 2 2| 29 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 2 2 1 1 1 2 | 18 1.9|
Hemorrhage | 1 | 1 1.0|
Hyperplasia | 3 3 4 | 7 3.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| 48 |
Inflammation, Granulomatous | | 1 2.0|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | 3 | 5 2.8|
Follicular Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + M + + + + + + M + + + + + M + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Inflammation, Chronic | | 3 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Suppurative | 2 3 3 3 2 2 | 10 2.8|
Duct, Cyst | 2 4 3 4 3 2 3 2 2 3 4 2 2 3 2 2 2 3 3 3 2 3 2| 46 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 1.5|
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 1 | 5 2.0|
Inflammation, Chronic Active | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Atrophy | 3 3 3 2 3 4 4 | 18 2.7|
Inflammation, Granulomatous | 3 | 1 3.0|
Mineralization | 2 1 1 2 | 9 1.2|
Artery, Inflammation | 3 2 2 3 2 3 2| 14 2.1|
Artery, Mineralization | | 2 2.0|
Interstitial Cell, Hyperplasia | 2 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 38 |
Iliac, Ectasia | 3 | 3 3.0|
Iliac, Hemorrhage | 2 | 2 2.5|
Iliac, Hyperplasia, Lymphoid | 2 | 2 2.0|
Iliac, Hyperplasia, Plasma Cell | 3 | 2 3.0|
Inguinal, Ectasia | | 1 2.0|
Inguinal, Hemorrhage | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Mediastinal, Congestion | 3 | 2 3.0|
Mediastinal, Ectasia | | 9 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 3 2 1 3 2 | 10 2.2|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Pancreatic, Hemorrhage | 2 | 4 1.8|
Pancreatic, Hyperplasia, Plasma Cell | 2 | 2 2.0|
Pancreatic, Pigmentation | | 1 2.0|
Renal, Ectasia | 2 3 2 2 2 4 | 16 2.6|
Renal, Hemorrhage | 1 1 2 2 2 2 4 3| 19 2.2|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hyperplasia, Plasma Cell | 3 3 | 6 2.5|
Renal, Pigmentation | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + M M + + + + + + + + + + + +| 47 |
Congestion | 3 | 1 3.0|
Ectasia | 2 2 2 2 3| 10 2.4|
Hemorrhage | 2 2 | 3 1.7|
Hyperplasia, Plasma Cell | 4 4| 6 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Ectasia | 1 | 6 1.5|
Hemorrhage | 1 2 1 2 | 12 1.8|
Hyperplasia, Lymphoid | 3 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Congestion | 2 | 1 2.0|
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 4 4 4 3 3 4 3 4 3 1 3 4 3 | 28 3.1|
Cyst | 2 2 1 | 4 1.8|
Ectopic Parathyroid Gland | | 1 2.0|
Fibrosis | | 1 4.0|
Hemorrhage | 2 2 1 1 1| 8 1.8|
Epithelial Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 44 |
Hyperplasia | 3 | 2 2.5|
Duct, Dilatation | 2 2 | 5 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 3 3 3 3 4 2 | 16 2.9|
Osteosclerosis | 2 | 1 2.0|
Cranium, Fibrous Osteodystrophy | 4 1 3 3 4 4 | 13 2.8|
Joint, Inflammation, Chronic | | 1 3.0|
Metatarsal, Hyperplasia | 4 | 1 4.0|
Vertebra, Fibrous Osteodystrophy | | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | +| 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
Mineralization | | 2 1.0|
Radicular Neuropathy | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.5|
Hemorrhage | 2 1 1 1 1 1 2 1 1| 10 1.2|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Granulomatous | 1 | 5 1.2|
Necrosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 4 2.3|
Interstitium, Fibrosis | 2 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X X X | 6 |
Hemorrhage | | 1 1.0|
Inflammation, Acute | 3 4 1| 4 2.3|
Inflammation, Chronic | 1 | 2 2.0|
Inflammation, Chronic Active | 4 1 | 5 2.6|
Metaplasia, Squamous | | 1 2.0|
Thrombosis | 3 | 1 3.0|
Ulcer | 2 1 | 2 1.5|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 5| 5| 4| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 4| 6| 6| 4| 6| 4| 6| |
DAY ON TEST | 2| 1| 1| 4| 0| 1| 9| 7| 2| 0| 0| 6| 8| 2| 2| 6| 8| 7| 8| 3| 3| 7| 6| 7| 4| |
| 2| 5| 3| 7| 0| 0| 4| 5| 2| 4| 5| 1| 8| 2| 2| 0| 8| 5| 1| 0| 1| 9| 4| 3| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | 2 2 1 3 1 | 12 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + +| 4 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 3 2 2 4 | 19 2.5|
Hydronephrosis | 1 1 2 2 1 1 3 2 1 2 2 2 2 1 1| 30 1.7|
Mineralization | 3 2 2 2 | 8 1.9|
Nephropathy | 4 3 1 2 4 4 4 4 2 3 4 4 2 3 4 4 4 4 2 4 2 2 4 4 4| 50 3.4|
Artery, Mineralization | 3 2 | 3 2.7|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 2 2 | 8 2.4|
Vein, Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Dilatation | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Artery, Mineralization | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 5| 4| 6| 7| 4| 6| 6| 4| 5| 4| 7| 6| 5| 5| 4| 5| 7| 6| 6|
DAY ON TEST | 0| 8| 2| 3| 2| 2| 9| 4| 0| 2| 5| 7| 8| 9| 5| 8| 2| 8| 3| 3| 6| 6| 2| 8| 3|
| 9| 7| 2| 9| 2| 2| 5| 3| 6| 2| 0| 4| 2| 9| 0| 6| 2| 5| 2| 1| 7| 8| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Acute | |
Ulcer | |
Muscularis, Degeneration | |
__________________________________________________________________________|
Intestine Large, Colon | A A + + + + + A + + A A A + + A + A + A + A + A +|
Mineralization | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | A A + + + + + A + + A A A + + + + A + A + + + + +|
Parasite Metazoan | X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | A A + A + + + A A + A A A + + A + A + A + A + A +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + A + + A A + + + + + A + A + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + A + + A A A + + + + A + A + A + A +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + A A + A A A + + + + A + A + A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Cholangiofibrosis | |
Clear Cell Focus | X X X X X X X|
Congestion | 3 4 2 2 4 3 3 2|
Degeneration, Cystic | 1 1 1 1 1|
Eosinophilic Focus | X |
Fibrosis | 3 2 1 3 1 1 1 3 2 3 1 1 2 1 3 |
Hemorrhage | |
Inflammation, Acute | 1 |
Mineralization | 4 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Pigmentation | 2 2 1 2 1 1 2 2 1 1 2 2 2 1 1 3 1 4 1 1 1|
Regeneration | 2 |
Vacuolization Cytoplasmic | 3 1 3 2 1 1 |
Bile Duct, Cyst | 4 3 |
Bile Duct, Hyperplasia | 1 1 4 2 1 1 1 3 3 1 1 1 1 |
Centrilobular, Cytomegaly | |
Centrilobular, Degeneration | 3 2 3 2 3 1 2 3 2 4 2 1 1 1 3 |
Centrilobular, Necrosis | 2 1 3 4 1 2 3 2 3 2 |
Hepatocyte, Atrophy | |
Periportal, Fibrosis | 3 3 2 3 |
__________________________________________________________________________|
Mesentery | +|
Artery, Inflammation | |
Fat, Necrosis | 2|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 5| 4| 6| 7| 4| 6| 6| 4| 5| 4| 7| 6| 5| 5| 4| 5| 7| 6| 6|
DAY ON TEST | 0| 8| 2| 3| 2| 2| 9| 4| 0| 2| 5| 7| 8| 9| 5| 8| 2| 8| 3| 3| 6| 6| 2| 8| 3|
| 9| 7| 2| 9| 2| 2| 5| 3| 6| 2| 0| 4| 2| 9| 0| 6| 2| 5| 2| 1| 7| 8| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Atrophy | 1 |
Hyperplasia | 4 4 2 2 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Fibrosis | |
Foreign Body | |
Hyperplasia, Squamous | 3 4 3 3|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Erosion | 3 3 2 |
Mineralization | 3 3 3 3 2 |
Artery, Mineralization | |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Chronic | 3 |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Aorta, Mineralization | 2 4 4 |
Pulmonary Artery, Mineralization | 2 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 1 3 2 3 4 3 2 2 3 3 2 3 3 2 3 1 3 2 3 3 4 3|
Mineralization | 3 3 |
Artery, Inflammation, Acute | 2 |
Artery, Mineralization | 1 |
Atrium, Dilatation | |
Atrium, Thrombosis | 3 |
Valve, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hyperplasia | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 5| 4| 6| 7| 4| 6| 6| 4| 5| 4| 7| 6| 5| 5| 4| 5| 7| 6| 6|
DAY ON TEST | 0| 8| 2| 3| 2| 2| 9| 4| 0| 2| 5| 7| 8| 9| 5| 8| 2| 8| 3| 3| 6| 6| 2| 8| 3|
| 9| 7| 2| 9| 2| 2| 5| 3| 6| 2| 0| 4| 2| 9| 0| 6| 2| 5| 2| 1| 7| 8| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 3 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Congestion | 2 2 |
Cyst | 2 2 2 2 |
Hemorrhage | 1 |
Hyperplasia | 3 2 |
Hypertrophy | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | M + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Duct, Cyst | 4 3 3 3 2 1 1 4 1 4 4 2 1 4 2 1 2 2 2 1 3 1 2 4 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
Hyperplasia | 1 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 4 1 3 2 |
Congestion | 2 |
Inflammation, Granulomatous | |
Mineralization | 1 1 |
Artery, Inflammation | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 5| 4| 6| 7| 4| 6| 6| 4| 5| 4| 7| 6| 5| 5| 4| 5| 7| 6| 6|
DAY ON TEST | 0| 8| 2| 3| 2| 2| 9| 4| 0| 2| 5| 7| 8| 9| 5| 8| 2| 8| 3| 3| 6| 6| 2| 8| 3|
| 9| 7| 2| 9| 2| 2| 5| 3| 6| 2| 0| 4| 2| 9| 0| 6| 2| 5| 2| 1| 7| 8| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 1 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Iliac, Ectasia | 2 |
Iliac, Hemorrhage | 2 3 |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Plasma Cell | 2 |
Inguinal, Hemorrhage | 4 |
Mediastinal, Congestion | 3 |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | 1 3 3 2 4 1 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 2 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Plasma Cell | 3 3 |
Renal, Ectasia | 2 2 3 |
Renal, Hemorrhage | 2 2 2 2 3 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Congestion | 3 2 2 |
Ectasia | 3 4 1 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | |
Hemorrhage | 2 2 1 1 1 1 2|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Atrophy | |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 4 4 4 1 4 4 4 4 3 4 3 2|
Cyst | 2 |
Ectopic Parathyroid Gland | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 5| 4| 6| 7| 4| 6| 6| 4| 5| 4| 7| 6| 5| 5| 4| 5| 7| 6| 6|
DAY ON TEST | 0| 8| 2| 3| 2| 2| 9| 4| 0| 2| 5| 7| 8| 9| 5| 8| 2| 8| 3| 3| 6| 6| 2| 8| 3|
| 9| 7| 2| 9| 2| 2| 5| 3| 6| 2| 0| 4| 2| 9| 0| 6| 2| 5| 2| 1| 7| 8| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 3 |
Hyperplasia, Squamous | 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + M + + + + + + + + + M + + + +|
Cyst | |
Hyperplasia | |
Duct, Dilatation | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 |
Ulcer | 3|
Hair Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 2 1 3 |
Cartilage, Degeneration | |
Cranium, Fibrous Osteodystrophy | 2 2 |
Joint, Arthrosis | 4 |
Joint, Fibrosis | 3 |
Joint, Inflammation, Chronic | 4 |
Mandible, Hyperplasia | 3 |
Metacarpal, Inflammation, Chronic | |
Active | |
Metatarsal, Inflammation, Chronic | |
Active | |
Periosteum, Hyperplasia | 4 |
Vertebra, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + +|
Radicular Neuropathy | 2|
__________________________________________________________________________|
Spinal Cord | + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Hemorrhage | 2 4 2 1 |
Inflammation, Granulomatous | 2 1|
Interstitium, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 5| 4| 6| 7| 4| 6| 6| 4| 5| 4| 7| 6| 5| 5| 4| 5| 7| 6| 6|
DAY ON TEST | 0| 8| 2| 3| 2| 2| 9| 4| 0| 2| 5| 7| 8| 9| 5| 8| 2| 8| 3| 3| 6| 6| 2| 8| 3|
| 9| 7| 2| 9| 2| 2| 5| 3| 6| 2| 0| 4| 2| 9| 0| 6| 2| 5| 2| 1| 7| 8| 2| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | X |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 4 3 4 |
Metaplasia, Squamous | 2 |
Artery, Thrombosis | 3 |
Respiratory Epithelium, Hyperplasia | 2 3 2 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Cyst | 1 1 2 2 2 4 2 2 1 2|
Hydronephrosis | 2 2 1 2 2 1 |
Inflammation, Acute | |
Mineralization | 1 1 |
Nephropathy | 2 3 4 2 3 3 4 4 4 3 4 3 3 4 4 4 3 3 2 4 2 4 2 4 3|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
Renal Tubule, Hyperplasia | 3 4 |
Vein, Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + A + A + A +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Acute | 4 | 1 4.0|
Ulcer | 2 | 1 2.0|
Muscularis, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + A A + A + + + + + + + + A + + + + + A +| 33 |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + A +| 40 |
Parasite Metazoan | | 1 |
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + + + A A + A A + + + + A + + A + A + + + A +| 27 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + A A + + A + + + + + + + A + + + + + + +| 35 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A A + A + + + A + + + + + + + A + A + + + A +| 31 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 2 |
Cholangiofibrosis | 2 | 1 2.0|
Clear Cell Focus | X | 8 |
Congestion | 3 3 4 2 2 3 3 3 3 | 17 2.9|
Degeneration, Cystic | | 5 1.0|
Eosinophilic Focus | X | 2 |
Fibrosis | 2 1 2 2 3 3 1 2 1 2 1 1 1 2 2 1| 31 1.8|
Hemorrhage | 1 2 3 | 3 2.0|
Inflammation, Acute | | 1 1.0|
Mineralization | 1 | 3 2.3|
Mixed Cell Focus | | 1 |
Necrosis | 1 | 2 1.5|
Pigmentation | 3 1 3 2 1 3 2 2 2 2 3 1 1 1 2 3 1 3 1 1 3| 42 1.8|
Regeneration | 2 | 2 2.0|
Vacuolization Cytoplasmic | 3 2 1 2 1 2 2 2 2 | 15 1.9|
Bile Duct, Cyst | 2 | 3 3.0|
Bile Duct, Hyperplasia | 3 2 3 2 2 3 3 3 1 2 2 1 1 2| 27 1.9|
Centrilobular, Cytomegaly | 3 | 1 3.0|
Centrilobular, Degeneration | 3 4 3 3 1 1 3 2 2 2 3 4 2 3 3 1 4 2| 33 2.4|
Centrilobular, Necrosis | 2 1 4 3 3 2 3 2 2 3 3 3 3| 23 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocyte, Atrophy | 2 | 1 2.0|
Periportal, Fibrosis | 2 2 2| 7 2.4|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Artery, Inflammation | 4 | 1 4.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 1.0|
Hyperplasia | 3 3 4 | 8 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 2 2.0|
Fibrosis | 2 | 1 2.0|
Foreign Body | X X | 2 |
Hyperplasia, Squamous | 4 1 4 1 3 4 | 10 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 1 | 1 1.0|
Ulcer | 1 4 2 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 3 | 4 2.8|
Mineralization | 2 | 6 2.7|
Artery, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
Aorta, Mineralization | | 3 3.3|
Pulmonary Artery, Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 4 2 3 2 3 2 1 2 2 2 3 3 2 3 2 3 3 3 3 1 4| 47 2.6|
Mineralization | 2 | 3 2.7|
Artery, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Mineralization | 3 | 2 2.0|
Atrium, Dilatation | 3 | 1 3.0|
Atrium, Thrombosis | 4 3 | 3 3.3|
Valve, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Hyperplasia | 3 | 1 3.0|
Necrosis | 2 | 2 2.0|
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 1 3 | 7 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 2 2 1 1 2 2 | 12 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Congestion | | 2 2.0|
Cyst | 3 2 1 1 2 2 2| 11 1.9|
Hemorrhage | | 1 1.0|
Hyperplasia | 4 | 3 3.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicle, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + A + M + + + + + + + + + + + + + + + + M + + + +| 45 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 4 2 | 3 2.7|
Duct, Cyst | 2 3 4 2 4 2 1 1 2 1 3 2 1 1 2 3 4 2 2 3 4 1 2| 48 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hyperplasia | 1 | 2 1.0|
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Chronic Active | 4 1 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 2 | 9 2.3|
Congestion | | 1 2.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Mineralization | 2 1| 4 1.3|
Artery, Inflammation | 1 3 2 1 1 1 1 | 11 1.8|
Interstitial Cell, Hyperplasia | 2 3 4 4 | 7 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 32 |
Iliac, Ectasia | | 1 2.0|
Iliac, Hemorrhage | 2 | 3 2.3|
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | 2 | 2 2.0|
Inguinal, Hemorrhage | | 1 4.0|
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Ectasia | 2 1 1 2 2 | 6 1.7|
Mediastinal, Hemorrhage | 3 1 2 | 9 2.2|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
Pancreatic, Ectasia | 1 | 1 1.0|
Pancreatic, Hemorrhage | 2 2 3 2 | 7 2.1|
Pancreatic, Hyperplasia, Lymphoid | 2 3 3 | 4 2.8|
Pancreatic, Hyperplasia, Plasma Cell | | 2 3.0|
Renal, Ectasia | 4 3 2 4 3 3 1 | 10 2.7|
Renal, Hemorrhage | 2 2 3 2 3 2| 12 2.3|
Renal, Hyperplasia, Lymphoid | 2 2| 2 2.0|
Renal, Hyperplasia, Plasma Cell | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Congestion | 3 | 4 2.5|
Ectasia | 2 3 4 2 1 2 | 10 2.4|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 4 3 | 4 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.5|
Ectasia | 1 1 2 1 1 | 5 1.2|
Hemorrhage | 2 1 1 2 1 | 12 1.4|
Hyperplasia, Lymphoid | 4 2 2 2 | 5 2.4|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 | 1 4.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 3 1 2 3 4 3 2 2 | 24 3.1|
Cyst | 1 1 1 1 2 | 6 1.3|
Ectopic Parathyroid Gland | | 1 2.0|
Hemorrhage | 1 3 1 1 1 3 2 2 3 3 3 2| 14 2.1|
Hyperplasia, Squamous | | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 |
Cyst | 1 | 1 1.0|
Hyperplasia | 3 2 1 1 | 4 1.8|
Duct, Dilatation | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 2 2.5|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Ulcer | 4 | 2 3.5|
Hair Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1| 6 1.7|
Cartilage, Degeneration | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Cranium, Fibrous Osteodystrophy | | 2 2.0|
Joint, Arthrosis | | 1 4.0|
Joint, Fibrosis | | 1 3.0|
Joint, Inflammation, Chronic | | 1 4.0|
Mandible, Hyperplasia | | 1 3.0|
Metacarpal, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
Metatarsal, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
Periosteum, Hyperplasia | | 1 4.0|
Vertebra, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
Radicular Neuropathy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 4 2.3|
Hemorrhage | 1 2 1 | 7 1.9|
Inflammation, Granulomatous | | 2 1.5|
Interstitium, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Acute | 2 | 2 1.5|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 1 2 | 6 2.5|
Metaplasia, Squamous | 2 | 2 2.0|
Artery, Thrombosis | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 2 3 2 1 3 1 3 1 1 1 | 15 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 55301-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 10/08/97
Route: DOSED WATER Time: 12:22:11
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 4| 0| 5| 5| 4| 5| 6| 4| 6| 5| 4| 6| 6| 4| 5| 5| 5| 6| 5| 7| 4| 5| |
DAY ON TEST | 1| 1| 8| 6| 9| 4| 5| 6| 5| 2| 9| 8| 5| 6| 5| 6| 8| 8| 8| 5| 2| 6| 2| 6| 7| |
| 1| 6| 9| 8| 4| 5| 2| 6| 6| 9| 3| 3| 3| 3| 8| 0| 3| 0| 2| 3| 7| 2| 2| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
WISTAR OUTBRED RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
400 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.5|
Cyst | 4 2 2 2 2 2 | 16 2.1|
Hydronephrosis | 2 1 4 1 1 1 1 2 2| 15 1.7|
Inflammation, Acute | 1 | 1 1.0|
Mineralization | 3 1 1 | 5 1.4|
Nephropathy | 4 4 4 2 1 3 3 2 3 4 2 3 3 4 4 4 4 4 2 4 4 3 2 4 4| 50 3.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 2.0|
Renal Tubule, Hyperplasia | 4 1 1 | 5 2.6|
Vein, Thrombosis | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + A + + + + +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
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---------- END OF REPORT ----------
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