TDMS Study 55301-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research PYRIDINE DATE: 10/08/97
EXPERIMENT: 55301 TEST: 06 TIME: 12:24:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95268 ROUTE: DOSED WATER NTP C#: 55301B
PATHOLOGIST: D. SAUER CAS: 110-86-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research PYRIDINE DATE: 10/08/97
EXPERIMENT: 55301 TEST: 06 TIME: 12:24:06
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95268 ROUTE: DOSED WATER NTP C#: 55301B
PATHOLOGIST: D. SAUER CAS: 110-86-1
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 283 468 536 557 559 572 576 587 589 592 |
| 598 601 616 618 624 639 644 644 654 660 |
| 674 676 681 695 701 705 707 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 336 352 372 445 470 479 486 506 536 541 |
| 549 552 561 573 581 593 595 610 611 634 |
| 638 639 642 647 649 651 660 668 679 682 |
| 690 697 698 710 714 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 354 404 447 473 479 481 486 487 494 500 |
| 501 510 515 520 548 561 575 588 608 622 |
| 628 630 631 632 645 650 660 664 674 675 |
| 682 683 688 700 704 704 705 713 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 43 CENSORED DEATHS 0 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 94 443 450 463 464 466 467 468 483 486 |
| 489 493 499 511 531 532 539 545 550 552 |
| 553 553 556 562 568 574 580 582 587 595 |
| 606 616 627 629 631 658 660 674 682 683 |
| 685 687 709 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 722 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 722 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 76.0 60.0 44.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 96.0 94.0 88.0 80.0 66.0 46.0 28.0 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 98.0 96.0 88.0 72.0 64.0 44.0 22.0 |
| | |
| | |
|400 PPM | 100.0 98.0 98.0 98.0 98.0 82.0 64.0 40.0 26.0 14.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.0% 28.0% 22.0% 14.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.090 P=0.020 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.3 587.8 588.3 553.1 |
|NATURAL DEATHS (C) | (16.6) (17.1) (15.7) (15.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 661.1 625.4 617.7 576.7 |
|(STANDARD ERROR) | (12.0) (15.0) (14.5) (16.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PYRIDINE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
| 4 1 2 2 3 4 1
| 2 2 3 2 4 13 1 1
| 2 23
90 + 22 1 1
| 22 11
| 4 423 2 2 11 1
| 4433 22
80 + 22 11
| 4433
P | 4433 3 2 22 1 11
E | 4 34 3 22 11
R 70 + 3 3 2 2 1 1
C | 44 3 3
E | 444 33 2 32 1 1
N | 323 2 1 1
T 60 + 3322 1 1
|
S | 444 3322 11 1
U | 44 3 3 11
R 50 +
V | 44 2 2
I | 44 222 1 11
V | 4 4 22
A 40 + 4 4 322
L | 44 22
| 4 4 332 2
| 44 33
30 + 4 4 22
| 4 4 22
| 4 44 333
| 33
20 +
| 44
| 4 4 4
|
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 38 obs hidden.