TDMS Study 55312-03 Pathology Tables
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
2 YEAR CHRONIC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 68603-42-9
Lock Date: 09/06/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|
| 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Fibrosis | |
Hepatodiaphragmatic Nodule | X X X X X X X X|
Inflammation, Chronic | 1 2 2 2 3 1 1 2 1 2 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 1 2 2 3 1 3 1 1 1 1 2|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Hyperplasia, Adenomatous | |
Hepatocyte, Necrosis | |
Hepatocyte, Centrilobular, | |
Degeneration | 3 |
Hepatocyte, Centrilobular, Necrosis | 3 |
Serosa, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Acinus, Atrophy | 2 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Ulcer | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|
| 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 2 1 1 1 1 1 2 2|
Inflammation, Chronic Active | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 2 2 3|
Degeneration, Fatty | 1 1 1 2 1 2 1 1 2 1|
Fibrosis | 2|
Hyperplasia | 4 2 1 2 1 3 1 2 2 2|
Hypertrophy | 2 2 2 2 2 2 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + M + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 2 2 2 2 2 2 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 2 2 1 3 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 1 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Chronic Active | 1 1 2 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 4 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 4 4 4 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|
| 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | |
Inguinal, Ectasia | |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 4 |
Necrosis | |
Pigmentation, Hemosiderin | 3 |
Capsule, Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 2 1 1 1 2 2 2 1 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperkeratosis | 1 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 |
Epidermis, Skin, Site of Application,| |
Parakeratosis | |
Epidermis, Skin, Site of Application,| |
Ulcer | |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | |
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 5| 1| 2| 1| 2| 1| 2| 2| 9| 0| 2| 2| 2| 1| 2| 2| 2| 2| 8| 2|
| 2| 9| 9| 9| 9| 5| 3| 9| 9| 9| 3| 8| 2| 8| 8| 8| 9| 9| 7| 9| 9| 3| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 1 |
Inflammation, Granulomatous | 1 3 |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1|
Mediastinum, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 |
Respiratory Epithelium, Hyperplasia | 3 |
Vein, Turbinate, Septum, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Anterior Chamber, Cornea, Iris, | |
Synechia | |
Cornea, Inflammation, Chronic | |
Lens, Cataract | 2 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | 2 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy, Chronic | 1 1 2 2 2 1 1 1 2 2 2 2 1 1 2 1 2 2 1 2 2 2 2 1 2|
Pigmentation, Hemosiderin | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| |
| 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X| 31 |
Clear Cell Focus | X X | 5 |
Fibrosis | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 10 |
Inflammation, Chronic | 2 1 2 1 2 1 1 1 1 1 2 1 | 29 1.4|
Mixed Cell Focus | X | 1 |
Pigmentation, Hemosiderin | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 3 1 1 1 1 2 1| 23 1.4|
Bile Duct, Hyperplasia | 2 1 1 2 2 1 2 2 1 1 1 1 1 1 1 1| 26 1.2|
Hepatocyte, Hyperplasia, Adenomatous | 3 | 1 3.0|
Hepatocyte, Necrosis | 2 | 1 2.0|
Hepatocyte, Centrilobular, | | |
Degeneration | 2 | 2 2.5|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
Serosa, Necrosis, Fibrinoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 4 | 3 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Gingival, Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 2.0|
Acinus, Atrophy | 1 1 1 1 3 1 4 1 2 1 1 2 1 1 1| 19 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 2 | 2 2.5|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| |
| 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 2 2 2 1 1 2 1 1| 22 1.5|
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 2| 8 2.1|
Degeneration, Fatty | 2 1 1 4 4 1 2 1 1 1 2 1 | 22 1.5|
Fibrosis | | 1 2.0|
Hyperplasia | 2 2 2 2 1 2 2 1 1 2 3 2 | 22 1.9|
Hypertrophy | 2 2 2 | 10 1.9|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + + + + M + + M +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 3 2 2 2 2 2 2 1 3 3 2 2 2 2 3| 23 2.1|
Pars Distalis, Hyperplasia | 2 2 2 3 3 1 2 2 | 20 2.2|
Pars Intermedia, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 1 1 2 | 17 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 | 4 2.0|
Inflammation, Chronic Active | 2 3 3 | 6 2.0|
Duct, Cyst | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| |
| 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 7 3.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Hyperplasia | 4 3 4 4 4 4 3 | 12 3.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 41 |
Pigmentation, Hemosiderin | 1 | 1 1.0|
Inguinal, Ectasia | 2 | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 1 1 2 2 2 2 1 1 1 1 2 1 2 1 1 1 | 38 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
Necrosis | 4 | 1 4.0|
Pigmentation, Hemosiderin | | 1 3.0|
Capsule, Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + M + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hyperplasia, Cystic | 2 1 2 2 2 2 2 2 2 2 2 3 2 1 2 3 2 2 2 1 2 2| 44 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Hyperkeratosis | 2 1 | 3 1.3|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 3 | 3 2.3|
Epidermis, Skin, Site of Application,| | |
Parakeratosis | 1 | 1 1.0|
Epidermis, Skin, Site of Application,| | |
Ulcer | 4 1 | 2 2.5|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| |
| 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin, Site of Application, | | |
Inflammation, Chronic Active | 3 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 2 1 1 | 7 1.4|
Inflammation, Granulomatous | 3 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 2 | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 2 1 1 1 1 1 1| 22 1.0|
Mediastinum, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 4 1.5|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
Vein, Turbinate, Septum, Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Anterior Chamber, Cornea, Iris, | | |
Synechia | 4 | 1 4.0|
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Lens, Cataract | 2 2 3 | 5 2.6|
Retina, Atrophy | 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 3| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| 6| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 4| 2| 1| 2| 0| 2| 2| 5| 9| 2| 2| 2| 2| 6| 3| 8| 2| 3| 2| 2| 2| |
| 9| 3| 8| 9| 2| 7| 8| 9| 6| 8| 9| 2| 7| 9| 9| 9| 8| 9| 9| 5| 9| 6| 8| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Accumulation, Hyaline Droplet | 2 3 | 2 2.5|
Cyst | 2 | 2 2.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 50 1.0|
Nephropathy, Chronic | 2 2 2 2 1 2 1 2 2 1 2 2 2 1 2 1 1 2 2 1 2 2| 47 1.6|
Pigmentation, Hemosiderin | 3 1 2 1 1 1 1 1 1 1 1 1 1 3 3 1 1 1 1 2 1 2 2| 48 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|
DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|
| 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X X X|
Inflammation, Chronic | 2 1 1 1 1 1 2 1 1 1 1 1 1 1|
Mixed Cell Focus | X X|
Vacuolization Cytoplasmic | 2 1 1 1 1 2 2 2 1 1 |
Bile Duct, Hyperplasia | 2 3 1 1 2 1 1 1 2 1|
Hepatocyte, Hyperplasia, Adenomatous | 4 |
Hepatocyte, Necrosis | |
Hepatocyte, Centrilobular, | |
Degeneration | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia, Squamous | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic Active | 3 2 |
Mineralization | 3 |
Epithelium, Hyperplasia | 3 2 |
Epithelium, Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Epithelium, Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|
DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|
| 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 |
Atrophy | 2 |
Degeneration, Cystic | 1 3 3 |
Degeneration, Fatty | 2 1 2 1 1 1 1 1 |
Hyperplasia | 2 1 1 1 2 2 2 |
Hypertrophy | 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 2 3 3 2 2 2 2 2 2 1 2 1 2|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 3|
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thymus | |
C-Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 3 3 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 4 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|
DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|
| 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemosiderin | 1 2 1 2 1 1 1 2 1 1 1 1 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Epidermis, Hyperplasia | |
Epidermis, Skin, Site of Application,| |
Hyperkeratosis | 2 2 1 2 1 2 2 1 1 2 4 1 2 1 2 2 1 2 1 2 1 1 1|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 2 2 2 2 1 1 3 2 2 1 2 2 3 2 1 1 1 2 2 2 1 2|
Epidermis, Skin, Site of Application,| |
Parakeratosis | 2 1 1 2 1 1|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 2 2 2 1 2 1 1 1 2 2 1 2 2 2 2 1 1 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Chronic Active | 1 2 1 1 1 1|
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 5| 6| 5| 7| 7| 5| 7| 3| 6| 7| 7| 4| 6| 7| 7| 2| 2| 5|
DAY ON TEST | 2| 2| 9| 2| 3| 2| 7| 3| 8| 1| 2| 2| 3| 2| 8| 9| 2| 2| 7| 8| 2| 2| 7| 2| 7|
| 2| 8| 0| 9| 7| 8| 8| 3| 9| 4| 9| 9| 3| 8| 2| 2| 8| 9| 6| 9| 9| 8| 1| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 3 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Nephropathy, Chronic | 2 1 1 3 2 2 2 1 2 2 2 2 2 1 2 3 3 2 3 2 2 1|
Pigmentation, Hemosiderin | 1 1 2 1 1 3 1 1 1 1 2 1 1 1 1 2 1 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| |
DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| |
| 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X| 17 |
Clear Cell Focus | X X X | 4 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X | 11 |
Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 2 2 1| 26 1.2|
Mixed Cell Focus | | 2 |
Vacuolization Cytoplasmic | 2 1 2 1 1 1 1 2 2 1| 20 1.4|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | 21 1.2|
Hepatocyte, Hyperplasia, Adenomatous | | 1 4.0|
Hepatocyte, Necrosis | 3 2 | 2 2.5|
Hepatocyte, Centrilobular, | | |
Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Fat, Necrosis | 4 4 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Hyperplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 3 2 | 13 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 3 2.3|
Mineralization | | 1 3.0|
Epithelium, Hyperplasia | 3 2 3 | 5 2.6|
Epithelium, Ulcer | 4 | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| |
DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| |
| 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Erosion | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 1 1 2 2 1 1 2 2 1 2 2| 16 1.6|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 3.0|
Atrophy | | 1 2.0|
Degeneration, Cystic | 2 3 2 | 6 2.3|
Degeneration, Fatty | 1 2 2 1 1 1 | 14 1.3|
Hyperplasia | 2 2 1 1 2 1 2| 14 1.6|
Hypertrophy | 3 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + M + + M + + + + + + + + +| 46 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 2 2 3 2 2 2 2 2 2 4 3 2| 27 2.2|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 3| 19 2.1|
Pars Intermedia, Cyst | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Thymus | 3 | 1 3.0|
C-Cell, Hyperplasia | 1 2 1 | 7 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 1 2 | 6 2.2|
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| |
DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| |
| 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 4 2 4 4 | 8 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 4 4 4 4 4 | 14 3.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 36 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 2 2 1 2 1 1 2 2 2 2 1 2 1 1 1 1 1 1| 35 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 3 4.0|
Hyperplasia, Cystic | 2 2 2 2 2 4 2 2 2 2 2 3 1 1 1 1 3 2 1 2 2 2 2| 40 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Epidermis, Hyperplasia | 3 | 1 3.0|
Epidermis, Skin, Site of Application,| | |
Hyperkeratosis | 2 2 2 1 2 2 1 1 1 2 2 1 2 2 1 2 2 2 1 1 1 2| 45 1.6|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 2 2 1 1 2 2 2 1 1 2 1 1 1 2 2 2 2 2 1 2 2 2| 46 1.7|
Epidermis, Skin, Site of Application,| | |
Parakeratosis | 1 1 1 1 1 | 11 1.2|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 2 2 1 2 2 2 1 2 1 1 1 2 2 2 2 2 1 2 2 2| 46 1.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 | 2 2.5|
Osteopetrosis | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 6| 7| 7| 2| 7| 7| |
DAY ON TEST | 8| 2| 6| 2| 2| 2| 1| 1| 8| 2| 2| 0| 2| 2| 2| 2| 1| 0| 5| 7| 2| 2| 8| 2| 2| |
| 5| 9| 2| 8| 9| 9| 2| 9| 2| 9| 9| 8| 9| 9| 9| 9| 2| 8| 1| 7| 9| 9| 0| 8| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic Active | 1 2 1 1 1 1 2 2 2 1 | 16 1.3|
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1| 24 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 3 | 4 2.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 3 2.3|
Respiratory Epithelium, Hyperplasia | 2 3 | 4 2.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Nephropathy, Chronic | 3 2 4 1 2 2 2 2 2 1 2 1 2 2 2 3 1 3 2 2 4 2 3 2| 46 2.1|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2| 46 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|
DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|
| 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Chronic | 1 2 1 1 1 1 |
Vacuolization Cytoplasmic | 3 1 3 1 1 1 1 2 3 1 1 2 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Degeneration, Cystic | 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 4 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Inflammation, Chronic | |
Active | |
Pharyngeal, Hyperplasia, Squamous | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 4 |
Inflammation, Chronic Active | 3 3 3 2 3 3 |
Epithelium, Hyperplasia | 2 3 3 3 3 3 3 4 |
Epithelium, Ulcer | 2 4 4 4 4 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Epithelium, Erosion | 2 |
Epithelium, Hyperplasia | 2 |
Glands, Hyperplasia | |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|
DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|
| 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 2 |
Pulmonary Artery, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 2 3 2 1 1 |
Mineralization | 1 |
Atrium, Thrombosis | 4 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 2 2 2 |
Degeneration, Fatty | 3 2 1 2 1 2 1 2 2 |
Hyperplasia | 1 1 2 2 1 2 |
Hypertrophy | 1 3 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + M M + + + + + + M + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 2 2 2 1 2 2 |
Pars Distalis, Hyperplasia | 2 3 2 2 3 4 2 2 2 2 2 |
Pars Intermedia, Cyst | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 1 2 2 2 1 |
Bilateral, Duct, Cyst | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|
DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|
| 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 3 4 4 4 4 3 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 3 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 1 3 2 2 2 4 2 2 2 3 2 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Epidermis, Skin, Site of Application,| |
Hyperkeratosis | 2 2 2 2 3 1 2 2 2 2 3 2 2 2 2 2 1 2 2 2 1 2 2 1|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 3 2 3 2 3 3 3 2 2 3 3 3 2 2 2 2 2 1 3 3 3 1 3 2 2|
Epidermis, Skin, Site of Application,| |
Parakeratosis | 2 1 3 1 3 2 2 2 3 2 2 1 2 2 |
Epidermis, Skin, Site of Application,| |
Ulcer | 3 2 4 2 1 |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 2 2 2 2 2 3 2 2 2 3 2 2 2 1 2 2 1 3 3 2 1 3 3 2|
Skin, Site of Application, | |
Inflammation, Chronic Active | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 |
Inflammation, Granulomatous | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 3| 7| 6| 7| 6| 5| 4| 6| 7| 3| 7| 7| 7| 7| 3| 7| 6| 2|
DAY ON TEST | 2| 2| 8| 2| 1| 1| 2| 7| 2| 6| 2| 2| 3| 6| 7| 2| 8| 2| 2| 2| 2| 7| 2| 6| 9|
| 4| 9| 9| 9| 5| 8| 6| 3| 8| 9| 9| 0| 6| 6| 2| 9| 7| 9| 8| 9| 8| 7| 8| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
Respiratory Epithelium, Hyperplasia | 3 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Bilateral, Inflammation, Suppurative | 4 |
Lens, Cataract | 2 |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2|
Nephropathy, Chronic | 3 4 4 4 4 4 3 2 2 3 3 3 2 2 2 4 1 3 3 3 2 2 2 1|
Pigmentation, Hemosiderin | 2 2 1 2 1 1 1 1 2 2 1 1 1 2 2 1 2 1 1 3 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| |
| 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X| 4 |
Clear Cell Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X X X X X X | 14 |
Inflammation, Chronic | 2 1 1 1 1 1 1 | 13 1.2|
Vacuolization Cytoplasmic | 1 1 1 2 3 1 1 2 1| 22 1.5|
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 | 16 1.1|
Hepatocyte, Degeneration, Cystic | | 1 1.0|
Hepatocyte, Centrilobular, | | |
Degeneration | | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Inflammation, Chronic Active | 4 | 1 4.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 3 |
Gingival, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Pharyngeal, Hyperplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 1 1 | 11 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 3.5|
Inflammation, Chronic Active | 3 3 2 3 | 10 2.8|
Epithelium, Hyperplasia | 4 2 3 2 3 | 13 2.9|
Epithelium, Ulcer | 4 4 3 4 | 11 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Epithelium, Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| |
| 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | | 1 2.0|
Glands, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Hyperplasia, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 2.0|
Pulmonary Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 1 2 2 1 1 1| 14 1.5|
Mineralization | | 1 1.0|
Atrium, Thrombosis | | 3 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 1 3 3 | 8 2.1|
Degeneration, Fatty | 1 3 3 2 3 2 2 | 16 2.0|
Hyperplasia | 2 1 3 3 2 | 11 1.8|
Hypertrophy | 3 1 | 7 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 2 2 1 2 2 2 2 2 | 17 1.9|
Pars Distalis, Hyperplasia | 2 2 1 2 2 1 2 3 | 19 2.2|
Pars Intermedia, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1| 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 3 2.0|
Inflammation, Chronic Active | 1 | 8 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| |
| 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Duct, Cyst | 3 | 1 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 3 2 | 8 2.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 10 3.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 36 |
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 1 1 2 1 2 1 1 1 2 2 2 1 1 1| 34 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Capsule, Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 1 2 2 2 2| 40 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 1.5|
Epidermis, Skin, Site of Application,| | |
Hyperkeratosis | 2 2 2 2 1 2 1 1 2 1 1 2 2 1 2 1 2 1 1 1 2 2 2| 47 1.7|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 3 3 3 2 3 1 2 2 3 2 2 2 3 2 3 1 2 2 4 1 1 2 2 3| 50 2.3|
Epidermis, Skin, Site of Application,| | |
Parakeratosis | 2 1 3 1 1 2 2 3 3 | 23 2.0|
Epidermis, Skin, Site of Application,| | |
Ulcer | 2 2 2 2 | 9 2.2|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 3 3 1 3 1 1 1 3 1 1 2 2 2 3 1 2 1 3 2 2 2 3| 49 2.0|
Skin, Site of Application, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 7| 3| 7| 7| 3| 6| 7| 6| 4| 5| 7| 5| 7| 7| 2| 5| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 4| 1| 2| 2| 0| 2| 2| 7| 6| 2| 3| 7| 8| 2| 5| 2| 2| 7| 3| 2| 2| 2| 2| 0| 2| |
| 5| 4| 8| 9| 8| 8| 9| 4| 6| 9| 9| 9| 8| 8| 7| 8| 8| 1| 7| 9| 9| 9| 2| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 1 2 2 1 | 9 1.4|
Inflammation, Granulomatous | 1 | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 3 2.3|
Respiratory Epithelium, Hyperplasia | 2 | 3 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Bilateral, Inflammation, Suppurative | | 1 4.0|
Lens, Cataract | 3 4 4 | 4 3.3|
Retina, Atrophy | 4 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Mineralization | 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1| 47 1.2|
Nephropathy, Chronic | 2 3 1 3 3 2 3 1 2 4 4 2 3 3 1 3 3 3 2 2 3 3| 46 2.7|
Pigmentation, Hemosiderin | 1 1 2 1 1 2 1 1 1 2 1 1 1 1 1 2 2 3 1 1 1 1 1| 47 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|
DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|
| 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 |
Mineralization | |
Vacuolization Cytoplasmic | 1 2 2 1 1 1 1 3 2 2 2 2 1 1|
Bile Duct, Hyperplasia | 3 1 1 1 2 1 2 1 2 2 2 1 1 2 2 3 1 2 2 1 2 2 2|
Hepatocyte, Degeneration, Cystic | 1 1 1 2 1 1 1 |
Hepatocyte, Necrosis | 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 3|
Hepatocyte, Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 4 4|
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 1 2 1 1 |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 3 |
Inflammation, Chronic Active | 2 2 2 2 2 |
Mineralization | 3 3 3 2 |
Perforation | X |
Epithelium, Hyperplasia | 3 2 2 3 3 3 3 3 |
Epithelium, Ulcer | 4 4 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 3 3 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|
DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|
| 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Aorta, Mineralization | 3 3 2 4 3 |
Pulmonary Artery, Mineralization | 3 3 4 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 3 2 3 2 2 2 1 3 2 2 2 2 3 3 2 |
Inflammation, Suppurative | |
Mineralization | 3 2 3 2 |
Atrium, Thrombosis | 3 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Degeneration, Fatty | 1 2 1 1 2 2 1 2 1 2 2 2 2 2 1 1 1|
Hyperplasia | 1 1 1 2 2 2 2 |
Hypertrophy | 1 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 1 1 1 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 2 2 3 3 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 3 2 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 |
Follicle, Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 1 1 2 2 2 1 2 3 2 2 1 2 2 2 1 1 2 2 2 2 2 3 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | 4 2 3 2 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|
DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|
| 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 3 2 2 2 2 2 2 3 2 2 2 1 2 3 2 1 2 4 3 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | 2 3 2 2 |
Arteriole, Necrosis, Fibrinoid | 2 3 2 2 |
Bilateral, Germinal Epithelium, | |
Atrophy | 4 |
Germinal Epithelium, Atrophy | 4 4 4 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 4 3 3 4 4 4 3 4 4 3 3 2 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis | |
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Hyperplasia, Cystic | 1 3 2 2 3 2 2 1 1 4 2 2 2 2 2 2 2 3 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Callus | |
Fibrous Osteodystrophy | 3 4 4 3 4 4 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 5| 6| 6| 4| 6| 5| 6| 6| 7| 6| 6| 7| 4| 5| 7| 3| 7| 6| 6| 5| 7| 6| 5| 4| 5|
DAY ON TEST | 2| 3| 5| 4| 3| 9| 1| 7| 2| 5| 4| 1| 6| 6| 2| 9| 2| 1| 2| 9| 2| 0| 8| 5| 4|
| 1| 1| 6| 2| 2| 1| 8| 7| 9| 0| 0| 3| 3| 3| 9| 2| 9| 7| 1| 3| 9| 3| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | 1 1 |
Inflammation, Suppurative | 3 |
Mineralization | 3 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1|
Interstitium, Mineralization | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 2 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 3 3 2 3 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 4 2 |
Vein, Turbinate, Septum, Thrombosis | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 3 2 3 |
Hydronephrosis | |
Mineralization | 2 2 3 |
Nephropathy, Chronic | 2 2 3 3 4 2 4 4 2 3 3 4 3 3 3 2 2 4 4 4 3 4 2 2 2|
Pigmentation, Hemosiderin | 3 1 1 1 1 1 2 2 1 1 1 3 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| |
DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| |
| 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 3| 2 3.5|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | | 3 |
Hepatodiaphragmatic Nodule | X X X X X X | 9 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 | 20 1.1|
Mineralization | 1 | 1 1.0|
Vacuolization Cytoplasmic | 2 3 1 1 3 1 1 1 1 1 1 2 1| 27 1.5|
Bile Duct, Hyperplasia | 1 2 2 1 1 2 1 3 3 2 3 2 3 1 1 1 2 1 1 2 2 2 1 2| 47 1.7|
Hepatocyte, Degeneration, Cystic | 2 | 8 1.3|
Hepatocyte, Necrosis | | 1 1.0|
Hepatocyte, Centrilobular, | | |
Degeneration | 3 | 2 3.0|
Hepatocyte, Centrilobular, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + + +| 8 |
Inflammation, Chronic Active | 3| 1 3.0|
Fat, Necrosis | 4 4 4 | 7 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1| 11 1.4|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 3 | 6 3.0|
Inflammation, Chronic Active | 2 2 2 3 3 4 3 3 3 2| 15 2.5|
Mineralization | | 4 2.8|
Perforation | X X X| 4 |
Epithelium, Hyperplasia | 3 3 2 3 3 4 2 3 2 3| 18 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| |
DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| |
| 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Ulcer | 4 4 4 4 4 4 4 4 4 | 13 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 1 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Aorta, Mineralization | 3 | 6 3.0|
Pulmonary Artery, Mineralization | | 4 3.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 2 2 1 2 2 2 2 2 3 2 1 2 2 2 2 1 1 | 37 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 1 | 5 2.2|
Atrium, Thrombosis | 4 3 2 | 6 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 | 3 2.0|
Degeneration, Fatty | 1 1 1 2 1 1 1 2 1 2 1 2 1 1 2 1 1 2 2| 36 1.4|
Hyperplasia | 2 2 2 2 2 2| 13 1.8|
Hypertrophy | 1 | 2 1.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 1 2 3 2 2 2| 20 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 3 2 2| 14 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 1 2 1 2 3 1 2 1 2 2| 16 1.8|
Pars Distalis, Hyperplasia | 1 2 2 2 1 2 3| 13 2.0|
Pars Intermedia, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 | 6 1.5|
Follicle, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| |
DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| |
| 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 2.0|
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 2 2 3 1 2 2 2 3 1 2 2 2 1| 47 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Multilocular | 2 3 2 1 | 9 2.3|
Inflammation, Chronic Active | 2 2 1 3 2 3 2 2 2 1 2 2 3 3 2 2 2 3 2 1 3 1 2| 46 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | 2 2 2 2 1| 9 2.0|
Arteriole, Necrosis, Fibrinoid | 2 2 2 2 1| 9 2.0|
Bilateral, Germinal Epithelium, | | |
Atrophy | | 1 4.0|
Germinal Epithelium, Atrophy | 4 3 4 4 4 4| 10 3.8|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 | 12 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia | 4 4 4 4 4 4 3 3| 22 3.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 35 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 1 1 1 1 2 1 1 1 1 2 1 1 1| 29 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Ectasia | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 3 1 | 6 2.2|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | 2 | 1 2.0|
Red Pulp, Depletion Cellular | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| |
DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| |
| 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Cyst | | 2 3.0|
Hyperplasia, Cystic | 3 3 2 3 3 2 3 2 3 2 2 3 2 2 2| 36 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Prepuce, Inflammation, Chronic Active| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Callus | 4 | 1 4.0|
Fibrous Osteodystrophy | 3 2 | 10 3.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Inflammation, Granulomatous | | 2 1.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 2 | 7 1.1|
Interstitium, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 3 3 | 9 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 2 2.5|
Respiratory Epithelium, Hyperplasia | 3 3 3 3 | 9 2.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 2.7|
Vein, Turbinate, Septum, Thrombosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 4| 1| 5| 5| 7| 3| 6| 3| 6| 7| 4| 7| 4| 6| 7| 7| 5| 5| 7| 7| 6| 6| 5| 5| 7| |
DAY ON TEST | 6| 1| 8| 5| 1| 3| 1| 8| 4| 2| 9| 2| 7| 8| 0| 2| 6| 4| 2| 2| 0| 6| 8| 2| 0| |
| 7| 0| 9| 6| 3| 4| 8| 9| 2| 9| 5| 3| 0| 0| 5| 9| 1| 0| 9| 9| 7| 8| 3| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 3 | 2 3.5|
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 | 8 2.6|
Hydronephrosis | 2 | 1 2.0|
Mineralization | | 3 2.3|
Nephropathy, Chronic | 2 3 2 4 1 3 1 4 3 1 3 2 4 4 3 1 2 3 3 2 4 2 4 4| 49 2.8|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1| 43 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 3 | 2 2.5|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|
DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|
| 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | |
Fibrosis | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 2 2 1 2 1 1 1 1 1 1 1 1|
Vacuolization Cytoplasmic | 3 3 2 2 1 3 1 2 2 1 1 1 2 2 1 1 1 1 |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 2 2 2 2 2 2 2 1 1 2 2 2 1 2 1 2 2 1|
Hepatocyte, Degeneration, Cystic | 2 1 2 1 |
Hepatocyte, Necrosis | 2 2 |
Hepatocyte, Centrilobular, | |
Degeneration | 2 |
Hepatocyte, Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | |
Inflammation, Chronic Active | 3 |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Hyperplasia | |
Gingival, Inflammation, Chronic | |
Active | |
Pharyngeal, Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 1 1 2 1 2 2 1 4 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 2 |
Inflammation, Chronic Active | 3 2 3 3 |
Mineralization | |
Perforation | X |
Epithelium, Hyperplasia | 3 2 3 3 3 3 2 |
Epithelium, Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|
DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|
| 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 2 2 2 2 2 2 1 2 1 1 2 2 1 2 1 2 1 1 2 |
Mineralization | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Degeneration, Cystic | 2 2 1 |
Degeneration, Fatty | 2 1 2 1 1 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2 |
Hyperplasia | 2 2 2 2 2 1 1 1 1 2 2 1 2 2 |
Hypertrophy | 2 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + M|
Hyperplasia | 2 2 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hematoidin | 3 |
Pars Distalis, Cyst | 2 1 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1 3 2 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | 2 2 2 1 2 |
Inflammation, Chronic Active | 4 4 2 2 2 2 2 2 2 2 2 2 1 2 2 2 3 2 3 4 2 2 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|
DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|
| 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | 1 1 2 2 2 2 |
Arteriole, Necrosis, Fibrinoid | 1 2 2 2 2 |
Germinal Epithelium, Atrophy | 4 4 2 4 4 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 4 4 3 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + M + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia, Cystic | 1 2 2 1 2 2 1 2 2 2 1 2 3 3 2 1 4 2 2 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epidermis, Skin, Site of Application,| |
Hyperkeratosis | 2 1 2 2 2 2 2 2 2 2 1 1 1 1 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 1 1 1 1 1 1 1 2 1 1 2 1 2 1 2 2 1 2 1 2 1|
Epidermis, Skin, Site of Application,| |
Parakeratosis | 1 1 1 |
Epidermis, Skin, Site of Application,| |
Ulcer | |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 1 1 1 1 1 1 2 1 2 2 1 2 1 2 2 1 1 2 2 1|
Skin, Site of Application, Hemorrhage| |
Skin, Site of Application, | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 6| 5| 4| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 5| 4| 5| 7| 4|
DAY ON TEST | 2| 8| 1| 8| 2| 7| 2| 2| 7| 1| 2| 1| 2| 5| 2| 2| 2| 2| 2| 2| 3| 9| 8| 2| 4|
| 0| 9| 7| 6| 9| 9| 6| 3| 4| 7| 9| 1| 9| 8| 0| 9| 9| 9| 0| 5| 4| 9| 0| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
50 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 4 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 |
Interstitium, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 1 |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Respiratory Epithelium, Hyperplasia | 3 3 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 |
Cyst | 3 2 3 2 |
Mineralization | |
Nephropathy, Chronic | 4 1 4 2 3 2 2 2 2 3 4 2 2 2 4 2 3 3 3 3 2 1 2 2 2|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| |
| 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X| 13 |
Clear Cell Focus | X X X X | 6 |
Eosinophilic Focus | X | 1 |
Fibrosis | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X | 9 |
Inflammation, Chronic | 1 1 2 1 1 1 1 1 1 1 1| 25 1.2|
Vacuolization Cytoplasmic | 1 1 1 2 2 1 2 2 1 2 1 1 2 1 3 2 2 1| 36 1.6|
Bile Duct, Hyperplasia | 1 1 1 2 2 2 1 2 2 1 3 1 3 1 1 1 1 1 2 1 1 2 1 1| 48 1.6|
Hepatocyte, Degeneration, Cystic | 1 1 1 1 | 8 1.3|
Hepatocyte, Necrosis | 1 | 3 1.7|
Hepatocyte, Centrilobular, | | |
Degeneration | | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Accessory Spleen | X | 1 |
Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | 4 | 3 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 2 |
Gingival, Hyperplasia | 3 | 1 3.0|
Gingival, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Pharyngeal, Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 1 3 1 2 1 2| 22 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 4| 5 2.8|
Inflammation, Chronic Active | 4 3 2 3| 8 2.9|
Mineralization | 1 3 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| |
| 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perforation | X | 2 |
Epithelium, Hyperplasia | 3 3 3 3 3 2 3 2 3| 16 2.8|
Epithelium, Ulcer | 4 4 4 4| 7 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 3 3 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 3 2 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 2 2 2 2 1 2 2 1 2 2 2 2 3 1 1 2 4 3 2 2| 43 1.8|
Mineralization | 3 3 1 | 3 2.3|
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Degeneration, Cystic | 2 | 4 1.8|
Degeneration, Fatty | 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 2 2 2 1 3 | 40 1.6|
Hyperplasia | 2 1 1 2 2 1 2 | 21 1.6|
Hypertrophy | 2 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 1 1 2 2 1 1 2 2 1 2| 19 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + M + + + + + + +| 46 |
Hyperplasia | 2 3 2 2 3 3 3 3 3 2 | 15 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hematoidin | | 1 3.0|
Pars Distalis, Cyst | 2 1 2 3 | 7 1.9|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3| 10 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 1 | 11 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| |
| 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 3 2 3 2| 46 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Multilocular | 1 2 1 | 8 1.6|
Inflammation, Chronic Active | 3 2 3 2 2 2 2 2 2 2 1 2 4 2 3 2 2 4 2 2 4 2| 47 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | 2 2 1 2 2 | 11 1.7|
Arteriole, Necrosis, Fibrinoid | 2 2 1 2 2 | 10 1.8|
Germinal Epithelium, Atrophy | 4 4 4 4 2 4 4 4 4 | 15 3.6|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 | 12 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 3 4 4 3 3 4 3 4 4 4 2 | 22 3.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 30 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 2 1 1 1 1 1 1 2 2 | 26 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3| 5 2.8|
Hematopoietic Cell Proliferation | 2 | 3 2.7|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + M +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 4 4 4 4 4 | 6 4.0|
Hyperplasia, Cystic | 2 3 3 2 2 3 2 3 3 3 2 1 2 2 3 3 3 3 3 2 2 2| 44 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| |
| 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Skin, Site of Application,| | |
Hyperkeratosis | 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1 1 2 2 1 2| 36 1.4|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 2 1 2 2 2 2 2 1 2 1 2 2 2 1 2 1 1 2 1 1 2 2 2| 46 1.5|
Epidermis, Skin, Site of Application,| | |
Parakeratosis | 2 1 1 2 1 1 | 9 1.2|
Epidermis, Skin, Site of Application,| | |
Ulcer | 2 | 1 2.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 1 2 1 2 2 1 2 2 1 2 1 2 2 2 1 2 1 1 2 1 1 1 2 2| 45 1.5|
Skin, Site of Application, Hemorrhage| 4 | 1 4.0|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 3 2 4 4 4 4 2 | 12 2.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic Active | 1 2 3 1 2 3 3 | 8 2.0|
Alveolar Epithelium, Hyperplasia | 1 4 2 | 4 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 | 13 1.0|
Interstitium, Mineralization | 3 2 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 3 | 7 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 3 | 4 2.3|
Respiratory Epithelium, Hyperplasia | 2 2 3 | 7 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 5| 7| 6| 7| 3| 4| 6| 6| 6| 6| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 1| 2| 2| 7| 2| 8| 2| 8| 9| 7| 5| 0| 2| 5| 9| 2| 1| 7| 6| 7| 0| 2| 1| 1| 2| |
| 1| 9| 9| 4| 9| 6| 9| 0| 5| 0| 6| 0| 1| 6| 5| 9| 3| 7| 1| 5| 8| 8| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
50 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cornea, Inflammation, Chronic Active | 2 | 1 2.0|
Cornea, Mineralization | 3 | 1 3.0|
Lens, Cataract | 3 | 2 3.0|
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 2.0|
Cyst | 2 2 3 3 3 | 9 2.6|
Mineralization | 2 2 1 | 3 1.7|
Nephropathy, Chronic | 1 1 3 3 2 3 4 1 2 2 2 2 2 4 4 4 4 3 3 4 4 4 2 3 4| 50 2.7|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Renal Tubule, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | X | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|
| 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 1 2 1 1 1 1 1 2 2 |
Vacuolization Cytoplasmic | 3 2 1 2 1 1 1 1 2 2 1 2 2 2 1 |
Bile Duct, Hyperplasia | 2 2 1 2 2 1 1 2 2 2 2 2 1 1 3 1 1 3 1 2 1 1 2 2 2|
Hepatocyte, Degeneration, Cystic | 1 1 |
Hepatocyte, Necrosis | 2 |
Portal Vein, Thrombosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 2 1 1 1 1 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 2 3 2 |
Foreign Body | X |
Inflammation, Chronic Active | 3 3 3 3 3 3 3 3 |
Mineralization | |
Perforation | X X X |
Epithelium, Hyperplasia | 3 3 3 3 2 3 2 3 3 |
Epithelium, Ulcer | 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
Mineralization | |
Epithelium, Erosion | 2 3 |
Epithelium, Ulcer | 2 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|
| 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Aorta, Mineralization | |
Pulmonary Artery, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
Mineralization | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atypia Cellular | 1 |
Degeneration, Cystic | 2 1 |
Degeneration, Fatty | 2 1 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 |
Hyperplasia | 1 2 2 2 1 2 1 2 1 1 1 2|
Hypertrophy | 3 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + M + + + + + + + M + + + + M|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 2 1 2 2 2 2 1 3 2 2 3 2 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | 2 2 3 |
Inflammation, Chronic Active | 2 4 2 2 2 2 2 2 2 3 4 1 2 2 2 3 2 1 2 3 2 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | 2 2 3 2 2 |
Arteriole, Necrosis, Fibrinoid | 2 2 3 2 2 |
Bilateral, Germinal Epithelium, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|
| 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Germinal Epithelium, Atrophy | 4 3 4 4 3 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 4 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 1 1 1 1 2 2 1 1 3 1 2 1 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 3 |
Hyperplasia, Cystic | 2 2 2 2 3 4 2 3 2 3 1 2 2 1 3 1 2 3 2 3 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperkeratosis | 4 |
Epidermis, Hyperplasia | 4 |
Epidermis, Skin, Site of Application,| |
Hyperkeratosis | 2 2 1 2 2 1 1 2 1 2 2 1 2 2 2 2 3 2 2 2 3 2 2|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 2 1 2 3 2 3 3 1 3 2 2 2 3 3 3 2 2 3 2 3 3 3 3 2|
Epidermis, Skin, Site of Application,| |
Parakeratosis | 2 2 1 1 2 1 2 2 2 2 2 2 2 2 2 |
Epidermis, Skin, Site of Application,| |
Ulcer | 1 |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 2 1 2 2 2 3 3 1 2 2 2 2 3 3 3 2 2 3 2 2 2 3 3 2|
Skin, Site of Application, | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
_____________________________________________________________________________________________________________________
| 6| 7| 5| 6| 7| 5| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7| 5| 5| 5| 7| 6| 7| 5| 6| 7|
DAY ON TEST | 8| 2| 6| 8| 2| 0| 6| 7| 0| 1| 2| 0| 0| 8| 2| 2| 6| 5| 8| 2| 9| 2| 2| 0| 2|
| 7| 9| 5| 8| 9| 5| 0| 9| 7| 1| 9| 8| 1| 6| 7| 9| 2| 2| 2| 9| 8| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1|
Interstitium, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 4 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 2 4 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Vein, Turbinate, Septum, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + +|
Lens, Cataract | 4 4 3 4 4 4|
Retina, Atrophy | 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | 2 2 3 |
Mineralization | |
Nephropathy, Chronic | 3 3 3 4 2 2 2 2 2 4 2 3 3 3 4 2 2 2 3 4 4 2 3 2|
Pigmentation, Hemosiderin | 3 1 1 1 1 1 1 2 1 1 2 1 1 2 3 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| |
DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| |
| 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X | 2 |
Hepatodiaphragmatic Nodule | X X X X | 8 |
Inflammation, Chronic | 1 1 1 1 1 2 2 1 3 1 1 1 2| 24 1.3|
Vacuolization Cytoplasmic | 3 1 3 2 1 1 3 1 3 2 2 3 2 2 3 2 2 1| 33 1.8|
Bile Duct, Hyperplasia | 2 1 1 1 2 2 2 2 2 2 2 2 2 3 1 2 1 2 2 3 1 1 2 1 2| 50 1.7|
Hepatocyte, Degeneration, Cystic | 2 | 3 1.3|
Hepatocyte, Necrosis | | 1 2.0|
Portal Vein, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 4 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 2 |
Gingival, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 3 4 2 1 1 2 1 2 2 1 2| 25 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 2 3 | 8 2.4|
Foreign Body | | 1 |
Inflammation, Chronic Active | 3 4 3 2 2 3 | 14 2.9|
Mineralization | 1 3 | 2 2.0|
Perforation | X | 4 |
Epithelium, Hyperplasia | 3 3 3 2 3 1 2 2 4 | 18 2.7|
Epithelium, Ulcer | 4 4 4 3 4 4 | 13 3.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 3.0|
Mineralization | 3 2 3 2 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| |
DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| |
| 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Erosion | | 2 2.5|
Epithelium, Ulcer | | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | 3 3 3 3 | 4 3.0|
Pulmonary Artery, Mineralization | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 1 2 2 1 2 2 3 2 2 3 1 3 1 2 3 2 2| 42 1.9|
Mineralization | 3 2 3 1 | 4 2.3|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Atypia Cellular | | 1 1.0|
Degeneration, Cystic | 2 | 3 1.7|
Degeneration, Fatty | 2 1 1 2 1 1 2 1 2 1 1 1 1 2 2 1 1 2 1 2 1| 38 1.3|
Hyperplasia | 2 2 2 2 1 2 1 2 2 2 2 1| 24 1.6|
Hypertrophy | 2 2 2 | 5 2.2|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 2 2 1 2 2 1 | 16 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 2 2 3 3 4 3 | 8 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Pars Distalis, Cyst | 3 2| 3 2.3|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 3 3| 12 2.3|
Pars Intermedia, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 2| 11 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| |
DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| |
| 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 3 1.7|
Inflammation, Chronic Active | 2 2 1 2 2 2 1 2 2 2 2 2 2 1 2 2 4 2 1 2 2 2 2| 46 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Multilocular | 3 | 4 2.5|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 1 3 2 4 2 3 2 2 2 2 2 2| 46 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | 2 2 2 2 2 2 2 2 | 13 2.1|
Arteriole, Necrosis, Fibrinoid | 2 2 2 2 2 2 2 2 | 13 2.1|
Bilateral, Germinal Epithelium, | | |
Atrophy | 4 | 1 4.0|
Germinal Epithelium, Atrophy | 4 2 2 4 3 2 4 2 4 4 | 16 3.3|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 | 13 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 4 4 4 3 4 3| 16 3.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 37 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 33 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 | 3 2.7|
Hyperplasia, Lymphoid | 4| 1 4.0|
Red Pulp, Depletion Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Ectopic Parathyroid Gland | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 4 3.3|
Hyperplasia, Cystic | 2 2 1 2 3 2 3 2 1 4 2 2 2 2 3 2 2 3 2 1 | 43 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperkeratosis | | 1 4.0|
Epidermis, Hyperplasia | | 1 4.0|
Epidermis, Skin, Site of Application,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| |
DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| |
| 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 2 1 2 2 3 1 3 2 2 2 2 1 1 3 2 1 2 1 2 2 2 2 2 2 2| 48 1.9|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 2 3 3 3 3 3 2 2 2 2 2 1 3 1 3 2 2 2 3 2 2 3 2 3| 50 2.4|
Epidermis, Skin, Site of Application,| | |
Parakeratosis | 2 2 2 2 1 3 1 2 2 3 2 2 1| 28 1.9|
Epidermis, Skin, Site of Application,| | |
Ulcer | | 1 1.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 3 3 3 3 2 2 2 2 2 2 1 2 1 2 2 2 1 3 2 2 1 2 3| 50 2.2|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 4 3 | 6 3.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 | 12 1.0|
Interstitium, Mineralization | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2 3 2 2 | 10 2.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 3 | 4 2.8|
Respiratory Epithelium, Hyperplasia | 3 3 3 3 3 2 3 | 9 2.9|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 2 | 3 2.3|
Vein, Turbinate, Septum, Thrombosis | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
NTP Experiment-Test: 55312-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 01/28/99
Route: SKIN APPLICATION Time: 08:08:22
__________________________________________________________________________________________________________________________________
| 6| 6| 3| 5| 6| 4| 6| 7| 4| 6| 7| 6| 6| 7| 6| 6| 7| 5| 6| 6| 4| 3| 6| 7| 7| |
DAY ON TEST | 9| 2| 2| 6| 3| 7| 7| 2| 8| 2| 2| 2| 6| 1| 9| 9| 0| 9| 5| 4| 2| 8| 7| 2| 2| |
| 0| 1| 9| 0| 2| 4| 7| 9| 5| 6| 9| 0| 6| 9| 5| 8| 2| 3| 6| 0| 1| 9| 4| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Lens, Cataract | 4 4 | 8 3.9|
Retina, Atrophy | 4 4 | 8 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 2 | 1 2.0|
Cyst | 2 2 3 2| 7 2.3|
Mineralization | 3 3 2 | 3 2.7|
Nephropathy, Chronic | 2 3 1 2 3 2 3 3 2 4 2 4 4 3 2 3 4 3 4 2 2 1 4 2 2| 49 2.7|
Pigmentation, Hemosiderin | 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 4 1 1 1 1 1| 50 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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