TDMS Study 55312-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus COCONUT OIL ACID DIETHANOLAMINE CONDENSATE DATE: 02/24/99
EXPERIMENT: 55312 TEST: 03 TIME: 13:48:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-15314 ROUTE: SKIN APPLICATION NTP C#: 55312B
PATHOLOGIST: TOFT, J. CAS: 68603-42-9
------------------------------------------------------------------------------------------------------------------------------------
2 YEAR CHONIC RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus COCONUT OIL ACID DIETHANOLAMINE CONDENSATE DATE: 02/24/99
EXPERIMENT: 55312 TEST: 03 TIME: 13:48:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-15314 ROUTE: SKIN APPLICATION NTP C#: 55312B
PATHOLOGIST: TOFT, J. CAS: 68603-42-9
COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 41 CENSORED DEATHS 1 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 334 389 392 442 458 463 467 470 495 521 |
| 526 540 543 556 561 563 583 583 589 591 |
| 593 603 607 617 618 618 621 631 632 640 |
| 642 650 656 668 677 680 702 705 713 713 |
| 723 |
| CENSORED DEATHS |
| 110 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 380 444 474 495 499 511 523 529 534 558 |
| 561 574 575 579 580 586 589 600 611 611 |
| 617 617 620 620 621 626 656 656 670 677 |
| 686 695 708 710 713 720 725 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 329 389 421 474 485 505 508 529 552 560 |
| 560 562 565 579 582 586 593 607 607 620 |
| 621 626 627 632 640 656 666 674 677 687 |
| 688 690 695 698 698 701 702 711 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 93.9 83.7 73.5 55.1 32.7 16.3 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 98.0 94.0 82.0 64.0 44.0 24.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 98.0 94.0 90.0 84.0 66.0 48.0 22.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 50 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.3% 24.0% 22.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.324N P=0.270N P=0.350N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 579.9 602.1 600.5 |
|NATURAL DEATHS (C) | (15.0) (13.5) (15.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 594.3 632.5 628.8 |
|(STANDARD ERROR) | (17.6) (12.9) (13.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 342 493 522 552 585 606 613 613 618 619 |
| 632 636 639 655 669 680 697 698 708 717 |
| 723 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 225 271 280 382 390 408 476 514 533 533 |
| 562 578 578 582 585 612 637 651 677 689 |
| 689 692 708 712 719 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 271 294 308 314 373 374 377 387 466 479 |
| 522 536 537 545 557 588 620 626 639 665 |
| 666 669 672 689 702 715 718 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 98.0 94.0 90.0 72.0 56.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 98.0 94.0 88.0 86.0 80.0 70.0 64.0 48.0 |
| | |
| | |
|100 | 100.0 100.0 100.0 92.0 84.0 80.0 72.0 68.0 60.0 44.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 50 MG/KG 100 |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 48.0% 44.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.142 P=0.350 P=0.165 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 624.7 554.0 536.9 |
|NATURAL DEATHS (C) | (19.1) (29.0) (27.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.6 637.5 621.0 |
|(STANDARD ERROR) | (11.1) (19.4) (20.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
50 MG/KG = 2
100 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 31 2
| 31 21 2
| 1 3 1 2 2
| 1 1 3 322
90 + 11 3 22
| 2 2
| 11 3 222 3
| 1 1 1 2 32
80 + 11 22
| 1 1 322
P | 322
E | 1 11 33
R 70 + 22
C | 1 1 2
E | 2232
N | 1 1 3 3
T 60 + 22
| 1 1 33
S | 33
U | 1 1 33
R 50 + 22 3 3
V | 2 2 3
I | 1 1 2 23
V | 22 3
A 40 + 11 22
L | 11 2 2
| 11 32 2
| 1 1
30 + 11 3322
| 11 1 22
| 3332 2
| 113 3
20 +
| 1 1 1
|
|
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 29 obs hidden.
COCONUT OIL ACID DIETHANOLAMINE CONDENSATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
50 MG/KG = 2
100 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 2 3 1
| 2 2 3 1 1
96 + 22 3 3 1 1
| 2 3 3 2 1 1
| 3 3 22 1 1
| 2 2 1 1
P 88 + 2 2 11
E | 3 3 2 2
R | 3 3 2 2 11
C | 3 3
E 80 + 3 3 2 2 1 1
N | 3 3 2 2
T | 11
| 33 22 1 1
S 72 + 3 3 1 1
U | 3 2 2 1 1
R | 3 23 2 1 1
V | 332 2
I 64 + 3 32 2 1 1
V | 3 3 2 2 11
A | 33 11
L |
56 + 2 2 1
| 3 3
| 3 322
| 3 22
48 + 2
| 33
| 3
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.