TDMS Study 55312-04 Pathology Tables
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
2 YEAR CHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 68603-42-9
Lock Date: 09/06/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 11 11 15
Natural Death 4 3 9
Survivors
Terminal Sacrifice 35 35 26
Natural Death 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (48) (50)
Intestine Large, Rectum (50) (50) (50)
Intestine Small, Duodenum (50) (50) (50)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (49) (50) (50)
Carcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Liver (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatoblastoma 1 (2%) 2 (4%)
Hepatoblastoma, Multiple 1 (2%)
Hepatocellular Carcinoma 1 (2%) 17 (34%) 16 (32%)
Hepatocellular Carcinoma, Multiple 2 (4%) 4 (8%) 16 (32%)
Hepatocellular Adenoma 8 (16%) 5 (10%) 5 (10%)
Hepatocellular Adenoma, Multiple 24 (48%) 39 (78%) 38 (76%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Mesentery (12) (9) (8)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (11%)
Pancreas (50) (50) (50)
Hemangioma 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%)
Page 2
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Glandular (50) (50) (50)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (48) (50) (49)
Pars Distalis, Adenoma 5 (10%) 2 (4%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 2 (4%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (49) (47)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Ovary (50) (50) (50)
Cystadenoma 3 (6%) 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (2%)
Page 3
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Teratoma Benign 1 (2%)
Teratoma Malignant 1 (2%)
Uterus (50) (50) (50)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%) 2 (4%) 2 (4%)
Vagina (1)
Histiocytic Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Ovary 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (7) (3) (6)
Bronchial, Histiocytic Sarcoma 1 (33%)
Inguinal, Fibrosarcoma, Metastatic, Skin 1 (14%)
Lumbar, Histiocytic Sarcoma 1 (17%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (17%)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (14%)
Mediastinal, Hepatoblastoma, Metastatic,
Liver 1 (33%)
Mediastinal, Histiocytic Sarcoma 1 (33%) 1 (17%)
Pancreatic, Carcinoma, Metastatic, Thyroid
Gland 1 (14%)
Lymph Node, Mandibular (49) (47) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (48) (50) (49)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Spleen (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Thymus (47) (40) (41)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (3%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (50)
Carcinoma 1 (2%) 1 (2%)
Skin (50) (50) (50)
Melanoma Benign 1 (2%)
Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Melanoma Benign 1 (2%) 1 (2%)
Subcutaneous Tissue, Control, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 3 (6%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%) 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%) 9 (18%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mediastinum, Leiomyosarcoma, Metastatic,
Intestine Small, Jejunum 1 (2%)
Nose (50) (50) (49)
Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (1)
Carcinoma, Metastatic, Harderian Gland 1 (50%)
Harderian Gland (1) (2) (1)
Carcinoma 1 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%)
Lymphoma Malignant 13 (26%) 5 (10%) 7 (14%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 48 50
Total Primary Neoplasms 78 104 110
Total Animals with Benign Neoplasms 39 45 45
Total Benign Neoplasms 53 66 56
Total Animals with Malignant Neoplasms 23 30 41
Total Malignant Neoplasms 25 38 54
Total Animals with Metastatic Neoplasms 5 8 11
Total Metastatic Neoplasm 11 21 12
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 5 7 7
Natural Death 4 6 7
Survivors
Terminal Sacrifice 41 37 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50)
Intestine Large, Cecum (50) (50) (50)
Intestine Small, Duodenum (49) (50) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Intestine Small, Jejunum (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Liver (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%)
Hemangiosarcoma, Multiple 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%) 1 (2%)
Hepatoblastoma 1 (2%) 10 (20%)
Hepatoblastoma, Multiple 1 (2%)
Hepatocellular Carcinoma 7 (14%) 10 (20%) 12 (24%)
Hepatocellular Carcinoma, Multiple 5 (10%) 2 (4%) 8 (16%)
Hepatocellular Adenoma 11 (22%) 11 (22%) 4 (8%)
Hepatocellular Adenoma, Multiple 11 (22%) 24 (48%) 41 (82%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Mast Cell Tumor Malignant, Metastatic, Skin 1 (2%)
Mesentery (3) (3) (4)
Hepatoblastoma, Metastatic, Liver 1 (33%)
Hepatoblastoma, Metastatic, Pancreas 1 (25%)
Histiocytic Sarcoma 1 (33%) 1 (33%)
Oral Mucosa (1)
Gingival, Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (50) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatoblastoma, Metastatic, Pancreas 1 (2%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (50) (50) (50)
Hemangioma 1 (2%)
Page 8
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (50) (50) (50)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50)
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (45) (47) (49)
Pars Distalis, Adenoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ductus Deferens (1)
Epididymis (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Preputial Gland (49) (50) (50)
Prostate (50) (50) (50)
Seminal Vesicle (50) (49) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (2) (5) (1)
Lumbar, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (20%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (20%)
Mediastinal, Histiocytic Sarcoma 1 (20%)
Lymph Node, Mandibular (47) (45) (44)
Lymph Node, Mesenteric (46) (48) (47)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Spleen (50) (50) (50)
Hemangiosarcoma 3 (6%) 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Thymus (43) (44) (41)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Melanoma Malignant 1 (2%)
Skin, Site of Application, Mast Cell Tumor
Malignant 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (3)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Hepatoblastoma, Metastatic, Pancreas 1 (33%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 10 (20%) 7 (14%) 6 (12%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 3 (6%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 5 (10%) 2 (4%)
Hepatoblastoma, Metastatic, Liver 1 (2%) 3 (6%)
Hepatoblastoma, Metastatic, Pancreas 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 2 (4%) 4 (8%)
Histiocytic Sarcoma 2 (4%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Serosa, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (1)
Sarcoma 1 (100%)
Harderian Gland (3) (3) (6)
Adenoma 2 (67%)
Carcinoma 2 (67%) 3 (50%)
Bilateral, Carcinoma 1 (33%) 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mast Cell Tumor Malignant, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 7 (14%)
Renal Tubule, Carcinoma 2 (4%)
Urinary Bladder (50) (50) (50)
Page 11
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Lymphoma Malignant 2 (4%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 09/18/97
Route: SKIN APPLICATION Time: 08:19:06
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 100 200
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 45 50
Total Primary Neoplasms 65 80 113
Total Animals with Benign Neoplasms 26 39 47
Total Benign Neoplasms 38 49 65
Total Animals with Malignant Neoplasms 22 28 35
Total Malignant Neoplasms 27 31 48
Total Animals with Metastatic Neoplasms 9 3 12
Total Metastatic Neoplasm 17 9 16
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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