TDMS Study 55323-04 Pathology Tables
NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 2 YEAR CHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 120-40-1 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 2| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 6| 0| 9| 4| 7| 3| 7| 6| 7| 7| 2| 7| 6| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + + + + + + + + + + + M + A + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X X| Hepatocellular Adenoma, Multiple | X X X X X X X X | Lymphoma Malignant | X X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | Pars Distalis, Adenoma, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 2| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 6| 0| 9| 4| 7| 3| 7| 6| 7| 7| 2| 7| 6| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Granulosa-Theca Tumor Malignant | | Lymphoma Malignant | X | Bilateral, Granulosa Cell Tumor | | Benign | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa-Theca Tumor Malignant, | | Metastatic, Ovary | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node | + + + | Lumbar, Fibrous Histiocytoma | X | Lumbar, Lymphoma Malignant | X | Mediastinal, Fibrous Histiocytoma | X | Mediastinal, Lymphoma Malignant | X X | Popliteal, Fibrous Histiocytoma | X | Renal, Fibrous Histiocytoma | X | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X | Lymphoma Malignant | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 2| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 3| | 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 6| 0| 9| 4| 7| 3| 7| 6| 7| 7| 2| 7| 6| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X X X X X | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| | | 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X X | 2 | Hepatocellular Carcinoma | X X X X | 7 | Hepatocellular Carcinoma, Multiple | X | 3 | Hepatocellular Adenoma | X X X X | 11 | Hepatocellular Adenoma, Multiple | X X X X | 12 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Mesentery | + + + + + | 7 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + + + + + + M + + + M + + + + + + + + M + +| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + + + M + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| | | 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X X X | 9 | Pars Distalis, Adenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | X X X| 4 | Granulosa-Theca Tumor Malignant | X | 1 | Lymphoma Malignant | | 1 | Bilateral, Granulosa Cell Tumor | | | Benign | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa-Theca Tumor Malignant, | | | Metastatic, Ovary | X | 1 | Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node | + + | 5 | Lumbar, Fibrous Histiocytoma | | 1 | Lumbar, Lymphoma Malignant | | 1 | Mediastinal, Fibrous Histiocytoma | | 1 | Mediastinal, Lymphoma Malignant | | 2 | Popliteal, Fibrous Histiocytoma | | 1 | Renal, Fibrous Histiocytoma | | 1 | Renal, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + M + + + + + + + M + + + + + + + + +| 46 | Lymphoma Malignant | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Fibrous Histiocytoma | | 1 | Lymphoma Malignant | X X | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| | | 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemangiosarcoma | X | 2 | Lymphoma Malignant | X X X | 6 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X X | 7 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 3 | Lymphoma Malignant | X X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| | | 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| | 6| 6| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 4| 6| 1| 6| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X| Hepatocellular Adenoma | X X X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X | Lymphoma Malignant | X | __________________________________________________________________________| Mesentery | + + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M M + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + M + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Granulosa Cell Tumor Malignant | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| | 6| 6| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 4| 6| 1| 6| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granulosa Cell Tumor Benign | X X | Granulosa-Theca Tumor Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | X | Polyp Stromal | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Mediastinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | | Renal, Hemangiosarcoma | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Lymphoma Malignant | | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X X | Carcinoma, Metastatic, Harderian | | Gland | | Granular Cell Tumor Malignant, | | Metastatic, Ovary | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| | 6| 6| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 4| 6| 1| 6| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 5| 6| 3| 3| 3| | | 7| 7| 7| 1| 7| 6| 1| 6| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 7| 6| 8| 6| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X X X | 10 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X X X X X X X X| 18 | Hepatocellular Adenoma, Multiple | X X X X X | 15 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Mesentery | + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + M M + + + + + + + M + + + M + + +| 41 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 5| 6| 3| 3| 3| | | 7| 7| 7| 1| 7| 6| 1| 6| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 7| 6| 8| 6| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cystadenoma | X | 1 | Granulosa Cell Tumor Malignant | X | 1 | Granulosa Cell Tumor Benign | | 2 | Granulosa-Theca Tumor Malignant | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Deciduoma Benign | | 1 | Polyp Stromal | X | 1 | Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + +| 4 | Mediastinal, Lymphoma Malignant | | 1 | Pancreatic, Lymphoma Malignant | X X| 2 | Renal, Hemangiosarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrous Histiocytoma | X | 1 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + +| 47 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 5| 6| 3| 3| 3| | | 7| 7| 7| 1| 7| 6| 1| 6| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 7| 6| 8| 6| 6| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | X | 3 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Granular Cell Tumor Malignant, | | | Metastatic, Ovary | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X X X| 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7| DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2| | 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatoblastoma | | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X| Hepatocellular Adenoma, Multiple | X X X X X X | Histiocytic Sarcoma | X X| Lymphoma Malignant | X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant | X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + M + + + + + + + + + M + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7| DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2| | 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X X | Granulosa Cell Tumor Benign | | Histiocytic Sarcoma | X| Lymphoma Malignant | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + + + + +| Lumbar, Histiocytic Sarcoma | X| Lumbar, Lymphoma Malignant | X X X | Mediastinal, Lymphoma Malignant | X X X | Mediastinal, Pheochromocytoma | | Malignant, Metastatic, Adrenal | | Medulla | | Renal, Lymphoma Malignant | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X| Lymphoma Malignant | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X| Lymphoma Malignant | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7| DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2| | 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | | Subcutaneous Tissue, Skin, Site of | | Application, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | X X| Lymphoma Malignant | X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | Mediastinum, Hemangiosarcoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7| DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2| | 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | X X| Lymphoma Malignant | X X X X X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| | | 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X X X X X X | 14 | Hepatocellular Carcinoma, Multiple | X| 2 | Hepatocellular Adenoma | X X X X X X X | 14 | Hepatocellular Adenoma, Multiple | X X X X X X X X X | 15 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | | 2 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | __________________________________________________________________________|____________| Mesentery | + + | 4 | Lymphoma Malignant | | 1 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| | | 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + M + + + + M + + M + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X | 7 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | | 2 | Granulosa Cell Tumor Benign | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 1 | Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Lymph Node | + + | 7 | Lumbar, Histiocytic Sarcoma | | 1 | Lumbar, Lymphoma Malignant | | 3 | Mediastinal, Lymphoma Malignant | X | 4 | Mediastinal, Pheochromocytoma | | | Malignant, Metastatic, Adrenal | | | Medulla | X | 1 | Renal, Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| | | 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X| 5 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | Subcutaneous Tissue, Lymphoma | | | Malignant | X| 1 | Subcutaneous Tissue, Skin, Site of | | | Application, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | X X | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 2 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X| 4 | Pheochromocytoma Malignant, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| | | 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Metastatic, Adrenal Medulla | X | 1 | Mediastinum, Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X X X| 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | 6| 5| 6| 5| 6| 5| 3| 6| 6| 6| 0| 6| 5| 6| 4| 6| 5| 2| 5| 6| 6| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + M M + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Islets, | | Pancreatic | X | Hemangiosarcoma | X X X X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X| Lymphoma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + M + + M + + M + + M + + + M + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | 6| 5| 6| 5| 6| 5| 3| 6| 6| 6| 0| 6| 5| 6| 4| 6| 5| 2| 5| 6| 6| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | | Lumbar, Lymphoma Malignant | | Mediastinal, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinal, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Lymphoma Malignant | | __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + M + + +| Hemangioma | X | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | 6| 5| 6| 5| 6| 5| 3| 6| 6| 6| 0| 6| 5| 6| 4| 6| 5| 2| 5| 6| 6| 5| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Islets, | | Pancreatic | X | Hemangiosarcoma, Metastatic, Liver | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Lymphoma Malignant | | Bronchiole, Adenoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Ureter | | Lymphoma Malignant | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| | | 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Hemangiosarcoma | X X X | 7 | Hepatocellular Carcinoma | X X X X | 8 | Hepatocellular Carcinoma, Multiple | X | 3 | Hepatocellular Adenoma | X X X X X X X | 13 | Hepatocellular Adenoma, Multiple | X X X | 6 | Lymphoma Malignant | X X| 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X| 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| | | 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + M + + + M + + + + + + + + + + + + M +| 40 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Lymph Node | + + +| 3 | Lumbar, Lymphoma Malignant | X | 1 | Mediastinal, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | Mediastinal, Lymphoma Malignant | X | 1 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X X| 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + M + + + + + + + + + + M + M + + + + + + + +| 46 | Lymphoma Malignant | X X| 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | X X X| 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | Lymphoma Malignant | X X| 2 | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + M + M + + + + + + + + + + + +| 45 | Hemangioma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| | | 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X X X| 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M + M M M M M M M M M M + M M M + M M M M +| 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X X X | 6 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 2 | Carcinoma, Metastatic, Islets, | | | Pancreatic | | 1 | Hemangiosarcoma, Metastatic, Liver | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 3 | Lymphoma Malignant | X| 1 | Bronchiole, Adenoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| | DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| | | 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ureter | + | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X| 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X| 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 6| 9| 3| 0| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| | 6| 7| 6| 6| 6| 5| 6| 6| 5| 4| 5| 8| 5| 6| 6| 6| 5| 5| 5| 6| 5| 6| 6| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Carcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoid Tumor Malignant, | | Metastatic, Stomach, Glandular | | Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X X X X X| Hepatocellular Adenoma, Multiple | X | Hepatocholangiocarcinoma | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Acinus, Hepatocholangiocarcinoma, | | Metastatic, Liver | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoid Tumor Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M + + M M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 6| 9| 3| 0| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| | 6| 7| 6| 6| 6| 5| 6| 6| 5| 4| 5| 8| 5| 6| 6| 6| 5| 5| 5| 6| 5| 6| 6| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Mediastinal, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + M + + + + M + + + M + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + M + M + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X X X X X| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 6| 9| 3| 0| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3| | 6| 7| 6| 6| 6| 5| 6| 6| 5| 4| 5| 8| 5| 6| 6| 6| 5| 5| 5| 6| 5| 6| 6| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, Liver | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| | | 8| 6| 5| 5| 6| 6| 6| 5| 6| 6| 5| 2| 5| 5| 5| 5| 6| 6| 9| 8| 6| 7| 5| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoid Tumor Malignant, | | | Metastatic, Stomach, Glandular | X | 1 | Hemangiosarcoma | X | 2 | Hepatocellular Carcinoma | X X X X X | 8 | Hepatocellular Adenoma | X X X X X X X X X X X X X X | 22 | Hepatocellular Adenoma, Multiple | X X X | 4 | Hepatocholangiocarcinoma | X | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Acinus, Hepatocholangiocarcinoma, | | | Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoid Tumor Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 4 | Capsule, Adenoma | X X | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| | | 8| 6| 5| 5| 6| 6| 6| 5| 6| 6| 5| 2| 5| 5| 5| 5| 6| 6| 9| 8| 6| 7| 5| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + M + + + M + + + + + + + + + + + + + + M +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | Pars Distalis, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X X X| 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | | 2 | Mediastinal, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Lymphoma Malignant | | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M + + + + M + + + + + + +| 45 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| | | 8| 6| 5| 5| 6| 6| 6| 5| 6| 6| 5| 2| 5| 5| 5| 5| 6| 6| 9| 8| 6| 7| 5| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X X X | 8 | Hemangiosarcoma, Metastatic, Liver | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 4| 7| 4| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 4| 3| 9| 3| 6| 3| 3| 3| 3| | 6| 5| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 5| 1| 6| 5| 4| 6| 2| 5| 0| 6| 0| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoid Tumor Malignant, | | Metastatic, Stomach, Forestomach | | Carcinoma, Metastatic, Mammary Gland | | Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Carcinoid Tumor Malignant, | | Metastatic, Stomach, Glandular | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + M + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 4| 7| 4| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 4| 3| 9| 3| 6| 3| 3| 3| 3| | 6| 5| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 5| 1| 6| 5| 4| 6| 2| 5| 0| 6| 0| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Mediastinal, Carcinoma, Metastatic, | | Mammary Gland | | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Lymphoma Malignant | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| Carcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X X | Carcinoma, Metastatic, Mammary Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 4| 7| 4| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 4| 3| 9| 3| 6| 3| 3| 3| 3| | 6| 5| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 5| 1| 6| 5| 4| 6| 2| 5| 0| 6| 0| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | | Adenoma | | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 5| 3| 6| 6| 5| 6| 6| 9| 5| 6| 6| 5| 6| 5| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoid Tumor Malignant, | | | Metastatic, Stomach, Forestomach | X | 1 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Hemangiosarcoma | X X | 3 | Hepatocellular Carcinoma | X X X X | 11 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X X X X| 15 | Hepatocellular Adenoma, Multiple | X X X X X | 10 | __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Serosa, Carcinoid Tumor Malignant, | | | Metastatic, Stomach, Glandular | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + M + + + + M + + + + + + + + + + + M +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 5| 3| 6| 6| 5| 6| 6| 9| 5| 6| 6| 5| 6| 5| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + | 1 | Mediastinal, Carcinoma, Metastatic, | | | Mammary Gland | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| 1 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 55323-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97 Route: SKIN APPLICATION Time: 07:27:04 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 3| 5| 3| 6| 6| 5| 6| 6| 9| 5| 6| 6| 5| 6| 5| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X X X | 9 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X X| 6 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | __________________________________________________________________________|____________| Harderian Gland | + + + | 3 | Adenoma | X X X | 3 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------