TDMS Study 55323-04 Pathology Tables
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
2 YEAR CHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-40-1
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 2| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 6| 0| 9| 4| 7| 3| 7| 6| 7| 7| 2| 7| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + M + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X|
Infarct | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epithelium, Hyperkeratosis | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 3 |
Myocardium, Degeneration | 1 1 |
Ventricle, Inflammation, Chronic, | |
Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 3 1 1 2|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 2| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 6| 0| 9| 4| 7| 3| 7| 6| 7| 7| 2| 7| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Focal | 1 1 1 2 2 2 1 2 1 1 3 3 1 1 2 4 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 3 3 |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Endometrium, Hyperplasia, Cystic | 1 2 3 3 2 1 2 1 2 2 2 1 2 3 3 1 3 2 2 3|
Myometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 |
Hyperplasia, Lymphoid | 4 2 3 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Skin, Site of Application, | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 2| 3| 4| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 6| 0| 9| 4| 7| 3| 7| 6| 7| 7| 2| 7| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Nephropathy | 1 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| |
| 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | X X X X X X X X X | 15 |
Infarct | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
Fat, Necrosis | 2 2 2 3 2 | 7 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 1 4.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 1 2 | 3 2.0|
Epithelium, Hyperkeratosis | 4 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 3.0|
Myocardium, Degeneration | 1 1 1 | 5 1.0|
Ventricle, Inflammation, Chronic, | | |
Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| |
| 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + M + + + M + + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + M + + + + + + +| 47 |
Pars Distalis, Hyperplasia, Focal | 1 1 3 2 3 1 | 11 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Focal | 3 2 2 1 1 1 3 1 2 1 3 1 2 2 1 1 3 1 2| 38 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Cyst | 3 3 | 6 3.0|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 2 2 2 3 3 2 2 1 1 1 1 3 2 2 1| 38 1.9|
Myometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + M + + + + + + + M + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 4 2 | 7 2.4|
Hyperplasia, Lymphoid | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Parathyroid Gland | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 2| 1| 7| 3| 3| 6| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| |
| 7| 2| 6| 0| 9| 1| 6| 7| 2| 7| 7| 6| 6| 6| 8| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
0 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Skin, Site of Application, | | |
Hyperkeratosis | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
Fibrous Osteodystrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 4 1 | 2 2.5|
Mediastinum, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 1.0|
Nephropathy | 1 2 1 2 1 1 1 1 1 1 1| 19 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3|
| 6| 6| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 4| 6| 1| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Degeneration, Fatty, Focal | |
Eosinophilic Focus | X X X X X X X X|
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3|
| 6| 6| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 4| 6| 1| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | |
Follicle, Hyperplasia, Diffuse | |
Follicle, Hyperplasia, Focal | 3 2 1 3 1 4 2 2 1 2 3 3 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Endometrium, Hyperplasia, Cystic | 2 3 1 2 2 1 2 2 1 2 1 2 1 1 1 2 2 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 1 2 1 2 3 2 1 3 1 1 2 1 2 1 2 1 1 2 1|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 1 1 1 1 2 2 2 1 1 3 2 1 2 1 3 2 2 2 2|
Skin, Site of Application, | |
Hyperkeratosis | 2 1 1 2 2 3 3 2 1 2 1 1 2 1 3 2 2 1 1 1|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1|
Skin, Site of Application, | |
Parakeratosis | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3|
| 6| 6| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 4| 6| 1| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mixed Cell | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Axon, Nerve, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 5| 6| 3| 3| 3| |
| 7| 7| 7| 1| 7| 6| 1| 6| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 7| 6| 8| 6| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | | 2 |
Degeneration, Fatty, Focal | 1 1 | 2 1.0|
Eosinophilic Focus | X X X X X X X X X X X X | 20 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Fat, Necrosis | 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Acinus, Atrophy | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myocardium, Degeneration | 1 1 1 1| 10 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Hyperplasia, Focal | 1 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 1 1 | 9 1.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M + + + + + + + M + + + M + + +| 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 5| 6| 3| 3| 3| |
| 7| 7| 7| 1| 7| 6| 1| 6| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 7| 6| 8| 6| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis, Focal | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 1 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
C-Cell, Hyperplasia | 2 2 | 2 2.0|
Follicle, Hyperplasia, Diffuse | 4 | 1 4.0|
Follicle, Hyperplasia, Focal | 1 2 2 2 1 1 2 1 2 3 1 4 2 3 1 1 2 2 1| 34 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Cyst | 3 3 3 3 3 | 9 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 2 2 2 1 2 1 2 1 1 1 1 1 1 2 2 1 1 2 2 1| 46 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + +| 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 4 | 6 2.3|
Hyperplasia, Lymphoid | 1 3 1| 3 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 6| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 6| 3| 3| 5| 6| 3| 3| 3| |
| 7| 7| 7| 1| 7| 6| 1| 6| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 7| 6| 8| 6| 6| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 2 1 2 1 2 2 2 3 2 1 2 1 1 1 3 1 1 3 1 1 1| 42 1.6|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 1 1 2 2 2 3 2 1 1 2 1 2 1 2 2 2 2 1 2 1 1| 43 1.7|
Skin, Site of Application, | | |
Hyperkeratosis | 1 2 2 1 1 2 3 2 3 1 2 1 1 1 2 1 1 1 3 2 1| 41 1.7|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Skin, Site of Application, | | |
Parakeratosis | | 3 1.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Meninges, Infiltration Cellular, | | |
Mixed Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Axon, Nerve, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy | 1 1 1 2 1 1 1 1 1 1 1 1 2 | 30 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Artery, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2|
| 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X X X X X |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Atrium, Thrombosis | 4 |
Myocardium, Degeneration | |
Myocardium, Mineralization, Focal | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Necrosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M + + + + + + + + + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 3 2 1 1 |
Pars Distalis, Necrosis, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2|
| 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Hyperplasia, Focal | 2 1 2 1 3 2 3 1 3 2 4 1 3 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Granulomatous | |
Endometrium, Hyperplasia, Cystic | 2 1 1 1 3 2 1 2 1 1 1 2 2 2 3 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 2 3 2 1 3 1 1 3 3 1 3 2 3 2 3 3 2 2 3 2 2 2 2 3 2|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 2 2 2 2 2 1 2 3 2 2 2 2 2 1 2 2 2 2 1 2 2 |
Skin, Site of Application, | |
Hyperkeratosis | 2 2 1 1 4 1 1 2 1 3 1 2 1 2 3 1 1 3 2 3 1 2 2 3|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Skin, Site of Application, | |
Parakeratosis | 1 1 1 1 1 1 |
Skin, Site of Application, Ulcer | 1 1 1 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 4| 7| 6| 0| 5| 7| 7|
DAY ON TEST | 3| 3| 5| 2| 2| 3| 3| 5| 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 7| 3| 2| 8| 9| 3| 2|
| 7| 6| 7| 0| 0| 6| 6| 3| 3| 7| 0| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 4| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Granulomatous | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| |
| 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X X X X X X X X X X X X| 23 |
Hepatodiaphragmatic Nodule | | 1 |
Mixed Cell Focus | X | 2 |
Bile Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | 2 | 1 2.0|
Atrium, Thrombosis | | 1 4.0|
Myocardium, Degeneration | 1 1 1 1 1 | 5 1.0|
Myocardium, Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 2 1.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 6 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| |
| 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + M + + + + M + + M + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 1 1 1 1| 11 1.4|
Pars Distalis, Necrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Focal | 3 3 2 1 2 2 1 1 1 3 1 2 1 2 1 2 2 3 4 2| 36 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 | 8 3.0|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 | 2 3.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 1 2 2 2 1 1 1 2 2 1 1 1 1 1| 39 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 3 2 2 2 | 9 2.1|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 3 2 3 2 3 3 3 3 2 2 2 2 3 3 2 2 1 3 2 2 2 1 1 3 1| 50 2.2|
Sebaceous Gland, Skin, Site of | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 1| 3| 2| 3| 8| 3| 4| 1| 3| 3| 3| 1| 3| 3| 3| |
| 6| 6| 4| 7| 7| 3| 6| 7| 7| 6| 7| 7| 5| 9| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
200 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Application, Hyperplasia | 2 2 2 2 3 2 3 2 2 3 2 2 2 2 2 2 1 2 2 2 1 2 1| 45 2.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 1 1 1 2 2 2 2 2 1 3 1 3 3 3 1 1 4 1 2 2 2 2 1| 48 1.9|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 40 1.1|
Skin, Site of Application, | | |
Parakeratosis | 1 1 1 | 9 1.0|
Skin, Site of Application, Ulcer | | 3 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 1 | 1 1.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 1 2 1 1 1| 16 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 5| 6| 5| 3| 6| 6| 6| 0| 6| 5| 6| 4| 6| 5| 2| 5| 6| 6| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M M + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X X X X X |
Eosinophilic Focus | X X X X X X X|
Mixed Cell Focus | X |
Necrosis, Focal | |
Hepatocyte, Centrilobular, | |
Hypertrophy | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
Myocardium, Degeneration | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 |
Angiectasis | |
Hyperplasia, Focal | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 |
Hypertrophy | 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + M + + M + + + M + + + + M + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 5| 6| 5| 3| 6| 6| 6| 0| 6| 5| 6| 4| 6| 5| 2| 5| 6| 6| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Focal | 1 2 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 3 |
Hyperplasia, Lymphoid | 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 1 |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 2 |
Skin, Site of Application, | |
Hyperkeratosis | 2 1 |
Skin, Site of Application, | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 5| 6| 5| 3| 6| 6| 6| 0| 6| 5| 6| 4| 6| 5| 2| 5| 6| 6| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 1 1 1 1 2 1 1 1 |
Renal Tubule, Cyst | 3 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| |
| 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X X X X X X X X | 14 |
Eosinophilic Focus | X X X X X X X X | 15 |
Mixed Cell Focus | X | 2 |
Necrosis, Focal | 4 | 1 4.0|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 3.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | | 1 2.0|
Myocardium, Degeneration | | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 3.0|
Angiectasis | 3 | 1 3.0|
Hyperplasia, Focal | 4 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | 30 1.2|
Hypertrophy | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| |
| 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 1 3 1 2 1 1 1 2 1 2 1 2 2 1 1 | 27 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + M + + + + + + + + + + + + M +| 40 |
Cyst | 3| 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Focal | 1 1 1 2 2 2 1 | 18 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 3 3 | 23 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + +| 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + M + M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 | 6 2.0|
Hyperplasia, Lymphoid | | 3 1.7|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + M + M + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M M M M M M + M M M + M M M M +| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 1 | 4 1.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | | 1 2.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| |
DAY ON TEST | 3| 3| 4| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 4| |
| 6| 6| 1| 5| 6| 5| 2| 5| 5| 6| 5| 6| 5| 6| 6| 6| 5| 6| 6| 6| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1| 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.1|
Renal Tubule, Cyst | 2 | 2 2.5|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 6| 9| 3| 0| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3|
| 6| 7| 6| 6| 6| 5| 6| 6| 5| 4| 5| 8| 5| 6| 6| 6| 5| 5| 5| 6| 5| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Fibrosis, Focal | 1 |
Mixed Cell Focus | X X |
Bile Duct, Cyst | |
Hepatocyte, Centrilobular, | |
Hypertrophy | 3 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
Myocardium, Degeneration | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 1 1 1 1 1 4 1 2 1 1 1 2 1|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Focal | 1 3 1 4 1 1 4 2 1 1 2 1 1 3 2|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 6| 9| 3| 0| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3|
| 6| 7| 6| 6| 6| 5| 6| 6| 5| 4| 5| 8| 5| 6| 6| 6| 5| 5| 5| 6| 5| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 |
Hyperplasia | 1 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + M + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Epidermis, Skin, Site of Application,| |
Hyperplasia | 1 1 1 1 1 1 2 2 1 2 2 2 1 1 2 2 2 3 2 1 2|
Pinna, Fibrosis, Focal | |
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 2 1 1 2 2 2 2 1 2 2|
Skin, Site of Application, | |
Hyperkeratosis | 1 1 1 2 1 1 1 1 1 2 2 1 1 1 2 1 3 2 1 1|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Skin, Site of Application, | |
Parakeratosis | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 3| 6| 9| 3| 0| 3| 3| 3| 3| 3| 1| 0| 3| 3| 3|
| 6| 7| 6| 6| 6| 5| 6| 6| 5| 4| 5| 8| 5| 6| 6| 6| 5| 5| 5| 6| 5| 6| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
100 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic | 2 |
Renal Tubule, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| |
| 8| 6| 5| 5| 6| 6| 6| 5| 6| 6| 5| 2| 5| 5| 5| 5| 6| 6| 9| 8| 6| 7| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | X X X X X X | 7 |
Eosinophilic Focus | X X X X X X | 9 |
Fibrosis, Focal | | 1 1.0|
Mixed Cell Focus | X X X | 5 |
Bile Duct, Cyst | 3 3 | 2 3.0|
Hepatocyte, Centrilobular, | | |
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hyperkeratosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | | 1 3.0|
Myocardium, Degeneration | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 1 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 3 1 1 3 2 2 2 4 2 1| 28 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| |
| 8| 6| 5| 5| 6| 6| 6| 5| 6| 6| 5| 2| 5| 5| 5| 5| 6| 6| 9| 8| 6| 7| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + + M + + + + + + + + + + + + + + M +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Focal | 2 1 1 1 2 4 1 2 1 | 24 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 3 3 | 19 3.0|
Hyperplasia | | 1 1.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 | 7 2.4|
Hyperplasia, Lymphoid | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + M + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 1.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 2 1 1 1 2 2 2 2 2 1 1 1 2 1 1 2 2 2 2 1 2 2 2| 45 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| |
| 8| 6| 5| 5| 6| 6| 6| 5| 6| 6| 5| 2| 5| 5| 5| 5| 6| 6| 9| 8| 6| 7| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
100 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Pinna, Fibrosis, Focal | 3 | 1 3.0|
Sebaceous Gland, Skin, Site of | | |
Application, Hyperplasia | 2 2 1 1 1 2 2 2 2 2 1 2 2 2 2 2 1 2 1 2 3 1 1 1 2| 45 1.6|
Skin, Site of Application, | | |
Hyperkeratosis | 3 1 1 1 2 2 2 2 2 2 2 1 2 2 2 1 1 2 3 1 2 1 1 2 1| 45 1.5|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 | 13 1.0|
Skin, Site of Application, | | |
Parakeratosis | 2 | 1 2.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 1 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Artery, Inflammation, Chronic | | 1 2.0|
Renal Tubule, Cyst | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 4| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 4| 3| 9| 3| 6| 3| 3| 3| 3|
| 6| 5| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 5| 1| 6| 5| 4| 6| 2| 5| 0| 6| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X X |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 1 1 1 |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 1 1 1 1 2 1 1 3 1 1 1|
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 1 3 2 3 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 4| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 4| 3| 9| 3| 6| 3| 3| 3| 3|
| 6| 5| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 5| 1| 6| 5| 4| 6| 2| 5| 0| 6| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Focal | 3 1 1 3 1 1 3 3 1 1 1 1 1 2 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 |
Bilateral, Cyst | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Skin, Site of Application,| |
Hyperplasia | 3 2 3 2 2 2 1 2 1 2 2 2 2 2 3 1 3 1 1 1 1 1 1 2 2|
Sebaceous Gland, Skin, Site of | |
Application, Hyperplasia | 3 2 3 2 3 3 1 3 2 1 2 2 2 1 2 1 2 2 1 2 2 1 2 3|
Skin, Site of Application, | |
Hyperkeratosis | 3 2 3 1 2 2 2 1 1 2 2 2 2 2 1 3 1 1 2 1 1 1 2 2|
Skin, Site of Application, | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Skin, Site of Application, | |
Parakeratosis | 2 1 |
Skin, Site of Application, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 4| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 4| 3| 9| 3| 6| 3| 3| 3| 3|
| 6| 5| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 5| 1| 6| 5| 4| 6| 2| 5| 0| 6| 0| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Mediastinum, Infiltration Cellular, | |
Mast Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp, Inflammatory | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 3| 6| 6| 5| 6| 6| 9| 5| 6| 6| 5| 6| 5| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X X X X | 6 |
Eosinophilic Focus | X X X X X X X X | 15 |
Hepatodiaphragmatic Nodule | X X| 2 |
Mixed Cell Focus | X X | 2 |
Necrosis, Focal | 2 1 | 3 1.7|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Degeneration | 1 1 1 1 1 | 8 1.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 1 1 1 2 1 1 1 1 1 | 24 1.2|
Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 3| 6| 6| 5| 6| 6| 9| 5| 6| 6| 5| 6| 5| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 | 12 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + + M + + + + + + + + + + + M +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Focal | 1 2 1 3 3 2 1 2 1 3 1 1 3 4 1 2 2 2 2| 36 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 3 3 3 3 3 3 3 | 16 3.0|
Bilateral, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 1 2 3 2 2 2 1 2 2 1 3 2 2 3 2 2 2 1 2 1 1 1 1 3 3| 50 1.8|
Sebaceous Gland, Skin, Site of | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 55323-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC LAURIC ACID DIETHANOLAMINE CONDENSATE Date: 07/30/97
Route: SKIN APPLICATION Time: 07:35:07
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 3| 4| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 3| 6| 6| 5| 6| 6| 9| 5| 6| 6| 5| 6| 5| 6| 6| 6| 5| 5| 5| 6| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Application, Hyperplasia | 1 3 3 2 2 2 2 3 1 2 2 2 2 2 2 3 2 3 1 2 2 1 2 3| 48 2.0|
Skin, Site of Application, | | |
Hyperkeratosis | 3 1 2 2 1 2 2 2 1 1 2 1 1 3 2 1 2 2 1 1 2 2 1 2 3| 49 1.7|
Skin, Site of Application, | | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Skin, Site of Application, | | |
Parakeratosis | 2 2 1| 5 1.6|
Skin, Site of Application, Ulcer | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 | 2 1.0|
Mediastinum, Infiltration Cellular, | | |
Mast Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp, Inflammatory | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1| 33 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
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---------- END OF REPORT ----------
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