TDMS Study 56111-03 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus TRANS-CINNAMALDEHYDE DATE: 07/02/01
EXPERIMENT: 56111 TEST: 03 TIME: 09:43:58
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C56111B
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS LABORATORY TRANS-CINNAMALDEHYDE DATE: 07/02/01
EXPERIMENT: 56111 TEST: 03 TIME: 9:52:42
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: 56111B
CONT: N01-ES-55384 CAS: 14371-10-9
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==================================================================================================================================
UNTREATDCONTROL VEHICLE CONTROL .312% .625%
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 17.2 97.7 17.3 97.3 1.01 0 16.6 97.8 0.97 531 15.5 97.6 0.90 994
2 17.3 133.8 17.6 134.1 1.02 0 16.9 132.2 0.98 398 16.2 128.9 0.94 785
6 19.7 252.7 20.0 255.0 1.02 0 19.7 251.7 1.00 244 19.5 244.1 0.99 499
10 16.7 306.7 16.2 307.9 0.97 0 16.4 303.8 0.98 169 16.4 293.9 0.98 348
14 17.4 343.3 17.7 349.9 1.02 0 17.2 341.8 0.99 157 16.5 329.0 0.95 314
18 17.0 374.2 17.0 377.6 1.00 0 15.9 368.1 0.94 135 16.0 358.0 0.94 279
22 18.2 393.1 18.3 396.7 1.01 0 17.6 381.7 0.97 144 17.6 375.1 0.97 293
26 18.9 403.5 20.2 409.9 1.07 0 19.3 396.5 1.02 152 18.0 387.4 0.95 291
30 19.6 420.5 19.1 423.9 0.97 0 18.5 413.2 0.94 140 19.4 403.9 0.99 300
34 19.2 439.2 19.3 443.8 1.01 0 18.4 430.0 0.96 134 18.8 419.6 0.98 280
38 19.4 444.5 19.1 448.1 0.98 0 19.2 438.0 0.99 137 18.3 428.5 0.94 267
42 18.1 458.4 18.1 463.1 1.00 0 17.4 449.4 0.96 121 18.3 439.7 1.01 260
46 18.5 465.6 18.7 468.4 1.01 0 18.2 455.9 0.98 125 18.5 446.4 1.00 259
50 18.4 467.5 19.8 474.8 1.08 0 18.7 461.6 1.02 126 18.4 452.5 1.00 254
54 18.0 473.8 17.9 484.0 0.99 0 17.3 467.8 0.96 115 17.8 458.2 0.99 243
58 16.8 477.9 17.1 481.5 1.02 0 15.8 468.3 0.94 105 16.2 463.3 0.96 219
62 16.0 472.2 16.9 476.1 1.06 0 16.4 465.5 1.03 110 16.6 457.4 1.04 226
66 18.0 479.2 18.5 488.7 1.03 0 18.3 471.3 1.02 121 17.6 461.3 0.98 238
70 17.1 478.1 17.0 480.2 0.99 0 16.9 471.8 0.99 111 17.2 463.7 1.01 232
74 17.9 482.7 17.8 485.0 0.99 0 18.4 475.2 1.03 121 17.9 468.0 1.00 240
78 18.1 482.4 18.2 486.3 1.01 0 18.4 476.3 1.02 121 18.0 468.7 0.99 240
82 17.7 485.1 17.3 490.9 0.98 0 16.4 475.6 0.93 108 17.0 469.5 0.96 226
86 17.8 478.0 16.9 486.8 0.95 0 16.6 474.4 0.93 109 17.3 466.6 0.97 231
90 17.4 480.0 17.7 492.1 1.02 0 17.0 474.6 0.98 112 16.6 460.2 0.95 225
94 17.3 476.7 16.6 484.6 0.96 0 16.3 475.4 0.94 107 16.3 461.4 0.94 221
98 15.8 479.8 17.0 488.3 1.08 0 14.8 465.6 0.94 99 14.9 451.2 0.94 206
102 16.0 469.8 17.5 486.9 1.09 0 16.2 467.3 1.01 108 15.0 443.0 0.94 211
1 TO 13 WEEKS
----------------
MEAN 17.7 197.7 17.8 198.6 1.00 0 17.4 196.4 0.98 335 16.9 191.1 0.95 657
SD(D) 1.3 1.6 0.02 0 1.5 0.01 161 1.8 0.04 289
CV(E) 7.5 8.9 2.2 8.7 1.5 48.2 10.5 4.4 44.0
14 TO 52 WEEKS
----------------
MEAN 18.5 421.0 18.7 425.6 1.01 0 18.0 413.6 0.98 137 18.0 404.0 0.97 280
SD(D) 0.8 1.0 0.03 0 1.0 0.03 12 1.0 0.03 20
CV(E) 4.5 5.2 3.3 5.6 2.9 8.5 5.7 2.7 7.1
> 52 WEEKS
----------------
MEAN 17.2 478.1 17.4 485.5 1.01 0 16.8 471.5 0.98 111 16.8 461.0 0.98 228
SD(D) 0.8 0.6 0.04 0 1.1 0.04 7 1.0 0.03 11
CV(E) 4.8 3.3 4.2 6.3 4.0 5.9 6.0 3.0 4.9
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==========================================
1.25%
---------------------------------
DOSE/
GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C)
==========================================
1 12.6 97.9 0.73 1607
2 15.4 121.6 0.89 1585
6 18.7 236.6 0.95 989
10 16.3 283.7 0.98 718
14 16.9 320.1 0.97 661
18 15.0 345.2 0.88 544
22 17.1 360.5 0.94 592
26 18.2 372.8 0.96 610
30 17.4 388.4 0.89 561
34 18.5 403.6 0.96 572
38 18.4 410.6 0.95 560
42 16.3 420.5 0.90 485
46 18.0 426.7 0.97 528
50 17.7 433.2 0.96 510
54 17.1 437.9 0.95 487
58 15.6 441.2 0.93 441
62 16.0 438.2 1.00 457
66 17.3 444.8 0.96 486
70 15.6 442.2 0.91 440
74 17.9 444.6 1.00 504
78 17.4 444.3 0.96 489
82 16.1 448.2 0.91 450
86 16.6 445.0 0.93 466
90 15.9 440.4 0.91 450
94 14.8 443.5 0.86 417
98 15.6 439.2 0.99 444
102 15.7 434.8 0.98 451
1 TO 13 WEEKS
----------------
MEAN 15.8 184.9 0.89 1225
SD(D) 2.5 0.11 443
CV(E) 16.1 12.3 36.2
14 TO 52 WEEKS
----------------
MEAN 17.4 388.2 0.94 562
SD(D) 1.1 0.04 51
CV(E) 6.2 3.8 9.0
> 52 WEEKS
----------------
MEAN 16.3 441.9 0.95 460
SD(D) 0.9 0.04 25
CV(E) 5.6 4.5 5.4
==========================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==================================================================================================================================
UNTREATDCONTROL VEHICLE CONTROL .312% .625%
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
1 12.9 92.4 12.9 94.2 1.00 0 12.8 91.2 0.99 437 12.5 92.8 0.97 843
2 12.4 113.3 12.3 113.4 0.99 0 12.4 113.1 1.00 343 12.5 112.5 1.01 694
6 12.1 162.0 12.4 163.1 1.02 0 12.2 159.5 1.01 238 11.8 159.7 0.98 463
10 10.8 180.8 10.6 181.5 0.98 0 10.7 178.6 0.99 187 9.8 175.2 0.91 350
14 10.3 191.4 10.3 191.1 1.00 0 11.2 193.6 1.09 181 10.6 187.1 1.03 354
18 10.9 200.5 10.9 200.5 1.00 0 10.8 200.6 0.99 167 10.7 198.1 0.98 336
22 11.0 208.5 11.5 212.3 1.05 0 11.8 211.5 1.07 174 10.6 204.3 0.96 325
26 11.1 210.6 11.5 214.0 1.04 0 12.0 213.9 1.08 175 11.3 207.1 1.02 340
30 12.0 220.2 12.9 220.6 1.08 0 11.9 221.5 0.99 168 11.8 215.0 0.98 342
34 12.2 230.1 12.3 233.5 1.01 0 12.5 231.7 1.02 169 11.5 224.7 0.94 320
38 11.7 236.3 12.0 237.6 1.03 0 12.2 238.6 1.04 160 11.8 229.2 1.01 322
42 11.4 242.6 11.7 246.8 1.03 0 11.7 246.4 1.03 148 11.6 239.3 1.02 302
46 12.1 250.4 12.4 255.4 1.02 0 12.6 254.6 1.04 155 11.9 245.6 0.98 302
50 12.7 261.1 11.4 262.2 0.90 0 12.5 264.3 0.98 148 12.1 253.1 0.95 299
54 12.3 271.0 12.2 274.1 0.99 0 11.8 273.7 0.96 134 12.1 263.7 0.98 287
58 11.6 278.2 12.1 282.9 1.04 0 11.4 279.6 0.98 128 12.1 269.3 1.04 280
62 11.6 286.0 11.4 288.8 0.98 0 12.0 288.0 1.03 129 11.3 276.3 0.97 255
66 11.8 291.7 11.4 294.0 0.97 0 12.4 293.4 1.05 132 11.8 282.5 1.00 262
70 11.9 296.7 12.0 299.1 1.01 0 12.7 298.6 1.07 132 12.6 288.3 1.06 273
74 12.6 308.4 13.1 309.9 1.04 0 13.3 309.6 1.06 134 12.5 298.2 0.99 262
78 12.6 309.2 12.7 315.7 1.01 0 12.6 311.7 1.00 126 12.3 298.2 0.98 258
82 12.7 314.7 13.1 319.7 1.03 0 13.0 317.6 1.02 127 13.4 307.5 1.06 271
86 13.2 321.4 13.0 324.3 0.98 0 13.4 321.3 1.02 130 12.8 313.4 0.97 256
90 13.0 327.6 12.4 330.6 0.95 0 12.5 325.3 0.96 120 12.2 315.1 0.94 241
94 12.4 325.1 13.2 336.4 1.06 0 12.8 326.8 1.03 122 13.2 325.7 1.06 253
98 12.9 330.8 12.3 338.1 0.95 0 12.6 328.7 0.98 120 11.9 329.5 0.92 226
102 11.9 328.6 12.7 344.4 1.07 0 13.4 332.2 1.13 126 13.6 337.3 1.14 251
1 TO 13 WEEKS
----------------
MEAN 12.1 137.1 12.0 138.0 1.00 0 12.0 135.6 1.00 301 11.7 135.1 0.96 588
SD(D) 0.9 1.0 0.02 0 0.9 0.01 112 1.3 0.04 223
CV(E) 7.5 8.1 1.8 7.7 0.8 37.1 11.0 4.4 37.9
14 TO 52 WEEKS
----------------
MEAN 11.5 225.2 11.7 227.4 1.01 0 11.9 227.7 1.03 164 11.4 220.3 0.99 324
SD(D) 0.7 0.7 0.05 0 0.6 0.04 11 0.6 0.03 19
CV(E) 6.3 6.4 4.6 5.0 3.7 6.9 5.0 3.0 5.8
> 52 WEEKS
----------------
MEAN 12.4 306.9 12.4 312.2 1.01 0 12.6 308.2 1.02 128 12.4 300.4 1.01 260
SD(D) 0.5 0.6 0.04 0 0.6 0.05 5 0.7 0.06 16
CV(E) 4.3 4.9 3.9 4.8 4.6 3.9 5.3 6.0 6.2
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==========================================
1.25%
---------------------------------
DOSE/
GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C)
==========================================
1 10.8 93.9 0.84 1433
2 12.1 110.0 0.98 1373
6 11.5 155.9 0.95 924
10 10.2 173.4 0.94 738
14 10.5 184.8 1.02 712
18 10.4 190.6 0.95 682
22 10.6 199.5 0.96 663
26 10.8 201.0 0.97 670
30 11.5 207.1 0.96 695
34 11.4 217.6 0.93 655
38 11.4 221.5 0.97 642
42 10.8 227.7 0.95 595
46 11.3 236.4 0.93 597
50 12.0 242.6 0.94 619
54 11.8 252.1 0.96 583
58 11.3 258.3 0.97 545
62 11.3 265.8 0.97 529
66 11.6 270.8 0.98 538
70 12.0 277.2 1.01 541
74 12.2 285.7 0.97 535
78 11.4 285.6 0.90 500
82 12.2 290.6 0.96 525
86 12.1 295.4 0.92 512
90 12.0 300.6 0.92 500
94 12.5 309.7 1.01 504
98 11.4 309.6 0.88 459
102 11.8 309.3 0.99 475
1 TO 13 WEEKS
----------------
MEAN 11.2 133.3 0.93 1117
SD(D) 0.8 0.06 340
CV(E) 7.3 6.6 30.4
14 TO 52 WEEKS
----------------
MEAN 11.1 212.9 0.96 653
SD(D) 0.5 0.03 40
CV(E) 4.7 2.6 6.1
> 52 WEEKS
----------------
MEAN 11.8 285.4 0.96 519
SD(D) 0.4 0.04 32
CV(E) 3.4 4.1 6.2
==========================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==================================================================================================================================
UNTREATDCONTROL VEHICLE CONTROL .312% .625% 1.25%
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 97.7 50 97.3 50 97.8 50 97.6 50 97.9 50
1 17.2 3302 97.7 50 17.3 3306 97.3 50 16.6 3309 97.8 50 15.5 3322 97.6 50 12.6 3323 97.9 50
2 17.3 4840 133.8 50 17.6 4864 134.1 50 16.9 4929 132.2 50 16.2 4869 128.9 50 15.4 4907 121.6 50
5 18.6 3767 18.4 3778 18.2 3775 18.1 3773 17.8 3771
6 19.7 4645 252.7 50 20.0 4617 255.0 50 19.7 4643 251.7 50 19.5 4667 244.1 50 18.7 4654 236.6 50
9 17.5 3295 17.7 3506 17.8 3566 17.2 3561 17.0 3632
10 16.7 4935 306.7 50 16.2 4911 307.9 50 16.4 4591 303.8 50 16.4 4872 293.9 50 16.3 4837 283.7 50
13 17.1 3618 17.6 3579 17.0 3650 16.9 3523 16.7 3488
14 17.4 4839 343.3 50 17.7 4876 349.9 50 17.2 4912 341.8 50 16.5 4950 329.0 50 16.9 4986 320.1 50
17 18.1 3567 17.9 3392 16.6 3580 16.2 3650 15.6 3650
18 17.0 4928 374.2 50 17.0 4939 377.6 50 15.9 4944 368.1 50 16.0 4957 358.0 50 15.0 4962 345.2 50
21 16.6 3779 16.6 3777 16.4 3543 16.5 3704 16.2 3782
22 18.2 4634 393.1 50 18.3 4650 396.7 50 17.6 4395 381.7 50 17.6 4620 375.1 49 17.1 4729 360.5 50
25 18.4 3468 19.1 3615 19.0 3558 18.0 3545 18.3 3629
26 18.9 4771 403.5 50 20.2 4779 409.9 50 19.3 4698 396.5 49 18.0 4719 387.4 49 18.2 4811 372.8 50
29 18.9 3580 18.6 3332 18.4 3222 18.8 3009 17.6 3130
30 19.6 4821 420.5 50 19.1 4869 423.9 50 18.5 4761 413.2 49 19.4 4669 403.9 48 17.4 4911 388.4 50
33 18.1 3750 18.4 3740 17.9 3700 18.1 3636 17.8 3773
34 19.2 4644 439.2 50 19.3 4662 443.8 50 18.4 4310 430.0 49 18.8 4518 419.6 48 18.5 4725 403.6 50
37 18.8 3626 18.9 3412 18.2 3561 17.7 3501 17.8 3662
38 19.4 4275 444.5 50 19.1 4611 448.1 50 19.2 4473 438.0 49 18.3 4361 428.5 48 18.4 4583 410.6 50
41 18.8 3471 18.8 3617 18.1 3545 19.0 3509 17.5 3637
42 18.1 4806 458.4 50 18.1 4822 463.1 50 17.4 4741 449.4 49 18.3 4621 439.7 48 16.3 4859 420.5 50
45 18.7 3700 18.9 3694 18.9 3626 18.6 3546 17.9 3700
46 18.5 4795 465.6 50 18.7 4850 468.4 50 18.2 4712 455.9 49 18.5 4581 446.4 48 18.0 4813 426.7 50
49 18.6 3685 20.1 3655 19.6 3467 19.4 3386 18.9 3534
50 18.4 4796 467.5 50 19.8 4774 474.8 50 18.7 4719 461.6 49 18.4 4641 452.5 48 17.7 4819 433.2 50
53 18.5 3360 18.6 3506 18.3 3436 18.4 3368 18.2 3511
54 18.0 4848 473.8 50 17.9 4869 484.0 50 17.3 4846 467.8 49 17.8 4770 458.2 48 17.1 4985 437.9 50
57 16.7 3660 16.4 3666 16.0 3578 16.5 3487 15.8 3631
58 16.8 4776 477.9 50 17.1 4480 481.5 50 15.8 4690 468.3 49 16.2 4629 463.3 48 15.6 4804 441.2 50
61 16.1 3514 16.6 3550 16.2 3415 16.4 3438 16.1 3578
62 16.0 4879 472.2 50 16.9 4570 476.1 50 16.4 4645 465.5 48 16.6 4335 457.4 48 16.0 4836 438.2 50
65 18.1 3595 18.7 3474 19.4 3445 18.7 3402 18.3 3575
66 18.0 4785 479.2 50 18.5 4716 488.7 49 18.3 4654 471.3 48 17.6 4388 461.3 48 17.3 4897 444.8 50
69 16.7 3630 17.0 3543 16.8 3521 17.0 3516 16.1 3684
70 17.1 4741 478.1 50 17.0 4411 480.2 49 16.9 4548 471.8 48 17.2 4577 463.7 48 15.6 4494 442.2 50
73 18.6 3289 18.3 3119 18.0 3444 17.7 3202 17.1 3577
74 17.9 4564 482.7 49 17.8 4284 485.0 46 18.4 4466 475.2 48 17.9 4325 468.0 46 17.9 4619 444.6 49
77 17.1 3456 17.5 3312 17.2 3456 16.6 3146 16.1 3528
78 18.1 4418 482.4 48 18.2 4255 486.3 46 18.4 4461 476.3 48 18.0 4121 468.7 44 17.4 4635 444.3 49
81 17.6 3576 17.3 3409 17.1 3591 17.3 3150 16.2 3566
82 17.7 4506 485.1 48 17.3 4016 490.9 45 16.4 4576 475.6 48 17.0 4145 469.5 43 16.1 4753 448.2 49
85 16.7 3239 17.1 2980 16.7 3372 16.5 2900 17.2 3247
86 17.8 3931 478.0 46 16.9 4050 486.8 42 16.6 4489 474.4 46 17.3 3731 466.6 40 16.6 4805 445.0 49
89 17.0 3089 18.1 2739 17.3 3235 16.2 2688 16.8 3450
90 17.4 4095 480.0 43 17.7 3346 492.1 37 17.0 4373 474.6 45 16.6 2736 460.2 35 15.9 4815 440.4 49
93 17.7 2849 16.3 2514 16.5 3123 16.6 2330 16.3 3365
94 17.3 4044 476.7 42 16.6 3122 484.6 35 16.3 4180 475.4 43 16.3 3132 461.4 33 14.8 4726 443.5 48
97 16.5 2761 17.5 2303 15.8 2929 15.1 2204 16.4 3166
==================================================================================================================================
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==================================================================================================================================
UNTREATDCONTROL VEHICLE CONTROL .312% .625% 1.25%
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
98 15.8 3821 479.8 39 17.0 3218 488.3 33 14.8 4121 465.6 42 14.9 3014 451.2 30 15.6 4483 439.2 45
101 14.9 2514 16.6 2442 15.8 2813 14.9 2075 16.6 3199
102 16.0 2829 469.8 36 17.5 2861 486.9 32 16.2 3633 467.3 38 15.0 2494 443.0 28 15.7 4128 434.8 43
MEAN BODY WGT FOR WEEKS
1 TO 13 197.7 198.6 196.4 191.1 184.9
14 TO 52 421.0 425.6 413.6 404.0 388.2
> 52 478.1 485.5 471.5 461.0 441.9
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==================================================================================================================================
UNTREATDCONTROL VEHICLE CONTROL .312% .625% 1.25%
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 92.4 50 94.2 50 91.2 50 92.8 50 93.9 50
1 12.9 3441 92.4 50 12.9 3450 94.2 50 12.8 3445 91.2 50 12.5 3450 92.8 50 10.8 3442 93.9 50
2 12.4 4855 113.3 50 12.3 4848 113.4 50 12.4 4870 113.1 50 12.5 4897 112.5 50 12.1 4916 110.0 50
5 12.5 3505 12.5 3501 12.1 3150 12.2 3510 11.9 3498
6 12.1 4795 162.0 50 12.4 4776 163.1 50 12.2 4807 159.5 50 11.8 4877 159.7 50 11.5 4839 155.9 50
9 11.8 3470 11.8 3471 11.9 3480 10.6 3391 11.0 3480
10 10.8 4849 180.8 50 10.6 4923 181.5 50 10.7 4965 178.6 50 9.8 4850 175.2 49 10.2 4915 173.4 50
13 10.1 3601 10.1 3249 11.1 3529 10.2 3519 9.9 3611
14 10.3 4784 191.4 50 10.3 4737 191.1 50 11.2 4687 193.6 49 10.6 4718 187.1 49 10.5 4721 184.8 50
17 10.4 3616 10.4 3635 10.1 3591 10.5 3592 9.5 3670
18 10.9 4778 200.5 50 10.9 4792 200.5 50 10.8 4704 200.6 49 10.7 4714 198.1 49 10.4 4822 190.6 50
21 11.9 3456 12.1 3456 12.1 3391 11.2 3415 11.0 3506
22 11.0 4750 208.5 50 11.5 4762 212.3 50 11.8 4677 211.5 49 10.6 4664 204.3 49 10.6 4801 199.5 50
25 11.6 3585 11.9 3580 12.0 3504 11.1 3508 10.9 3580
26 11.1 4830 210.6 50 11.5 4841 214.0 50 12.0 4750 213.9 49 11.3 4760 207.1 49 10.8 4282 201.0 49
29 11.7 3641 10.4 3279 11.5 3572 11.5 3503 10.9 3577
30 12.0 4803 220.2 49 12.9 4835 220.6 50 11.9 4745 221.5 49 11.8 4658 215.0 48 11.5 4760 207.1 49
33 10.5 3783 11.4 3864 11.4 3792 10.6 3716 10.1 3793
34 12.2 4516 230.1 49 12.3 4626 233.5 50 12.5 4548 231.7 49 11.5 4471 224.7 48 11.4 4582 217.6 49
37 12.4 3165 11.6 3600 12.3 3539 11.9 3476 11.3 3185
38 11.7 4499 236.3 49 12.0 4607 237.6 50 12.2 4579 238.6 49 11.8 4457 229.2 48 11.4 4523 221.5 49
41 11.8 3469 12.1 3540 12.0 3498 12.0 3411 11.7 3480
42 11.4 4736 242.6 49 11.7 4847 246.8 50 11.7 4765 246.4 49 11.6 4679 239.3 48 10.8 4787 227.7 49
45 12.4 3533 12.6 3605 13.4 3528 11.9 3451 11.5 3518
46 12.1 4818 250.4 49 12.4 4852 255.4 50 12.6 4842 254.6 49 11.9 4633 245.6 48 11.3 4721 236.4 49
49 12.7 3691 12.0 3756 12.6 3646 12.0 3557 11.9 3620
50 12.7 4715 261.1 49 11.4 4821 262.2 50 12.5 4691 264.3 49 12.1 4586 253.1 48 12.0 4674 242.6 49
53 12.4 3427 12.5 3501 12.4 3434 12.2 3370 12.2 3440
54 12.3 4669 271.0 49 12.2 4785 274.1 50 11.8 4708 273.7 49 12.1 4620 263.7 48 11.8 4729 252.1 49
57 12.3 3416 11.9 3500 11.6 3419 12.7 3360 11.4 3425
58 11.6 4676 278.2 49 12.1 4777 282.9 50 11.4 4762 279.6 49 12.1 4212 269.3 48 11.3 4728 258.3 49
61 11.6 3582 11.4 3657 11.1 3556 10.9 3457 11.6 3514
62 11.6 4657 286.0 49 11.4 4711 288.8 50 12.0 4693 288.0 49 11.3 4587 276.3 48 11.3 4671 265.8 49
65 11.7 3529 11.7 3602 11.7 3536 11.5 3464 11.7 3538
66 11.8 4742 291.7 49 11.4 4849 294.0 50 12.4 4677 293.4 49 11.8 4680 282.5 48 11.6 4716 270.8 49
69 13.3 3409 13.2 3471 13.5 3144 13.6 3190 13.0 3410
70 11.9 4844 296.7 49 12.0 4949 299.1 50 12.7 4858 298.6 49 12.6 4480 288.3 46 12.0 4792 277.2 49
73 12.8 3435 13.2 3547 13.3 3528 12.1 3242 12.1 3511
74 12.6 4588 308.4 49 13.1 4698 309.9 50 13.3 4574 309.6 49 12.5 4209 298.2 45 12.2 4595 285.7 49
77 12.2 3601 12.5 3522 12.8 3602 12.5 3307 11.6 3606
78 12.6 4595 309.2 49 12.7 4522 315.7 48 12.6 4678 311.7 49 12.3 4311 298.2 45 11.4 4614 285.6 48
81 13.6 3515 13.4 3495 13.7 3465 14.3 3180 12.7 3471
82 12.7 4552 314.7 48 13.1 4589 319.7 48 13.0 4621 317.6 48 13.4 4250 307.5 44 12.2 4556 290.6 47
85 13.3 3373 13.2 3442 13.4 3438 13.3 3141 12.3 3249
86 13.2 4487 321.4 47 13.0 4603 324.3 48 13.4 4622 321.3 48 12.8 4252 313.4 44 12.1 4365 295.4 45
89 12.7 3256 12.2 3327 12.3 3265 12.9 2977 12.9 3134
90 13.0 4480 327.6 45 12.4 3979 330.6 46 12.5 4366 325.3 45 12.2 4108 315.1 42 12.0 4256 300.6 44
93 12.4 3170 13.6 3180 13.0 3129 13.5 2947 13.8 2933
94 12.4 4327 325.1 44 13.2 4417 336.4 45 12.8 4285 326.8 44 13.2 3966 325.7 41 12.5 4002 309.7 41
97 12.1 3073 11.5 3225 12.3 3041 12.0 2729 11.1 2945
==================================================================================================================================
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE
==================================================================================================================================
UNTREATDCONTROL VEHICLE CONTROL .312% .625% 1.25%
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
98 12.9 3723 330.8 40 12.3 3969 338.1 42 12.6 3702 328.7 39 11.9 3687 329.5 39 11.4 3636 309.6 39
101 12.2 2699 12.8 2709 13.3 2542 14.0 2707 11.8 2614
102 11.9 3575 328.6 37 12.7 3391 344.4 37 13.4 3399 332.2 35 13.6 3606 337.3 37 11.8 3521 309.3 36
MEAN BODY WGT FOR WEEKS
1 TO 13 137.1 138.0 135.6 135.1 133.3
14 TO 52 225.2 227.4 227.7 220.3 212.9
> 52 306.9 312.2 308.2 300.4 285.4
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.