TDMS Study 56111-03 Pathology Tables
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 14371-10-9
Lock Date: 06/01/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 11 10 13 10 10
Natural Death 5 4 4 4 7
Survivors
Terminal Sacrifice 33 36 33 35 33
Natural Death 1
Missing 1
Animals Examined Microscopically 50 50 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49) (50)
Inflammation, Chronic 1 (2%)
Intestine Large, Colon (50) (50) (50) (49) (50)
Parasite Metazoan 1 (2%) 5 (10%) 4 (8%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (49) (50)
Parasite Metazoan 4 (8%) 1 (2%) 3 (6%) 1 (2%)
Intestine Large, Cecum (50) (49) (50) (49) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (49) (50)
Mineralization 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (49) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Ileum (50) (50) (50) (49) (50)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (49) (50)
Angiectasis 1 (2%)
Basophilic Focus 42 (84%) 44 (88%) 42 (84%) 43 (88%) 44 (88%)
Clear Cell Focus 1 (2%) 2 (4%) 2 (4%)
Eosinophilic Focus 1 (2%) 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%) 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 5 (10%) 12 (24%) 9 (18%) 7 (14%)
Infarct 1 (2%)
Inflammation, Chronic Active 44 (88%) 41 (82%) 42 (84%) 42 (86%) 43 (86%)
Mixed Cell Focus 26 (52%) 25 (50%) 24 (48%) 27 (55%) 20 (40%)
Necrosis 5 (10%) 3 (6%) 4 (8%) 1 (2%) 6 (12%)
Pigmentation 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 21 (42%) 25 (50%) 28 (56%) 21 (43%) 18 (36%)
Hepatocyte, Degeneration, Cystic 1 (2%) 1 (2%)
Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic 31 (62%) 32 (64%) 25 (50%) 14 (29%) 18 (36%)
Mesentery (11) (9) (6) (9) (8)
Hemorrhage 1 (13%)
Inflammation, Chronic 1 (17%)
Fat, Inflammation, Chronic 4 (36%) 8 (89%) 4 (67%) 8 (89%) 7 (88%)
Fat, Mineralization 8 (73%) 5 (56%) 2 (33%) 5 (56%) 3 (38%)
Fat, Necrosis 9 (82%) 7 (78%) 5 (83%) 9 (100%) 7 (88%)
Fat, Pigmentation 1 (13%)
Oral Mucosa (12) (11) (24) (18) (5)
Foreign Body 11 (92%) 9 (82%) 24 (100%) 17 (94%) 4 (80%)
Gingival, Hyperplasia, Squamous 1 (9%)
Gingival, Inflammation, Chronic Active 5 (42%) 8 (73%) 8 (33%) 3 (17%) 1 (20%)
Gingival, Necrosis 1 (20%)
Pancreas (50) (50) (50) (49) (50)
Basophilic Focus 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Acinus, Atrophy 12 (24%) 14 (28%) 14 (28%) 5 (10%) 11 (22%)
Acinus, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Duct, Cyst 8 (16%) 4 (8%) 4 (8%) 1 (2%)
Salivary Glands (50) (50) (49) (49) (50)
Atrophy 11 (22%) 19 (38%) 8 (16%) 5 (10%) 11 (22%)
Basophilic Focus 10 (20%) 7 (14%) 6 (12%) 6 (12%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Stomach, Forestomach (50) (50) (50) (49) (50)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Epithelium, Hyperkeratosis 2 (4%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Epithelium, Ulcer 1 (2%) 2 (4%)
Stomach, Glandular (50) (50) (50) (49) (50)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%)
Epithelium, Erosion 2 (4%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Epithelium, Ulcer 2 (4%)
Glands, Ectasia 39 (78%) 36 (72%) 36 (72%) 39 (80%) 38 (76%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49) (50)
Cardiomyopathy 36 (72%) 45 (90%) 45 (90%) 43 (88%) 44 (88%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Atrium, Thrombosis 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 5 (10%) 2 (4%) 1 (2%)
Hyperplasia 10 (20%) 17 (34%) 9 (18%) 12 (24%) 10 (20%)
Hypertrophy 1 (2%) 4 (8%) 2 (4%) 3 (6%) 2 (4%)
Necrosis 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 20 (40%) 18 (36%) 25 (50%) 19 (39%) 20 (40%)
Adrenal Medulla (50) (50) (50) (49) (50)
Hyperplasia 3 (6%) 6 (12%) 3 (6%) 3 (6%) 3 (6%)
Islets, Pancreatic (50) (50) (50) (49) (50)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (50) (49) (50)
Pars Distalis, Angiectasis 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Pars Distalis, Cyst 30 (60%) 27 (54%) 27 (54%) 19 (39%) 22 (44%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 24 (48%) 19 (38%) 21 (42%) 23 (47%) 21 (42%)
Pars Distalis, Mineralization 1 (2%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (49) (49) (50)
Ectopic Thymus 1 (2%)
Inflammation, Chronic 1 (2%)
Ultimobranchial Cyst 1 (2%) 2 (4%) 1 (2%)
C-Cell, Hyperplasia 23 (46%) 33 (66%) 23 (47%) 28 (57%) 21 (42%)
Follicle, Cyst 2 (4%) 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (49) (50)
Hyperplasia 11 (22%) 11 (22%) 17 (34%) 11 (22%) 7 (14%)
Inflammation, Chronic Active 13 (27%) 9 (18%) 21 (42%) 15 (31%) 12 (24%)
Mineralization 1 (2%) 1 (2%)
Duct, Cyst 11 (22%) 16 (32%) 7 (14%) 9 (18%) 11 (22%)
Ovary (50) (50) (50) (49) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Cyst 9 (18%) 5 (10%) 5 (10%) 4 (8%) 2 (4%)
Mineralization 1 (2%) 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (49) (50)
Hemorrhage 1 (2%)
Hydrometra 2 (4%) 2 (4%) 5 (10%) 5 (10%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Cervix, Cyst, Squamous 1 (2%)
Cervix, Epithelium, Hyperplasia 1 (2%)
Endometrium, Hyperplasia, Cystic 2 (4%) 5 (10%) 2 (4%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49) (50)
Hyperplasia 15 (30%) 16 (32%) 13 (26%) 11 (22%) 13 (26%)
Myelofibrosis 3 (6%) 2 (4%) 2 (4%) 4 (8%)
Lymph Node (30) (25) (26) (24) (27)
Deep Cervical, Ectasia 1 (3%) 1 (4%) 3 (13%)
Deep Cervical, Hyperplasia, Lymphoid 1 (4%) 3 (13%) 3 (11%)
Deep Cervical, Inflammation, Chronic 1 (4%)
Deep Cervical, Pigmentation 1 (4%)
Lumbar, Ectasia 1 (3%)
Mediastinal, Ectasia 15 (50%) 17 (68%) 21 (81%) 20 (83%) 21 (78%)
Mediastinal, Hyperplasia, Lymphoid 19 (63%) 20 (80%) 21 (81%) 20 (83%) 22 (81%)
Mediastinal, Inflammation, Chronic 1 (4%)
Mediastinal, Pigmentation 1 (3%) 4 (15%) 1 (4%) 2 (7%)
Lymph Node, Mandibular (1) (2) (1) (2)
Ectasia 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mesenteric (50) (50) (50) (49) (50)
Ectasia 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (50) (50) (49) (49) (50)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 12 (24%) 5 (10%) 8 (16%) 3 (6%) 6 (12%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Pigmentation 1 (2%) 1 (2%) 2 (4%)
Thymus (43) (49) (47) (48) (47)
Ectopic Parathyroid Gland 4 (9%) 4 (8%) 3 (6%) 2 (4%) 6 (13%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49) (50)
Cyst 5 (10%) 3 (6%) 3 (6%) 3 (6%)
Cyst, Multiple 1 (2%)
Hyperplasia, Cystic 43 (86%) 47 (94%) 45 (90%) 37 (76%) 42 (84%)
Skin (50) (50) (50) (49) (50)
Cyst Epithelial Inclusion 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Epidermis, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49) (50)
Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49) (50)
Compression 2 (4%) 3 (6%) 3 (6%) 2 (4%) 5 (10%)
Hemorrhage 2 (4%) 2 (4%) 3 (6%)
Hydrocephalus 2 (4%) 5 (10%) 10 (20%) 5 (10%) 8 (16%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Meninges, Inflammation, Chronic Active 1 (2%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49) (50)
Congestion 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 31 (62%) 36 (72%) 40 (80%) 37 (76%) 33 (66%)
Metaplasia, Squamous 1 (2%)
Mineralization 45 (90%) 45 (90%) 47 (94%) 45 (92%) 44 (88%)
Pigmentation 44 (88%) 47 (94%) 44 (88%) 44 (90%) 44 (88%)
Alveolar Epithelium, Hyperplasia 12 (24%) 12 (24%) 15 (30%) 13 (27%) 9 (18%)
Alveolar Epithelium, Metaplasia, Focal,
Squamous 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 44 (88%) 47 (94%) 44 (88%) 44 (90%) 45 (90%)
Nose (50) (50) (50) (49) (50)
Foreign Body 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%) 2 (4%)
Thrombosis 2 (4%) 3 (6%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 5 (10%) 3 (6%) 6 (12%) 2 (4%)
Trachea (50) (50) (50) (49) (50)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (1) (2)
Lens, Cataract 1 (100%) 3 (100%) 2 (100%)
Retina, Degeneration 1 (100%) 3 (100%) 2 (100%)
Retina, Hemorrhage 1 (100%)
Zymbal's Gland (1) (2)
Cyst 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49) (50)
Accumulation, Hyaline Droplet 1 (2%)
Atrophy 1 (2%)
Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Lipocyte 1 (2%)
Mineralization 30 (60%) 38 (76%) 28 (56%) 33 (67%) 30 (60%)
Nephropathy 39 (78%) 43 (86%) 41 (82%) 38 (78%) 40 (80%)
Pigmentation 1 (2%) 1 (2%)
Pelvis, Inflammation, Suppurative 1 (2%)
Urinary Bladder (50) (50) (50) (49) (50)
Transitional Epithelium, Hyperplasia 1 (2%)
Transitional Epithelium, Metaplasia, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 14 13 11 11 6
Natural Death 7 6 3 12 3
Survivors
Terminal Sacrifice 29 31 36 27 41
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50) (50)
Parasite Metazoan 3 (6%) 4 (8%) 3 (6%) 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50) (50)
Parasite Metazoan 10 (20%) 4 (8%) 5 (10%) 8 (16%) 4 (8%)
Liver (50) (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 25 (50%) 26 (52%) 32 (64%) 23 (46%) 33 (66%)
Clear Cell Focus 1 (2%) 1 (2%) 3 (6%)
Eosinophilic Focus 2 (4%) 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 2 (4%) 2 (4%) 1 (2%) 5 (10%) 4 (8%)
Inflammation, Chronic Active 34 (68%) 38 (76%) 38 (76%) 31 (62%) 39 (78%)
Mixed Cell Focus 18 (36%) 29 (58%) 32 (64%) 20 (40%) 32 (64%)
Necrosis 2 (4%) 5 (10%) 2 (4%) 3 (6%) 5 (10%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 45 (90%) 46 (92%) 45 (90%) 43 (86%) 43 (86%)
Hepatocyte, Degeneration, Cystic 4 (8%) 7 (14%) 3 (6%) 4 (8%) 5 (10%)
Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Hepatocyte, Hypertrophy 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 23 (46%) 37 (74%) 36 (72%) 32 (64%) 34 (68%)
Portal, Fibrosis 1 (2%)
Mesentery (14) (5) (8) (9) (12)
Fat, Inflammation, Chronic 11 (79%) 2 (40%) 3 (38%) 6 (67%) 9 (75%)
Fat, Mineralization 8 (57%) 2 (40%) 2 (25%) 5 (56%) 6 (50%)
Fat, Necrosis 11 (79%) 2 (40%) 3 (38%) 8 (89%) 10 (83%)
Oral Mucosa (13) (13) (14) (12) (24)
Foreign Body 13 (100%) 12 (92%) 12 (86%) 10 (83%) 22 (92%)
Gingival, Inflammation, Chronic Active 9 (69%) 4 (31%) 9 (64%) 6 (50%) 12 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (50) (50) (50)
Basophilic Focus 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Pigmentation 1 (2%)
Acinus, Atrophy 13 (26%) 25 (50%) 20 (40%) 23 (46%) 16 (32%)
Acinus, Hyperplasia 2 (4%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Duct, Cyst 2 (4%) 3 (6%) 7 (14%) 3 (6%) 10 (20%)
Salivary Glands (50) (50) (50) (50) (50)
Atrophy 8 (16%) 5 (10%) 7 (14%) 6 (12%) 1 (2%)
Basophilic Focus 16 (32%) 19 (38%) 10 (20%) 18 (36%) 24 (48%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50) (50)
Diverticulum 1 (2%)
Inflammation, Chronic Active 4 (8%) 3 (6%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Epithelium, Hyperkeratosis 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Epithelium, Hyperplasia 5 (10%) 3 (6%) 3 (6%) 3 (6%) 1 (2%)
Epithelium, Ulcer 5 (10%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Epithelium, Erosion 4 (8%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Epithelium, Necrosis 1 (2%)
Epithelium, Ulcer 1 (2%) 1 (2%) 1 (2%)
Glands, Ectasia 34 (68%) 34 (68%) 37 (74%) 27 (54%) 39 (78%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50) (50)
Aorta, Mineralization 1 (2%) 1 (2%) 1 (2%)
Media, Mineralization 1 (2%)
Heart (50) (50) (50) (50) (50)
Cardiomyopathy 44 (88%) 46 (92%) 46 (92%) 45 (90%) 50 (100%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 2 (4%) 1 (2%)
Atrium, Thrombosis 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Angiectasis 1 (2%)
Atypia Cellular 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 5 (10%) 2 (4%) 7 (14%)
Hyperplasia 12 (24%) 9 (18%) 16 (32%) 14 (28%) 13 (26%)
Hypertrophy 2 (4%) 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Vacuolization Cytoplasmic 30 (60%) 27 (54%) 30 (60%) 33 (66%) 24 (48%)
Adrenal Medulla (50) (50) (50) (50) (50)
Hyperplasia 8 (16%) 9 (18%) 14 (28%) 8 (16%) 5 (10%)
Thrombosis 1 (2%)
Islets, Pancreatic (50) (50) (50) (50) (50)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (50) (50) (50)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 4 (8%) 6 (12%) 3 (6%) 4 (8%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 16 (32%) 13 (26%) 16 (32%) 18 (36%) 21 (42%)
Pars Distalis, Inflammation, Suppurative 1 (2%)
Pars Distalis, Mineralization 1 (2%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%) 2 (4%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50) (50)
Ultimobranchial Cyst 3 (6%) 1 (2%) 2 (4%) 2 (4%)
C-Cell, Hyperplasia 17 (34%) 22 (44%) 20 (40%) 15 (30%) 23 (46%)
Follicle, Cyst 2 (4%) 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Follicular Cell, Hyperplasia 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50) (50)
Granuloma Sperm 3 (6%) 1 (2%) 6 (12%) 4 (8%) 5 (10%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Preputial Gland (50) (50) (49) (50) (50)
Hyperplasia 7 (14%) 2 (4%) 2 (4%) 3 (6%)
Inflammation, Chronic, Diffuse, Suppurative 1 (2%)
Inflammation, Chronic Active 49 (98%) 43 (86%) 47 (96%) 43 (86%) 49 (98%)
Mineralization 2 (4%) 1 (2%)
Duct, Ectasia 5 (10%) 7 (14%) 7 (14%) 6 (12%) 9 (18%)
Prostate, NOS (50) (50) (49) (49) (50)
Cyst 1 (2%) 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Degeneration 1 (2%)
Inflammation, Chronic Active 21 (42%) 23 (46%) 20 (41%) 20 (41%) 15 (30%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 4 (8%) 1 (2%) 8 (16%) 6 (12%)
Seminal Vesicle (50) (50) (50) (49) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Testes (50) (50) (49) (50) (50)
Atrophy 1 (2%)
Cyst 1 (2%)
Mineralization 42 (84%) 38 (76%) 44 (90%) 36 (72%) 41 (82%)
Germinal Epithelium, Atrophy 4 (8%) 1 (2%) 3 (6%) 2 (4%)
Interstitial Cell, Hyperplasia 10 (20%) 8 (16%) 4 (8%) 7 (14%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Hyperplasia 29 (58%) 33 (66%) 21 (42%) 26 (52%) 22 (44%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (24) (20) (28) (28) (20)
Ectasia 2 (8%) 1 (4%)
Hyperplasia, Lymphoid 1 (4%)
Bronchial, Ectasia 1 (4%)
Bronchial, Hyperplasia, Lymphoid 1 (4%)
Deep Cervical, Ectasia 3 (13%) 4 (14%) 4 (14%) 2 (10%)
Deep Cervical, Hyperplasia, Lymphoid 3 (13%) 1 (5%) 4 (14%) 4 (14%) 3 (15%)
Mediastinal, Ectasia 6 (25%) 10 (50%) 11 (39%) 11 (39%) 7 (35%)
Mediastinal, Hyperplasia, Lymphoid 7 (29%) 10 (50%) 10 (36%) 12 (43%) 12 (60%)
Mediastinal, Pigmentation 1 (4%)
Pancreatic, Ectasia 1 (4%)
Lymph Node, Mandibular (2) (4)
Ectasia 2 (100%) 1 (25%)
Lymph Node, Mesenteric (50) (50) (50) (49) (50)
Ectasia 2 (4%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50) (50) (50) (50) (50)
Congestion 2 (4%)
Fibrosis 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 2 (4%) 5 (10%) 10 (20%) 4 (8%) 6 (12%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%) 2 (4%) 1 (2%) 5 (10%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Lymphoid Follicle, Depletion Cellular 1 (2%)
Thymus (43) (44) (45) (46) (43)
Ectopic Parathyroid Gland 2 (5%) 1 (2%) 2 (4%) 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50) (50)
Cyst 1 (2%)
Hyperplasia, Cystic 45 (90%) 47 (94%) 41 (82%) 45 (90%) 47 (94%)
Inflammation, Chronic Active 1 (2%)
Skin (50) (50) (50) (50) (50)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Dermis, Fibrosis 1 (2%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
Hair Follicle, Sebaceous Gland, Atrophy 1 (2%)
Subcutaneous Tissue, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50)
Compression 3 (6%) 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Hemorrhage 6 (12%) 1 (2%) 4 (8%) 2 (4%) 1 (2%)
Hydrocephalus 4 (8%) 3 (6%) 3 (6%) 5 (10%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Mineralization 1 (2%)
Necrosis 3 (6%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Spinal Cord (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Fibrosis 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 26 (52%) 32 (64%) 31 (62%) 27 (54%) 36 (72%)
Metaplasia, Osseous 1 (2%)
Mineralization 45 (90%) 46 (92%) 47 (94%) 48 (96%) 49 (98%)
Necrosis 1 (2%)
Pigmentation 30 (60%) 35 (70%) 32 (64%) 23 (46%) 35 (70%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 10 (20%) 10 (20%) 9 (18%) 11 (22%)
Alveolar Epithelium, Metaplasia, Focal,
Squamous 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 31 (62%) 36 (72%) 32 (64%) 24 (48%) 35 (70%)
Nose (50) (50) (50) (50) (50)
Foreign Body 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 4 (8%) 2 (4%) 3 (6%) 4 (8%)
Keratin Cyst 1 (2%)
Polyp Inflammatory 1 (2%)
Thrombosis 1 (2%) 2 (4%) 3 (6%) 6 (12%) 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 12 (24%) 6 (12%) 4 (8%) 5 (10%) 9 (18%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2) (1)
Cornea, Inflammation, Chronic Active 1 (50%)
Cornea, Inflammation, Suppurative 1 (50%)
Lens, Cataract 1 (50%) 1 (100%) 1 (50%) 1 (100%)
Lens, Degeneration 1 (50%)
Retina, Degeneration 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 56111-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 15:19:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%) 1 (2%)
Atrophy 1 (2%)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Mineralization 38 (76%) 31 (62%) 30 (60%) 32 (64%) 38 (76%)
Necrosis 1 (2%) 1 (2%)
Nephropathy 47 (94%) 47 (94%) 49 (98%) 44 (88%) 45 (90%)
Cortex, Medulla, Fibrosis 1 (2%)
Cortex, Medulla, Pigmentation 1 (2%)
Cortex, Medulla, Pelvis, Cyst 1 (2%)
Medulla, Necrosis 1 (2%)
Medulla, Renal Tubule, Dilatation 1 (2%)
Urinary Bladder (50) (50) (49) (49) (50)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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