TDMS Study 56111-04 Pathology Tables
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 14371-10-9
Lock Date: 06/28/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Natural Death 5 6 9 5 3
Moribund Sacrifice 2 3 4 1 4
Survivors
Terminal Sacrifice 42 41 36 44 43
Natural Death 1 1
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50) (50)
Hyperkeratosis 2 (4%) 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Gallbladder (50) (50) (50) (50) (50)
Cyst 1 (2%)
Inflammation 3 (6%) 6 (12%) 5 (10%) 5 (10%) 3 (6%)
Intestine Small, Duodenum (50) (49) (50) (50) (50)
Necrosis 1 (2%)
Regeneration 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50) (50)
Ulcer 1 (2%)
Epithelium, Atrophy 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Necrosis 1 (2%)
Liver (50) (49) (50) (50) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%) 4 (8%) 2 (4%) 1 (2%)
Eosinophilic Focus 3 (6%) 1 (2%) 2 (4%)
Fatty Change 5 (10%) 4 (8%) 8 (16%) 4 (8%) 7 (14%)
Hematopoietic Cell Proliferation 4 (8%) 6 (12%) 3 (6%) 2 (4%) 5 (10%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation 39 (78%) 42 (86%) 36 (72%) 38 (76%) 41 (82%)
Mixed Cell Focus 2 (4%) 1 (2%) 3 (6%)
Necrosis 6 (12%) 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Pigmentation 2 (4%) 3 (6%) 4 (8%) 2 (4%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Portal, Infiltration Cellular, Lymphocyte 26 (52%) 32 (65%) 25 (50%) 31 (62%) 26 (52%)
Mesentery (3) (4) (5) (4) (1)
Inflammation 1 (25%)
Fat, Mineralization 2 (40%) 1 (100%)
Fat, Necrosis 3 (75%) 2 (40%) 1 (25%) 1 (100%)
Pancreas (50) (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%) 1 (2%)
Inflammation 21 (42%) 25 (50%) 16 (32%) 24 (48%) 18 (36%)
Salivary Glands (48) (50) (48) (49) (50)
Atrophy 1 (2%)
Inflammation 25 (52%) 32 (64%) 27 (56%) 27 (55%) 27 (54%)
Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (50) (50)
Hyperkeratosis 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 1 (2%)
Ulcer 1 (2%) 2 (4%)
Stomach, Glandular (50) (50) (50) (50) (50)
Inflammation 1 (2%)
Mineralization 1 (2%) 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Tooth (2) (1) (1)
Malformation 1 (50%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50) (50)
Aorta, Inflammation 1 (2%) 1 (2%) 1 (2%)
Heart (49) (50) (50) (50) (50)
Cardiomyopathy 1 (2%) 1 (2%) 2 (4%)
Inflammation 1 (2%) 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 6 (12%) 2 (4%) 2 (4%)
Hypertrophy 4 (8%) 4 (8%) 2 (4%) 2 (4%) 1 (2%)
Pigmentation 32 (64%) 34 (68%) 26 (52%) 32 (64%) 29 (58%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 36 (72%) 34 (68%) 31 (62%) 37 (74%) 33 (66%)
Subcapsular, Hyperplasia 50 (100%) 49 (98%) 50 (100%) 50 (100%) 49 (98%)
Adrenal Medulla (49) (50) (50) (50) (50)
Hyperplasia 3 (6%) 1 (2%) 3 (6%) 2 (4%)
Islets, Pancreatic (50) (50) (50) (50) (50)
Hyperplasia 1 (2%) 3 (6%) 4 (8%) 2 (4%)
Parathyroid Gland (41) (44) (40) (41) (44)
Cyst 1 (2%)
Pituitary Gland (48) (49) (50) (49) (50)
Angiectasis 1 (2%)
Cyst 1 (2%) 1 (2%) 2 (4%)
Inflammation 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 5 (10%) 6 (12%) 2 (4%) 4 (8%)
Thyroid Gland (48) (50) (49) (50) (50)
Inflammation 2 (4%)
Follicle, Cyst 7 (15%) 3 (6%) 4 (8%) 10 (20%) 4 (8%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (49) (50)
Cyst 1 (2%)
Inflammation 32 (64%) 35 (71%) 30 (60%) 36 (73%) 33 (66%)
Inflammation, Suppurative 1 (2%)
Ovary (50) (50) (50) (49) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Cyst 13 (26%) 9 (18%) 8 (16%) 11 (22%) 11 (22%)
Cyst, Multiple 1 (2%)
Inflammation 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%) 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Oviduct (1) (1) (2) (3) (4)
Inflammation 1 (100%) 1 (25%)
Uterus (50) (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Hydrometra 1 (2%) 1 (2%)
Inflammation 1 (2%) 7 (14%) 3 (6%) 2 (4%) 6 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ulcer 1 (2%)
Endometrium, Hyperplasia, Cystic 43 (86%) 42 (84%) 46 (92%) 41 (82%) 48 (96%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Hyperplasia 11 (22%) 10 (20%) 10 (20%) 12 (24%) 12 (24%)
Infiltration Cellular, Lymphocyte 1 (2%)
Lymph Node (7) (5) (7) (10) (7)
Lumbar, Infiltration Cellular, Plasma Cell 1 (14%)
Renal, Ectasia 1 (14%)
Lymph Node, Mandibular (46) (47) (45) (49) (47)
Atrophy 2 (4%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (49) (50) (49) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Ectasia 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation 1 (2%)
Spleen (48) (49) (50) (50) (50)
Hematopoietic Cell Proliferation 11 (23%) 16 (33%) 15 (30%) 9 (18%) 11 (22%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Pigmentation 1 (2%)
Lymphoid Follicle, Atrophy 2 (4%) 2 (4%)
Lymphoid Follicle, Hyperplasia 2 (4%) 4 (8%) 1 (2%) 4 (8%)
Thymus (46) (47) (46) (47) (47)
Atrophy 5 (11%) 2 (4%) 3 (7%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation 1 (2%)
Duct, Dilatation 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Skin (50) (50) (50) (50) (50)
Hyperkeratosis 1 (2%)
Subcutaneous Tissue, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Myelofibrosis 24 (48%) 27 (54%) 23 (46%) 34 (68%) 38 (76%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Choroid Plexus, Infiltration Cellular,
Lymphocyte 1 (2%)
Choroid Plexus, Inflammation 1 (2%)
Medulla, Degeneration 1 (2%)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Meninges, Inflammation 2 (4%)
Spinal Cord (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation 1 (2%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%) 1 (2%)
Nose (49) (50) (50) (50) (50)
Foreign Body 1 (2%) 1 (2%)
Inflammation 2 (4%) 5 (10%) 3 (6%) 4 (8%) 2 (4%)
Glands, Inflammation, Focal, Granulomatous 1 (2%)
Nasolacrimal Duct, Inflammation 2 (4%) 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 17 (35%) 23 (46%) 25 (50%) 22 (44%)
Olfactory Epithelium, Pigmentation 8 (16%) 46 (92%)
Trachea (48) (50) (49) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Hyperplasia 1 (100%)
Cornea, Inflammation 1 (100%) 1 (100%)
Harderian Gland (2) (1) (4) (5)
Inflammation 2 (100%) 1 (25%) 2 (40%)
Lacrimal Gland (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Cyst 1 (2%)
Hydronephrosis 1 (2%) 1 (2%) 1 (2%)
Infarct 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Lymphocyte 37 (74%) 44 (88%) 39 (78%) 42 (84%) 37 (74%)
Inflammation 1 (2%) 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Mineralization 4 (8%) 4 (8%) 1 (2%) 2 (4%) 6 (12%)
Necrosis 1 (2%)
Nephropathy 7 (14%) 11 (22%) 4 (8%) 12 (24%) 8 (16%)
Artery, Inflammation 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Dilatation 24 (48%) 25 (50%) 30 (60%) 22 (44%) 32 (64%)
Urinary Bladder (50) (50) (50) (50) (50)
Inflammation 34 (68%) 33 (66%) 39 (78%) 33 (66%) 33 (66%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Natural Death 6 3 4 9
Moribund Sacrifice 2 1
Survivors
Terminal Sacrifice 43 45 46 39 49
Natural Death 1 2
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50) (50)
Hyperkeratosis 4 (8%) 2 (4%) 2 (4%) 4 (8%)
Gallbladder (50) (50) (50) (50) (49)
Inflammation 2 (4%) 4 (8%) 2 (4%) 2 (4%) 4 (8%)
Intestine Large, Colon (50) (50) (50) (50) (50)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50) (50)
Edema 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50) (50)
Lymphoid Tissue, Hyperplasia 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50) (49)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50) (50)
Atrophy 1 (2%)
Cyst 1 (2%)
Diverticulum 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation 1 (2%)
Peyer's Patch, Hyperplasia 2 (4%)
Intestine Small, Ileum (50) (50) (50) (50) (50)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 3 (6%) 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Fatty Change 3 (6%) 3 (6%) 4 (8%) 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation 26 (52%) 33 (66%) 34 (68%) 28 (56%) 27 (54%)
Mitotic Alteration 1 (2%)
Mixed Cell Focus 3 (6%) 5 (10%) 3 (6%) 3 (6%) 6 (12%)
Necrosis 3 (6%) 6 (12%) 4 (8%) 4 (8%) 3 (6%)
Pigmentation 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Degeneration 1 (2%)
Portal, Infiltration Cellular, Lymphocyte 1 (2%) 3 (6%) 6 (12%) 8 (16%) 3 (6%)
Mesentery (2) (1)
Fat, Inflammation 1 (50%)
Fat, Necrosis 1 (50%)
Pancreas (50) (50) (50) (50) (50)
Atrophy 1 (2%)
Cyst 2 (4%)
Inflammation 8 (16%) 10 (20%) 8 (16%) 14 (28%) 10 (20%)
Salivary Glands (50) (50) (50) (49) (50)
Atrophy 3 (6%) 1 (2%)
Inflammation 30 (60%) 31 (62%) 33 (66%) 26 (53%) 29 (58%)
Mineralization 2 (4%)
Stomach, Forestomach (48) (50) (50) (48) (50)
Hyperkeratosis 2 (4%) 2 (4%) 3 (6%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50) (50)
Mineralization 1 (2%)
Ulcer 1 (2%)
Tooth (1) (1) (2)
Malformation 1 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (49) (50) (50) (50)
Aorta, Inflammation 1 (2%) 1 (2%)
Aorta, Thrombosis 1 (2%)
Heart (50) (50) (50) (50) (50)
Cardiomyopathy 1 (2%) 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Mineralization 5 (10%)
Artery, Inflammation 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (49) (50)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 23 (47%) 23 (46%) 22 (44%) 24 (49%) 19 (38%)
Subcapsular, Hyperplasia 39 (80%) 46 (92%) 43 (86%) 44 (90%) 42 (84%)
Adrenal Medulla (49) (50) (50) (49) (50)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 4 (8%) 4 (8%) 5 (10%) 3 (6%) 4 (8%)
Pituitary Gland (48) (50) (49) (50) (49)
Angiectasis 1 (2%)
Cyst 2 (4%) 1 (2%) 3 (6%)
Pars Distalis, Hyperplasia 5 (10%) 5 (10%) 6 (12%) 4 (8%) 5 (10%)
Thyroid Gland (50) (49) (50) (50) (50)
Inflammation 1 (2%) 1 (2%)
Follicle, Cyst 6 (12%) 4 (8%) 4 (8%) 5 (10%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Inflammation 1 (100%) 1 (100%)
Epididymis (50) (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Mineralization 3 (6%) 2 (4%) 2 (4%)
Preputial Gland (50) (50) (50) (50) (50)
Inflammation 26 (52%) 29 (58%) 31 (62%) 27 (54%) 22 (44%)
Duct, Ectasia 15 (30%) 20 (40%) 27 (54%) 17 (34%) 13 (26%)
Duct, Hyperplasia, Squamous 1 (2%)
Testes (50) (50) (50) (50) (50)
Mineralization 1 (2%) 3 (6%) 3 (6%) 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bone Marrow (50) (50) (50) (50) (50)
Hyperplasia 17 (34%) 14 (28%) 19 (38%) 20 (40%) 13 (26%)
Necrosis 1 (2%)
Lymph Node (3) (2) (2) (3) (2)
Mediastinal, Hyperplasia 1 (33%)
Lymph Node, Mandibular (49) (49) (49) (46) (48)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mesenteric (48) (49) (46) (46) (50)
Angiectasis 1 (2%)
Atrophy 3 (6%) 1 (2%) 2 (4%)
Ectasia 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Mineralization 1 (2%)
Spleen (50) (50) (50) (49) (50)
Hematopoietic Cell Proliferation 7 (14%) 8 (16%) 10 (20%) 8 (16%) 5 (10%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Thymus (44) (43) (44) (44) (49)
Atrophy 2 (5%) 3 (7%) 3 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50) (50)
Inflammation 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Myelofibrosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (1)
Inflammation 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Cerebellum, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Inflammation 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Metaplasia, Osseous 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%) 7 (14%) 5 (10%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Nose (48) (48) (48) (48) (50)
Foreign Body 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Inflammation 3 (6%) 2 (4%) 6 (13%) 4 (8%)
Nasolacrimal Duct, Foreign Body 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 1 (2%)
Olfactory Epithelium, Pigmentation 3 (6%) 26 (52%)
Olfactory Epithelium, Respiratory Epithelium,
Degeneration 1 (2%)
Trachea (50) (50) (50) (50) (50)
Inflammation 1 (2%)
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SPECIAL SENSES SYSTEM
Harderian Gland (4) (4) (4) (1) (3)
Inflammation 1 (25%)
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URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Atrophy 1 (2%)
Cyst 2 (4%) 3 (6%) 3 (6%) 3 (6%)
Cytoplasmic Alteration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 56111-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRANS-CINNAMALDEHYDE Date: 09/26/01
Route: DOSED FEED Time: 14:40:37
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B6C3F1 MICE MALE UNTREATD VEHICLE .312% .625% 1.25%
CONTROL CONTROL
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URINARY SYSTEM - CONT
Fibrosis 1 (2%)
Infarct 2 (4%) 5 (10%) 2 (4%) 2 (4%)
Infiltration Cellular, Lymphocyte 39 (78%) 39 (78%) 42 (84%) 40 (80%) 44 (88%)
Inflammation 2 (4%) 2 (4%) 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Mineralization 42 (84%) 44 (88%) 49 (98%) 45 (90%) 46 (92%)
Nephropathy 46 (92%) 47 (94%) 46 (92%) 38 (76%) 42 (84%)
Artery, Inflammation 1 (2%) 1 (2%)
Glomerulus, Dilatation 1 (2%)
Renal Tubule, Dilatation 6 (12%) 7 (14%) 5 (10%) 8 (16%) 9 (18%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Urinary Bladder (50) (50) (50) (50) (50)
Inflammation 20 (40%) 16 (32%) 20 (40%) 18 (36%) 21 (42%)
a Number of animals examined microscopically at site and number of animals with lesion
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