TDMS Study 56348-03 Pathology Tables
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
Facility: Battelle Columbus Laboratory
Chemical CAS #: 5392-40-5
Lock Date: 03/25/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 12 10 11 11 12
Natural Death 3 3 3 2
Survivors
Terminal Sacrifice 34 40 36 36 36
Natural Death 1
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50) (50)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50) (50)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (49) (50)
Sarcoma 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50) (50)
Liver (50) (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Mesentery (10) (5) (1) (5) (7)
Oral Mucosa (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (50) (50)
Salivary Glands (50) (50) (50) (50) (50)
Stomach, Forestomach (50) (49) (50) (50) (50)
Stomach, Glandular (50) (50) (50) (50) (50)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50)
Schwannoma Malignant 1 (2%) 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (49) (50) (50) (50) (50)
Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50) (49)
Adenoma 2 (4%) 1 (2%)
Parathyroid Gland (43) (43) (40) (43) (47)
Adenoma 2 (5%)
Pituitary Gland (50) (50) (50) (50) (49)
Pars Distalis, Adenoma 12 (24%) 17 (34%) 11 (22%) 17 (34%) 13 (27%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (50) (50)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 7 (14%) 13 (26%) 9 (18%) 9 (18%) 11 (22%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (49) (49) (50) (49)
Adenoma 9 (18%) 5 (10%) 2 (4%) 4 (8%) 1 (2%)
Carcinoma 1 (2%)
Bilateral, Adenoma 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50) (50)
Uterus (50) (50) (50) (50) (50)
Adenoma 1 (2%)
Fibroma 1 (2%)
Hemangioma 1 (2%)
Polyp Stromal 13 (26%) 4 (8%) 8 (16%) 8 (16%) 10 (20%)
Polyp Stromal, Multiple 1 (2%)
Schwannoma Malignant 1 (2%)
Cervix, Leiomyosarcoma 1 (2%)
Cervix, Polyp Stromal 1 (2%)
Page 3
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Vagina (2) (1) (2)
Schwannoma Malignant, Metastatic, Skin 1 (50%)
Schwannoma Malignant, Metastatic, Uterus 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Lymph Node (7) (4) (7) (10) (5)
Mediastinal, Carcinoma, Metastatic, Mammary
Gland 1 (10%)
Lymph Node, Mandibular (50) (50) (50) (50) (50)
Lymph Node, Mesenteric (50) (50) (50) (50) (50)
Spleen (50) (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Thymus (49) (47) (49) (48) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50) (50)
Carcinoma 1 (2%) 3 (6%)
Fibroadenoma 22 (44%) 21 (42%) 16 (32%) 18 (36%) 15 (30%)
Fibroadenoma, Multiple 4 (8%) 6 (12%) 6 (12%) 1 (2%)
Hemangioma 1 (2%)
Skin (50) (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 2 (4%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Schwannoma Malignant, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 2 (4%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Mediastinum, Carcinoma, Metastatic, Mammary
Gland 1 (2%)
Nose (50) (50) (50) (50) (50)
Adenoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (3) (1) (2)
Retrobulbar, Schwannoma Malignant 1 (50%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50) (50)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Page 5
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 10 (20%) 22 (44%) 14 (28%) 15 (30%)
Lymphoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 45 47 46 43
Total Primary Neoplasms 95 96 88 93 75
Total Animals with Benign Neoplasms 37 41 39 37 38
Total Benign Neoplasms 79 80 60 67 57
Total Animals with Malignant Neoplasms 15 15 26 22 17
Total Malignant Neoplasms 16 16 28 26 18
Total Animals with Metastatic Neoplasms 1 2 6
Total Metastatic Neoplasm 1 2 14
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 18 22 15 11 10
Natural Death 2 6 3 4 6
Survivors
Terminal Sacrifice 30 22 32 35 34
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50) (50)
Carcinoma 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Intestine Large, Cecum (50) (50) (50) (49) (50)
Intestine Small, Duodenum (50) (50) (50) (50) (50)
Intestine Small, Jejunum (50) (50) (50) (50) (50)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (50) (50) (49) (50) (50)
Liver (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Mesentery (8) (13) (11) (11) (5)
Fibrosarcoma 1 (20%)
Fibrous Histiocytoma, Metastatic, Skin 1 (8%)
Oral Mucosa (1) (2)
Squamous Cell Carcinoma 1 (100%) 1 (50%)
Pharyngeal, Squamous Cell Papilloma 1 (50%)
Pancreas (50) (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Fibroma 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Salivary Glands (50) (50) (50) (50) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Stomach, Forestomach (50) (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50) (50)
Tongue (1) (1) (1)
Page 8
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Papilloma 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Schwannoma Malignant 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (50) (50) (50)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 5 (10%) 3 (6%) 2 (4%) 2 (4%) 8 (16%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (49) (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Pituitary Gland (50) (50) (50) (50) (49)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Pars Distalis, Adenoma 8 (16%) 9 (18%) 7 (14%) 9 (18%) 6 (12%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 2 (4%)
Pars Nervosa, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 7 (14%) 4 (8%) 9 (18%) 10 (20%) 10 (20%)
C-Cell, Carcinoma 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 3 (6%) 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1) (1)
Adenoma 1 (100%)
Epididymis (50) (50) (50) (50) (50)
Preputial Gland (50) (50) (49) (50) (50)
Adenoma 4 (8%) 3 (6%) 5 (10%) 4 (8%) 3 (6%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50) (50)
Seminal Vesicle (50) (50) (50) (50) (50)
Testes (50) (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Bilateral, Interstitial Cell, Adenoma 46 (92%) 42 (84%) 46 (92%) 41 (82%) 44 (88%)
Interstitial Cell, Adenoma 3 (6%) 5 (10%) 3 (6%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lymph Node (15) (20) (10) (10) (12)
Mediastinal, Fibrous Histiocytoma,
Metastatic, Skin 1 (5%)
Lymph Node, Mandibular (50) (49) (50) (50) (50)
Lymph Node, Mesenteric (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hemangioma 1 (2%)
Spleen (50) (50) (50) (50) (49)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Thymus (50) (47) (49) (47) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49) (50)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Fibroadenoma 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Fibroadenoma, Multiple 3 (6%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Skin (50) (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%) 2 (4%) 1 (2%)
Basal Cell Carcinoma 1 (2%)
Page 10
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 4 (8%) 3 (6%) 2 (4%) 5 (10%) 4 (8%)
Keratoacanthoma, Multiple 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%) 1 (2%)
Dermis, Schwannoma Malignant 1 (2%)
Epidermis, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma,
Metastatic, Skin 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Myxoma 1 (2%)
Subcutaneous Tissue, Myxosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
Subcutaneous Tissue, Pinna, Melanoma
Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Rib, Carcinoma, Metastatic, Mammary Gland 1 (2%)
Skeletal Muscle (2)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Complex, Metastatic,
Adrenal Medulla 1 (2%)
Page 11
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Bronchiole, Carcinoma 1 (2%)
Nose (50) (50) (50) (50) (50)
Adenoma 1 (2%)
Trachea (50) (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3) (2) (3)
Melanoma Malignant 1 (50%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50) (50) (50)
Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50)
Leukemia Mononuclear 33 (66%) 35 (70%) 39 (78%) 32 (64%) 29 (58%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 2 (4%) 2 (4%) 4 (8%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 56348-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CITRAL Date: 07/05/01
Route: DOSED FEED Time: 15:28:02
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT VEHICLE 1000 PPM 2000 PPM 4000 PPM
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 50 49 50
Total Primary Neoplasms 143 134 143 138 129
Total Animals with Benign Neoplasms 50 47 50 48 48
Total Benign Neoplasms 97 86 91 92 87
Total Animals with Malignant Neoplasms 35 41 41 37 33
Total Malignant Neoplasms 46 48 52 46 42
Total Animals with Metastatic Neoplasms 1 4 1 1
Total Metastatic Neoplasm 1 17 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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