TDMS Study 56348-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Columbus CITRAL DATE: 06/09/00 EXPERIMENT: 56348 TEST: 03 TIME: 11:16:39 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-55384 ROUTE: DOSED FEED NTP C#: C56348 PATHOLOGIST: SINGER, ALLEN CAS: 5392-40-5 ------------------------------------------------------------------------------------------------------------------------------------ FINAL #1/RATS UNTREATED CONTROL VS VEHICLE CONTROL REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE 001 UNTREAT CONTROL INCLUDE 002 UNTREAT CONTROL INCLUDE 003 VEHICLE CONTROL INCLUDE 004 VEHICLE CONTROL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Columbus CITRAL DATE: 06/09/00 EXPERIMENT: 56348 TEST: 03 TIME: 11:16:39 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-55384 ROUTE: DOSED FEED NTP C#: C56348 PATHOLOGIST: SINGER, ALLEN CAS: 5392-40-5 CITRAL STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 726 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = UNTREAT CONTROL | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 | | | | UNCENSORED DEATHS | | 450 505 549 589 600 610 610 617 639 639 | | 653 660 660 674 674 674 688 693 695 712 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = VEHICLE CONTROL | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 | | | | UNCENSORED DEATHS | | 365 446 509 532 610 617 623 628 632 637 | | 639 639 653 660 660 660 663 674 674 678 | | 688 688 694 695 695 707 709 722 | | CENSORED DEATHS | | NONE | | | ================================================================================== CITRAL STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 726 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 726 (A) | | | |--------------------------------------------------------------------------------| | | | |UNTREAT | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 74.0 60.0 | |CONTROL | | | | | |VEHICLE | 100.0 100.0 100.0 98.0 98.0 96.0 92.0 92.0 66.0 44.0 | |CONTROL | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | UNTREAT VEHICLE | | CONTROL CONTROL | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 60.0% 44.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | ----- ----- | |(LIFE TABLE) | | | | | |MEAN DAY OF | 629.6 635.6 | |NATURAL DEATHS (C) | (14.9) (15.4) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 687.4 675.4 | |(STANDARD ERROR) | ( 9.0) (10.7) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) CITRAL STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 732 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = UNTREAT CONTROL | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 | | | | UNCENSORED DEATHS | | 508 519 588 595 609 622 627 635 636 650 | | 686 719 719 719 722 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = VEHICLE CONTROL | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 | | | | UNCENSORED DEATHS | | 62 491 652 677 687 694 697 708 708 715 | | CENSORED DEATHS | | NONE | | | ================================================================================== CITRAL STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 732 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 732 (A) | | | |--------------------------------------------------------------------------------| | | | |UNTREAT | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 80.0 70.0 | |CONTROL | | | | | |VEHICLE | 98.0 98.0 98.0 98.0 98.0 98.0 96.0 96.0 94.0 80.0 | |CONTROL | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | UNTREAT VEHICLE | | CONTROL CONTROL | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 70.0% 80.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | ----- ----- | |(LIFE TABLE) | | | | | |MEAN DAY OF | 636.9 609.1 | |NATURAL DEATHS (C) | (17.7) (64.2) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 703.5 707.4 | |(STANDARD ERROR) | ( 8.1) (14.2) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) CITRAL KAPLAN-MEIER SURVIVAL CURVES UNTREAT CONTROL = 1 VEHICLE CONTROL = 2 ------------------------------------------------------ SPECIES=RATS SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 | 2 2 1 1 | 2 1 2 1 1 | 2 11 2 P 90 + 1 12 E | R | 11221 C | E 80 + 21 1 N | 1 1 T | 2 2 1 1 | S 70 + U | 1 1 R | 2 2 11 V | 1 1 I 60 + 2 2 1 1 V | A | 22 L | 50 + 22 | 22 | 2 2 | 40 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 12 obs hidden. CITRAL KAPLAN-MEIER SURVIVAL CURVES UNTREAT CONTROL = 1 VEHICLE CONTROL = 2 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 | | 2 2 1 1 | 2 1 1 2 P 95 + E | 1 1 2 2 R | 1 1 2 2 C | E 90 + 1 1 22 N | T | 11 | 11 2 2 S 85 + U | R | 1 1 22 V | I 80 + 1 1 2 2 V | A | 1 1 L | 75 + | | 11 | 70 + 1 1 | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 1 obs hidden.