TDMS Study 56348-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus CITRAL DATE: 12/19/00
EXPERIMENT: 56348 TEST: 04 TIME: 11:28:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55384 ROUTE: DOSED FEED NTP C#: C56348
PATHOLOGIST: DR. M. RYAN CAS: 5392-40-5
------------------------------------------------------------------------------------------------------------------------------------
MICE/Untreated vs vehicle control
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 UNTREAT CONTROL
INCLUDE 002 UNTREAT CONTROL
INCLUDE 003 VEHICLE CONTROL
INCLUDE 004 VEHICLE CONTROL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus CITRAL DATE: 12/19/00
EXPERIMENT: 56348 TEST: 04 TIME: 11:28:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55384 ROUTE: DOSED FEED NTP C#: C56348
PATHOLOGIST: DR. M. RYAN CAS: 5392-40-5
CITRAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREAT CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 48 |
| |
| UNCENSORED DEATHS |
| 397 626 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 121 310 530 530 626 682 682 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CITRAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREAT | 100.0 100.0 100.0 100.0 98.0 98.0 98.0 98.0 96.0 96.0 |
|CONTROL | |
| | |
|VEHICLE | 100.0 98.0 98.0 96.0 96.0 96.0 92.0 92.0 90.0 86.0 |
|CONTROL | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREAT VEHICLE |
| CONTROL CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 96.0% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 511.5 497.3 |
|NATURAL DEATHS (C) | ( 115) (79.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 718.4 694.8 |
|(STANDARD ERROR) | ( 6.9) (15.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CITRAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREAT CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 1 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 242 242 243 544 545 557 660 709 722 |
| CENSORED DEATHS |
| 9 |
| |
|--------------------------------------------------------------------------------|
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 1 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 441 470 625 633 680 688 709 719 |
| CENSORED DEATHS |
| 114 |
| |
==================================================================================
CITRAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREAT | 100.0 100.0 93.9 93.9 93.9 93.9 89.8 87.8 85.7 81.6 |
|CONTROL | |
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 95.9 95.9 95.9 91.8 83.7 |
|CONTROL | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREAT VEHICLE |
| CONTROL CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 81.6% 83.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 496.0 620.6 |
|NATURAL DEATHS (C) | (67.2) (38.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 675.9 702.6 |
|(STANDARD ERROR) | (22.1) (14.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CITRAL
KAPLAN-MEIER SURVIVAL CURVES
UNTREAT CONTROL = 1
VEHICLE CONTROL = 2
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
|
|
|
98 + 2 2 1 1
|
P |
E |
R 96 + 2 2 1 1
C |
E |
N |
T 94 +
|
S |
U |
R 92 + 2 2
V |
I |
V |
A 90 + 2 2
L |
|
|
88 +
|
|
|
86 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 1 obs hidden.
CITRAL
KAPLAN-MEIER SURVIVAL CURVES
UNTREAT CONTROL = 1
VEHICLE CONTROL = 2
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 +1 1 2
|
|
|
97.96 + 2 2
|
|
|
95.92 + 2 2
|
P |
E |
R 93.88 + 1 1 22
C |
E |
N |
T 91.84 + 2 2
|
S |
U |
R 89.80 + 1 1 22
V |
I |
V |
A 87.76 + 1 1 2 2
L |
|
|
85.71 + 1 12
|
|
|
83.67 + 121 2
|
|
|
81.63 + 1 1
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.