TDMS Study 60968-02 Pathology Tables
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0078-84-2
Lock Date: 05/12/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 6| 7| 7| 0| 7| 0| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 0| 9| 3| 4| 2| 4| 3| 3| 9| 3| 2| 7| 3| 6| 3| 3| 3| 8| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 5| 6| 3| 6| 5| 7| 1| 7| 3| 6| 7| 9| 7| 7| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X|
Eosinophilic Focus | X 3 X |
Necrosis | |
Tension Lipidosis | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Basophilic Focus | |
Cyst | 4 |
Inflammation, Chronic Active | |
Lipomatosis | 2 4 |
Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Degeneration, Fatty | |
Hyperplasia | 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 6| 7| 7| 0| 7| 0| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 0| 9| 3| 4| 2| 4| 3| 3| 9| 3| 2| 7| 3| 6| 3| 3| 3| 8| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 5| 6| 3| 6| 5| 7| 1| 7| 3| 6| 7| 9| 7| 7| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M I + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 3 3 2 3 3|
Pars Intermedia, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 1 1 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 1 1 1|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + M + M M + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M M + + + + + M + M + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + A + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + M + + + + + M M + + + M + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 3 2 4 3 4 4 4 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + M + + + + M + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 6| 7| 7| 6| 7| 7| 0| 7| 0| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 0| 9| 3| 4| 2| 4| 3| 3| 9| 3| 2| 7| 3| 6| 3| 3| 3| 8| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 5| 6| 3| 6| 5| 7| 1| 7| 3| 6| 7| 9| 7| 7| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | 3 |
Hemorrhage | |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Hyperplasia | 3 |
Interstitium, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Olfactory Epithelium, Degeneration | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Cyst | 2 |
Infarct | 2 |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 3 2 3 1|
Pelvis, Inflammation, Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 1| 3| 3| 9| 4| 1| |
| 7| 6| 5| 5| 5| 0| 7| 9| 3| 7| 7| 7| 3| 6| 5| 6| 6| 6| 7| 1| 6| 6| 5| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X | 1 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X | 6 3.0|
Necrosis | 4 3 4 1 | 4 3.0|
Tension Lipidosis | X X X | 3 |
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Fat, Necrosis | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Basophilic Focus | X | 1 |
Cyst | 4 | 2 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Lipomatosis | 4 3 | 4 3.3|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2| 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 | 9 1.1|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 1| 3| 3| 9| 4| 1| |
| 7| 6| 5| 5| 5| 0| 7| 9| 3| 7| 7| 7| 3| 6| 5| 6| 6| 6| 7| 1| 6| 6| 5| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty | 2 1 | 2 1.5|
Hyperplasia | 1 1 2 | 5 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 5 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + M + + M + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 2 3 3 1 1 2 2 3 2 2 | 19 2.3|
Pars Intermedia, Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 2 3 2 1 2 | 18 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + M + + + + I + M + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 1 2 1 3 2 | 13 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 1 | 2 2.0|
Hydrometra | 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + M + + + + + + M + + + + + + + + M +| 42 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + + M M M + + + + + M + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + M M M + + M + + + + M + + + + + + +| 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Hematopoietic Cell Proliferation | 3 | 11 3.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M M + + + + + M + + + + + + + + M +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 1| 3| 3| 9| 4| 1| |
| 7| 6| 5| 5| 5| 0| 7| 9| 3| 7| 7| 7| 3| 6| 5| 6| 6| 6| 7| 1| 6| 6| 5| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Chronic | | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 3 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 2 1.0|
Bronchiole, Hyperplasia | | 1 3.0|
Interstitium, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Olfactory Epithelium, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 2 3.0|
Cyst | | 1 2.0|
Infarct | | 1 2.0|
Nephropathy | 3 1 1 2 1 2 1 2 1| 23 1.5|
Pelvis, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 3| 3| 3| 3| 1| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3|
| 7| 3| 2| 6| 6| 1| 7| 1| 6| 6| 1| 2| 7| 6| 6| 7| 6| 6| 5| 3| 1| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M A + + + A + A + + + + + + + + + + + A + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + A + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + A + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | 2 |
Eosinophilic Focus | X X X X X X|
Hematopoietic Cell Proliferation | |
Necrosis | 2 |
Thrombosis | |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + +|
Fat, Necrosis | 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Cyst | |
Lipomatosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 3| 3| 3| 3| 1| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3|
| 7| 3| 2| 6| 6| 1| 7| 1| 6| 6| 1| 2| 7| 6| 6| 7| 6| 6| 5| 3| 1| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + M + M + + + + + I + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 2 3 4 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + M M M + + + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + M + M + + + + + + + + M + M M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + M + + + + + + + M + M + + + + + + + M M M|
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 3| 3| 3| 3| 1| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3|
| 7| 3| 2| 6| 6| 1| 7| 1| 6| 6| 1| 2| 7| 6| 6| 7| 6| 6| 5| 3| 1| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Thrombosis | |
Olfactory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Infarct | |
Metaplasia, Osseous | 3 |
Mineralization | |
Nephropathy | 1 1 2 2 3 1 1 1 1 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 6| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 1| 3| 3| 2| 3| 3| 6| 2| 3| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 8| 3| 2| |
| 5| 6| 5| 1| 6| 6| 1| 7| 6| 3| 7| 5| 7| 5| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + + + + + +| 44 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X | 3 |
Cyst | | 1 2.0|
Eosinophilic Focus | X | 7 |
Hematopoietic Cell Proliferation | 3| 1 3.0|
Necrosis | 2 3 | 3 2.3|
Thrombosis | 3 | 1 3.0|
Centrilobular, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Lipomatosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 2 | 12 1.2|
Artery, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | | 2 1.5|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 6| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 1| 3| 3| 2| 3| 3| 6| 2| 3| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 8| 3| 2| |
| 5| 6| 5| 1| 6| 6| 1| 7| 6| 3| 7| 5| 7| 5| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + M + + + + + M + + + M + M + + M| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 3 2 3 2 3 3 2 2 1 3| 23 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 2 2 1 2 1 2 2 2 1 1| 26 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M M + I + + + + + + M + M + + + + + + M + M| 39 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + I + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 1 2 2 2 2 3 2 | 15 2.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 2 3 | 4 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + M M + M + M + + + + + + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + M + + + + + + + + M + + M M + + + +| 38 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M M + + + M + +| 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 4 3 2 2 4 2 3 3 | 11 3.1|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + M + M + + + + + M + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fracture | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 6| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 1| 3| 3| 2| 3| 3| 6| 2| 3| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 8| 3| 2| |
| 5| 6| 5| 1| 6| 6| 1| 7| 6| 3| 7| 5| 7| 5| 7| 6| 6| 7| 7| 7| 5| 5| 6| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Thrombosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 2 | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 | 1 3.0|
Thrombosis | 4 | 1 4.0|
Olfactory Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Infarct | 2 2 | 2 2.0|
Metaplasia, Osseous | | 1 3.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 1 1 1 2 4 1 3 1 3 1 1| 20 1.6|
Renal Tubule, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 6| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3|
| 1| 7| 6| 6| 6| 5| 1| 7| 4| 6| 6| 6| 7| 6| 6| 7| 5| 3| 7| 9| 6| 5| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A M + + + + A M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Clear Cell Focus | |
Cyst | 2 |
Eosinophilic Focus | X X |
Mixed Cell Focus | X |
Necrosis | |
Tension Lipidosis | |
Centrilobular, Necrosis | 3 1 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2|
Inflammation, Chronic Active | |
Lipomatosis | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hypertrophy | 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + + + M M + + + + + M M + + + M +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 6| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3|
| 1| 7| 6| 6| 6| 5| 1| 7| 4| 6| 6| 6| 7| 6| 6| 7| 5| 3| 7| 9| 6| 5| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 3 2 2 2 1 2 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 3 2|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hydrometra | 3 3 4|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + M M M + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + M M + + + + + + + + + M M + M + + M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 3 4 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | M + + + M M + + + + + + M + + + + + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Angiectasis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 6| 1| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 3| 3|
| 1| 7| 6| 6| 6| 5| 1| 7| 4| 6| 6| 6| 7| 6| 6| 7| 5| 3| 7| 9| 6| 5| 6| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 2 1 |
Olfactory Epithelium, Necrosis | 4 |
Respiratory Epithelium, Necrosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Metaplasia, Osseous | 2 1 |
Mineralization | 2 |
Nephropathy | 1 1 1 2 1 1 1 1 1 1|
Pelvis, Dilatation | |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 3| |
| 7| 7| 6| 6| 3| 5| 5| 7| 7| 7| 6| 6| 6| 6| 7| 3| 5| 6| 5| 6| 1| 5| 6| 4| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | X X | 2 |
Clear Cell Focus | X X | 2 |
Cyst | | 1 2.0|
Eosinophilic Focus | X X X | 5 |
Mixed Cell Focus | | 1 |
Necrosis | 1 | 1 1.0|
Tension Lipidosis | X X | 2 |
Centrilobular, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Lipomatosis | 3 3 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 1 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 3 | 1 3.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 3| |
| 7| 7| 6| 6| 3| 5| 5| 7| 7| 7| 6| 6| 6| 6| 7| 3| 5| 6| 5| 6| 1| 5| 6| 4| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2| 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + M M + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 1 2 2 2 1 3 2 1 3 3 2 3 1 1| 23 1.9|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 2 1 2 2 1 1 1 3 1| 24 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + M M + + + + + + + M + + M + + + M + + + +| 40 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3| 2 2.5|
Cyst | 2 1 3 3 3 3 4 2 2 2 2 | 14 2.4|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hydrometra | 3 3 4 | 6 3.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Lumbar, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + M + + M + + + + M + + + M +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M M| 47 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + + + + + + + + + + + + + + M M M +| 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 2 3 4 3 | 11 3.3|
Hyperplasia, Lymphoid | 3 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + M + + + + + + + + + M +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 3| |
| 7| 7| 6| 6| 3| 5| 5| 7| 7| 7| 6| 6| 6| 6| 7| 3| 5| 6| 5| 6| 1| 5| 6| 4| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Angiectasis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 1 2.0|
Olfactory Epithelium, Degeneration | 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 | 27 1.1|
Olfactory Epithelium, Necrosis | 2 | 2 3.0|
Respiratory Epithelium, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | 2 | 1 2.0|
Metaplasia, Osseous | 1 2 | 4 1.5|
Mineralization | 1 | 2 1.5|
Nephropathy | 1 1 1 2 1 | 15 1.1|
Pelvis, Dilatation | 4 | 1 4.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 5| 7| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 3| |
| 7| 7| 6| 6| 3| 5| 5| 7| 7| 7| 6| 6| 6| 6| 7| 3| 5| 6| 5| 6| 1| 5| 6| 4| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 3| 5| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3|
| 2| 1| 7| 6| 2| 7| 5| 5| 5| 6| 7| 6| 3| 7| 6| 3| 7| 5| 7| 7| 3| 6| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Hypertrophy | |
Inflammation, Chronic Active | |
Lipomatosis | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | 1 1 2|
Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 |
Hyperplasia | |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 3| 5| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3|
| 2| 1| 7| 6| 2| 7| 5| 5| 5| 6| 7| 6| 3| 7| 6| 3| 7| 5| 7| 7| 3| 6| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 3 |
Pars Intermedia, Hypertrophy | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 1 3 2 2 1 2 1 3 2 1 1 2 2 1 1 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + M + + + + + + M + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 4 1 2 1 4 1 3 2|
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 3 3 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + M + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + I + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + + M + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 2 3 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 3| 5| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3|
| 2| 1| 7| 6| 2| 7| 5| 5| 5| 6| 7| 6| 3| 7| 6| 3| 7| 5| 7| 7| 3| 6| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Hyperplasia | 1 |
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | 2 2 2 1 1 2 1 2 2 2 2 1 2 2 2 2 1 2 1 2 1 1 1 1|
Olfactory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Mineralization | |
Lens, Mineralization | 3 |
__________________________________________________________________________|
Harderian Gland | +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 2 1 1 1 1 1 2 2 2 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| |
| 5| 5| 7| 5| 6| 2| 1| 6| 5| 5| 6| 6| 7| 6| 6| 6| 7| 6| 7| 3| 6| 6| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + + M + + +| 47 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X| 3 |
Eosinophilic Focus | X X X | 4 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | 4 | 1 4.0|
Hypertrophy | 1 | 1 1.0|
Inflammation, Chronic Active | 2 3 | 2 2.5|
Lipomatosis | 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Hyperplasia, Squamous | | 3 1.3|
Inflammation, Chronic Active | 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| |
| 5| 5| 7| 5| 6| 2| 1| 6| 5| 5| 6| 6| 7| 6| 6| 6| 7| 6| 7| 3| 6| 6| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M M + + + M + + M + M + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 1 2 2 2 2 2| 17 2.1|
Pars Intermedia, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 3 2 1 1 2 2 1 1 1 2 | 32 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + M M + + + + + M + I + + + + + M + + M + +| 40 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 3 3 4 4 1 | 18 2.5|
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hydrometra | 2 3 3 3 | 7 2.9|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Lumbar, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + M + + + + + + + M| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + M + + + + + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M + + M + + M + + M + + M + + M + + M + +| 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 4 4 | 9 3.1|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + + + + + + + + + + M + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 8| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| |
| 5| 5| 7| 5| 6| 2| 1| 6| 5| 5| 6| 6| 7| 6| 6| 6| 7| 6| 7| 3| 6| 6| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Subcutaneous Tissue, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Hyperplasia | | 1 1.0|
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration | 2 2 1 2 2 1 2 2 1 2 2 1 1 2 2 1 1 1 2 1 1 1 2 2 2| 49 1.6|
Olfactory Epithelium, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cornea, Mineralization | 3 3 | 2 3.0|
Lens, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 1 | 2 1.5|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 3 | 20 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 4| 5| 3| 4| 4| 3| 5| 3| 3| 4| 3| 3| 5| 5| 4| 4| 3| 3| 3| 4| 3| 9| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + A + + +|
Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X 3 |
Clear Cell Focus | |
Eosinophilic Focus | X X X |
Infarct, Focal | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic Active | 2 |
Lipomatosis | 1 |
Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 3 2 2 1 2 2 2 |
Hypertrophy | 2 2 1 2 1 2 1 1 1 1 1 1 1 2 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 4| 5| 3| 4| 4| 3| 5| 3| 3| 4| 3| 3| 5| 5| 4| 4| 3| 3| 3| 4| 3| 9| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 1 1 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + M + + + + + M M + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M M + + + + M + M + M + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M M M + M M + M + M + M + M M M M M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Prepuce, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 4| 5| 3| 4| 4| 3| 5| 3| 3| 4| 3| 3| 5| 5| 4| 4| 3| 3| 3| 4| 3| 9| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Epiglottis, Hyperplasia | |
Epiglottis, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 3 |
Artery, Mediastinum, Mineralization | 3 |
Bronchiole, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2|
Infarct | 2 2 |
Mineralization | 2 |
Nephropathy | 3 1 2 2 2 3 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
Pelvis, Inflammation, Acute | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mineralization | 2 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 8| 3| |
| 4| 9| 9| 3| 3| 3| 4| 4| 5| 3| 4| 4| 3| 4| 0| 3| 4| 6| 3| 3| 9| 5| 4| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X | 4 3.0|
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | | 3 |
Infarct, Focal | 4 | 1 4.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Lipomatosis | 1 | 2 1.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 | 14 2.0|
Hypertrophy | 2 2 1 2 1 2 2 1 2 1 1 2 2 2 2 | 32 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 8| 3| |
| 4| 9| 9| 3| 3| 3| 4| 4| 5| 3| 4| 4| 3| 4| 0| 3| 4| 6| 3| 3| 9| 5| 4| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + + + + + + + M I + M + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1| 11 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 2 4| 7 2.9|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + + M M + + M + M M + + + + + + + M +| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M M + M + M + + + M M + M M M M + + M M M M| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + + + + + + + + + + + M M M + + M + + + +| 29 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 3 2 3 | 7 2.6|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + + + M M M + + + M + M + M + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 3| 8| 3| |
| 4| 9| 9| 3| 3| 3| 4| 4| 5| 3| 4| 4| 3| 4| 0| 3| 4| 6| 3| 3| 9| 5| 4| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Prepuce, Inflammation, Acute | 3 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Hyperplasia | 1 | 1 1.0|
Epiglottis, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Pigmentation | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 3 | 3 2.3|
Artery, Mediastinum, Mineralization | | 1 3.0|
Bronchiole, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Hyperplasia | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 2.0|
Infarct | | 2 2.0|
Mineralization | | 1 2.0|
Nephropathy | 2 2 3 2 2 2 2 1 2 1 2 2 3 2 2 2 2 1 2 1 2 2 1| 45 1.9|
Pelvis, Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 7| 3| 8| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 0| 4| 0| 5| 3| 5| 4| 4| 4| 4| 5| 4| 5| 3| 3| 3| 4| 5| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + A + M + + + + + + + + A + + + + + + + + +|
Hyperplasia | 1 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X|
Mixed Cell Focus | X|
Necrosis | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | 3 |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lipomatosis | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2 2 2 2 |
Hypertrophy | 1 2 1 2 2 1 1 2 1 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M + + + + + + M + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 7| 3| 8| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 0| 4| 0| 5| 3| 5| 4| 4| 4| 4| 5| 4| 5| 3| 3| 3| 4| 5| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 3 3 3 4 |
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + M M + + M + + + M + + M + + M + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M + + M + M + M + + M M + + M M M + M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M M + + + + + M M + M M M + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + M + + + M + + + + + + + M M M M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Necrosis | |
Prepuce, Inflammation, Acute | 3 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 8| 7| 3| 8| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 0| 4| 0| 5| 3| 5| 4| 4| 4| 4| 5| 4| 5| 3| 3| 3| 4| 5| 4| 3| 4| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Epiglottis, Metaplasia, Squamous | |
Glands, Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mediastinum, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Infarct | |
Mineralization | |
Nephropathy | 1 1 1 1 1 1 1 2 2 1 2 2 2 2 1 3 1 1 2 1 2 1|
Pelvis, Inflammation, Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 1| |
| 5| 4| 3| 4| 5| 2| 5| 4| 4| 3| 4| 4| 5| 5| 4| 3| 3| 2| 4| 4| 4| 4| 9| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + M + + M +| 43 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X | 8 |
Clear Cell Focus | X X X X X X | 7 |
Eosinophilic Focus | X X X | 6 |
Mixed Cell Focus | X | 2 |
Necrosis | | 1 1.0|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Artery, Inflammation | | 1 3.0|
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lipomatosis | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Developmental Malformation | X X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 2 1 2 1 1 1 2 1 1 1 1| 30 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 2 1 2 2 2 2 2 2 1| 21 1.8|
Hypertrophy | 2 1 1 1 2 2 2 2 2 | 21 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 1| |
| 5| 4| 3| 4| 5| 2| 5| 4| 4| 3| 4| 4| 5| 5| 4| 3| 3| 2| 4| 4| 4| 4| 9| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + M M + + M + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + M M + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 2 1 1 1 1 2 | 11 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 4 | 9 3.3|
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M M + + + M M + + M M + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M M + M + + + M + M M M + + M + + + + + M + M| 25 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + M + M + + + M + + + M + + + M M + M| 34 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 | 7 2.6|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + + + M + M + + + + M + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 2.0|
Necrosis | 2 | 1 2.0|
Prepuce, Inflammation, Acute | 3 | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 1| |
| 5| 4| 3| 4| 5| 2| 5| 4| 4| 3| 4| 4| 5| 5| 4| 3| 3| 2| 4| 4| 4| 4| 9| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3| 1 3.0|
Epiglottis, Metaplasia, Squamous | 1 | 1 1.0|
Glands, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3| 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.3|
Artery, Mediastinum, Mineralization | 2| 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 3 1.7|
Infarct | 1 | 1 1.0|
Mineralization | 2| 1 2.0|
Nephropathy | 1 4 1 2 1 2 2 3 2 1 1 2 1 1 1 1 1 1 2 2 2 2 2 3| 46 1.6|
Pelvis, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 2| 3|
| 2| 3| 1| 5| 4| 4| 4| 3| 3| 3| 3| 9| 3| 4| 4| 5| 0| 4| 3| 9| 4| 5| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M A + + + + + + M + + + M + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X |
Degeneration, Fatty | |
Eosinophilic Focus | |
Infarct, Focal | 4 |
Necrosis | |
Tension Lipidosis | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 1 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Lipomatosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Artery, Inflammation | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 |
Mineralization | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 2 2 2 2 2 |
Hypertrophy | 1 2 2 2 2 2 1 1 2 2 2 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 2| 3|
| 2| 3| 1| 5| 4| 4| 4| 3| 3| 3| 3| 9| 3| 4| 4| 5| 0| 4| 3| 9| 4| 5| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
Cyst | 3 2 4 2 2 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Prostate | + + A + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + + + + + M + M + + M + + M M M + M M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M M + + + M + + M + + M + M + M + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + + M M M + M + + M M + + M M + + + + M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + M + + + + + +|
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 |
Prepuce, Inflammation, Acute | 3 3 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 2| 3|
| 2| 3| 1| 5| 4| 4| 4| 3| 3| 3| 3| 9| 3| 4| 4| 5| 0| 4| 3| 9| 4| 5| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Hyperplasia | 1 |
Epiglottis, Metaplasia, Squamous | 1 |
Glands, Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Infarct | 3 |
Mineralization | |
Nephropathy | 1 2 2 2 2 2 2 2 1 4 2 2 2 2 2 2 2 2 1 1|
Pelvis, Dilatation | 3 |
Pelvis, Inflammation, Acute | 2 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 4| 3| 6| 3| 3| 3| 2| 3| 1| 3| 7| 3| 3| 3| 3| 2| 3| |
| 3| 4| 3| 3| 3| 3| 0| 3| 8| 4| 0| 3| 4| 5| 2| 3| 1| 3| 2| 3| 4| 3| 3| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + M A + M + + A + + + + + +| 42 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X| 3 |
Clear Cell Focus | | 3 |
Degeneration, Fatty | 1 | 1 1.0|
Eosinophilic Focus | X X X| 3 |
Infarct, Focal | 4 | 2 4.0|
Necrosis | 3 | 1 3.0|
Tension Lipidosis | X | 1 |
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis | | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Lipomatosis | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 2 1.0|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 | 26 1.1|
Mineralization | 2 | 1 2.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 4| 3| 6| 3| 3| 3| 2| 3| 1| 3| 7| 3| 3| 3| 3| 2| 3| |
| 3| 4| 3| 3| 3| 3| 0| 3| 8| 4| 0| 3| 4| 5| 2| 3| 1| 3| 2| 3| 4| 3| 3| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 1 2 1 2 2| 18 1.9|
Hypertrophy | 1 2 2 2 2 2 1 1 2 1 1 1| 26 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + M + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 2 1 2 1| 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 6 2.5|
Inflammation, Chronic Active | 4 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M + + + + + + + + + M + + + + + + M M + M| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + M + M + + + + M + + + + M| 36 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M M + + M M M M + M + + M + + + M + + +| 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 4 3 2| 8 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 4| 3| 6| 3| 3| 3| 2| 3| 1| 3| 7| 3| 3| 3| 3| 2| 3| |
| 3| 4| 3| 3| 3| 3| 0| 3| 8| 4| 0| 3| 4| 5| 2| 3| 1| 3| 2| 3| 4| 3| 3| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + M + M + M + + + + + + + M + + + + + + + + + +| 42 |
Artery, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 3.0|
Prepuce, Inflammation, Acute | 1 4| 4 2.8|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Hyperplasia | | 1 1.0|
Epiglottis, Metaplasia, Squamous | | 1 1.0|
Glands, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2| 1 2.0|
Olfactory Epithelium, Degeneration | 1 1 1 2 1 1| 11 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 4| 3| 6| 3| 3| 3| 2| 3| 1| 3| 7| 3| 3| 3| 3| 2| 3| |
| 3| 4| 3| 3| 3| 3| 0| 3| 8| 4| 0| 3| 4| 5| 2| 3| 1| 3| 2| 3| 4| 3| 3| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Infarct | | 1 3.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 2 1 2 2 2 2 1 1 1 1 1 1 1 2 2 2 2 1 1 1 1 2 1 3| 44 1.7|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Inflammation, Acute | 3 | 2 2.5|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Inflammation, Chronic Active | 2 | 2 1.5|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 3| 5| 9| 3| 3| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 8| 3| 3| 3| 8| 7| 4| 4| 4| 9| 9| 5| 5| 3| 4| 3| 3| 3| 0| 5| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X |
Cyst | |
Eosinophilic Focus | X X |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic Active | |
Lipomatosis | 4 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 2 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 1 2 2 2 |
Hypertrophy | 2 1 2 2 2 1 2 2 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + I + + + + + + M + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 2 1 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 3| 5| 9| 3| 3| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 8| 3| 3| 3| 8| 7| 4| 4| 4| 9| 9| 5| 5| 3| 4| 3| 3| 3| 0| 5| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 |
Inflammation, Chronic Active | 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + I + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + M + M + + + M + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M + M + + + + M M + M + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + M + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + M M + M + + M M + M + M + + M + M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + M M M M + M + + + + M M + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 1 |
Glands, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 2| 3| 5| 9| 3| 3| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 8| 3| 3| 3| 8| 7| 4| 4| 4| 9| 9| 5| 5| 3| 4| 3| 3| 3| 0| 5| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 1 2 1 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1 |
Olfactory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 2 2 |
Mineralization | 2 |
Necrosis | 2 |
Nephropathy | 1 2 2 2 1 1 1 1 2 2 1 1 2 2 2 2 2 1 2 2 2 2|
Artery, Inflammation | |
Pelvis, Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 5| 7| 7| |
DAY ON TEST | 7| 3| 3| 5| 3| 3| 6| 3| 9| 7| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 1| 4| 0| 3| |
| 9| 4| 5| 3| 5| 4| 5| 4| 0| 1| 3| 4| 5| 3| 3| 3| 3| 1| 9| 3| 5| 6| 7| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M M + + + + A A + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 4 |
Clear Cell Focus | | 2 |
Cyst | 3 | 1 3.0|
Eosinophilic Focus | X | 3 |
Mixed Cell Focus | X | 1 |
Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Lipomatosis | 1 2 | 5 2.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 2 2 2 1 2 2 1 2 | 27 1.3|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 2 2 1 2 2 2 1 | 18 1.8|
Hypertrophy | 2 1 2 1 1 2 1 2 2 2 2 1 1 1| 26 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M + + + + + + + + + + + M + + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 5| 7| 7| |
DAY ON TEST | 7| 3| 3| 5| 3| 3| 6| 3| 9| 7| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 1| 4| 0| 3| |
| 9| 4| 5| 3| 5| 4| 5| 4| 0| 1| 3| 4| 5| 3| 3| 3| 3| 1| 9| 3| 5| 6| 7| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 2 3 1| 12 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 4 2.5|
Inflammation, Chronic Active | 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + I + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M M + + + M M + + M + M M M + + + M + +| 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + M M M M + M + M + + + + M + M + + M M| 31 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + M M + + + + + + M + M| 34 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 2 3 3 3 | 9 3.2|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + M + + + + M + + M M + + + M + + + + + + +| 36 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Acute | 3 4 4 4 4 4 4 4 | 9 3.9|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 60968-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 09/23/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:11:49
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 5| 7| 7| |
DAY ON TEST | 7| 3| 3| 5| 3| 3| 6| 3| 9| 7| 3| 3| 3| 3| 3| 5| 3| 9| 9| 3| 3| 1| 4| 0| 3| |
| 9| 4| 5| 3| 5| 4| 5| 4| 0| 1| 3| 4| 5| 3| 3| 3| 3| 1| 9| 3| 5| 6| 7| 9| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epiglottis, Metaplasia, Squamous | 1 1 | 3 1.0|
Glands, Inflammation, Suppurative | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 | 3 1.3|
Olfactory Epithelium, Degeneration | 1 2 1 2 1 2 1 1 1 1 2 1 1 1 2 2 1 2 1 2 2 | 45 1.4|
Olfactory Epithelium, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infarct | 2 2 2 | 5 2.0|
Mineralization | | 1 2.0|
Necrosis | | 1 2.0|
Nephropathy | 2 2 2 4 2 2 2 2 1 2 2 2 2 2 1 2 1 2 2 2 2 1 2| 45 1.8|
Artery, Inflammation | 2 2 | 2 2.0|
Pelvis, Inflammation, Acute | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 4 4 | 3 3.3|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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