TDMS Study 60968-01 Pathology Tables
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 0078-84-2
Lock Date: 06/01/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 6| 4| 6| 7| 7| 7| 4| 7| 5| 6| 7| 4|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 4| 2| 9| 9| 3| 2| 0| 7| 3| 3| 3| 4| 3| 8| 9| 3| 4|
| 5| 7| 5| 5| 5| 4| 4| 5| 7| 0| 6| 0| 4| 3| 0| 9| 5| 5| 5| 7| 5| 0| 5| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 2 2 |
Vacuolization Cytoplasmic | 4 3 4 |
Hepatocyte, Hyperplasia | |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
Fibrosis | |
Hyperplasia | |
Inflammation, Chronic | |
Pharyngeal, Hyperplasia | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | 3 3 3|
Inflammation, Suppurative | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 6| 4| 6| 7| 7| 7| 4| 7| 5| 6| 7| 4|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 4| 2| 9| 9| 3| 2| 0| 7| 3| 3| 3| 4| 3| 8| 9| 3| 4|
| 5| 7| 5| 5| 5| 4| 4| 5| 7| 0| 6| 0| 4| 3| 0| 9| 5| 5| 5| 7| 5| 0| 5| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | 2 1 3 2 1 2 1 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + M + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 3 |
Pars Distalis, Hyperplasia | 2 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 4 3 4 |
Hyperplasia | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 6| 4| 6| 7| 7| 7| 4| 7| 5| 6| 7| 4|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 4| 2| 9| 9| 3| 2| 0| 7| 3| 3| 3| 4| 3| 8| 9| 3| 4|
| 5| 7| 5| 5| 5| 4| 4| 5| 7| 0| 6| 0| 4| 3| 0| 9| 5| 5| 5| 7| 5| 0| 5| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X X X |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | |
Inflammation, Granulomatous | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Ventricle, Hydrocephalus | 3 3 2 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X|
Epiglottis, Metaplasia, Squamous | 1 |
Epithelium, Hyperplasia | 2 2 3 |
Epithelium, Metaplasia, Squamous | 1 2 |
Glands, Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 3|
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Fibrosis | 2 2 |
Alveolar Epithelium, Foreign Body | X |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 2 1 1 |
Bronchiole, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 6| 4| 6| 7| 7| 7| 4| 7| 5| 6| 7| 4|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 4| 2| 9| 9| 3| 2| 0| 7| 3| 3| 3| 4| 3| 8| 9| 3| 4|
| 5| 7| 5| 5| 5| 4| 4| 5| 7| 0| 6| 0| 4| 3| 0| 9| 5| 5| 5| 7| 5| 0| 5| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Inflammation, Suppurative | 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Pleura | |
Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 1 1 3 1 2 2 1 2 1 1 1 2 2 1 1|
Medulla, Renal Tubule, Cyst | |
Renal Tubule, Mineralization | 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 0| 6| 5| 6| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 5| 9| 8| 2| 3| 6| 3| 2| 1| 3| |
| 8| 4| 7| 4| 4| 4| 5| 4| 5| 8| 5| 7| 5| 4| 4| 6| 2| 0| 5| 4| 1| 4| 5| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Diverticulum | | 1 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2| 1 2.0|
Basophilic Focus | X | 2 |
Basophilic Focus, Multiple | X | 3 |
Clear Cell Focus | X X | 4 |
Clear Cell Focus, Multiple | X X X X | 5 |
Hepatodiaphragmatic Nodule | X X X | 6 |
Inflammation, Granulomatous | | 2 2.0|
Vacuolization Cytoplasmic | 4 3 | 5 3.6|
Hepatocyte, Hyperplasia | 3 | 1 3.0|
Serosa, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 7 |
Fat, Necrosis | 4 3 3| 5 3.2|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 4 |
Fibrosis | 4 | 1 4.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Pharyngeal, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia | 3 2 | 5 2.8|
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 0| 6| 5| 6| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 5| 9| 8| 2| 3| 6| 3| 2| 1| 3| |
| 8| 4| 7| 4| 4| 4| 5| 4| 5| 8| 5| 7| 5| 4| 4| 6| 2| 0| 5| 4| 1| 4| 5| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | A + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Atrium, Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
Vacuolization Cytoplasmic | 4 3 2 | 12 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + + + + + + + M + + + + + + + + +| 48 |
Cyst | 3 3 | 6 2.8|
Pars Distalis, Hyperplasia | 2 3 4 3 | 9 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 1 1| 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 4 3 3 3| 7 3.4|
Hyperplasia | 4 3| 2 3.5|
Inflammation, Suppurative | 3 | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Uterus | A + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Endometrium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 0| 6| 5| 6| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 5| 9| 8| 2| 3| 6| 3| 2| 1| 3| |
| 8| 4| 7| 4| 4| 4| 5| 4| 5| 8| 5| 7| 5| 4| 4| 6| 2| 0| 5| 4| 1| 4| 5| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + A + + + + + + + M + + + + + + + + M + + + + +| 45 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | | 4 |
Fibrosis | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 4 | 1 4.0|
Hyperplasia | 4 | 1 4.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 2 | 4 2.8|
Ventricle, Hydrocephalus | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 0| 6| 5| 6| 7| 5| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 4| 3| 3| 3| 5| 9| 8| 2| 3| 6| 3| 2| 1| 3| |
| 8| 4| 7| 4| 4| 4| 5| 4| 5| 8| 5| 7| 5| 4| 4| 6| 2| 0| 5| 4| 1| 4| 5| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | X X X X| 6 |
Epiglottis, Metaplasia, Squamous | 2 | 2 1.5|
Epithelium, Hyperplasia | 2 2 | 5 2.2|
Epithelium, Metaplasia, Squamous | 2 2 3| 5 2.0|
Glands, Inflammation, Suppurative | 2 2 4| 5 3.0|
__________________________________________________________________________|____________|
Lung | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 3 2.0|
Inflammation, Granulomatous | | 1 1.0|
Alveolar Epithelium, Fibrosis | 3 3| 4 2.5|
Alveolar Epithelium, Foreign Body | | 1 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 1 1 3 2 2 4 1| 10 1.8|
Bronchiole, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X X | 2 |
Inflammation, Suppurative | | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 1| 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pleura | +| 1 |
Inflammation | 3| 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 3 1 2 3 1 1 2 3 1 1 2 2 1 1 1 1 4 2| 35 1.6|
Medulla, Renal Tubule, Cyst | 3 | 1 3.0|
Renal Tubule, Mineralization | | 5 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Transitional Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 3| 1| 2| 3| 6| 0| 9| 3| 8| 3| 3| 3| 0| 3| 7| 3| 4| 5| 3| 8| 0|
| 5| 4| 5| 1| 4| 1| 4| 4| 3| 5| 2| 6| 1| 5| 4| 5| 1| 4| 8| 4| 0| 2| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + A + + + + + + + + A + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + A + + + + + + + + A + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + + + + + + + A + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2|
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + A + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M + + + + + + M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 3| 1| 2| 3| 6| 0| 9| 3| 8| 3| 3| 3| 0| 3| 7| 3| 4| 5| 3| 8| 0|
| 5| 4| 5| 1| 4| 1| 4| 4| 3| 5| 2| 6| 1| 5| 4| 5| 1| 4| 8| 4| 0| 2| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | 4 3 2 3 2 1 3 4 4 |
Hemorrhage | 4 3|
Pars Distalis, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 3 4 |
Hyperplasia | 4 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Angiectasis | |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 3| 1| 2| 3| 6| 0| 9| 3| 8| 3| 3| 3| 0| 3| 7| 3| 4| 5| 3| 8| 0|
| 5| 4| 5| 1| 4| 1| 4| 4| 3| 5| 2| 6| 1| 5| 4| 5| 1| 4| 8| 4| 0| 2| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
Ulcer | 3 |
Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fracture | |
Cranium, Femur, Osteopetrosis | 4 |
Maxilla, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + A + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | 2 |
Necrosis | |
Ventricle, Hydrocephalus | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | |
Glands, Inflammation, Suppurative | 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Fibrosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 4 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 1 2 1 1 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Foreign Body | X X|
Hemorrhage | |
Inflammation, Suppurative | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Mineralization | |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 5| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 3| 1| 2| 3| 6| 0| 9| 3| 8| 3| 3| 3| 0| 3| 7| 3| 4| 5| 3| 8| 0|
| 5| 4| 5| 1| 4| 1| 4| 4| 3| 5| 2| 6| 1| 5| 4| 5| 1| 4| 8| 4| 0| 2| 4| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 1 1 1 1 1 3 2 1 2 1|
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 5| |
DAY ON TEST | 4| 9| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 7| 7| 2| 3| 5| 3| 0| 0| 3| 4| |
| 2| 5| 4| 5| 4| 4| 1| 4| 2| 4| 5| 5| 5| 4| 5| 5| 8| 4| 6| 1| 4| 6| 8| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X| 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Clear Cell Focus | X X X X| 5 |
Clear Cell Focus, Multiple | | 1 |
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X | 6 |
Vacuolization Cytoplasmic | 4 | 2 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 7 |
Artery, Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 3 3 4 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 2 3.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.5|
Ulcer | 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Vacuolization Cytoplasmic | 2 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 5| |
DAY ON TEST | 4| 9| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 7| 7| 2| 3| 5| 3| 0| 0| 3| 4| |
| 2| 5| 4| 5| 4| 4| 1| 4| 2| 4| 5| 5| 5| 4| 5| 5| 8| 4| 6| 1| 4| 6| 8| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 3 1 4 1| 14 2.6|
Hemorrhage | | 2 3.5|
Pars Distalis, Hyperplasia | 2 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 2 2 2 1 | 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 2 4 3 3 | 11 3.3|
Hyperplasia | 3 2 | 4 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Endometrium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | X | 1 |
Angiectasis | 4 | 1 4.0|
Fibrosis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 5| |
DAY ON TEST | 4| 9| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 7| 7| 2| 3| 5| 3| 0| 0| 3| 4| |
| 2| 5| 4| 5| 4| 4| 1| 4| 2| 4| 5| 5| 5| 4| 5| 5| 8| 4| 6| 1| 4| 6| 8| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 4 3.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 3 4 | 3 3.3|
Epidermis, Cyst | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fracture | 4 | 1 4.0|
Cranium, Femur, Osteopetrosis | | 1 4.0|
Maxilla, Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Gliosis | 3 | 1 3.0|
Hemorrhage | 3 | 2 2.5|
Necrosis | 4 | 1 4.0|
Ventricle, Hydrocephalus | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
Epithelium, Metaplasia, Squamous | 2 | 1 2.0|
Glands, Inflammation, Suppurative | 1 1 1 1 | 11 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Fibrosis | 1| 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 1 | 6 2.0|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 2 2 1 1| 10 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 5| |
DAY ON TEST | 4| 9| 3| 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 7| 7| 2| 3| 5| 3| 0| 0| 3| 4| |
| 2| 5| 4| 5| 4| 4| 1| 4| 2| 4| 5| 5| 5| 4| 5| 5| 8| 4| 6| 1| 4| 6| 8| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 2 1.0|
Foreign Body | | 2 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 3 1 | 3 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1 3 1 2 1 1| 11 1.4|
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Mineralization | 2 | 1 2.0|
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 2 2 2 2 1 3 2 2 1 2 3 1 1 1 2 1 1 1 1 | 30 1.6|
Renal Tubule, Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 0| 0| 8| 9| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 8|
| 5| 5| 5| 5| 8| 8| 7| 2| 7| 9| 1| 5| 5| 4| 4| 4| 5| 6| 5| 4| 2| 5| 7| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X |
Clear Cell Focus, Multiple | X |
Hepatodiaphragmatic Nodule | X X X X X X |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
Inflammation, Suppurative | 2 |
Gingival, Inflammation, Suppurative | 4 |
Pharyngeal, Hyperplasia | 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3|
Inflammation, Suppurative | 2 |
Ulcer | 2 2 4 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 2 1 3 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 0| 0| 8| 9| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 8|
| 5| 5| 5| 5| 8| 8| 7| 2| 7| 9| 1| 5| 5| 4| 4| 4| 5| 6| 5| 4| 2| 5| 7| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 3 3 4 |
Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 3 4 |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 3 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 2 |
Hyperplasia | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Cervix, Hypertrophy | |
Endometrium, Hyperplasia | 2 |
Endometrium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 0| 0| 8| 9| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 8|
| 5| 5| 5| 5| 8| 8| 7| 2| 7| 9| 1| 5| 5| 4| 4| 4| 5| 6| 5| 4| 2| 5| 7| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 3 |
Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 4|
Ventricle, Hydrocephalus | 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X 1 X X |
Inflammation, Suppurative | 1 |
Epiglottis, Metaplasia, Squamous | 1 1 |
Epithelium, Metaplasia, Squamous | 1 1 1 |
Glands, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Alveolar Epithelium, Fibrosis | 2 3|
Alveolar Epithelium, Hyperplasia | 3 4 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 1 3 2 1 1 1 2 |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Foreign Body | X X X |
Inflammation, Suppurative | 4 2 |
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 5| 4| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 3| 3| 8| 0| 0| 8| 9| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 8|
| 5| 5| 5| 5| 8| 8| 7| 2| 7| 9| 1| 5| 5| 4| 4| 4| 5| 6| 5| 4| 2| 5| 7| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 1 1 2 1 2 1 1 2 2 2 1 |
Pelvis, Dilatation | 3 |
Renal Tubule, Inflammation, | |
Suppurative | |
Renal Tubule, Mineralization | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 2| 3| 3| 3| 3| 6| 8| 8| 3| 3| 8| 9| 1| 3| 3| 0| 3| 6| 0| 0| |
| 5| 6| 7| 6| 5| 0| 4| 4| 5| 5| 4| 7| 1| 4| 5| 7| 6| 4| 5| 4| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | | 1 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | | 3 |
Clear Cell Focus, Multiple | X X | 3 |
Hepatodiaphragmatic Nodule | X | 7 |
Vacuolization Cytoplasmic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Fat, Necrosis | 3 3 3 3 1 | 6 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Inflammation, Suppurative | | 1 2.0|
Gingival, Inflammation, Suppurative | | 1 4.0|
Pharyngeal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 5 2.8|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 3 | 5 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 2| 3| 3| 3| 3| 6| 8| 8| 3| 3| 8| 9| 1| 3| 3| 0| 3| 6| 0| 0| |
| 5| 6| 7| 6| 5| 0| 4| 4| 5| 5| 4| 7| 1| 4| 5| 7| 6| 4| 5| 4| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 1 | 9 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + M + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M + + + + + + + + + + M + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 1 4 1 1 1 4| 13 2.2|
Hemorrhage | 4| 2 3.0|
Pars Distalis, Hyperplasia | 3 3 4 3 | 6 3.3|
Pars Distalis, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 2 | 9 1.8|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 3 4 3 3 3 4 4 3 | 14 3.1|
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 1 3 | 3 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Cervix, Hypertrophy | 4 | 1 4.0|
Endometrium, Hyperplasia | 3 | 2 2.5|
Endometrium, Metaplasia, Squamous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 2| 3| 3| 3| 3| 6| 8| 8| 3| 3| 8| 9| 1| 3| 3| 0| 3| 6| 0| 0| |
| 5| 6| 7| 6| 5| 0| 4| 4| 5| 5| 4| 7| 1| 4| 5| 7| 6| 4| 5| 4| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | X X | 2 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 1| 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 1 4.0|
Ulcer | | 1 3.0|
Epidermis, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 3| 5 3.4|
Ventricle, Hydrocephalus | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + I + + +| 48 |
Foreign Body | X X | 7 1.0|
Inflammation, Suppurative | 2 1 | 3 1.3|
Epiglottis, Metaplasia, Squamous | 2 1 | 4 1.3|
Epithelium, Metaplasia, Squamous | 1 2 1 | 6 1.2|
Glands, Inflammation, Suppurative | 1 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 4 1.8|
Alveolar Epithelium, Fibrosis | | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2| 3 3.0|
Alveolar Epithelium, Infiltration | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 2| 5| 3| 2| 3| 3| 3| 3| 6| 8| 8| 3| 3| 8| 9| 1| 3| 3| 0| 3| 6| 0| 0| |
| 5| 6| 7| 6| 5| 0| 4| 4| 5| 5| 4| 7| 1| 4| 5| 7| 6| 4| 5| 4| 6| 5| 4| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Cellular, Histiocyte | 2 1 1 2| 11 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 1 2 | 5 1.2|
Foreign Body | X X | 5 |
Inflammation, Suppurative | 2 2 4 | 5 2.8|
Olfactory Epithelium, Degeneration | 1 1 | 2 1.0|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 1 1 1 1 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 1 2 3 1 1 1 2 1 2 2 1 2 2 1 1| 30 1.5|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Renal Tubule, Mineralization | 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6| 6|
DAY ON TEST | 3| 2| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 7| 3| 3| 4|
| 5| 4| 5| 2| 6| 4| 5| 5| 5| 4| 4| 4| 4| 4| 9| 5| 6| 4| 5| 5| 4| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + A + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + A + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + A + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X|
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Vacuolization Cytoplasmic | 3 2 2 2 |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Hyperplasia | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 1 3 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 3 3 1 2 2 4|
Pars Distalis, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6| 6|
DAY ON TEST | 3| 2| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 7| 3| 3| 4|
| 5| 4| 5| 2| 6| 4| 5| 5| 5| 4| 4| 4| 4| 4| 9| 5| 6| 4| 5| 5| 4| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Hyperplasia | 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Cyst | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Epidermis, Cyst | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 4| 7| 6| 6|
DAY ON TEST | 3| 2| 3| 4| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 7| 3| 3| 4|
| 5| 4| 5| 2| 6| 4| 5| 5| 5| 4| 4| 4| 4| 4| 9| 5| 6| 4| 5| 5| 4| 1| 5| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 3 |
Epiglottis, Metaplasia, Squamous | 1 1 2 |
Epithelium, Hyperplasia | 4 |
Epithelium, Metaplasia, Squamous | 2 1 1 3 1 2 |
Glands, Inflammation, Suppurative | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Alveolar Epithelium, Fibrosis | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 2 2 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X |
Inflammation, Suppurative | 1 2 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2|
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2|
Olfactory Epithelium, Degeneration | 1 2 2 1 1 2 2 2 1 1 1 2 1 1 1 2 1 1 1 1 1 1 2 1|
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 3 2 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 3 2 2 2 1 1 2 2 3 2 1 2 1 1 2 1 2 1 2|
Cortex, Necrosis | 2 |
Pelvis, Dilatation | |
Renal Tubule, Degeneration | |
Renal Tubule, Inflammation, | |
Suppurative | 2 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 7| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 4| 3| 4| 3| 6| 3| 6| 3| |
| 1| 3| 5| 1| 1| 5| 4| 5| 4| 5| 4| 5| 5| 4| 5| 4| 6| 6| 4| 1| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X | 3 |
Clear Cell Focus, Multiple | | 2 |
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X | 5 |
Vacuolization Cytoplasmic | 2 3 4 | 7 2.6|
Hepatocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 3 | 4 2.8|
__________________________________________________________________________|____________|
Oral Mucosa | + + | 3 |
Pharyngeal, Hyperplasia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 5 2.4|
Ulcer | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | + | 2 |
Epithelium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 1 2 1 3 2 4 | 11 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 7| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 4| 3| 4| 3| 6| 3| 6| 3| |
| 1| 3| 5| 1| 1| 5| 4| 5| 4| 5| 4| 5| 5| 4| 5| 4| 6| 6| 4| 1| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 | 11 2.7|
Pars Distalis, Hyperplasia | 3 2 | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 1 3 | 6 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Cyst | 4 3 2 3 3 3 4 | 9 3.1|
Hyperplasia | | 1 1.0|
Inflammation, Suppurative | 3 3 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + M + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 4 3.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 7| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 4| 3| 4| 3| 6| 3| 6| 3| |
| 1| 3| 5| 1| 1| 5| 4| 5| 4| 5| 4| 5| 5| 4| 5| 4| 6| 6| 4| 1| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Ventricle, Hydrocephalus | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 4 |
Inflammation, Suppurative | 2 1 1 1 3 | 6 1.8|
Epiglottis, Metaplasia, Squamous | 1 1 1 | 6 1.2|
Epithelium, Hyperplasia | | 1 4.0|
Epithelium, Metaplasia, Squamous | 2 1 1 2 | 10 1.6|
Glands, Inflammation, Suppurative | 1 | 8 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 4 1.8|
Alveolar Epithelium, Fibrosis | | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.3|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 1 2 | 7 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 5 |
Inflammation, Suppurative | 1 2 2 1 3 2 1 3 | 11 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | | 1 2.0|
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2 1 1 2 1 1| 45 1.3|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 1 1 1 2 1 2 1 1 1 3 1 1 1 1 1 1 2 3 1 1| 44 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 7| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 4| 3| 4| 3| 6| 3| 6| 3| |
| 1| 3| 5| 1| 1| 5| 4| 5| 4| 5| 4| 5| 5| 4| 5| 4| 6| 6| 4| 1| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 2 1 1 3 2 1 2 2 1 2 1 2 | 36 1.7|
Cortex, Necrosis | | 1 2.0|
Pelvis, Dilatation | 4 | 1 4.0|
Renal Tubule, Degeneration | 4 | 1 4.0|
Renal Tubule, Inflammation, | | |
Suppurative | | 1 2.0|
Renal Tubule, Mineralization | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 2| 5| 6| 5| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 4| 5| 7| 6| 6| 6|
DAY ON TEST | 8| 5| 5| 4| 2| 5| 7| 0| 3| 3| 3| 0| 3| 3| 6| 0| 7| 2| 8| 3| 8| 3| 0| 1| 3|
| 2| 9| 6| 2| 3| 1| 4| 6| 3| 3| 3| 8| 3| 3| 3| 6| 8| 0| 5| 3| 0| 3| 8| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Vacuolization Cytoplasmic | 3 2 4 3 4 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Degeneration, Cystic | 4 3 |
Hepatocyte, Hyperplasia | 4 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Inflammation, Granulomatous | |
Fat, Necrosis | 3 4 4 4 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 3 |
Hyperplasia | 1 1 1 |
Ulcer | 3 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Vacuolization Cytoplasmic | 3 2 3 |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 2| 5| 6| 5| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 4| 5| 7| 6| 6| 6|
DAY ON TEST | 8| 5| 5| 4| 2| 5| 7| 0| 3| 3| 3| 0| 3| 3| 6| 0| 7| 2| 8| 3| 8| 3| 0| 1| 3|
| 2| 9| 6| 2| 3| 1| 4| 6| 3| 3| 3| 8| 3| 3| 3| 6| 8| 0| 5| 3| 0| 3| 8| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 2 2 2 2 2 3 4 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 3 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | 2 4 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 2 4 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | 3 3 |
Germinal Epithelium, Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 2| 5| 6| 5| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 4| 5| 7| 6| 6| 6|
DAY ON TEST | 8| 5| 5| 4| 2| 5| 7| 0| 3| 3| 3| 0| 3| 3| 6| 0| 7| 2| 8| 3| 8| 3| 0| 1| 3|
| 2| 9| 6| 2| 3| 1| 4| 6| 3| 3| 3| 8| 3| 3| 3| 6| 8| 0| 5| 3| 0| 3| 8| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 4 3 3 3 4 |
Hemorrhage | 3 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 4 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Granulomatous | 2 |
Inflammation, Suppurative | 4 3 4 |
Ulcer | 4 |
Epidermis, Cyst | 4 |
Subcutaneous Tissue, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 4 4 |
Ventricle, Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Epithelium, Hyperplasia | 2 |
Epithelium, Metaplasia, Squamous | 2 |
Glands, Inflammation, Suppurative | 3 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1 2 2 2 |
Alveolar Epithelium, Foreign Body | |
Alveolar Epithelium, Hyperplasia | 3 4 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 2 |
Foreign Body | |
Inflammation, Suppurative | 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 2| 5| 6| 5| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 4| 5| 7| 6| 6| 6|
DAY ON TEST | 8| 5| 5| 4| 2| 5| 7| 0| 3| 3| 3| 0| 3| 3| 6| 0| 7| 2| 8| 3| 8| 3| 0| 1| 3|
| 2| 9| 6| 2| 3| 1| 4| 6| 3| 3| 3| 8| 3| 3| 3| 6| 8| 0| 5| 3| 0| 3| 8| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 2 3 |
Cornea, Mineralization | |
Lens, Mineralization | 4 |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 2 2 4 2 4 2 4 3 2 3 3 3 4 3 4 1 2 3 2 3 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Suppurative | 3 |
Transitional Epithelium, Hyperplasia | 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 6| 6| 6| 6| 5| 7| 6| 7| 4| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 4| 7| 3| 2| 9| 1| 7| 9| 8| 9| 6| 3| 0| 0| 6| 3| 7| 4| 8| 3| 2| 3| 6| 3| 6| |
| 7| 8| 3| 1| 2| 4| 8| 8| 1| 5| 6| 3| 4| 5| 5| 3| 9| 9| 7| 3| 9| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + A + + + + + + + +| 47 |
Parasite Metazoan | X X| 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 3.5|
Clear Cell Focus | X X | 3 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X | 5 |
Vacuolization Cytoplasmic | 3 2 3 2 3 | 10 2.9|
Bile Duct, Hyperplasia | 3 3 3 | 4 2.8|
Hepatocyte, Degeneration, Cystic | | 2 3.5|
Hepatocyte, Hyperplasia | | 1 4.0|
Hepatocyte, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Fat, Inflammation, Granulomatous | 3 | 1 3.0|
Fat, Necrosis | 3 3 4 3 3 | 10 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 1 3 | 9 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 3 3.3|
Hyperplasia | 2 2 | 5 1.4|
Ulcer | 4 | 4 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 | 6 2.0|
Atrium, Thrombosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 6| 6| 6| 6| 5| 7| 6| 7| 4| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 4| 7| 3| 2| 9| 1| 7| 9| 8| 9| 6| 3| 0| 0| 6| 3| 7| 4| 8| 3| 2| 3| 6| 3| 6| |
| 7| 8| 3| 1| 2| 4| 8| 8| 1| 5| 6| 3| 4| 5| 5| 3| 9| 9| 7| 3| 9| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 4 3 2 3 3 1 2 3 3| 20 2.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2 | 3 3.3|
Hemorrhage | 3 | 2 3.5|
Pars Distalis, Hyperplasia | 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 3 2.3|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 2 2 | 2 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 | 3 3.7|
Hyperplasia | 4 3 | 4 3.3|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 4 3 3 4 | 9 3.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 3 | 4 3.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | 3 | 3 3.0|
Germinal Epithelium, Atrophy | 4 3 4 4 4 | 7 3.9|
Interstitial Cell, Hyperplasia | 1 2 3| 7 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 6| 6| 6| 6| 5| 7| 6| 7| 4| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 4| 7| 3| 2| 9| 1| 7| 9| 8| 9| 6| 3| 0| 0| 6| 3| 7| 4| 8| 3| 2| 3| 6| 3| 6| |
| 7| 8| 3| 1| 2| 4| 8| 8| 1| 5| 6| 3| 4| 5| 5| 3| 9| 9| 7| 3| 9| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + M + + + M + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 1 3 3 3 3 | 10 3.0|
Hemorrhage | | 3 3.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 4 | 5 3.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 4 | 2 3.0|
Inflammation, Granulomatous | 3 | 2 2.5|
Inflammation, Suppurative | | 3 3.7|
Ulcer | | 1 4.0|
Epidermis, Cyst | 2 4 4| 4 3.5|
Subcutaneous Tissue, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 4 3.8|
Ventricle, Hydrocephalus | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 4| 6| 6| 6| 6| 6| 6| 5| 7| 6| 7| 4| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 4| 7| 3| 2| 9| 1| 7| 9| 8| 9| 6| 3| 0| 0| 6| 3| 7| 4| 8| 3| 2| 3| 6| 3| 6| |
| 7| 8| 3| 1| 2| 4| 8| 8| 1| 5| 6| 3| 4| 5| 5| 3| 9| 9| 7| 3| 9| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | | 1 2.0|
Epithelium, Metaplasia, Squamous | | 1 2.0|
Glands, Inflammation, Suppurative | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 7 1.6|
Alveolar Epithelium, Foreign Body | X | 1 |
Alveolar Epithelium, Hyperplasia | 2 3 1 | 5 2.6|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 5 1.8|
Foreign Body | X X X X X | 5 |
Inflammation, Suppurative | 3 3 4 2 | 5 2.6|
Respiratory Epithelium, Hyperplasia | 2 2 | 2 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | | 3 3.0|
Cornea, Mineralization | 3 | 1 3.0|
Lens, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 1 3 2 1 3 3 4 3 2 3 1 4 3 4 3 2 3 2 3 2 3 4 1| 47 2.7|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | | 1 |
Inflammation, Suppurative | | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 7| 1| 6| 5| 7|
DAY ON TEST | 3| 1| 3| 2| 4| 0| 1| 0| 3| 6| 1| 7| 3| 7| 8| 9| 6| 3| 3| 1| 3| 8| 6| 8| 0|
| 3| 5| 6| 8| 0| 8| 6| 5| 3| 7| 4| 9| 3| 8| 7| 2| 4| 3| 3| 6| 3| 4| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 2 3 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 4 |
Hepatocyte, Degeneration, Cystic | 2 2 3 4 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Hemorrhage | |
Fat, Inflammation, Granulomatous | 4 |
Fat, Necrosis | 4 3 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
Cyst | 3 |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 3 2 |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 2 |
Inflammation, Suppurative | |
Necrosis | |
Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3|
Ulcer | 3|
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 7| 1| 6| 5| 7|
DAY ON TEST | 3| 1| 3| 2| 4| 0| 1| 0| 3| 6| 1| 7| 3| 7| 8| 9| 6| 3| 3| 1| 3| 8| 6| 8| 0|
| 3| 5| 6| 8| 0| 8| 6| 5| 3| 7| 4| 9| 3| 8| 7| 2| 4| 3| 3| 6| 3| 4| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 2 4 1 2 3 4 2 4 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hemorrhage | 4 4 |
Pars Distalis, Hyperplasia | 3 3 3 2 3 4 3 |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 3 4 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 3 4 2|
Hyperplasia | 3 |
Inflammation, Suppurative | 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 3 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 7| 1| 6| 5| 7|
DAY ON TEST | 3| 1| 3| 2| 4| 0| 1| 0| 3| 6| 1| 7| 3| 7| 8| 9| 6| 3| 3| 1| 3| 8| 6| 8| 0|
| 3| 5| 6| 8| 0| 8| 6| 5| 3| 7| 4| 9| 3| 8| 7| 2| 4| 3| 3| 6| 3| 4| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + +|
Iliac, Ectasia | 4|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Histiocytic | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Angiectasis | 4 |
Fibrosis | 3 2 3 3 3 3 2 3|
Hemorrhage | |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 1 4 3 4 4 4 4 |
Hyperplasia | 3 |
Ulcer | 4 |
Epidermis, Cyst | 3 |
Sebaceous Gland, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrosis | |
Cranium, Inflammation, Granulomatous | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 2 2 4 |
Ventricle, Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 6| 7| 1| 6| 5| 7|
DAY ON TEST | 3| 1| 3| 2| 4| 0| 1| 0| 3| 6| 1| 7| 3| 7| 8| 9| 6| 3| 3| 1| 3| 8| 6| 8| 0|
| 3| 5| 6| 8| 0| 8| 6| 5| 3| 7| 4| 9| 3| 8| 7| 2| 4| 3| 3| 6| 3| 4| 7| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | 1 |
Glands, Inflammation, Suppurative | 1 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Alveolar Epithelium, Fibrosis | 3 2 |
Alveolar Epithelium, Hyperplasia | 2 3 2 3 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 3 3 3 4 2 3 |
Bronchiole, Bronchus, Interstitium, | |
Fibrosis | |
Interstitium, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2|
Foreign Body | X X |
Inflammation, Suppurative | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I + |
Lens, Cataract | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 1 3 2 2 2 2 3 4 2 4 3 3 4 2 2 2 4 2 4 2 1 4|
Cortex, Necrosis | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Suppurative | |
Ulcer | |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 6| 3| 7| 7| 6| 6| 6| 4| 5| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 9| 1| 3| 7| 0| 3| 3| 6| 7| 7| 8| 3| 3| 8| 4| 1| 0| 7| 5| |
| 3| 5| 3| 8| 3| 3| 4| 6| 3| 9| 1| 3| 3| 3| 9| 4| 4| 3| 3| 7| 4| 4| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 2 | 6 2.8|
Basophilic Focus | X | 2 |
Clear Cell Focus | | 2 |
Hepatodiaphragmatic Nodule | X X | 4 |
Vacuolization Cytoplasmic | 4 2 3 4 4 | 6 3.3|
Bile Duct, Hyperplasia | 4 | 2 4.0|
Hepatocyte, Degeneration, Cystic | 3 | 5 2.8|
Hepatocyte, Hyperplasia | 3 3 | 2 3.0|
Hepatocyte, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 12 |
Fat, Hemorrhage | 4| 1 4.0|
Fat, Inflammation, Granulomatous | | 1 4.0|
Fat, Necrosis | 4 2 3 3 3 3 4 | 10 3.2|
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
Cyst | | 1 3.0|
Pharyngeal, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + M| 48 |
Atrophy | 2 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 3 2 | 9 2.1|
Inflammation, Suppurative | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
Ulcer | 2 4 | 5 3.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 6| 3| 7| 7| 6| 6| 6| 4| 5| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 9| 1| 3| 7| 0| 3| 3| 6| 7| 7| 8| 3| 3| 8| 4| 1| 0| 7| 5| |
| 3| 5| 3| 8| 3| 3| 4| 6| 3| 9| 1| 3| 3| 3| 9| 4| 4| 3| 3| 7| 4| 4| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 | 1 2.0|
Atrium, Thrombosis | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Vacuolization Cytoplasmic | 3 4 2 3 2 | 6 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 4 2 | 16 2.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 3 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + M +| 48 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 2 3.0|
Hemorrhage | 4 1 | 4 3.3|
Pars Distalis, Hyperplasia | 3 2 | 9 2.9|
Pars Distalis, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 3 2 | 5 3.2|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cyst | 4 3 3 4| 10 3.1|
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 3 | 3 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 6| 3| 7| 7| 6| 6| 6| 4| 5| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 9| 1| 3| 7| 0| 3| 3| 6| 7| 7| 8| 3| 3| 8| 4| 1| 0| 7| 5| |
| 3| 5| 3| 8| 3| 3| 4| 6| 3| 9| 1| 3| 3| 3| 9| 4| 4| 3| 3| 7| 4| 4| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 4.0|
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 2 3 4 3 | 6 3.3|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 10 |
Iliac, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + A + + + + + M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + A M + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Hyperplasia, Histiocytic | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Accessory Spleen | | 1 |
Angiectasis | | 1 4.0|
Fibrosis | 4 2 4 3 3 2 3 2 3 4 | 18 2.9|
Hemorrhage | 4| 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 4 4 3 3 4 3 | 13 3.5|
Hyperplasia | 3 3 2 4 | 5 3.0|
Ulcer | | 1 4.0|
Epidermis, Cyst | | 1 3.0|
Sebaceous Gland, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 6| 3| 7| 7| 6| 6| 6| 4| 5| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 9| 1| 3| 7| 0| 3| 3| 6| 7| 7| 8| 3| 3| 8| 4| 1| 0| 7| 5| |
| 3| 5| 3| 8| 3| 3| 4| 6| 3| 9| 1| 3| 3| 3| 9| 4| 4| 3| 3| 7| 4| 4| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Cranium, Fibrosis | 3 | 1 3.0|
Cranium, Inflammation, Granulomatous | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 1 3 2 2 | 9 2.6|
Ventricle, Hydrocephalus | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Foreign Body | X X | 4 |
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
Epithelium, Metaplasia, Squamous | 2 3 | 3 2.0|
Glands, Inflammation, Suppurative | 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 2 | 3 2.3|
Alveolar Epithelium, Fibrosis | 1 1 2 | 5 1.8|
Alveolar Epithelium, Hyperplasia | 4 2 1 4 2 | 9 2.6|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 3 1 2 2 | 10 2.6|
Bronchiole, Bronchus, Interstitium, | | |
Fibrosis | 3 | 1 3.0|
Interstitium, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 3 2.0|
Foreign Body | X X X | 5 |
Inflammation, Suppurative | 2 2 4 | 3 2.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 6| 3| 7| 7| 6| 6| 6| 4| 5| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 9| 1| 3| 7| 0| 3| 3| 6| 7| 7| 8| 3| 3| 8| 4| 1| 0| 7| 5| |
| 3| 5| 3| 8| 3| 3| 4| 6| 3| 9| 1| 3| 3| 3| 9| 4| 4| 3| 3| 7| 4| 4| 3| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 3 2 1 2 3 2 4 3 3 2 3 4 1 2 2 3 3 3 4 1 4 1 3 1| 48 2.6|
Cortex, Necrosis | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + I + +| 48 |
Calculus Micro Observation Only | | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 5| 5| 7| 5| 6| 4| 5| 7| 5| 5| 5| 7| 6| 5| 6| 6| 5| 6| 4| 4|
DAY ON TEST | 6| 6| 3| 0| 3| 8| 9| 0| 0| 9| 8| 3| 3| 7| 4| 8| 2| 5| 2| 3| 2| 5| 1| 4| 7|
| 8| 8| 3| 1| 3| 0| 0| 6| 2| 2| 6| 8| 3| 8| 1| 6| 0| 0| 3| 6| 5| 2| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Parasite Metazoan | X X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Diverticulum | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 |
Basophilic Focus | X |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Thrombosis | 4 |
Vacuolization Cytoplasmic | 4 3 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Degeneration, Cystic | 3 |
Hepatocyte, Hyperplasia | 4 |
Hepatocyte, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 2 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Hyperplasia | 4 |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 1 1 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Hyperplasia | 1 3 1 1 1 2 2 2 1 |
Inflammation, Suppurative | 3 3 |
Ulcer | 2 4 3 3 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 5| 5| 7| 5| 6| 4| 5| 7| 5| 5| 5| 7| 6| 5| 6| 6| 5| 6| 4| 4|
DAY ON TEST | 6| 6| 3| 0| 3| 8| 9| 0| 0| 9| 8| 3| 3| 7| 4| 8| 2| 5| 2| 3| 2| 5| 1| 4| 7|
| 8| 8| 3| 1| 3| 0| 0| 6| 2| 2| 6| 8| 3| 8| 1| 6| 0| 0| 3| 6| 5| 2| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 3 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Penis | |
Hemorrhage | |
Thrombosis, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 4 4 |
Hyperplasia | 4 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Germinal Epithelium, Atrophy | 4 3 4 4 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 5| 5| 7| 5| 6| 4| 5| 7| 5| 5| 5| 7| 6| 5| 6| 6| 5| 6| 4| 4|
DAY ON TEST | 6| 6| 3| 0| 3| 8| 9| 0| 0| 9| 8| 3| 3| 7| 4| 8| 2| 5| 2| 3| 2| 5| 1| 4| 7|
| 8| 8| 3| 1| 3| 0| 0| 6| 2| 2| 6| 8| 3| 8| 1| 6| 0| 0| 3| 6| 5| 2| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + M + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 3 2 3 |
Hemorrhage | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 2 |
Epidermis, Cyst | |
Sebaceous Gland, Cyst | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Epidermis, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Ventricle, Hydrocephalus | 2 2 2 3 3 3|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 4| 4| 7| 6| 7| 5| 5| 7| 5| 6| 4| 5| 7| 5| 5| 5| 7| 6| 5| 6| 6| 5| 6| 4| 4|
DAY ON TEST | 6| 6| 3| 0| 3| 8| 9| 0| 0| 9| 8| 3| 3| 7| 4| 8| 2| 5| 2| 3| 2| 5| 1| 4| 7|
| 8| 8| 3| 1| 3| 0| 0| 6| 2| 2| 6| 8| 3| 8| 1| 6| 0| 0| 3| 6| 5| 2| 6| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | X X |
Epithelium, Hyperplasia | |
Epithelium, Metaplasia, Squamous | 2 |
Glands, Inflammation, Suppurative | 1 3 2 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 2 2 |
Inflammation, Granulomatous | 4 |
Alveolar Epithelium, Foreign Body | X |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolar Epithelium, Infiltration | |
Cellular, Histiocyte | 2 1 2 4 2 |
Alveolar Epithelium, Pigmentation | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cyst | 2 1 1 1 |
Foreign Body | X X |
Inflammation, Suppurative | 1 1 2 2 |
Nasopharyngeal Duct, Hyperplasia | 3 |
Olfactory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Hyperplasia | 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 4 2 1 2 2 4 1 2 4 2 1 2 2 1 1 2 2 3 3 2 2|
Artery, Inflammation | 4 |
Artery, Necrosis, Fibrinoid | 4 |
Cortex, Cyst | |
Renal Tubule, Hyperplasia, Atypical | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 4| 6| 6| 7| 6| 7| 5| 7| 7| 6| 4| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 2| 6| 1| 3| 1| 7| 8| 0| 6| 3| 7| 3| 1| 0| 8| 3| 3| 2| 6| |
| 3| 3| 1| 9| 3| 3| 0| 8| 7| 3| 9| 9| 6| 0| 4| 3| 6| 3| 5| 7| 9| 6| 3| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Inflammation, Suppurative | 3 | 1 3.0|
Parasite Metazoan | X | 3 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Diverticulum | X | 1 |
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 4 3.0|
Basophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Granulomatous | 3 3 | 2 3.0|
Mixed Cell Focus | | 1 |
Thrombosis | | 1 4.0|
Vacuolization Cytoplasmic | 4 4 4 3 | 6 3.7|
Bile Duct, Hyperplasia | 3 4 | 3 3.0|
Hepatocyte, Degeneration, Cystic | 3 2 2 1 | 5 2.2|
Hepatocyte, Hyperplasia | 4 | 2 4.0|
Hepatocyte, Necrosis | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fat, Necrosis | 3 4 4 | 7 3.1|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Gingival, Hyperplasia | | 1 4.0|
Pharyngeal, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 2 2 | 11 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 3 | 3 3.0|
Hyperplasia | 3 2 2 1 2 2| 15 1.7|
Inflammation, Suppurative | | 2 3.0|
Ulcer | 4 4 4| 9 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 4| 6| 6| 7| 6| 7| 5| 7| 7| 6| 4| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 2| 6| 1| 3| 1| 7| 8| 0| 6| 3| 7| 3| 1| 0| 8| 3| 3| 2| 6| |
| 3| 3| 1| 9| 3| 3| 0| 8| 7| 3| 9| 9| 6| 0| 4| 3| 6| 3| 5| 7| 9| 6| 3| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 3| 1 3.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 | 3 2.3|
Atrium, Thrombosis | 4 4 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 3 3 2 4 | 12 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 3.5|
Hemorrhage | 4 4 | 3 4.0|
Pars Distalis, Hyperplasia | 1 3 | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 2 2 | 8 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
Hemorrhage | 4 | 1 4.0|
Thrombosis, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 3 3 4 3 3 | 11 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 4| 6| 6| 7| 6| 7| 5| 7| 7| 6| 4| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 2| 6| 1| 3| 1| 7| 8| 0| 6| 3| 7| 3| 1| 0| 8| 3| 3| 2| 6| |
| 3| 3| 1| 9| 3| 3| 0| 8| 7| 3| 9| 9| 6| 0| 4| 3| 6| 3| 5| 7| 9| 6| 3| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 4 | 2 4.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 3 3 3 3 4 3 | 8 3.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 4 2.5|
Epithelium, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | 3 | 1 3.0|
Germinal Epithelium, Atrophy | 4 2 3 | 8 3.4|
Interstitial Cell, Hyperplasia | 1 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + M + + + + + + + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 3 4 3 4 3 | 9 3.1|
Hemorrhage | | 1 4.0|
Necrosis | 4 4| 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Parathyroid Gland | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 2 | 2 2.5|
Ulcer | 3 1 | 3 2.0|
Epidermis, Cyst | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 4| 6| 6| 7| 6| 7| 5| 7| 7| 6| 4| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 2| 6| 1| 3| 1| 7| 8| 0| 6| 3| 7| 3| 1| 0| 8| 3| 3| 2| 6| |
| 3| 3| 1| 9| 3| 3| 0| 8| 7| 3| 9| 9| 6| 0| 4| 3| 6| 3| 5| 7| 9| 6| 3| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Sebaceous Gland, Cyst | 3 | 1 3.0|
Subcutaneous Tissue, Edema | 4 | 1 4.0|
Subcutaneous Tissue, Epidermis, Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 4 4 4| 6 3.7|
Ventricle, Hydrocephalus | 3 2 | 8 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X| 3 |
Epithelium, Hyperplasia | 2| 1 2.0|
Epithelium, Metaplasia, Squamous | | 1 2.0|
Glands, Inflammation, Suppurative | 2 | 6 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 2 | 8 1.8|
Inflammation, Granulomatous | | 1 4.0|
Alveolar Epithelium, Foreign Body | | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 | 4 1.5|
Alveolar Epithelium, Infiltration | | |
Cellular, Histiocyte | 1 2 3 | 8 2.1|
Alveolar Epithelium, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 1 1 | 7 1.3|
Foreign Body | X X | 4 |
Inflammation, Suppurative | 4 2| 6 2.0|
Nasopharyngeal Duct, Hyperplasia | | 1 3.0|
Olfactory Epithelium, Degeneration | 1 4 | 3 2.0|
Respiratory Epithelium, Hyperplasia | 3 | 3 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 1 1 2 1| 10 1.5|
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 5| 5| 6| 7| 4| 6| 6| 7| 6| 7| 5| 7| 7| 6| 4| 6| 7| 7| 6| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 2| 6| 1| 3| 1| 7| 8| 0| 6| 3| 7| 3| 1| 0| 8| 3| 3| 2| 6| |
| 3| 3| 1| 9| 3| 3| 0| 8| 7| 3| 9| 9| 6| 0| 4| 3| 6| 3| 5| 7| 9| 6| 3| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 5 |
Cataract | 4 | 2 3.5|
Lens, Cataract | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 3 2 1 4 4 3 2 3 1 2 3 4 4 4 2 3 2 2 2 2 2 3 2| 48 2.4|
Artery, Inflammation | | 1 4.0|
Artery, Necrosis, Fibrinoid | | 1 4.0|
Cortex, Cyst | 4 | 1 4.0|
Renal Tubule, Hyperplasia, Atypical | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Hemorrhage | 4| 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 7| 6| 5| 6| 5| 4| 7| 5| 6| 5| 7| 7| 4| 6| 5| 4| 6| 4| 6| 6| 5|
DAY ON TEST | 3| 6| 3| 6| 3| 0| 8| 3| 4| 9| 3| 5| 3| 8| 3| 2| 4| 3| 8| 9| 5| 6| 6| 5| 7|
| 6| 4| 8| 3| 3| 7| 2| 6| 5| 4| 3| 2| 6| 1| 3| 3| 3| 7| 0| 6| 0| 5| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Reticulum Cell | |
Vacuolization Cytoplasmic | 3 2 2 2 3|
Bile Duct, Hyperplasia | 3 3 |
Hepatocyte, Degeneration, Cystic | 4 4 |
Hepatocyte, Hyperplasia | 4 |
Hepatocyte, Necrosis | 2 3 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Inflammation, Granulomatous | 2 |
Fat, Necrosis | 4 2 |
__________________________________________________________________________|
Oral Mucosa | + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 3 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 2 1 3|
Inflammation, Suppurative | 2 |
Ulcer | 2 2 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 4 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 7| 6| 5| 6| 5| 4| 7| 5| 6| 5| 7| 7| 4| 6| 5| 4| 6| 4| 6| 6| 5|
DAY ON TEST | 3| 6| 3| 6| 3| 0| 8| 3| 4| 9| 3| 5| 3| 8| 3| 2| 4| 3| 8| 9| 5| 6| 6| 5| 7|
| 6| 4| 8| 3| 3| 7| 2| 6| 5| 4| 3| 2| 6| 1| 3| 3| 3| 7| 0| 6| 0| 5| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
Atrium, Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 4 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 2 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 |
Inflammation, Suppurative | 4 2 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Artery, Inflammation | 2 |
Germinal Epithelium, Atrophy | 4 4 3 3|
Interstitial Cell, Hyperplasia | 3 3 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + M + + +|
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 7| 6| 5| 6| 5| 4| 7| 5| 6| 5| 7| 7| 4| 6| 5| 4| 6| 4| 6| 6| 5|
DAY ON TEST | 3| 6| 3| 6| 3| 0| 8| 3| 4| 9| 3| 5| 3| 8| 3| 2| 4| 3| 8| 9| 5| 6| 6| 5| 7|
| 6| 4| 8| 3| 3| 7| 2| 6| 5| 4| 3| 2| 6| 1| 3| 3| 3| 7| 0| 6| 0| 5| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 4 3 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 2 |
Inflammation, Suppurative | 2 |
Ulcer | 3 3 4 3|
Epidermis, Cyst | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
Hemorrhage | 2 4 2|
Ventricle, Hydrocephalus | 3 3 2 3 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X |
Inflammation, Suppurative | 1 |
Epiglottis, Metaplasia, Squamous | |
Epithelium, Hyperplasia | 1 |
Epithelium, Metaplasia, Squamous | 2 2 2 3 |
Glands, Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 3 2 |
Alveolar Epithelium, Hyperplasia | 4 2 |
Alveolar Epithelium, Infiltration | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
_____________________________________________________________________________________________________________________
| 6| 6| 6| 4| 7| 6| 5| 6| 5| 4| 7| 5| 6| 5| 7| 7| 4| 6| 5| 4| 6| 4| 6| 6| 5|
DAY ON TEST | 3| 6| 3| 6| 3| 0| 8| 3| 4| 9| 3| 5| 3| 8| 3| 2| 4| 3| 8| 9| 5| 6| 6| 5| 7|
| 6| 4| 8| 3| 3| 7| 2| 6| 5| 4| 3| 2| 6| 1| 3| 3| 3| 7| 0| 6| 0| 5| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Cellular, Histiocyte | 3 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Foreign Body | X X X X X |
Inflammation, Suppurative | 2 2 2 1 1 2 3 3 |
Nasopharyngeal Duct, Inflammation, | |
Suppurative | |
Nasopharyngeal Duct, Metaplasia, | |
Squamous | |
Olfactory Epithelium, Degeneration | 2 1 1 2 1 2 1 1 1 2 1 1 1 1 1 2 1 2 2 1 1|
Respiratory Epithelium, Hyperplasia | 1 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 1 1 1 1 1 2 2 2 1 2 1 1 3 2 1 2 1 3 2|
Vomeronasal Organ, Dilatation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 4 |
Cornea, Lens, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 3 3 3 3 3 2 2 3 2 3 1 2 3 3 2 3 3 1 2 1 4 3 4|
Cortex, Necrosis | 4 3 |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 4| 4| 7| 5| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 4| 6| 7| 7| 6| 6| 6| |
DAY ON TEST | 3| 7| 3| 5| 4| 9| 3| 2| 1| 3| 3| 7| 3| 8| 3| 3| 5| 9| 6| 2| 2| 3| 4| 8| 7| |
| 3| 9| 3| 8| 1| 1| 3| 0| 5| 3| 3| 8| 8| 4| 3| 2| 2| 0| 8| 4| 0| 3| 5| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Edema | | 1 3.0|
Parasite Metazoan | X X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Hyperplasia, Reticulum Cell | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 3 4 | 8 2.6|
Bile Duct, Hyperplasia | 3 | 3 3.0|
Hepatocyte, Degeneration, Cystic | 3 2 | 4 3.3|
Hepatocyte, Hyperplasia | 4 | 2 4.0|
Hepatocyte, Necrosis | 3 | 3 2.7|
Serosa, Fibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Fat, Inflammation, Granulomatous | | 1 2.0|
Fat, Necrosis | 3 4 4 2 4 | 7 3.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 7 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 2 | 2 2.5|
Hyperplasia | 4 2 2 3 | 7 2.4|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 4 | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 60968-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTYRALDEHYDE Date: 08/06/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:03:02
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 4| 4| 7| 5| 6| 7| 7| 6| 6| 6| 7| 6| 6| 5| 4| 6| 7| 7| 6| 6| 6| |
DAY ON TEST | 3| 7| 3| 5| 4| 9| 3| 2| 1| 3| 3| 7| 3| 8| 3| 3| 5| 9| 6| 2| 2| 3| 4| 8| 7| |
| 3| 9| 3| 8| 1| 1| 3| 0| 5| 3| 3| 8| 8| 4| 3| 2| 2| 0| 8| 4| 0| 3| 5| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 38 |
Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2| 8 2.3|
Mineralization | 3 | 1 3.0|
Atrium, Thrombosis | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 4 4 3 2 4 | 14 3.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 4 3 | 7 3.0|
Pars Distalis, Hyperplasia | 3 | 6 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |