TDMS Study 61427-07 Pathology Tables
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
FINAL#2/RATS
Facility: Battelle Northwest
Chemical CAS #: 1314-62-1
Lock Date: 08/18/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 20 17 15
Natural Death 3 6 4 5
Survivors
Terminal Sacrifice 33 24 29 30
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Periesophageal Tissue, Inflammation, Chronic
Active 1 [2.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [3.0] 1 [1.0] 2 [2.5]
Basophilic Focus 2
Basophilic Focus, Multiple 2 2
Bile Stasis 1 [3.0]
Clear Cell Focus 1 4 7 4
Clear Cell Focus, Multiple 2 1
Hepatodiaphragmatic Nodule 9 9 10 13
Inflammation, Granulomatous 1 [2.0]
Vacuolization Cytoplasmic 6 [3.3] 8 [2.9] 5 [2.8] 7 [2.3]
Bile Duct, Dilatation 1 [4.0]
Bile Duct, Hyperplasia 1 [2.0] 2 [1.5] 1 [3.0] 1 [2.0]
Hepatocyte, Degeneration, Cystic 1 [2.0]
Hepatocyte, Necrosis 1 [3.0] 1 [3.0]
Hepatocyte, Regeneration 1 [3.0]
Portal, Inflammation, Chronic Active 1 [2.0]
Portal, Pigmentation 2 [2.5] 1 [3.0]
Serosa, Fibrosis 1 [1.0] 1 [2.0]
Mesentery (9) (20) (22) (15)
Hemorrhage 1 [3.0]
Artery, Inflammation 1 [4.0]
Fat, Necrosis 9 [2.7] 20 [2.6] 17 [2.5] 15 [2.9]
Pancreas (50) (50) (49) (50)
Acinus, Atrophy 2 [2.0] 1 [3.0]
Stomach, Forestomach (50) (50) (50) (50)
Erosion 1 [3.0]
Hyperkeratosis 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Suppurative 1 [2.0] 2 [3.0]
Ulcer 5 [3.6] 5 [3.8] 1 [3.0] 1 [3.0]
Epithelium, Hyperplasia 2 [2.0] 2 [2.5]
Stomach, Glandular (50) (50) (50) (50)
Cyst 1 [3.0]
Erosion 1 [4.0] 1 [2.0]
Inflammation, Suppurative 1 [1.0]
Epithelium, Hyperplasia 1 [1.0]
Tongue (2) (4) (2)
Epithelium, Hyperkeratosis 3 [1.3]
Epithelium, Hyperplasia 2 [2.5]
Tooth (3) (2) (2) (1)
Peridontal Tissue, Inflammation, Suppurative 3 [2.7] 1 [2.0] 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Inflammation 1 [4.0]
Mineralization 1 [4.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 3 [2.0] 1 [1.0] 1 [2.0] 2 [1.5]
Ventricle, Thrombosis 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Hyperplasia 1 [1.0] 1 [3.0] 1 [3.0]
Necrosis 2 [2.5] 1 [1.0] 1 [4.0]
Vacuolization Cytoplasmic 9 [2.0] 7 [2.0] 4 [1.8] 3 [2.3]
Adrenal Medulla (49) (50) (50) (50)
Angiectasis 1 [2.0]
Hyperplasia 2 [3.5] 2 [2.0] 1 [3.0] 5 [2.6]
Necrosis 1 [4.0]
Islets, Pancreatic (49) (50) (49) (50)
Hyperplasia 1 [2.0] 1 [2.0]
Parathyroid Gland (45) (47) (49) (50)
Hyperplasia 1 [2.0]
Pituitary Gland (49) (50) (49) (50)
Angiectasis 1 [4.0]
Cyst 4 [3.5] 3 [4.0] 1 [2.0] 3 [3.3]
Hemorrhage 1 [4.0] 3 [3.7]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pigmentation 1 [3.0]
Pars Distalis, Cyst 1 [2.0]
Pars Distalis, Hyperplasia 12 [3.1] 6 [2.5] 16 [2.8] 4 [3.0]
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 6 [1.7] 5 [1.6] 2 [1.5] 5 [2.0]
Follicular Cell, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (49) (50)
Cyst 1 [4.0] 3 [3.7] 1 [2.0] 1 [3.0]
Hyperplasia 2 [3.5] 3 [3.3] 2 [2.5]
Inflammation, Chronic 1 [3.0]
Ovary (50) (50) (50) (50)
Atrophy 1 [4.0] 1 [3.0]
Cyst 4 [2.8] 10 [3.0] 7 [2.3] 12 [2.8]
Inflammation, Chronic 1 [3.0] 1 [3.0]
Inflammation, Granulomatous 1 [2.0]
Follicle, Cyst 2 [2.5] 1 [3.0] 1 [3.0]
Granulosa Cell, Hyperplasia 1 [3.0]
Uterus (50) (50) (50) (50)
Hydrometra 1 [3.0]
Necrosis 1 [4.0]
Endometrium, Hyperplasia 1 [2.0] 4 [2.3] 4 [2.5]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Megakaryocyte 1 [4.0]
Myelofibrosis 1 [2.0] 1 [2.0]
Lymph Node (3) (3) (3) (2)
Iliac, Ectasia 1 [4.0]
Pancreatic, Pigmentation 1 [3.0]
Lymph Node, Bronchial (42) (45) (44) (44)
Pigmentation 16 [1.2] 6 [1.3] 8 [1.3] 5 [1.2]
Lymph Node, Mesenteric (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 1 [4.0]
Hemorrhage 1 [2.0]
Lymph Node, Mediastinal (48) (50) (50) (48)
Angiectasis 1 [3.0]
Hyperplasia, Lymphoid 1 [3.0]
Pigmentation 26 [1.3] 14 [1.1] 20 [1.1] 24 [1.2]
Spleen (50) (50) (50) (50)
Accessory Spleen 3 1
Fibrosis 2 [2.5] 3 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 1 [4.0] 2 [3.5]
Hemorrhage 3 [3.3]
Necrosis 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 5 [3.0] 2 [1.0] 4 [1.5] 6 [2.8]
Epithelium, Hyperplasia 3 [2.0]
Skin (50) (50) (50) (50)
Cyst 1 [4.0] 1 [3.0]
Hyperkeratosis 1 [2.0]
Inflammation, Acute 1 [4.0]
Inflammation, Chronic 1 [3.0]
Inflammation, Suppurative 1 [2.0]
Ulcer 1 [3.0] 1 [3.0] 1 [3.0]
Hair Follicle, Atrophy 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 [3.0] 1 [3.0]
Skeletal Muscle (2) (2) (2)
Degeneration 1 [2.0]
Fibrosis 1 [3.0]
Inflammation, Chronic Active 1 [4.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 [3.0] 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Hemorrhage 3 [3.3] 6 [2.8] 3 [1.3]
Thrombosis 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (50)
Foreign Body 3 6 1
Hemorrhage 1 [1.0] 1 [2.0]
Inflammation, Chronic 8 [1.8] 26 [1.5] 27 [1.3] 37 [1.4]
Inflammation, Suppurative 5 [1.4] 2 [1.5] 3 [1.3] 2 [2.5]
Ulcer 1 [2.0]
Respiratory Epithelium, Epiglottis,
Degeneration 2 [1.0] 33 [1.2] 26 [1.2] 40 [1.5]
Respiratory Epithelium, Epiglottis,
Hyperplasia 25 [1.4] 26 [1.3] 33 [1.5]
Respiratory Epithelium, Epiglottis,
Metaplasia, Squamous 2 [2.0] 7 [1.9] 7 [1.7] 16 [1.4]
Lung (49) (49) (50) (50)
Edema 1 [4.0]
Hemorrhage 1 [2.0] 1 [2.0]
Inflammation 1 [2.0]
Inflammation, Chronic Active 10 [1.5] 10 [1.1] 14 [1.2] 40 [1.7]
Inflammation, Suppurative 2 [1.5]
Alveolar Epithelium, Hyperplasia 4 [1.0] 8 [1.8] 21 [1.2] 50 [3.1]
Alveolar Epithelium, Metaplasia, Squamous 6 [3.0]
Alveolar Epithelium, Regeneration 1 [3.0]
Alveolus, Infiltration Cellular, Histiocyte 26 [1.4] 35 [1.3] 44 [2.0] 50 [3.1]
Alveolus, Pigmentation 1 [1.0] 1 [1.0] 8 [1.3] 7 [1.9]
Artery, Mineralization 1 [4.0]
Bronchiole, Foreign Body 1
Bronchiole, Hyperplasia 6 [1.5] 5 [1.6] 14 [1.3] 48 [3.0]
Bronchiole, Inflammation, Suppurative 1 [3.0]
Bronchiole, Metaplasia, Squamous 1 [2.0]
Interstitium, Fibrosis 19 [1.4] 7 [1.3] 12 [1.6] 32 [1.4]
Nose (50) (50) (50) (50)
Foreign Body 3 4 1 2
Inflammation, Chronic 1 [1.0]
Inflammation, Suppurative 3 [2.3] 6 [2.2] 5 [1.8] 10 [1.8]
Goblet Cell, Respiratory Epithelium,
Hyperplasia 13 [2.0] 18 [2.0] 16 [1.9] 30 [2.0]
Nasolacrimal Duct, Inflammation, Suppurative 2 [2.5] 4 [1.3] 2 [2.5] 7 [2.0]
Olfactory Epithelium, Degeneration, Hyaline 16 [1.1] 20 [1.3] 6 [1.7] 4 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Hyperplasia 1 [2.0] 2 [2.5] 1 [2.0] 2 [1.5]
Respiratory Epithelium, Metaplasia, Squamous 2 [2.5] 1 [2.0]
Respiratory Epithelium, Ulcer 1 [3.0]
Pleura (3)
Inflammation, Chronic 3 [1.3]
Trachea (50) (50) (49) (50)
Foreign Body 1
Inflammation, Chronic 1 [1.0]
Inflammation, Suppurative 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (3)
Lens, Cataract 3 [3.0] 3 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Accumulation, Hyaline Droplet 1 [4.0]
Nephropathy, Chronic 24 [1.4] 21 [1.4] 20 [1.3] 32 [1.7]
Thrombosis 1 [2.0]
Cortex, Renal Tubule, Necrosis 1 [1.0] 1 [4.0]
Papilla, Mineralization 1 [3.0] 2 [2.0]
Pelvis, Dilatation 1 [4.0]
Renal Tubule, Mineralization 1 [2.0]
Renal Tubule, Vacuolization Cytoplasmic 1 [4.0]
Urinary Bladder (50) (50) (50) (50)
Transitional Epithelium, Hyperplasia 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 25 17 18 13
Natural Death 5 4 6 10
Survivors
Terminal Sacrifice 20 29 26 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (47) (49) (47) (48)
Thrombosis 1 [3.0]
Intestine Small, Duodenum (47) (49) (46) (48)
Inflammation, Suppurative 1 [2.0]
Liver (50) (50) (49) (50)
Basophilic Focus 1 1
Bile Stasis 1 [3.0]
Clear Cell Focus 3 2 1 7
Hepatodiaphragmatic Nodule 5 8 7 14
Inflammation, Granulomatous 2 [2.0]
Mixed Cell Focus 1
Thrombosis 1 [3.0]
Vacuolization Cytoplasmic 5 [3.2] 4 [2.0] 8 [2.6] 5 [2.8]
Bile Duct, Dilatation 1 [4.0]
Bile Duct, Hyperplasia 11 [1.8] 8 [1.6] 8 [1.5] 14 [2.0]
Hepatocyte, Degeneration, Cystic 3 [2.0] 2 [4.0]
Hepatocyte, Necrosis 1 [4.0] 1 [3.0]
Hepatocyte, Regeneration 1 [4.0] 1 [4.0] 2 [3.5]
Portal, Inflammation, Chronic Active 4 [1.8] 1 [1.0] 4 [1.8]
Portal, Pigmentation 3 [3.3]
Serosa, Inflammation, Suppurative 1 [4.0]
Mesentery (8) (18) (12) (9)
Hemorrhage 1 [3.0] 1 [3.0] 1 [2.0]
Artery, Inflammation 1 [4.0]
Fat, Hemorrhage 1 [2.0]
Fat, Necrosis 7 [2.4] 16 [2.9] 9 [2.2] 8 [3.0]
Oral Mucosa (3) (4)
Inflammation, Suppurative 1 [2.0]
Pharyngeal, Hyperplasia, Squamous 1 [4.0]
Pharyngeal, Ulcer 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (49) (50)
Infiltration Cellular, Lipocyte 1 [3.0]
Acinus, Atrophy 3 [2.0] 4 [1.8] 1 [3.0]
Acinus, Hyperplasia 3 [2.3]
Artery, Inflammation 2 [4.0]
Stomach, Forestomach (50) (50) (49) (50)
Cyst 1 [4.0]
Diverticulum 1 2
Hyperkeratosis 1 [3.0]
Inflammation, Suppurative 1 [4.0] 1 [3.0] 1 [4.0]
Necrosis 1 [4.0]
Ulcer 3 [3.7] 3 [3.3] 4 [3.5] 3 [3.0]
Arteriole, Necrosis 1 [3.0]
Epithelium, Hyperplasia 1 [3.0] 3 [2.3] 2 [3.0]
Stomach, Glandular (50) (50) (49) (50)
Erosion 1 [4.0] 1 [2.0]
Inflammation, Suppurative 1 [4.0]
Necrosis 2 [2.5] 1 [3.0] 2 [2.0] 1 [1.0]
Tongue (1) (2)
Epithelium, Hyperplasia 1 [2.0] 1 [3.0]
Tooth (7) (1) (2) (5)
Peridontal Tissue, Inflammation, Suppurative 7 [2.1] 1 [3.0] 2 [2.5] 4 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (49) (50)
Aorta, Thrombosis 1 [4.0]
Heart (50) (50) (49) (50)
Cardiomyopathy 7 [1.4] 7 [1.6] 7 [1.6] 7 [2.3]
Atrium, Thrombosis 2 [2.5] 2 [3.5]
Pericardium, Fibrosis 1 [1.0]
Valve, Hemorrhage 1 [3.0]
Ventricle, Hypertrophy 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Angiectasis 1 [4.0]
Hemorrhage 1 [3.0]
Hyperplasia 1 [1.0] 1 [2.0]
Necrosis 1 [4.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 9 [1.9] 5 [1.6] 7 [2.6] 5 [2.2]
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 16 [2.1] 8 [2.4] 12 [3.0] 10 [2.7]
Necrosis 1 [4.0]
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 1 [3.0] 1 [2.0] 1 [2.0]
Pituitary Gland (50) (50) (50) (50)
Angiectasis 1 [4.0] 1 [4.0]
Hemorrhage 3 [4.0] 1 [4.0] 1 [4.0]
Pars Distalis, Hyperplasia 2 [2.5] 5 [3.0] 5 [3.2] 4 [3.8]
Thyroid Gland (50) (50) (49) (50)
C-Cell, Hyperplasia 9 [2.2] 4 [2.0] 4 [2.8] 7 [1.4]
Follicular Cell, Hyperplasia 2 [3.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50)
Inflammation, Granulomatous 1 [3.0]
Spermatocele 1 [3.0]
Penis (2) (3)
Hyperplasia, Squamous 1 [4.0]
Necrosis 1 [4.0] 1 [4.0]
Preputial Gland (50) (50) (49) (50)
Hyperplasia 1 [3.0] 1 [3.0] 2 [3.5]
Inflammation, Chronic 3 [3.0] 1 [4.0]
Prostate (50) (50) (49) (50)
Fibrosis 1 [4.0]
Hyperplasia 1 [1.0] 2 [1.5] 3 [1.0]
Inflammation, Granulomatous 1 [3.0]
Inflammation, Suppurative 12 [2.8] 8 [1.9] 8 [2.9] 6 [2.5]
Seminal Vesicle (50) (50) (49) (50)
Hyperplasia 1 [2.0]
Inflammation, Granulomatous 1 [3.0]
Inflammation, Suppurative 1 [4.0] 2 [2.5]
Testes (50) (50) (50) (50)
Inflammation, Suppurative 1 [3.0]
Necrosis 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Artery, Inflammation 2 [2.0]
Germinal Epithelium, Atrophy 6 [3.5] 6 [3.8] 13 [3.6] 10 [3.8]
Interstitial Cell, Hyperplasia 2 [2.5] 7 [2.4] 5 [2.2] 3 [1.7]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Lymphoid 1 [3.0] 1 [3.0]
Myelofibrosis 1 [3.0]
Lymph Node (2) (3) (2) (5)
Inflammation, Granulomatous 1 [3.0]
Pancreatic, Pigmentation 1 [3.0]
Lymph Node, Bronchial (39) (44) (47) (44)
Fibrosis 1 [2.0]
Pigmentation 8 [1.4] 8 [1.3] 3 [1.3] 12 [1.6]
Lymph Node, Mandibular (44) (48) (46) (45)
Ectasia 1 [3.0]
Hyperplasia, Lymphoid 1 [3.0]
Inflammation, Acute 1 [3.0] 1 [3.0] 1 [2.0]
Lymph Node, Mediastinal (45) (47) (46) (44)
Angiectasis 1 [4.0]
Inflammation, Granulomatous 2 [3.5]
Pigmentation 17 [1.4] 15 [1.3] 17 [1.5] 17 [1.8]
Spleen (50) (50) (48) (50)
Accessory Spleen 1 1
Fibrosis 7 [2.9] 16 [2.9] 12 [2.5] 11 [2.7]
Hematopoietic Cell Proliferation 4 [3.3]
Hemorrhage 8 [3.9] 4 [3.5] 1 [4.0]
Necrosis 2 [4.0] 1 [4.0] 1 [4.0]
Pigmentation 1 [3.0] 1 [4.0]
Thymus (49) (49) (49) (50)
Hemorrhage 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (49) (50)
Galactocele 2 [3.5] 1 [3.0] 5 [2.6] 4 [2.3]
Skin (50) (50) (50) (50)
Cyst 2 [4.0] 1 [4.0] 1 [3.0] 6 [3.8]
Cyst, Multiple 1 [4.0]
Hyperkeratosis 4 [3.3] 2 [2.5] 3 [2.7] 3 [3.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia 1 [2.0]
Inflammation, Acute 1 [3.0]
Ulcer 1 [4.0]
Hair Follicle, Atrophy 1 [2.0]
Subcutaneous Tissue, Edema 1 [3.0]
Subcutaneous Tissue, Fibrosis 1 [1.0]
Subcutaneous Tissue, Inflammation,
Granulomatous 1 [2.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Vertebra, Fracture 1
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Hemorrhage 5 [3.0] 3 [3.3] 2 [2.5] 4 [3.5]
Hydrocephalus 1 [4.0]
Necrosis 1 [3.0] 1 [2.0]
Medulla, Demyelination, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (49)
Foreign Body 3 3 2 2
Hyperkeratosis 1 [2.0]
Inflammation, Chronic 3 [1.0] 20 [1.1] 17 [1.5] 28 [1.6]
Inflammation, Suppurative 11 [1.5] 3 [2.3] 4 [2.5] 13 [2.1]
Respiratory Epithelium, Ulcer 1 [3.0]
Respiratory Epithelium, Epiglottis,
Degeneration 22 [1.1] 23 [1.1] 33 [1.5]
Respiratory Epithelium, Epiglottis,
Hyperplasia 18 [1.5] 34 [1.5] 32 [1.9]
Respiratory Epithelium, Epiglottis,
Metaplasia, Squamous 9 [1.7] 16 [1.8] 19 [2.1]
Lung (50) (49) (48) (50)
Hemorrhage 5 [2.8] 1 [2.0] 2 [2.0] 1 [3.0]
Inflammation, Chronic Active 5 [1.6] 8 [1.8] 24 [1.3] 42 [2.4]
Inflammation, Suppurative 2 [3.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Metaplasia 1 [1.0]
Mineralization 2 [1.5] 1 [1.0]
Alveolar Epithelium, Hyperplasia 7 [2.3] 24 [2.0] 34 [2.0] 49 [3.3]
Alveolar Epithelium, Metaplasia, Squamous 1 [1.0] 21 [3.6]
Alveolus, Infiltration Cellular, Histiocyte 22 [1.3] 40 [2.0] 45 [2.3] 50 [3.3]
Alveolus, Pigmentation 1 [2.0] 2 [1.5] 28 [2.1]
Artery, Mineralization 1 [3.0]
Bronchiole, Hyperplasia 3 [2.3] 17 [2.2] 31 [1.8] 49 [3.3]
Bronchiole, Metaplasia, Squamous 7 [3.7]
Interstitium, Edema 1 [2.0]
Interstitium, Fibrosis 7 [1.4] 7 [2.0] 16 [1.6] 38 [2.1]
Mediastinum, Hemorrhage 1 [4.0]
Nose (49) (50) (49) (48)
Foreign Body 3 5 1 1
Inflammation, Chronic 1 [1.0] 1 [2.0]
Inflammation, Suppurative 8 [2.1] 7 [2.0] 3 [1.7] 11 [2.2]
Goblet Cell, Respiratory Epithelium,
Hyperplasia 4 [1.8] 15 [1.8] 12 [2.0] 17 [2.1]
Nasolacrimal Duct, Inflammation, Suppurative 1 [3.0] 2 [2.0]
Olfactory Epithelium, Degeneration, Hyaline 9 [1.2] 3 [1.7] 1 [2.0] 4 [1.3]
Respiratory Epithelium, Degeneration, Hyaline 1 [1.0]
Respiratory Epithelium, Hyperplasia 2 [2.0] 1 [2.0] 1 [1.0] 3 [3.0]
Respiratory Epithelium, Metaplasia, Squamous 3 [2.0] 1 [1.0] 3 [1.3]
Respiratory Epithelium, Mineralization 1 [2.0]
Pleura (2) (1)
Inflammation 1 [1.0]
Trachea (50) (50) (49) (50)
Foreign Body 1
Inflammation, Suppurative 1 [3.0]
Epithelium, Degeneration 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (2) (3)
Atrophy 1 [4.0] 1 [1.0] 1 [4.0]
Lens, Cataract 2 [1.5] 1 [2.0] 2 [3.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Accumulation, Hyaline Droplet 1 [4.0] 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 61427-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:03:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 1.0 2.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infarct 1 [4.0] 1 [4.0]
Infiltration Cellular, Lipocyte 1 [4.0]
Nephropathy, Chronic 37 [2.4] 42 [2.1] 46 [2.1] 47 [2.3]
Cortex, Cyst 2 [3.5]
Pelvis, Dilatation 1 [1.0]
Renal Tubule, Pigmentation 1 [3.0] 1 [4.0]
Urethra (1)
Inflammation, Suppurative 1 [4.0]
Urinary Bladder (49) (50) (48) (50)
Calculus Micro Observation Only 1 1
Hemorrhage 1 [4.0] 1 [1.0]
Inflammation 1 [3.0]
Transitional Epithelium, Hyperplasia 2 [2.5] 1 [3.0] 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
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