TDMS Study 61427-07 Pathology Tables
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
FINAL#2/RATS
Facility: Battelle Northwest
Chemical CAS #: 1314-62-1
Lock Date: 08/18/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3|
| 1| 1| 2| 2| 3| 2| 8| 4| 2| 2| 3| 2| 8| 3| 3| 3| 1| 8| 8| 1| 2| 2| 1| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Inflammation, | |
Chronic Active | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Bile Stasis | |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X X X X X |
Vacuolization Cytoplasmic | 3 4 |
Bile Duct, Hyperplasia | |
Hepatocyte, Regeneration | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Inflammation | |
Fat, Necrosis | 3 2 2 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3|
| 1| 1| 2| 2| 3| 2| 8| 4| 2| 2| 3| 2| 8| 3| 3| 3| 1| 8| 8| 1| 2| 2| 1| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 4 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Erosion | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 4 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | 1 4 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4|
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 4 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3|
| 1| 1| 2| 2| 3| 2| 8| 4| 2| 2| 3| 2| 8| 3| 3| 3| 1| 8| 8| 1| 2| 2| 1| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | 4 2 4 |
Follicle, Cyst | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | 4|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + M + + M + + +|
Pigmentation | 1 1 1 2 1 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + M + + + M M + + + + M + + + + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pigmentation | 2 2 1 1 2 2 1 1 2 1 1|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3|
| 1| 1| 2| 2| 3| 2| 8| 4| 2| 2| 3| 2| 8| 3| 3| 3| 1| 8| 8| 1| 2| 2| 1| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 1 2 2 1 |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 1 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3|
| 1| 1| 2| 2| 3| 2| 8| 4| 2| 2| 3| 2| 8| 3| 3| 3| 1| 8| 8| 1| 2| 2| 1| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + A + + + + + + +|
Edema | |
Hemorrhage | |
Inflammation, Chronic Active | 1 1 1 2 2 |
Inflammation, Suppurative | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 |
Alveolus, Pigmentation | 1 |
Artery, Mineralization | |
Bronchiole, Foreign Body | |
Bronchiole, Hyperplasia | 1 1 1 1 |
Bronchiole, Inflammation, Suppurative| |
Interstitium, Fibrosis | 1 2 1 2 1 1 3 1 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Pleura | + + |
Inflammation, Chronic | 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3|
| 1| 1| 2| 2| 3| 2| 8| 4| 2| 2| 3| 2| 8| 3| 3| 3| 1| 8| 8| 1| 2| 2| 1| 2| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Lens, Cataract | 3 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 1 1 1 4 1 1 1 1 1 |
Cortex, Renal Tubule, Necrosis | 1 |
Pelvis, Dilatation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 2| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 0| 3| 3| 3| 3| 1| 3| 2| 3| 3| 9| 6| 3| 2| 6| 3| 1| 3| 2| 3| 3| 3| |
| 3| 1| 1| 8| 1| 1| 3| 2| 9| 3| 0| 2| 4| 8| 6| 3| 5| 6| 1| 7| 3| 2| 3| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Periesophageal Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X | 2 |
Bile Stasis | 3 | 1 3.0|
Clear Cell Focus | | 1 |
Hepatodiaphragmatic Nodule | X X | 9 |
Vacuolization Cytoplasmic | 3 4 4 2 | 6 3.3|
Bile Duct, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Regeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Artery, Inflammation | 4 | 1 4.0|
Fat, Necrosis | 3 3 3 2 | 9 2.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 2| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 0| 3| 3| 3| 3| 1| 3| 2| 3| 3| 9| 6| 3| 2| 6| 3| 1| 3| 2| 3| 3| 3| |
| 3| 1| 1| 8| 1| 1| 3| 2| 9| 3| 0| 2| 4| 8| 6| 3| 5| 6| 1| 7| 3| 2| 3| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | 4 4 2 | 5 3.6|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Erosion | 4 | 1 4.0|
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + | 3 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1| 1 1.0|
Vacuolization Cytoplasmic | 2 1 3 2 | 9 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 3.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 2| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 0| 3| 3| 3| 3| 1| 3| 2| 3| 3| 9| 6| 3| 2| 6| 3| 1| 3| 2| 3| 3| 3| |
| 3| 1| 1| 8| 1| 1| 3| 2| 9| 3| 0| 2| 4| 8| 6| 3| 5| 6| 1| 7| 3| 2| 3| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + M + + + + M + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Cyst | 2 4 | 4 3.5|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 3 3 4 2 3 2 4| 12 3.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Hyperplasia | 3 4 | 2 3.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Cyst | 1 | 4 2.8|
Follicle, Cyst | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Megakaryocyte | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 2| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 0| 3| 3| 3| 3| 1| 3| 2| 3| 3| 9| 6| 3| 2| 6| 3| 1| 3| 2| 3| 3| 3| |
| 3| 1| 1| 8| 1| 1| 3| 2| 9| 3| 0| 2| 4| 8| 6| 3| 5| 6| 1| 7| 3| 2| 3| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + M + M + I + + + + + + M +| 42 |
Pigmentation | 1 1 1 2 1 1 2 1 1| 16 1.2|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + M + + +| 42 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Pigmentation | 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 3 |
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 2 4 4 | 5 3.0|
Epithelium, Hyperplasia | 3 2 | 3 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 2| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 0| 3| 3| 3| 3| 1| 3| 2| 3| 3| 9| 6| 3| 2| 6| 3| 1| 3| 2| 3| 3| 3| |
| 3| 1| 1| 8| 1| 1| 3| 2| 9| 3| 0| 2| 4| 8| 6| 3| 5| 6| 1| 7| 3| 2| 3| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 3.0|
Hemorrhage | 2 | 3 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 3 2.0|
Inflammation, Chronic | 1 2 2 1 4 2 | 8 1.8|
Inflammation, Suppurative | 1 | 5 1.4|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 | 2 1.0|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 4 | 1 4.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 3 2 1 | 10 1.5|
Inflammation, Suppurative | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 4 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 2 3 1 4 2 1 | 26 1.4|
Alveolus, Pigmentation | | 1 1.0|
Artery, Mineralization | 4 | 1 4.0|
Bronchiole, Foreign Body | X | 1 |
Bronchiole, Hyperplasia | 2 3 | 6 1.5|
Bronchiole, Inflammation, Suppurative| 3 | 1 3.0|
Interstitium, Fibrosis | 1 2 1 1 1 3 1 1 1 | 19 1.4|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 2| 6| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 3| 0| 3| 3| 3| 3| 1| 3| 2| 3| 3| 9| 6| 3| 2| 6| 3| 1| 3| 2| 3| 3| 3| |
| 3| 1| 1| 8| 1| 1| 3| 2| 9| 3| 0| 2| 4| 8| 6| 3| 5| 6| 1| 7| 3| 2| 3| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X X | 3 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Suppurative | 2 2 3 | 3 2.3|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 2 2 2 2 2 2 | 13 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 2 1 1 1 1 | 16 1.1|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pleura | + | 3 |
Inflammation, Chronic | 1 | 3 1.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 2 | 3 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 2 1 1 2 1 2 1 1 1 1 2| 24 1.4|
Cortex, Renal Tubule, Necrosis | | 1 1.0|
Pelvis, Dilatation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 4| 5| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 8| 9| 0| 3| 3| 3| 1| 7| 1| 7| 1| 3| 1| 0| 7| 0| 9| 5| 3| 3| 3|
| 1| 1| 2| 3| 2| 4| 1| 2| 2| 3| 2| 5| 7| 1| 7| 3| 0| 8| 1| 8| 5| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + A + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + A + + + A + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + A + + + A + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + + + A + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus, Multiple | X |
Clear Cell Focus | X|
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Granulomatous | 2 |
Vacuolization Cytoplasmic | 3 4 |
Bile Duct, Hyperplasia | 2 1|
Portal, Pigmentation | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + |
Fat, Necrosis | 3 3 2 3 3 3 3 2 4 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 4 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 4| 5| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 8| 9| 0| 3| 3| 3| 1| 7| 1| 7| 1| 3| 1| 0| 7| 0| 9| 5| 3| 3| 3|
| 1| 1| 2| 3| 2| 4| 1| 2| 2| 3| 2| 5| 7| 1| 7| 3| 0| 8| 1| 8| 5| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Tongue | + + |
|__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Necrosis | |
Vacuolization Cytoplasmic | 3 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + M + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 4 4 4|
Pigmentation | 3 |
Pars Distalis, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 4| 5| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 8| 9| 0| 3| 3| 3| 1| 7| 1| 7| 1| 3| 1| 0| 7| 0| 9| 5| 3| 3| 3|
| 1| 1| 2| 3| 2| 4| 1| 2| 2| 3| 2| 5| 7| 1| 7| 3| 0| 8| 1| 8| 5| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 3 4 3 3|
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | 2 |
Follicle, Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + M + + + + + + + + + M + + + +|
Pigmentation | 1 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + M + + + + M + M + M + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 4| 5| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 8| 9| 0| 3| 3| 3| 1| 7| 1| 7| 1| 3| 1| 0| 7| 0| 9| 5| 3| 3| 3|
| 1| 1| 2| 3| 2| 4| 1| 2| 2| 3| 2| 5| 7| 1| 7| 3| 0| 8| 1| 8| 5| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 3 |
Hemorrhage | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | 4 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration | |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X 1 X |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 4| 5| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 8| 9| 0| 3| 3| 3| 1| 7| 1| 7| 1| 3| 1| 0| 7| 0| 9| 5| 3| 3| 3|
| 1| 1| 2| 3| 2| 4| 1| 2| 2| 3| 2| 5| 7| 1| 7| 3| 0| 8| 1| 8| 5| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation, Chronic | 3 3 1 4 2 1 1 2 1 2 1 1 1 |
Inflammation, Suppurative | 1 |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 1 1 3 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 |
Respiratory Epithelium, Epiglottis, | |
Hyperplasia | 1 1 2 1 1 1 1 2 1 1 1 2 1 1 2 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 2 2 2 2 2 |
|__________________________________________________________________________|
Lung | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 1 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 2 1 2 2 1 1 2 1 1 1 1 1|
Alveolus, Pigmentation | 1 |
Bronchiole, Hyperplasia | 1 1 1 |
Interstitium, Fibrosis | 2 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 X |
Inflammation, Suppurative | 2 3 1 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 2 1 1 |
Respiratory Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 4| 5| 6| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 8| 9| 0| 3| 3| 3| 1| 7| 1| 7| 1| 3| 1| 0| 7| 0| 9| 5| 3| 3| 3|
| 1| 1| 2| 3| 2| 4| 1| 2| 2| 3| 2| 5| 7| 1| 7| 3| 0| 8| 1| 8| 5| 2| 2| 2| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 4 |
Nephropathy, Chronic | 2 1 1 2 2 1 2 1 1 2|
Thrombosis | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 19
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 6| 6| 9| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 4| 3| 3| 3| 0| |
| 2| 3| 2| 1| 7| 8| 9| 2| 3| 7| 3| 6| 3| 1| 2| 2| 3| 1| 2| 6| 0| 3| 3| 3| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus, Multiple | X | 2 |
Clear Cell Focus | X X X | 4 |
Hepatodiaphragmatic Nodule | X X X | 9 |
Inflammation, Granulomatous | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 3 4 3 3 | 8 2.9|
Bile Duct, Hyperplasia | | 2 1.5|
Portal, Pigmentation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 20 |
Fat, Necrosis | 2 1 3 3 3 3 3 2 2 | 20 2.6|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 6| 6| 9| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 4| 3| 3| 3| 0| |
| 2| 3| 2| 1| 7| 8| 9| 2| 3| 7| 3| 6| 3| 1| 2| 2| 3| 1| 2| 6| 0| 3| 3| 3| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 4 | 5 3.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 2 |
|__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 1.0|
Ventricle, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Necrosis | 3 2 | 2 2.5|
Vacuolization Cytoplasmic | 4 1 1 | 7 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 6| 6| 9| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 4| 3| 3| 3| 0| |
| 2| 3| 2| 1| 7| 8| 9| 2| 3| 7| 3| 6| 3| 1| 2| 2| 3| 1| 2| 6| 0| 3| 3| 3| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Cyst | | 3 4.0|
Pigmentation | | 1 3.0|
Pars Distalis, Hyperplasia | 3 3 3 | 6 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 2 2| 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 3 3.7|
Hyperplasia | 4 | 3 3.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 2 3 3 | 10 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
Follicle, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 6| 6| 9| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 4| 3| 3| 3| 0| |
| 2| 3| 2| 1| 7| 8| 9| 2| 3| 7| 3| 6| 3| 1| 2| 2| 3| 1| 2| 6| 0| 3| 3| 3| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | +| 3 |
Pancreatic, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + I + M + + +| 45 |
Pigmentation | 1 1 1 2 | 6 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + M + + + M + + + + M + + + + + + +| 41 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 2 2 1 1 1 | 14 1.1|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 3 | 3 3.0|
Hemorrhage | 3 3 | 3 3.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 1 4.0|
Inflammation, Acute | | 1 4.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 6| 6| 9| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 4| 3| 3| 3| 0| |
| 2| 3| 2| 1| 7| 8| 9| 2| 3| 7| 3| 6| 3| 1| 2| 2| 3| 1| 2| 6| 0| 3| 3| 3| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Degeneration | 2 | 1 2.0|
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 2 | 6 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Foreign Body | X X X | 6 1.0|
Inflammation, Chronic | 2 1 1 1 2 1 1 1 1 1 2 2 1 | 26 1.5|
Inflammation, Suppurative | 2 | 2 1.5|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.2|
Respiratory Epithelium, Epiglottis, | | |
Hyperplasia | 1 2 1 1 4 2 1 1 1 2 | 25 1.4|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 2 | 7 1.9|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 10 1.1|
Alveolar Epithelium, Hyperplasia | 1 4 4 1 | 8 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 2 1 4 2 1 1 2 1 1 1 1 2 1 1 | 35 1.3|
Alveolus, Pigmentation | | 1 1.0|
Bronchiole, Hyperplasia | 4 1 | 5 1.6|
Interstitium, Fibrosis | 1 1 2 1 | 7 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 6| 6| 9| 3| 3| 1| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 4| 3| 3| 3| 0| |
| 2| 3| 2| 1| 7| 8| 9| 2| 3| 7| 3| 6| 3| 1| 2| 2| 3| 1| 2| 6| 0| 3| 3| 3| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 4 1.0|
Inflammation, Suppurative | 3 2 2 | 6 2.2|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 2 2 1 2 3 2 2 2 2 | 18 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 | 4 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 2 1 1 3 1 1 1 2 1 1| 20 1.3|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 4.0|
Nephropathy, Chronic | 1 1 1 3 2 1 1 1 1 1 1 | 21 1.4|
Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8| 3| 0| 7| 3| 8| 3| 3|
| 2| 3| 2| 3| 1| 3| 0| 3| 1| 3| 3| 1| 2| 1| 1| 1| 3| 9| 2| 7| 2| 1| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + A + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X |
Clear Cell Focus | X X X |
Clear Cell Focus, Multiple | X 3 |
Hepatodiaphragmatic Nodule | X X X X X X |
Vacuolization Cytoplasmic | 4 1 |
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Necrosis | 3 |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Hemorrhage | |
Fat, Necrosis | 3 3 3 2 3 3 2 1 3|
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8| 3| 0| 7| 3| 8| 3| 3|
| 2| 3| 2| 3| 1| 3| 0| 3| 1| 3| 3| 1| 2| 1| 1| 1| 3| 9| 2| 7| 2| 1| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperkeratosis | 2 |
|__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Vacuolization Cytoplasmic | 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 4 3 |
Pars Distalis, Hyperplasia | 2 3 3 3 2 3 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8| 3| 0| 7| 3| 8| 3| 3|
| 2| 3| 2| 3| 1| 3| 0| 3| 1| 3| 3| 1| 2| 1| 1| 1| 3| 9| 2| 7| 2| 1| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | 2 2 3 |
Follicle, Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Endometrium, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + I + + I M + + + +|
Pigmentation | 1 2 1 1 2 1|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 1 2 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8| 3| 0| 7| 3| 8| 3| 3|
| 2| 3| 2| 3| 1| 3| 0| 3| 1| 3| 3| 1| 2| 1| 1| 1| 3| 9| 2| 7| 2| 1| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 2 2 1 1 1 1 2 1 1 2 1 |
Inflammation, Suppurative | 2 1 |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 1 1 2 1 1 1 1 1 1 1 1 1 2 2|
Respiratory Epithelium, Epiglottis, | |
Hyperplasia | 2 1 1 1 2 1 2 1 1 1 1 2 1 1 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8| 3| 0| 7| 3| 8| 3| 3|
| 2| 3| 2| 3| 1| 3| 0| 3| 1| 3| 3| 1| 2| 1| 1| 1| 3| 9| 2| 7| 2| 1| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 1 2 1 2 1 1 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 1 3 1 1 2 2 2 2 2 2 1 3 2 3 2 3|
Alveolus, Pigmentation | 2 1 1 2 1 1 1 |
Bronchiole, Hyperplasia | 2 1 1|
Interstitium, Fibrosis | 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 1 1 4 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 2 2 1 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 1 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
|__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
|__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 3 1 1 2 2 1 1 1 2 |
Cortex, Renal Tubule, Necrosis | |
Papilla, Mineralization | 3 |
Renal Tubule, Mineralization | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8| 3| 0| 7| 3| 8| 3| 3|
| 2| 3| 2| 3| 1| 3| 0| 3| 1| 3| 3| 1| 2| 1| 1| 1| 3| 9| 2| 7| 2| 1| 9| 8| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 31
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 7| 7| 7| 6| 7| 6| 7| 4| 6| 6| 7| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 2| 3| 3| 6| 1| 5| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 5| 1| 3| 9| 3| |
| 3| 0| 2| 2| 5| 3| 3| 1| 0| 2| 3| 9| 3| 1| 3| 8| 1| 8| 2| 1| 2| 7| 3| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus, Multiple | X | 2 |
Clear Cell Focus | X X X X| 7 |
Clear Cell Focus, Multiple | | 2 3.0|
Hepatodiaphragmatic Nodule | X X X X | 10 |
Vacuolization Cytoplasmic | 4 3 2 | 5 2.8|
Bile Duct, Hyperplasia | | 1 3.0|
Hepatocyte, Necrosis | | 1 3.0|
Serosa, Fibrosis | 1| 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + | 22 |
Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 2 2 2 2 3 1 4 3 | 17 2.5|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 7| 7| 7| 6| 7| 6| 7| 4| 6| 6| 7| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 2| 3| 3| 6| 1| 5| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 5| 1| 3| 9| 3| |
| 3| 0| 2| 2| 5| 3| 3| 1| 0| 2| 3| 9| 3| 1| 3| 8| 1| 8| 2| 1| 2| 7| 3| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
Ulcer | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + + + | 4 |
Epithelium, Hyperkeratosis | 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 2 | 4 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 7| 7| 7| 6| 7| 6| 7| 4| 6| 6| 7| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 2| 3| 3| 6| 1| 5| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 5| 1| 3| 9| 3| |
| 3| 0| 2| 2| 5| 3| 3| 1| 0| 2| 3| 9| 3| 1| 3| 8| 1| 8| 2| 1| 2| 7| 3| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Hemorrhage | 4 | 3 3.7|
Pars Distalis, Hyperplasia | 4 3 4 2 4 2 2 3 2 | 16 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 | 2 1.5|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cyst | 3 2 1 3 | 7 2.3|
Follicle, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 1 4.0|
Endometrium, Hyperplasia | 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 7| 7| 7| 6| 7| 6| 7| 4| 6| 6| 7| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 2| 3| 3| 6| 1| 5| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 5| 1| 3| 9| 3| |
| 3| 0| 2| 2| 5| 3| 3| 1| 0| 2| 3| 9| 3| 1| 3| 8| 1| 8| 2| 1| 2| 7| 3| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + I + + M + + +| 44 |
Pigmentation | 1 1 | 8 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + M + + + + + + + + + + + + + + + + + M +| 45 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1| 20 1.1|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 3 | 4 1.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 7| 7| 7| 6| 7| 6| 7| 4| 6| 6| 7| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 2| 3| 3| 6| 1| 5| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 5| 1| 3| 9| 3| |
| 3| 0| 2| 2| 5| 3| 3| 1| 0| 2| 3| 9| 3| 1| 3| 8| 1| 8| 2| 1| 2| 7| 3| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 | 27 1.3|
Inflammation, Suppurative | 1 | 3 1.3|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 1 1 2 1 1 1 1 1 1 1 1| 26 1.2|
Respiratory Epithelium, Epiglottis, | | |
Hyperplasia | 1 1 1 2 2 1 2 1 2 1 2 1 | 26 1.3|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 2 2 2 1 2 1 | 7 1.7|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 2 2 1 2 | 14 1.2|
Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 1 1 2 1 1 1 2 1| 21 1.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 2 3 1 1 1 3 2 2 2 2 1 1 3 2 2 2 3 2 2 2 3| 44 2.0|
Alveolus, Pigmentation | 1 | 8 1.3|
Bronchiole, Hyperplasia | 1 1 2 1 1 2 1 1 1 2 1| 14 1.3|
Interstitium, Fibrosis | 1 2 2 2 2 1 1 1 2 3 | 12 1.6|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Suppurative | 1 2 | 5 1.8|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 2 2 2 2 2 2 | 16 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 1 1 | 6 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 7| 7| 7| 6| 7| 6| 7| 4| 6| 6| 7| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 2| 3| 3| 6| 1| 5| 3| 3| 3| 3| 3| 9| 3| 9| 3| 2| 5| 1| 3| 9| 3| |
| 3| 0| 2| 2| 5| 3| 3| 1| 0| 2| 3| 9| 3| 1| 3| 8| 1| 8| 2| 1| 2| 7| 3| 9| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 2 |
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 1 2 1 1 1 1 1 1 | 20 1.3|
Cortex, Renal Tubule, Necrosis | 4 | 1 4.0|
Papilla, Mineralization | | 1 3.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 4| 3| 3| 4| 3| 3| 6| 1| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 9| 3| 8| 2| 1| 1| 0| 2| 2| 7| 3| 2| 8| 7| 5| 2| 2| 2| 1| 2| 1| 2| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + A + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + A + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + A + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | |
Hepatodiaphragmatic Nodule | X X X X X X X |
Vacuolization Cytoplasmic | 3 3 1 |
Bile Duct, Dilatation | 4 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Degeneration, Cystic | 2 |
Hepatocyte, Necrosis | 3 |
Portal, Inflammation, Chronic Active | 2 |
Portal, Pigmentation | 3 |
Serosa, Fibrosis | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Fat, Necrosis | 3 3 3 2 3 3 4 3 3 3 3|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 4| 3| 3| 4| 3| 3| 6| 1| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 9| 3| 8| 2| 1| 1| 0| 2| 2| 7| 3| 2| 8| 7| 5| 2| 2| 2| 1| 2| 1| 2| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Suppurative | 2 |
Ulcer | |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Necrosis | |
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 |
Necrosis | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 4| 3| 3| 4| 3| 3| 6| 1| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 9| 3| 8| 2| 1| 1| 0| 2| 2| 7| 3| 2| 8| 7| 5| 2| 2| 2| 1| 2| 1| 2| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cyst | 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 3 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 3 3 3 2 2 4 2 |
Inflammation, Chronic | 3 |
Granulosa Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Iliac, Ectasia | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + M + I + + +|
Pigmentation | 2 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + M + + + + M + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 4| 3| 3| 4| 3| 3| 6| 1| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 9| 3| 8| 2| 1| 1| 0| 2| 2| 7| 3| 2| 8| 7| 5| 2| 2| 2| 1| 2| 1| 2| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + I + + + + + + + M + + + + + + + + + + +|
Pigmentation | 1 1 1 1 1 1 1 2 1 1 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 1 2 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Ulcer | |
Hair Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 4| 3| 3| 4| 3| 3| 6| 1| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 9| 3| 8| 2| 1| 1| 0| 2| 2| 7| 3| 2| 8| 7| 5| 2| 2| 2| 1| 2| 1| 2| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Foreign Body | X |
Hemorrhage | |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 2 3 1 1 2 1 1 1 2 |
Inflammation, Suppurative | 2 3 |
Ulcer | |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 2 2 1 2 1 1 2 1 1 1 2 3 2 2 2 1 1 2 2 |
Respiratory Epithelium, Epiglottis, | |
Hyperplasia | 2 1 2 2 1 1 2 1 1 2 2 1 1 1 1 2 2 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 2 2 1 1 2 1 2 2 1 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 1 2 1 2 2 2 1 1 1 1 1 2 1|
Inflammation | |
Alveolar Epithelium, Hyperplasia | 3 3 3 3 3 4 4 3 3 4 2 4 3 3 3 3 3 3 3 3 3 3 3 2 4|
Alveolar Epithelium, Metaplasia, | |
Squamous | 2 4 2 |
Alveolar Epithelium, Regeneration | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 4 3 4 3 4 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3|
Alveolus, Pigmentation | 2 2 2 2 2 2 |
Bronchiole, Hyperplasia | 3 3 3 2 3 4 3 3 3 4 2 4 3 3 3 3 3 3 3 3 3 3 3 2 4|
Bronchiole, Metaplasia, Squamous | |
Interstitium, Fibrosis | 1 2 2 1 2 2 2 2 1 2 2 1 1 1 1 1 1 1 3|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 4 2 2 2 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 2 2 2 2 2 3 2 1 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 4 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1|
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 4| 3| 3| 4| 3| 3| 6| 1| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3|
| 1| 9| 3| 8| 2| 1| 1| 0| 2| 2| 7| 3| 2| 8| 7| 5| 2| 2| 2| 1| 2| 1| 2| 7| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Ulcer | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
|__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 1 1 1 1 2 1 2 3 3 2 1 2 1 2 1 |
Papilla, Mineralization | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 43
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + A + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + A + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + A + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.5|
Clear Cell Focus | X X X | 4 |
Clear Cell Focus, Multiple | X | 1 |
Hepatodiaphragmatic Nodule | X X X X X X | 13 |
Vacuolization Cytoplasmic | 4 1 2 2 | 7 2.3|
Bile Duct, Dilatation | | 1 4.0|
Bile Duct, Hyperplasia | | 1 2.0|
Hepatocyte, Degeneration, Cystic | | 1 2.0|
Hepatocyte, Necrosis | | 1 3.0|
Portal, Inflammation, Chronic Active | | 1 2.0|
Portal, Pigmentation | | 1 3.0|
Serosa, Fibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 15 |
Fat, Necrosis | 3 2 3 3 | 15 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 2 3.0|
Ulcer | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + + | 2 |
Epithelium, Hyperplasia | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 4 2 1 | 3 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 5 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 | 3 3.3|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 4 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 | 12 2.8|
Inflammation, Chronic | | 1 3.0|
Granulosa Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia | 3 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Iliac, Ectasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + M + + + + + + I + + + + + +| 44 |
Pigmentation | 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pigmentation | 1 3 1 1 1 1 1 1 1 2 1 1 1| 24 1.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 2 3.5|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 4 | 6 2.8|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 3| 1 3.0|
Ulcer | 3| 1 3.0|
Hair Follicle, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 | 1 4.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 2 2 1 2 2 2 2 1 2 1| 37 1.4|
Inflammation, Suppurative | | 2 2.5|
Ulcer | 2 | 1 2.0|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 1 1 1 1 1 1 1 2 1 1 1 2 1 2 2 2 2 2 1 1| 40 1.5|
Respiratory Epithelium, Epiglottis, | | |
Hyperplasia | 1 1 1 2 1 1 2 1 1 2 2 2 1 2 2 2 | 33 1.5|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 1 1 1 1 2 1 | 16 1.4|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 2 1 1 2 1 2 2 1 2 2 1| 40 1.7|
Inflammation | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 4 4 3 3 3 3 4 3 3 4 4 2 2 3 2 3 3 3 3 3 3 3 2 3 2| 50 3.1|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 4 3 3 | 6 3.0|
Alveolar Epithelium, Regeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 4 3 3 3 4 4 4 3 2 4 3 3 3 2 3 3 4 3 3 3 3 3 3 2| 50 3.1|
Alveolus, Pigmentation | 1 | 7 1.9|
Bronchiole, Hyperplasia | 4 3 3 3 3 4 3 3 4 4 2 2 3 2 3 3 3 3 3 3 2 3 2| 48 3.0|
Bronchiole, Metaplasia, Squamous | 2 | 1 2.0|
Interstitium, Fibrosis | 2 2 1 1 1 2 1 1 2 1 1 1 1 | 32 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Inflammation, Suppurative | 1 1 2 1 2 1 | 10 1.8|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 30 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 1 1 1| 7 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 | 4 1.0|
Respiratory Epithelium, Hyperplasia | 1 | 2 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
Respiratory Epithelium, Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens, Cataract | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 8| 3| 1| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 9| 1| 3| |
| 2| 3| 2| 5| 2| 0| 2| 9| 3| 4| 3| 5| 2| 3| 1| 1| 3| 6| 6| 3| 2| 3| 4| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 2 1 1 1 2 2 1 1 2 2 1| 32 1.7|
Papilla, Mineralization | 2 | 2 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 6| 6| 3|
DAY ON TEST | 3| 7| 1| 1| 2| 1| 3| 6| 9| 2| 5| 6| 3| 6| 8| 3| 8| 0| 2| 2| 3| 6| 1| 2| 7|
| 0| 7| 0| 7| 9| 2| 0| 1| 4| 9| 2| 6| 1| 6| 9| 0| 9| 8| 9| 9| 1| 6| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Hepatodiaphragmatic Nodule | X |
Vacuolization Cytoplasmic | 2 2 4 |
Bile Duct, Hyperplasia | 1 2 1 1 2 4 |
Hepatocyte, Regeneration | |
Portal, Inflammation, Chronic Active | 1 3 |
Serosa, Inflammation, Suppurative | |
|__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Fat, Necrosis | 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperkeratosis | 3 |
Inflammation, Suppurative | |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 6| 6| 3|
DAY ON TEST | 3| 7| 1| 1| 2| 1| 3| 6| 9| 2| 5| 6| 3| 6| 8| 3| 8| 0| 2| 2| 3| 6| 1| 2| 7|
| 0| 7| 0| 7| 9| 2| 0| 1| 4| 9| 2| 6| 1| 6| 9| 0| 9| 8| 9| 9| 1| 6| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 4 3 4 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Inflammation, Suppurative | |
Necrosis | |
|__________________________________________________________________________|
Tooth | + + + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 |
Atrium, Thrombosis | 2 |
Valve, Hemorrhage | 3 |
Ventricle, Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Necrosis | 4 |
Vacuolization Cytoplasmic | 2 2 2 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 4 4 1 4 3 1 |
Necrosis | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 6| 6| 3|
DAY ON TEST | 3| 7| 1| 1| 2| 1| 3| 6| 9| 2| 5| 6| 3| 6| 8| 3| 8| 0| 2| 2| 3| 6| 1| 2| 7|
| 0| 7| 0| 7| 9| 2| 0| 1| 4| 9| 2| 6| 1| 6| 9| 0| 9| 8| 9| 9| 1| 6| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 2 3 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
|__________________________________________________________________________|
Penis | |
Necrosis | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | |
Inflammation, Suppurative | 3 4 2 3 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 3 2 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 6| 6| 3|
DAY ON TEST | 3| 7| 1| 1| 2| 1| 3| 6| 9| 2| 5| 6| 3| 6| 8| 3| 8| 0| 2| 2| 3| 6| 1| 2| 7|
| 0| 7| 0| 7| 9| 2| 0| 1| 4| 9| 2| 6| 1| 6| 9| 0| 9| 8| 9| 9| 1| 6| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + + + + + + + + + M + M + M M + + M M M|
Pigmentation | 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + + M + + + + + + + M + + + + + + + + + M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + + + + + + + + + + + + + + + + + + + + + M|
Pigmentation | 2 1 1 2 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 2 2 3 4 |
Hematopoietic Cell Proliferation | 4 4 2 |
Hemorrhage | 4 3 |
Pigmentation | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Galactocele | 4 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperkeratosis | 3 4 |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 6| 6| 3|
DAY ON TEST | 3| 7| 1| 1| 2| 1| 3| 6| 9| 2| 5| 6| 3| 6| 8| 3| 8| 0| 2| 2| 3| 6| 1| 2| 7|
| 0| 7| 0| 7| 9| 2| 0| 1| 4| 9| 2| 6| 1| 6| 9| 0| 9| 8| 9| 9| 1| 6| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Necrosis | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 1 1 1 1 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 |
Inflammation, Chronic Active | 2 2 1 1 |
Alveolar Epithelium, Hyperplasia | 2 4 3 1 |
Alveolar Epithelium, Metaplasia, | |
Squamous | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 3 1 2 1 2 2 1 1 1 2 1 |
Alveolus, Pigmentation | |
Bronchiole, Hyperplasia | 4 2 |
Interstitium, Fibrosis | 2 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 3 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, | |
Mineralization | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 5| 6| 7| 6| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 6| 6| 3|
DAY ON TEST | 3| 7| 1| 1| 2| 1| 3| 6| 9| 2| 5| 6| 3| 6| 8| 3| 8| 0| 2| 2| 3| 6| 1| 2| 7|
| 0| 7| 0| 7| 9| 2| 0| 1| 4| 9| 2| 6| 1| 6| 9| 0| 9| 8| 9| 9| 1| 6| 7| 4| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | |
Atrophy | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 4 |
Nephropathy, Chronic | 3 3 3 4 2 1 1 1 1 4 3 2 2 4 1 2 3 1 2 4 |
Cortex, Cyst | 3 4|
Pelvis, Dilatation | |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 56
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + A + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + A + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A A + + + + + A + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + A + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A A + + + + + A + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 3 |
Hepatodiaphragmatic Nodule | X X X X | 5 |
Vacuolization Cytoplasmic | 4 4 | 5 3.2|
Bile Duct, Hyperplasia | 2 2 1 2 2 | 11 1.8|
Hepatocyte, Regeneration | 4 | 1 4.0|
Portal, Inflammation, Chronic Active | 1 2 | 4 1.8|
Serosa, Inflammation, Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + +| 8 |
Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 2 3 3 2| 7 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | X | 1 |
Hyperkeratosis | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Ulcer | | 3 3.7|
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 3 2| 2 2.5|
|__________________________________________________________________________|____________|
Tooth | + + +| 7 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 1 4 2| 7 2.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 | 7 1.4|
Atrium, Thrombosis | 3| 2 2.5|
Valve, Hemorrhage | | 1 3.0|
Ventricle, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 2 1 2 1 2| 9 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 2 2 3 1 1 2 1 1 2 | 16 2.1|
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 4 | 3 4.0|
Pars Distalis, Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 3 1 1 | 9 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Penis | + + | 2 |
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 4 3 2 | 3 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
Hyperplasia | 1 | 1 1.0|
Inflammation, Suppurative | 4 2 3 3 3 1 2| 12 2.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 4 4 | 6 3.5|
Interstitial Cell, Hyperplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + + + + + + + + + M + + + + +| 39 |
Pigmentation | 1 1 1 1 1 | 8 1.4|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + M + + + + + + + + + + + + + + + +| 45 |
Pigmentation | 2 1 2 1 1 2 2 1 1 1 1 1 | 17 1.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 3 3 3| 7 2.9|
Hematopoietic Cell Proliferation | 3 | 4 3.3|
Hemorrhage | 4 4 4 4 4 4 | 8 3.9|
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Galactocele | | 2 3.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 4.0|
Hyperkeratosis | 4 2| 4 3.3|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 3 4 3 | 5 3.0|
Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X X | 3 |
Inflammation, Chronic | 1 | 3 1.0|
Inflammation, Suppurative | 1 1 2 2 3 1| 11 1.5|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 4 2 | 5 2.8|
Inflammation, Chronic Active | 2 | 5 1.6|
Alveolar Epithelium, Hyperplasia | 4 1 1 | 7 2.3|
Alveolar Epithelium, Metaplasia, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Squamous | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 2 1 1 1 1 | 22 1.3|
Alveolus, Pigmentation | 2 | 1 2.0|
Bronchiole, Hyperplasia | 1 | 3 2.3|
Interstitium, Fibrosis | 2 2 1 | 7 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Foreign Body | X X | 3 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | 2 4 1 1 2 2 | 8 2.1|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 1 | 4 1.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 2 1 | 9 1.2|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.0|
Respiratory Epithelium, | | |
Mineralization | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 5| 6| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 8| 0| 6| 0| 5| 2| 3| 3| 2| 7| 6| 3| 0| 3| 2| 2| 2| 1| 0| 3| 2| 2| 2| 1| |
| 0| 9| 5| 6| 2| 0| 9| 6| 8| 9| 7| 9| 1| 8| 0| 9| 9| 9| 9| 1| 0| 9| 9| 8| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 4.0|
Nephropathy, Chronic | 2 2 1 2 3 2 2 2 4 2 4 1 2 3 4 3 3 | 37 2.4|
Cortex, Cyst | | 2 3.5|
Pelvis, Dilatation | 1 | 1 1.0|
Renal Tubule, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 7| 8| 3| 3| 3| 2| 2| 3| 0| 3| 3| 2| 7| 8| 3| 5| 2| 1| 3| 2| 9| 1| 2|
| 0| 2| 3| 4| 1| 0| 1| 9| 0| 1| 8| 0| 0| 9| 7| 5| 0| 2| 9| 6| 0| 9| 3| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Vacuolization Cytoplasmic | 1 3 |
Bile Duct, Hyperplasia | 1 2 1 2 2 1|
Hepatocyte, Degeneration, Cystic | 4 |
Hepatocyte, Necrosis | 4 |
Hepatocyte, Regeneration | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Hemorrhage | 3 |
Fat, Hemorrhage | |
Fat, Necrosis | 2 3 3 3 2 4 3 3 3 3 3|
|__________________________________________________________________________|
Oral Mucosa | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 7| 8| 3| 3| 3| 2| 2| 3| 0| 3| 3| 2| 7| 8| 3| 5| 2| 1| 3| 2| 9| 1| 2|
| 0| 2| 3| 4| 1| 0| 1| 9| 0| 1| 8| 0| 0| 9| 7| 5| 0| 2| 9| 6| 0| 9| 3| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 3 |
Arteriole, Necrosis | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Vacuolization Cytoplasmic | 1 1 1 4 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hemorrhage | |
Pars Distalis, Hyperplasia | 4 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 7| 8| 3| 3| 3| 2| 2| 3| 0| 3| 3| 2| 7| 8| 3| 5| 2| 1| 3| 2| 9| 1| 2|
| 0| 2| 3| 4| 1| 0| 1| 9| 0| 1| 8| 0| 0| 9| 7| 5| 0| 2| 9| 6| 0| 9| 3| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Suppurative | 1 2 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Necrosis | 4 |
Germinal Epithelium, Atrophy | 4 3 4 |
Interstitial Cell, Hyperplasia | 3 2 2 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + M + + + + + + + + + + + + I + + M|
Fibrosis | 2 |
Pigmentation | 2 1 1 1 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Acute | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + I +|
Pigmentation | 2 2 2 1 1 1 2 1 1 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 7| 8| 3| 3| 3| 2| 2| 3| 0| 3| 3| 2| 7| 8| 3| 5| 2| 1| 3| 2| 9| 1| 2|
| 0| 2| 3| 4| 1| 0| 1| 9| 0| 1| 8| 0| 0| 9| 7| 5| 0| 2| 9| 6| 0| 9| 3| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Fibrosis | 2 2 4 4 4 2 3 3 |
Hemorrhage | |
Necrosis | 4 4 |
Pigmentation | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperkeratosis | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 4 |
Hydrocephalus | |
Necrosis | |
Medulla, Demyelination, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 1 2 |
Inflammation, Suppurative | |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 7| 8| 3| 3| 3| 2| 2| 3| 0| 3| 3| 2| 7| 8| 3| 5| 2| 1| 3| 2| 9| 1| 2|
| 0| 2| 3| 4| 1| 0| 1| 9| 0| 1| 8| 0| 0| 9| 7| 5| 0| 2| 9| 6| 0| 9| 3| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Epiglottis, | |
Hyperplasia | 2 1 1 2 2 1 2 1 1 2 2 2 |
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 2 1 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 2 2 3 1 2 |
Inflammation, Suppurative | |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 4 2 3 1 1 1 2 1 3 1 2 2 1 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 3 2 2 1 3 2 2 1 1 2 3 2 2 2 1 2 2 2|
Bronchiole, Hyperplasia | 4 2 3 1 3 2 1 2|
Interstitium, Fibrosis | 2 4 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 1 1 3 2 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 7| 8| 3| 3| 3| 2| 2| 3| 0| 3| 3| 2| 7| 8| 3| 5| 2| 1| 3| 2| 9| 1| 2|
| 0| 2| 3| 4| 1| 0| 1| 9| 0| 1| 8| 0| 0| 9| 7| 5| 0| 2| 9| 6| 0| 9| 3| 4| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + |
Atrophy | 1 |
Lens, Cataract | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy, Chronic | 2 2 2 1 1 2 1 2 2 3 4 4 1 2 4 2 4 3 1 1 2 1 3|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
__________________________________________|__________________________________________________________________________
Page 69
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X| 2 |
Hepatodiaphragmatic Nodule | X X X X | 8 |
Vacuolization Cytoplasmic | 2 2 | 4 2.0|
Bile Duct, Hyperplasia | 2 2 | 8 1.6|
Hepatocyte, Degeneration, Cystic | 1 1 | 3 2.0|
Hepatocyte, Necrosis | | 1 4.0|
Hepatocyte, Regeneration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 18 |
Hemorrhage | | 1 3.0|
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 3 3 3 3 3 | 16 2.9|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Ulcer | 4 3 | 3 3.3|
Arteriole, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 | 7 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Vacuolization Cytoplasmic | 1 | 5 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2| 8 2.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 3 3 3 | 5 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 1.5|
Inflammation, Suppurative | 2 2 2 1 2 | 8 1.9|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Necrosis | | 1 4.0|
Germinal Epithelium, Atrophy | 4 4 4 | 6 3.8|
Interstitial Cell, Hyperplasia | 1 2 | 7 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 3 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M + + + + M| 44 |
Fibrosis | | 1 2.0|
Pigmentation | 2 1 | 8 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + M + + + + +| 47 |
Pigmentation | 1 1 1 1 2| 15 1.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 4 3 2 3 3 2 | 16 2.9|
Hemorrhage | 4 4 3 3 | 4 3.5|
Necrosis | | 2 4.0|
Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4| 1 4.0|
Hyperkeratosis | 3 2| 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2| 3 3.3|
Hydrocephalus | 4 | 1 4.0|
Necrosis | 2 | 1 2.0|
Medulla, Demyelination, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X| 3 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 | 20 1.1|
Inflammation, Suppurative | 2 2 3| 3 2.3|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 1 1 1 1 1 1 2 1 2 1 1 1 | 22 1.1|
Respiratory Epithelium, Epiglottis, | | |
Hyperplasia | 1 1 2 1 1 2 | 18 1.5|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 2 2 1 2 2| 9 1.7|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 1 2 | 8 1.8|
Inflammation, Suppurative | 4 3 | 2 3.5|
Mineralization | 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 3 3 1 4 1 1 4 2 2 | 24 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 2 4 2 2 4 2 1 2 2 1 2 3 2 2 2 1 1 1| 40 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Bronchiole, Hyperplasia | 2 3 3 1 4 1 1 2 2 | 17 2.2|
Interstitium, Fibrosis | 1 2 3 | 7 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 5 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 4 1 2 | 7 2.0|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 1 2 3 1 2 2 1 1 | 15 1.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 2 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 | 3 1.7|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 1 | 3 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X| 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | +| 3 |
Atrophy | | 1 1.0|
Lens, Cataract | 2| 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 4.0|
Nephropathy, Chronic | 3 2 2 2 2 2 2 1 1 3 4 1 3 2 1 3 1 2 3| 42 2.1|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 0| 3| 2| 2| 4| 8| 2| 5| 3| 2| 2| 2| 3| 2| 7| 9| 2| 1| 3| 3| 0| 3| 0| |
| 4| 0| 8| 0| 9| 9| 8| 0| 9| 3| 1| 9| 9| 9| 0| 9| 1| 4| 9| 1| 0| 0| 8| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.5 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 3| 6| 7| 6| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 1| 2| 3| 6| 2| 2| 1| 3| 2| 3| 9| 3| 3| 7| 5| 8| 2| 1| 9| 2| 8|
| 0| 1| 0| 9| 2| 9| 1| 1| 9| 9| 7| 3| 8| 0| 2| 3| 0| 1| 3| 4| 2| 2| 4| 5| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + A + + + + + +|
Thrombosis | 3 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + A A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + A A + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + A A + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Vacuolization Cytoplasmic | 3 4 4 2 2 |
Bile Duct, Hyperplasia | 2 2 1|
Hepatocyte, Degeneration, Cystic | 4 4 |
Hepatocyte, Necrosis | 3 |
Hepatocyte, Regeneration | 4 |
Portal, Inflammation, Chronic Active | 1|
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Hemorrhage | 2 |
Fat, Necrosis | 2 3 2 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 2 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 3| 6| 7| 6| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 1| 2| 3| 6| 2| 2| 1| 3| 2| 3| 9| 3| 3| 7| 5| 8| 2| 1| 9| 2| 8|
| 0| 1| 0| 9| 2| 9| 1| 1| 9| 9| 7| 3| 8| 0| 2| 3| 0| 1| 3| 4| 2| 2| 4| 5| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Necrosis | 3 1 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 1 |
Atrium, Thrombosis | 4 |
Pericardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 4 2 4 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 4 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 3| 6| 7| 6| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 1| 2| 3| 6| 2| 2| 1| 3| 2| 3| 9| 3| 3| 7| 5| 8| 2| 1| 9| 2| 8|
| 0| 1| 0| 9| 2| 9| 1| 1| 9| 9| 7| 3| 8| 0| 2| 3| 0| 1| 3| 4| 2| 2| 4| 5| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
C-Cell, Hyperplasia | 2 2 3 4 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | 3 |
|__________________________________________________________________________|
Penis | + |
Hyperplasia, Squamous | |
Necrosis | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 2 4 2 3|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | 2 2 |
Germinal Epithelium, Atrophy | 2 3 4 4 4 3|
Interstitial Cell, Hyperplasia | 2 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 3| 6| 7| 6| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 1| 2| 3| 6| 2| 2| 1| 3| 2| 3| 9| 3| 3| 7| 5| 8| 2| 1| 9| 2| 8|
| 0| 1| 0| 9| 2| 9| 1| 1| 9| 9| 7| 3| 8| 0| 2| 3| 0| 1| 3| 4| 2| 2| 4| 5| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Ectasia | 3 |
Inflammation, Acute | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + M + + + + M + + + + + + + + + + + +|
Pigmentation | 2 1 1 2 1 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 2 3 2 3 3 3 2 2|
Hemorrhage | 4 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Cyst, Multiple | |
Hyperkeratosis | 3 3 2|
Hyperplasia | |
Inflammation, Acute | |
Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis | |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 3| 6| 7| 6| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 1| 2| 3| 6| 2| 2| 1| 3| 2| 3| 9| 3| 3| 7| 5| 8| 2| 1| 9| 2| 8|
| 0| 1| 0| 9| 2| 9| 1| 1| 9| 9| 7| 3| 8| 0| 2| 3| 0| 1| 3| 4| 2| 2| 4| 5| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3|
|__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hyperkeratosis | 2 |
Inflammation, Chronic | 1 1 1 2 3 1 1 2 2 2 2 1 |
Inflammation, Suppurative | 4 2 2 2 |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 1 1 1 1 1 1 2 1 1 1 1|
Respiratory Epithelium, Epiglottis, | |
Hyperplasia | 1 1 1 1 2 3 1 2 2 2 2 1 2 2 1 2 1 2 2 1|
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 2 2 2 2 2 3 1 2 1|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 1 2 2 1 1 1 1 2 1 2 2 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 3 2 2 2 2 2 2 4 1 2 2 2 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 3 3 2 3 2 2 3 3 2 4 3 2 2 2 2 3 2 3 1 2|
Alveolus, Pigmentation | 2 1 |
Bronchiole, Hyperplasia | 2 3 2 2 2 2 2 2 4 1 2 2 4 |
Interstitium, Edema | |
Interstitium, Fibrosis | 2 1 2 1 3 2 1 2 1 1 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 3| 6| 7| 6| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 1| 2| 3| 6| 2| 2| 1| 3| 2| 3| 9| 3| 3| 7| 5| 8| 2| 1| 9| 2| 8|
| 0| 1| 0| 9| 2| 9| 1| 1| 9| 9| 7| 3| 8| 0| 2| 3| 0| 1| 3| 4| 2| 2| 4| 5| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Foreign Body | |
Inflammation, Suppurative | 1 |
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 2 2 1 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Pleura | |
Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Lens, Cataract | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lipocyte | 4 |
Nephropathy, Chronic | 3 2 2 4 2 3 2 4 4 1 1 1 3 2 4 2 2 1 4 3 3 1 2|
Renal Tubule, Pigmentation | 4 |
|__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 82
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Thrombosis | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + A + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | | 1 |
Hepatodiaphragmatic Nodule | X X X X | 7 |
Vacuolization Cytoplasmic | 1 3 2 | 8 2.6|
Bile Duct, Hyperplasia | 1 1 1 2 2 | 8 1.5|
Hepatocyte, Degeneration, Cystic | | 2 4.0|
Hepatocyte, Necrosis | | 1 3.0|
Hepatocyte, Regeneration | 3 | 2 3.5|
Portal, Inflammation, Chronic Active | | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 12 |
Hemorrhage | | 1 2.0|
Fat, Necrosis | 3 2 2 3 | 9 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 | 4 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 4 | 4 3.5|
Epithelium, Hyperplasia | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 2.0|
Necrosis | | 2 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Heart | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 2 1 2 | 7 1.6|
Atrium, Thrombosis | 3 | 2 3.5|
Pericardium, Fibrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Vacuolization Cytoplasmic | 2 2 | 7 2.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 3 4 1 4 4 4 | 12 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 3 3 3 | 5 3.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | | 4 2.8|
Follicular Cell, Hyperplasia | 2 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Spermatocele | | 1 3.0|
|__________________________________________________________________________|____________|
Penis | + + | 3 |
Hyperplasia, Squamous | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Prostate | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 | 3 1.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 2 2 4 4| 8 2.9|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Seminal Vesicle | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 4| 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation | | 2 2.0|
Germinal Epithelium, Atrophy | 4 4 4 3 4 4 4 | 13 3.6|
Interstitial Cell, Hyperplasia | 3 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + A + + + + + + + + + + + + + + + + + + + + I +| 47 |
Pigmentation | 1 | 3 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + A + + + + + + + + + + + + + + + + + + + + M +| 46 |
Ectasia | | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 |
Pigmentation | 2 1 1 1 1 2 2 2 2 2 2 | 17 1.5|
|__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Spleen | X | 1 |
Fibrosis | 2 4 3 1 | 12 2.5|
Hemorrhage | | 1 4.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | 2 2 3 | 5 2.6|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Cyst, Multiple | 4 | 1 4.0|
Hyperkeratosis | | 3 2.7|
Hyperplasia | 2 | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Fibrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | 1 1 2 1 1| 17 1.5|
Inflammation, Suppurative | | 4 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 2 1 1 1 1 1 1 1 1 1 1 | 23 1.1|
Respiratory Epithelium, Epiglottis, | | |
Hyperplasia | 1 1 1 1 1 3 1 1 1 1 1 1 2 2| 34 1.5|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 2 3 1 1 1 1 2| 16 1.8|
|__________________________________________________________________________|____________|
Lung | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 2 | 2 2.0|
Inflammation, Chronic Active | 2 2 1 1 1 1 1 2 1 1 | 24 1.3|
Alveolar Epithelium, Hyperplasia | 2 2 2 1 2 1 4 1 2 1 2 4 2 3 1 1 1 1 1 1 | 34 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 2 2 2 2 2 2 2 3 2 3 2 2 2 3 2 2 2 2 2| 45 2.3|
Alveolus, Pigmentation | | 2 1.5|
Bronchiole, Hyperplasia | 1 2 1 2 1 1 1 1 4 2 2 1 1 1 1 1 1 1 | 31 1.8|
Interstitium, Edema | 2 | 1 2.0|
Interstitium, Fibrosis | 2 2 1 2 1 | 16 1.6|
|__________________________________________________________________________|____________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X | 1 |
Inflammation, Suppurative | 2 2 | 3 1.7|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 3 2 2 2 2 2 | 12 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pleura | + + | 2 |
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 0| 2| 2| 2| 0| 3| 3| 2| 3| 5| 3| 3| 2| 9| 2| 3| 5| 8| 3| 2| 2| 2| 6| |
| 9| 9| 3| 9| 9| 9| 8| 0| 0| 9| 0| 5| 0| 0| 8| 8| 9| 0| 1| 0| 1| 9| 9| 9| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
1.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 2 |
Lens, Cataract | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lipocyte | | 1 4.0|
Nephropathy, Chronic | 1 1 2 2 3 4 1 1 1 1 3 1 2 1 1 2 2 2 1 1 2 3 4| 46 2.1|
Renal Tubule, Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Calculus Micro Observation Only | X | 1 |
Hemorrhage | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + A + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Bile Stasis | |
Clear Cell Focus | X X X X|
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 3 2 |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 2 2 2 2 3 |
Portal, Inflammation, Chronic Active | |
Portal, Pigmentation | 4 |
|__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation | |
Fat, Necrosis | 3 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Inflammation, Suppurative | 2 |
Pharyngeal, Hyperplasia, Squamous | 4 |
Pharyngeal, Ulcer | 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 2 3|
Artery, Inflammation | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4|
Diverticulum | X |
Inflammation, Suppurative | |
Necrosis | |
Ulcer | 4 2 |
Epithelium, Hyperplasia | 4|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Tooth | + + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Thrombosis | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hyperplasia | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 1|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 |
Inflammation, Suppurative | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Germinal Epithelium, Atrophy | 3 4 4 4 4 |
Interstitial Cell, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node | + + + |
Inflammation, Granulomatous | |
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M + + + + + + + + + + + + + + + + + + + M + + +|
Pigmentation | 1 1 2 1 2 1 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + M + + + M + + + + + + + + + +|
Angiectasis | |
Inflammation, Granulomatous | 4 3 |
Pigmentation | 1 1 2 1 3 2 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 1 3 3 3 2 4 |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Hyperkeratosis | 4 4 |
Hair Follicle, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 4 |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + A + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 2 1 1 1 1 1 2 2 3 1 1 4 1 1|
Inflammation, Suppurative | 1 2 2 2 1 1 3 4 |
Respiratory Epithelium, Ulcer | |
Respiratory Epithelium, Epiglottis, | |
Degeneration | 1 2 1 2 2 1 1 2 2 1 2 1 1 1 2 1 1|
Respiratory Epithelium, Epiglottis, | |
Hyperplasia | 2 2 1 2 2 1 1 3 2 1 1|
Respiratory Epithelium, Epiglottis, | |
Metaplasia, Squamous | 1 1 1 2 2 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 2 2 3 2 2 2 2 3 3 3 2 2 2 2 3 2 2 3 2 3|
Metaplasia | |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 3 2 4 3 3 3 3 4 4 3 3 4 4 3 2 3 3 4 2 3 3 4 3 3 4|
Alveolar Epithelium, Metaplasia, | |
Squamous | 4 2 4 4 4 4 4 4 4 4 4 4|
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 3 4 3 3 2 3 3 3 3 3 4 4 3 2 3 3 4 3 2 3 4 3 3 4|
Alveolus, Pigmentation | 2 2 1 2 2 2 2 1 2 2 3 2|
Artery, Mineralization | 3 |
Bronchiole, Hyperplasia | 3 2 4 3 3 3 3 4 4 3 3 4 4 3 2 3 3 4 2 2 3 4 3 3 4|
Bronchiole, Metaplasia, Squamous | 4 4 |
Interstitium, Fibrosis | 2 1 2 2 2 1 2 3 2 2 2 4 1 2 1 2 3|
Mediastinum, Hemorrhage | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 3 2 2 4 1 2 1|
Goblet Cell, Respiratory Epithelium, | |
Hyperplasia | 2 3 2 2 2 2 2 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Respiratory Epithelium, Hyperplasia | 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
|__________________________________________________________________________|
Pleura | + |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | +|
Atrophy | |
Lens, Cataract | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Nephropathy, Chronic | 2 2 3 2 3 2 3 1 2 3 3 3 2 2 1 1 2 1 3 2 2 1 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 5| 3| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 9| 3| 2| 5| 9| 3| 2| 3| 2| 3| 2| 3| 5| 2| 3| 6| 3| 4| 3| 1| 3| 8| 2|
| 0| 2| 5| 0| 9| 8| 0| 1| 3| 3| 9| 0| 9| 1| 2| 9| 1| 1| 6| 2| 0| 2| 0| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation | 3 |
Transitional Epithelium, Hyperplasia | 4 |
__________________________________________|__________________________________________________________________________
Page 96
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + A + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + A + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + A + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + A + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + A + A A| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + A + + A| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Bile Stasis | 3 | 1 3.0|
Clear Cell Focus | X X X | 7 |
Hepatodiaphragmatic Nodule | X X X X X X X X X | 14 |
Inflammation, Granulomatous | 1 3 | 2 2.0|
Mixed Cell Focus | | 1 |
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 3 4 | 5 2.8|
Bile Duct, Dilatation | 4 | 1 4.0|
Bile Duct, Hyperplasia | 2 1 2 1 3 2 2 1 3 | 14 2.0|
Portal, Inflammation, Chronic Active | 3 2 1 1 | 4 1.8|
Portal, Pigmentation | 4 2 | 3 3.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + +| 9 |
Artery, Inflammation | 4| 1 4.0|
Fat, Necrosis | 3 3 2 4 3 | 8 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Suppurative | | 1 2.0|
Pharyngeal, Hyperplasia, Squamous | | 1 4.0|
Pharyngeal, Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lipocyte | 3 | 1 3.0|
Acinus, Atrophy | 3 | 1 3.0|
Acinus, Hyperplasia | | 3 2.3|
Artery, Inflammation | 4| 2 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Diverticulum | X | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Ulcer | 3 | 3 3.0|
Epithelium, Hyperplasia | 2 | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 2 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + | 5 |
Peridontal Tissue, Inflammation, | | |
Suppurative | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 | 7 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | | 1 2.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 4 2 | 5 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 2 4 4 3 | 10 2.7|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 4 4 | 4 3.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 2 4 | 6 2.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 3.0|
Inflammation, Suppurative | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 3 4 4 4 4 | 10 3.8|
Interstitial Cell, Hyperplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Inflammation, Granulomatous | 3 | 1 3.0|
Pancreatic, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + M + + + + + + + + + + + + + + + +| 44 |
Pigmentation | 3 1 2 1 2 | 12 1.6|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + M + + + + + + + + + + M + + + + M| 45 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Acute | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + I + + + M + + + + + + + + + + + + + + M +| 44 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Angiectasis | 4 | 1 4.0|
Inflammation, Granulomatous | | 2 3.5|
Pigmentation | 2 3 2 2 2 2 1 1 2| 17 1.8|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 2 3 2 | 11 2.7|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 1 4| 4 2.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 4 4| 6 3.8|
Hyperkeratosis | 2 | 3 3.3|
Hair Follicle, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 2 | 4 3.5|
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X| 2 |
Inflammation, Chronic | 2 2 2 2 1 1 1 2 2 2 1 1 1 4| 28 1.6|
Inflammation, Suppurative | 1 1 2 3 4| 13 2.1|
Respiratory Epithelium, Ulcer | 3 | 1 3.0|
Respiratory Epithelium, Epiglottis, | | |
Degeneration | 1 1 2 2 2 2 2 2 2 2 2 1 1 2 1 2 | 33 1.5|
Respiratory Epithelium, Epiglottis, | | |
Hyperplasia | 2 1 1 3 3 2 2 3 1 1 1 2 2 2 3 2 1 3 1 2 4| 32 1.9|
Respiratory Epithelium, Epiglottis, | | |
Metaplasia, Squamous | 2 1 4 2 1 3 3 2 2 2 2 3 4| 19 2.1|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 2 3 2 3 3 3 2 2 2 3 2 3 2 2 2 3 3 2 2 3 2 2| 42 2.4|
Metaplasia | 1 | 1 1.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 4 4 3 4 4 4 4 2 3 3 3 4 4 3 3 3 4 3 3 3 4 3 4| 49 3.3|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 4 4 4 4 4 2 1 2 4| 21 3.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 3 4 3 4 4 4 4 3 3 3 3 4 4 4 3 3 3 4 3 3 4 4 3 4| 50 3.3|
Alveolus, Pigmentation | 2 2 2 3 3 1 2 3 3 2 2 2 1 2 3 2 | 28 2.1|
Artery, Mineralization | | 1 3.0|
Bronchiole, Hyperplasia | 3 3 4 3 4 4 4 4 3 2 3 3 4 4 3 3 3 4 3 3 3 4 3 4| 49 3.3|
Bronchiole, Metaplasia, Squamous | 4 4 4 4 2 | 7 3.7|
Interstitium, Fibrosis | 1 1 3 2 2 3 4 3 1 2 1 2 2 4 2 3 2 3 1 3 2| 38 2.1|
Mediastinum, Hemorrhage | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + A + + + + + + + + + + + + A + + +| 48 |
Foreign Body | | 1 |
Inflammation, Suppurative | 4 2 2 1 | 11 2.2|
Goblet Cell, Respiratory Epithelium, | | |
Hyperplasia | 2 3 2 2 2 2 2 2 | 17 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 61427-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VANADIUM PENTOXIDE Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:04
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 5| 6| |
DAY ON TEST | 7| 6| 3| 2| 8| 3| 2| 3| 4| 3| 3| 2| 3| 2| 3| 2| 2| 2| 3| 3| 7| 1| 3| 3| 8| |
| 5| 1| 0| 9| 4| 1| 9| 0| 2| 0| 0| 9| 0| 9| 0| 9| 3| 9| 0| 0| 8| 6| 0| 8| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
2.0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 | 4 1.3|
Respiratory Epithelium, Hyperplasia | 4 | 3 3.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Pleura | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 3 |
Atrophy | 4 | 1 4.0|
Lens, Cataract | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 4 | 1 4.0|
Nephropathy, Chronic | 2 2 3 2 4 2 1 2 2 4 2 3 2 3 2 4 3 3 3 1 3 3 1 4| 47 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
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---------- END OF REPORT ----------
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