TDMS Study 61427-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 07 TIME: 10:14:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: RENNE, ROGER MILLER, RODNEY CAS: 1314-62-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#2/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 07 TIME: 10:14:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: RENNE, ROGER MILLER, RODNEY CAS: 1314-62-1
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 373 477 502 561 589 589 589 610 612 617 |
| 617 619 624 628 636 638 650 652 666 666 |
| 666 666 669 677 694 701 705 708 708 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 311 353 485 493 548 571 584 608 620 652 |
| 652 673 677 680 684 694 708 708 709 714 |
| 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 392 519 528 551 584 633 633 653 655 661 |
| 661 671 680 684 694 698 703 708 712 712 |
| 717 722 725 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 332 390 533 538 542 552 558 561 578 616 |
| 623 629 631 636 642 661 675 684 685 687 |
| 695 712 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 86.0 64.0 40.0 |
| | |
| | |
|0.5 | 100.0 100.0 100.0 96.0 96.0 94.0 92.0 86.0 78.0 58.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 78.0 52.0 |
|MG/M3 | |
| | |
|2.0 | 100.0 100.0 100.0 98.0 96.0 96.0 90.0 82.0 68.0 54.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.5 1.0 2.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 40.0% 58.0% 52.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.386N P=0.085N P=0.138N P=0.289N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 627.3 611.4 651.0 603.6 |
|NATURAL DEATHS (C) | (13.6) (25.4) (16.8) (20.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 668.0 679.6 691.6 671.3 |
|(STANDARD ERROR) | (10.8) (13.4) ( 9.7) (12.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 234 458 463 519 548 624 625 638 638 638 |
| 666 666 698 708 717 720 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 366 408 499 533 540 571 571 582 608 612 |
| 633 652 667 668 675 694 695 696 701 708 |
| 710 712 717 717 717 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 139 421 433 499 570 572 589 617 638 652 |
| 652 661 680 683 689 698 698 707 710 712 |
| 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 332 440 455 514 569 589 597 612 617 636 |
| 638 647 653 668 680 694 706 715 717 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VANADIUM PENTOXIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 94.0 92.0 90.0 80.0 66.0 |
| | |
| | |
|0.5 | 100.0 100.0 100.0 100.0 96.0 96.0 90.0 84.0 76.0 48.0 |
|MG/M3 | |
| | |
|1.0 | 100.0 98.0 98.0 98.0 96.0 94.0 92.0 86.0 76.0 58.0 |
|MG/M3 | |
| | |
|2.0 | 100.0 100.0 100.0 98.0 98.0 94.0 92.0 86.0 74.0 60.0 |
|MG/M3 | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.5 1.0 2.0 |
| MG/M3 MG/M3 MG/M3 |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 48.0% 58.0% 60.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.917 P=0.119 P=0.522 P=0.621 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.8 629.8 606.9 610.2 |
|NATURAL DEATHS (C) | (30.9) (19.1) (30.3) (23.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 688.1 678.4 678.9 682.7 |
|(STANDARD ERROR) | (13.4) (12.2) (15.3) (12.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VANADIUM PENTOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.5 MG/M3 = 2
1.0 MG/M3 = 3
2.0 MG/M3 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 1 3
| 2 4 2 1 3 1 3
| 2 4 1221 334 3 1
| 2 442 1 3 1
P 90 + 42 2 3 3
E | 44 2 2
R | 44 42 1 212 3 3
C | 4 11 2 3
E 80 + 44
N | 44 2 332
T | 114 322
| 114 3 3
S 70 + 11 4 2 2
U | 11 4 4 232
R | 11 144 33
V | 44
I 60 + 44 22
V | 4 423 2
A | 11 4 4 4
L | 1 1 3 3
50 + 11
|
| 11
|
40 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 24 obs hidden.
VANADIUM PENTOXIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.5 MG/M3 = 2
1.0 MG/M3 = 3
2.0 MG/M3 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
| 3 1 4 2 2 3 4 1
| 2 334 411 2 4 1 2
| 3 4 1 221 3
P 90 + 21 2 4 1
E | 3 34
R | 2 2 342431 1
C | 224 43 3
E 80 + 2 21 1
N | 2442 3
T | 42 31 3 1 1
| 2233 11
S 70 + 2432
U | 44 11
R | 22341 1
V | 2244
I 60 + 3 3 4
V | 3 3
A | 22
L |
50 + 22
| 2 2
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 33 obs hidden.