TDMS Study 61427-08 Pathology Tables
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
FINAL#2/MICE
Facility: Battelle Northwest
Chemical CAS #: 1314-62-1
Lock Date: 11/02/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 8 10 14 16
Natural Death 4 5 4 2
Accidently Killed 3 2
Survivors
Terminal Sacrifice 38 32 29 32
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (41) (43) (45)
Inflammation, Suppurative 1 [1.0] 1 [1.0]
Intestine Small, Duodenum (47) (43) (46) (49)
Inflammation, Suppurative 1 [1.0] 1 [2.0]
Ulcer 1 [2.0]
Epithelium, Hyperplasia 1 [2.0]
Intestine Small, Jejunum (47) (43) (45) (50)
Inflammation 1 [3.0]
Intestine Small, Ileum (47) (43) (46) (50)
Inflammation, Suppurative 1 [3.0] 1 [2.0]
Ulcer 1 [2.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [1.0] 1 [4.0]
Basophilic Focus 1
Clear Cell Focus 1
Eosinophilic Focus 12 12 3 8
Eosinophilic Focus, Multiple 4 2 1
Fatty Change 1 [4.0]
Hematopoietic Cell Proliferation 4 [1.8] 6 [2.0] 3 [1.3]
Infiltration Cellular, Mixed Cell 1 [3.0]
Inflammation, Focal, Granulomatous 12 [1.0] 26 [1.0] 19 [1.1] 21 [1.0]
Necrosis, Focal 2 [1.5] 6 [1.2] 9 [1.6] 5 [1.2]
Pigmentation, Hemosiderin 1 [2.0] 2 [2.0]
Tension Lipidosis 2 4 1 2
Bile Duct, Cyst 1 [2.0] 1 [1.0] 1 [3.0]
Centrilobular, Degeneration 1 [3.0]
Centrilobular, Inflammation, Chronic 1 [2.0]
Centrilobular, Necrosis 1 [1.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (14) (9) (5) (4)
Hemorrhage 1 [4.0]
Artery, Inflammation 1 [2.0]
Fat, Inflammation 1 [2.0] 1 [3.0] 1 [2.0]
Fat, Necrosis 11 [2.9] 9 [2.6] 5 [1.8] 3 [2.7]
Pancreas (50) (50) (49) (50)
Atrophy 3 [2.3] 4 [2.0] 2 [1.0] 4 [1.5]
Duct, Cyst 1 [4.0]
Salivary Glands (50) (50) (50) (50)
Amyloid Deposition 1 [1.0]
Stomach, Forestomach (50) (50) (50) (50)
Cyst 2 [2.5]
Inflammation, Suppurative 1 [1.0] 1 [4.0]
Mineralization 1 [1.0]
Ulcer 1 [1.0] 1 [1.0] 2 [1.5] 1 [1.0]
Epithelium, Hyperplasia 3 [2.0] 1 [1.0] 7 [2.3] 1 [2.0]
Stomach, Glandular (49) (47) (48) (50)
Inflammation, Suppurative 1 [2.0] 1 [1.0]
Mineralization 1 [1.0]
Ulcer 1 [2.0] 1 [1.0] 1 [1.0]
Epithelium, Hyperplasia 1 [1.0]
Tooth (1)
Malformation 1
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 47 [1.1] 45 [1.1] 46 [1.1] 49 [1.1]
Inflammation 1 [2.0]
Mineralization 2 [1.5] 1 [1.0] 1 [1.0]
Artery, Inflammation 1 [1.0]
Capillary, Hyperplasia 2 [2.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (49)
Degeneration, Cystic 2 [1.5] 2 [2.0]
Hypertrophy 5 [1.0] 5 [1.2] 3 [1.0] 7 [1.0]
Capsule, Hyperplasia 1 [3.0]
Adrenal Medulla (49) (50) (48) (49)
Hyperplasia 4 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 1 [1.0]
Parathyroid Gland (42) (41) (43) (39)
Cyst 1 [2.0]
Hyperplasia 2 [2.5] 1 [1.0]
Pituitary Gland (49) (50) (50) (47)
Pars Distalis, Cyst 2 [1.5] 1 [1.0] 2 [1.5]
Pars Distalis, Hyperplasia 22 [2.0] 26 [1.5] 15 [1.9] 20 [1.6]
Thyroid Gland (50) (50) (48) (50)
Inflammation, Suppurative 2 [1.0]
Follicular Cell, Cyst 1 [2.0] 1 [3.0]
Follicular Cell, Hyperplasia 1 [1.0] 1 [1.0] 1 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (50) (49) (47)
Angiectasis 1 [2.0] 1 [2.0] 1 [2.0] 1 [1.0]
Cyst 16 [1.7] 16 [2.4] 15 [2.1] 17 [2.1]
Hemorrhage 1 [4.0]
Thrombosis 1 [4.0] 1 [4.0]
Uterus (50) (49) (49) (50)
Angiectasis 5 [3.0] 4 [2.5] 1 [3.0]
Hyperplasia, Cystic 46 [2.8] 43 [2.2] 42 [2.2] 41 [2.7]
Inflammation 1 [2.0]
Inflammation, Focal 1 [2.0]
Thrombosis 1 [3.0]
Myometrium, Hyperplasia 1 [3.0]
Serosa, Fibrosis 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 5 [2.0] 1 [2.0] 6 [2.2] 6 [1.8]
Lymph Node (3) (1) (5) (1)
Angiectasis 3 [3.0] 1 [3.0]
Lymph Node, Bronchial (39) (40) (45) (41)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 3 [2.0] 13 [1.8] 14 [2.3] 20 [2.3]
Lymph Node, Mandibular (41) (40) (40) (46)
Hyperplasia 2 [3.0] 1 [3.0] 3 [2.3]
Lymph Node, Mesenteric (46) (47) (48) (50)
Angiectasis 1 [2.0]
Hyperplasia 2 [2.0] 1 [2.0] 1 [2.0] 1 [2.0]
Lymph Node, Mediastinal (43) (37) (42) (42)
Hyperplasia 6 [2.2] 4 [2.3] 5 [2.6] 6 [2.7]
Spleen (50) (48) (49) (50)
Hematopoietic Cell Proliferation 21 [2.2] 12 [2.1] 18 [2.4] 11 [2.5]
Hyperplasia, Lymphoid 17 [1.9] 18 [2.1] 15 [2.1] 15 [2.1]
Thymus (44) (45) (44) (41)
Amyloid Deposition 1 [3.0]
Angiectasis 1 [2.0]
Hyperplasia 1 [3.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Hyperplasia 3 [2.0] 4 [1.8]
Skin (50) (50) (50) (50)
Inflammation, Chronic 1 [3.0]
Inflammation, Suppurative 1 [4.0] 2 [4.0]
Epidermis, Hyperplasia 1 [3.0]
Subcutaneous Tissue, Inflammation, Chronic 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 28 [1.2] 21 [1.2] 22 [1.3] 32 [1.5]
Fracture 3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 [2.0]
Hydrocephalus 1 [2.0] 1 [2.0]
Necrosis 2 [1.0] 2 [1.0]
Meninges, Infiltration Cellular, Mononuclear
Cell 2 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Meninges, Inflammation 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Inflammation, Suppurative 3 [1.0] 2 [1.0] 3 [1.0] 1 [1.0]
Respiratory Epithelium, Epiglottis,
Metaplasia, Squamous 39 [1.0] 45 [1.0] 44 [1.1]
Squamous Epithelium, Hyperplasia 15 [1.1] 10 [1.1] 17 [1.4] 14 [1.1]
Lung (50) (50) (50) (50)
Amyloid Deposition 1 [2.0]
Hemorrhage 4 [1.3] 3 [1.0] 4 [1.8] 4 [1.3]
Infiltration Cellular, Mast Cell 1 [3.0]
Inflammation, Chronic 4 [1.0] 37 [1.3] 39 [1.8] 49 [2.0]
Inflammation, Chronic, Focal 1 [2.0]
Metaplasia, Osseous 1 [4.0]
Mineralization 1 [2.0]
Thrombosis 1 [1.0]
Alveolar Epithelium, Hyperplasia 31 [1.6] 38 [2.0] 50 [3.3]
Alveolus, Infiltration Cellular, Histiocyte 34 [2.4] 35 [2.4] 45 [2.7]
Bronchiole, Epithelium, Hyperplasia 12 [1.0] 34 [1.0] 48 [1.5]
Interstitium, Fibrosis 1 [2.0] 4 [2.5] 8 [1.5]
Perivascular, Infiltration Cellular 2 [1.5] 2 [2.5] 3 [2.7]
Nose (50) (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 [4.0]
Inflammation, Chronic 2 [3.0]
Inflammation, Suppurative 19 [1.1] 14 [1.2] 32 [1.2] 30 [1.3]
Lateral Wall, Hyperplasia 1 [2.0] 2 [1.5]
Lateral Wall, Metaplasia, Squamous 1 [1.0] 1 [2.0] 4 [1.8] 1 [1.0]
Olfactory Epithelium, Atrophy 2 [1.5] 8 [1.3] 5 [1.0] 14 [1.3]
Olfactory Epithelium, Degeneration, Hyaline 11 [1.2] 23 [1.0] 34 [1.2] 48 [1.3]
Respiratory Epithelium, Degeneration, Hyaline 35 [1.3] 39 [1.5] 46 [1.7] 50 [1.8]
Respiratory Epithelium, Hyperplasia 1 [1.0] 1 [1.0] 1 [1.0]
Respiratory Epithelium, Metaplasia, Squamous 3 [1.3] 7 [1.1] 8 [1.1]
Respiratory Epithelium, Necrosis 1 [2.0] 7 [1.4]
Pleura (1) (1)
Mesothelium, Hyperplasia 1 [4.0] 1 [2.0]
Trachea (50) (49) (47) (50)
Inflammation, Suppurative 1 [1.0]
Metaplasia, Squamous 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Anterior Chamber, Cornea, Inflammation 1 [4.0]
Harderian Gland (3) (1) (1)
Inflammation, Focal, Granulomatous 1 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Accumulation, Hyaline Droplet 2 [4.0] 1 [2.0] 1 [3.0]
Cyst 1 [2.0] 1 [1.0] 1 [1.0]
Glomerulosclerosis 1 [4.0]
Infiltration Cellular, Mononuclear Cell 1 [2.0]
Metaplasia, Osseous 3 [1.3] 3 [1.0] 1 [1.0] 2 [1.0]
Nephropathy 43 [1.1] 33 [1.1] 43 [1.0] 39 [1.0]
Pigmentation, Hemosiderin 1 [2.0]
Artery, Inflammation 1 [2.0] 1 [2.0]
Renal Tubule, Degeneration, Hyaline 1 [2.0]
Renal Tubule, Pigmentation, Hemosiderin 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 4 6 1 3
Moribund Sacrifice 7 11 13 20
Survivors
Terminal Sacrifice 39 33 36 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49)
Inflammation 2 [1.5]
Intestine Small, Jejunum (46) (48) (49) (47)
Inflammation 1 [2.0]
Intestine Small, Ileum (46) (49) (50) (48)
Inflammation, Chronic 1 [2.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [1.0]
Basophilic Focus 2
Clear Cell Focus 4 2
Clear Cell Focus, Multiple 1
Eosinophilic Focus 19 11 14 17
Eosinophilic Focus, Multiple 1 5 5 2
Hematopoietic Cell Proliferation 1 [2.0]
Infarct 1 [4.0]
Inflammation, Focal, Granulomatous 2 [1.0] 6 [1.3] 7 [1.1] 3 [1.3]
Mixed Cell Focus 1
Necrosis, Focal 8 [1.0] 3 [1.3] 5 [1.4] 4 [1.3]
Pigmentation, Hemosiderin 3 [1.7] 1 [3.0]
Tension Lipidosis 2 4 2 3
Vacuolization Cytoplasmic 1 [2.0] 1 [2.0]
Centrilobular, Degeneration 1 [2.0] 1 [1.0] 1 [2.0]
Centrilobular, Necrosis 1 [1.0]
Mesentery (9) (7) (8) (1)
Artery, Inflammation 1 [2.0]
Fat, Inflammation 3 [2.3] 3 [2.7]
Fat, Necrosis 5 [2.8] 3 [2.7] 4 [2.5] 1 [2.0]
Oral Mucosa (1)
Pharyngeal, Cyst 1 [2.0]
Pancreas (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 3 [1.0] 3 [1.0] 5 [1.0] 2 [1.0]
Salivary Glands (50) (50) (50) (50)
Inflammation 4 [1.8] 2 [1.5]
Necrosis 1 [2.0]
Stomach, Forestomach (50) (50) (50) (50)
Angiectasis 1 [2.0]
Inflammation, Suppurative 2 [1.0] 1 [2.0]
Mineralization 1 [1.0]
Ulcer 1 [1.0] 2 [1.0] 2 [1.5] 1 [1.0]
Epithelium, Hyperplasia 3 [2.3] 10 [2.0] 6 [2.5] 4 [2.3]
Stomach, Glandular (50) (49) (50) (50)
Infiltration Cellular 1 [2.0]
Inflammation, Suppurative 1 [1.0] 1 [1.0]
Mineralization 1 [1.0]
Ulcer 1 [2.0] 1 [1.0]
Epithelium, Hyperplasia 1 [1.0] 1 [2.0]
Tooth (2) (1) (2)
Inflammation 1 [2.0]
Malformation 2 1 2
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Angiectasis 1 [1.0]
Cardiomyopathy 48 [1.1] 48 [1.1] 48 [1.2] 47 [1.2]
Mineralization 1 [1.0]
Thrombosis 1 [3.0]
Artery, Inflammation 1 [2.0] 1 [2.0] 1 [2.0]
Capillary, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Degeneration, Cystic 1 [2.0]
Hyperplasia 9 [2.7] 2 [3.0]
Hypertrophy 40 [1.5] 36 [1.4] 31 [1.4] 31 [1.2]
Adrenal Medulla (50) (49) (49) (50)
Hyperplasia 2 [2.5] 1 [4.0] 1 [1.0]
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 11 [1.4] 6 [1.0] 1 [2.0] 2 [1.0]
Pituitary Gland (50) (48) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 2 [1.5] 3 [1.7] 3 [1.3]
Pars Distalis, Hyperplasia 4 [1.5] 3 [1.7] 1 [2.0]
Thyroid Gland (48) (50) (50) (50)
Follicular Cell, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 [3.0] 1 [2.0]
Inflammation 3 [1.3] 1 [2.0]
Preputial Gland (49) (50) (50) (49)
Ectasia 15 [3.2] 19 [2.6] 13 [2.4] 20 [2.8]
Inflammation 2 [1.0] 5 [2.4] 5 [2.8] 3 [2.0]
Prostate (50) (49) (49) (49)
Inflammation 4 [2.0] 1 [1.0]
Inflammation, Suppurative 1 [2.0]
Seminal Vesicle (50) (50) (50) (50)
Congestion 1 [2.0]
Inflammation, Chronic 2 [2.0]
Inflammation, Suppurative 1 [3.0] 1 [4.0]
Epithelium, Degeneration 1 [2.0]
Epithelium, Hyperplasia 1 [4.0]
Testes (50) (50) (50) (50)
Atrophy 4 [1.8] 7 [1.3] 1 [1.0] 5 [2.0]
Interstitial Cell, Hyperplasia 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 8 [2.0] 5 [2.0] 4 [2.0] 4 [2.0]
Thrombosis 1 [2.0]
Lymph Node, Bronchial (40) (38) (36) (40)
Hyperplasia 7 [2.1] 7 [2.4] 12 [2.1] 13 [2.2]
Lymph Node, Mandibular (34) (43) (27) (35)
Hyperplasia 1 [3.0] 1 [2.0] 1 [2.0]
Infiltration Cellular, Plasma Cell 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mesenteric (46) (47) (48) (44)
Hematopoietic Cell Proliferation 1 [2.0] 2 [1.5]
Hyperplasia 3 [2.0] 7 [2.0] 2 [2.0] 2 [2.0]
Lymph Node, Mediastinal (38) (36) (43) (37)
Hyperplasia 2 [2.0] 3 [1.7] 4 [2.3] 6 [2.2]
Spleen (50) (50) (50) (50)
Angiectasis 1 [2.0] 1 [1.0]
Hematopoietic Cell Proliferation 15 [1.8] 13 [2.2] 18 [2.2] 10 [2.0]
Hyperplasia, Lymphoid 9 [2.0] 12 [2.3] 15 [2.0] 10 [2.0]
Infiltration Cellular, Histiocyte 1 [2.0]
Inflammation, Focal, Granulomatous 1 [1.0]
Thymus (35) (40) (36) (35)
Epithelial Cell, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1
Inflammation, Focal, Granulomatous 1 [4.0]
Inflammation, Suppurative 1 [1.0] 1 [4.0] 1 [4.0]
Epidermis, Hyperplasia 2 [2.0]
Prepuce, Inflammation, Chronic Active 7 [2.7] 1 [3.0] 1 [1.0] 2 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 [1.0] 3 [1.0] 2 [1.0] 2 [1.0]
Fracture 1
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NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 [2.0]
Spinal Cord (1)
Hyperplasia, Lymphoid 1 [2.0]
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RESPIRATORY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
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RESPIRATORY SYSTEM - CONT
Larynx (49) (50) (49) (50)
Inflammation, Suppurative 2 [1.5] 3 [1.0]
Respiratory Epithelium, Epiglottis,
Metaplasia, Squamous 2 [1.0] 45 [1.0] 41 [1.0] 41 [1.0]
Squamous Epithelium, Hyperplasia 5 [1.0] 4 [1.3] 11 [1.0] 5 [1.2]
Lung (50) (50) (50) (50)
Hemorrhage 2 [2.0] 3 [1.3] 3 [1.0] 1 [2.0]
Inflammation, Chronic 6 [1.5] 42 [1.5] 45 [1.6] 47 [2.0]
Inflammation, Suppurative 1 [2.0]
Necrosis 1 [4.0]
Thrombosis 1 [1.0]
Alveolar Epithelium, Hyperplasia 3 [3.0] 41 [2.2] 49 [3.3] 50 [3.9]
Alveolus, Infiltration Cellular, Histiocyte 10 [2.4] 36 [2.4] 45 [2.6] 49 [3.0]
Bronchiole, Epithelium, Hyperplasia 15 [1.0] 37 [1.1] 46 [1.7]
Interstitium, Fibrosis 1 [1.0] 6 [1.7] 9 [1.2] 12 [1.7]
Mediastinum, Inflammation 1 [3.0] 1 [2.0]
Nose (50) (50) (50) (50)
Hemorrhage 1 [2.0]
Inflammation, Chronic 1 [4.0] 1 [2.0]
Inflammation, Suppurative 16 [1.3] 11 [1.4] 32 [1.2] 23 [1.3]
Lateral Wall, Hyperplasia 2 [1.0] 1 [1.0]
Lateral Wall, Metaplasia, Squamous 1 [2.0] 1 [1.0] 1 [1.0]
Olfactory Epithelium, Atrophy 6 [1.0] 7 [1.6] 9 [1.3] 12 [1.2]
Olfactory Epithelium, Degeneration, Hyaline 1 [1.0] 7 [1.0] 23 [1.1] 30 [1.2]
Respiratory Epithelium, Degeneration, Hyaline 8 [1.1] 22 [1.0] 38 [1.2] 41 [1.4]
Respiratory Epithelium, Metaplasia, Squamous 6 [1.2] 6 [1.3] 2 [1.5]
Respiratory Epithelium, Necrosis 1 [1.0] 2 [1.0]
Pleura (4) (2) (2)
Mesothelium, Hyperplasia 4 [2.3] 2 [2.0] 1 [2.0]
Trachea (49) (50) (49) (50)
Inflammation, Suppurative 1 [2.0]
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SPECIAL SENSES SYSTEM
Ear (1) (1)
Inflammation 1 [2.0]
Internal Ear, Necrosis 1 [3.0]
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URINARY SYSTEM
Kidney (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 61427-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY VANADIUM PENTOXIDE Time: 10:16:29
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.0 2.0 4.0
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Accumulation, Hyaline Droplet 1 [2.0]
Atrophy 1 [4.0]
Cyst 5 [1.4] 3 [1.3] 7 [1.4] 6 [1.5]
Hydronephrosis 2 [2.0]
Infarct, Chronic 2 [2.5]
Infiltration Cellular, Lipocyte 1 [2.0]
Metaplasia, Osseous 2 [1.0] 7 [1.0] 7 [1.0] 1 [1.0]
Mineralization 1 [3.0]
Nephropathy 48 [1.3] 50 [1.3] 48 [1.2] 48 [1.3]
Papilla, Necrosis 2 [1.5]
Renal Tubule, Hyperplasia 5 [1.0] 7 [1.0] 2 [1.0] 4 [1.0]
Renal Tubule, Necrosis 1 [1.0] 2 [1.5]
Urinary Bladder (50) (50) (50) (50)
Inflammation 1 [1.0]
Transitional Epithelium, Hyperplasia 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
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