TDMS Study 61427-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 08 TIME: 10:33:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: MILLER, RODNEY CAS: 1314-62-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#2/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 08 TIME: 10:33:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: MILLER, RODNEY CAS: 1314-62-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF VANADIUM PENTOXIDE
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex Hyperplasia
Hypertrophy
Heart Cardiomyopathy
Islets, Pancreatic Hyperplasia
Kidney Nephropathy
Larynx: Respiratory Epithelium, Epiglottis
Metaplasia
Liver Clear Cell Focus
Lung Inflammation Chronic
Lung: Alveolar Epithelium Hyperplasia
Lung: Alveolus Infiltration Cellular Histiocyte
Lung: Bronchiole, Epithelium Hyperplasia
Lung: Interstitium Fibrosis
Lymph Node, Bronchial Hyperplasia
Lymph Node, Mediastinal Hyperplasia
Nose Inflammation
Nose: Olfactory Epithelium Atrophy
Degeneration Hyaline
Nose: Respiratory Epithelium Degeneration Hyaline
Metaplasia
Necrosis
Preputial Gland Ectasia
Prostate Inflammation
Skin: Prepuce Inflammation Chronic
Stomach, Forestomach: Epithelium Hyperplasia
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Adrenal Medulla Hyperplasia
Bone Fibrous Osteodystrophy
Kidney Nephropathy
Larynx: Respiratory Epithelium, Epiglottis
Metaplasia
Liver Eosinophilic Focus
Inflammation Focal Granulomatous
Necrosis Focal
Lung Inflammation Chronic
Lung: Alveolar Epithelium Hyperplasia
Lung: Alveolus Infiltration Cellular Histiocyte
Lung: Bronchiole, Epithelium Hyperplasia
Lung: Interstitium Fibrosis
Lymph Node Angiectasis
Lymph Node, Bronchial Hyperplasia
Nose Inflammation
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest VANADIUM PENTOXIDE DATE: 11/19/01
EXPERIMENT: 61427 TEST: 08 TIME: 10:33:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61427B
PATHOLOGIST: MILLER, RODNEY CAS: 1314-62-1
Nose: Olfactory Epithelium Atrophy
Degeneration Hyaline
Nose: Respiratory Epithelium Degeneration Hyaline
Metaplasia
Necrosis
Spleen Hematopoietic Cell Proliferation
Stomach, Forestomach Cyst
Thyroid Gland Inflammation
Uterus Angiectasis
===============================================================
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/49 (2%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 2/49 (4%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/46.78 1/43.43 0/45.85 0/40.35 |0/45.55 0/41.52 2/40.00 2/42.50 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 0.0% 0.0% |0.0% 0.0% 5.0% 4.7% |
|TERMINAL (d) | 0/39 (0%) 1/33 (3%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 1/30 (3%) 1/31 (3%) |
|FIRST INCIDENCE | --- 729 (T) --- --- |--- --- 705 726 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.617N P=0.467 (e) (e) |P=0.076 (e) P=0.197 P=0.206 |
|POLY 3 | P=0.576N P=0.485 (e) (e) |P=0.080 (e) P=0.209 P=0.222 |
|POLY 1.5 | P=0.573N P=0.489 (e) (e) |P=0.084 (e) P=0.218 P=0.229 |
|POLY 6 | P=0.579N P=0.480 (e) (e) |P=0.076 (e) P=0.202 P=0.215 |
|LOGISTIC REGRESSION| (e) P=0.467 (e) (e) |P=0.078 (e) P=0.204 P=0.208 |
|COCH-ARM / FISHERS | P=0.566N P=0.495 (e) (e) |P=0.083 (e) P=0.242 P=0.242 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 0/49 (0%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/49 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 9/46.78 0/43.43 2/45.90 0/40.35 |0/45.55 0/41.52 0/39.90 0/42.48 |
|POLY-3 PERCENT (g) | 19.2% 0.0% 4.4% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 9/39 (23%) 0/33 (0%) 1/36 (3%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE | 729 (T) --- 718 --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.003N** P=0.005N** P=0.037N* P=0.011N* |(e) (e) (e) (e) |
|POLY 3 | P<0.001N** P=0.002N** P=0.027N* P=0.004N** |(e) (e) (e) (e) |
|POLY 1.5 | P<0.001N** P=0.002N** P=0.026N* P=0.003N** |(e) (e) (e) (e) |
|POLY 6 | P<0.001N** P=0.003N** P=0.028N* P=0.006N** |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.003N** (e) P=0.034N* (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001N** P<0.001N** P=0.026N* P<0.001N** |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 40/50 (80%) 36/49 (73%) 31/50 (62%) 31/50 (62%) |5/50 (10%) 5/50 (10%) 3/49 (6%) 7/49 (14%) |
|POLY-3 RATE (b) | 40/47.73 36/46.09 31/47.94 31/45.10 |5/45.73 5/41.95 3/40.16 7/43.39 |
|POLY-3 PERCENT (g) | 83.8% 78.1% 64.7% 68.7% |10.9% 11.9% 7.5% 16.1% |
|TERMINAL (d) | 34/39 (87%) 29/33 (88%) 25/36 (69%) 19/27 (70%) |4/38 (11%) 4/32 (13%) 2/30 (7%) 5/31 (16%) |
|FIRST INCIDENCE | 620 514 422 387 |686 603 662 550 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.450 P=0.423 P=0.140N P=0.360 |P=0.233 P=0.522 P=0.485N P=0.271 |
|POLY 3 | P=0.035N* P=0.321N P=0.022N* P=0.058N |P=0.289 P=0.575 P=0.430N P=0.342 |
|POLY 1.5 | P=0.028N* P=0.312N P=0.027N* P=0.046N* |P=0.302 P=0.591 P=0.405N P=0.358 |
|POLY 6 | P=0.049N* P=0.336N P=0.020N* P=0.087N |P=0.276 P=0.556 P=0.450N P=0.325 |
|LOGISTIC REGRESSION| P=0.088N P=0.486N P=0.045N* P=0.157N |P=0.292 P=0.576 P=0.435N P=0.353 |
|COCH-ARM / FISHERS | P=0.024N* P=0.298N P=0.038N* P=0.038N* |P=0.302 P=0.630N P=0.369N P=0.365 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/49 (4%) 1/49 (2%) 1/50 (2%) |4/49 (8%) 0/50 (0%) 0/48 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/46.78 2/44.04 1/44.85 1/40.35 |4/45.58 0/41.52 0/39.39 0/42.48 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 2.2% 2.5% |8.8% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 1/33 (3%) 1/35 (3%) 1/27 (4%) |2/38 (5%) 0/32 (0%) 0/30 (0%) 0/31 (0%) |
|FIRST INCIDENCE | --- 530 729 (T) 729 (T) |683 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.426 P=0.221 P=0.478 P=0.427 |P=0.028N* P=0.092N P=0.097N P=0.086N |
|POLY 3 | P=0.434 P=0.224 P=0.492 P=0.471 |P=0.017N* P=0.073N P=0.081N P=0.070N |
|POLY 1.5 | P=0.462 P=0.227 P=0.493 P=0.483 |P=0.017N* P=0.068N P=0.074N P=0.064N |
|POLY 6 | P=0.398 P=0.220 P=0.489 P=0.455 |P=0.016N* P=0.080N P=0.088N P=0.076N |
|LOGISTIC REGRESSION| P=0.533 P=0.298 P=0.478 P=0.427 |P=0.023N* P=0.068N P=0.074N P=0.065N |
|COCH-ARM / FISHERS | P=0.501 P=0.242 P=0.495 P=0.500 |P=0.021N* P=0.056N P=0.061N P=0.059N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Bone |
| Fibrous Osteodystrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 2/50 (4%) 2/50 (4%) |28/50 (56%) 21/50 (42%) 22/50 (44%) 32/50 (64%) |
|POLY-3 RATE (b) | 1/46.78 3/44.23 2/45.85 2/40.35 |28/46.13 21/42.32 22/41.17 32/45.20 |
|POLY-3 PERCENT (g) | 2.1% 6.8% 4.4% 5.0% |60.7% 49.6% 53.4% 70.8% |
|TERMINAL (d) | 1/39 (3%) 2/33 (6%) 2/36 (6%) 2/27 (7%) |25/38 (66%) 19/32 (59%) 16/30 (53%) 25/32 (78%) |
|FIRST INCIDENCE | 729 (T) 695 729 (T) 729 (T) |626 564 584 550 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.362 P=0.253 P=0.472 P=0.372 |P=0.031 * P=0.342N P=0.550N P=0.059 |
|POLY 3 | P=0.425 P=0.286 P=0.493 P=0.449 |P=0.102 P=0.198N P=0.317N P=0.206 |
|POLY 1.5 | P=0.456 P=0.293 P=0.496 P=0.470 |P=0.125 P=0.169N P=0.249N P=0.251 |
|POLY 6 | P=0.386 P=0.276 P=0.489 P=0.421 |P=0.082 P=0.241N P=0.363N P=0.160 |
|LOGISTIC REGRESSION| P=0.374 P=0.272 P=0.472 P=0.372 |P=0.063 P=0.282N P=0.423N P=0.129 |
|COCH-ARM / FISHERS | P=0.500 P=0.309 P=0.500 P=0.500 |P=0.131 P=0.115N P=0.159N P=0.270 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Bone |
| Fracture |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 1/46.66 0/40.35 |0/45.55 0/41.52 3/42.44 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.1% 0.0% |0.0% 0.0% 7.1% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- 422 --- |--- --- 251 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.690 (e) P=0.500 (e) |P=0.548 (e) P=0.119 (e) |
|POLY 3 | P=0.631 (e) P=0.499 (e) |P=0.529 (e) P=0.106 (e) |
|POLY 1.5 | P=0.658 (e) P=0.500 (e) |P=0.542 (e) P=0.112 (e) |
|POLY 6 | P=0.592 (e) P=0.498 (e) |P=0.514 (e) P=0.102 (e) |
|LOGISTIC REGRESSION| P=0.546N (e) (e) (e) |P=0.380 (e) P=0.103 (e) |
|COCH-ARM / FISHERS | P=0.694 (e) P=0.500 (e) |P=0.539 (e) P=0.121 (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 5/50 (10%) 4/50 (8%) 4/50 (8%) |5/50 (10%) 1/50 (2%) 6/50 (12%) 6/50 (12%) |
|POLY-3 RATE (b) | 8/47.53 5/45.98 4/46.18 4/41.19 |5/45.74 1/41.78 6/41.62 6/44.25 |
|POLY-3 PERCENT (g) | 16.8% 10.9% 8.7% 9.7% |10.9% 2.4% 14.4% 13.6% |
|TERMINAL (d) | 6/39 (15%) 2/33 (6%) 2/36 (6%) 3/27 (11%) |4/38 (11%) 0/32 (0%) 3/30 (10%) 4/32 (13%) |
|FIRST INCIDENCE | 499 405 653 394 |681 660 318 542 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.274N P=0.361N P=0.220N P=0.366N |P=0.184 P=0.153N P=0.363 P=0.406 |
|POLY 3 | P=0.193N P=0.298N P=0.191N P=0.254N |P=0.227 P=0.123N P=0.434 P=0.477 |
|POLY 1.5 | P=0.173N P=0.289N P=0.186N P=0.219N |P=0.235 P=0.117N P=0.459 P=0.493 |
|POLY 6 | P=0.219N P=0.310N P=0.197N P=0.304N |P=0.219 P=0.132N P=0.416 P=0.458 |
|LOGISTIC REGRESSION| P=0.075N P=0.159N P=0.172N P=0.138N |P=0.227 P=0.120N P=0.505 P=0.489 |
|COCH-ARM / FISHERS | P=0.146N P=0.277N P=0.178N P=0.178N |P=0.226 P=0.102N P=0.500 P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Brain |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 0/43.10 0/45.85 0/40.35 |2/46.22 0/41.52 2/41.48 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |4.3% 0.0% 4.8% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/32 (0%) 0/36 (0%) 0/27 (0%) |1/38 (3%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |505 --- 318 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.258N P=0.263N P=0.646 P=0.259N |
|POLY 3 | (e) (e) (e) (e) |P=0.246N P=0.262N P=0.654 P=0.251N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.242N P=0.254N P=0.670 P=0.243N |
|POLY 6 | (e) (e) (e) (e) |P=0.250N P=0.271N P=0.642 P=0.260N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.278N P=0.218N P=0.653N P=0.248N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.247N P=0.247N P=0.691N P=0.247N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Brain: Meninges |
| Infiltration Cellular Mononuclear Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/49 (2%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 1/43.10 0/45.85 0/40.35 |0/45.55 2/41.52 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 0.0% 0.0% |0.0% 4.8% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 1/32 (3%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 2/32 (6%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- 729 (T) --- --- |--- 731 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.615N P=0.461 (e) (e) |P=0.437N P=0.201 (e) (e) |
|POLY 3 | P=0.577N P=0.484 (e) (e) |P=0.434N P=0.217 (e) (e) |
|POLY 1.5 | P=0.573N P=0.489 (e) (e) |P=0.422N P=0.223 (e) (e) |
|POLY 6 | P=0.580N P=0.478 (e) (e) |P=0.447N P=0.210 (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.461 (e) (e) |(e) P=0.201 (e) (e) |
|COCH-ARM / FISHERS | P=0.566N P=0.495 (e) (e) |P=0.405N P=0.247 (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | |
|POLY-3 RATE (b) | 3/46.78 0/44.10 1/45.85 0/40.35 | |
|POLY-3 PERCENT (g) | 6.4% 0.0% 2.2% 0.0% | |
|TERMINAL (d) | 3/39 (8%) 0/33 (0%) 1/36 (3%) 0/27 (0%) | |
|FIRST INCIDENCE | 729 (T) --- 729 (T) --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.119N P=0.152N P=0.334N P=0.193N | |
|POLY 3 | P=0.087N P=0.130N P=0.313N P=0.148N | |
|POLY 1.5 | P=0.086N P=0.125N P=0.310N P=0.135N | |
|POLY 6 | P=0.089N P=0.135N P=0.317N P=0.165N | |
|LOGISTIC REGRESSION| P=0.119N (e) P=0.334N (e) | |
|COCH-ARM / FISHERS | P=0.086N P=0.121N P=0.309N P=0.121N | |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Esophagus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 2/47.55 0/44.10 0/45.85 0/40.20 |0/45.55 0/41.52 0/39.96 0/43.06 |
|POLY-3 PERCENT (g) | 4.2% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 523 --- --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.130N P=0.258N P=0.245N P=0.290N |(e) (e) (e) (e) |
|POLY 3 | P=0.105N P=0.254N P=0.245N P=0.276N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.109N P=0.247N P=0.242N P=0.261N |(e) (e) (e) (e) |
|POLY 6 | P=0.100N P=0.263N P=0.250N P=0.298N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.074N P=0.135N P=0.175N P=0.110N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.116N P=0.247N P=0.247N P=0.253N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 48/50 (96%) 48/50 (96%) 47/50 (94%) |47/50 (94%) 45/50 (90%) 46/50 (92%) 49/50 (98%) |
|POLY-3 RATE (b) | 48/48.69 48/49.23 48/49.16 47/48.88 |47/47.35 45/45.94 46/46.87 49/49.04 |
|POLY-3 PERCENT (g) | 98.6% 97.5% 97.6% 96.2% |99.3% 98.0% 98.1% 99.9% |
|TERMINAL (d) | 39/39 (100%) 33/33 (100%) 36/36 (100%) 26/27 (96%) |38/38 (100%) 32/32 (100%) 30/30 (100%) 32/32 (100%) |
|FIRST INCIDENCE | 603 405 422 387 |626 446 270 478 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.008 ** P=0.106 P=0.299 P=0.008 ** |P=0.058 P=0.164 P=0.055 P=0.056 |
|POLY 3 | P=0.297N P=0.680N P=0.710N P=0.443N |P=0.488 P=0.693N P=0.727N P=0.980 |
|POLY 1.5 | P=0.338N P=0.671N P=0.685N P=0.464N |P=0.410 P=0.600N P=0.550N P=0.783 |
|POLY 6 | P=0.246N P=0.803N P=0.864N P=0.445N |P=0.740 P=0.959N P=0.895N P=1.000 |
|LOGISTIC REGRESSION| P=0.482 P=0.462 P=0.657 P=0.520 |P=0.163 P=0.685 P=0.488 P=0.257 |
|COCH-ARM / FISHERS | P=0.387N P=0.691N P=0.691N P=0.500N |P=0.178 P=0.357N P=0.500N P=0.309 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Heart |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 1/44.43 0/45.85 0/40.35 |2/47.21 1/42.52 1/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 0.0% 0.0% |4.2% 2.4% 2.5% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 1/30 (3%) 0/32 (0%) |
|FIRST INCIDENCE | --- 639 --- --- |181 23 731 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.590N P=0.486 (e) (e) |P=0.162N P=0.507N P=0.540N P=0.238N |
|POLY 3 | P=0.577N P=0.490 (e) (e) |P=0.163N P=0.536N P=0.558N P=0.256N |
|POLY 1.5 | P=0.574N P=0.494 (e) (e) |P=0.158N P=0.525N P=0.538N P=0.247N |
|POLY 6 | P=0.580N P=0.485 (e) (e) |P=0.168N P=0.550N P=0.573N P=0.265N |
|LOGISTIC REGRESSION| P=0.511N P=0.559 (e) (e) |P=0.215N P=0.291N P=0.460N P=0.369N |
|COCH-ARM / FISHERS | P=0.567N P=0.500 (e) (e) |P=0.153N P=0.500N P=0.500N P=0.247N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Heart: Capillary |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/46.78 0/44.10 0/45.85 0/40.35 |2/45.55 0/41.52 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 2.1% 0.0% 0.0% 0.0% |4.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/39 (3%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |2/38 (5%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |731 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.342N P=0.533N P=0.516N P=0.573N |P=0.135N P=0.277N P=0.292N P=0.277N |
|POLY 3 | P=0.284N P=0.512N P=0.504N P=0.529N |P=0.109N P=0.258N P=0.268N P=0.248N |
|POLY 1.5 | P=0.294N P=0.507N P=0.502N P=0.517N |P=0.110N P=0.252N P=0.256N P=0.241N |
|POLY 6 | P=0.272N P=0.517N P=0.506N P=0.545N |P=0.108N P=0.266N P=0.277N P=0.255N |
|LOGISTIC REGRESSION| P=0.342N (e) (e) (e) |P=0.135N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.306N P=0.500N P=0.500N P=0.500N |P=0.115N P=0.247N P=0.247N P=0.247N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 6/50 (12%) 1/50 (2%) 2/50 (4%) |0/50 (0%) 1/50 (2%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 11/47.03 6/45.73 1/45.85 2/40.69 |0/45.55 1/41.54 0/39.90 0/43.48 |
|POLY-3 PERCENT (g) | 23.4% 13.1% 2.2% 4.9% |0.0% 2.4% 0.0% 0.0% |
|TERMINAL (d) | 9/39 (23%) 3/33 (9%) 1/36 (3%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 667 530 729 (T) 676 |--- 726 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.008N** P=0.235N P=0.005N** P=0.047N* |P=0.580N P=0.472 (e) (e) |
|POLY 3 | P=0.002N** P=0.156N P=0.002N** P=0.015N* |P=0.586N P=0.482 (e) (e) |
|POLY 1.5 | P=0.002N** P=0.151N P=0.002N** P=0.011N* |P=0.579N P=0.487 (e) (e) |
|POLY 6 | P=0.003N** P=0.163N P=0.002N** P=0.022N* |P=0.594N P=0.475 (e) (e) |
|LOGISTIC REGRESSION| P=0.002N** P=0.127N P=0.003N** P=0.023N* |P=0.577N P=0.470 (e) (e) |
|COCH-ARM / FISHERS | P=0.002N** P=0.143N P=0.002N** P=0.007N** |P=0.567N P=0.500 (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney |
| Accumulation, Hyaline Droplet |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |2/50 (4%) 1/50 (2%) 0/49 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 0/45.85 1/40.83 |2/45.76 1/42.13 0/39.90 1/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 2.5% |4.4% 2.4% 0.0% 2.3% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- --- --- 586 |695 530 --- 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.180 (e) (e) P=0.469 |P=0.389N P=0.539N P=0.283N P=0.541N |
|POLY 3 | P=0.184 (e) (e) P=0.473 |P=0.373N P=0.529N P=0.269N P=0.518N |
|POLY 1.5 | P=0.190 (e) (e) P=0.484 |P=0.369N P=0.521N P=0.258N P=0.507N |
|POLY 6 | P=0.177 (e) (e) P=0.459 |P=0.378N P=0.540N P=0.279N P=0.531N |
|LOGISTIC REGRESSION| P=0.282 (e) (e) P=0.656 |P=0.368N P=0.486N P=0.256N P=0.514N |
|COCH-ARM / FISHERS | P=0.198 (e) (e) P=0.500 |P=0.367N P=0.500N P=0.253N P=0.500N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 7/50 (14%) 6/50 (12%) |1/50 (2%) 1/50 (2%) 0/49 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 5/46.78 3/44.10 7/45.85 6/41.08 |1/45.55 1/41.52 0/39.90 1/43.48 |
|POLY-3 PERCENT (g) | 10.7% 6.8% 15.3% 14.6% |2.2% 2.4% 0.0% 2.3% |
|TERMINAL (d) | 5/39 (13%) 3/33 (9%) 7/36 (19%) 3/27 (11%) |1/38 (3%) 1/32 (3%) 0/30 (0%) 1/32 (3%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 654 |731 (T) 731 (T) --- 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.138 P=0.450N P=0.322 P=0.278 |P=0.651 P=0.723 P=0.547N P=0.723 |
|POLY 3 | P=0.234 P=0.389N P=0.365 P=0.410 |P=0.624N P=0.740 P=0.526N P=0.750 |
|POLY 1.5 | P=0.262 P=0.376N P=0.371 P=0.446 |P=0.619N P=0.746 P=0.518N P=0.757 |
|POLY 6 | P=0.203 P=0.405N P=0.356 P=0.367 |P=0.628N P=0.732 P=0.534N P=0.743 |
|LOGISTIC REGRESSION| P=0.170 P=0.450N P=0.322 P=0.371 |P=0.651 P=0.723 (e) P=0.723 |
|COCH-ARM / FISHERS | P=0.306 P=0.357N P=0.380 P=0.500 |P=0.616N P=0.753N P=0.505N P=0.753N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney |
| Hydronephrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 2/44.58 0/45.85 0/40.35 |0/45.55 0/41.52 0/39.90 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- 590 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.456N P=0.218 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.433N P=0.227 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.422N P=0.231 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.447N P=0.222 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.354N P=0.274 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.405N P=0.247 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney |
| Infarct Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 2/45.85 0/40.35 |0/45.55 0/41.52 0/39.90 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.4% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 2/36 (6%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- 729 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.531 (e) P=0.221 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.516 (e) P=0.233 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.550 (e) P=0.235 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.470 (e) P=0.230 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.221 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.595 (e) P=0.247 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney |
| Metaplasia Osseous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 7/50 (14%) 1/50 (2%) |3/50 (6%) 3/50 (6%) 1/49 (2%) 2/50 (4%) |
|POLY-3 RATE (b) | 2/46.78 7/44.57 7/45.85 1/40.35 |3/45.55 3/41.78 1/39.90 2/43.65 |
|POLY-3 PERCENT (g) | 4.3% 15.7% 15.3% 2.5% |6.6% 7.2% 2.5% 4.6% |
|TERMINAL (d) | 2/39 (5%) 6/33 (18%) 7/36 (19%) 1/27 (4%) |3/38 (8%) 2/32 (6%) 1/30 (3%) 1/32 (3%) |
|FIRST INCIDENCE | 729 (T) 590 729 (T) 729 (T) |731 (T) 660 731 (T) 687 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.436N P=0.050 P=0.062 P=0.628N |P=0.403N P=0.581 P=0.393N P=0.567N |
|POLY 3 | P=0.376N P=0.068 P=0.074 P=0.551N |P=0.359N P=0.622 P=0.354N P=0.519N |
|POLY 1.5 | P=0.324N P=0.072 P=0.076 P=0.530N |P=0.349N P=0.633 P=0.338N P=0.507N |
|POLY 6 | P=0.446N P=0.062 P=0.071 P=0.578N |P=0.370N P=0.608 P=0.368N P=0.533N |
|LOGISTIC REGRESSION| P=0.391N P=0.067 P=0.062 P=0.628N |P=0.367N P=0.611 P=0.393N P=0.537N |
|COCH-ARM / FISHERS | P=0.260N P=0.080 P=0.080 P=0.500N |P=0.345N P=0.661N P=0.316N P=0.500N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 50/50 (100%) 48/50 (96%) 48/50 (96%) |43/50 (86%) 33/50 (66%) 43/49 (88%) 39/50 (78%) |
|POLY-3 RATE (b) | 48/48.98 50/50.00 48/49.59 48/48.57 |43/47.63 33/43.47 43/45.16 39/48.55 |
|POLY-3 PERCENT (g) | 98.0% 100.0% 96.8% 98.8% |90.3% 75.9% 95.2% 80.3% |
|TERMINAL (d) | 39/39 (100%) 33/33 (100%) 35/36 (97%) 27/27 (100%)|35/38 (92%) 27/32 (84%) 30/30 (100%) 25/32 (78%) |
|FIRST INCIDENCE | 499 405 422 394 |505 522 270 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.008 ** P=0.055 P=0.312 P=0.004 ** |P=0.224 P=0.278N P=0.044 * P=0.430 |
|POLY 3 | P=0.679 P=0.503 P=0.618N P=0.755 |P=0.234N P=0.047N* P=0.291 P=0.131N |
|POLY 1.5 | P=0.595N P=0.343 P=0.655N P=0.698 |P=0.257N P=0.031N* P=0.408 P=0.125N |
|POLY 6 | P=0.704 P=0.881 P=0.564N P=0.938 |P=0.202N P=0.090N P=0.213 P=0.142N |
|LOGISTIC REGRESSION| P=0.470 P=0.098 P=0.641 P=0.215 |P=0.461N P=0.054N P=0.242 P=0.208N |
|COCH-ARM / FISHERS | P=0.444N P=0.247 P=0.691N P=0.691N |P=0.486N P=0.017N* P=0.516 P=0.218N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney: Papilla |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/46.78 0/44.10 0/45.85 0/40.35 |0/45.55 0/41.52 0/39.90 0/43.48 |
|POLY-3 PERCENT (g) | 4.3% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/39 (5%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.141N P=0.276N P=0.256N P=0.322N |(e) (e) (e) (e) |
|POLY 3 | P=0.104N P=0.251N P=0.242N P=0.272N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.108N P=0.245N P=0.240N P=0.257N |(e) (e) (e) (e) |
|POLY 6 | P=0.099N P=0.257N P=0.244N P=0.292N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.141N (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 7/50 (14%) 2/50 (4%) 4/50 (8%) |0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 5/46.78 7/44.10 2/45.90 4/40.96 |0/45.55 0/41.52 0/39.90 0/43.48 |
|POLY-3 PERCENT (g) | 10.7% 15.9% 4.4% 9.8% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 5/39 (13%) 7/33 (21%) 1/36 (3%) 2/27 (7%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 718 573 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.466N P=0.264 P=0.250N P=0.566 |(e) (e) (e) (e) |
|POLY 3 | P=0.334N P=0.338 P=0.224N P=0.583N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.312N P=0.355 P=0.221N P=0.549N |(e) (e) (e) (e) |
|POLY 6 | P=0.362N P=0.318 P=0.228N P=0.625N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.402N P=0.264 P=0.241N P=0.604N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.279N P=0.380 P=0.218N P=0.500N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/47.16 2/44.98 0/45.85 0/40.35 |0/45.55 0/41.52 0/39.90 0/43.48 |
|POLY-3 PERCENT (g) | 2.1% 4.5% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 620 558 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.211N P=0.477 P=0.509N P=0.542N |(e) (e) (e) (e) |
|POLY 3 | P=0.205N P=0.483 P=0.506N P=0.531N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.198N P=0.490 P=0.503N P=0.518N |(e) (e) (e) (e) |
|POLY 6 | P=0.214N P=0.476 P=0.509N P=0.548N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.098N P=0.659 P=0.455N P=0.397N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.188N P=0.500 P=0.500N P=0.500N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Larynx |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 3/49 (6%) 0/50 (0%) |3/50 (6%) 2/50 (4%) 3/49 (6%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/46.31 0/44.10 3/45.59 0/40.35 |3/46.54 2/42.01 3/39.63 1/43.62 |
|POLY-3 PERCENT (g) | 4.3% 0.0% 6.6% 0.0% |6.5% 4.8% 7.6% 2.3% |
|TERMINAL (d) | 1/39 (3%) 0/33 (0%) 2/36 (6%) 0/27 (0%) |2/38 (5%) 0/32 (0%) 3/30 (10%) 0/32 (0%) |
|FIRST INCIDENCE | 692 --- 639 --- |181 603 731 (T) 695 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.381N P=0.275N P=0.474 P=0.329N |P=0.308N P=0.554N P=0.571 P=0.344N |
|POLY 3 | P=0.337N P=0.248N P=0.493 P=0.269N |P=0.281N P=0.546N P=0.586 P=0.329N |
|POLY 1.5 | P=0.317N P=0.242N P=0.496 P=0.254N |P=0.271N P=0.535N P=0.608 P=0.318N |
|POLY 6 | P=0.364N P=0.257N P=0.489 P=0.291N |P=0.292N P=0.559N P=0.570 P=0.340N |
|LOGISTIC REGRESSION| P=0.310N P=0.241N P=0.505 P=0.268N |P=0.267N P=0.449N P=0.649N P=0.337N |
|COCH-ARM / FISHERS | P=0.292N P=0.242N P=0.500 P=0.242N |P=0.264N P=0.500N P=0.651 P=0.309N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Larynx: Respiratory Epithelium, Epiglottis |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 45/50 (90%) 41/49 (84%) 41/50 (82%) |0/50 (0%) 39/50 (78%) 45/49 (92%) 44/50 (88%) |
|POLY-3 RATE (b) | 2/46.16 45/49.91 41/47.00 41/47.66 |0/45.55 39/47.47 45/48.49 44/49.71 |
|POLY-3 PERCENT (g) | 4.3% 90.2% 87.2% 86.0% |0.0% 82.2% 92.8% 88.5% |
|TERMINAL (d) | 2/39 (5%) 30/33 (91%) 34/36 (94%) 22/27 (82%) |0/38 (0%) 25/32 (78%) 27/30 (90%) 27/32 (84%) |
|FIRST INCIDENCE | 729 (T) 405 606 387 |--- 23 251 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Larynx: Squamous Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 4/50 (8%) 11/49 (22%) 5/50 (10%) |15/50 (30%) 10/50 (20%) 17/49 (35%) 14/50 (28%) |
|POLY-3 RATE (b) | 5/46.16 4/44.81 11/45.59 5/40.35 |15/47.49 10/43.56 17/43.97 14/46.13 |
|POLY-3 PERCENT (g) | 10.8% 8.9% 24.1% 12.4% |31.6% 23.0% 38.7% 30.4% |
|TERMINAL (d) | 5/39 (13%) 2/33 (6%) 10/36 (28%) 5/27 (19%) |11/38 (29%) 4/32 (13%) 8/30 (27%) 8/32 (25%) |
|FIRST INCIDENCE | 729 (T) 514 639 729 (T) |181 23 251 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.210 P=0.585N P=0.061 P=0.388 |P=0.344 P=0.323N P=0.215 P=0.509 |
|POLY 3 | P=0.298 P=0.519N P=0.079 P=0.544 |P=0.452 P=0.246N P=0.313 P=0.537N |
|POLY 1.5 | P=0.354 P=0.506N P=0.081 P=0.586 |P=0.469 P=0.225N P=0.333 P=0.513N |
|POLY 6 | P=0.231 P=0.535N P=0.075 P=0.487 |P=0.434 P=0.268N P=0.313 P=0.563N |
|LOGISTIC REGRESSION| P=0.289 P=0.492N P=0.072 P=0.388 |P=0.445 P=0.158N P=0.432 P=0.495N |
|COCH-ARM / FISHERS | P=0.439 P=0.487N P=0.085 P=0.617N |P=0.455 P=0.178N P=0.388 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/46.85 0/44.10 0/45.85 0/40.35 |0/45.55 0/41.52 0/39.96 1/43.48 |
|POLY-3 PERCENT (g) | 4.3% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 2.3% |
|TERMINAL (d) | 1/39 (3%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 1/32 (3%) |
|FIRST INCIDENCE | 710 --- --- --- |--- --- --- 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.143N P=0.270N P=0.257N P=0.329N |P=0.187 (e) (e) P=0.466 |
|POLY 3 | P=0.104N P=0.251N P=0.242N P=0.272N |P=0.197 (e) (e) P=0.491 |
|POLY 1.5 | P=0.108N P=0.245N P=0.240N P=0.257N |P=0.200 (e) (e) P=0.497 |
|POLY 6 | P=0.099N P=0.258N P=0.245N P=0.292N |P=0.194 (e) (e) P=0.484 |
|LOGISTIC REGRESSION| P=0.130N P=0.256N P=0.243N P=0.295N |(e) (e) (e) P=0.466 |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |P=0.198 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/50 (0%) 0/50 (0%) |1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/46.78 3/44.10 0/45.85 0/40.35 |1/45.55 0/41.52 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 8.6% 6.8% 0.0% 0.0% |2.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/39 (10%) 3/33 (9%) 0/36 (0%) 0/27 (0%) |1/38 (3%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- --- |731 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.028N* P=0.591N P=0.073N P=0.118N |P=0.328N P=0.534N P=0.547N P=0.534N |
|POLY 3 | P=0.017N* P=0.532N P=0.063N P=0.082N |P=0.301N P=0.518N P=0.526N P=0.509N |
|POLY 1.5 | P=0.017N* P=0.519N P=0.062N P=0.072N |P=0.303N P=0.513N P=0.517N P=0.503N |
|POLY 6 | P=0.019N* P=0.548N P=0.064N P=0.095N |P=0.298N P=0.525N P=0.534N P=0.516N |
|LOGISTIC REGRESSION| P=0.028N* P=0.591N (e) (e) |P=0.328N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.016N* P=0.500N P=0.059N P=0.059N |P=0.306N P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 16/50 (32%) 19/50 (38%) 19/50 (38%) |16/50 (32%) 14/50 (28%) 4/50 (8%) 8/50 (16%) |
|POLY-3 RATE (b) | 20/47.84 16/44.71 19/47.21 19/44.03 |16/46.59 14/42.91 4/41.83 8/43.92 |
|POLY-3 PERCENT (g) | 41.8% 35.8% 40.2% 43.2% |34.3% 32.6% 9.6% 18.2% |
|TERMINAL (d) | 18/39 (46%) 15/33 (46%) 15/36 (42%) 9/27 (33%) |13/38 (34%) 11/32 (34%) 1/30 (3%) 6/32 (19%) |
|FIRST INCIDENCE | 499 534 534 494 |505 522 318 611 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.142 P=0.484N P=0.548 P=0.217 |P=0.039N* P=0.549 P=0.015N* P=0.117N |
|POLY 3 | P=0.422 P=0.351N P=0.521N P=0.532 |P=0.016N* P=0.521N P=0.005N** P=0.065N |
|POLY 1.5 | P=0.458 P=0.316N P=0.514N P=0.581 |P=0.014N* P=0.491N P=0.003N** P=0.054N |
|POLY 6 | P=0.387 P=0.398N P=0.529N P=0.480 |P=0.020N* P=0.558N P=0.006N** P=0.078N |
|LOGISTIC REGRESSION| P=0.421 P=0.341N P=0.510N P=0.539N |P=0.016N* P=0.491N P=0.003N** P=0.059N |
|COCH-ARM / FISHERS | P=0.520 P=0.266N P=0.500N P=0.500N |P=0.015N* P=0.414N P=0.003N** P=0.050N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |4/50 (8%) 0/50 (0%) 6/50 (12%) 3/50 (6%) |
|POLY-3 RATE (b) | 0/46.78 1/44.10 0/45.85 0/40.35 |4/46.14 0/41.52 6/42.73 3/44.16 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 0.0% 0.0% |8.7% 0.0% 14.0% 6.8% |
|TERMINAL (d) | 0/39 (0%) 1/33 (3%) 0/36 (0%) 0/27 (0%) |1/38 (3%) 0/32 (0%) 1/30 (3%) 1/32 (3%) |
|FIRST INCIDENCE | --- 729 (T) --- --- |662 --- 270 550 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.617N P=0.467 (e) (e) |P=0.444 P=0.095N P=0.282 P=0.557N |
|POLY 3 | P=0.578N P=0.488 (e) (e) |P=0.486 P=0.075N P=0.322 P=0.524N |
|POLY 1.5 | P=0.574N P=0.493 (e) (e) |P=0.496 P=0.070N P=0.341 P=0.508N |
|POLY 6 | P=0.581N P=0.483 (e) (e) |P=0.475 P=0.082N P=0.308 P=0.543N |
|LOGISTIC REGRESSION| (e) P=0.467 (e) (e) |P=0.460 P=0.066N P=0.430 P=0.500N |
|COCH-ARM / FISHERS | P=0.567N P=0.500 (e) (e) |P=0.481 P=0.059N P=0.370 P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Focal Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 7/50 (14%) 3/50 (6%) |12/50 (24%) 26/50 (52%) 19/50 (38%) 21/50 (42%) |
|POLY-3 RATE (b) | 2/47.46 6/44.16 7/45.85 3/40.83 |12/45.64 26/41.88 19/40.59 21/44.19 |
|POLY-3 PERCENT (g) | 4.2% 13.6% 15.3% 7.4% |26.3% 62.1% 46.8% 47.5% |
|TERMINAL (d) | 1/39 (3%) 5/33 (15%) 7/36 (19%) 2/27 (7%) |11/38 (29%) 24/32 (75%) 17/30 (57%) 17/32 (53%) |
|FIRST INCIDENCE | 499 714 729 (T) 586 |709 635 584 612 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.340 P=0.098 P=0.066 P=0.383 |P=0.044 * P<0.001 ** P=0.015 * P=0.012 * |
|POLY 3 | P=0.400 P=0.111 P=0.071 P=0.432 |P=0.099 P<0.001 ** P=0.036 * P=0.028 * |
|POLY 1.5 | P=0.454 P=0.120 P=0.074 P=0.460 |P=0.128 P<0.001 ** P=0.053 P=0.036 * |
|POLY 6 | P=0.335 P=0.101 P=0.067 P=0.398 |P=0.075 P<0.001 ** P=0.027 * P=0.021 * |
|LOGISTIC REGRESSION| P=0.460 P=0.136 P=0.082 P=0.617 |P=0.077 P<0.001 ** P=0.022 * P=0.017 * |
|COCH-ARM / FISHERS | P=0.533 P=0.134 P=0.080 P=0.500 |P=0.152 P=0.004 ** P=0.097 P=0.044 * |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Necrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 3/50 (6%) 5/50 (10%) 4/50 (8%) |2/50 (4%) 6/50 (12%) 9/50 (18%) 5/50 (10%) |
|POLY-3 RATE (b) | 8/46.87 3/44.16 5/47.15 4/41.48 |2/45.74 6/43.38 9/43.00 5/45.02 |
|POLY-3 PERCENT (g) | 17.1% 6.8% 10.6% 9.6% |4.4% 13.8% 20.9% 11.1% |
|TERMINAL (d) | 6/39 (15%) 2/33 (6%) 2/36 (6%) 1/27 (4%) |1/38 (3%) 1/32 (3%) 4/30 (13%) 3/32 (9%) |
|FIRST INCIDENCE | 710 714 534 573 |683 446 270 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.374N P=0.160N P=0.326N P=0.383N |P=0.214 P=0.103 P=0.016 * P=0.182 |
|POLY 3 | P=0.249N P=0.118N P=0.272N P=0.241N |P=0.236 P=0.116 P=0.019 * P=0.210 |
|POLY 1.5 | P=0.234N P=0.110N P=0.274N P=0.214N |P=0.254 P=0.120 P=0.021 * P=0.218 |
|POLY 6 | P=0.267N P=0.128N P=0.270N P=0.278N |P=0.215 P=0.112 P=0.017 * P=0.198 |
|LOGISTIC REGRESSION| P=0.199N P=0.138N P=0.263N P=0.211N |P=0.218 P=0.143 P=0.037 * P=0.199 |
|COCH-ARM / FISHERS | P=0.213N P=0.100N P=0.277N P=0.178N |P=0.246 P=0.134 P=0.026 * P=0.218 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Hemosiderin |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) 1/50 (2%) |1/50 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 3/46.03 1/40.35 |1/45.73 0/41.52 2/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 6.5% 2.5% |2.2% 0.0% 5.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 1/36 (3%) 1/27 (4%) |0/38 (0%) 0/32 (0%) 2/30 (7%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- 695 729 (T) |686 --- 731 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.168 (e) P=0.115 P=0.427 |P=0.491N P=0.536N P=0.424 P=0.515N |
|POLY 3 | P=0.186 (e) P=0.116 P=0.471 |P=0.461N P=0.519N P=0.453 P=0.510N |
|POLY 1.5 | P=0.210 (e) P=0.117 P=0.483 |P=0.456N P=0.513N P=0.470 P=0.504N |
|POLY 6 | P=0.157 (e) P=0.114 P=0.455 |P=0.468N P=0.527N P=0.439 P=0.517N |
|LOGISTIC REGRESSION| P=0.192 (e) P=0.118 P=0.427 |P=0.473N P=0.504N P=0.451 P=0.500N |
|COCH-ARM / FISHERS | P=0.247 (e) P=0.121 P=0.500 |P=0.461N P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Liver |
| Tension Lipidosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 2/50 (4%) 3/50 (6%) |2/50 (4%) 4/50 (8%) 1/50 (2%) 2/50 (4%) |
|POLY-3 RATE (b) | 2/46.78 4/44.10 2/46.66 3/40.48 |2/45.74 4/42.20 1/40.57 2/43.48 |
|POLY-3 PERCENT (g) | 4.3% 9.1% 4.3% 7.4% |4.4% 9.5% 2.5% 4.6% |
|TERMINAL (d) | 2/39 (5%) 4/33 (12%) 1/36 (3%) 2/27 (7%) |1/38 (3%) 2/32 (6%) 0/30 (0%) 2/32 (6%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 422 695 |681 522 534 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.372 P=0.262 P=0.672 P=0.335 |P=0.475N P=0.277 P=0.566N P=0.635 |
|POLY 3 | P=0.450 P=0.310 P=0.693 P=0.435 |P=0.459N P=0.301 P=0.542N P=0.676 |
|POLY 1.5 | P=0.479 P=0.321 P=0.694N P=0.462 |P=0.444N P=0.311 P=0.527N P=0.687 |
|POLY 6 | P=0.415 P=0.297 P=0.690 P=0.401 |P=0.477N P=0.288 P=0.554N P=0.662 |
|LOGISTIC REGRESSION| P=0.503 P=0.262 P=0.658N P=0.363 |P=0.431N P=0.326 P=0.485N P=0.674 |
|COCH-ARM / FISHERS | P=0.521 P=0.339 P=0.691N P=0.500 |P=0.431N P=0.339 P=0.500N P=0.691N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 3/50 (6%) 1/50 (2%) |4/50 (8%) 3/50 (6%) 4/50 (8%) 4/50 (8%) |
|POLY-3 RATE (b) | 2/46.85 3/44.10 3/45.85 1/40.35 |4/45.55 3/41.52 4/40.29 4/43.48 |
|POLY-3 PERCENT (g) | 4.3% 6.8% 6.5% 2.5% |8.8% 7.2% 9.9% 9.2% |
|TERMINAL (d) | 1/39 (3%) 3/33 (9%) 3/36 (8%) 1/27 (4%) |4/38 (11%) 3/32 (9%) 2/30 (7%) 4/32 (13%) |
|FIRST INCIDENCE | 710 729 (T) 729 (T) 729 (T) |731 (T) 731 (T) 646 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.484N P=0.430 P=0.464 P=0.632N |P=0.434 P=0.594N P=0.516 P=0.547 |
|POLY 3 | P=0.411N P=0.472 P=0.490 P=0.552N |P=0.502 P=0.550N P=0.574 P=0.618 |
|POLY 1.5 | P=0.383N P=0.484 P=0.494 P=0.530N |P=0.518 P=0.536N P=0.599 P=0.634 |
|POLY 6 | P=0.449N P=0.459 P=0.484 P=0.580N |P=0.485 P=0.569N P=0.556 P=0.599 |
|LOGISTIC REGRESSION| P=0.482N P=0.448 P=0.477 P=0.608N |P=0.474 P=0.594N P=0.556 P=0.547 |
|COCH-ARM / FISHERS | P=0.343N P=0.500 P=0.500 P=0.500N |P=0.518 P=0.500N P=0.643N P=0.643N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 42/50 (84%) 45/50 (90%) 47/50 (94%) |4/50 (8%) 37/50 (74%) 39/50 (78%) 49/50 (98%) |
|POLY-3 RATE (b) | 6/46.85 42/48.01 45/48.50 47/48.74 |4/45.93 37/47.09 39/45.22 49/50.00 |
|POLY-3 PERCENT (g) | 12.8% 87.5% 92.8% 96.4% |8.7% 78.6% 86.2% 98.0% |
|TERMINAL (d) | 5/39 (13%) 30/33 (91%) 34/36 (94%) 27/27 (100%)|2/38 (5%) 26/32 (81%) 27/30 (90%) 31/32 (97%) |
|FIRST INCIDENCE | 710 405 534 387 |681 23 251 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 41/50 (82%) 49/50 (98%) 50/50 (100%)|0/50 (0%) 31/50 (62%) 38/50 (76%) 50/50 (100%) |
|POLY-3 RATE (b) | 3/46.78 41/48.96 49/49.96 50/50.00 |0/45.55 31/44.06 38/43.14 50/50.00 |
|POLY-3 PERCENT (g) | 6.4% 83.7% 98.1% 100.0% |0.0% 70.4% 88.1% 100.0% |
|TERMINAL (d) | 3/39 (8%) 29/33 (88%) 36/36 (100%) 27/27 (100%)|0/38 (0%) 23/32 (72%) 28/30 (93%) 32/32 (100%) |
|FIRST INCIDENCE | 729 (T) 405 422 387 |--- 522 416 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 36/50 (72%) 45/50 (90%) 49/50 (98%) |0/50 (0%) 34/50 (68%) 35/50 (70%) 45/50 (90%) |
|POLY-3 RATE (b) | 10/47.09 36/47.41 45/48.78 49/49.42 |0/45.55 34/44.18 35/42.55 45/48.32 |
|POLY-3 PERCENT (g) | 21.2% 75.9% 92.3% 99.2% |0.0% 77.0% 82.3% 93.1% |
|TERMINAL (d) | 8/39 (21%) 26/33 (79%) 33/36 (92%) 27/27 (100%)|0/38 (0%) 25/32 (78%) 25/30 (83%) 29/32 (91%) |
|FIRST INCIDENCE | 667 530 534 387 |--- 522 534 542 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung: Bronchiole, Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 15/50 (30%) 37/50 (74%) 46/50 (92%) |0/50 (0%) 12/50 (24%) 34/50 (68%) 48/50 (96%) |
|POLY-3 RATE (b) | 0/46.78 15/44.85 37/48.30 46/49.67 |0/45.55 12/41.52 34/45.57 48/49.98 |
|POLY-3 PERCENT (g) | 0.0% 33.4% 76.6% 92.6% |0.0% 28.9% 74.6% 96.0% |
|TERMINAL (d) | 0/39 (0%) 13/33 (39%) 30/36 (83%) 25/27 (93%) |0/38 (0%) 12/32 (38%) 24/30 (80%) 31/32 (97%) |
|FIRST INCIDENCE | --- 530 422 387 |--- 731 (T) 270 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung: Interstitium |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 6/50 (12%) 9/50 (18%) 12/50 (24%) |0/50 (0%) 1/50 (2%) 4/50 (8%) 8/50 (16%) |
|POLY-3 RATE (b) | 1/46.78 6/45.61 9/47.57 12/42.68 |0/45.55 1/41.52 4/40.15 8/44.03 |
|POLY-3 PERCENT (g) | 2.1% 13.2% 18.9% 28.1% |0.0% 2.4% 10.0% 18.2% |
|TERMINAL (d) | 1/39 (3%) 2/33 (6%) 2/36 (6%) 5/27 (19%) |0/38 (0%) 1/32 (3%) 2/30 (7%) 4/32 (13%) |
|FIRST INCIDENCE | 729 (T) 534 534 494 |--- 731 (T) 705 639 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.047 * P=0.011 * P<0.001 ** |P<0.001 ** P=0.466 P=0.043 * P=0.004 ** |
|POLY 3 | P<0.001 ** P=0.052 P=0.009 ** P<0.001 ** |P<0.001 ** P=0.482 P=0.046 * P=0.003 ** |
|POLY 1.5 | P<0.001 ** P=0.054 P=0.008 ** P<0.001 ** |P<0.001 ** P=0.487 P=0.051 P=0.003 ** |
|POLY 6 | P<0.001 ** P=0.050 P=0.009 ** P<0.001 ** |P<0.001 ** P=0.475 P=0.042 * P=0.003 ** |
|LOGISTIC REGRESSION| P=0.003 ** P=0.083 P=0.011 * P=0.002 ** |P<0.001 ** P=0.466 P=0.044 * P=0.004 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.056 P=0.008 ** P<0.001 ** |P<0.001 ** P=0.500 P=0.059 P=0.003 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lung: Perivascular |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 0/45.85 0/40.35 |2/45.55 2/41.52 3/40.55 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |4.4% 4.8% 7.4% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |2/38 (5%) 2/32 (6%) 1/30 (3%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |731 (T) 731 (T) 577 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.243N P=0.632 P=0.407 P=0.277N |
|POLY 3 | (e) (e) (e) (e) |P=0.209N P=0.660 P=0.447 P=0.248N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.200N P=0.670 P=0.466 P=0.241N |
|POLY 6 | (e) (e) (e) (e) |P=0.219N P=0.648 P=0.434 P=0.255N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.207N P=0.632 P=0.472 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.199N P=0.691N P=0.500 P=0.247N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lymph Node |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/1 (0%) |3/3 (100%) 1/1 (100%) 0/5 (0%) 0/1 (0%) |
|POLY-3 RATE (b) | 0/0.00 0/0.67 0/0.00 0/0.52 |3/3.00 1/1.00 0/4.89 0/0.71 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |100.0% 100.0% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |3/3 (100%) 1/1 (100%) 0/3 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- |731 (T) 731 (T) --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.063N (e) P=0.068N P=1.000N |
|POLY 3 | (e) (e) (e) (e) |P<0.001N** (e) P<0.001N** P=1.000N |
|POLY 1.5 | (e) (e) (e) (e) |P<0.001N** (e) P<0.001N** P<0.001N** |
|POLY 6 | (e) (e) (e) (e) |P<0.001N** (e) P<0.001N** P=1.000N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.063N (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.016N* (e) P=0.018N* P=0.250N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lymph Node, Bronchial |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 7/40 (18%) 7/38 (18%) 12/36 (33%) 13/40 (33%) |3/39 (8%) 13/40 (33%) 14/45 (31%) 20/41 (49%) |
|POLY-3 RATE (b) | 7/38.85 7/34.54 12/34.77 13/35.33 |3/36.66 13/36.01 14/37.77 20/39.30 |
|POLY-3 PERCENT (g) | 18.0% 20.3% 34.5% 36.8% |8.2% 36.1% 37.1% 50.9% |
|TERMINAL (d) | 6/33 (18%) 2/23 (9%) 8/27 (30%) 4/21 (19%) |3/31 (10%) 9/25 (36%) 9/28 (32%) 9/25 (36%) |
|FIRST INCIDENCE | 667 530 617 494 |731 (T) 522 577 542 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.010 * P=0.421 P=0.083 P=0.024 * |P<0.001 ** P=0.002 ** P=0.002 ** P<0.001 ** |
|POLY 3 | P=0.026 * P=0.521 P=0.087 P=0.057 |P<0.001 ** P=0.003 ** P=0.002 ** P<0.001 ** |
|POLY 1.5 | P=0.033 * P=0.541 P=0.089 P=0.071 |P<0.001 ** P=0.004 ** P=0.003 ** P<0.001 ** |
|POLY 6 | P=0.019 * P=0.499 P=0.085 P=0.044 * |P<0.001 ** P=0.003 ** P=0.002 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.078 P=0.567N P=0.099 P=0.167 |P<0.001 ** P=0.006 ** P=0.003 ** P<0.001 ** |
|COCH-ARM / FISHERS | P=0.047 * P=0.574 P=0.092 P=0.098 |P<0.001 ** P=0.006 ** P=0.007 ** P<0.001 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/34 (3%) 0/43 (0%) 1/27 (4%) 1/35 (3%) |0/41 (0%) 2/40 (5%) 1/40 (3%) 3/46 (7%) |
|POLY-3 RATE (b) | 1/31.74 0/38.91 1/24.86 1/28.33 |0/38.25 2/33.97 1/31.83 3/40.06 |
|POLY-3 PERCENT (g) | 3.2% 0.0% 4.0% 3.5% |0.0% 5.9% 3.1% 7.5% |
|TERMINAL (d) | 1/27 (4%) 0/30 (0%) 0/18 (0%) 1/18 (6%) |0/32 (0%) 2/26 (8%) 1/24 (4%) 2/30 (7%) |
|FIRST INCIDENCE | 729 (T) --- 639 729 (T) |--- 731 (T) 731 (T) 705 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.440 P=0.479N P=0.716 P=0.669 |P=0.106 P=0.193 P=0.443 P=0.111 |
|POLY 3 | P=0.475 P=0.459N P=0.705 P=0.735 |P=0.115 P=0.211 P=0.464 P=0.126 |
|POLY 1.5 | P=0.493 P=0.457N P=0.707 P=0.749 |P=0.122 P=0.216 P=0.474 P=0.132 |
|POLY 6 | P=0.450 P=0.461N P=0.703 P=0.715 |P=0.107 P=0.203 P=0.454 P=0.120 |
|LOGISTIC REGRESSION| P=0.509 (e) P=0.724 P=0.669 |P=0.116 P=0.193 P=0.443 P=0.121 |
|COCH-ARM / FISHERS | P=0.518 P=0.442N P=0.693 P=0.746N |P=0.131 P=0.241 P=0.494 P=0.143 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/38 (5%) 3/36 (8%) 4/43 (9%) 6/37 (16%) |6/43 (14%) 4/37 (11%) 5/42 (12%) 6/42 (14%) |
|POLY-3 RATE (b) | 2/36.05 3/32.08 4/40.87 6/30.64 |6/41.29 4/33.07 5/35.75 6/38.04 |
|POLY-3 PERCENT (g) | 5.6% 9.4% 9.8% 19.6% |14.5% 12.1% 14.0% 15.8% |
|TERMINAL (d) | 1/30 (3%) 2/26 (8%) 1/33 (3%) 2/20 (10%) |4/35 (11%) 4/25 (16%) 3/28 (11%) 2/27 (7%) |
|FIRST INCIDENCE | 667 639 639 535 |662 731 (T) 577 550 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.032 * P=0.442 P=0.344 P=0.058 |P=0.387 P=0.571N P=0.607 P=0.499 |
|POLY 3 | P=0.053 P=0.447 P=0.396 P=0.083 |P=0.465 P=0.514N P=0.601N P=0.563 |
|POLY 1.5 | P=0.062 P=0.457 P=0.396 P=0.097 |P=0.475 P=0.493N P=0.577N P=0.577 |
|POLY 6 | P=0.045 * P=0.436 P=0.396 P=0.067 |P=0.454 P=0.543N P=0.616N P=0.545 |
|LOGISTIC REGRESSION| P=0.085 P=0.483 P=0.392 P=0.135 |P=0.478 P=0.517N P=0.548N P=0.616 |
|COCH-ARM / FISHERS | P=0.075 P=0.474 P=0.399 P=0.122 |P=0.500 P=0.469N P=0.517N P=0.605 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 1/47 (2%) 2/48 (4%) 0/44 (0%) |0/46 (0%) 0/47 (0%) 0/48 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/43.55 1/42.75 2/44.46 0/36.08 |0/41.55 0/41.52 0/39.58 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 4.5% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/33 (0%) 1/35 (3%) 0/26 (0%) |0/34 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- 639 639 --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.641 P=0.486 P=0.234 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.603 P=0.496 P=0.242 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.635 P=0.499 P=0.244 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.562 P=0.493 P=0.239 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.576N P=0.572 P=0.263 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.629N P=0.505 P=0.258 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/46 (7%) 7/47 (15%) 2/48 (4%) 2/44 (5%) |2/46 (4%) 1/47 (2%) 1/48 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 3/43.55 7/42.54 2/44.13 2/36.08 |2/41.55 1/41.86 1/39.58 1/43.48 |
|POLY-3 PERCENT (g) | 6.9% 16.5% 4.5% 5.5% |4.8% 2.4% 2.5% 2.3% |
|TERMINAL (d) | 3/37 (8%) 5/33 (15%) 2/35 (6%) 2/26 (8%) |2/34 (6%) 0/32 (0%) 1/30 (3%) 1/32 (3%) |
|FIRST INCIDENCE | 729 (T) 714 729 (T) 729 (T) |731 (T) 635 731 (T) 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.341N P=0.120 P=0.526N P=0.659N |P=0.431N P=0.530N P=0.544N P=0.521N |
|POLY 3 | P=0.273N P=0.147 P=0.494N P=0.585N |P=0.395N P=0.497N P=0.517N P=0.484N |
|POLY 1.5 | P=0.249N P=0.154 P=0.489N P=0.559N |P=0.390N P=0.490N P=0.504N P=0.475N |
|POLY 6 | P=0.304N P=0.139 P=0.501N P=0.616N |P=0.400N P=0.506N P=0.527N P=0.494N |
|LOGISTIC REGRESSION| P=0.342N P=0.130 P=0.526N P=0.659N |P=0.396N P=0.492N P=0.544N P=0.521N |
|COCH-ARM / FISHERS | P=0.215N P=0.167 P=0.480N P=0.521N |P=0.383N P=0.492N P=0.484N P=0.468N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) |3/50 (6%) 0/50 (0%) 4/50 (8%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/0.00 0/0.00 0/0.00 0/1.00 |3/45.55 0/41.52 4/40.77 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |6.6% 0.0% 9.8% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) |3/38 (8%) 0/32 (0%) 3/30 (10%) 0/32 (0%) |
|FIRST INCIDENCE | --- --- --- --- |731 (T) --- 416 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.240N P=0.153N P=0.386 P=0.153N |
|POLY 3 | (e) (e) (e) (e) |P=0.194N P=0.136N P=0.440 P=0.127N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.189N P=0.131N P=0.462 P=0.122N |
|POLY 6 | (e) (e) (e) (e) |P=0.200N P=0.143N P=0.422 P=0.133N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.200N (e) P=0.482 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.199N P=0.121N P=0.500 P=0.121N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/9 (33%) 0/7 (0%) 3/8 (38%) 0/1 (0%) |1/14 (7%) 1/9 (11%) 1/5 (20%) 0/4 (0%) |
|POLY-3 RATE (b) | 3/9.00 0/6.23 3/7.59 0/1.00 |1/13.59 1/8.68 1/4.51 0/3.11 |
|POLY-3 PERCENT (g) | 33.3% 0.0% 39.6% 0.0% |7.4% 11.5% 22.2% 0.0% |
|TERMINAL (d) | 3/9 (33%) 0/5 (0%) 3/6 (50%) 0/1 (0%) |1/12 (8%) 1/7 (14%) 0/3 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 729 (T) --- 729 (T) --- |731 (T) 731 (T) 662 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.670 P=0.227N P=0.459 P=0.669N |P=0.687 P=0.640 P=0.599 P=1.000N |
|POLY 3 | P=0.604N P=0.167N P=0.593 P=0.663N |P=0.622 P=0.658 P=0.499 P=0.769N |
|POLY 1.5 | P=0.599N P=0.154N P=0.607 P=0.663N |P=0.651N P=0.659 P=0.506 P=0.759N |
|POLY 6 | P=0.614N P=0.188N P=0.570 P=0.663N |P=0.556 P=0.657 P=0.490 P=0.783N |
|LOGISTIC REGRESSION| P=0.670 (e) P=0.459 (e) |P=0.631N P=0.640 P=0.635 (e) |
|COCH-ARM / FISHERS | P=0.595N P=0.150N P=0.627 P=0.700N |P=0.631N P=0.640 P=0.468 P=0.778N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/9 (56%) 3/7 (43%) 4/8 (50%) 1/1 (100%) |11/14 (79%) 9/9 (100%) 5/5 (100%) 3/4 (75%) |
|POLY-3 RATE (b) | 5/9.00 3/6.23 4/7.59 1/1.00 |11/13.68 9/9.00 5/5.00 3/3.43 |
|POLY-3 PERCENT (g) | 55.6% 48.2% 52.7% 100.0% |80.4% 100.0% 100.0% 87.6% |
|TERMINAL (d) | 5/9 (56%) 3/5 (60%) 4/6 (67%) 1/1 (100%) |10/12 (83%) 7/7 (100%) 3/3 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |709 660 584 653 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.341 P=0.651 P=0.541 P=0.581 |P=0.145 P=0.218 P=0.299 P=0.267 |
|POLY 3 | P=0.482 P=0.589N P=0.641N P=0.579 |P=0.337 P=0.217 P=0.371 P=0.678 |
|POLY 1.5 | P=0.494 P=0.548N P=0.619N P=0.579 |P=0.447 P=0.206 P=0.357 P=0.728 |
|POLY 6 | P=0.460 P=0.648N P=0.676N P=0.579 |P=0.231 P=0.240 P=0.396 P=0.614 |
|LOGISTIC REGRESSION| P=0.341 P=0.651 P=0.541 P=0.581 |P=0.188 P=0.173 P=0.235 P=0.342 |
|COCH-ARM / FISHERS | P=0.506 P=0.500N P=0.601N P=0.600 |P=0.601 P=0.206 P=0.376 P=0.673N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 11/50 (22%) 32/50 (64%) 23/50 (46%) |19/50 (38%) 14/50 (28%) 32/50 (64%) 30/50 (60%) |
|POLY-3 RATE (b) | 16/47.91 11/46.00 32/47.92 23/42.47 |19/48.01 14/42.69 32/45.50 30/45.44 |
|POLY-3 PERCENT (g) | 33.4% 23.9% 66.8% 54.2% |39.6% 32.8% 70.3% 66.0% |
|TERMINAL (d) | 12/39 (31%) 7/33 (21%) 26/36 (72%) 16/27 (59%) |13/38 (34%) 11/32 (34%) 20/30 (67%) 24/32 (75%) |
|FIRST INCIDENCE | 499 514 422 546 |181 522 251 478 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.325N P<0.001 ** P=0.007 ** |P<0.001 ** P=0.388N P=0.002 ** P=0.006 ** |
|POLY 3 | P<0.001 ** P=0.215N P<0.001 ** P=0.034 * |P<0.001 ** P=0.326N P=0.002 ** P=0.007 ** |
|POLY 1.5 | P=0.003 ** P=0.202N P<0.001 ** P=0.056 |P<0.001 ** P=0.288N P=0.003 ** P=0.012 * |
|POLY 6 | P<0.001 ** P=0.235N P<0.001 ** P=0.018 * |P<0.001 ** P=0.375N P<0.001 ** P=0.004 ** |
|LOGISTIC REGRESSION| P=0.006 ** P=0.154N P<0.001 ** P=0.036 * |P=0.002 ** P=0.223N P=0.008 ** P=0.021 * |
|COCH-ARM / FISHERS | P=0.014 * P=0.184N P<0.001 ** P=0.109 |P=0.002 ** P=0.198N P=0.008 ** P=0.022 * |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 1/44.75 1/46.66 0/40.35 |0/45.55 0/41.52 2/41.53 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 2.1% 0.0% |0.0% 0.0% 4.8% 0.0% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- 514 422 --- |--- --- 251 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.603N P=0.500 P=0.500 (e) |P=0.602 (e) P=0.232 (e) |
|POLY 3 | P=0.632N P=0.491 P=0.499 (e) |P=0.588 (e) P=0.217 (e) |
|POLY 1.5 | P=0.617N P=0.495 P=0.500 (e) |P=0.599 (e) P=0.225 (e) |
|POLY 6 | P=0.650N P=0.487 P=0.498 (e) |P=0.576 (e) P=0.211 (e) |
|LOGISTIC REGRESSION| P=0.257N P=0.715 (e) (e) |P=0.494 (e) P=0.226 (e) |
|COCH-ARM / FISHERS | P=0.595N P=0.500 P=0.500 (e) |P=0.595 (e) P=0.247 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Lateral Wall |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 2/45.85 1/40.35 |0/45.55 0/41.52 1/40.45 2/43.59 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.4% 2.5% |0.0% 0.0% 2.5% 4.6% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 2/36 (6%) 1/27 (4%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- --- 729 (T) 729 (T) |--- --- 584 705 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.177 (e) P=0.221 P=0.427 |P=0.066 (e) P=0.468 P=0.213 |
|POLY 3 | P=0.196 (e) P=0.233 P=0.471 |P=0.069 (e) P=0.476 P=0.227 |
|POLY 1.5 | P=0.216 (e) P=0.235 P=0.483 |P=0.071 (e) P=0.485 P=0.234 |
|POLY 6 | P=0.172 (e) P=0.230 P=0.455 |P=0.066 (e) P=0.470 P=0.221 |
|LOGISTIC REGRESSION| (e) (e) P=0.221 P=0.427 |P=0.070 (e) P=0.519 P=0.223 |
|COCH-ARM / FISHERS | P=0.246 (e) P=0.247 P=0.500 |P=0.070 (e) P=0.500 P=0.247 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Lateral Wall |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |1/50 (2%) 1/50 (2%) 4/50 (8%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/46.78 1/44.75 1/45.99 1/40.48 |1/45.55 1/42.15 4/42.44 1/43.48 |
|POLY-3 PERCENT (g) | 0.0% 2.2% 2.2% 2.5% |2.2% 2.4% 9.4% 2.3% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |1/38 (3%) 0/32 (0%) 1/30 (3%) 1/32 (3%) |
|FIRST INCIDENCE | --- 514 695 695 |731 (T) 522 251 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.321 P=0.500 P=0.495 P=0.421 |P=0.507 P=0.739 P=0.152 P=0.723 |
|POLY 3 | P=0.331 P=0.491 P=0.497 P=0.471 |P=0.510 P=0.743 P=0.158 P=0.750 |
|POLY 1.5 | P=0.353 P=0.495 P=0.498 P=0.483 |P=0.526 P=0.748 P=0.167 P=0.757 |
|POLY 6 | P=0.304 P=0.487 P=0.495 P=0.456 |P=0.493 P=0.737 P=0.151 P=0.743 |
|LOGISTIC REGRESSION| P=0.489 P=0.715 P=0.505 P=0.490 |P=0.466 P=0.750N P=0.215 P=0.723 |
|COCH-ARM / FISHERS | P=0.384 P=0.500 P=0.500 P=0.500 |P=0.526 P=0.753N P=0.181 P=0.753N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 7/50 (14%) 9/50 (18%) 12/50 (24%) |2/50 (4%) 8/50 (16%) 5/50 (10%) 14/50 (28%) |
|POLY-3 RATE (b) | 6/46.90 7/45.07 9/47.77 12/43.03 |2/46.48 8/41.88 5/39.96 14/45.73 |
|POLY-3 PERCENT (g) | 12.8% 15.5% 18.8% 27.9% |4.3% 19.1% 12.5% 30.6% |
|TERMINAL (d) | 5/39 (13%) 3/33 (9%) 4/36 (11%) 7/27 (26%) |0/38 (0%) 5/32 (16%) 5/30 (17%) 5/32 (16%) |
|FIRST INCIDENCE | 698 514 422 387 |505 668 731 (T) 542 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.016 * P=0.396 P=0.258 P=0.025 * |P<0.001 ** P=0.031 * P=0.142 P<0.001 ** |
|POLY 3 | P=0.037 * P=0.469 P=0.301 P=0.062 |P<0.001 ** P=0.030 * P=0.160 P<0.001 ** |
|POLY 1.5 | P=0.044 * P=0.481 P=0.297 P=0.075 |P<0.001 ** P=0.034 * P=0.180 P<0.001 ** |
|POLY 6 | P=0.029 * P=0.455 P=0.303 P=0.047 * |P<0.001 ** P=0.025 * P=0.144 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.100 P=0.491 P=0.316 P=0.123 |P<0.001 ** P=0.042 * P=0.198 P<0.001 ** |
|COCH-ARM / FISHERS | P=0.056 P=0.500 P=0.288 P=0.096 |P<0.001 ** P=0.046 * P=0.218 P<0.001 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Degeneration Hyaline |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 7/50 (14%) 23/50 (46%) 30/50 (60%) |11/50 (22%) 23/50 (46%) 34/50 (68%) 48/50 (96%) |
|POLY-3 RATE (b) | 1/46.78 7/44.79 23/47.66 30/45.45 |11/46.79 23/43.40 34/45.52 48/49.05 |
|POLY-3 PERCENT (g) | 2.1% 15.6% 48.3% 66.0% |23.5% 53.0% 74.7% 97.9% |
|TERMINAL (d) | 1/39 (3%) 4/33 (12%) 16/36 (44%) 17/27 (63%) |8/38 (21%) 19/32 (59%) 22/30 (73%) 32/32 (100%) |
|FIRST INCIDENCE | 729 (T) 558 422 394 |181 564 270 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P=0.022 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.026 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.027 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.024 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.030 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.006 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.030 * P<0.001 ** P<0.001 ** |P<0.001 ** P=0.010 * P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Degeneration Hyaline |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 22/50 (44%) 38/50 (76%) 41/50 (82%) |35/50 (70%) 39/50 (78%) 46/50 (92%) 50/50 (100%) |
|POLY-3 RATE (b) | 8/46.90 22/45.57 38/48.06 41/46.11 |35/47.67 39/44.36 46/47.42 50/50.00 |
|POLY-3 PERCENT (g) | 17.1% 48.3% 79.1% 88.9% |73.4% 87.9% 97.0% 100.0% |
|TERMINAL (d) | 7/39 (18%) 15/33 (46%) 28/36 (78%) 25/27 (93%) |27/38 (71%) 29/32 (91%) 29/30 (97%) 32/32 (100%) |
|FIRST INCIDENCE | 698 558 534 541 |505 564 270 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.046 * P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.062 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.093 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.037 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.081 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.002 ** P<0.001 ** P<0.001 ** |P<0.001 ** P=0.247 P=0.005 ** P<0.001 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 30
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 6/50 (12%) 6/50 (12%) 2/50 (4%) |0/50 (0%) 3/50 (6%) 7/50 (14%) 8/50 (16%) |
|POLY-3 RATE (b) | 0/46.78 6/46.24 6/46.70 2/40.48 |0/45.55 3/42.25 7/40.90 8/44.29 |
|POLY-3 PERCENT (g) | 0.0% 13.0% 12.9% 4.9% |0.0% 7.1% 17.1% 18.1% |
|TERMINAL (d) | 0/39 (0%) 2/33 (6%) 4/36 (11%) 1/27 (4%) |0/38 (0%) 1/32 (3%) 5/30 (17%) 5/32 (16%) |
|FIRST INCIDENCE | --- 514 422 695 |--- 522 318 565 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.335 P=0.016 * P=0.016 * P=0.161 |P=0.002 ** P=0.105 P=0.005 ** P=0.003 ** |
|POLY 3 | P=0.330 P=0.015 * P=0.015 * P=0.207 |P=0.002 ** P=0.106 P=0.005 ** P=0.003 ** |
|POLY 1.5 | P=0.383 P=0.015 * P=0.015 * P=0.219 |P=0.002 ** P=0.109 P=0.006 ** P=0.003 ** |
|POLY 6 | P=0.267 P=0.014 * P=0.015 * P=0.192 |P=0.002 ** P=0.102 P=0.004 ** P=0.003 ** |
|LOGISTIC REGRESSION| P=0.534N P=0.035 * P=0.020 * P=0.191 |P=0.003 ** P=0.124 P=0.009 ** P=0.005 ** |
|COCH-ARM / FISHERS | P=0.463 P=0.013 * P=0.013 * P=0.247 |P=0.003 ** P=0.121 P=0.006 ** P=0.003 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 7/50 (14%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 1/45.85 2/40.35 |0/45.55 0/41.52 1/40.57 7/44.19 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.2% 5.0% |0.0% 0.0% 2.5% 15.8% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 1/36 (3%) 2/27 (7%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 5/32 (16%) |
|FIRST INCIDENCE | --- --- 729 (T) 729 (T) |--- --- 534 565 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.040 * (e) P=0.484 P=0.162 |P<0.001 ** (e) P=0.478 P=0.006 ** |
|POLY 3 | P=0.057 (e) P=0.496 P=0.206 |P<0.001 ** (e) P=0.477 P=0.007 ** |
|POLY 1.5 | P=0.062 (e) P=0.498 P=0.219 |P<0.001 ** (e) P=0.485 P=0.007 ** |
|POLY 6 | P=0.051 (e) P=0.494 P=0.190 |P<0.001 ** (e) P=0.471 P=0.006 ** |
|LOGISTIC REGRESSION| (e) (e) P=0.484 P=0.162 |P<0.001 ** (e) P=0.519 P=0.009 ** |
|COCH-ARM / FISHERS | P=0.070 (e) P=0.500 P=0.247 |P<0.001 ** (e) P=0.500 P=0.006 ** |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 31
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |16/48 (33%) 16/50 (32%) 15/49 (31%) 17/47 (36%) |
|POLY-3 RATE (b) | |16/44.95 16/42.39 15/41.59 17/43.22 |
|POLY-3 PERCENT (g) | |35.6% 37.7% 36.1% 39.3% |
|TERMINAL (d) | |13/37 (35%) 11/32 (34%) 10/30 (33%) 8/29 (28%) |
|FIRST INCIDENCE | |505 603 490 550 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.255 P=0.396 P=0.415 P=0.280 |
|POLY 3 | |P=0.411 P=0.506 P=0.571 P=0.443 |
|POLY 1.5 | |P=0.429 P=0.547 P=0.554N P=0.467 |
|POLY 6 | |P=0.400 P=0.457 P=0.532 P=0.424 |
|LOGISTIC REGRESSION| |P=0.389 P=0.527 P=0.564N P=0.461 |
|COCH-ARM / FISHERS | |P=0.411 P=0.530N P=0.472N P=0.470 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Pancreas |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 5/50 (10%) 2/50 (4%) |3/50 (6%) 4/50 (8%) 2/49 (4%) 4/50 (8%) |
|POLY-3 RATE (b) | 3/46.90 3/44.10 5/46.46 2/40.35 |3/45.92 4/41.52 2/39.90 4/43.59 |
|POLY-3 PERCENT (g) | 6.4% 6.8% 10.8% 5.0% |6.5% 9.6% 5.0% 9.2% |
|TERMINAL (d) | 2/39 (5%) 3/33 (9%) 4/36 (11%) 2/27 (7%) |2/38 (5%) 4/32 (13%) 2/30 (7%) 3/32 (9%) |
|FIRST INCIDENCE | 698 729 (T) 534 729 (T) |626 731 (T) 731 (T) 705 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.551 P=0.584 P=0.321 P=0.668N |P=0.405 P=0.408 P=0.602N P=0.418 |
|POLY 3 | P=0.527N P=0.634 P=0.351 P=0.568N |P=0.455 P=0.445 P=0.564N P=0.472 |
|POLY 1.5 | P=0.492N P=0.645 P=0.354 P=0.540N |P=0.472 P=0.462 P=0.542N P=0.489 |
|POLY 6 | P=0.560 P=0.619 P=0.346 P=0.604N |P=0.435 P=0.424 P=0.582N P=0.452 |
|LOGISTIC REGRESSION| P=0.524N P=0.613 P=0.363 P=0.640N |P=0.448 P=0.447 P=0.552N P=0.481 |
|COCH-ARM / FISHERS | P=0.442N P=0.661N P=0.357 P=0.500N |P=0.479 P=0.500 P=0.510N P=0.500 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 32
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/33 (0%) 0/43 (0%) 0/44 (0%) 0/35 (0%) |0/42 (0%) 2/41 (5%) 0/43 (0%) 1/39 (3%) |
|POLY-3 RATE (b) | 0/31.22 0/39.13 0/40.52 0/28.58 |0/37.87 2/35.41 0/36.36 1/35.54 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 5.7% 0.0% 2.8% |
|TERMINAL (d) | 0/26 (0%) 0/31 (0%) 0/34 (0%) 0/20 (0%) |0/32 (0%) 2/31 (7%) 0/29 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- --- --- |--- 731 (T) --- 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.495 P=0.231 (e) P=0.466 |
|POLY 3 | (e) (e) (e) (e) |P=0.521 P=0.222 (e) P=0.487 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.527 P=0.222 (e) P=0.490 |
|POLY 6 | (e) (e) (e) (e) |P=0.515 P=0.221 (e) P=0.484 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) P=0.231 (e) P=0.466 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.523 P=0.241 (e) P=0.481 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/48 (6%) 3/49 (6%) 0/49 (0%) |2/49 (4%) 0/50 (0%) 1/50 (2%) 2/47 (4%) |
|POLY-3 RATE (b) | 2/46.92 3/42.16 3/44.85 0/39.35 |2/45.54 0/41.52 1/39.96 2/41.06 |
|POLY-3 PERCENT (g) | 4.3% 7.1% 6.7% 0.0% |4.4% 0.0% 2.5% 4.9% |
|TERMINAL (d) | 1/39 (3%) 2/32 (6%) 3/35 (9%) 0/26 (0%) |2/38 (5%) 0/32 (0%) 1/30 (3%) 2/30 (7%) |
|FIRST INCIDENCE | 692 715 729 (T) --- |731 (T) --- 731 (T) 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.265N P=0.424 P=0.457 P=0.334N |P=0.398 P=0.277N P=0.583N P=0.607 |
|POLY 3 | P=0.222N P=0.451 P=0.479 P=0.278N |P=0.454 P=0.258N P=0.545N P=0.656 |
|POLY 1.5 | P=0.198N P=0.464 P=0.484 P=0.263N |P=0.458 P=0.252N P=0.528N P=0.667 |
|POLY 6 | P=0.255N P=0.436 P=0.472 P=0.300N |P=0.449 P=0.267N P=0.559N P=0.645 |
|LOGISTIC REGRESSION| P=0.240N P=0.439 P=0.473 P=0.279N |P=0.398 (e) P=0.583N P=0.607 |
|COCH-ARM / FISHERS | P=0.168N P=0.480 P=0.490 P=0.253N |P=0.453 P=0.242N P=0.492N P=0.676 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 33
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/48 (6%) 0/49 (0%) 1/49 (2%) |22/49 (45%) 26/50 (52%) 15/50 (30%) 20/47 (43%) |
|POLY-3 RATE (b) | 4/47.53 3/42.27 0/44.85 1/39.35 |22/45.54 26/42.14 15/40.21 20/42.03 |
|POLY-3 PERCENT (g) | 8.4% 7.1% 0.0% 2.5% |48.3% 61.7% 37.3% 47.6% |
|TERMINAL (d) | 2/39 (5%) 1/32 (3%) 0/35 (0%) 1/26 (4%) |22/38 (58%) 23/32 (72%) 12/30 (40%) 13/30 (43%) |
|FIRST INCIDENCE | 499 695 --- 729 (T) |731 (T) 635 695 611 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.123N P=0.573N P=0.077N P=0.297N |P=0.524N P=0.053 P=0.350N P=0.387 |
|POLY 3 | P=0.083N P=0.564N P=0.068N P=0.242N |P=0.311N P=0.143 P=0.207N P=0.558N |
|POLY 1.5 | P=0.079N P=0.547N P=0.066N P=0.217N |P=0.284N P=0.178 P=0.160N P=0.526N |
|POLY 6 | P=0.088N P=0.582N P=0.071N P=0.275N |P=0.326N P=0.109 P=0.242N P=0.580N |
|LOGISTIC REGRESSION| P=0.069N P=0.489N P=0.052N P=0.153N |P=0.408N P=0.060 P=0.296N P=0.486 |
|COCH-ARM / FISHERS | P=0.073N P=0.523N P=0.061N P=0.187N |P=0.272N P=0.307 P=0.093N P=0.490N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Pleura: Mesothelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 4/4 (100%) 2/2 (100%) 1/2 (50%) |0/0 (0%) 1/1 (100%) 0/0 (0%) 1/1 (100%) |
|POLY-3 RATE (b) | 0/0.00 4/4.00 2/2.00 1/2.00 |0/0.00 1/1.00 0/0.00 1/1.00 |
|POLY-3 PERCENT (g) | 0.0% 100.0% 100.0% 50.0% |0.0% 100.0% 0.0% 100.0% |
|TERMINAL (d) | 0/0 (0%) 2/2 (100%) 1/1 (100%) 0/1 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) |
|FIRST INCIDENCE | --- 639 639 586 |--- 718 --- 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.579N (e) (e) P=0.471 |(e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.191N (e) (e) P=1.000 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 34
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Preputial Gland |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 19/50 (38%) 13/50 (26%) 20/49 (41%) | |
|POLY-3 RATE (b) | 15/45.91 19/46.22 13/46.03 20/41.77 | |
|POLY-3 PERCENT (g) | 32.7% 41.1% 28.2% 47.9% | |
|TERMINAL (d) | 14/39 (36%) 11/33 (33%) 11/36 (31%) 12/26 (46%) | |
|FIRST INCIDENCE | 701 514 695 535 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.033 * P=0.139 P=0.507N P=0.017 * | |
|POLY 3 | P=0.143 P=0.266 P=0.407N P=0.105 | |
|POLY 1.5 | P=0.177 P=0.273 P=0.399N P=0.137 | |
|POLY 6 | P=0.111 P=0.262 P=0.419N P=0.076 | |
|LOGISTIC REGRESSION| P=0.116 P=0.239 P=0.452N P=0.064 | |
|COCH-ARM / FISHERS | P=0.240 P=0.287 P=0.387N P=0.200 | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 5/50 (10%) 5/50 (10%) 3/49 (6%) | |
|POLY-3 RATE (b) | 2/45.91 5/44.58 5/46.46 3/39.35 | |
|POLY-3 PERCENT (g) | 4.4% 11.2% 10.8% 7.6% | |
|TERMINAL (d) | 1/39 (3%) 3/33 (9%) 4/36 (11%) 3/26 (12%) | |
|FIRST INCIDENCE | 701 590 534 729 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.332 P=0.169 P=0.195 P=0.321 | |
|POLY 3 | P=0.403 P=0.204 P=0.221 P=0.430 | |
|POLY 1.5 | P=0.449 P=0.212 P=0.223 P=0.459 | |
|POLY 6 | P=0.344 P=0.194 P=0.217 P=0.393 | |
|LOGISTIC REGRESSION| P=0.459 P=0.215 P=0.231 P=0.351 | |
|COCH-ARM / FISHERS | P=0.515 P=0.226 P=0.226 P=0.500 | |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 35
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/49 (4%) 0/49 (0%) 0/49 (0%) | |
|POLY-3 RATE (b) | 4/46.87 2/43.43 0/44.85 0/39.94 | |
|POLY-3 PERCENT (g) | 8.5% 4.6% 0.0% 0.0% | |
|TERMINAL (d) | 2/39 (5%) 1/33 (3%) 0/35 (0%) 0/27 (0%) | |
|FIRST INCIDENCE | 710 728 --- --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.032N* P=0.410N P=0.080N P=0.126N | |
|POLY 3 | P=0.019N* P=0.373N P=0.066N P=0.083N | |
|POLY 1.5 | P=0.018N* P=0.363N P=0.065N P=0.074N | |
|POLY 6 | P=0.020N* P=0.386N P=0.068N P=0.097N | |
|LOGISTIC REGRESSION| P=0.028N* P=0.391N P=0.071N P=0.105N | |
|COCH-ARM / FISHERS | P=0.019N* P=0.349N P=0.061N P=0.061N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Salivary Glands |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/46.78 4/44.87 2/45.85 0/40.35 |0/45.55 0/41.52 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 0.0% 8.9% 4.4% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/39 (0%) 2/33 (6%) 2/36 (6%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | --- 614 729 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.429N P=0.053 P=0.221 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.413N P=0.055 P=0.233 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.381N P=0.057 P=0.235 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.456N P=0.053 P=0.230 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.332N P=0.074 P=0.221 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.337N P=0.059 P=0.247 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 36
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Seminal Vesicle |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | |
|POLY-3 RATE (b) | 0/46.78 2/44.23 0/45.85 0/40.35 | |
|POLY-3 PERCENT (g) | 0.0% 4.5% 0.0% 0.0% | |
|TERMINAL (d) | 0/39 (0%) 1/33 (3%) 0/36 (0%) 0/27 (0%) | |
|FIRST INCIDENCE | --- 695 --- --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.471N P=0.208 (e) (e) | |
|POLY 3 | P=0.434N P=0.225 (e) (e) | |
|POLY 1.5 | P=0.423N P=0.230 (e) (e) | |
|POLY 6 | P=0.448N P=0.219 (e) (e) | |
|LOGISTIC REGRESSION| P=0.434N P=0.225 (e) (e) | |
|COCH-ARM / FISHERS | P=0.405N P=0.247 (e) (e) | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Skin |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/46.78 0/44.10 1/45.85 1/40.93 |1/45.55 2/43.01 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 2.1% 0.0% 2.2% 2.4% |2.2% 4.7% 0.0% 0.0% |
|TERMINAL (d) | 1/39 (3%) 0/33 (0%) 1/36 (3%) 0/27 (0%) |1/38 (3%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 729 (T) --- 729 (T) 545 |731 (T) 23 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.480 P=0.533N P=0.744 P=0.712 |P=0.205N P=0.472 P=0.547N P=0.534N |
|POLY 3 | P=0.506 P=0.512N P=0.756 P=0.730 |P=0.202N P=0.480 P=0.526N P=0.509N |
|POLY 1.5 | P=0.520 P=0.507N P=0.758 P=0.743 |P=0.195N P=0.487 P=0.517N P=0.503N |
|POLY 6 | P=0.487 P=0.517N P=0.754 P=0.713 |P=0.209N P=0.471 P=0.534N P=0.516N |
|LOGISTIC REGRESSION| P=0.588 (e) P=0.744 P=0.693N |P=0.222N P=0.604 (e) (e) |
|COCH-ARM / FISHERS | P=0.539 P=0.500N P=0.753N P=0.753N |P=0.188N P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 37
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/46.85 0/44.10 0/45.85 0/40.35 |0/45.55 1/42.01 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 4.3% 0.0% 0.0% 0.0% |0.0% 2.4% 0.0% 0.0% |
|TERMINAL (d) | 1/39 (3%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 710 --- --- --- |--- 584 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.143N P=0.270N P=0.257N P=0.329N |P=0.578N P=0.482 (e) (e) |
|POLY 3 | P=0.104N P=0.251N P=0.242N P=0.272N |P=0.586N P=0.484 (e) (e) |
|POLY 1.5 | P=0.108N P=0.245N P=0.240N P=0.257N |P=0.579N P=0.488 (e) (e) |
|POLY 6 | P=0.099N P=0.258N P=0.245N P=0.292N |P=0.594N P=0.478 (e) (e) |
|LOGISTIC REGRESSION| P=0.130N P=0.256N P=0.243N P=0.295N |P=0.584N P=0.524 (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |P=0.567N P=0.500 (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Skin: Prepuce |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 7/46.92 1/44.11 1/46.66 2/40.93 |0/45.55 0/41.52 0/39.96 0/43.48 |
|POLY-3 PERCENT (g) | 14.9% 2.3% 2.1% 4.9% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 5/39 (13%) 0/33 (0%) 0/36 (0%) 1/27 (4%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 0/32 (0%) |
|FIRST INCIDENCE | 698 728 422 545 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.116N P=0.058N P=0.045N* P=0.195N |(e) (e) (e) (e) |
|POLY 3 | P=0.063N P=0.037N* P=0.031N* P=0.116N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.062N P=0.034N* P=0.030N* P=0.100N |(e) (e) (e) (e) |
|POLY 6 | P=0.063N P=0.041N* P=0.031N* P=0.141N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.048N* P=0.045N* P=0.027N* P=0.107N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.064N P=0.030N* P=0.030N* P=0.080N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 38
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 13/50 (26%) 18/50 (36%) 10/50 (20%) |21/50 (42%) 12/48 (25%) 18/49 (37%) 11/50 (22%) |
|POLY-3 RATE (b) | 15/47.12 13/46.33 18/47.24 10/41.60 |21/47.23 12/43.03 18/41.92 11/45.24 |
|POLY-3 PERCENT (g) | 31.8% 28.1% 38.1% 24.0% |44.5% 27.9% 42.9% 24.3% |
|TERMINAL (d) | 12/39 (31%) 9/33 (27%) 11/36 (31%) 6/27 (22%) |14/38 (37%) 9/32 (28%) 12/30 (40%) 5/32 (16%) |
|FIRST INCIDENCE | 692 405 606 541 |505 522 416 542 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.534N P=0.582 P=0.271 P=0.533N |P=0.139N P=0.146N P=0.485 P=0.092N |
|POLY 3 | P=0.330N P=0.432N P=0.336 P=0.281N |P=0.056N P=0.076N P=0.527N P=0.032N* |
|POLY 1.5 | P=0.272N P=0.422N P=0.335 P=0.235N |P=0.049N* P=0.064N P=0.463N P=0.026N* |
|POLY 6 | P=0.404N P=0.447N P=0.340 P=0.347N |P=0.065N P=0.097N P=0.584N P=0.041N* |
|LOGISTIC REGRESSION| P=0.247N P=0.401N P=0.314 P=0.333N |P=0.054N P=0.063N P=0.460N P=0.028N* |
|COCH-ARM / FISHERS | P=0.197N P=0.412N P=0.335 P=0.178N |P=0.051N P=0.058N P=0.371N P=0.026N* |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Spleen |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 12/50 (24%) 15/50 (30%) 10/50 (20%) |17/50 (34%) 18/48 (38%) 15/49 (31%) 15/50 (30%) |
|POLY-3 RATE (b) | 9/46.78 12/44.16 15/45.85 10/40.35 |17/45.64 18/42.20 15/41.35 15/44.25 |
|POLY-3 PERCENT (g) | 19.2% 27.2% 32.7% 24.8% |37.3% 42.7% 36.3% 33.9% |
|TERMINAL (d) | 9/39 (23%) 11/33 (33%) 15/36 (42%) 10/27 (37%) |16/38 (42%) 15/32 (47%) 12/30 (40%) 11/32 (34%) |
|FIRST INCIDENCE | 729 (T) 715 729 (T) 729 (T) |709 635 416 565 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.144 P=0.173 P=0.071 P=0.172 |P=0.506N P=0.263 P=0.449 P=0.541 |
|POLY 3 | P=0.300 P=0.258 P=0.105 P=0.358 |P=0.333N P=0.382 P=0.551N P=0.455N |
|POLY 1.5 | P=0.371 P=0.280 P=0.111 P=0.417 |P=0.307N P=0.413 P=0.507N P=0.426N |
|POLY 6 | P=0.217 P=0.234 P=0.097 P=0.286 |P=0.359N P=0.347 P=0.584N P=0.487N |
|LOGISTIC REGRESSION| P=0.124 P=0.196 P=0.071 P=0.172 |P=0.374N P=0.283 P=0.580 P=0.536N |
|COCH-ARM / FISHERS | P=0.477 P=0.312 P=0.121 P=0.500 |P=0.300N P=0.440 P=0.442N P=0.415N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 39
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/46.78 0/44.10 0/45.85 0/40.35 |0/45.55 0/41.52 0/39.96 2/43.50 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 4.6% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 726 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.044 * (e) (e) P=0.209 |
|POLY 3 | (e) (e) (e) (e) |P=0.045 * (e) (e) P=0.227 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.046 * (e) (e) P=0.233 |
|POLY 6 | (e) (e) (e) (e) |P=0.044 * (e) (e) P=0.220 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.045 * (e) (e) P=0.214 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.046 * (e) (e) P=0.247 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/46.78 2/44.63 1/45.85 0/40.35 |0/45.55 0/41.52 1/39.96 1/43.48 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 2.2% 0.0% |0.0% 0.0% 2.5% 2.3% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 1/36 (3%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 1/30 (3%) 1/32 (3%) |
|FIRST INCIDENCE | --- 590 729 (T) --- |--- --- 731 (T) 731 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.534N P=0.221 P=0.484 (e) |P=0.215 (e) P=0.453 P=0.466 |
|POLY 3 | P=0.512N P=0.227 P=0.496 (e) |P=0.234 (e) P=0.474 P=0.491 |
|POLY 1.5 | P=0.491N P=0.231 P=0.498 (e) |P=0.239 (e) P=0.483 P=0.497 |
|POLY 6 | P=0.538N P=0.222 P=0.494 (e) |P=0.227 (e) P=0.466 P=0.484 |
|LOGISTIC REGRESSION| P=0.431N P=0.281 P=0.484 (e) |(e) (e) P=0.453 P=0.466 |
|COCH-ARM / FISHERS | P=0.461N P=0.247 P=0.500 (e) |P=0.236 (e) P=0.500 P=0.500 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 40
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 1/50 (2%) |1/50 (2%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 1/46.92 2/44.71 2/46.70 1/40.86 |1/45.74 1/42.29 2/40.84 1/43.77 |
|POLY-3 PERCENT (g) | 2.1% 4.5% 4.3% 2.5% |2.2% 2.4% 4.9% 2.3% |
|TERMINAL (d) | 0/39 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 1/30 (3%) 0/32 (0%) |
|FIRST INCIDENCE | 692 626 422 573 |681 446 353 653 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.594 P=0.464 P=0.489 P=0.699 |P=0.570 P=0.733 P=0.442 P=0.734 |
|POLY 3 | P=0.598 P=0.483 P=0.498 P=0.729 |P=0.579 P=0.743 P=0.461 P=0.751 |
|POLY 1.5 | P=0.585N P=0.490 P=0.500 P=0.742 |P=0.590 P=0.748 P=0.476 P=0.757 |
|POLY 6 | P=0.562 P=0.476 P=0.495 P=0.711 |P=0.568 P=0.736 P=0.448 P=0.744 |
|LOGISTIC REGRESSION| P=0.359N P=0.564 P=0.577 P=0.686N |P=0.560 P=0.734N P=0.535 P=0.762 |
|COCH-ARM / FISHERS | P=0.556N P=0.500 P=0.500 P=0.753N |P=0.591 P=0.753N P=0.500 P=0.753N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 10/50 (20%) 6/50 (12%) 4/50 (8%) |3/50 (6%) 1/50 (2%) 7/50 (14%) 1/50 (2%) |
|POLY-3 RATE (b) | 3/47.03 10/47.37 6/47.13 4/41.19 |3/45.74 1/42.29 7/42.97 1/43.77 |
|POLY-3 PERCENT (g) | 6.4% 21.1% 12.7% 9.7% |6.6% 2.4% 16.3% 2.3% |
|TERMINAL (d) | 1/39 (3%) 2/33 (6%) 3/36 (8%) 1/27 (4%) |2/38 (5%) 0/32 (0%) 2/30 (7%) 0/32 (0%) |
|FIRST INCIDENCE | 692 514 422 590 |681 446 318 653 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.517 P=0.033 * P=0.226 P=0.323 |P=0.460N P=0.361N P=0.109 P=0.361N |
|POLY 3 | P=0.540N P=0.036 * P=0.243 P=0.428 |P=0.429N P=0.334N P=0.132 P=0.321N |
|POLY 1.5 | P=0.494N P=0.035 * P=0.244 P=0.457 |P=0.415N P=0.326N P=0.142 P=0.311N |
|POLY 6 | P=0.508 P=0.036 * P=0.240 P=0.392 |P=0.445N P=0.346N P=0.125 P=0.333N |
|LOGISTIC REGRESSION| P=0.228N P=0.074 P=0.271 P=0.511 |P=0.450N P=0.290N P=0.195 P=0.307N |
|COCH-ARM / FISHERS | P=0.426N P=0.036 * P=0.243 P=0.500 |P=0.420N P=0.309N P=0.159 P=0.309N |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 41
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Testes |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 7/50 (14%) 1/50 (2%) 5/50 (10%) | |
|POLY-3 RATE (b) | 4/47.52 7/44.16 1/45.93 5/40.76 | |
|POLY-3 PERCENT (g) | 8.4% 15.9% 2.2% 12.3% | |
|TERMINAL (d) | 1/39 (3%) 6/33 (18%) 0/36 (0%) 3/27 (11%) | |
|FIRST INCIDENCE | 620 715 709 654 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.426 P=0.190 P=0.206N P=0.307 | |
|POLY 3 | P=0.542 P=0.220 P=0.189N P=0.405 | |
|POLY 1.5 | P=0.557N P=0.237 P=0.185N P=0.444 | |
|POLY 6 | P=0.502 P=0.200 P=0.196N P=0.356 | |
|LOGISTIC REGRESSION| P=0.544 P=0.238 P=0.164N P=0.472 | |
|COCH-ARM / FISHERS | P=0.517N P=0.262 P=0.181N P=0.500 | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/48 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/44.78 0/44.10 0/45.85 0/40.35 |0/45.55 0/41.52 0/39.85 2/43.65 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 4.6% |
|TERMINAL (d) | 0/37 (0%) 0/33 (0%) 0/36 (0%) 0/27 (0%) |0/38 (0%) 0/32 (0%) 0/30 (0%) 1/32 (3%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 687 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.046 * (e) (e) P=0.216 |
|POLY 3 | (e) (e) (e) (e) |P=0.046 * (e) (e) P=0.228 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.046 * (e) (e) P=0.234 |
|POLY 6 | (e) (e) (e) (e) |P=0.045 * (e) (e) P=0.221 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.047 * (e) (e) P=0.231 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.047 * (e) (e) P=0.247 |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 42
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Tooth |
| Malformation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/2 (100%) 1/1 (100%) 2/2 (100%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) |
|POLY-3 RATE (b) | 2/2.00 1/1.00 2/2.00 0/0.00 |0/0.00 0/0.00 0/0.00 1/1.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 100.0% 0.0% |0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 2/2 (100%) 1/1 (100%) 2/2 (100%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) --- |--- --- --- 726 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Uterus |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |5/50 (10%) 4/49 (8%) 1/49 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | |5/45.55 4/41.52 1/39.90 0/43.48 |
|POLY-3 PERCENT (g) | |11.0% 9.6% 2.5% 0.0% |
|TERMINAL (d) | |5/38 (13%) 4/32 (13%) 1/30 (3%) 0/32 (0%) |
|FIRST INCIDENCE | |731 (T) 731 (T) 731 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.017N* P=0.608N P=0.163N P=0.049N* |
|POLY 3 | |P=0.011N* P=0.558N P=0.135N P=0.034N* |
|POLY 1.5 | |P=0.010N* P=0.541N P=0.123N P=0.032N* |
|POLY 6 | |P=0.012N* P=0.579N P=0.145N P=0.037N* |
|LOGISTIC REGRESSION| |P=0.017N* P=0.608N P=0.163N (e) |
|COCH-ARM / FISHERS | |P=0.011N* P=0.513N P=0.107N P=0.028N* |
|=================================================================================================================================|
Date: 11/19/01 EXPERIMENT: 61427 TEST: 08 Page 43
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - VANADIUM PENTOXIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 1.0 2.0 4.0 |CONTROL 1.0 2.0 4.0 |
| | MG/M3 MG/M3 MG/M3 | MG/M3 MG/M3 MG/M3 |
|=================================================================================================================================|
| |
|Uterus |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |46/50 (92%) 43/49 (88%) 42/49 (86%) 41/50 (82%) |
|POLY-3 RATE (b) | |46/47.95 43/46.05 42/43.60 41/47.06 |
|POLY-3 PERCENT (g) | |95.9% 93.4% 96.3% 87.1% |
|TERMINAL (d) | |37/38 (97%) 31/32 (97%) 30/30 (100%) 30/32 (94%) |
|FIRST INCIDENCE | |505 446 490 255 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.454 P=0.245 P=0.157 P=0.453 |
|POLY 3 | |P=0.050N P=0.462N P=0.694 P=0.098N |
|POLY 1.5 | |P=0.028N* P=0.419N P=0.491N P=0.062N |
|POLY 6 | |P=0.120N P=0.543N P=0.509 P=0.192N |
|LOGISTIC REGRESSION| |P=0.054N P=0.489N P=0.623 P=0.099N |
|COCH-ARM / FISHERS | |P=0.091N P=0.357N P=0.251N P=0.117N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).