TDMS Study 88007-05 Pathology Tables
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
FINAL #1 CORE STUDY RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7632-00-0
Lock Date: 03/20/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 6 10 15
Natural Death 6 13 4 2
Survivors
Terminal Sacrifice 33 31 36 33
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (50) (50)
Inflammation 1 (2%)
Intestine Large, Colon (50) (48) (50) (50)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Inflammation, Granulomatous 1 (2%)
Parasite Metazoan 4 (8%) 1 (2%) 2 (4%) 7 (14%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 3 (6%) 5 (10%)
Basophilic Focus 45 (90%) 42 (84%) 48 (96%) 45 (90%)
Clear Cell Focus 9 (18%) 6 (12%) 8 (16%) 7 (14%)
Cyst 1 (2%)
Eosinophilic Focus 9 (18%) 10 (20%) 8 (16%) 10 (20%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 11 (22%) 7 (14%) 8 (16%)
Inflammation, Chronic Active 23 (46%) 23 (46%) 28 (56%) 28 (56%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mixed Cell Focus 11 (22%) 3 (6%) 7 (14%) 9 (18%)
Necrosis 5 (10%) 2 (4%) 4 (8%)
Pigmentation, Lipofuscin 1 (2%)
Regeneration 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 5 (10%) 4 (8%) 4 (8%)
Bile Duct, Hyperplasia 8 (16%) 4 (8%) 4 (8%) 4 (8%)
Mesentery (7) (5) (7) (4)
Fat, Inflammation, Chronic Active 6 (86%) 5 (100%) 7 (100%) 4 (100%)
Fat, Necrosis 1 (14%)
Pancreas (50) (50) (49) (50)
Atrophy 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 6 (12%) 6 (12%) 8 (16%) 8 (16%)
Acinus, Hyperplasia 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%) 2 (4%) 2 (4%)
Erosion 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperkeratosis 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Ulcer 4 (8%) 2 (4%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia 8 (16%) 6 (12%) 8 (16%) 40 (80%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Mineralization 2 (4%)
Heart (50) (49) (50) (50)
Inflammation, Chronic Active 3 (6%) 4 (8%) 3 (6%) 3 (6%)
Mineralization 2 (4%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 40 (80%) 39 (78%) 45 (90%) 45 (90%)
Degeneration 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 15 (30%) 11 (22%) 11 (22%) 10 (20%)
Hypertrophy 8 (16%) 7 (14%) 7 (14%) 4 (8%)
Necrosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 5 (10%) 1 (2%) 3 (6%)
Adrenal Medulla (50) (50) (45) (49)
Hyperplasia 6 (12%) 7 (14%) 4 (9%) 5 (10%)
Bilateral, Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Angiectasis 1 (2%)
Cyst 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Hemorrhage 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Cyst 4 (8%) 10 (20%) 5 (10%) 9 (18%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 10 (20%) 10 (20%) 19 (38%) 12 (24%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (50) (49) (48) (50)
Inflammation, Chronic Active 1 (2%)
Ultimobranchial Cyst 1 (2%) 1 (2%) 4 (8%)
Vacuolization Cytoplasmic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Bilateral, C-Cell, Hyperplasia 1 (2%)
C-Cell, Hyperplasia 24 (48%) 26 (53%) 34 (71%) 26 (52%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (48) (49) (49)
Atrophy 1 (2%)
Cyst 9 (20%) 1 (2%) 12 (24%) 3 (6%)
Hyperplasia 8 (17%) 4 (8%) 7 (14%) 7 (14%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Ovary (50) (49) (50) (50)
Cyst 4 (8%) 4 (8%) 3 (6%) 5 (10%)
Inflammation, Chronic Active 1 (2%)
Follicle, Cyst 1 (2%) 2 (4%) 2 (4%)
Periovarian Tissue, Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Uterus (50) (50) (50) (50)
Cyst 2 (4%)
Dysplasia 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Hydrometra 3 (6%) 4 (8%) 4 (8%) 5 (10%)
Inflammation, Chronic Active 1 (2%)
Thrombosis 2 (4%) 1 (2%)
Cervix, Hydrometra 1 (2%)
Cervix, Hyperplasia 1 (2%)
Cervix, Hypertrophy 1 (2%)
Cervix, Epithelium, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (2) (1) (2) (1)
Ectasia 1 (100%)
Lymph Node, Mandibular (49) (49) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Pigmentation, Lipofuscin 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50) (50) (50) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Lymphoid Follicle, Depletion Cellular 1 (2%)
Thymus (49) (47) (49) (48)
Atrophy 1 (2%) 1 (2%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 14 (28%) 10 (20%) 12 (24%) 10 (20%)
Hyperplasia 10 (20%) 5 (10%) 3 (6%) 9 (18%)
Skin (50) (50) (50) (50)
Ulcer 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosclerosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%) 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 2 (4%)
Inflammation, Chronic Active 16 (32%) 13 (26%) 14 (28%) 17 (34%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 10 (20%) 10 (20%) 8 (16%) 3 (6%)
Bronchiole, Epithelium, Hyperplasia 1 (2%) 1 (2%)
Nose (50) (49) (50) (50)
Inflammation, Chronic Active 3 (6%)
Olfactory Epithelium, Metaplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (3)
Inflammation, Chronic Active 1 (100%)
Cornea, Inflammation, Chronic Active 1 (33%)
Lens, Mineralization 1 (33%)
Retina, Degeneration 1 (100%) 3 (100%)
Harderian Gland (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Casts Protein 1 (2%)
Cyst 2 (4%) 4 (8%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 5 (10%) 4 (8%) 5 (10%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
Necrosis 1 (2%)
Nephropathy 14 (28%) 16 (32%) 20 (40%) 23 (46%)
Pigmentation 2 (4%) 3 (6%) 1 (2%)
Renal Tubule, Regeneration 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Inflammation, Chronic Active 3 (6%) 2 (4%) 2 (4%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 4 12 8
Natural Death 5 8 2 6
Survivors
Terminal Sacrifice 29 37 36 36
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 5 (10%) 4 (8%) 3 (6%) 2 (4%)
Intestine Large, Cecum (50) (50) (50) (49)
Congestion 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 3 (6%) 1 (2%)
Basophilic Focus 31 (62%) 34 (68%) 37 (74%) 42 (84%)
Clear Cell Focus 19 (38%) 25 (50%) 26 (52%) 23 (46%)
Cyst 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 5 (10%) 15 (30%) 12 (24%) 4 (8%)
Eosinophilic Focus 4 (8%) 10 (20%) 11 (22%) 6 (12%)
Fibrosis 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 11 (22%) 6 (12%) 4 (8%) 8 (16%)
Inflammation, Chronic Active 13 (26%) 19 (38%) 25 (50%) 24 (48%)
Mixed Cell Focus 7 (14%) 7 (14%) 4 (8%) 2 (4%)
Necrosis 5 (10%) 2 (4%) 1 (2%) 4 (8%)
Regeneration 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 8 (16%) 5 (10%) 4 (8%) 1 (2%)
Bile Duct, Hyperplasia 41 (82%) 38 (76%) 43 (86%) 38 (76%)
Mesentery (11) (7) (5) (8)
Fat, Inflammation, Chronic Active 8 (73%) 5 (71%) 5 (100%) 6 (75%)
Fat, Mineralization 1 (9%)
Fat, Necrosis 1 (20%)
Oral Mucosa (2) (1)
Pharyngeal, Cyst 1 (50%)
Pancreas (50) (50) (50) (49)
Atrophy 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 16 (32%) 27 (54%) 22 (44%) 28 (57%)
Acinus, Hyperplasia 4 (8%) 3 (6%) 6 (12%) 8 (16%)
Salivary Glands (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 1 (2%)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 2 (4%)
Hyperkeratosis 1 (2%) 4 (8%) 4 (8%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Ulcer 4 (8%) 1 (2%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia 12 (24%) 9 (18%) 10 (20%) 44 (88%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 (2%) 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Ulcer 2 (4%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tongue (1)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Inflammation, Chronic Active 9 (18%) 15 (30%) 16 (32%) 12 (24%)
Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 16 (32%) 21 (42%) 15 (30%) 22 (44%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 11 (22%) 15 (30%) 15 (30%) 10 (20%)
Hypertrophy 7 (14%) 7 (14%) 2 (4%) 9 (18%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 3 (6%) 8 (16%) 3 (6%)
Bilateral, Hyperplasia 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 11 (22%) 18 (36%) 16 (32%) 13 (26%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (49) (50) (50)
Angiectasis 1 (2%)
Cyst 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 9 (18%) 18 (36%) 10 (20%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 11 (22%) 17 (34%) 16 (32%) 13 (26%)
Follicle, Cyst 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Degeneration 1 (2%)
Preputial Gland (50) (50) (50) (50)
Cyst 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 8 (16%) 10 (20%) 6 (12%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Prostate (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Atrophy 34 (68%) 34 (68%) 36 (72%) 33 (67%)
Cyst 1 (2%)
Testes (50) (50) (50) (50)
Degeneration 8 (16%) 12 (24%) 11 (22%) 11 (22%)
Mineralization 7 (14%) 1 (2%) 2 (4%) 2 (4%)
Interstitial Cell, Hyperplasia 9 (18%) 6 (12%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%)
Myelofibrosis 1 (2%) 3 (6%)
Lymph Node (5) (4) (4) (2)
Ectasia 1 (25%)
Pancreatic, Ectasia 1 (20%)
Lymph Node, Mandibular (48) (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%) 1 (2%)
Ectasia 1 (2%)
Hyperplasia 1 (2%)
Pigmentation, Lipofuscin 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Congestion 2 (4%) 3 (6%)
Fibrosis 2 (4%) 2 (4%) 3 (6%) 4 (8%)
Hematopoietic Cell Proliferation 5 (10%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%) 1 (2%)
Capsule, Fibrosis 1 (2%)
Lymphoid Follicle, Depletion Cellular 1 (2%)
Thymus (50) (49) (49) (48)
Atrophy 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (47) (47) (47)
Cyst 1 (2%)
Galactocele 2 (4%) 1 (2%)
Hyperplasia 4 (9%) 6 (13%) 4 (9%) 3 (6%)
Skin (49) (50) (50) (50)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Epidermis, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 10/18/99
Route: DOSED WATER Time: 13:44:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 2 (4%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 18 (36%) 7 (14%) 11 (22%) 11 (22%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
Parasite Metazoan 1 (2%)
Alveolar Epithelium, Hyperplasia 11 (22%) 11 (22%) 20 (40%) 14 (28%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Bronchus, Inflammation, Suppurative 1 (2%)
Interstitium, Fibrosis 1 (2%) 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (2)
Hemorrhage 1 (100%)
Lens Capsule, Mineralization 1 (50%)
Retina, Degeneration 2 (100%)
Retrobulbar, Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Congestion 1 (2%)
Crystals 1 (2%)
Cyst 2 (4%) 4 (8%)
Infarct 1 (2%)
Mineralization 1 (2%) 1 (2%)
Nephropathy 42 (84%) 45 (90%) 47 (94%) 47 (94%)
Pigmentation 1 (2%) 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 6 (12%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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