TDMS Study 88007-06 Pathology Tables
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
2 YEAR CHRONIC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7632-00-0
Lock Date: 03/20/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 1 7 2 4
Natural Death 9 9 11 5
Survivors
Terminal Sacrifice 40 34 37 41
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 3 (6%) 1 (2%) 4 (8%)
Epithelium, Cytoplasmic Alteration 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Duodenum (50) (48) (50) (49)
Epithelium, Inflammation, Chronic Active 1 (2%)
Epithelium, Ulcer 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Necrosis 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (49) (49) (50) (50)
Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%)
Basophilic Focus 3 (6%) 4 (8%) 3 (6%) 1 (2%)
Clear Cell Focus 2 (4%) 3 (6%) 3 (6%) 2 (4%)
Congestion 1 (2%)
Eosinophilic Focus 7 (14%) 3 (6%) 4 (8%) 5 (10%)
Hematopoietic Cell Proliferation 2 (4%) 5 (10%) 3 (6%) 4 (8%)
Hemorrhage 1 (2%)
Infiltration Cellular, Mononuclear Cell 30 (60%) 32 (64%) 29 (58%) 35 (70%)
Inflammation, Chronic Active 36 (72%) 35 (70%) 30 (60%) 35 (70%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Mixed Cell Focus 3 (6%) 1 (2%)
Necrosis 5 (10%) 4 (8%) 3 (6%) 2 (4%)
Pigmentation 12 (24%) 17 (34%) 16 (32%) 18 (36%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 10 (20%) 17 (34%) 12 (24%) 13 (26%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Centrilobular, Necrosis 2 (4%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Hepatocyte, Centrilobular, Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (14) (19) (17) (13)
Congestion 1 (5%)
Hemorrhage 1 (6%)
Infiltration Cellular, Mononuclear Cell 1 (8%)
Inflammation, Chronic Active 1 (5%)
Inflammation, Granulomatous 1 (7%)
Pigmentation, Hemosiderin 1 (6%)
Thrombosis 1 (5%)
Artery, Inflammation, Chronic Active 1 (8%)
Fat, Necrosis 10 (71%) 7 (37%) 10 (59%) 11 (85%)
Oral Mucosa (1) (2) (3)
Gingival, Foreign Body 1 (100%) 2 (100%) 3 (100%)
Gingival, Inflammation, Chronic Active 1 (100%) 2 (100%) 2 (67%)
Pancreas (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 14 (28%) 10 (20%) 7 (14%) 13 (26%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Acinus, Hyperplasia 1 (2%)
Acinus, Hypertrophy 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Salivary Glands (49) (49) (48) (50)
Atrophy 2 (4%)
Infiltration Cellular, Mononuclear Cell 34 (69%) 36 (73%) 40 (83%) 35 (70%)
Stomach, Forestomach (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Ulcer 1 (2%) 2 (4%) 2 (4%)
Epithelium, Hyperkeratosis 1 (2%)
Epithelium, Hyperplasia 2 (4%) 3 (6%) 3 (6%) 6 (12%)
Epithelium, Inflammation, Chronic Active 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Mineralization 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Epithelium, Necrosis 1 (2%)
Glands, Ectasia 19 (38%) 16 (32%) 10 (20%) 21 (42%)
Glands, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Aorta, Inflammation, Chronic Active 1 (2%)
Aorta, Mineralization 2 (4%)
Pulmonary Artery, Mineralization 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (4%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Mineralization 1 (2%)
Valve, Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Degeneration, Fatty 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Capsule, Hyperplasia 49 (98%) 50 (100%) 49 (100%) 49 (98%)
Zona Fasciculata, Hyperplasia 1 (2%) 1 (2%)
Zona Fasciculata, Hypertrophy 1 (2%) 1 (2%)
Zona Glomerulosa, Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 45 (90%) 44 (88%) 40 (80%) 42 (84%)
Pigmentation 1 (2%)
Parathyroid Gland (33) (31) (31) (37)
Cyst 1 (3%)
Pituitary Gland (48) (47) (43) (48)
Pars Distalis, Angiectasis 1 (2%) 3 (6%) 3 (6%)
Pars Distalis, Cyst 2 (5%) 2 (4%)
Pars Distalis, Hyperplasia 2 (4%) 3 (6%) 4 (9%) 6 (13%)
Thyroid Gland (49) (49) (48) (49)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
Inflammation, Granulomatous 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (48)
Infiltration Cellular, Mononuclear Cell 7 (14%) 4 (8%) 13 (26%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 2 (4%) 2 (4%)
Duct, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (47) (49) (50) (49)
Angiectasis 1 (2%)
Cyst 6 (13%) 9 (18%) 9 (18%) 7 (14%)
Hemorrhage 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Adenomatous 1 (2%)
Mineralization 3 (6%) 1 (2%)
Pigmentation 1 (2%)
Thrombosis 2 (4%) 1 (2%) 1 (2%)
Uterus (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrometra 32 (64%) 31 (62%) 33 (66%) 37 (74%)
Infiltration Cellular, Mononuclear Cell 2 (4%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Endometrium, Hyperplasia, Cystic 13 (26%) 10 (20%) 16 (32%) 18 (36%)
Submucosa, Hyperplasia, Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 2 (4%)
Hyperplasia 1 (2%)
Myelofibrosis 2 (4%)
Myeloid Cell, Hyperplasia 2 (4%) 3 (6%) 1 (2%) 3 (6%)
Lymph Node (7) (7) (8) (4)
Inflammation, Granulomatous 1 (25%)
Inguinal, Hyperplasia, Lymphoid 1 (13%)
Lumbar, Hyperplasia, Lymphoid 1 (25%)
Mediastinal, Hematopoietic Cell Proliferation 1 (25%)
Mediastinal, Hyperplasia, Lymphoid 3 (38%) 1 (25%)
Mediastinal, Pigmentation, Hemosiderin 1 (14%)
Renal, Ectasia 1 (14%) 1 (13%)
Renal, Hemorrhage 1 (14%) 1 (13%)
Lymph Node, Mandibular (47) (46) (48) (48)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 5 (10%) 5 (10%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (49) (47) (49)
Ectasia 1 (2%) 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Granulomatous 1 (2%)
Spleen (49) (50) (50) (50)
Hematopoietic Cell Proliferation 37 (76%) 39 (78%) 35 (70%) 39 (78%)
Hyperplasia, Lymphoid 4 (8%) 3 (6%) 4 (8%) 1 (2%)
Metaplasia, Osseous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Capsule, Inflammation, Chronic Active 1 (2%)
Thymus (46) (47) (44) (46)
Cyst 10 (22%) 12 (26%) 17 (39%) 16 (35%)
Ectopic Parathyroid Gland 1 (2%) 5 (11%) 3 (7%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (49) (50)
Hyperplasia, Cystic 1 (2%) 3 (6%) 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 3 (6%) 2 (4%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosis 2 (4%)
Subcutaneous Tissue, Infiltration Cellular,
Mononuclear Cell 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Periosteum, Synovial Tissue, Inflammation,
Chronic Active 1 (2%)
Skeletal Muscle (3) (2) (1) (3)
Artery, Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Degeneration 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Peripheral Nerve (2)
Sciatic, Inflammation, Chronic Active 1 (50%)
Spinal Cord (2)
Demyelination 2 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%) 2 (4%)
Metaplasia, Osseous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mineralization 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 4 (8%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 2 (4%) 2 (4%)
Bronchus, Mineralization 1 (2%)
Interstitium, Inflammation, Chronic Active 1 (2%)
Vein, Mineralization 1 (2%) 1 (2%) 1 (2%)
Nose (50) (49) (50) (50)
Foreign Body 1 (2%)
Inflammation, Chronic Active 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Infarct 2 (4%) 4 (8%) 3 (6%) 6 (12%)
Infiltration Cellular, Mononuclear Cell 35 (70%) 37 (74%) 34 (68%) 40 (80%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 5 (10%) 8 (16%) 6 (12%) 4 (8%)
Nephropathy 20 (40%) 17 (34%) 13 (26%) 20 (40%)
Cortex, Cyst 1 (2%)
Vein, Inflammation, Chronic Active 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 25 (50%) 29 (58%) 24 (48%) 25 (50%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 3 2 3 1
Natural Death 8 3 5 10
Survivors
Terminal Sacrifice 39 45 42 39
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (50) (49) (49)
Cyst 1 (2%)
Intestine Small, Duodenum (49) (50) (48) (49)
Ectasia 2 (4%) 2 (4%)
Intestine Small, Jejunum (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Intussusception 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%)
Peyer's Patch, Inflammation, Granulomatous 1 (2%)
Intestine Small, Ileum (50) (49) (50) (50)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 3 (6%) 3 (6%) 1 (2%)
Clear Cell Focus 4 (8%) 6 (12%) 10 (20%) 7 (14%)
Eosinophilic Focus 12 (24%) 14 (28%) 14 (28%) 7 (14%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Infarct 2 (4%)
Infiltration Cellular, Mononuclear Cell 2 (4%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 25 (50%) 25 (50%) 31 (62%) 19 (38%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
Mixed Cell Focus 6 (12%) 2 (4%) 7 (14%) 9 (18%)
Necrosis 12 (24%) 4 (8%) 6 (12%) 2 (4%)
Pigmentation 2 (4%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 3 (6%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Hepatocyte, Karyomegaly 1 (2%)
Mesentery (7) (6) (7) (5)
Infiltration Cellular, Mononuclear Cell 2 (29%)
Inflammation, Granulomatous 2 (29%) 2 (29%)
Mineralization 1 (14%) 1 (17%)
Pigmentation 1 (17%) 1 (14%)
Artery, Inflammation, Chronic Active 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 4 (57%) 4 (67%) 3 (43%) 2 (40%)
Oral Mucosa (26) (27) (17) (19)
Gingival, Foreign Body 26 (100%) 27 (100%) 17 (100%) 19 (100%)
Gingival, Inflammation, Chronic Active 21 (81%) 22 (81%) 14 (82%) 11 (58%)
Pancreas (49) (50) (50) (50)
Fibrosis 1 (2%)
Infiltration Cellular, Mononuclear Cell 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Acinus, Hypertrophy 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Infiltration Cellular, Mononuclear Cell 27 (54%) 28 (56%) 33 (66%) 32 (64%)
Mineralization 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Ulcer 3 (6%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 6 (12%) 1 (2%) 2 (4%) 3 (6%)
Epithelium, Inflammation, Chronic Active 2 (4%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Mineralization 1 (2%)
Epithelium, Erosion 1 (2%)
Epithelium, Hyperplasia 2 (4%) 10 (20%)
Epithelium, Necrosis 1 (2%)
Glands, Ectasia 12 (24%) 18 (36%) 16 (32%) 14 (28%)
Tooth (5) (5) (4) (1)
Malformation 5 (100%) 4 (80%) 3 (75%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Inflammation, Chronic Active 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 3 (6%) 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%) 6 (12%) 4 (8%)
Degeneration, Fatty 1 (2%) 1 (2%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Capsule, Hyperplasia 46 (92%) 42 (84%) 40 (80%) 40 (80%)
Zona Fasciculata, Hyperplasia 1 (2%) 1 (2%)
Zona Fasciculata, Hypertrophy 18 (36%) 24 (48%) 14 (28%) 21 (42%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 46 (92%) 47 (94%) 49 (98%) 44 (88%)
Parathyroid Gland (36) (48) (38) (41)
Cyst 1 (3%)
Pituitary Gland (49) (49) (47) (47)
Pars Distalis, Cyst 3 (6%) 2 (4%) 2 (4%) 4 (9%)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Follicle, Cyst 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Inflammation, Chronic Active 1 (100%)
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 21 (42%) 22 (44%) 25 (50%) 25 (50%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
Preputial Gland (50) (50) (49) (50)
Atrophy 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 27 (54%) 28 (56%) 29 (59%) 25 (50%)
Inflammation, Chronic Active 7 (14%) 8 (16%) 4 (8%) 4 (8%)
Inflammation, Suppurative 2 (4%)
Duct, Cyst 33 (66%) 32 (64%) 33 (67%) 39 (78%)
Prostate (50) (50) (49) (50)
Infiltration Cellular, Mononuclear Cell 15 (30%) 22 (44%) 29 (59%) 28 (56%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
Seminal Vesicle (50) (50) (50) (50)
Congestion 1 (2%)
Dilatation 2 (4%) 2 (4%)
Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 2 (4%)
Inflammation, Suppurative 1 (2%)
Bilateral, Dilatation 1 (2%) 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Mineralization 2 (4%)
Germinal Epithelium, Atrophy 1 (2%) 1 (2%)
Germinal Epithelium, Necrosis 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Hemorrhage 1 (2%)
Thrombosis 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%) 2 (4%)
Lymph Node (1) (1) (3) (5)
Lumbar, Hyperplasia, Plasma Cell 1 (33%)
Mediastinal, Hemorrhage 1 (20%)
Mediastinal, Inflammation, Granulomatous 1 (20%)
Renal, Hyperplasia, Lymphoid 1 (100%)
Renal, Hyperplasia, Plasma Cell 1 (33%)
Lymph Node, Mandibular (47) (50) (47) (48)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (49) (48) (49)
Ectasia 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%)
Hyperplasia, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Eosinophil 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Spleen (50) (50) (50) (50)
Hematopoietic Cell Proliferation 22 (44%) 11 (22%) 14 (28%) 20 (40%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Thymus (37) (39) (38) (42)
Cyst 9 (24%) 14 (36%) 16 (42%) 9 (21%)
Hemorrhage 1 (3%)
Inflammation, Granulomatous 1 (3%)
Necrosis 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Ulcer 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Epidermis, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Infiltration Cellular,
Mononuclear Cell 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Cranium, Hyperostosis 1 (2%)
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NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Neuron, Necrosis 2 (4%)
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RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 4 (8%) 3 (6%)
Necrosis 2 (4%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) 6 (12%) 9 (18%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Interstitium, Inflammation, Chronic Active 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Mediastinum, Inflammation, Suppurative 1 (2%)
Mediastinum, Pigmentation 1 (2%)
Nose (50) (50) (49) (50)
Foreign Body 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
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a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:34:16
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B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
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SPECIAL SENSES SYSTEM
Eye (1)
Atrophy 1 (100%)
Harderian Gland (5) (4) (6) (1)
Hyperplasia 1 (25%)
Inflammation, Chronic 1 (25%)
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URINARY SYSTEM
Kidney (50) (50) (50) (50)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 11 (22%) 10 (20%) 9 (18%) 13 (26%)
Infiltration Cellular, Mononuclear Cell 42 (84%) 41 (82%) 41 (82%) 45 (90%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%)
Mineralization 48 (96%) 50 (100%) 48 (96%) 46 (92%)
Necrosis 1 (2%) 1 (2%)
Nephropathy 44 (88%) 49 (98%) 45 (90%) 42 (84%)
Pigmentation 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%) 1 (2%)
Cortex, Cyst 5 (10%) 9 (18%) 6 (12%) 4 (8%)
Renal Tubule, Hypertrophy, Focal 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Infiltration Cellular, Mononuclear Cell 6 (12%) 7 (14%) 16 (32%) 10 (20%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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