TDMS Study 88007-06 Pathology Tables
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
2 YEAR CHRONIC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7632-00-0
Lock Date: 03/20/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 1 7 2 4
Natural Death 9 9 11 5
Survivors
Terminal Sacrifice 40 34 37 41
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (48) (50) (50) (49)
Intestine Large, Rectum (49) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Intestine Small, Ileum (49) (49) (50) (50)
Leiomyosarcoma, Metastatic, Uterus 1 (2%)
Liver (50) (50) (50) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 2 (4%) 2 (4%) 4 (8%) 1 (2%)
Hepatocellular Adenoma 9 (18%) 6 (12%) 2 (4%) 5 (10%)
Hepatocellular Adenoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Hepatocholangiocarcinoma 1 (2%) 1 (2%)
Mesentery (14) (19) (17) (13)
Carcinoma, Metastatic, Islets, Pancreatic 1 (5%)
Fibrosarcoma, Metastatic, Skin 1 (5%) 1 (6%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (7%) 1 (5%)
Osteosarcoma, Metastatic, Bone 1 (6%)
Sarcoma 1 (6%)
Pancreas (50) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Salivary Glands (49) (49) (48) (50)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 2 (4%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 3 (6%)
Stomach, Glandular (50) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (50) (50) (48) (49)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 3 (6%)
Carcinoma 1 (2%)
Pituitary Gland (48) (47) (43) (48)
Pars Distalis, Adenoma 1 (2%) 3 (6%) 1 (2%)
Thyroid Gland (49) (49) (48) (49)
Bilateral, Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (48)
Ovary (47) (49) (50) (49)
Cystadenoma 2 (4%) 1 (2%) 3 (6%)
Granulosa Cell Tumor Benign 1 (2%)
Hemangioma 2 (4%) 1 (2%) 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Luteoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Teratoma Benign 1 (2%)
Uterus (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (7) (7) (8) (4)
Mediastinal, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (14%) 1 (14%)
Mediastinal, Sarcoma, Metastatic, Skin 1 (14%)
Lymph Node, Mandibular (47) (46) (48) (48)
Lymph Node, Mesenteric (50) (49) (47) (49)
Spleen (49) (50) (50) (50)
Hemangiosarcoma 1 (2%) 2 (4%)
Thymus (46) (47) (44) (46)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrosarcoma 5 (10%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (4%)
Subcutaneous Tissue, Pinna, Fibroma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Femur, Osteosarcoma 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (3) (2) (1) (3)
Carcinoma, Metastatic, Islets, Pancreatic 1 (50%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (33%)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Spinal Cord (2)
Meninges, Meningioma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 4 (8%) 2 (4%) 5 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 2 (4%) 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Fibrosarcoma, Metastatic, Skin 2 (4%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%) 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Schwannoma Malignant, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1) (2)
Adenoma 1 (100%) 2 (100%)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Lymphoma Malignant 7 (14%) 10 (20%) 8 (16%) 6 (12%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 21 32 31 32
Total Primary Neoplasms 25 49 36 41
Total Animals with Benign Neoplasms 13 22 14 20
Total Benign Neoplasms 13 25 14 24
Total Animals with Malignant Neoplasms 12 20 19 17
Total Malignant Neoplasms 12 24 22 17
Total Animals with Metastatic Neoplasms 3 6 4 3
Total Metastatic Neoplasm 11 15 13 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 3 2 3 1
Natural Death 8 3 5 10
Survivors
Terminal Sacrifice 39 45 42 39
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (49) (50) (48) (49)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Polyp Adenomatous 2 (4%) 4 (8%) 3 (6%)
Intestine Small, Jejunum (50) (50) (50) (50)
Carcinoma 5 (10%) 1 (2%) 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Cholangiocarcinoma 1 (2%)
Hemangiosarcoma 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Hemangiosarcoma, Metastatic, Spleen 2 (4%)
Hepatoblastoma 5 (10%) 1 (2%) 2 (4%)
Hepatocellular Carcinoma 9 (18%) 10 (20%) 6 (12%) 6 (12%)
Hepatocellular Carcinoma, Multiple 3 (6%)
Hepatocellular Adenoma 10 (20%) 15 (30%) 8 (16%) 13 (26%)
Hepatocellular Adenoma, Multiple 9 (18%) 2 (4%) 5 (10%) 5 (10%)
Sarcoma 1 (2%)
Mesentery (7) (6) (7) (5)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (20%)
Cholangiocarcinoma, Metastatic, Liver 1 (20%)
Hepatoblastoma, Metastatic, Liver 1 (14%)
Sarcoma, Metastatic, Liver 1 (14%)
Pancreas (49) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Sarcoma, Metastatic, Liver 1 (2%)
Tooth (5) (5) (4) (1)
Odontoma 2 (40%) 1 (25%)
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CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Fibrosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 3 (6%) 2 (4%) 2 (4%)
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Prostate (50) (50) (49) (50)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Seminal Vesicle (50) (50) (50) (50)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Testes (50) (50) (50) (50)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Interstitial Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Hemangiosarcoma 2 (4%)
Lymph Node (1) (1) (3) (5)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (20%)
Pancreatic, Cholangiocarcinoma, Metastatic,
Liver 1 (20%)
Renal, Cholangiocarcinoma, Metastatic, Liver 1 (20%)
Lymph Node, Mandibular (47) (50) (47) (48)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Lymph Node, Mesenteric (49) (49) (48) (49)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Spleen (50) (50) (50) (50)
Hemangiosarcoma 3 (6%) 2 (4%)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Thymus (37) (39) (38) (42)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma, Metastatic,
Brain 1 (2%)
Subcutaneous Tissue, Pinna, Melanoma
Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 10 (20%) 5 (10%) 8 (16%) 10 (20%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 4 (8%) 1 (2%) 3 (6%) 7 (14%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Fibrosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hepatoblastoma, Metastatic, Liver 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 2 (4%) 2 (4%) 2 (4%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma, Metastatic, Brain 1 (2%)
Sarcoma, Metastatic, Liver 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%) 2 (4%)
Mediastinum, Fibrosarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
Mediastinum, Hemangiosarcoma, Metastatic,
Bone Marrow 1 (2%)
Mediastinum, Sarcoma, Metastatic, Brain 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (5) (4) (6) (1)
Adenoma 4 (80%) 3 (75%) 4 (67%) 1 (100%)
Carcinoma 2 (33%)
Sarcoma, Metastatic, Brain 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (4%)
Renal Tubule, Adenoma 1 (2%)
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Lymphoma Malignant 1 (2%) 1 (2%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 88007-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99
Route: DOSED WATER Time: 09:40:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 0.075% 0.15% 0.30%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 35 36 38
Total Primary Neoplasms 72 55 55 52
Total Animals with Benign Neoplasms 28 28 26 29
Total Benign Neoplasms 39 37 32 31
Total Animals with Malignant Neoplasms 27 15 20 20
Total Malignant Neoplasms 33 18 23 21
Total Animals with Metastatic Neoplasms 13 4 7 7
Total Metastatic Neoplasm 18 7 11 24
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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