TDMS Study 88007-06 Pathology Tables
NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 2 YEAR CHRONIC MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 7632-00-0 Lock Date: 03/20/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2| | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Inflammation, Chronic | | Active | 3 | Epithelium, Ulcer | 4 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X | Clear Cell Focus | X | Eosinophilic Focus | X X X X X| Hematopoietic Cell Proliferation | 1 | Hemorrhage | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 1 3 1 1 1 1 1 1 1 1 2 1 1 1 1 1| Mineralization | | Mixed Cell Focus | X | Necrosis | 1 2 | Pigmentation | 2 1 1 1 1| Vacuolization Cytoplasmic | 1 4 2 | Bile Duct, Hyperplasia | | Hepatocyte, Centrilobular, | | Hypertrophy | | __________________________________________________________________________| Mesentery | + + + + + + + + +| Inflammation, Granulomatous | | Fat, Necrosis | 4 4 4 4 4 4| __________________________________________________________________________| Oral Mucosa | + | Gingival, Foreign Body | X | Gingival, Inflammation, Chronic | | Active | 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 1 1 1 1 1 | Acinus, Atrophy | 2 | Duct, Cyst | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2| | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3 | Epithelium, Hyperplasia | 3 2 | Epithelium, Inflammation, Chronic | | Active | 2 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Tongue | M | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 4 | Pulmonary Artery, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | Mineralization | 1 | Valve, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Hematopoietic Cell Proliferation | | Capsule, Hyperplasia | 2 1 2 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2| Zona Fasciculata, Hypertrophy | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | M + + M + M + + M + M + M + M + + + + + + + M M +| __________________________________________________________________________| Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2| | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 2 | Duct, Cyst | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 2 2 | Hemorrhage | 4 4 | Mineralization | 2 2 2 | Thrombosis | 3 4 | __________________________________________________________________________| Oviduct | + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 4 4 3 3 3 2 2 2 3 3 2 3 3 2 3 2| Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Suppurative | | Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 1 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + + + + + | Renal, Ectasia | | Renal, Hemorrhage | 4 | __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + M + + + + + + + + M + + + + + + +| Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + M + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 1 3 1 1 2 4 2 2 2 1 3 3 2 2 2 2 2 2| Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + M + + +| Cyst | 2 1 2 2 2 | Ectopic Parathyroid Gland | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Hyperplasia, Cystic | 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Ulcer | 4 | Subcutaneous Tissue, Fibrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2| | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 2 | Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Chronic Active | 1 1 | Bronchus, Mineralization | 2 | Vein, Mineralization | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Suppurative | 2 | Mineralization | 1 1 1 3 | Nephropathy | 1 1 1 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| | | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Inflammation, Chronic | | | Active | | 1 3.0| Epithelium, Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 3 | Clear Cell Focus | X | 2 | Eosinophilic Focus | X X | 7 | Hematopoietic Cell Proliferation | 2 | 2 1.5| Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 30 1.1| Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 1 1 2 1 1| 36 1.2| Mineralization | 1 | 1 1.0| Mixed Cell Focus | X X | 3 | Necrosis | 2 1 1 | 5 1.4| Pigmentation | 1 1 2 1 1 1 1 | 12 1.2| Vacuolization Cytoplasmic | 2 1 2 3 2 1 1 | 10 1.9| Bile Duct, Hyperplasia | 1 | 1 1.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + +| 14 | Inflammation, Granulomatous | 4 | 1 4.0| Fat, Necrosis | 4 4 3 4| 10 3.9| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Gingival, Foreign Body | | 1 | Gingival, Inflammation, Chronic | | | Active | | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| | | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Cell | 1 1 1 1 1 2 1 1 | 14 1.1| Acinus, Atrophy | | 1 2.0| Duct, Cyst | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 3.0| Epithelium, Hyperplasia | | 2 2.5| Epithelium, Inflammation, Chronic | | | Active | | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Glands, Ectasia | 1 1 1 1 1 1 1 1 1| 19 1.0| __________________________________________________________________________|____________| Tongue | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | 1 | 2 2.5| Pulmonary Artery, Mineralization | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| Mineralization | | 1 1.0| Valve, Inflammation, Chronic Active | 4 | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 2.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Capsule, Hyperplasia | 2 2 1 2 2 2 1 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2| 49 1.8| Zona Fasciculata, Hypertrophy | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2| 45 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M M M + + M + + + M + + M + + + M + + + M + + + +| 33 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Pars Distalis, Angiectasis | 2 | 1 2.0| Pars Distalis, Hyperplasia | 2 1 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| | | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1| 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 7 1.1| Inflammation, Chronic Active | | 1 2.0| Duct, Cyst | | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + M + + + M + + + + M + + + + + + + + + + +| 47 | Cyst | 2 2 2 | 6 2.3| Hemorrhage | | 2 4.0| Mineralization | | 3 2.0| Thrombosis | | 2 3.5| __________________________________________________________________________|____________| Oviduct | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 2 3 4 4 2 2 2 3 3 3 4 4 2 2 2 | 32 2.8| Infiltration Cellular, Mononuclear | | | Cell | 2 1| 2 1.5| Inflammation, Suppurative | 3 | 1 3.0| Endometrium, Hyperplasia, Cystic | 2 2 2 2 | 13 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 3 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 7 | Renal, Ectasia | 3 | 1 3.0| Renal, Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 1 2 3 2 3 1 2 3 2 2 2 2 1 2 2 | 37 2.1| Hyperplasia, Lymphoid | 3 3 3 3 | 4 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + + + + + + + + M + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| | | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Cyst | 2 1 1 1 1 | 10 1.5| Ectopic Parathyroid Gland | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Cystic | | 1 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| Ulcer | | 1 4.0| Subcutaneous Tissue, Fibrosis | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration | | 1 2.0| Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 2 | 1 2.0| Inflammation, Chronic Active | | 2 1.0| Bronchus, Mineralization | | 1 2.0| Vein, Mineralization | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 | 2 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3| | | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Mineralization | 1 | 5 1.4| Nephropathy | 1 1 1 1 3 1 3 1 1 1 1 1 1 1| 20 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 2 1 1 1 1 1 2 2 1| 25 1.1| Inflammation, Chronic Active | | 1 2.0| Mineralization | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6| | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 | Epithelium, Cytoplasmic Alteration | 3 | Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + M + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X | Eosinophilic Focus | X X X | Hematopoietic Cell Proliferation | 1 2 1 1| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 2 1 1 1 1 2| Inflammation, Chronic Active | 1 2 1 1 3 1 1 1 1 1 2 1 1 1 1 1 1 | Mineralization | | Mixed Cell Focus | X | Necrosis | 2 1 | Pigmentation | 1 1 2 1 1 | Thrombosis | | Vacuolization Cytoplasmic | 2 1 2 1 1 2 4 2 2 1 2 1| Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + + + + + + +| Congestion | 1| Inflammation, Chronic Active | 2 | Thrombosis | 4 | Fat, Necrosis | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 | Inflammation, Chronic Active | 1 | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6| | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Ulcer | 2 2 | Epithelium, Hyperplasia | 2 2 | Epithelium, Inflammation, Chronic | | Active | 2 2 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Ectasia | 1 1 1 1 1 1 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 | Inflammation, Chronic Active | 2 | Mineralization | 1 1 | Artery, Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | Hematopoietic Cell Proliferation | 1 1 | Inflammation, Chronic Active | 2 | Capsule, Hyperplasia | 2 2 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2| Zona Fasciculata, Hypertrophy | | Zona Glomerulosa, Hyperplasia | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + + M + + + M + + + M + M M M + + + + M M + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 3 | Pars Distalis, Hyperplasia | 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Inflammation, Suppurative | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6| | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Hemorrhage | | Hyperplasia, Adenomatous | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrometra | 2 4 2 2 3 2 4 2 4 2 2 4 4 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 3 4 | __________________________________________________________________________| Lymph Node | + + + | Mediastinal, Pigmentation, | | Hemosiderin | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + M + + M +| Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 1 1 1 3 1 2 1 1 1 3 2 2 3 2 2 3 2 2| Hyperplasia, Lymphoid | 3 4 2 | Metaplasia, Osseous | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 2 1 1| Ectopic Parathyroid Gland | 1 2 1 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 | Ulcer | 4 | Epidermis, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6| DAY ON TEST | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6| | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Infiltration Cellular, Mononuclear | | Cell | 2 2 | Inflammation, Chronic Active | 3 1 1 | Mineralization | 1 | Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 3 1 2 | Vein, Mineralization | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + M +| Nasolacrimal Duct, Inflammation, | | Suppurative | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | 2 | Infarct | 2 2 4 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | 1 1 | Nephropathy | 1 1 1 1 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2| | | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 1.0| Infiltration Cellular, Mononuclear | | | Cell | 1| 3 1.0| Epithelium, Cytoplasmic Alteration | | 1 3.0| Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + I + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X| 4 | Clear Cell Focus | X | 3 | Eosinophilic Focus | | 3 | Hematopoietic Cell Proliferation | 1 | 5 1.2| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 1 1 1| 32 1.2| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 2 1| 35 1.2| Mineralization | 1 | 1 1.0| Mixed Cell Focus | | 1 | Necrosis | 4 2 | 4 2.3| Pigmentation | 2 1 1 1 1 2 2 2 1 1 1 1| 17 1.3| Thrombosis | 3 | 1 3.0| Vacuolization Cytoplasmic | 2 2 1 2 1 | 17 1.7| Bile Duct, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + +| 19 | Congestion | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| Thrombosis | | 1 4.0| Fat, Necrosis | 4 4 4 4 4 4| 7 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 2 1 1| 10 1.1| Inflammation, Chronic Active | | 1 1.0| Duct, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2| | | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2| 36 1.1| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| Ulcer | | 2 2.0| Epithelium, Hyperplasia | 2 | 3 2.0| Epithelium, Inflammation, Chronic | | | Active | | 3 1.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glands, Ectasia | 1 1 1 1 1 1 1 1 | 16 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| Mineralization | | 2 1.0| Artery, Mineralization | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 | 2 1.5| Hematopoietic Cell Proliferation | | 2 1.0| Inflammation, Chronic Active | | 1 2.0| Capsule, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 1.9| Zona Fasciculata, Hypertrophy | 2 | 1 2.0| Zona Glomerulosa, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 44 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + M M + + + + + + M + M + M M M + + M + + + + +| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + I + M + + + + + + + + + + + + + + + + +| 47 | Pars Distalis, Angiectasis | 3 | 3 2.7| Pars Distalis, Hyperplasia | 2 | 3 2.3| __________________________________________________________________________|____________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| Follicle, Cyst | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2| | | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 | 4 1.0| Inflammation, Suppurative | 1 1 | 2 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Cyst | 2 2 4 4 3 2 | 9 2.6| Hemorrhage | 4 | 1 4.0| Hyperplasia, Adenomatous | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| Hydrometra | 2 2 3 2 3 4 4 4 2 3 3 3 3 2 2 2 3 2 | 31 2.8| Endometrium, Hyperplasia, Cystic | 2 3 2 2 2| 10 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 4 | 3 3.7| __________________________________________________________________________|____________| Lymph Node | + + + + | 7 | Mediastinal, Pigmentation, | | | Hemosiderin | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia, Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Ectasia | 3 | 1 3.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 1 1 1 1 2 2 1 1 2 4 1 1 2 2 1 2 1 2 | 39 1.7| Hyperplasia, Lymphoid | | 3 3.0| Metaplasia, Osseous | 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + + + M M + + + + +| 47 | Cyst | 1 1 2 2 1 2 1 1 | 12 1.3| Ectopic Parathyroid Gland | 1 | 5 1.2| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | 2 | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2| | | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 3 2.0| Ulcer | | 1 4.0| Epidermis, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 2 2.0| Inflammation, Chronic Active | | 3 1.7| Mineralization | | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 3 2.0| Vein, Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nasolacrimal Duct, Inflammation, | | | Suppurative | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | | 1 2.0| Infarct | | 4 2.3| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 2| 37 1.1| Mineralization | 1 1 1 1 1 1| 8 1.0| Nephropathy | 1 1 1 1 2 1 1 2 1 1 | 17 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2| | | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 2 1 1 1 1 1 1 1 1 1 2| 29 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3| | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 2 1 1 1| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 2 1| Mineralization | 2 | Necrosis | 2 1 3 | Pigmentation | 1 1 1 2 1| Vacuolization Cytoplasmic | 4 3 1 2 4 3 2 2 1 | Bile Duct, Cyst | 3 | __________________________________________________________________________| Mesentery | + + + + + + + + | Hemorrhage | | Pigmentation, Hemosiderin | | Fat, Necrosis | 4 4 4 4 4 | __________________________________________________________________________| Oral Mucosa | | Gingival, Foreign Body | | Gingival, Inflammation, Chronic | | Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 | Acinus, Hyperplasia | 1 | Artery, Inflammation, Chronic Active | 1 | __________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 2 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 1 2 | Epithelium, Hyperplasia | 2 2 | Epithelium, Inflammation, Chronic | | Active | 1 1 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3| | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 | Epithelium, Necrosis | 1 | Glands, Ectasia | 1 1 1 1 1 1| Glands, Necrosis | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Degeneration, Fatty | 2 | Capsule, Hyperplasia | 2 2 1 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Zona Fasciculata, Hyperplasia | | __________________________________________________________________________| Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2| Pigmentation | 2 | __________________________________________________________________________| Parathyroid Gland | M + M M + + + + + M + + + + + + + M + M + + + M M| Cyst | | __________________________________________________________________________| Pituitary Gland | + + M M + + + + I I + + + + + + + + I + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 1 1 | __________________________________________________________________________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 2 1 1 1 | Inflammation, Suppurative | 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 4 2 | Hemorrhage | 4 | Thrombosis | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3| | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 4 2 4 4 2 4 3 2 2 3 3 4| Inflammation, Suppurative | | Endometrium, Hyperplasia, Cystic | 1 2 2 1 2 1 | Submucosa, Hyperplasia, Stromal | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | 1 | Myeloid Cell, Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | + + + + + + | Inguinal, Hyperplasia, Lymphoid | 2 | Mediastinal, Hyperplasia, Lymphoid | 3 2 | Renal, Ectasia | | Renal, Hemorrhage | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 3 3 2| Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + M + M + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Fibrosis | | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 2 2 4 3 3 3 1 1 3 2 1 2 1 3 2| Hyperplasia, Lymphoid | 3 3 | __________________________________________________________________________| Thymus | + + + + + M + + + M M + + + + + M + + M + + + M +| Cyst | 2 1 2 1 1 | Ectopic Parathyroid Gland | | Hyperplasia, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 | Ulcer | 4 | Epidermis, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3| | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Larynx | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | 2 | Mineralization | | Alveolar Epithelium, Hyperplasia | 1 2 1 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 | Vein, Mineralization | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Inflammation, Chronic Active | | Nasolacrimal Duct, Inflammation, | | Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Mineralization | 1 1 1 1 | Nephropathy | 1 1 1 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 2 1 1 1 1 1 1 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2| | | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X| 3 | Clear Cell Focus | X X | 3 | Eosinophilic Focus | X X | 4 | Hematopoietic Cell Proliferation | 1 1 | 3 1.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0| Mineralization | | 1 2.0| Necrosis | | 3 2.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1| 16 1.1| Vacuolization Cytoplasmic | 1 1 1 | 12 2.1| Bile Duct, Cyst | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 17 | Hemorrhage | 3 | 1 3.0| Pigmentation, Hemosiderin | 1 | 1 1.0| Fat, Necrosis | 4 2 4 4 4 | 10 3.8| __________________________________________________________________________|____________| Oral Mucosa | + + | 2 | Gingival, Foreign Body | X X | 2 | Gingival, Inflammation, Chronic | | | Active | 1 2 | 2 1.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 7 1.0| Acinus, Hyperplasia | | 1 1.0| Artery, Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1| 40 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2| | | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 2 1.5| Epithelium, Hyperplasia | 2 | 3 2.0| Epithelium, Inflammation, Chronic | | | Active | | 3 1.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | | 1 2.0| Epithelium, Necrosis | | 1 1.0| Glands, Ectasia | 1 1 1 1| 10 1.0| Glands, Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Tongue | M | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Accessory Adrenal Cortical Nodule | | 1 2.0| Degeneration, Fatty | | 1 2.0| Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2| 49 1.9| Zona Fasciculata, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 40 2.1| Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M M + + M M M I + M + + M + M + + M + M + + +| 31 | Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + M + +| 43 | Pars Distalis, Cyst | 1 1 | 2 1.0| Pars Distalis, Hyperplasia | 2 1| 4 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2| | | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 | 13 1.1| Inflammation, Suppurative | | 2 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 2 2 | 9 2.2| Hemorrhage | | 1 4.0| Thrombosis | | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 4 4 3 3 2 4 4 2 4 3 4 4 2 4 4 4 4 2 3 3 4 | 33 3.3| Inflammation, Suppurative | 2 2 | 2 2.0| Endometrium, Hyperplasia, Cystic | 3 2 2 2 1 2 2 2 2 3| 16 1.9| Submucosa, Hyperplasia, Stromal | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myelofibrosis | 1 | 2 1.0| Myeloid Cell, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 8 | Inguinal, Hyperplasia, Lymphoid | | 1 2.0| Mediastinal, Hyperplasia, Lymphoid | 3 | 3 2.7| Renal, Ectasia | 4 | 1 4.0| Renal, Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Hyperplasia, Lymphoid | 3 3| 5 2.8| Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | Ectasia | 4 4 | 2 4.0| Fibrosis | 2 | 1 2.0| Hyperplasia, Lymphoid | 3 | 2 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 1 1 1 1 3 1 1 2 2 1 1 3 2 1 2 4 3 | 35 1.9| Hyperplasia, Lymphoid | 4 4 | 4 3.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | Cyst | 1 2 2 1 2 1 2 1 2 1 1 1 | 17 1.4| Ectopic Parathyroid Gland | 1 1 1 | 3 1.0| Hyperplasia, Lymphoid | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2| | | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 3.0| Ulcer | | 1 4.0| Epidermis, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | M | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 1 | 2 1.5| Mineralization | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | | 4 1.3| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 | 2 3.0| Vein, Mineralization | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 3 | 1 3.0| Inflammation, Chronic Active | 3 | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cataract | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 1 | 3 1.7| Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2| | | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cell | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.1| Mineralization | 1 1 | 6 1.0| Nephropathy | 1 1 2 1 1 1 1 2 1 | 13 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3| | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 | Basophilic Focus | X | Clear Cell Focus | X | Congestion | 2 | Eosinophilic Focus | X X X | Hematopoietic Cell Proliferation | 1 1 2 1 | Infiltration Cellular, Mononuclear | | Cell | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1| Necrosis | 2 | Pigmentation | 1 1 1 1 1 1 1 1 1 | Vacuolization Cytoplasmic | 1 2 4 3 1 2 2 | Bile Duct, Hyperplasia | 1| Centrilobular, Necrosis | | Centrilobular, Vacuolization | | Cytoplasmic | | __________________________________________________________________________| Mesentery | + + + + + + + | Infiltration Cellular, Mononuclear | | Cell | | Artery, Inflammation, Chronic Active | 2 | Fat, Necrosis | 4 4 4 4 4 | __________________________________________________________________________| Oral Mucosa | + + + | Gingival, Foreign Body | X X X | Gingival, Inflammation, Chronic | | Active | 1 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 2 1 1 1 1 | Acinus, Atrophy | 3 | Acinus, Hypertrophy | | Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3| | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 | Infiltration Cellular, Mononuclear | | Cell | 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperkeratosis | | Epithelium, Hyperplasia | 2 3 3 | Epithelium, Inflammation, Chronic | | Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 | Glands, Ectasia | 2 1 1 1 2 1 1 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Inflammation, Chronic Active | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 | Degeneration, Fatty | 1 2 | Hematopoietic Cell Proliferation | | Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Zona Fasciculata, Hyperplasia | | Zona Glomerulosa, Hyperplasia | 1 | __________________________________________________________________________| Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + M + M + + + + + M + + + + M + M + M + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 1 2 2 | Pars Distalis, Cyst | 1 1| Pars Distalis, Hyperplasia | 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Inflammation, Granulomatous | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3| | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 3 4 | Hemorrhage | 4 | Mineralization | | Pigmentation | | Thrombosis | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 4 3 2 2 2 3 4 2 4 4 3 2 2 2 2 3 3| Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hyperplasia | 3 | Myeloid Cell, Hyperplasia | 4 4 | __________________________________________________________________________| Lymph Node | + + + | Inflammation, Granulomatous | | Lumbar, Hyperplasia, Lymphoid | 3 | Mediastinal, Hematopoietic Cell | | Proliferation | 1 | Mediastinal, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 | Hyperplasia, Lymphoid | 3 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Inflammation, Granulomatous | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 2 2 1 2 3 3 2 2 2 3 2 2 2 2 1| Hyperplasia, Lymphoid | 3 | Capsule, Inflammation, Chronic Active| 3 | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + M + + + + + M + + +| Cyst | 1 2 2 1 2 1 2| Ectopic Parathyroid Gland | 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3| | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Infiltration | | Cellular, Mononuclear Cell | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Periosteum, Synovial Tissue, | | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Skeletal Muscle | | Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Inflammation, Chronic Active| | __________________________________________________________________________| Spinal Cord | | Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 | Metaplasia, Osseous | | Alveolar Epithelium, Hyperplasia | 1 3 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 | Interstitium, Inflammation, Chronic | | Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Nasolacrimal Duct, Inflammation, | | Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 1 3 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Infiltration Cellular, Plasma Cell | 1 | Mineralization | 1 1 | Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3| | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cortex, Cyst | | Vein, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 2 1 1| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0| | | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 4 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Hyperplasia, Lymphoid | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 2.0| Basophilic Focus | | 1 | Clear Cell Focus | X | 2 | Congestion | | 1 2.0| Eosinophilic Focus | X X | 5 | Hematopoietic Cell Proliferation | | 4 1.3| Infiltration Cellular, Mononuclear | | | Cell | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | 35 1.1| Inflammation, Chronic Active | 1 1 1 3 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 | 35 1.1| Necrosis | 2 | 2 2.0| Pigmentation | 1 2 1 1 1 1 1 1 2| 18 1.1| Vacuolization Cytoplasmic | 1 1 1 2 3 2| 13 1.9| Bile Duct, Hyperplasia | | 1 1.0| Centrilobular, Necrosis | 2 3| 2 2.5| Centrilobular, Vacuolization | | | Cytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + +| 13 | Infiltration Cellular, Mononuclear | | | Cell | 2| 1 2.0| Artery, Inflammation, Chronic Active | | 1 2.0| Fat, Necrosis | 4 4 4 4 4 4| 11 4.0| __________________________________________________________________________|____________| Oral Mucosa | | 3 | Gingival, Foreign Body | | 3 | Gingival, Inflammation, Chronic | | | Active | | 2 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0| | | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 1 | 13 1.2| Acinus, Atrophy | | 1 3.0| Acinus, Hypertrophy | 2 | 1 2.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 2 2.5| Infiltration Cellular, Mononuclear | | | Cell | 2 2 1 1 2 2 1 2 1 1 1 1 1 2 2 1 1| 35 1.3| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperkeratosis | 3 | 1 3.0| Epithelium, Hyperplasia | 3 2 2 | 6 2.5| Epithelium, Inflammation, Chronic | | | Active | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | | 1 2.0| Glands, Ectasia | 1 2 1 1 1 1 1 2 2 1 1 1 | 21 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Artery, Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 1.0| Degeneration, Fatty | | 2 1.5| Hematopoietic Cell Proliferation | 1 1 | 2 1.0| Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1| 49 2.0| Zona Fasciculata, Hyperplasia | 1 | 1 1.0| Zona Glomerulosa, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 42 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M M + M + + + + + + + + + + M + M + + + + + +| 37 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis | | 3 1.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0| | | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Cyst | | 2 1.0| Pars Distalis, Hyperplasia | 1 2 1 | 6 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 | 1 2.0| Follicle, Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | Inflammation, Granulomatous | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 3 1.0| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| Cyst | 2 1 3 2 4 | 7 2.7| Hemorrhage | | 1 4.0| Mineralization | 3 | 1 3.0| Pigmentation | 3 | 1 3.0| Thrombosis | 4 | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 3 3 2 2 2 4 4 2 2 2 3 2 4 4 4 2 3 3 2| 37 2.8| Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 1 2 2 | 18 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2| 2 2.0| Hyperplasia | | 1 3.0| Myeloid Cell, Hyperplasia | 4 | 3 4.0| __________________________________________________________________________|____________| Lymph Node | + | 4 | Inflammation, Granulomatous | 4 | 1 4.0| Lumbar, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Hematopoietic Cell | | | Proliferation | | 1 1.0| Mediastinal, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0| | | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia, Lymphoid | 2 3 | 5 2.8| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | | 1 2.0| Inflammation, Granulomatous | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 1 2 2 2 1 3 2 2 2 2 1 2 4 1 1 2 1 2 4| 39 2.0| Hyperplasia, Lymphoid | | 1 3.0| Capsule, Inflammation, Chronic Active| | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| 46 | Cyst | 1 1 1 1 1 2 2 2 2 | 16 1.5| Ectopic Parathyroid Gland | 2 | 2 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Infiltration | | | Cellular, Mononuclear Cell | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Periosteum, Synovial Tissue, | | | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | + + + | 3 | Artery, Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | + + | 2 | Sciatic, Inflammation, Chronic Active| 2 | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | + + | 2 | Demyelination | 3 3 | 2 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 1 2.0| Metaplasia, Osseous | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0| | | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.5| Interstitium, Inflammation, Chronic | | | Active | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nasolacrimal Duct, Inflammation, | | | Suppurative | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 1 2 2 | 6 1.8| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 3 1 3 1 1| 40 1.2| Infiltration Cellular, Plasma Cell | | 1 1.0| Mineralization | 1 1| 4 1.0| Nephropathy | 1 1 1 1 1 1 | 20 1.1| Cortex, Cyst | 2 | 1 2.0| Vein, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 | 25 1.1| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X| Eosinophilic Focus | X X X X X | Fibrosis | | Infarct | 4 | Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 1 1| Mineralization | | Mixed Cell Focus | X X X X| Necrosis | 2 2 1 1 4 2 1 | Pigmentation | | Vacuolization Cytoplasmic | 1 2| Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + | Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Granulomatous | | Mineralization | | Fat, Necrosis | 4 | __________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + | Gingival, Foreign Body | X X X X X X X X X X X | Gingival, Inflammation, Chronic | | Active | 2 2 1 2 1 1 1 2 1 1 2 | __________________________________________________________________________| Pancreas | + + + + + + + I + + + + + + + + + + + + + + + + +| Fibrosis | | Infiltration Cellular, Mononuclear | | Cell | 1 1 | Inflammation, Chronic Active | | Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 1 1 4 | Epithelium, Hyperplasia | 1 2 2 2 | Epithelium, Inflammation, Chronic | | Active | 1 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Ectasia | 1 1 1 1 1 1 1 2| __________________________________________________________________________| Tooth | + + | Malformation | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 | Atrium, Thrombosis | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Degeneration, Fatty | | Capsule, Hyperplasia | 2 1 1 2 3 1 1 1 1 1 1 2 2 1 1 1 2 4 1 1 1 2| Zona Fasciculata, Hypertrophy | 2 2 2 1 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 2 1 2 2 2 2 2 2 1 3 2 3 2 1 2 2 2 2| __________________________________________________________________________| Parathyroid Gland | M M M M M M M + + + M M + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Infiltration Cellular, Mononuclear | | Cell | 2 2 1 1 2 2 1 2 1 2 2 2 1 2| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 3 1 | Duct, Cyst | 3 2 2 2 2 2 2 2 2 2 4 2 2 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 | Inflammation, Chronic Active | | Inflammation, Suppurative | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Inflammation, Chronic Active | 3 | Bilateral, Dilatation | 4| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + M + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphocyte | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 4 2 2 2 4 2 2 3 2 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | M M M + + M + + + + + M + + + + M M + + + + M M +| Cyst | 2 2 2 1 2 1 | Hemorrhage | 4 | Inflammation, Granulomatous | | Necrosis | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation, Chronic Active | 2 | Ulcer | 4 | Epidermis, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Neuron, Necrosis | 2 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2| | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation, Chronic Active | | Mineralization | 1 1 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 3 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 | Inflammation, Chronic Active | | Inflammation, Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 2 2 2| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | | Inflammation, Suppurative | 2 | Metaplasia, Osseous | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | 2 | Nephropathy | 2 1 2 1 1 1 2 1 1 1 1 1 2 1 1 2 1 2 2 1| Pigmentation | | Cortex, Cyst | 2 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 3 | Clear Cell Focus | X | 4 | Eosinophilic Focus | X X X X X X X| 12 | Fibrosis | 3 | 1 3.0| Infarct | 4 | 2 4.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 2 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 25 1.1| Mineralization | 3 | 1 3.0| Mixed Cell Focus | X X | 6 | Necrosis | 3 2 2 1 2 | 12 1.9| Pigmentation | 3 2 | 2 2.5| Vacuolization Cytoplasmic | 3 | 3 2.0| Bile Duct, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + + + + | 7 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 2 1.0| Inflammation, Granulomatous | 3 2 | 2 2.5| Mineralization | 1 | 1 1.0| Fat, Necrosis | 4 4 4 | 4 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + | 26 | Gingival, Foreign Body | X X X X X X X X X X X X X X X | 26 | Gingival, Inflammation, Chronic | | | Active | 1 1 1 2 2 1 1 1 3 2 | 21 1.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 4 | 1 4.0| Infiltration Cellular, Mononuclear | | | Cell | | 2 1.0| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Acinus, Atrophy | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2| 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 3 2.0| Epithelium, Hyperplasia | 3 2 | 6 2.0| Epithelium, Inflammation, Chronic | | | Active | | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glands, Ectasia | 1 1 1 2 | 12 1.2| __________________________________________________________________________|____________| Tooth | + + + | 5 | Malformation | X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 3 1.0| Atrium, Thrombosis | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1| 2 1.5| Degeneration, Fatty | 1| 1 1.0| Capsule, Hyperplasia | 2 1 3 1 1 1 1 1 1 1 3 2 2 1 1 1 2 1 1 2 1 1 1 2| 46 1.5| Zona Fasciculata, Hypertrophy | 2 1 1 2 2 1 1 1 1 1 2| 18 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 3 2 2 2 2 2 3 2 2 1 2 1 2 1 3 1 2 1 2 2 3| 46 1.9| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + + + + M + + M + + + M + + +| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Cyst | 2 | 3 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 2 | 4 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 3 | 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 2 1 1 1 1 1 1 1 1 1 | 21 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 3 2 2 1 2 1 2 1 1 2 1 1| 27 1.6| Inflammation, Chronic Active | 1 2 2 3 3 | 7 2.1| Duct, Cyst | 2 2 2 2 2 2 2 2 3 2 2 2 3 3 2 2 3 3| 33 2.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 | 15 1.0| Inflammation, Chronic Active | 2 | 1 2.0| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 3 | 2 3.0| Inflammation, Chronic Active | 2 | 2 2.5| Bilateral, Dilatation | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Lymphoid | 3 2 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Hyperplasia, Lymphocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 3 2 1 2 4 2 3 1 2 1 | 22 2.3| Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + M + + M M + +| 37 | Cyst | 1 1 1 | 9 1.4| Hemorrhage | | 1 4.0| Inflammation, Granulomatous | 3 | 1 3.0| Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Inflammation, Chronic Active | 4 3 3 | 4 3.0| Ulcer | 4 4 | 3 4.0| Epidermis, Hyperplasia | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Hyperostosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Neuron, Necrosis | | 2 1.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 | 4 1.0| Alveolar Epithelium, Hyperplasia | 2 4 | 3 2.7| Alveolus, Infiltration Cellular, | | | Histiocyte | | 3 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | X | 2 2.0| Inflammation, Chronic Active | 1 | 1 1.0| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Atrophy | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 2 2 2 1 1 1 | 11 1.7| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 | 42 1.1| Inflammation, Chronic Active | 2 1 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0.0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Inflammation, Suppurative | | 1 2.0| Metaplasia, Osseous | 1 | 2 1.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0| Necrosis | | 1 2.0| Nephropathy | 2 1 1 1 1 1 2 1 1 2 1 1 1 2 1 2 1 2 1 1 1 2 1 1| 44 1.3| Pigmentation | 3 | 1 3.0| Cortex, Cyst | 3 2 | 5 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 | 6 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X X | Eosinophilic Focus | X X X X X X X| Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 1 1 1| Mineralization | | Mixed Cell Focus | X | Necrosis | | Bile Duct, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + | Mineralization | | Pigmentation | | Artery, Inflammation, Chronic Active | | Fat, Necrosis | 4 4 | __________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + +| Gingival, Foreign Body | X X X X X X X X X X X X X| Gingival, Inflammation, Chronic | | Active | 1 1 2 3 2 1 1 1 2 1| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 | Acinus, Atrophy | 4 | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 2 1 1 1 1 2 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Ectasia | 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Tooth | + + + +| Malformation | X X X X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Inflammation, Chronic Active | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation | 2 | Capsule, Hyperplasia | 1 1 1 2 1 1 1 2 1 1 1 1 2 1 1 1 2 2 1 1 2 2| Zona Fasciculata, Hyperplasia | 2 | Zona Fasciculata, Hypertrophy | 1 2 1 1 1 1 1 2 2 1 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 3 3 2 2 3 1 2 2 2 2 1 2 3 1 2 3 2 2 2 2 3| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Follicle, Cyst | 1 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | Inflammation, Chronic Active | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | Infiltration Cellular, Mononuclear | | Cell | 1 2 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 2 2 1 1 1 2 1 1 2 1 1 1 1 2| Inflammation, Chronic Active | 3 2 1 1 | Duct, Cyst | 2 2 2 2 3 3 2 3 3 2 2 2 2 3 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 3 | Infiltration Cellular, Mononuclear | | Cell | 1| Bilateral, Dilatation | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Renal, Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia, Plasma Cell | 3 2 | Infiltration Cellular, Eosinophil | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 3 | __________________________________________________________________________| Thymus | M + + M + + + M + + + + + + + + M + + M + M M + +| Cyst | 2 2 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Ulcer | 4 | Epidermis, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Alveolar Epithelium, Hyperplasia | 3 1 | Alveolus, Infiltration Cellular, | | Histiocyte | | Mediastinum, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.075% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Active | | Mediastinum, Pigmentation | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 3 | Inflammation, Chronic Active | 3 | Nasolacrimal Duct, Inflammation, | | Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + +| Hyperplasia | 2| Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 1 2 1 1 2 3 2| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Inflammation, Chronic Active | | Metaplasia, Osseous | 1 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | | Nephropathy | 1 1 1 1 2 1 1 2 1 2 1 1 1 2 1 2 1 1 1 1 1 1 2 2| Artery, Inflammation, Chronic Active | | Cortex, Cyst | 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 | Inflammation, Suppurative | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2| | | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Hyperplasia, Lymphoid | 3 | 2 3.5| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X | 3 | Clear Cell Focus | X X X X | 6 | Eosinophilic Focus | X X X X X X X | 14 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1| 25 1.0| Mineralization | 1 | 1 1.0| Mixed Cell Focus | X | 2 | Necrosis | 2 2 2 2 | 4 2.0| Bile Duct, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + | 6 | Mineralization | 3 | 1 3.0| Pigmentation | 3 | 1 3.0| Artery, Inflammation, Chronic Active | 2 | 1 2.0| Fat, Necrosis | 4 4 | 4 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + | 27 | Gingival, Foreign Body | X X X X X X X X X X X X X X | 27 | Gingival, Inflammation, Chronic | | | Active | 2 2 1 1 2 1 2 2 1 1 1 1 | 22 1.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | | 2 1.0| Acinus, Atrophy | | 1 4.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.1| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2| | | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Glands, Ectasia | 1 1 1 1 1 1 1 1| 18 1.0| __________________________________________________________________________|____________| Tooth | +| 5 | Malformation | | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Artery, Inflammation, Chronic Active | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pigmentation | | 1 2.0| Capsule, Hyperplasia | 2 1 1 1 2 3 1 2 1 1 1 2 2 1 1 1 1 2 1 1| 42 1.4| Zona Fasciculata, Hyperplasia | | 1 2.0| Zona Fasciculata, Hypertrophy | 1 2 2 1 2 2 2 2 2 1 1 1 | 24 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2 1 3 2 2| 47 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Pars Distalis, Cyst | 1 | 2 1.0| Pars Distalis, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| Follicle, Cyst | | 1 1.0| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + | 1 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 3.0| Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2| | | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cell | 1 1 1 1 1 1 1 1 1 1| 22 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 2 1 1 1 1 1 1 1 2| 28 1.3| Inflammation, Chronic Active | 2 2 2 2 | 8 1.9| Duct, Cyst | 1 2 3 2 3 3 3 2 2 2 2 2 3 2 2 2| 32 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 1 1 1 1 2 | 22 1.1| Inflammation, Chronic Active | 2 2 | 2 2.0| Artery, Inflammation, Chronic Active | 2 3 | 2 2.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | | 2 3.5| Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| Bilateral, Dilatation | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | | 1 | Renal, Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Ectasia | 3 | 1 3.0| Hyperplasia, Plasma Cell | | 2 2.5| Infiltration Cellular, Eosinophil | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 2 2 1 1 2 2 | 11 1.8| __________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + + + + M + + + + + M + + M| 39 | Cyst | 1 2 1 2 1 2 | 14 1.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| Ulcer | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2| | | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Epidermis, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 | 1 1.0| Mediastinum, Inflammation, Chronic | | | Active | 3 | 1 3.0| Mediastinum, Pigmentation | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | | 1 3.0| Inflammation, Chronic Active | | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 4 | Hyperplasia | | 1 2.0| Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 2 2 | 10 1.8| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 2 2 1 1 1 1 2 1 1 1 1 1 1 | 41 1.1| Inflammation, Chronic Active | 2 | 1 2.0| Metaplasia, Osseous | 1 | 3 1.0| Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0| Necrosis | 2 | 1 2.0| Nephropathy | 1 1 1 1 1 2 1 1 1 3 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2| | | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 0.075% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Artery, Inflammation, Chronic Active | 2 2 | 2 2.0| Cortex, Cyst | 2 2 2 1 2 2 2| 9 1.8| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 | 7 1.0| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Intussusception | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X X X X X | Eosinophilic Focus | X X X X X X X X | Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Mononuclear | | Cell | 1 | Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 | Mixed Cell Focus | X X X X| Necrosis | 4 1 1 1 2 | Pigmentation | 1 | Vacuolization Cytoplasmic | 1 | Bile Duct, Hyperplasia | 2 | Hepatocyte, Karyomegaly | 1 | __________________________________________________________________________| Mesentery | + + + + + + | Inflammation, Granulomatous | 3 4 | Pigmentation | 4 | Fat, Necrosis | 4 4 | __________________________________________________________________________| Oral Mucosa | + + + + + + + | Gingival, Foreign Body | X X X X X X X | Gingival, Inflammation, Chronic | | Active | 1 2 2 1 1 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 | Acinus, Hypertrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Epithelium, Hyperplasia | 2 | Epithelium, Inflammation, Chronic | | Active | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Epithelium, Erosion | 1 | Epithelium, Hyperplasia | 2 | Glands, Ectasia | 1 1 2 1 1 1 1 1 1 1| __________________________________________________________________________| Tooth | + + | Malformation | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 2 1 | Degeneration, Fatty | 1| Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 2 3| Zona Fasciculata, Hypertrophy | 1 1 1 2 1 1 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 2 3 2 2 2 3 1 2 2 2 3 1 2 1 2 3 2 2 2 2 3| __________________________________________________________________________| Parathyroid Gland | + + + + + + M M M + + M + + + M + + + + M + + + +| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 2 1 1 1 1 2 1 1 | Inflammation, Chronic Active | 2 2 | Inflammation, Suppurative | 2 3 | Duct, Cyst | 2 3 2 2 1 1 2 1 2 1 2 2 2 2 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | 2 1 | Inflammation, Suppurative | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Suppurative | 4 | Bilateral, Dilatation | 4| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Necrosis | 2 | Interstitial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +| Hemorrhage | | Thrombosis | | Myeloid Cell, Hyperplasia | 4 | __________________________________________________________________________| Lymph Node | + + | Lumbar, Hyperplasia, Plasma Cell | 3 | Renal, Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mandibular | M + M + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia, Plasma Cell | | Hyperplasia, Lymphocyte | 4 | Inflammation, Granulomatous | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 1 4 3 2 1 3 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + M + M M + M + + + + + + + + + + + + + + + + +| Cyst | 1 1 1 1 2 1 1 1 1 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Ulcer | 3 | Epidermis, Hyperplasia | 2 | Subcutaneous Tissue, Infiltration | | Cellular, Mononuclear Cell | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.15% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Mineralization | | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 3| Interstitium, Inflammation, Chronic | | Active | 2| Mediastinum, Inflammation, | | Suppurative | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + M + + + + + + + + + + +| Foreign Body | X | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Infarct | 2 4 2 2 2 2 3| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Infiltration Cellular, Plasma Cell | 2 | Inflammation, Suppurative | 3 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| Nephropathy | 1 1 1 1 1 3 1 2 1 2 1 2 1 1 1 1 3 1 1 2 1 1 2| Artery, Inflammation, Chronic Active | 2 | Cortex, Cyst | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| | | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| Intussusception | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | X X X X X | 10 | Eosinophilic Focus | X X X X X X | 14 | Hematopoietic Cell Proliferation | | 1 1.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 3 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.1| Mixed Cell Focus | X X X | 7 | Necrosis | 2 | 6 1.8| Pigmentation | 2 | 2 1.5| Vacuolization Cytoplasmic | 2 2 | 3 1.7| Bile Duct, Hyperplasia | | 1 2.0| Hepatocyte, Karyomegaly | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + | 7 | Inflammation, Granulomatous | | 2 3.5| Pigmentation | | 1 4.0| Fat, Necrosis | 4 | 3 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + | 17 | Gingival, Foreign Body | X X X X X X X X X X | 17 | Gingival, Inflammation, Chronic | | | Active | 1 1 2 1 2 1 1 2 | 14 1.4| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 3 1.0| Acinus, Hypertrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| | | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| Epithelium, Hyperplasia | 2 | 2 2.0| Epithelium, Inflammation, Chronic | | | Active | 1 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Epithelium, Erosion | | 1 1.0| Epithelium, Hyperplasia | 1 | 2 1.5| Glands, Ectasia | 1 1 1 1 1 1 | 16 1.1| __________________________________________________________________________|____________| Tooth | + + | 4 | Malformation | X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 2 2 | 6 1.7| Degeneration, Fatty | | 1 1.0| Capsule, Hyperplasia | 1 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1| 40 1.2| Zona Fasciculata, Hypertrophy | 1 3 1 2 1 | 14 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 1 2 2 1 2 1 3 2 2 1 2 1 2 2 2 2 3 2 2 2| 49 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + M + + + + + + M M M + + + M + +| 38 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + I + + + I + + + + + + + + + + +| 47 | Pars Distalis, Cyst | 2 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| | | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Atrophy | 3 | 1 3.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 1 1| 29 1.2| Inflammation, Chronic Active | 2 2 | 4 2.0| Inflammation, Suppurative | | 2 2.5| Duct, Cyst | 2 2 2 2 2 2 2 3 2 2 2 2 3 3 2 2 2 2| 33 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0| Inflammation, Chronic Active | 3 | 3 2.0| Inflammation, Suppurative | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| Inflammation, Suppurative | | 1 4.0| Bilateral, Dilatation | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Necrosis | | 1 2.0| Interstitial Cell, Hyperplasia | 4 | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 2 | 1 2.0| Thrombosis | 2 | 1 2.0| Myeloid Cell, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + | 3 | Lumbar, Hyperplasia, Plasma Cell | | 1 3.0| Renal, Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Lymphoid | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Hyperplasia, Plasma Cell | 3 | 1 3.0| Hyperplasia, Lymphocyte | | 1 4.0| Inflammation, Granulomatous | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| | | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 1 2 2 1 3 2 | 14 2.1| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + M M + M M M M M + + + + M + + + +| 38 | Cyst | 1 2 1 2 2 2 | 16 1.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Ulcer | | 1 3.0| Epidermis, Hyperplasia | | 1 2.0| Subcutaneous Tissue, Infiltration | | | Cellular, Mononuclear Cell | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| Mineralization | 1 1 1 | 3 1.0| Alveolar Epithelium, Hyperplasia | 1 3 1 1 1 | 6 1.5| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 | 2 3.0| Interstitium, Inflammation, Chronic | | | Active | | 1 2.0| Mediastinum, Inflammation, | | | Suppurative | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Foreign Body | 2 1 | 3 1.5| Inflammation, Chronic Active | 2 1 | 2 1.5| Inflammation, Suppurative | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| | | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 0.15% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 2 | 1 2.0| Infarct | 2 1 | 9 2.2| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0| Infiltration Cellular, Plasma Cell | | 1 2.0| Inflammation, Suppurative | | 1 3.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0| Nephropathy | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.2| Artery, Inflammation, Chronic Active | | 1 2.0| Cortex, Cyst | 2 2 3 1 1| 6 1.8| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1| 16 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| Ectasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Inflammation, | | Granulomatous | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X X X X | Eosinophilic Focus | X X X X X | Hematopoietic Cell Proliferation | 2 | Infiltration Cellular, Mononuclear | | Cell | | Inflammation, Chronic Active | 1 2 2 1 1 1 1 1 1 1 | Mineralization | | Mixed Cell Focus | X X | Necrosis | | Pigmentation | | Vacuolization Cytoplasmic | 2 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | | __________________________________________________________________________| Mesentery | + + + + + | Fat, Necrosis | 4 4 | __________________________________________________________________________| Oral Mucosa | + + + + + + + + + + | Gingival, Foreign Body | X X X X X X X X X X | Gingival, Inflammation, Chronic | | Active | 1 1 1 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mineralization | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | Epithelium, Hyperplasia | 1 2 | Epithelium, Inflammation, Chronic | | Active | 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | 2 3 2 2 1 2 | Epithelium, Necrosis | | Glands, Ectasia | 1 2 2 1 1 1 1 1 | __________________________________________________________________________| Tooth | | Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 2 | Capsule, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1| Zona Fasciculata, Hyperplasia | 2 | Zona Fasciculata, Hypertrophy | 1 1 1 1 1 1 1 1 1 2 1 1| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 3 3 2 2 2 3 2 2 1 2 2 2 2 2 2 1 2 2 2| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + M M + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + M + + +| Pars Distalis, Cyst | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 | Infiltration Cellular, Mixed Cell | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 2 1 1 1 1 1 1 2 2 1 1 1 | Inflammation, Chronic Active | 2 1 | Duct, Cyst | 2 2 2 2 3 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Infiltration Cellular, Mononuclear | | Cell | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Germinal Epithelium, Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Hemorrhage | | Mediastinal, Inflammation, | | Granulomatous | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Inflammation, Chronic Active | 3 | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 4 2 3 2 1 1 1 2| __________________________________________________________________________| Thymus | + + M + + + + + + M + + + + + M M + + + + + + + +| Cyst | 1 2 2 1 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | Necrosis | 4 | Alveolar Epithelium, Hyperplasia | 1 2 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.30% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Infarct | 2 2 2 4 2 1 2 2 1 2 | Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic Active | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Cortex, Cyst | 1 | Renal Tubule, Hypertrophy, Focal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Mononuclear | | Cell | 1 1 1 1 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2| | | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ectasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Inflammation, | | | Granulomatous | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 1 | Clear Cell Focus | X X X | 7 | Eosinophilic Focus | X X | 7 | Hematopoietic Cell Proliferation | | 1 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 | 1 1.0| Inflammation, Chronic Active | 1 1 1 1 1 1 3 1 1 | 19 1.2| Mineralization | 1 1 | 2 1.0| Mixed Cell Focus | X X X X X X X | 9 | Necrosis | 3 4 | 2 3.5| Pigmentation | 2 | 1 2.0| Vacuolization Cytoplasmic | | 1 2.0| Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Hyperplasia | 2 1 | 2 1.5| __________________________________________________________________________|____________| Mesentery | | 5 | Fat, Necrosis | | 2 4.0| __________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + | 19 | Gingival, Foreign Body | X X X X X X X X X | 19 | Gingival, Inflammation, Chronic | | | Active | 3 2 1 2 2 1 | 11 1.6| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0| Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2| | | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 4.0| Epithelium, Hyperplasia | 1 | 3 1.3| Epithelium, Inflammation, Chronic | | | Active | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 2 2 2 | 10 2.0| Epithelium, Necrosis | 2 | 1 2.0| Glands, Ectasia | 1 2 1 1 1 1 | 14 1.2| __________________________________________________________________________|____________| Tooth | + | 1 | Malformation | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 2 | 4 2.0| Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 40 1.1| Zona Fasciculata, Hyperplasia | | 1 2.0| Zona Fasciculata, Hypertrophy | 1 1 1 1 2 1 1 1 1 | 21 1.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 3 2 2 2 2 3 2 2 2 2 2 2 2 1 2 1 2 2 1| 44 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + M + + M + + + + + + + M + + + + + + + M + M + +| 41 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| 47 | Pars Distalis, Cyst | 1 2 1 | 4 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Cyst | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 2.0| Infiltration Cellular, Mononuclear | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2| | | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0| Infiltration Cellular, Mixed Cell | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 2 1 1 2| 25 1.2| Inflammation, Chronic Active | 3 2 | 4 2.0| Duct, Cyst | 2 2 4 2 2 2 2 3 3 2 3 3 3 3 3 2 2 2 2| 39 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 28 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 4 | 1 4.0| Infiltration Cellular, Mononuclear | | | Cell | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 2 1.5| Germinal Epithelium, Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 4 | 2 3.5| __________________________________________________________________________|____________| Lymph Node | + + + | 5 | Mediastinal, Hemorrhage | 4 | 1 4.0| Mediastinal, Inflammation, | | | Granulomatous | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Inflammation, Chronic Active | | 1 3.0| Inflammation, Granulomatous | 4 | 2 3.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 3 2 3 1 1 4 4 1 2 3| 20 2.2| __________________________________________________________________________|____________| Thymus | + + + + + + M + M + + + + + + M + + + + + + M + +| 42 | Cyst | 2 1 2 2 2| 9 1.7| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 4| 2 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 88007-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SODIUM NITRITE Date: 05/13/99 Route: DOSED WATER Time: 09:43:12 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2| | | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 0.30% | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Ulcer | 4 4| 2 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 4.0| Necrosis | 4 | 2 4.0| Alveolar Epithelium, Hyperplasia | 4 1 2 2 1 | 9 1.7| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 2 | 3 2.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 2 | 1 2.0| Infarct | 2 2 2 | 13 2.0| Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0| Cortex, Cyst | 2 2 1 | 4 1.5| Renal Tubule, Hypertrophy, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Mononuclear | | | Cell | 1 1 1 1 1 1| 10 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------