TDMS Study 88031-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DIPROPYLENE GLYCOL DATE: 02/04/02
EXPERIMENT: 88031 TEST: 05 TIME: 10:32:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55388 ROUTE: DOSED WATER NTP C#: C88031
PATHOLOGIST: MISSING CAS: 25265-71-8
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FINAL#3
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DIPROPYLENE GLYCOL DATE: 02/04/02
EXPERIMENT: 88031 TEST: 05 TIME: 10:32:00
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55388 ROUTE: DOSED WATER NTP C#: C88031
PATHOLOGIST: MISSING CAS: 25265-71-8
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 261 323 376 511 564 564 565 568 569 582 |
| 584 636 645 653 653 654 667 673 676 679 |
| 687 697 697 698 698 717 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 417 456 505 528 550 554 558 564 586 614 |
| 649 649 661 680 684 698 709 711 716 717 |
| 721 726 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 340 543 562 564 583 584 586 598 617 619 |
| 623 627 627 647 649 649 674 682 698 712 |
| 718 725 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 398 408 431 438 449 483 484 484 484 502 |
| 507 525 529 532 543 554 561 564 564 564 |
| 565 574 578 584 586 589 596 598 598 610 |
| 610 613 613 614 614 617 619 624 627 627 |
| 627 629 631 640 645 647 653 673 682 690 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 98.0 96.0 94.0 94.0 92.0 78.0 68.0 46.0 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 82.0 74.0 54.0 |
| | |
| | |
|1.0% | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 84.0 68.0 54.0 |
| | |
| | |
|4.0% | 100.0 100.0 100.0 100.0 96.0 82.0 70.0 42.0 6.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 0.25% 1.0% 4.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 46.0% 54.0% 54.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P