TDMS Study 88031-06 Pathology Tables
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25265-71-8
Lock Date: 04/20/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 11 11 8 7
Moribund Sacrifice 2 1 4 6
Accidently Killed 4
Survivors
Terminal Sacrifice 37 38 38 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (49)
Ulcer 1 (2%)
Gallbladder (50) (50) (49) (50)
Epithelium, Cyst 5 (10%) 1 (2%) 1 (2%) 1 (2%)
Epithelium, Cytoplasmic Alteration 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Epithelium, Hyperplasia, Focal 1 (2%)
Muscularis, Inflammation, Chronic 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Peyer's Patch, Inflammation, Acute 1 (2%) 1 (2%)
Serosa, Fibrosis 1 (2%)
Intestine Small, Ileum (50) (50) (50) (50)
Epithelium, Inflammation, Chronic 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Angiectasis, Focal 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Basophilic Focus 2 (4%) 1 (2%) 1 (2%)
Clear Cell Focus 5 (10%) 5 (10%) 2 (4%) 8 (16%)
Eosinophilic Focus 21 (42%) 13 (26%) 16 (32%) 17 (34%)
Hepatodiaphragmatic Nodule 1 (2%)
Infiltration Cellular, Lymphocyte 30 (60%) 39 (78%) 35 (70%) 30 (60%)
Inflammation, Chronic 36 (72%) 33 (66%) 35 (70%) 34 (68%)
Inflammation, Focal, Suppurative 1 (2%)
Mixed Cell Focus 14 (28%) 19 (38%) 21 (42%) 15 (30%)
Necrosis, Focal 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic, Focal 4 (8%) 10 (20%) 9 (18%) 10 (20%)
Sinusoid, Amyloid Deposition 1 (2%)
Mesentery (11) (18) (13) (14)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic 1 (7%)
Fat, Necrosis 11 (100%) 13 (72%) 11 (85%) 13 (93%)
Vein, Thrombosis 1 (6%)
Pancreas (50) (50) (50) (50)
Inflammation, Granulomatous 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Acinus, Vacuolization Cytoplasmic, Focal 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (49) (49) (49) (49)
Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hyperplasia, Squamous 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Inflammation, Focal, Suppurative 1 (2%)
Ulcer 3 (6%) 1 (2%) 1 (2%)
Epithelium, Cyst 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Mineralization, Focal 4 (8%) 2 (4%) 5 (10%)
Ulcer 1 (2%) 2 (4%)
Tooth (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Inflammation, Chronic 2 (4%)
Aorta, Mineralization 1 (2%) 3 (6%)
Heart (50) (50) (49) (50)
Cardiomyopathy 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Epicardium, Inflammation, Chronic Active 1 (2%)
Myocardium, Inflammation, Chronic Active,
Focal 2 (4%) 1 (2%)
Myocardium, Mineralization 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Valve, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 2 (4%)
Hypertrophy, Focal 3 (6%) 3 (6%) 2 (4%) 1 (2%)
Subcapsular, Hyperplasia 48 (96%) 49 (98%) 49 (100%) 48 (96%)
Adrenal Medulla (50) (49) (49) (50)
Hyperplasia, Focal 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 31 (62%) 29 (58%) 29 (58%) 33 (66%)
Pituitary Gland (49) (49) (49) (49)
Angiectasis 1 (2%)
Pars Distalis, Hyperplasia, Focal 6 (12%) 8 (16%) 6 (12%) 5 (10%)
Thyroid Gland (49) (48) (49) (48)
Inflammation, Granulomatous 1 (2%) 1 (2%) 2 (4%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (49) (49) (50)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Granulomatous 1 (2%)
Ovary (50) (50) (50) (50)
Angiectasis 3 (6%) 5 (10%) 2 (4%)
Cyst 12 (24%) 11 (22%) 15 (30%) 14 (28%)
Hemorrhage 2 (4%)
Periovarian Tissue, Infiltration Cellular,
Lymphocyte 1 (2%)
Oviduct (1)
Cyst 1 (100%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Endometrium, Hyperplasia, Cystic 38 (76%) 38 (76%) 39 (78%) 39 (78%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bone Marrow (50) (49) (50) (50)
Fibrosis 1 (2%)
Necrosis, Acute, Focal 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Lymph Node (5) (3) (1) (2)
Lumbar, Hematopoietic Cell Proliferation 1 (20%)
Lumbar, Infiltration Cellular, Plasma Cell 2 (40%)
Lumbar, Infiltration Cellular, Histiocyte 1 (20%)
Mediastinal, Congestion 1 (100%)
Mediastinal, Hyperplasia, Lymphoid 1 (100%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (20%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (20%)
Mediastinal, Pigmentation, Hemosiderin 1 (20%)
Pancreatic, Inflammation, Granulomatous 1 (100%)
Renal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mandibular (48) (45) (48) (48)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mesenteric (48) (48) (49) (49)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 2 (4%) 1 (2%)
Spleen (50) (50) (50) (50)
Hematopoietic Cell Proliferation 29 (58%) 24 (48%) 25 (50%) 24 (48%)
Inflammation, Granulomatous 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Lymphoid Follicle, Amyloid Deposition 1 (2%)
Lymphoid Follicle, Atrophy 12 (24%) 10 (20%) 10 (20%) 12 (24%)
Lymphoid Follicle, Hyperplasia 7 (14%) 8 (16%) 6 (12%) 7 (14%)
Thymus (49) (49) (48) (50)
Hyperplasia, Lymphoid 5 (10%) 1 (2%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49)
Hyperplasia 1 (2%) 1 (2%)
Duct, Hyperplasia, Squamous 1 (2%)
Skin (50) (50) (50) (50)
Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epidermis, Cyst 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrosis 4 (8%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (49) (50)
Hydrocephalus 2 (4%)
Necrosis, Acute, Focal 1 (2%)
Artery, Meninges, Inflammation, Chronic 1 (2%)
Hypothalamus, Compression 1 (2%) 2 (4%)
Peripheral Nerve (1)
Sciatic, Axon, Degeneration 1 (100%)
Spinal Cord (1)
Axon, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Congestion 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 3 (6%) 2 (4%) 4 (8%) 2 (4%)
Inflammation, Granulomatous 1 (2%) 3 (6%) 2 (4%)
Thrombosis 3 (6%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Mineralization 1 (2%)
Bronchus, Foreign Body 4 (8%)
Bronchus, Inflammation, Acute 1 (2%) 4 (8%)
Nose (50) (49) (50) (50)
Inflammation, Acute 3 (6%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Glands, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Atrophy 1 (50%)
Degeneration 1 (50%)
Cornea, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Hydronephrosis 2 (4%)
Infarct 4 (8%) 7 (14%) 9 (18%) 8 (16%)
Inflammation, Focal, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%) 3 (6%)
Nephropathy 12 (24%) 8 (16%) 15 (30%) 12 (24%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (50) (49) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 8 10 6
Moribund Sacrifice 3 3 5 9
Survivors
Terminal Sacrifice 39 39 35 34
Natural Death 1
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49)
Inflammation, Granulomatous 1 (2%)
Gallbladder (48) (48) (49) (48)
Epithelium, Cyst 1 (2%) 2 (4%)
Epithelium, Cytoplasmic Alteration 2 (4%) 1 (2%)
Epithelium, Mineralization 1 (2%)
Intestine Large, Colon (50) (50) (50) (49)
Inflammation, Suppurative 1 (2%)
Serosa, Inflammation, Granulomatous 1 (2%)
Intestine Large, Rectum (50) (50) (50) (49)
Epithelium, Hyperplasia, Focal 1 (2%)
Intestine Large, Cecum (50) (50) (50) (49)
Ulcer 1 (2%)
Intestine Small, Duodenum (50) (49) (50) (49)
Cyst 1 (2%)
Necrosis, Focal 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (49)
Hyperplasia 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 3 (6%)
Peyer's Patch, Infiltration Cellular, Plasma
Cell 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis, Focal 2 (4%) 1 (2%)
Basophilic Focus 2 (4%) 1 (2%) 3 (6%)
Clear Cell Focus 26 (52%) 24 (48%) 31 (62%) 12 (24%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Eosinophilic Focus 15 (30%) 28 (56%) 18 (36%) 11 (22%)
Fibrosis, Focal 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Chronic 23 (46%) 21 (42%) 20 (40%) 20 (41%)
Mixed Cell Focus 15 (30%) 20 (40%) 21 (42%) 7 (14%)
Necrosis, Focal 7 (14%) 5 (10%) 5 (10%) 5 (10%)
Vacuolization Cytoplasmic, Focal 3 (6%) 3 (6%) 4 (8%) 2 (4%)
Serosa, Fibrosis 1 (2%)
Mesentery (8) (10) (1)
Artery, Inflammation, Chronic 1 (10%)
Fat, Necrosis 7 (88%) 9 (90%) 1 (100%)
Pancreas (50) (50) (50) (49)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy, Focal 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (50) (50) (50) (49)
Atrophy, Focal 1 (2%)
Stomach, Forestomach (50) (50) (50) (49)
Hyperplasia, Squamous 2 (4%) 1 (2%) 3 (6%)
Inflammation, Focal, Suppurative 2 (4%)
Ulcer 2 (4%) 2 (4%)
Stomach, Glandular (50) (50) (50) (49)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 3 (6%)
Mineralization, Focal 3 (6%) 2 (4%)
Epithelium, Hyperplasia, Focal 2 (4%)
Epithelium, Inflammation, Focal, Suppurative 1 (2%)
Tooth (26) (22) (20) (7)
Malformation 26 (100%) 22 (100%) 20 (100%) 7 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (49)
Aorta, Inflammation, Chronic 1 (2%)
Pulmonary Artery, Mineralization 1 (2%)
Heart (50) (50) (50) (49)
Cardiomyopathy 3 (6%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Myocardium, Inflammation, Chronic Active,
Focal 2 (4%) 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Myocardium, Mineralization 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Hyperplasia, Focal 7 (14%) 4 (8%) 1 (2%)
Hypertrophy, Focal 28 (56%) 24 (48%) 23 (46%) 15 (31%)
Necrosis 1 (2%)
Subcapsular, Hyperplasia 47 (94%) 46 (92%) 44 (88%) 42 (86%)
Zona Fasciculata, Zona Reticularis,
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (50) (49) (50) (49)
Hyperplasia, Focal 2 (4%)
Islets, Pancreatic (50) (50) (50) (49)
Hyperplasia 40 (80%) 41 (82%) 39 (78%) 43 (88%)
Pituitary Gland (49) (48) (49) (49)
Pars Distalis, Hyperplasia, Focal 3 (6%) 3 (6%) 2 (4%) 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Inflammation, Granulomatous 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Atrophy 1 (2%)
Granuloma Sperm 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Syncytial Alteration 1 (2%)
Preputial Gland (50) (50) (50) (49)
Cyst 30 (60%) 32 (64%) 34 (68%) 34 (69%)
Cytoplasmic Alteration 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Suppurative 5 (10%) 3 (6%)
Bilateral, Cyst 1 (2%)
Prostate, NOS (50) (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 1 (2%)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Atrophy 2 (4%)
Cyst 4 (8%) 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Testes (50) (50) (50) (49)
Inflammation, Granulomatous 1 (2%)
Germinal Epithelium, Atrophy 1 (2%)
Interstitial Cell, Hyperplasia, Focal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (47) (49) (48) (47)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Megakaryocyte 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (48) (50) (49) (48)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (50) (50) (49)
Hematopoietic Cell Proliferation 15 (30%) 17 (34%) 14 (28%) 12 (24%)
Lymphoid Follicle, Atrophy 11 (22%) 12 (24%) 11 (22%) 13 (27%)
Lymphoid Follicle, Hyperplasia 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Thymus (46) (45) (47) (44)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Hyperkeratosis 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Bone (49) (50) (50) (49)
Fibrosis 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Hemorrhage 1 (2%)
Peripheral Nerve (1)
Axon, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Focal, Osseous 2 (4%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 3 (6%) 4 (8%) 3 (6%)
Artery, Mineralization 1 (2%)
Nose (50) (50) (50) (49)
Hyperostosis 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Cornea, Degeneration 1 (50%)
Cornea, Inflammation, Chronic 1 (100%)
Cornea, Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Glomerulosclerosis 1 (2%)
Hydronephrosis 2 (4%) 1 (2%)
Infarct 7 (14%) 14 (28%) 10 (20%) 9 (18%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Metaplasia, Osseous 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 09/26/01
Route: DOSED WATER Time: 14:32:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy 38 (76%) 37 (74%) 34 (68%) 36 (73%)
Papilla, Necrosis 2 (4%)
Renal Tubule, Cyst 2 (4%) 1 (2%) 2 (4%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Hyperplasia, Focal 3 (6%) 4 (8%) 2 (4%) 2 (4%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urethra (1)
Inflammation, Suppurative 1 (100%)
Urinary Bladder (50) (50) (50) (48)
Inflammation, Suppurative 1 (2%)
Transitional Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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