TDMS Study 88031-06 Pathology Tables
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
Final#1/Mice
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25265-71-8
Lock Date: 04/20/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 11 11 8 7
Moribund Sacrifice 2 1 4 6
Accidently Killed 4
Survivors
Terminal Sacrifice 37 38 38 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (49)
Intestine Large, Colon (50) (50) (50) (50)
Leiomyoma 1 (2%)
Polyp Adenomatous, Multiple 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (50)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Jejunum (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Sarcoma NOS 1 (2%)
Liver (50) (50) (50) (50)
Hemangioma 1 (2%) 1 (2%) 1 (2%)
Hemangiosarcoma 2 (4%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 6 (12%) 2 (4%) 1 (2%) 2 (4%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Adenoma 7 (14%) 11 (22%) 11 (22%) 10 (20%)
Hepatocellular Adenoma, Multiple 4 (8%) 3 (6%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%) 1 (2%)
Mesentery (11) (18) (13) (14)
Carcinoma NOS 1 (8%)
Fibrosarcoma 1 (8%)
Fibrosarcoma, Metastatic, Bone 1 (6%)
Liposarcoma 1 (6%)
Sarcoma 1 (8%)
Sarcoma NOS 2 (11%)
Pancreas (50) (50) (50) (50)
Page 2
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Sarcoma, Metastatic, Mesentery 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
Carcinoma, Metastatic, Tissue NOS 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Adrenal Medulla (50) (49) (49) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 2 (4%) 1 (2%)
Pituitary Gland (49) (49) (49) (49)
Pars Distalis, Adenoma 1 (2%) 3 (6%) 3 (6%) 3 (6%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (49) (48) (49) (48)
C-Cell, Carcinoma 1 (2%)
Follicle, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (49) (49) (50)
Ovary (50) (50) (50) (50)
Cystadenoma 2 (4%) 2 (4%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%)
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NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Uterus (50) (50) (50) (50)
Deciduoma Benign 1 (2%)
Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (5) (3) (1) (2)
Mediastinal, Sarcoma, Metastatic, Mesentery 1 (33%)
Pancreatic, Sarcoma, Metastatic, Mesentery 1 (33%)
Lymph Node, Mandibular (48) (45) (48) (48)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Lymph Node, Mesenteric (48) (48) (49) (49)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
Sarcoma NOS 1 (2%)
Spleen (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (49) (49) (48) (50)
Carcinoma, Metastatic, Tissue NOS 1 (2%)
Hemangioma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma NOS 2 (4%) 7 (14%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrosarcoma 1 (2%)
Skeletal Muscle (2)
Sarcoma 1 (50%)
Sarcoma NOS 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (49) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 4 (8%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Mesentery 1 (2%)
Carcinoma, Metastatic, Tissue NOS 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Skin 2 (4%)
Squamous Cell Carcinoma, Metastatic, Stomach,
Forestomach 1 (2%)
Mediastinum, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (3) (2) (4)
Adenoma 1 (100%) 2 (67%) 2 (100%) 3 (75%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (49) (49) (50)
Page 5
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant 5 (10%) 2 (4%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 32 35 30 29
Total Primary Neoplasms 49 46 44 42
Total Animals with Benign Neoplasms 22 24 22 21
Total Benign Neoplasms 24 24 28 27
Total Animals with Malignant Neoplasms 18 18 14 14
Total Malignant Neoplasms 25 22 15 15
Total Animals with Metastatic Neoplasms 3 6 4
Total Metastatic Neoplasm 5 10 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 7 8 10 6
Moribund Sacrifice 3 3 5 9
Survivors
Terminal Sacrifice 39 39 35 34
Natural Death 1
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (50) (50) (49)
Carcinoma 1 (2%)
Intestine Small, Duodenum (50) (49) (50) (49)
Hemangioma 1 (2%)
Polyp Adenomatous 1 (2%) 2 (4%)
Intestine Small, Jejunum (50) (50) (50) (49)
Carcinoma 1 (2%) 2 (4%) 3 (6%)
Polyp Adenomatous 1 (2%) 1 (2%)
Liver (50) (50) (50) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hemangioma 1 (2%) 1 (2%) 2 (4%)
Hemangiosarcoma 3 (6%) 1 (2%) 2 (4%)
Hepatoblastoma 4 (8%) 1 (2%)
Hepatocellular Carcinoma 11 (22%) 7 (14%) 8 (16%) 9 (18%)
Hepatocellular Carcinoma, Multiple 3 (6%) 3 (6%) 3 (6%) 7 (14%)
Hepatocellular Adenoma 10 (20%) 14 (28%) 14 (28%) 4 (8%)
Hepatocellular Adenoma, Multiple 7 (14%) 3 (6%) 6 (12%) 2 (4%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (8) (10) (1)
Pancreas (50) (50) (50) (49)
Stomach, Forestomach (50) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (49)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Adrenal Medulla (50) (49) (50) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 1 (2%)
Pituitary Gland (49) (48) (49) (49)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Follicle, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (49)
Preputial Gland (50) (50) (50) (49)
Hemangiosarcoma 1 (2%)
Seminal Vesicle (50) (50) (50) (49)
Testes (50) (50) (50) (49)
Interstitial Cell, Adenoma 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node (1)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (100%)
Lymph Node, Mesenteric (48) (50) (49) (48)
Carcinoma, Metastatic, Intestine Large, Cecum 1 (2%)
Page 9
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (46) (45) (47) (44)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Pinna, Ear, Neural Crest Tumor 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (1)
Hepatoblastoma, Metastatic, Liver 1 (100%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 3 (6%) 9 (18%) 4 (8%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 3 (6%) 6 (12%) 4 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) 2 (4%) 2 (4%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 6 (12%) 2 (4%) 4 (8%)
Histiocytic Sarcoma 1 (2%)
Nose (50) (50) (50) (49)
Glands, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (3) (4) (1)
Adenoma 2 (67%) 3 (100%) 4 (100%) 1 (100%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Renal Tubule, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(49)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 88031-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC DIPROPYLENE GLYCOL Date: 05/15/01
Route: DOSED WATER Time: 09:37:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0% 1.0% 2.0% 4.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 37 39 33
Total Primary Neoplasms 54 57 62 38
Total Animals with Benign Neoplasms 27 23 26 11
Total Benign Neoplasms 31 34 32 12
Total Animals with Malignant Neoplasms 19 19 26 25
Total Malignant Neoplasms 22 22 30 26
Total Animals with Metastatic Neoplasms 7 6 3 6
Total Metastatic Neoplasm 8 6 6 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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