TDMS Study 88031-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DIPROPYLENE GLYCOL DATE: 05/15/01
EXPERIMENT: 88031 TEST: 06 TIME: 09:47:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55388 ROUTE: DOSED WATER NTP C#: C88031
PATHOLOGIST: RYAN, MICHAEL CAS: 25265-71-8
------------------------------------------------------------------------------------------------------------------------------------
Final#1/Mice
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DIPROPYLENE GLYCOL DATE: 05/15/01
EXPERIMENT: 88031 TEST: 06 TIME: 09:47:03
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55388 ROUTE: DOSED WATER NTP C#: C88031
PATHOLOGIST: RYAN, MICHAEL CAS: 25265-71-8
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 416 546 556 575 592 603 629 666 708 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 224 405 405 491 501 561 588 619 661 686 |
| 710 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 494 518 542 575 616 640 645 645 661 666 |
| 672 676 706 708 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 1 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 416 416 451 464 513 515 533 582 610 661 |
| 661 668 688 708 710 |
| CENSORED DEATHS |
| 366 |
| |
==================================================================================
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 100.0 100.0 98.0 98.0 98.0 88.0 86.0 80.0 |
| | |
| | |
|1.0% | 100.0 100.0 98.0 98.0 94.0 94.0 90.0 86.0 82.0 78.0 |
| | |
| | |
|2.0% | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 82.0 70.0 |
| | |
| | |
|4.0% | 100.0 100.0 100.0 100.0 95.9 91.8 85.7 83.7 77.6 69.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 1.0% 2.0% 4.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 78.0% 70.0% 69.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.204 P=0.921 P=0.382 P=0.292 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 601.5 531.9 632.7 573.1 |
|NATURAL DEATHS (C) | (28.2) (44.0) (18.2) (27.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 703.5 685.6 700.1 675.0 |
|(STANDARD ERROR) | ( 9.1) (14.9) ( 8.3) (14.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 193 497 570 599 621 641 651 683 693 699 |
| 704 721 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 494 543 561 585 641 643 671 687 689 693 |
| 711 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 340 406 484 515 543 576 576 599 654 654 |
| 693 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 4 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 20 228 395 452 501 501 504 542 565 647 |
| 654 687 698 |
| CENSORED DEATHS |
| 542 542 542 542 |
| |
==================================================================================
DIPROPYLENE GLYCOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0% | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 92.0 86.0 74.0 |
| | |
| | |
|1.0% | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 88.0 76.0 |
| | |
| | |
|2.0% | 100.0 100.0 100.0 98.0 96.0 94.0 90.0 84.0 80.0 76.0 |
| | |
| | |
|4.0% | 98.0 98.0 96.0 96.0 94.0 92.0 84.0 81.8 77.4 72.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0% 1.0% 2.0% 4.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 76.0% 76.0% 72.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.702 P=0.989N P=1.000N P=0.873 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 615.2 637.0 562.3 491.8 |
|NATURAL DEATHS (C) | (39.7) (21.4) (32.5) (53.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 698.7 706.2 688.2 651.7 |
|(STANDARD ERROR) | (12.3) ( 7.5) (12.6) (20.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIPROPYLENE GLYCOL
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
1.0% = 2
2.0% = 3
4.0% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
|
| 2 2 1 3 3 1
| 4 4 3 1 1
95 +
| 2 4 4 2 3 1 1
P | 22 1 1 3
E | 4 4
R 90 + 2 2 1 13 3
C |
E | 4 4 2 2 1 1 33
N | 4 2 21 1
T 85 +
| 4 42 3 21 1
S | 23 2 1 1
U | 4 4
R 80 + 2 2 1 1
V |
I | 433 2 2
V | 3 3
A 75 + 4 4
L | 4 33
| 3 3
|
70 + 4 3 3
|
|
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
DIPROPYLENE GLYCOL
KAPLAN-MEIER SURVIVAL CURVES
0.0% = 1
1.0% = 2
2.0% = 3
4.0% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 3 2
|
| 4 1 4 3 3 1 2
| 4 43 31 2 21
P 95 +
E | 4 4 3 3 21 2 1
R | 4 4 3 3 2 1 1 2
C |
E 90 + 3 3 1 1
N |
T | 11 2
| 4 4 3 3 1 2 12
S 85 +
U | 4 4 3 3 11
R | 11
V | 4 4
I 80 + 43 2112
V |
A | 4 3 1212
L | 311
75 + 44
| 1
| 4 4
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.