TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
53 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 434-07-01
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 04/21/94 - 04/22/94
Treatment Groups: Include 002 0 MG/KG
Include 004 3 MG/KG
Include 006 30 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 3 MG/KG
Include 005 30 MG/KG
Include 007 150 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 90 90 90
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (10) (10) (10) (10)
Parasite Metazoan 1 (10%)
Intestine Large, Rectum (10) (10) (10) (10)
Parasite Metazoan 2 (20%) 3 (30%)
Intestine Large, Cecum (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Liver (10) (10) (10) (10)
Basophilic Focus 4 (40%) 8 (80%) 2 (20%) 7 (70%)
Clear Cell Focus 1 (10%) 1 (10%)
Eosinophilic Focus 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%) 2 (20%) 2 (20%) 1 (10%)
Inflammation, Chronic Active 7 (70%) 5 (50%) 6 (60%) 3 (30%)
Bile Duct, Hyperplasia 1 (10%)
Centrilobular, Vacuolization Cytoplasmic 7 (70%)
Mesentery (1) (3) (3) (1)
Fat, Inflammation, Chronic Active 1 (100%) 3 (100%) 3 (100%) 1 (100%)
Pancreas (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Acinus, Atrophy 2 (20%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Myocardium, Degeneration, Chronic 7 (70%) 8 (80%) 9 (90%) 9 (90%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 3 (30%) 2 (20%) 1 (10%)
Hyperplasia 1 (10%)
Inflammation, Chronic Active 1 (10%)
Vacuolization Cytoplasmic 10 (100%)
Pituitary Gland (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 2 (20%) 1 (10%)
Pars Distalis, Angiectasis 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Ultimobranchial Cyst 1 (10%)
Follicle, Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10) (10) (10)
Cyst 1 (10%)
Inflammation, Chronic Active 4 (40%) 6 (60%) 6 (60%) 3 (30%)
Ovary (10) (10) (10) (10)
DYSGENESIS 10 (100%) 10 (100%)
Follicle, Cyst 1 (10%)
Periovarian Tissue, Cyst 1 (10%)
Uterus (10) (10) (10) (10)
Hydrometra 1 (10%) 1 (10%)
Endometrium, Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10)
Myelofibrosis 1 (10%)
Spleen (10) (10) (10) (10)
Lymphoid Follicle, Depletion Cellular 1 (10%)
Thymus (10) (10) (9) (10)
Atrophy 2 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10)
Dilatation 1 (10%) 8 (80%)
Lobular, Hyperplasia 10 (100%) 8 (80%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (10%) 4 (40%) 3 (30%)
Mineralization 2 (20%) 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 9 (90%) 10 (100%) 10 (100%) 10 (100%)
Nephropathy 5 (50%) 6 (60%) 9 (90%) 10 (100%)
Urinary Bladder (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 90 90 90
Scheduled Sacrifice 9 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 9 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (9) (10) (10) (10)
Parasite Metazoan 4 (40%) 1 (10%)
Intestine Large, Cecum (9) (10) (10) (10)
Parasite Metazoan 1 (10%)
Intestine Small, Ileum (9) (10) (10) (10)
Peyer's Patch, Mineralization 1 (10%)
Liver (9) (10) (9) (10)
Basophilic Focus 2 (20%) 2 (22%)
Clear Cell Focus 1 (10%)
Cyst 1 (11%)
Hepatodiaphragmatic Nodule 2 (22%) 1 (10%) 1 (11%) 1 (10%)
Inflammation, Chronic Active 6 (67%) 7 (70%) 6 (67%)
Necrosis 4 (40%) 2 (22%)
Bile Duct, Hyperplasia 3 (33%) 5 (50%) 3 (33%)
Centrilobular, Vacuolization Cytoplasmic 2 (22%) 3 (30%) 1 (11%)
Mesentery (1)
Fat, Inflammation, Chronic Active 1 (100%)
Pancreas (9) (10) (10) (10)
Acinus, Atrophy 1 (11%) 3 (30%) 4 (40%) 3 (30%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (9) (10) (10) (10)
Myocardium, Degeneration, Chronic 8 (89%) 9 (90%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (9) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (11%) 1 (10%)
Hypertrophy 1 (11%)
Vacuolization Cytoplasmic 9 (100%) 7 (70%) 9 (90%) 8 (80%)
Pituitary Gland (9) (10) (10) (10)
Cyst 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (11%) 4 (40%) 3 (30%) 1 (10%)
Pars Nervosa, Developmental Malformation 1 (11%)
Thyroid Gland (9) (10) (10) (10)
Ultimobranchial Cyst 1 (10%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (9) (10) (10) (10)
Inflammation, Chronic Active 6 (67%) 6 (60%) 9 (90%) 7 (70%)
Testes (9) (10) (10) (10)
Degeneration 1 (10%)
Mineralization 2 (20%) 3 (30%) 6 (60%)
Interstitial Cell, Hyperplasia 8 (89%) 7 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (10) (10) (10)
Congestion 1 (11%) 1 (10%) 1 (10%)
Ectasia 1 (11%)
Lymph Node, Mesenteric (9) (10) (10) (10)
Atrophy 1 (10%)
Spleen (9) (10) (10) (10)
Red Pulp, Depletion Cellular 1 (11%)
Thymus (9) (10) (10) (10)
Atrophy 7 (70%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (8) (9) (10) (10)
Dilatation 4 (50%) 1 (11%) 5 (50%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:20:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (9) (10) (10) (10)
Hemorrhage 1 (11%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (11%) 3 (30%) 1 (10%) 2 (20%)
Mineralization 2 (22%) 1 (10%) 4 (40%) 4 (40%)
Vacuolization Cytoplasmic 1 (10%) 2 (20%)
Nose (9) (10) (10) (10)
Inflammation, Chronic Active 2 (22%) 1 (10%)
Inflammation, Suppurative 1 (11%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (9) (10) (10) (10)
Mineralization 1 (11%) 9 (90%)
Necrosis 1 (10%)
Nephropathy 9 (100%) 10 (100%) 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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