TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 79 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 434-07-01 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 10/20/94 - 10/21/94 Treatment Groups: Include 002 0 MG/KG Include 004 3 MG/KG Include 006 30 MG/KG Include 008 100 MG/KG Include 001 0 MG/KG Include 003 3 MG/KG Include 005 30 MG/KG Include 007 150 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 90 90 90 90 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hepatocellular Adenoma 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Medulla (10) (10) (10) (10) Pheochromocytoma Benign 1 (10%) Islets, Pancreatic (10) (10) (10) (10) Carcinoma 1 (10%) Pituitary Gland (10) (9) (10) (10) Pars Distalis, Adenoma 3 (30%) 3 (33%) 1 (10%) 2 (20%) Thyroid Gland (10) (10) (10) (10) C-Cell, Adenoma 2 (20%) 2 (20%) Follicular Cell, Carcinoma 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (9) (10) (8) (10) Adenoma 2 (20%) Uterus (10) (10) (10) (10) Carcinoma 1 (10%) Polyp Stromal 1 (10%) 1 (10%) 1 (10%) Page 2 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) (10) (10) Spleen (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (10) (10) (10) (10) Carcinoma 1 (10%) Fibroadenoma 3 (30%) 1 (10%) 1 (10%) 1 (10%) Skin (10) (10) (10) (10) Hemangiopericytoma 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Alveolar/Bronchiolar Adenoma 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Leukemia Mononuclear 1 (10%) * Number of animals with any tissue examined microscopically Page 3 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont Multiple Organs *(10) *(10) *(10) *(10) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 8 4 5 5 Total Primary Neoplasms 11 8 7 8 Total Animals with Benign Neoplasms 6 4 5 5 Total Benign Neoplasms 8 7 7 7 Total Animals with Malignant Neoplasms 3 1 1 Total Malignant Neoplasms 3 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 90 90 90 90 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (10) (10) (10) (10) Liver (10) (10) (10) (10) Pancreas (10) (10) (10) (10) Acinus, Adenoma 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Adrenal Medulla (10) (10) (10) (10) Pheochromocytoma Malignant 1 (10%) Pheochromocytoma Benign 1 (10%) 1 (10%) 1 (10%) Islets, Pancreatic (10) (10) (10) (10) Adenoma 1 (10%) Pituitary Gland (10) (10) (10) (9) Pars Distalis, Adenoma 2 (20%) 6 (60%) 9 (90%) 5 (56%) Thyroid Gland (10) (10) (10) (10) C-Cell, Adenoma 1 (10%) C-Cell, Carcinoma 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (10) (10) Adenoma 1 (10%) Carcinoma 1 (10%) Testes (10) (10) (10) (10) Bilateral, Interstitial Cell, Adenoma 7 (70%) 2 (20%) Interstitial Cell, Adenoma 2 (20%) 3 (30%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (10) (10) (10) (10) Lymph Node (1) Lymph Node, Mandibular (10) (10) (10) (10) Lymph Node, Mesenteric (10) (10) (10) (10) Spleen (10) (10) (10) (10) Thymus (10) (10) (9) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) Keratoacanthoma 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (9) (10) Chordoma, Metastatic, Uncertain Primary Site 1 (10%) Squamous Cell Carcinoma 1 (11%) Nose (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Leukemia Mononuclear 2 (20%) 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 10 10 9 6 Total Primary Neoplasms 15 14 14 8 Total Animals with Benign Neoplasms 10 10 9 6 Total Benign Neoplasms 12 13 12 7 Total Animals with Malignant Neoplasms 3 1 2 1 Total Malignant Neoplasms 3 1 2 1 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 1 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------