TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 53 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 434-07-01 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 04/21/94 - 04/22/94 Treatment Groups: Include 002 0 MG/KG Include 004 3 MG/KG Include 006 30 MG/KG Include 008 100 MG/KG Include 001 0 MG/KG Include 003 3 MG/KG Include 005 30 MG/KG Include 007 150 MG/KG Page 1 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | A | 0 MG/KG | 6| 8| 8| 8| 1| 2| 3| 3| 4| 5| | L | | 4| 0| 5| 6| 3| 3| 5| 7| 7| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X | 4 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 2 | 7 1.1| __________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| Acinus, Atrophy | 2 2 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + M M + + + + | 8 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 1 | 7 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 3 1 1 | 3 1.7| Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | A | 0 MG/KG | 6| 8| 8| 8| 1| 2| 3| 3| 4| 5| | L | | 4| 0| 5| 6| 3| 3| 5| 7| 7| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Periovarian Tissue, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Cyst | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0| Nephropathy | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | A | 0 MG/KG | 6| 8| 8| 8| 1| 2| 3| 3| 4| 5| | L | | 4| 0| 5| 6| 3| 3| 5| 7| 7| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 3 MG/KG | 5| 6| 8| 9| 0| 0| 0| 0| 2| 3| | L | | 3| 9| 3| 1| 0| 3| 7| 8| 8| 3| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X | 8 | Eosinophilic Focus | X | 1 | Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Inflammation, Chronic Active | 3 3 3 | 3 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 1 1 | 8 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 1 | 2 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 2 1 | 2 1.5| Pars Distalis, Angiectasis | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A | 3 MG/KG | 5| 6| 8| 9| 0| 0| 0| 0| 2| 3| | L | | 3| 9| 3| 1| 0| 3| 7| 8| 8| 3| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Hydrometra | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 1 | 1 1.0| Inflammation, Chronic Active | 1 1 2 1 | 4 1.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Nephropathy | 1 1 1 1 1 1 | 6 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A | 30 MG/KG | 4| 6| 7| 7| 8| 8| 0| 1| 1| 2| | L | | 1| 7| 6| 7| 2| 4| 2| 0| 3| 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X | 2 | Clear Cell Focus | X | 1 | Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0| Bile Duct, Hyperplasia | 1 | 1 1.0| Centrilobular, Vacuolization | | | Cytoplasmic | 2 1 1 2 1 1 1 | 7 1.3| __________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Inflammation, Chronic Active | 3 2 2 | 3 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 2 1 1 1 1 2 | 9 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + | 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ultimobranchial Cyst | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A | 30 MG/KG | 4| 6| 7| 7| 8| 8| 0| 1| 1| 2| | L | | 1| 7| 6| 7| 2| 4| 2| 0| 3| 9| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | DYSGENESIS | 2 1 2 2 2 1 2 2 1 2 | 10 1.7| Follicle, Cyst | 1 | 1 1.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 | 1 2.0| Lobular, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 | 10 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 | 3 1.0| Mineralization | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A | 30 MG/KG | 4| 6| 7| 7| 8| 8| 0| 1| 1| 2| | L | | 1| 7| 6| 7| 2| 4| 2| 0| 3| 9| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Nephropathy | 1 1 1 1 1 1 1 1 1 | 9 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | A | 100 | 3| 3| 5| 6| 7| 7| 8| 9| 0| 0| | L | MG/KG | 1| 8| 9| 9| 0| 3| 9| 8| 2| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X | 7 | Clear Cell Focus | X | 1 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 1 2 2 | 9 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + M + M M M + + + M | 5 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicle, Cyst | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | A | 100 | 3| 3| 5| 6| 7| 7| 8| 9| 0| 0| | L | MG/KG | 1| 8| 9| 9| 0| 3| 9| 8| 2| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | DYSGENESIS | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Hydrometra | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 2 1 2 2 1 1 2 | 8 1.6| Lobular, Hyperplasia | 2 1 2 1 2 2 2 2 | 8 1.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Mineralization | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | A | 100 | 3| 3| 5| 6| 7| 7| 8| 9| 0| 0| | L | MG/KG | 1| 8| 9| 9| 0| 3| 9| 8| 2| 8| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/KG | 1| 1| 2| 4| 4| 4| 7| 8| 9| | L | | 2| 5| 6| 0| 3| 9| 0| 1| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + | 9 | Cyst | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0| Bile Duct, Hyperplasia | 1 1 1 | 3 1.0| Centrilobular, Vacuolization | | | Cytoplasmic | 1 1 | 2 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 9 | Acinus, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Heart | + + + + + + + + + | 9 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 1 1 | 8 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + | 9 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Hypertrophy | 3 | 1 3.0| Vacuolization Cytoplasmic | 1 1 1 1 1 2 1 1 1 | 9 1.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 9 | Cyst | 3 | 1 3.0| Hyperplasia | 2 | 1 2.0| Pars Nervosa, Developmental | | | Malformation | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/KG | 1| 1| 2| 4| 4| 4| 7| 8| 9| | L | | 2| 5| 6| 0| 3| 9| 0| 1| 0| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + | 9 | Inflammation, Chronic Active | 1 1 1 1 2 2 | 6 1.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Testes | + + + + + + + + + | 9 | Interstitial Cell, Hyperplasia | 2 3 2 3 2 2 2 3 | 8 2.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + | 9 | Congestion | 2 | 1 2.0| Ectasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 9 | Red Pulp, Depletion Cellular | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + M + + + | 8 | Dilatation | 1 2 1 3 | 4 1.8| __________________________________________________________________________|____________| Skin | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 9 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + | 9 | Inflammation, Chronic Active | 2 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/KG | 1| 1| 2| 4| 4| 4| 7| 8| 9| | L | | 2| 5| 6| 0| 3| 9| 0| 1| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Suppurative | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + | 9 | Mineralization | 1 | 1 1.0| Nephropathy | 2 2 2 2 1 3 2 1 2 | 9 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3 MG/KG | 0| 0| 0| 0| 1| 3| 4| 5| 6| 7| | L | | 3| 6| 7| 8| 6| 7| 1| 6| 1| 2| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X | 2 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0| Necrosis | 1 1 1 1 | 4 1.0| Bile Duct, Hyperplasia | 1 1 1 1 1 | 5 1.0| Centrilobular, Vacuolization | | | Cytoplasmic | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 3 1 2 | 3 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 1 2 1 | 9 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Hyperplasia | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ultimobranchial Cyst | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3 MG/KG | 0| 0| 0| 0| 1| 3| 4| 5| 6| 7| | L | | 3| 6| 7| 8| 6| 7| 1| 6| 1| 2| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 2 1 2 | 6 1.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Mineralization | 1 1 | 2 1.0| Interstitial Cell, Hyperplasia | 2 1 1 1 2 3 2 | 7 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Congestion | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + I + + + | 9 | Dilatation | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 1 2 1 | 3 1.3| Mineralization | 1 | 1 1.0| Vacuolization Cytoplasmic | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3 MG/KG | 0| 0| 0| 0| 1| 3| 4| 5| 6| 7| | L | | 3| 6| 7| 8| 6| 7| 1| 6| 1| 2| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 2 1 1 1 2 1 2 1 | 10 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 MG/KG | 8| 9| 0| 1| 1| 2| 3| 5| 6| 6| | L | | 7| 1| 0| 4| 8| 3| 9| 5| 5| 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + | 9 | Basophilic Focus | X X | 2 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0| Necrosis | 1 1 | 2 1.0| Bile Duct, Hyperplasia | 1 1 1 | 3 1.0| Centrilobular, Vacuolization | | | Cytoplasmic | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 2 1 1 1 | 4 1.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 2 1 1 1 1 2 1 1 1 2 | 10 1.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 2 1 1 1 2 1 1 1 | 9 1.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Hyperplasia | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ultimobranchial Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 MG/KG | 8| 9| 0| 1| 1| 2| 3| 5| 6| 6| | L | | 7| 1| 0| 4| 8| 3| 9| 5| 5| 9| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 | 9 1.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Mineralization | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 1 1 1 1 | 5 1.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 1 1 | 4 1.0| Vacuolization Cytoplasmic | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 MG/KG | 8| 9| 0| 1| 1| 2| 3| 5| 6| 6| | L | | 7| 1| 0| 4| 8| 3| 9| 5| 5| 9| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Necrosis | 1 | 1 1.0| Nephropathy | 2 2 1 2 1 1 2 1 1 1 | 10 1.4| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | A | 150 | 8| 8| 9| 0| 1| 2| 3| 3| 4| 5| | L | MG/KG | 0| 3| 3| 6| 2| 4| 4| 8| 4| 3| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | Peyer's Patch, Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Clear Cell Focus | X | 1 | Hepatodiaphragmatic Nodule | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 2 1 1 1 | 10 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 | 8 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + M | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ultimobranchial Cyst | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | A | 150 | 8| 8| 9| 0| 1| 2| 3| 3| 4| 5| | L | MG/KG | 0| 3| 3| 6| 2| 4| 4| 8| 4| 3| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 2 1 1 1 1 1 | 7 1.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Degeneration | 1 | 1 1.0| Mineralization | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Congestion | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 2 2 2 2 3 2 2 | 7 2.1| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 3 2 2 2 2 2 2 2 1 2 | 10 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 | 2 1.0| Mineralization | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 10:59:00 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | A | 150 | 8| 8| 9| 0| 1| 2| 3| 3| 4| 5| | L | MG/KG | 0| 3| 3| 6| 2| 4| 4| 8| 4| 3| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 2 | 9 1.1| Nephropathy | 2 1 2 2 2 1 1 2 2 2 | 10 1.7| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------