TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 79 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 434-07-01 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 10/20/94 - 10/21/94 Treatment Groups: Include 002 0 MG/KG Include 004 3 MG/KG Include 006 30 MG/KG Include 008 100 MG/KG Include 001 0 MG/KG Include 003 3 MG/KG Include 005 30 MG/KG Include 007 150 MG/KG Page 1 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | A | 0 MG/KG | 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| | L | | 9| 2| 4| 6| 1| 4| 9| 6| 2| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X | 7 | Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Mesentery | + + + + | 4 | Fat, Inflammation, Chronic Active | 3 1 2 2 | 4 2.0| Fat, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 1 3 | 2 2.0| Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | A | 0 MG/KG | 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| | L | | 9| 2| 4| 6| 1| 4| 9| 6| 2| 8| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + | 9 | Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Periovarian Tissue, Cyst | 2 3 3 | 3 2.7| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Hydrometra | 2 2 3 | 3 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Pigmentation, Hemosiderin | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 2 1 2 | 4 1.8| Galactocele | 2 | 1 2.0| Lobular, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Epidermis, Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| Mineralization | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | A | 0 MG/KG | 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| | L | | 9| 2| 4| 6| 1| 4| 9| 6| 2| 8| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 | 8 1.0| Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| | A | 3 MG/KG | 5| 5| 7| 7| 8| 8| 9| 9| 1| 2| | L | | 1| 6| 1| 5| 0| 6| 2| 3| 8| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X X X | 10 | Clear Cell Focus | X | 1 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 2 1 1 1 1 1 | 6 1.2| __________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Inflammation, Chronic Active | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 2 1 1 1 1 1 | 7 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Angiectasis | 1 3 2 | 3 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + + + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + + | 9 | Cyst | 2 | 1 2.0| Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| | A | 3 MG/KG | 5| 5| 7| 7| 8| 8| 9| 9| 1| 2| | L | | 1| 6| 1| 5| 0| 6| 2| 3| 8| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Periovarian Tissue, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + M + + + + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 | 1 2.0| Galactocele | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 | 4 1.0| Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| | A | 3 MG/KG | 5| 5| 7| 7| 8| 8| 9| 9| 1| 2| | L | | 1| 6| 1| 5| 0| 6| 2| 3| 8| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0| Nephropathy | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | A | 30 MG/KG | 6| 8| 8| 0| 0| 0| 1| 1| 1| 3| | L | | 4| 3| 7| 0| 3| 6| 6| 7| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X X X | 10 | Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic Active | 1 1 1 1 2 1 1 | 7 1.1| Mixed Cell Focus | X X | 2 | Centrilobular, Vacuolization | | | Cytoplasmic | 1 1 1 1 1 1 1 1 1 | 9 1.0| __________________________________________________________________________|____________| Mesentery | + + | 2 | Fat, Inflammation, Chronic Active | 2 2 | 2 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 2 1 2 1 1 1 1 | 8 1.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + M + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 1 3 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | A | 30 MG/KG | 6| 8| 8| 0| 0| 0| 1| 1| 1| 3| | L | | 4| 3| 7| 0| 3| 6| 6| 7| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + M | 8 | Inflammation, Chronic Active | 1 1 | 2 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | DYSGENESIS | 2 1 3 3 2 3 2 3 | 8 2.4| Periovarian Tissue, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Lobular, Hyperplasia | 1 2 2 2 1 1 1 1 1 | 9 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 2 1 | 4 1.3| Mineralization | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Suppurative | 1 | 1 1.0| Glands, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| | A | 30 MG/KG | 6| 8| 8| 0| 0| 0| 1| 1| 1| 3| | L | | 4| 3| 7| 0| 3| 6| 6| 7| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Nephropathy | 1 1 1 2 1 1 1 2 1 | 9 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | A | 100 | 4| 5| 5| 6| 6| 6| 8| 9| 0| 2| | L | MG/KG | 9| 0| 6| 5| 6| 8| 3| 9| 6| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X X | 9 | Clear Cell Focus | X X X | 3 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 | 1 1.0| Bile Duct, Hyperplasia | 1 | 1 1.0| Centrilobular, Vacuolization | | | Cytoplasmic | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 1 2 2 2 1 2 2 | 9 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 1 1 2 3 1 2 1 1 | 9 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + M + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | C-Cell, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | A | 100 | 4| 5| 5| 6| 6| 6| 8| 9| 0| 2| | L | MG/KG | 9| 0| 6| 5| 6| 8| 3| 9| 6| 0| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 10 | Cyst | 3 3 3 | 3 3.0| Inflammation, Chronic Active | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | DYSGENESIS | 3 3 3 4 3 4 3 3 4 3 | 10 3.3| Periovarian Tissue, Cyst | 4 | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Hydrometra | 2 2 | 2 2.0| Endometrium, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 1 | 1 1.0| Lobular, Hyperplasia | 1 1 1 2 2 2 2 2 1 | 9 1.6| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 | 3 1.0| Mineralization | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | A | 100 | 4| 5| 5| 6| 6| 6| 8| 9| 0| 2| | L | MG/KG | 9| 0| 6| 5| 6| 8| 3| 9| 6| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0| Nephropathy | 1 1 1 2 1 1 2 2 2 2 | 10 1.5| Renal Tubule, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/KG | 0| 1| 3| 3| 4| 5| 5| 6| 7| 8| | L | | 6| 3| 5| 8| 1| 5| 8| 5| 9| 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X | 4 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X | 1 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0| Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 | 10 1.1| Centrilobular, Vacuolization | | | Cytoplasmic | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Congestion | 2 | 1 2.0| Fat, Inflammation, Chronic Active | 3 3 | 2 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 2 2 1 1 2 2 2 1 | 10 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | Hyperplasia | 3 1 2 | 3 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/KG | 0| 1| 3| 3| 4| 5| 5| 6| 7| 8| | L | | 6| 3| 5| 8| 1| 5| 8| 5| 9| 9| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Cyst | 2 2 | 2 2.0| Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Degeneration | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 1 | 2 1.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Degeneration | 3 3 | 2 3.0| Mineralization | 1 1 1 | 3 1.0| Interstitial Cell, Hyperplasia | 2 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 1 2 | 2 1.5| Galactocele | 2 1 | 2 1.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/KG | 0| 1| 3| 3| 4| 5| 5| 6| 7| 8| | L | | 6| 3| 5| 8| 1| 5| 8| 5| 9| 9| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Vacuolization Cytoplasmic | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 2 2 2 2 2 2 1 3 2 2 | 10 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3 MG/KG | 9| 2| 3| 3| 3| 4| 6| 6| 6| 7| | L | | 7| 7| 2| 4| 8| 9| 2| 6| 7| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X | 8 | Degeneration, Cystic | 1 | 1 1.0| Eosinophilic Focus | X | 1 | Hepatodiaphragmatic Nodule | X X | 2 | Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0| Mixed Cell Focus | X | 1 | Necrosis | 1 | 1 1.0| Bile Duct, Hyperplasia | 2 1 1 1 1 1 | 6 1.2| Centrilobular, Vacuolization | | | Cytoplasmic | 1 1 2 1 1 | 5 1.2| __________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 1 2 | 2 1.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 1 1 2 1 1 1 1 2 2 1 | 10 1.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 1 1 1 2 2 1 1 | 8 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3 MG/KG | 9| 2| 3| 3| 3| 4| 6| 6| 6| 7| | L | | 7| 7| 2| 4| 8| 9| 2| 6| 7| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Hyperplasia | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 2 2 1 1 1 | 8 1.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 3 | 2 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Degeneration | 3 | 1 3.0| Mineralization | 1 | 1 1.0| Interstitial Cell, Hyperplasia | 4 3 2 3 | 4 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 1 2 | 3 1.7| Galactocele | 3 | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Parakeratosis | 3 | 1 3.0| Ulcer | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3 MG/KG | 9| 2| 3| 3| 3| 4| 6| 6| 6| 7| | L | | 7| 7| 2| 4| 8| 9| 2| 6| 7| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 2 1 1 | 4 1.3| Mineralization | 1 1 1 1 | 4 1.0| Vacuolization Cytoplasmic | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Suppurative | 2 2 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 2 2 2 2 2 3 3 2 2 3 | 10 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 MG/KG | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| | L | | 3| 7| 1| 3| 5| 2| 1| 2| 4| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | Fibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X X | 9 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X | 1 | Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 | 1 1.0| Bile Duct, Hyperplasia | 1 2 1 3 2 1 | 6 1.7| Centrilobular, Vacuolization | | | Cytoplasmic | 1 1 | 2 1.0| __________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Inflammation, Chronic Active | 2 2 2 | 3 2.0| Fat, Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 3 1 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 2 2 2 2 2 1 2 1 1 1 | 10 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 2 2 2 2 2 1 2 2 2 1 | 10 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | Hyperplasia | 1 2 | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 MG/KG | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| | L | | 3| 7| 1| 3| 5| 2| 1| 2| 4| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + M + M + + + + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Hyperplasia | 1 2 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 | 9 1.1| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Degeneration | 1 2 | 2 1.5| Mineralization | 2 1 1 1 1 1 1 | 7 1.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | M + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 1 | 1 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Epidermis, Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 30 MG/KG | 0| 1| 2| 3| 3| 4| 5| 5| 5| 6| | L | | 3| 7| 1| 3| 5| 2| 1| 2| 4| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 9 | Inflammation, Chronic Active | 1 1 1 | 3 1.0| Mineralization | 1 1 1 1 1 1 | 6 1.0| Vacuolization Cytoplasmic | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 2 3 2 2 2 1 2 3 2 | 9 2.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | A | 150 | 7| 9| 0| 0| 0| 2| 3| 3| 4| 5| | L | MG/KG | 8| 6| 1| 3| 7| 0| 1| 2| 5| 4| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X X X X X X X X | 8 | Clear Cell Focus | X X | 2 | Hepatodiaphragmatic Nodule | X | 1 | Mixed Cell Focus | X X X | 3 | Centrilobular, Vacuolization | | | Cytoplasmic | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Myocardium, Degeneration, Chronic | 2 1 1 1 1 2 1 1 1 1 | 10 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | Pigmentation, Hemosiderin | 1 | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + | 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + | 9 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | C-Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | A | 150 | 7| 9| 0| 0| 0| 2| 3| 3| 4| 5| | L | MG/KG | 8| 6| 1| 3| 7| 0| 1| 2| 5| 4| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Degeneration | 1 1 2 | 3 1.3| Mineralization | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Dilatation | 2 1 1 2 1 2 1 | 7 1.4| Lobular, Hyperplasia | 2 1 2 1 1 2 | 6 1.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Mineralization | 1 1 1 | 3 1.0| Vacuolization Cytoplasmic | 1 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 88032-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:09:28 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | A | 150 | 7| 9| 0| 0| 0| 2| 3| 3| 4| 5| | L | MG/KG | 8| 6| 1| 3| 7| 0| 1| 2| 5| 4| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 1 1 | 4 1.0| Nephropathy | 2 2 1 1 2 3 2 2 2 1 | 10 1.8| Pigmentation, Hemosiderin | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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