TDMS Study 88032-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus OXYMETHOLONE DATE: 11/24/97
EXPERIMENT: 88032 TEST: 05 TIME: 11:16:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-05295 ROUTE: GAVAGE NTP C#: 88032B
PATHOLOGIST: YARRINGTON, J. CAS: 434-07-01
------------------------------------------------------------------------------------------------------------------------------------
79 WEEK SSAC
REASONS FOR REMOVAL: 25017 Scheduled Sacrifice
REMOVAL DATE RANGE: 102094 102194
TREATMENT GROUPS: INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 3 MG/KG
INCLUDE 004 3 MG/KG
INCLUDE 005 30 MG/KG
INCLUDE 006 30 MG/KG
INCLUDE 007 150 MG/KG
INCLUDE 008 100 MG/KG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus OXYMETHOLONE DATE: 11/24/97
EXPERIMENT: 88032 TEST: 05 TIME: 11:16:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-05295 ROUTE: GAVAGE NTP C#: 88032B
PATHOLOGIST: YARRINGTON, J. CAS: 434-07-01
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF OXYMETHOLONE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Vacuolization Cytoplasmic
Kidney Mineralization
Liver Basophilic Focus
Hyperplasia
Inflammation Chronic
Mixed Cell Focus
Lung Inflammation Chronic
Mineralization
Mammary Gland Dilatation
Hyperplasia
Testes Hyperplasia
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Vacuolization Cytoplasmic
Clitoral Gland Cyst
Intestine Large, Rectum Parasite Metazoan
Kidney Nephropathy
Liver Clear Cell Focus
Inflammation Chronic
Vacuolization Cytoplasmic
Mammary Gland Dilatation
Hyperplasia
Ovary DYSGENESIS
====================================================================================================
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 1
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 3/10 (30%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 30.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 3/10 (30%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 548 (I) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.206N P=0.111 (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.206N P=0.111 (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.206N P=0.111 (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.203N |
|FISHER EXACT | (e) (e) (e) | P=0.105 (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/10 (40%) 8/10 (80%) 10/10 (100%) 10/10 (100%)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 9/10 (90%) |
|ADJUSTED (b) | 40.0% 80.0% 100.0% 100.0% | 0.0% 0.0% 10.0% 90.0% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 8/10 (80%) 10/10 (100%) 10/10 (100%)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 9/10 (90%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | --- --- 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028 * P=0.091 P=0.009 ** P=0.009 ** | P<0.001 ** (e) P=0.500 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.028 * P=0.091 P=0.009 ** P=0.009 ** | P<0.001 ** (e) P=0.500 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.028 * P=0.091 P=0.009 ** P=0.009 ** | P<0.001 ** (e) P=0.500 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.027 * | P<0.001 ** |
|FISHER EXACT | P=0.085 P=0.005 ** P=0.005 ** | (e) P=0.500 P<0.001 ** |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 2
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/10 (30%) 1/10 (10%) 2/10 (20%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|ADJUSTED (b) | 30.0% 10.0% 20.0% 0.0% | 0.0% 0.0% 10.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 1/10 (10%) 2/10 (20%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) --- | --- --- 548 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140N P=0.293N P=0.500N P=0.111N | P=0.785N (e) P=0.500 (e) |
|INCIDENTAL TUMOR | P=0.140N P=0.293N P=0.500N P=0.111N | P=0.785N (e) P=0.500 (e) |
|LOGISTIC REGRESSION | P=0.140N P=0.293N P=0.500N P=0.111N | P=0.785N (e) P=0.500 (e) |
|COCHRAN-ARMITAGE | P=0.137N | P=0.788N |
|FISHER EXACT | P=0.291N P=0.500N P=0.105N | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) | 0/9 (0%) 0/10 (0%) 0/8 (0%) 3/10 (30%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 30.0% |
|INTERIM SACRIFICE 1 (c)| 0/0 0/0 0/0 0/0 | 0/9 (0%) 0/10 (0%) 0/8 (0%) 3/10 (30%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.010 * (e) (e) P=0.129 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.010 * (e) (e) P=0.129 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.010 * (e) (e) P=0.129 |
|COCHRAN-ARMITAGE | (e) | P=0.009 ** |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.124 |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 3
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) | 5/9 (56%) 3/10 (30%) 2/8 (25%) 4/10 (40%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 55.6% 30.0% 25.0% 40.0% |
|INTERIM SACRIFICE 1 (c)| 0/0 0/0 0/0 0/0 | 5/9 (56%) 3/10 (30%) 2/8 (25%) 4/10 (40%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.575N P=0.260N P=0.223N P=0.416N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.575N P=0.260N P=0.223N P=0.416N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.575N P=0.260N P=0.223N P=0.416N |
|COCHRAN-ARMITAGE | (e) | P=0.576N |
|FISHER EXACT | (e) (e) (e) | P=0.255N P=0.218N P=0.414N |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Degeneration Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%)| 6/10 (60%) 7/10 (70%) 8/10 (80%) 9/10 (90%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 60.0% 70.0% 80.0% 90.0% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%)| 6/10 (60%) 7/10 (70%) 8/10 (80%) 9/10 (90%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.125 P=0.500 P=0.317 P=0.157 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.125 P=0.500 P=0.317 P=0.157 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.125 P=0.500 P=0.317 P=0.157 |
|COCHRAN-ARMITAGE | (e) | P=0.122 |
|FISHER EXACT | P=1.000N P=1.000N P=1.000N | P=0.500 P=0.314 P=0.152 |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 4
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 4/10 (40%) 1/10 (10%) 1/10 (10%) | 4/10 (40%) 4/10 (40%) 4/10 (40%) 0/10 (0%) |
|ADJUSTED (b) | 20.0% 40.0% 10.0% 10.0% | 40.0% 40.0% 40.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 4/10 (40%) 1/10 (10%) 1/10 (10%) | 4/10 (40%) 4/10 (40%) 4/10 (40%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) 548 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.234N P=0.317 P=0.500N P=0.500N | P=0.025N* P=0.672 P=0.672 P=0.051N |
|INCIDENTAL TUMOR | P=0.234N P=0.317 P=0.500N P=0.500N | P=0.025N* P=0.672 P=0.672 P=0.051N |
|LOGISTIC REGRESSION | P=0.234N P=0.317 P=0.500N P=0.500N | P=0.025N* P=0.672 P=0.672 P=0.051N |
|COCHRAN-ARMITAGE | P=0.231N | P=0.023N* |
|FISHER EXACT | P=0.314 P=0.500N P=0.500N | P=0.675N P=0.675N P=0.043N* |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 4/10 (40%) | 8/10 (80%) 9/10 (90%) 10/10 (100%) 9/10 (90%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 40.0% | 80.0% 90.0% 100.0% 90.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 4/10 (40%) | 8/10 (80%) 9/10 (90%) 10/10 (100%) 9/10 (90%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 548 (I) | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** (e) (e) P=0.051 | P=0.526 P=0.500 P=0.234 P=0.500 |
|INCIDENTAL TUMOR | P=0.001 ** (e) (e) P=0.051 | P=0.526 P=0.500 P=0.234 P=0.500 |
|LOGISTIC REGRESSION | P=0.001 ** (e) (e) P=0.051 | P=0.526 P=0.500 P=0.234 P=0.500 |
|COCHRAN-ARMITAGE | P=0.001 ** | P=0.526 |
|FISHER EXACT | (e) (e) P=0.043 * | P=0.500 P=0.237 P=0.500 |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 5
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/10 (100%) 10/10 (100%) 9/10 (90%) 10/10 (100%)| 8/10 (80%) 4/10 (40%) 9/10 (90%) 10/10 (100%)|
|ADJUSTED (b) | 100.0% 100.0% 90.0% 100.0% | 80.0% 40.0% 90.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 10/10 (100%) 9/10 (90%) 10/10 (100%)| 8/10 (80%) 4/10 (40%) 9/10 (90%) 10/10 (100%)|
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.765 (e) P=0.500N (e) | P=0.022 * P=0.091N P=0.500 P=0.234 |
|INCIDENTAL TUMOR | P=0.765 (e) P=0.500N (e) | P=0.022 * P=0.091N P=0.500 P=0.234 |
|LOGISTIC REGRESSION | P=0.765 (e) P=0.500N (e) | P=0.022 * P=0.091N P=0.500 P=0.234 |
|COCHRAN-ARMITAGE | P=0.768 | P=0.021 * |
|FISHER EXACT | P=1.000N P=0.500N P=1.000N | P=0.085N P=0.500 P=0.237 |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/10 (40%) 8/10 (80%) 9/10 (90%) 8/10 (80%) | 7/10 (70%) 10/10 (100%) 10/10 (100%) 9/10 (90%) |
|ADJUSTED (b) | 40.0% 80.0% 90.0% 80.0% | 70.0% 100.0% 100.0% 90.0% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 8/10 (80%) 9/10 (90%) 8/10 (80%) | 7/10 (70%) 10/10 (100%) 10/10 (100%) 9/10 (90%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.270 P=0.091 P=0.034 * P=0.091 | P=0.510 P=0.111 P=0.111 P=0.293 |
|INCIDENTAL TUMOR | P=0.270 P=0.091 P=0.034 * P=0.091 | P=0.510 P=0.111 P=0.111 P=0.293 |
|LOGISTIC REGRESSION | P=0.270 P=0.091 P=0.034 * P=0.091 | P=0.510 P=0.111 P=0.111 P=0.293 |
|COCHRAN-ARMITAGE | P=0.268 | P=0.510 |
|FISHER EXACT | P=0.085 P=0.029 * P=0.085 | P=0.105 P=0.105 P=0.291 |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 6
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 0/10 (0%) 2/10 (20%) 2/10 (20%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 3/10 (30%) |
|ADJUSTED (b) | 20.0% 0.0% 20.0% 20.0% | 0.0% 10.0% 0.0% 30.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 0/10 (0%) 2/10 (20%) 2/10 (20%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 3/10 (30%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) --- 548 (I) 548 (I) | --- 548 (I) --- 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.428 P=0.234N P=0.707 P=0.707 | P=0.041 * P=0.500 (e) P=0.111 |
|INCIDENTAL TUMOR | P=0.428 P=0.234N P=0.707 P=0.707 | P=0.041 * P=0.500 (e) P=0.111 |
|LOGISTIC REGRESSION | P=0.428 P=0.234N P=0.707 P=0.707 | P=0.041 * P=0.500 (e) P=0.111 |
|COCHRAN-ARMITAGE | P=0.427 | P=0.039 * |
|FISHER EXACT | P=0.237N P=0.709N P=0.709N | P=0.500 (e) P=0.105 |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 2/10 (20%) 1/10 (10%) 1/10 (10%) | 2/10 (20%) 1/10 (10%) 2/10 (20%) 1/10 (10%) |
|ADJUSTED (b) | 0.0% 20.0% 10.0% 10.0% | 20.0% 10.0% 20.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 1/10 (10%) 1/10 (10%) | 2/10 (20%) 1/10 (10%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.686 P=0.234 P=0.500 P=0.500 | P=0.493N P=0.500N P=0.707 P=0.500N |
|INCIDENTAL TUMOR | P=0.686 P=0.234 P=0.500 P=0.500 | P=0.494N P=0.500N P=0.707 P=0.500N |
|LOGISTIC REGRESSION | P=0.686 P=0.234 P=0.500 P=0.500 | P=0.494N P=0.500N P=0.707 P=0.500N |
|COCHRAN-ARMITAGE | P=0.688 | P=0.493N |
|FISHER EXACT | P=0.237 P=0.500 P=0.500 | P=0.500N P=0.709N P=0.500N |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 7
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/10 (80%) 5/10 (50%) 1/10 (10%) 0/10 (0%) | 7/10 (70%) 6/10 (60%) 7/10 (70%) 1/10 (10%) |
|ADJUSTED (b) | 80.0% 50.0% 10.0% 0.0% | 70.0% 60.0% 70.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 8/10 (80%) 5/10 (50%) 1/10 (10%) 0/10 (0%) | 7/10 (70%) 6/10 (60%) 7/10 (70%) 1/10 (10%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) --- | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** P=0.180N P=0.004N** P<0.001N** | P=0.005N** P=0.500N P=0.683 P=0.013N* |
|INCIDENTAL TUMOR | P=0.002N** P=0.180N P=0.004N** P<0.001N** | P=0.005N** P=0.500N P=0.683 P=0.013N* |
|LOGISTIC REGRESSION | P=0.002N** P=0.180N P=0.004N** P<0.001N** | P=0.005N** P=0.500N P=0.683 P=0.013N* |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.004N** |
|FISHER EXACT | P=0.175N P=0.003N** P<0.001N** | P=0.500N P=0.686N P=0.010N** |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 3/10 (30%) | 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|ADJUSTED (b) | 0.0% 10.0% 0.0% 30.0% | 0.0% 0.0% 20.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 3/10 (30%) | 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- 548 (I) --- 548 (I) | --- --- 548 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.037 * P=0.500 (e) P=0.111 | P=0.694N (e) P=0.234 (e) |
|INCIDENTAL TUMOR | P=0.037 * P=0.500 (e) P=0.111 | P=0.694N (e) P=0.234 (e) |
|LOGISTIC REGRESSION | P=0.037 * P=0.500 (e) P=0.111 | P=0.694N (e) P=0.234 (e) |
|COCHRAN-ARMITAGE | P=0.036 * | P=0.696N |
|FISHER EXACT | P=0.500 (e) P=0.105 | (e) P=0.237 (e) |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 8
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/10 (100%) 6/10 (60%) 6/10 (60%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|ADJUSTED (b) | 100.0% 60.0% 60.0% 0.0% | 0.0% 0.0% 0.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 6/10 (60%) 6/10 (60%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) --- | --- --- --- 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.051N P=0.051N P<0.001N** | P=0.215 (e) (e) P=0.500 |
|INCIDENTAL TUMOR | P<0.001N** P=0.051N P=0.051N P<0.001N** | P=0.215 (e) (e) P=0.500 |
|LOGISTIC REGRESSION | P<0.001N** P=0.051N P=0.051N P<0.001N** | P=0.215 (e) (e) P=0.500 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.212 |
|FISHER EXACT | P=0.043N* P=0.043N* P<0.001N** | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Vacuolization Cytoplasmic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/10 (30%) 5/10 (50%) 2/10 (20%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 9/10 (90%) 1/10 (10%) |
|ADJUSTED (b) | 30.0% 50.0% 20.0% 10.0% | 0.0% 0.0% 90.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 5/10 (50%) 2/10 (20%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 9/10 (90%) 1/10 (10%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | --- --- 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107N P=0.328 P=0.500N P=0.293N | P=0.491 (e) P<0.001 ** P=0.500 |
|INCIDENTAL TUMOR | P=0.107N P=0.328 P=0.500N P=0.293N | P=0.491 (e) P<0.001 ** P=0.500 |
|LOGISTIC REGRESSION | P=0.107N P=0.328 P=0.500N P=0.293N | P=0.491 (e) P<0.001 ** P=0.500 |
|COCHRAN-ARMITAGE | P=0.104N | P=0.491 |
|FISHER EXACT | P=0.325 P=0.500N P=0.291N | (e) P<0.001 ** P=0.500 |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 9
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 4/10 (40%) 3/9 (33%) 0/10 (0%) | 1/10 (10%) 4/10 (40%) 4/10 (40%) 3/10 (30%) |
|ADJUSTED (b) | 0.0% 40.0% 33.3% 0.0% | 10.0% 40.0% 40.0% 30.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 4/10 (40%) 3/9 (33%) 0/10 (0%) | 1/10 (10%) 4/10 (40%) 4/10 (40%) 3/10 (30%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- 548 (I) 548 (I) --- | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142N P=0.051 P=0.093 (e) | P=0.507 P=0.157 P=0.157 P=0.293 |
|INCIDENTAL TUMOR | P=0.142N P=0.051 P=0.093 (e) | P=0.507 P=0.157 P=0.157 P=0.293 |
|LOGISTIC REGRESSION | P=0.142N P=0.051 P=0.093 (e) | P=0.507 P=0.157 P=0.157 P=0.293 |
|COCHRAN-ARMITAGE | P=0.139N | P=0.507 |
|FISHER EXACT | P=0.043 * P=0.087 (e) | P=0.152 P=0.152 P=0.291 |
|=================================================================================================================================|
| |
|Lung |
| Mineralization |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/10 (10%) 4/10 (40%) 6/9 (67%) 3/10 (30%) | 2/10 (20%) 1/10 (10%) 5/10 (50%) 3/10 (30%) |
|ADJUSTED (b) | 10.0% 40.0% 66.7% 30.0% | 20.0% 10.0% 50.0% 30.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 4/10 (40%) 6/9 (67%) 3/10 (30%) | 2/10 (20%) 1/10 (10%) 5/10 (50%) 3/10 (30%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.617N P=0.157 P=0.021 * P=0.293 | P=0.325 P=0.500N P=0.180 P=0.500 |
|INCIDENTAL TUMOR | P=0.617N P=0.157 P=0.021 * P=0.293 | P=0.325 P=0.500N P=0.180 P=0.500 |
|LOGISTIC REGRESSION | P=0.617N P=0.157 P=0.021 * P=0.293 | P=0.325 P=0.500N P=0.180 P=0.500 |
|COCHRAN-ARMITAGE | P=0.618N | P=0.323 |
|FISHER EXACT | P=0.152 P=0.017 * P=0.291 | P=0.500N P=0.175 P=0.500 |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 10
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Vacuolization Cytoplasmic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/10 (10%) 3/10 (30%) 1/9 (11%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 10.0% 30.0% 11.1% 20.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 3/10 (30%) 1/9 (11%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.615 P=0.293 P=0.743 P=0.500 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.615 P=0.293 P=0.743 P=0.500 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.615 P=0.293 P=0.743 P=0.500 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.617 | (e) |
|FISHER EXACT | P=0.291 P=0.737 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Dilatation |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 3/10 (30%) 1/10 (10%) 7/10 (70%) | 4/10 (40%) 1/10 (10%) 0/10 (0%) 1/10 (10%) |
|ADJUSTED (b) | 20.0% 30.0% 10.0% 70.0% | 40.0% 10.0% 0.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 3/10 (30%) 1/10 (10%) 7/10 (70%) | 4/10 (40%) 1/10 (10%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) --- 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.500 P=0.500N P=0.040 * | P=0.252N P=0.157N P=0.051N P=0.157N |
|INCIDENTAL TUMOR | P=0.009 ** P=0.500 P=0.500N P=0.040 * | P=0.252N P=0.157N P=0.051N P=0.157N |
|LOGISTIC REGRESSION | P=0.009 ** P=0.500 P=0.500N P=0.040 * | P=0.252N P=0.157N P=0.051N P=0.157N |
|COCHRAN-ARMITAGE | P=0.008 ** | P=0.249N |
|FISHER EXACT | P=0.500 P=0.500N P=0.035 * | P=0.152N P=0.043N* P=0.152N |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 11
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Galactocele |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 20.0% 10.0% 0.0% 0.0% | 10.0% 10.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) --- --- | 548 (I) 548 (I) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236N P=0.500N P=0.234N P=0.234N | P=0.306N P=0.766 P=0.500N P=0.500N |
|INCIDENTAL TUMOR | P=0.236N P=0.500N P=0.234N P=0.234N | P=0.306N P=0.766 P=0.500N P=0.500N |
|LOGISTIC REGRESSION | P=0.236N P=0.500N P=0.234N P=0.234N | P=0.306N P=0.766 P=0.500N P=0.500N |
|COCHRAN-ARMITAGE | P=0.234N | P=0.304N |
|FISHER EXACT | P=0.500N P=0.237N P=0.237N | P=0.763N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland: Lobular |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 6/10 (60%) | 1/10 (10%) 0/10 (0%) 9/10 (90%) 9/10 (90%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 60.0% | 10.0% 0.0% 90.0% 90.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 6/10 (60%) | 1/10 (10%) 0/10 (0%) 9/10 (90%) 9/10 (90%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 548 (I) | 548 (I) --- 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.009 ** | P<0.001 ** P=0.500N P=0.001 ** P=0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** (e) (e) P=0.009 ** | P<0.001 ** P=0.500N P=0.001 ** P=0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** (e) (e) P=0.009 ** | P<0.001 ** P=0.500N P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | (e) (e) P=0.005 ** | P=0.500N P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 12
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/3 (67%) 1/1 (100%) 3/3 (100%) 0/0 (0%) | 4/4 (100%) 3/3 (100%) 2/2 (100%) 1/1 (100%) |
|ADJUSTED (b) | 66.7% 100.0% 100.0% 0.0% | 100.0% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 2/3 (67%) 1/1 (100%) 3/3 (100%) 0/0 | 4/4 (100%) 3/3 (100%) 2/2 (100%) 1/1 (100%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) --- | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.999 P=0.718 P=0.500 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.999 P=0.718 P=0.500 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.999 P=0.718 P=0.500 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=1.000 | (e) |
|FISHER EXACT | P=0.750 P=0.500 P=1.000N | P=1.000N P=1.000N P=1.000N |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/10 (10%) 2/10 (20%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|ADJUSTED (b) | 10.0% 20.0% 10.0% 0.0% | 0.0% 0.0% 10.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/10 (20%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) --- | --- --- 548 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.230N P=0.500 P=0.766 P=0.500N | P=0.785N (e) P=0.500 (e) |
|INCIDENTAL TUMOR | P=0.230N P=0.500 P=0.766 P=0.500N | P=0.785N (e) P=0.500 (e) |
|LOGISTIC REGRESSION | P=0.230N P=0.500 P=0.766 P=0.500N | P=0.785N (e) P=0.500 (e) |
|COCHRAN-ARMITAGE | P=0.227N | P=0.788N |
|FISHER EXACT | P=0.500 P=0.763N P=0.500N | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 13
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| DYSGENESIS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | | 0/10 (0%) 0/10 (0%) 8/10 (80%) 10/10 (100%)|
|ADJUSTED (b) | | 0.0% 0.0% 80.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 8/10 (80%) 10/10 (100%)|
|TERMINAL (d) | | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | --- --- 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P<0.001 ** (e) P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | | P<0.001 ** (e) P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | | P<0.001 ** (e) P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | | P<0.001 ** |
|FISHER EXACT | | (e) P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Ovary: Periovarian Tissue |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | | 3/10 (30%) 1/10 (10%) 1/10 (10%) 1/10 (10%) |
|ADJUSTED (b) | | 30.0% 10.0% 10.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| | 3/10 (30%) 1/10 (10%) 1/10 (10%) 1/10 (10%) |
|TERMINAL (d) | | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.366N P=0.293N P=0.293N P=0.293N |
|INCIDENTAL TUMOR | | P=0.366N P=0.293N P=0.293N P=0.293N |
|LOGISTIC REGRESSION | | P=0.366N P=0.293N P=0.293N P=0.293N |
|COCHRAN-ARMITAGE | | P=0.365N |
|FISHER EXACT | | P=0.291N P=0.291N P=0.291N |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 14
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/10 (10%) 2/10 (20%) 2/10 (20%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|ADJUSTED (b) | 10.0% 20.0% 20.0% 0.0% | 10.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 2/10 (20%) 2/10 (20%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) --- | 548 (I) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.214N P=0.500 P=0.500 P=0.500N | P=0.517N P=0.500N P=0.500N P=0.500N |
|INCIDENTAL TUMOR | P=0.214N P=0.500 P=0.500 P=0.500N | P=0.517N P=0.500N P=0.500N P=0.500N |
|LOGISTIC REGRESSION | P=0.214N P=0.500 P=0.500 P=0.500N | P=0.517N P=0.500N P=0.500N P=0.500N |
|COCHRAN-ARMITAGE | P=0.212N | P=0.518N |
|FISHER EXACT | P=0.500 P=0.500 P=0.500N | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 2/10 (20%) 1/9 (11%) 2/10 (20%) 1/10 (10%) |
|ADJUSTED (b) | 20.0% 0.0% 0.0% 0.0% | 20.0% 11.1% 20.0% 10.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 2/10 (20%) 1/9 (11%) 2/10 (20%) 1/10 (10%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) --- --- --- | 548 (I) 548 (I) 548 (I) 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.377N P=0.234N P=0.234N P=0.257N | P=0.473N P=0.539N P=0.707 P=0.500N |
|INCIDENTAL TUMOR | P=0.377N P=0.234N P=0.234N P=0.257N | P=0.473N P=0.539N P=0.707 P=0.500N |
|LOGISTIC REGRESSION | P=0.377N P=0.234N P=0.234N P=0.257N | P=0.473N P=0.539N P=0.707 P=0.500N |
|COCHRAN-ARMITAGE | P=0.375N | P=0.473N |
|FISHER EXACT | P=0.237N P=0.237N P=0.263N | P=0.542N P=0.709N P=0.500N |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 15
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 3/10 (30%) 2/10 (20%) 1/9 (11%) | 1/10 (10%) 1/9 (11%) 0/10 (0%) 2/10 (20%) |
|ADJUSTED (b) | 20.0% 30.0% 20.0% 11.1% | 10.0% 11.1% 0.0% 20.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 3/10 (30%) 2/10 (20%) 1/9 (11%) | 1/10 (10%) 1/9 (11%) 0/10 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | 548 (I) 548 (I) --- 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.334N P=0.500 P=0.707 P=0.539N | P=0.341 P=0.743 P=0.500N P=0.500 |
|INCIDENTAL TUMOR | P=0.334N P=0.500 P=0.707 P=0.539N | P=0.341 P=0.743 P=0.500N P=0.500 |
|LOGISTIC REGRESSION | P=0.334N P=0.500 P=0.707 P=0.539N | P=0.341 P=0.743 P=0.500N P=0.500 |
|COCHRAN-ARMITAGE | P=0.332N | P=0.339 |
|FISHER EXACT | P=0.500 P=0.709N P=0.542N | P=0.737 P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/10 (100%) 8/10 (80%) 9/10 (90%) 8/10 (80%) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|ADJUSTED (b) | 100.0% 80.0% 90.0% 80.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 8/10 (80%) 9/10 (90%) 8/10 (80%) | 0/0 0/0 0/0 0/0 |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.358N P=0.234N P=0.500N P=0.234N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.358N P=0.234N P=0.500N P=0.234N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.358N P=0.234N P=0.500N P=0.234N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.356N | (e) |
|FISHER EXACT | P=0.237N P=0.500N P=0.237N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 16
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 2/10 (20%) 0/10 (0%) 0/10 (0%) | |
|ADJUSTED (b) | 20.0% 20.0% 0.0% 0.0% | |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 2/10 (20%) 0/10 (0%) 0/10 (0%) | |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) --- --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.707 P=0.234N P=0.234N | |
|INCIDENTAL TUMOR | P=0.160N P=0.707 P=0.234N P=0.234N | |
|LOGISTIC REGRESSION | P=0.160N P=0.707 P=0.234N P=0.234N | |
|COCHRAN-ARMITAGE | P=0.157N | |
|FISHER EXACT | P=0.709N P=0.237N P=0.237N | |
|=================================================================================================================================|
| |
|Testes |
| Degeneration |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 1/10 (10%) 2/10 (20%) 3/10 (30%) | |
|ADJUSTED (b) | 20.0% 10.0% 20.0% 30.0% | |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 2/10 (20%) 3/10 (30%) | |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.290 P=0.500N P=0.707 P=0.500 | |
|INCIDENTAL TUMOR | P=0.290 P=0.500N P=0.707 P=0.500 | |
|LOGISTIC REGRESSION | P=0.290 P=0.500N P=0.707 P=0.500 | |
|COCHRAN-ARMITAGE | P=0.287 | |
|FISHER EXACT | P=0.500N P=0.709N P=0.500 | |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 17
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Mineralization |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/10 (30%) 1/10 (10%) 7/10 (70%) 4/10 (40%) | |
|ADJUSTED (b) | 30.0% 10.0% 70.0% 40.0% | |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 1/10 (10%) 7/10 (70%) 4/10 (40%) | |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) 548 (I) 548 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.363 P=0.293N P=0.095 P=0.500 | |
|INCIDENTAL TUMOR | P=0.363 P=0.293N P=0.095 P=0.500 | |
|LOGISTIC REGRESSION | P=0.363 P=0.293N P=0.090 P=0.500 | |
|COCHRAN-ARMITAGE | P=0.361 | |
|FISHER EXACT | P=0.291N P=0.089 P=0.500 | |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/10 (30%) 4/10 (40%) 0/10 (0%) 0/10 (0%) | |
|ADJUSTED (b) | 30.0% 40.0% 0.0% 0.0% | |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 4/10 (40%) 0/10 (0%) 0/10 (0%) | |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | |
|FIRST INCIDENCE (DAYS) | 548 (I) 548 (I) --- --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.048N* P=0.500 P=0.111N P=0.111N | |
|INCIDENTAL TUMOR | P=0.048N* P=0.500 P=0.111N P=0.111N | |
|LOGISTIC REGRESSION | P=0.048N* P=0.500 P=0.111N P=0.111N | |
|COCHRAN-ARMITAGE | P=0.046N* | |
|FISHER EXACT | P=0.500 P=0.105N P=0.105N | |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 18
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/9 (0%) |
|ADJUSTED (b) | 20.0% 0.0% 0.0% 10.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 548 (I) --- --- 548 (I) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.678 P=0.234N P=0.257N P=0.500N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.678 P=0.234N P=0.257N P=0.500N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.678 P=0.234N P=0.257N P=0.500N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.681 | (e) |
|FISHER EXACT | P=0.237N P=0.263N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 10.0% | 10.0% 0.0% 20.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|TERMINAL (d) | 0/0 0/0 0/0 0/0 | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 548 (I) | 548 (I) --- 548 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.235 (e) (e) P=0.500 | P=0.472N P=0.500N P=0.500 P=0.500N |
|INCIDENTAL TUMOR | P=0.235 (e) (e) P=0.500 | P=0.472N P=0.500N P=0.500 P=0.500N |
|LOGISTIC REGRESSION | P=0.235 (e) (e) P=0.500 | P=0.472N P=0.500N P=0.500 P=0.500N |
|COCHRAN-ARMITAGE | P=0.232 | P=0.472N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 11/24/97 EXPERIMENT: 88032 TEST: 05 PAGE 19
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- OXYMETHOLONE
TERMINAL SACRIFICE AT . WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 30 MG/KG 150 | 0 MG/KG 3 MG/KG 30 MG/KG 100 |
| | MG/KG | MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | | 3/10 (30%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|ADJUSTED (b) | | 30.0% 0.0% 0.0% 20.0% |
|INTERIM SACRIFICE 1 (c)| | 3/10 (30%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|TERMINAL (d) | | 0/0 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | 548 (I) --- --- 548 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.506 P=0.111N P=0.111N P=0.500N |
|INCIDENTAL TUMOR | | P=0.506 P=0.111N P=0.111N P=0.500N |
|LOGISTIC REGRESSION | | P=0.506 P=0.111N P=0.111N P=0.500N |
|COCHRAN-ARMITAGE | | P=0.506 |
|FISHER EXACT | | P=0.105N P=0.105N P=0.500N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 548
Female interim sacrifices(days): 548
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).