TDMS Study 88034-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) OZONE NTP Experiment-Test: 88034-04 Report: PEIRPT03 Study Type: CHRONIC Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 15 10 9 9 Natural Death 6 3 6 1 Accidently Killed 2 Survivors Terminal Sacrifice 29 37 33 40 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (50) (47) (46) (50) Inflammation, Chronic Active 1 (2%) Intestine Small, Duodenum (47) (48) (45) (49) Inflammation, Acute 1 (2%) Necrosis 1 (2%) Intestine Small, Jejunum (50) (47) (46) (49) Hyperplasia, Lymphoid 1 (2%) Inflammation, Chronic Active 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) 1 (2%) 1 (2%) Basophilic Focus 1 (2%) 2 (4%) 2 (4%) Clear Cell Focus 1 (2%) 1 (2%) 2 (4%) Cyst 1 (2%) Degeneration, Fatty 1 (2%) 1 (2%) Eosinophilic Focus 3 (6%) 3 (6%) 5 (10%) 4 (8%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) Necrosis 1 (2%) 2 (4%) 1 (2%) Centrilobular, Necrosis 1 (2%) Mesentery (11) (4) (4) (1) Artery, Inflammation, Chronic Active 1 (9%) Fat, Inflammation, Chronic 1 (25%) Fat, Necrosis 7 (64%) 3 (75%) 3 (75%) Pancreas (49) (50) (48) (50) Atrophy 1 (2%) 2 (4%) 1 (2%) Basophilic Focus 1 (2%) Cyst 1 (2%) Hypertrophy 1 (2%) 1 (2%) Lipomatosis 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) Salivary Glands (50) (49) (49) (50) Degeneration, Fatty 1 (2%) Stomach, Forestomach (50) (50) (48) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Diverticulum 1 (2%) Hyperplasia, Squamous 1 (2%) 3 (6%) Inflammation, Acute 1 (2%) 5 (10%) Mineralization 1 (2%) Necrosis 1 (2%) Stomach, Glandular (50) (50) (48) (50) Mineralization 2 (4%) 8 (16%) 6 (13%) 3 (6%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 6 (12%) 8 (16%) 5 (10%) 5 (10%) Mineralization 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) Atrium, Thrombosis 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (49) (50) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 1 (2%) 4 (8%) 7 (14%) 3 (6%) Hypertrophy 1 (2%) 4 (8%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) Adrenal Medulla (50) (50) (49) (50) Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%) Islets, Pancreatic (49) (50) (48) (50) Hyperplasia 1 (2%) 1 (2%) Pituitary Gland (50) (50) (47) (49) Cyst 1 (2%) Pars Distalis, Hyperplasia 11 (22%) 14 (28%) 20 (43%) 17 (35%) Pars Intermedia, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%) Thyroid Gland (50) (50) (49) (50) Follicular Cell, Hyperplasia 8 (16%) 19 (38%) 21 (43%) 25 (50%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (50) (48) (50) Angiectasis 2 (4%) 2 (4%) Cyst 11 (22%) 12 (24%) 13 (27%) 11 (22%) Hyperplasia, Tubular 1 (2%) Inflammation, Suppurative 1 (2%) Thrombosis 1 (2%) 1 (2%) Uterus (50) (50) (49) (50) Angiectasis 1 (2%) 2 (4%) 1 (2%) 2 (4%) Decidual Reaction 1 (2%) Hydrometra 4 (8%) 8 (16%) 3 (6%) 3 (6%) Inflammation, Suppurative 1 (2%) 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (50) Myelofibrosis 1 (2%) Lymph Node (9) (6) (3) (4) Iliac, Angiectasis 1 (11%) Iliac, Hematopoietic Cell Proliferation 1 (11%) Iliac, Hemorrhage 1 (11%) Iliac, Infiltration Cellular, Plasma Cell 1 (33%) Iliac, Infiltration Cellular, Histiocyte 1 (11%) Lumbar, Infiltration Cellular, Histiocyte 1 (11%) Renal, Hematopoietic Cell Proliferation 1 (11%) Lymph Node, Bronchial (48) (39) (40) (42) Infiltration Cellular, Plasma Cell 1 (3%) Lymph Node, Mandibular (47) (39) (43) (46) Hematopoietic Cell Proliferation 1 (2%) Infiltration Cellular, Histiocyte 1 (2%) Lymph Node, Mesenteric (49) (49) (46) (47) Angiectasis 1 (2%) 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 2 (4%) 1 (2%) Inflammation, Chronic Active 2 (4%) Lymph Node, Mediastinal (41) (42) (39) (35) Infiltration Cellular, Plasma Cell 1 (2%) Spleen (49) (50) (48) (50) Hematopoietic Cell Proliferation 11 (22%) 6 (12%) 10 (21%) 3 (6%) Hyperplasia, Lymphoid 2 (4%) 2 (4%) 2 (4%) Hyperplasia, Mast Cell 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (48) (49) Hyperplasia 1 (2%) Skin (50) (50) (49) (50) Prepuce, Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (49) (50) Necrosis 1 (2%) Meninges, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Spinal Cord (1) Inflammation, Chronic 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (49) (50) Inflammation, Chronic Active 2 (4%) 1 (2%) Epiglottis, Hyperplasia 7 (14%) Epiglottis, Metaplasia, Squamous 4 (8%) Lung (50) (50) (49) (50) Congestion, Chronic 1 (2%) 1 (2%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 1 (2%) 2 (4%) Alveolar Epithelium, Metaplasia 43 (88%) 49 (98%) Alveolus, Infiltration Cellular, Histiocyte 11 (22%) 42 (84%) Bronchiole, Hyperplasia 2 (4%) Bronchiole, Necrosis 1 (2%) Nose (50) (50) (48) (50) Glands, Hyperplasia 1 (2%) Lateral Wall, Degeneration, Hyaline 5 (10%) 18 (36%) 48 (100%) 50 (100%) Lateral Wall, Fibrosis 3 (6%) 46 (96%) 50 (100%) Lateral Wall, Hyperplasia 42 (88%) 50 (100%) Lateral Wall, Inflammation, Suppurative 5 (10%) 46 (96%) 50 (100%) Lateral Wall, Metaplasia, Squamous 1 (2%) 1 (2%) 11 (23%) 36 (72%) Olfactory Epithelium, Atrophy 4 (8%) 1 (2%) 14 (29%) 41 (82%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) Inflammation, Chronic Active 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Amyloid Deposition 1 (2%) Infarct 1 (2%) 1 (2%) 1 (2%) Nephropathy 25 (50%) 33 (66%) 29 (59%) 26 (52%) Renal Tubule, Necrosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 16 10 19 20 Natural Death 4 6 6 3 Survivors Terminal Sacrifice 29 34 25 27 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (46) (48) (48) Degeneration, Hyaline 1 (2%) Intestine Small, Duodenum (49) (47) (48) (48) Necrosis 1 (2%) Intestine Small, Ileum (49) (48) (49) (50) Inflammation, Chronic Active 1 (2%) Peyer's Patch, Infiltration Cellular, Plasma Cell 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) Basophilic Focus 2 (4%) Clear Cell Focus 4 (8%) 4 (8%) 2 (4%) 1 (2%) Cyst 1 (2%) Degeneration, Fatty 1 (2%) Eosinophilic Focus 1 (2%) 2 (4%) 2 (4%) Fibrosis 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Inflammation, Chronic Active 1 (2%) Karyomegaly 1 (2%) Mineralization 1 (2%) Necrosis 3 (6%) 1 (2%) 1 (2%) Centrilobular, Necrosis 1 (2%) 2 (4%) Mesentery (4) (5) (1) (3) Inflammation, Chronic Active 1 (20%) Fat, Necrosis 3 (75%) 3 (60%) 3 (100%) Pancreas (49) (50) (50) (50) Atrophy 1 (2%) 1 (2%) Basophilic Focus 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Angiectasis 1 (2%) Hyperplasia, Squamous 1 (2%) 1 (2%) Inflammation, Acute 3 (6%) 1 (2%) Necrosis 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Stomach, Glandular (50) (49) (50) (50) Inflammation, Acute 1 (2%) Tooth (1) (1) (1) (1) Developmental Malformation 1 (100%) Inflammation, Chronic Active 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 8 (16%) 18 (36%) 11 (22%) 17 (34%) Inflammation, Chronic Active 1 (2%) Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Atrophy 1 (2%) Hyperplasia 14 (28%) 9 (18%) 12 (24%) 15 (30%) Hypertrophy 26 (52%) 31 (62%) 22 (44%) 22 (44%) Capsule, Hyperplasia 3 (6%) 1 (2%) 1 (2%) Adrenal Medulla (50) (50) (50) (50) Hyperplasia 2 (4%) 2 (4%) 2 (4%) 3 (6%) Pituitary Gland (47) (49) (49) (48) Cyst 1 (2%) 1 (2%) 1 (2%) Pars Distalis, Hyperplasia 5 (11%) 2 (4%) 1 (2%) Thyroid Gland (49) (50) (50) (50) Inflammation, Chronic 2 (4%) Follicular Cell, Hyperplasia 6 (12%) 8 (16%) 10 (20%) 17 (34%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Granuloma Sperm 1 (2%) 2 (4%) 1 (2%) Penis (2) (1) Inflammation, Acute 1 (50%) 1 (100%) Preputial Gland (50) (50) (50) (50) Cyst 1 (2%) Hyperplasia 1 (2%) Inflammation, Chronic Active 12 (24%) 4 (8%) 6 (12%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Necrosis 1 (2%) Prostate (49) (50) (47) (49) Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%) Artery, Inflammation, Chronic Active 1 (2%) Seminal Vesicle (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Testes (50) (50) (50) (50) Atrophy 4 (8%) 2 (4%) 1 (2%) 4 (8%) Mineralization 1 (2%) 3 (6%) Interstitial Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Atrophy 1 (2%) Necrosis 1 (2%) Lymph Node (4) (6) (3) (10) Iliac, Infiltration Cellular, Plasma Cell 1 (25%) 1 (17%) 1 (33%) 7 (70%) Inguinal, Infiltration Cellular, Plasma Cell 1 (17%) Renal, Infiltration Cellular, Plasma Cell 1 (25%) 1 (10%) Lymph Node, Mesenteric (48) (49) (49) (49) Angiectasis 1 (2%) 1 (2%) Hemorrhage 2 (4%) Spleen (49) (50) (49) (50) Angiectasis 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 3 (6%) 6 (12%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Ulcer 1 (2%) Prepuce, Inflammation, Chronic Active 8 (16%) 6 (12%) 12 (24%) 20 (40%) Subcutaneous Tissue, Fibrosis 1 (2%) Subcutaneous Tissue, Inflammation, Granulomatous 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hemorrhage 1 (2%) Necrosis 1 (2%) Meninges, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) (50) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 4 (8%) 13 (26%) 4 (8%) 9 (18%) Artery, Inflammation, Chronic Active 1 (2%) Epiglottis, Hyperplasia 1 (2%) 6 (12%) Epiglottis, Metaplasia, Squamous 2 (4%) Lung (50) (50) (50) (50) Fibrosis 1 (2%) Hemorrhage 1 (2%) 1 (2%) 1 (2%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 4 (8%) 6 (12%) 2 (4%) 3 (6%) Alveolar Epithelium, Metaplasia 48 (96%) 50 (100%) Alveolus, Infiltration Cellular, Histiocyte 18 (36%) 31 (62%) Bronchiole, Erosion 1 (2%) Bronchiole, Hyperplasia 1 (2%) Bronchiole, Necrosis 3 (6%) Bronchus, Erosion 1 (2%) Bronchus, Necrosis 1 (2%) Nose (50) (50) (50) (50) Inflammation, Suppurative 2 (4%) Lateral Wall, Degeneration, Hyaline 2 (4%) 1 (2%) 49 (98%) 50 (100%) Lateral Wall, Fibrosis 47 (94%) 49 (98%) Lateral Wall, Hyperplasia 42 (84%) 50 (100%) Lateral Wall, Inflammation, Suppurative 8 (16%) 42 (84%) 50 (100%) Lateral Wall, Metaplasia, Squamous 3 (6%) 3 (6%) 36 (72%) Nasopharyngeal Duct, Inflammation, Chronic Active 1 (2%) Olfactory Epithelium, Atrophy 1 (2%) 3 (6%) 3 (6%) 11 (22%) Olfactory Epithelium, Metaplasia 1 (2%) Trachea (50) (50) (50) (50) Infiltration Cellular, Polymorphonuclear 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:29 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) Cataract 1 (100%) Harderian Gland (1) (8) (6) (4) Hyperplasia 1 (13%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Cyst 1 (2%) 1 (2%) 1 (2%) Infarct 3 (6%) 1 (2%) 1 (2%) 6 (12%) Metaplasia, Osseous 1 (2%) 4 (8%) Nephropathy 43 (86%) 40 (80%) 46 (92%) 37 (74%) Papilla, Inflammation, Suppurative 6 (12%) 3 (6%) 8 (16%) 14 (28%) Pelvis, Dilatation 3 (6%) 4 (8%) 4 (8%) 4 (8%) Urethra (3) Inflammation, Suppurative 1 (33%) Bulbourethral Gland, Inflammation, Suppurative 2 (67%) Urinary Bladder (50) (50) (50) (49) Inflammation, Chronic Active 6 (12%) 3 (6%) 8 (16%) 13 (27%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 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