TDMS Study 88034-04 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
OZONE
NTP Experiment-Test: 88034-04 Report: PEIRPT05
Study Type: CHRONIC Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 10 9 9
Natural Death 6 3 6 1
Accidently Killed 2
Survivors
Terminal Sacrifice 29 37 33 40
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (47) (46) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Intestine Large, Colon (50) (50) (47) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Intestine Large, Rectum (49) (43) (45) (45)
Intestine Large, Cecum (50) (50) (47) (50)
Intestine Small, Duodenum (47) (48) (45) (49)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (50) (47) (46) (49)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Intestine Small, Ileum (50) (49) (45) (50)
Liver (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 14 (28%) 4 (8%) 5 (10%) 3 (6%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%)
Hepatocellular Adenoma 13 (26%) 13 (26%) 12 (24%) 8 (16%)
Hepatocellular Adenoma, Multiple 7 (14%) 5 (10%) 5 (10%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (11) (4) (4) (1)
Carcinoma, Metastatic, Pancreas 1 (9%)
Hemangiosarcoma 1 (9%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (9%)
Pancreas (49) (50) (48) (50)
Carcinoma 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Salivary Glands (50) (49) (49) (50)
Stomach, Forestomach (50) (50) (48) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Page 2
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (48) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
Tooth (1) (1)
Histiocytic Sarcoma 1 (100%)
Odontoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Capsule, Adenoma 1 (2%)
Capsule, Carcinoma 1 (2%)
Adrenal Medulla (50) (50) (49) (50)
Pheochromocytoma Benign 2 (4%) 2 (4%) 3 (6%)
Islets, Pancreatic (49) (50) (48) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (47) (49)
Pars Distalis, Adenoma 17 (34%) 13 (26%) 14 (30%) 9 (18%)
Pars Intermedia, Adenoma 3 (6%) 2 (4%) 2 (4%)
Thyroid Gland (50) (50) (49) (50)
Follicular Cell, Adenoma 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Follicular Cell, Carcinoma 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (50) (48) (50)
Cystadenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Page 3
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (2%)
Teratoma Benign 1 (2%)
Bilateral, Cystadenoma 1 (2%)
Uterus (50) (50) (49) (50)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (2%)
Hemangiosarcoma 2 (4%) 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%) 5 (10%)
Sarcoma Stromal 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Hemangiosarcoma 1 (2%) 3 (6%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (9) (6) (3) (4)
Iliac, Histiocytic Sarcoma 1 (17%)
Pancreatic, Histiocytic Sarcoma 1 (17%)
Renal, Histiocytic Sarcoma 1 (17%)
Lymph Node, Bronchial (48) (39) (40) (42)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Lymph Node, Mandibular (47) (39) (43) (46)
Lymph Node, Mesenteric (49) (49) (46) (47)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (41) (42) (39) (35)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (49) (50) (48) (50)
Hemangiosarcoma 1 (2%) 1 (2%) 4 (8%) 2 (4%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Thymus (47) (49) (46) (47)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (48) (49)
Carcinoma 1 (2%) 1 (2%)
Skin (50) (50) (49) (50)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (100%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 5 (10%) 5 (10%) 7 (14%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 2 (4%) 5 (10%) 8 (16%)
Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (2%)
Hemangiosarcoma, Metastatic, Uterus 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 2 (4%) 2 (4%) 2 (4%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Mediastinum, Hemangiosarcoma 1 (2%)
Nose (50) (50) (48) (50)
Carcinoma, Metastatic, Harderian Gland 2 (4%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2) (4) (3)
Adenoma 1 (33%) 3 (75%) 1 (33%)
Carcinoma 2 (67%) 2 (100%) 1 (25%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Urinary Bladder (49) (50) (48) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant 7 (14%) 17 (34%) 14 (28%) 11 (22%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 44 42 40
Total Primary Neoplasms 91 79 92 74
Total Animals with Benign Neoplasms 33 33 32 29
Total Benign Neoplasms 50 47 53 39
Total Animals with Malignant Neoplasms 31 28 28 26
Total Malignant Neoplasms 41 32 39 35
Total Animals with Metastatic Neoplasms 13 4 3 4
Total Metastatic Neoplasm 33 5 4 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 19 20
Natural Death 4 6 6 3
Survivors
Terminal Sacrifice 29 34 25 27
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (46) (48) (48)
Adenoma 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Cecum (50) (49) (50) (50)
Intestine Small, Duodenum (49) (47) (48) (48)
Intestine Small, Jejunum (49) (48) (49) (49)
Carcinoma 1 (2%)
Intestine Small, Ileum (49) (48) (49) (50)
Carcinoma 1 (2%)
Liver (50) (50) (50) (50)
Hemangiosarcoma 3 (6%) 1 (2%)
Hepatocellular Carcinoma 10 (20%) 4 (8%) 11 (22%) 13 (26%)
Hepatocellular Carcinoma, Multiple 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Hepatocellular Adenoma 9 (18%) 17 (34%) 13 (26%) 12 (24%)
Hepatocellular Adenoma, Multiple 14 (28%) 4 (8%) 6 (12%) 4 (8%)
Mesentery (4) (5) (1) (3)
Carcinoma, Metastatic, Uncertain Primary Site 1 (25%)
Hemangiosarcoma 1 (20%)
Pancreas (49) (50) (50) (50)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (50) (49) (50) (50)
Tooth (1) (1) (1) (1)
Odontoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (50) (49) (50)
Adenoma 2 (4%) 1 (2%)
Pituitary Gland (47) (49) (49) (48)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (50) (50) (50)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (50)
Prostate (49) (50) (47) (49)
Seminal Vesicle (50) (50) (50) (50)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Testes (50) (50) (50) (50)
Interstitial Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Mast Cell Tumor Benign 1 (2%)
Lymph Node (4) (6) (3) (10)
Lymph Node, Bronchial (40) (43) (36) (38)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%)
Lymph Node, Mandibular (41) (43) (41) (38)
Lymph Node, Mesenteric (48) (49) (49) (49)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Lymph Node, Mediastinal (40) (48) (39) (45)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%)
Spleen (49) (50) (49) (50)
Page 9
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (39) (42) (37) (41)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteoma 1 (2%)
Skeletal Muscle (1) (1)
Hemangioma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 9 (18%) 9 (18%) 10 (20%)
Alveolar/Bronchiolar Adenoma, Multiple 3 (6%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 6 (12%) 2 (4%) 4 (8%) 8 (16%)
Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 5 (10%) 2 (4%) 4 (8%) 2 (4%)
Nose (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (8) (6) (4)
Adenoma 1 (100%) 4 (50%) 3 (50%) 4 (100%)
Carcinoma 3 (38%) 3 (50%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (49)
Carcinoma, Metastatic, Urinary Bladder 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 4 (8%) 7 (14%) 4 (8%) 7 (14%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 43 42 40
Total Primary Neoplasms 60 71 70 68
Total Animals with Benign Neoplasms 27 33 30 29
Total Benign Neoplasms 33 43 39 35
Total Animals with Malignant Neoplasms 24 25 24 27
Total Malignant Neoplasms 27 28 31 33
Total Animals with Metastatic Neoplasms 6 3 4 2
Total Metastatic Neoplasm 11 3 6 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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