TDMS Study 88034-04 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) OZONE NTP Experiment-Test: 88034-04 Report: PEIRPT05 Study Type: CHRONIC Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 15 10 9 9 Natural Death 6 3 6 1 Accidently Killed 2 Survivors Terminal Sacrifice 29 37 33 40 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (50) (47) (46) (50) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Intestine Large, Colon (50) (50) (47) (50) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Sarcoma Stromal, Metastatic, Uterus 1 (2%) Intestine Large, Rectum (49) (43) (45) (45) Intestine Large, Cecum (50) (50) (47) (50) Intestine Small, Duodenum (47) (48) (45) (49) Polyp Adenomatous 1 (2%) Intestine Small, Jejunum (50) (47) (46) (49) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Intestine Small, Ileum (50) (49) (45) (50) Liver (50) (50) (50) (50) Hemangiosarcoma 1 (2%) Hepatocellular Carcinoma 14 (28%) 4 (8%) 5 (10%) 3 (6%) Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) Hepatocellular Adenoma 13 (26%) 13 (26%) 12 (24%) 8 (16%) Hepatocellular Adenoma, Multiple 7 (14%) 5 (10%) 5 (10%) Hepatocholangiocarcinoma 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Mesentery (11) (4) (4) (1) Carcinoma, Metastatic, Pancreas 1 (9%) Hemangiosarcoma 1 (9%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (9%) Pancreas (49) (50) (48) (50) Carcinoma 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Salivary Glands (50) (49) (49) (50) Stomach, Forestomach (50) (50) (48) (50) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Page 2 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Squamous Cell Papilloma 1 (2%) Stomach, Glandular (50) (50) (48) (50) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Tongue (1) Squamous Cell Papilloma 1 (100%) Tooth (1) (1) Histiocytic Sarcoma 1 (100%) Odontoma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (49) (50) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Capsule, Adenoma 1 (2%) Capsule, Carcinoma 1 (2%) Adrenal Medulla (50) (50) (49) (50) Pheochromocytoma Benign 2 (4%) 2 (4%) 3 (6%) Islets, Pancreatic (49) (50) (48) (50) Adenoma 1 (2%) Carcinoma 1 (2%) Pituitary Gland (50) (50) (47) (49) Pars Distalis, Adenoma 17 (34%) 13 (26%) 14 (30%) 9 (18%) Pars Intermedia, Adenoma 3 (6%) 2 (4%) 2 (4%) Thyroid Gland (50) (50) (49) (50) Follicular Cell, Adenoma 2 (4%) 2 (4%) 4 (8%) 2 (4%) Follicular Cell, Carcinoma 3 (6%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (50) (48) (50) Cystadenoma 1 (2%) 1 (2%) 2 (4%) 1 (2%) Granulosa Cell Tumor Malignant 1 (2%) Granulosa Cell Tumor Benign 1 (2%) Page 3 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Luteoma 1 (2%) Teratoma Benign 1 (2%) Bilateral, Cystadenoma 1 (2%) Uterus (50) (50) (49) (50) Granulosa Cell Tumor Malignant, Metastatic, Ovary 1 (2%) Hemangiosarcoma 2 (4%) 2 (4%) Histiocytic Sarcoma 1 (2%) 1 (2%) Leiomyoma 1 (2%) Leiomyosarcoma 1 (2%) Polyp Stromal 1 (2%) 5 (10%) Sarcoma Stromal 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (50) Hemangiosarcoma 1 (2%) 3 (6%) 1 (2%) Histiocytic Sarcoma 1 (2%) Lymph Node (9) (6) (3) (4) Iliac, Histiocytic Sarcoma 1 (17%) Pancreatic, Histiocytic Sarcoma 1 (17%) Renal, Histiocytic Sarcoma 1 (17%) Lymph Node, Bronchial (48) (39) (40) (42) Carcinoma, Metastatic, Pancreas 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Lymph Node, Mandibular (47) (39) (43) (46) Lymph Node, Mesenteric (49) (49) (46) (47) Carcinoma, Metastatic, Pancreas 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Lymph Node, Mediastinal (41) (42) (39) (35) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Spleen (49) (50) (48) (50) Hemangiosarcoma 1 (2%) 1 (2%) 4 (8%) 2 (4%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Thymus (47) (49) (46) (47) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (48) (49) Carcinoma 1 (2%) 1 (2%) Skin (50) (50) (49) (50) Basal Cell Carcinoma 1 (2%) Squamous Cell Carcinoma 1 (2%) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) (50) Osteosarcoma 1 (2%) Skeletal Muscle (1) (1) (1) Hepatocholangiocarcinoma, Metastatic, Liver 1 (100%) Sarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (49) (50) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (49) (50) Lung (50) (50) (49) (50) Alveolar/Bronchiolar Adenoma 4 (8%) 5 (10%) 5 (10%) 7 (14%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) Alveolar/Bronchiolar Carcinoma 2 (4%) 2 (4%) 5 (10%) 8 (16%) Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (2%) 1 (2%) 1 (2%) Granulosa Cell Tumor Malignant, Metastatic, Ovary 1 (2%) Hemangiosarcoma, Metastatic, Uterus 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 2 (4%) 2 (4%) 2 (4%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Squamous Cell Carcinoma, Metastatic, Skin 1 (2%) Mediastinum, Hemangiosarcoma 1 (2%) Nose (50) (50) (48) (50) Carcinoma, Metastatic, Harderian Gland 2 (4%) ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (3) (2) (4) (3) Adenoma 1 (33%) 3 (75%) 1 (33%) Carcinoma 2 (67%) 2 (100%) 1 (25%) 2 (67%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Urinary Bladder (49) (50) (48) (50) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 1 (2%) Lymphoma Malignant 7 (14%) 17 (34%) 14 (28%) 11 (22%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 6 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 47 44 42 40 Total Primary Neoplasms 91 79 92 74 Total Animals with Benign Neoplasms 33 33 32 29 Total Benign Neoplasms 50 47 53 39 Total Animals with Malignant Neoplasms 31 28 28 26 Total Malignant Neoplasms 41 32 39 35 Total Animals with Metastatic Neoplasms 13 4 3 4 Total Metastatic Neoplasm 33 5 4 4 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 16 10 19 20 Natural Death 4 6 6 3 Survivors Terminal Sacrifice 29 34 25 27 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (46) (48) (48) Adenoma 1 (2%) Carcinoma, Metastatic, Uncertain Primary Site 1 (2%) Intestine Large, Colon (50) (50) (50) (50) Intestine Large, Cecum (50) (49) (50) (50) Intestine Small, Duodenum (49) (47) (48) (48) Intestine Small, Jejunum (49) (48) (49) (49) Carcinoma 1 (2%) Intestine Small, Ileum (49) (48) (49) (50) Carcinoma 1 (2%) Liver (50) (50) (50) (50) Hemangiosarcoma 3 (6%) 1 (2%) Hepatocellular Carcinoma 10 (20%) 4 (8%) 11 (22%) 13 (26%) Hepatocellular Carcinoma, Multiple 2 (4%) 2 (4%) 2 (4%) 2 (4%) Hepatocellular Adenoma 9 (18%) 17 (34%) 13 (26%) 12 (24%) Hepatocellular Adenoma, Multiple 14 (28%) 4 (8%) 6 (12%) 4 (8%) Mesentery (4) (5) (1) (3) Carcinoma, Metastatic, Uncertain Primary Site 1 (25%) Hemangiosarcoma 1 (20%) Pancreas (49) (50) (50) (50) Salivary Glands (50) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 2 (4%) Stomach, Glandular (50) (49) (50) (50) Tooth (1) (1) (1) (1) Odontoma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 1 (2%) Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (49) (50) (49) (50) Adenoma 2 (4%) 1 (2%) Pituitary Gland (47) (49) (49) (48) Pars Intermedia, Adenoma 1 (2%) Thyroid Gland (49) (50) (50) (50) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Preputial Gland (50) (50) (50) (50) Prostate (49) (50) (47) (49) Seminal Vesicle (50) (50) (50) (50) Carcinoma, Metastatic, Uncertain Primary Site 1 (2%) Testes (50) (50) (50) (50) Interstitial Cell, Adenoma 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Mast Cell Tumor Benign 1 (2%) Lymph Node (4) (6) (3) (10) Lymph Node, Bronchial (40) (43) (36) (38) Hepatocellular Carcinoma, Metastatic, Liver 1 (3%) Lymph Node, Mandibular (41) (43) (41) (38) Lymph Node, Mesenteric (48) (49) (49) (49) Carcinoma, Metastatic, Uncertain Primary Site 1 (2%) Lymph Node, Mediastinal (40) (48) (39) (45) Hepatocellular Carcinoma, Metastatic, Liver 1 (3%) Spleen (49) (50) (49) (50) Page 9 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Carcinoma, Metastatic, Uncertain Primary Site 1 (2%) Hemangiosarcoma 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) Thymus (39) (42) (37) (41) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) (50) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteoma 1 (2%) Skeletal Muscle (1) (1) Hemangioma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) (50) Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 6 (12%) 9 (18%) 9 (18%) 10 (20%) Alveolar/Bronchiolar Adenoma, Multiple 3 (6%) 1 (2%) Alveolar/Bronchiolar Carcinoma 6 (12%) 2 (4%) 4 (8%) 8 (16%) Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) 2 (4%) 4 (8%) 2 (4%) Carcinoma, Metastatic, Harderian Gland 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 5 (10%) 2 (4%) 4 (8%) 2 (4%) Nose (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (1) (8) (6) (4) Adenoma 1 (100%) 4 (50%) 3 (50%) 4 (100%) Carcinoma 3 (38%) 3 (50%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Renal Tubule, Adenoma 1 (2%) 1 (2%) Renal Tubule, Carcinoma 1 (2%) Urinary Bladder (50) (50) (50) (49) Carcinoma, Metastatic, Urinary Bladder 1 (2%) Transitional Epithelium, Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) Lymphoma Malignant 4 (8%) 7 (14%) 4 (8%) 7 (14%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 11 NTP Experiment-Test: 88034-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:38:33 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 39 43 42 40 Total Primary Neoplasms 60 71 70 68 Total Animals with Benign Neoplasms 27 33 30 29 Total Benign Neoplasms 33 43 39 35 Total Animals with Malignant Neoplasms 24 25 24 27 Total Malignant Neoplasms 27 28 31 33 Total Animals with Metastatic Neoplasms 6 3 4 2 Total Metastatic Neoplasm 11 3 6 2 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 12 ------------------------------------------------------------ ---------- END 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