TDMS Study 88034-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 04 TIME: 20:53:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88034
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 04 TIME: 20:53:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88034
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 04 TIME: 20:53:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88034
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 6 OZONE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Carcinoma or Adenoma
Liver Hepatocellular Carcinoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Polyp Stromal
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
Cell Type
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 2/50 (4%) 3/49 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.7% | 6.9% 5.4% 8.5% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 0/25 (0%) 1/27 (4%) | 2/29 (7%) 2/37 (5%) 2/33 (6%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 733 (T) | 735 (T) 735 (T) 693 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.167 (e) (e) P=0.479 | P=0.152N P=0.605N P=0.559 P=0.171N |
|INCIDENTAL TUMOR | P=0.167 (e) (e) P=0.479 | P=0.179N P=0.605N P=0.538 P=0.171N |
|LOGISTIC REGRESSION | P=0.167 (e) (e) P=0.479 | P=0.175N P=0.605N P=0.541 P=0.171N |
|COCHRAN-ARMITAGE | P=0.188 | P=0.204N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.691N P=0.490 P=0.247N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 2/50 (4%) 3/49 (6%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% 3.7% | 6.9% 5.4% 8.5% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 0/25 (0%) 1/27 (4%) | 2/29 (7%) 2/37 (5%) 2/33 (6%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 612 --- 733 (T) | 735 (T) 735 (T) 693 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.419 P=0.510 (e) P=0.479 | P=0.152N P=0.605N P=0.559 P=0.171N |
|INCIDENTAL TUMOR | P=0.476 P=0.443 (e) P=0.479 | P=0.179N P=0.605N P=0.538 P=0.171N |
|LOGISTIC REGRESSION | P=0.449 P=0.464 (e) P=0.479 | P=0.175N P=0.605N P=0.541 P=0.171N |
|COCHRAN-ARMITAGE | P=0.456 | P=0.204N |
|FISHER EXACT | P=0.500 (e) P=0.500 | P=0.691N P=0.490 P=0.247N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 3/49 (6%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.3% 0.0% 8.4% 2.5% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 0/37 (0%) 2/33 (6%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 728 --- 677 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.463 P=0.458N P=0.354 P=0.691N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.327 P=0.590N P=0.311 P=0.677 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.414 P=0.473N P=0.322 P=0.723N |
|COCHRAN-ARMITAGE | (e) | P=0.396 |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.301 P=0.753N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 3/50 (6%) 4/50 (8%) | 1/50 (2%) 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 2.0% 11.8% 9.7% 13.1% | 3.4% 0.0% 8.0% 2.5% |
|TERMINAL (d) | 0/30 (0%) 4/34 (12%) 1/25 (4%) 3/27 (11%) | 1/29 (3%) 0/37 (0%) 2/33 (6%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 362 733 (T) 621 506 | 735 (T) --- 527 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.183 P=0.213 P=0.268 P=0.162 | P=0.456 P=0.451N P=0.341 P=0.688N |
|INCIDENTAL TUMOR | P=0.270 P=0.079 P=0.250 P=0.195 | P=0.478 P=0.451N P=0.261 P=0.688N |
|LOGISTIC REGRESSION | P=0.246 P=0.164 P=0.335 P=0.199 | P=0.395 P=0.451N P=0.303 P=0.688N |
|COCHRAN-ARMITAGE | P=0.253 | P=0.397 |
|FISHER EXACT | P=0.181 P=0.309 P=0.181 | P=0.500N P=0.309 P=0.753N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 3/50 (6%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 8.8% 10.5% 0.0% | 4.8% 5.4% 2.3% 4.5% |
|TERMINAL (d) | 0/30 (0%) 3/34 (9%) 1/25 (4%) 0/27 (0%) | 0/29 (0%) 2/37 (5%) 0/33 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 659 --- | 538 735 (T) 659 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.444N P=0.143 P=0.095 (e) | P=0.513N P=0.630N P=0.477N P=0.651N |
|INCIDENTAL TUMOR | P=0.449N P=0.143 P=0.106 (e) | P=0.578N P=0.621 P=0.602N P=0.625 |
|LOGISTIC REGRESSION | P=0.425N P=0.143 P=0.107 (e) | P=0.564N P=0.668 P=0.478N P=0.665 |
|COCHRAN-ARMITAGE | P=0.367N | P=0.561N |
|FISHER EXACT | P=0.121 P=0.121 (e) | P=0.691N P=0.500N P=0.691N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 7/50 (14%) 6/50 (12%) 4/50 (8%) | 3/50 (6%) 2/50 (4%) 4/50 (8%) 3/50 (6%) |
|ADJUSTED (b) | 2.0% 20.6% 19.4% 13.1% | 8.1% 5.4% 10.2% 6.9% |
|TERMINAL (d) | 0/30 (0%) 7/34 (21%) 2/25 (8%) 3/27 (11%) | 1/29 (3%) 2/37 (5%) 2/33 (6%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 362 733 (T) 621 506 | 538 735 (T) 527 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306 P=0.046 * P=0.044 * P=0.162 | P=0.535 P=0.417N P=0.545 P=0.575N |
|INCIDENTAL TUMOR | P=0.388 P=0.013 * P=0.043 * P=0.195 | P=0.500 P=0.553N P=0.395 P=0.653 |
|LOGISTIC REGRESSION | P=0.384 P=0.034 * P=0.064 P=0.199 | P=0.454 P=0.520N P=0.504 P=0.632 |
|COCHRAN-ARMITAGE | P=0.425 | P=0.460 |
|FISHER EXACT | P=0.030 * P=0.056 P=0.181 | P=0.500N P=0.500 P=0.661N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/50 (4%) 0/49 (0%) 1/50 (2%) | 0/49 (0%) 0/50 (0%) 1/48 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.4% 0.0% 3.6% | 0.0% 0.0% 3.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/34 (3%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 0/37 (0%) 1/33 (3%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 667 --- 709 | --- --- 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.576 P=0.266 (e) P=0.480 | P=0.682 (e) P=0.526 (e) |
|INCIDENTAL TUMOR | P=0.568 P=0.233 (e) P=0.419 | P=0.682 (e) P=0.526 (e) |
|LOGISTIC REGRESSION | P=0.600 P=0.247 (e) P=0.479 | P=0.682 (e) P=0.526 (e) |
|COCHRAN-ARMITAGE | P=0.634 | P=0.655 |
|FISHER EXACT | P=0.253 (e) P=0.505 | (e) P=0.495 (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/50 (4%) 0/49 (0%) 1/50 (2%) | 0/49 (0%) 0/50 (0%) 1/48 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 5.4% 0.0% 3.6% | 0.0% 0.0% 3.0% 2.5% |
|TERMINAL (d) | 0/30 (0%) 1/34 (3%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 0/37 (0%) 1/33 (3%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- 667 --- 709 | --- --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.576 P=0.266 (e) P=0.480 | P=0.253 (e) P=0.526 P=0.564 |
|INCIDENTAL TUMOR | P=0.568 P=0.233 (e) P=0.419 | P=0.253 (e) P=0.526 P=0.564 |
|LOGISTIC REGRESSION | P=0.600 P=0.247 (e) P=0.479 | P=0.253 (e) P=0.526 P=0.564 |
|COCHRAN-ARMITAGE | P=0.634 | P=0.214 |
|FISHER EXACT | P=0.253 (e) P=0.505 | (e) P=0.495 P=0.505 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.5% 2.9% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/30 (3%) 1/34 (3%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 0/37 (0%) 0/33 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 596 733 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.129N P=0.474N P=0.283N P=0.274N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.107N P=0.504N P=0.246N P=0.226N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.111N P=0.495N P=0.239N P=0.239N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.104N | (e) |
|FISHER EXACT | P=0.500N P=0.247N P=0.247N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.2% 3.3% 0.0% | 0.0% 0.0% 3.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/34 (3%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 0/37 (0%) 1/33 (3%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 540 659 --- | --- --- 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303N P=0.134 P=0.469 (e) | P=0.682 (e) P=0.526 (e) |
|INCIDENTAL TUMOR | P=0.227N P=0.126 P=0.500 (e) | P=0.682 (e) P=0.526 (e) |
|LOGISTIC REGRESSION | P=0.231N P=0.091 P=0.500 (e) | P=0.682 (e) P=0.526 (e) |
|COCHRAN-ARMITAGE | P=0.254N | P=0.655 |
|FISHER EXACT | P=0.121 P=0.500 (e) | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 21/50 (42%) 19/50 (38%) 16/50 (32%) | 20/50 (40%) 18/50 (36%) 17/50 (34%) 8/50 (16%) |
|ADJUSTED (b) | 65.0% 53.6% 59.5% 43.3% | 59.9% 48.6% 43.2% 18.6% |
|TERMINAL (d) | 18/30 (60%) 16/34 (47%) 13/25 (52%) 8/27 (30%) | 16/29 (55%) 18/37 (49%) 12/33 (36%) 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 446 545 484 462 | 538 735 (T) 488 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293N P=0.250N P=0.541N P=0.229N | P<0.001N** P=0.118N P=0.200N P<0.001N** |
|INCIDENTAL TUMOR | P=0.143N P=0.305N P=0.369N P=0.122N | P=0.001N** P=0.183N P=0.321N P=0.002N** |
|LOGISTIC REGRESSION | P=0.159N P=0.333N P=0.401N P=0.148N | P=0.004N** P=0.231N P=0.297N P=0.005N** |
|COCHRAN-ARMITAGE | P=0.084N | P=0.005N** |
|FISHER EXACT | P=0.420N P=0.272N P=0.109N | P=0.418N P=0.339N P=0.007N** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 6/50 (12%) 13/50 (26%) 15/50 (30%) | 15/50 (30%) 5/50 (10%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | 29.2% 13.1% 31.8% 38.5% | 39.5% 11.4% 12.5% 7.3% |
|TERMINAL (d) | 4/30 (13%) 1/34 (3%) 2/25 (8%) 5/27 (19%) | 7/29 (24%) 1/37 (3%) 2/33 (6%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 362 440 460 350 | 566 567 644 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.047 * P=0.091N P=0.391 P=0.258 | P=0.003N** P=0.007N** P=0.010N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.145 P=0.128N P=0.422N P=0.352 | P=0.018N* P=0.020N* P=0.009N** P=0.013N* |
|LOGISTIC REGRESSION | P=0.188 P=0.100N P=0.469N P=0.392 | P=0.014N* P=0.018N* P=0.011N* P=0.002N** |
|COCHRAN-ARMITAGE | P=0.075 | P=0.005N** |
|FISHER EXACT | P=0.096N P=0.500 P=0.326 | P=0.011N* P=0.011N* P=0.002N** |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 27/50 (54%) 29/50 (58%) 29/50 (58%) | 27/50 (54%) 22/50 (44%) 20/50 (40%) 11/50 (22%) |
|ADJUSTED (b) | 70.7% 60.7% 70.8% 66.9% | 68.6% 53.2% 48.5% 25.2% |
|TERMINAL (d) | 18/30 (60%) 17/34 (50%) 14/25 (56%) 13/27 (48%) | 17/29 (59%) 18/37 (49%) 13/33 (39%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 362 440 460 350 | 538 567 488 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206 P=0.218N P=0.362 P=0.434 | P<0.001N** P=0.049N* P=0.064N P<0.001N** |
|INCIDENTAL TUMOR | P=0.522 P=0.313N P=0.389N P=0.521N | P=0.001N** P=0.141N P=0.112N P=0.002N** |
|LOGISTIC REGRESSION | P=0.517 P=0.356N P=0.506N P=0.512N | P<0.001N** P=0.141N P=0.103N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.512 | P<0.001N** |
|FISHER EXACT | P=0.343N P=0.500N P=0.500N | P=0.212N P=0.115N P<0.001N** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 27/50 (54%) 29/50 (58%) 29/50 (58%) | 27/50 (54%) 22/50 (44%) 20/50 (40%) 11/50 (22%) |
|ADJUSTED (b) | 70.7% 60.7% 70.8% 66.9% | 68.6% 53.2% 48.5% 25.2% |
|TERMINAL (d) | 18/30 (60%) 17/34 (50%) 14/25 (56%) 13/27 (48%) | 17/29 (59%) 18/37 (49%) 13/33 (39%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 362 440 460 350 | 538 567 488 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206 P=0.218N P=0.362 P=0.434 | P<0.001N** P=0.049N* P=0.064N P<0.001N** |
|INCIDENTAL TUMOR | P=0.522 P=0.313N P=0.389N P=0.521N | P=0.001N** P=0.141N P=0.112N P=0.002N** |
|LOGISTIC REGRESSION | P=0.517 P=0.356N P=0.506N P=0.512N | P<0.001N** P=0.141N P=0.103N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.512 | P<0.001N** |
|FISHER EXACT | P=0.343N P=0.500N P=0.500N | P=0.212N P=0.115N P<0.001N** |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) 12/50 (24%) 11/50 (22%) | 4/50 (8%) 5/50 (10%) 5/49 (10%) 8/50 (16%) |
|ADJUSTED (b) | 18.8% 25.1% 40.9% 34.7% | 12.5% 12.9% 13.4% 20.0% |
|TERMINAL (d) | 5/30 (17%) 8/34 (24%) 9/25 (36%) 8/27 (30%) | 3/29 (10%) 4/37 (11%) 2/33 (6%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 611 440 464 484 | 636 681 667 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.053 P=0.372 P=0.045 * P=0.100 | P=0.233 P=0.631 P=0.573 P=0.349 |
|INCIDENTAL TUMOR | P=0.086 P=0.365 P=0.063 P=0.145 | P=0.122 P=0.571 P=0.490 P=0.298 |
|LOGISTIC REGRESSION | P=0.079 P=0.318 P=0.061 P=0.110 | P=0.153 P=0.549 P=0.515 P=0.239 |
|COCHRAN-ARMITAGE | P=0.130 | P=0.130 |
|FISHER EXACT | P=0.288 P=0.096 P=0.143 | P=0.500 P=0.487 P=0.178 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 4/50 (8%) 8/50 (16%) 10/50 (20%) | 2/50 (4%) 2/50 (4%) 5/49 (10%) 8/50 (16%) |
|ADJUSTED (b) | 25.5% 10.3% 30.7% 35.4% | 6.9% 5.2% 14.1% 19.2% |
|TERMINAL (d) | 7/30 (23%) 1/34 (3%) 7/25 (28%) 9/27 (33%) | 2/29 (7%) 1/37 (3%) 3/33 (9%) 7/40 (18%) |
|FIRST INCIDENCE (DAYS) | 653 612 701 630 | 735 (T) 703 709 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063 P=0.135N P=0.451 P=0.294 | P=0.025 * P=0.608N P=0.275 P=0.114 |
|INCIDENTAL TUMOR | P=0.068 P=0.170N P=0.469 P=0.300 | P=0.012 * P=0.670N P=0.244 P=0.114 |
|LOGISTIC REGRESSION | P=0.062 P=0.154N P=0.449 P=0.270 | P=0.011 * P=0.649N P=0.259 P=0.053 |
|COCHRAN-ARMITAGE | P=0.145 | P=0.010 ** |
|FISHER EXACT | P=0.178N P=0.607N P=0.398 | P=0.691N P=0.210 P=0.046 * |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 13/50 (26%) 18/50 (36%) 19/50 (38%) | 6/50 (12%) 7/50 (14%) 9/49 (18%) 16/50 (32%) |
|ADJUSTED (b) | 43.1% 33.4% 60.9% 60.0% | 19.2% 17.7% 24.0% 38.8% |
|TERMINAL (d) | 12/30 (40%) 9/34 (26%) 14/25 (56%) 15/27 (56%) | 5/29 (17%) 5/37 (14%) 5/33 (15%) 15/40 (38%) |
|FIRST INCIDENCE (DAYS) | 611 440 464 484 | 636 681 667 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.020 * P=0.368N P=0.099 P=0.103 | P=0.020 * P=0.568N P=0.386 P=0.074 |
|INCIDENTAL TUMOR | P=0.034 * P=0.422N P=0.133 P=0.142 | P=0.005 ** P=0.578 P=0.308 P=0.059 |
|LOGISTIC REGRESSION | P=0.030 * P=0.445N P=0.124 P=0.103 | P=0.005 ** P=0.571 P=0.326 P=0.022 * |
|COCHRAN-ARMITAGE | P=0.094 | P=0.004 ** |
|FISHER EXACT | P=0.500N P=0.260 P=0.198 | P=0.500 P=0.274 P=0.014 * |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 2/50 (4%) 2/48 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 3.4% 5.1% 5.3% 2.4% |
|TERMINAL (d) | | 1/29 (3%) 1/37 (3%) 1/33 (3%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | | 735 (T) 687 667 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.465N P=0.572 P=0.541 P=0.704N |
|INCIDENTAL TUMOR | | P=0.573 P=0.505 P=0.507 P=0.677 |
|LOGISTIC REGRESSION | | P=0.524N P=0.529 P=0.501 P=0.755N |
|COCHRAN-ARMITAGE | | P=0.528N |
|FISHER EXACT | | P=0.500 P=0.485 P=0.753N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 0/48 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 5.4% 0.0% 0.0% |
|TERMINAL (d) | | 0/29 (0%) 2/37 (5%) 0/33 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.245N P=0.293 (e) (e) |
|INCIDENTAL TUMOR | | P=0.245N P=0.293 (e) (e) |
|LOGISTIC REGRESSION | | P=0.245N P=0.293 (e) (e) |
|COCHRAN-ARMITAGE | | P=0.282N |
|FISHER EXACT | | P=0.247 (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/49 (0%) 0/49 (0%) 0/48 (0%) | 17/50 (34%) 13/50 (26%) 14/47 (30%) 9/49 (18%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 48.7% 32.1% 40.1% 22.1% |
|TERMINAL (d) | 0/29 (0%) 0/34 (0%) 0/25 (0%) 0/27 (0%) | 12/29 (41%) 10/37 (27%) 11/31 (35%) 8/39 (21%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 511 653 644 488 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.025N* P=0.098N P=0.254N P=0.011N* |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.062N P=0.201N P=0.363N P=0.034N* |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.067N P=0.193N P=0.345N P=0.050N* |
|COCHRAN-ARMITAGE | (e) | P=0.080N |
|FISHER EXACT | (e) (e) (e) | P=0.257N P=0.411N P=0.061N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 0/49 (0%) 0/49 (0%) 0/48 (0%) | 0/50 (0%) 3/50 (6%) 2/47 (4%) 2/49 (4%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% 0.0% | 0.0% 8.1% 5.6% 5.1% |
|TERMINAL (d) | 0/29 (0%) 0/34 (0%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 3/37 (8%) 1/31 (3%) 2/39 (5%) |
|FIRST INCIDENCE (DAYS) | 611 --- --- --- | --- 735 (T) 677 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.369N P=0.495N P=0.532N P=0.527N | P=0.465 P=0.167 P=0.262 P=0.306 |
|INCIDENTAL TUMOR | P=0.298N P=0.531N P=0.450N P=0.450N | P=0.412 P=0.167 P=0.236 P=0.306 |
|LOGISTIC REGRESSION | P=0.319N P=0.525N P=0.476N P=0.478N | P=0.412 P=0.167 P=0.228 P=0.306 |
|COCHRAN-ARMITAGE | P=0.344N | P=0.382 |
|FISHER EXACT | P=0.490N P=0.490N P=0.495N | P=0.121 P=0.232 P=0.242 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 1/49 (2%) 0/50 (0%) | 1/49 (2%) 1/50 (2%) 4/48 (8%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.9% 3.3% 0.0% | 3.3% 2.7% 11.3% 5.0% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 1/37 (3%) 3/33 (9%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | --- 699 659 --- | 728 735 (T) 677 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.591N P=0.518 P=0.469 (e) | P=0.364 P=0.709N P=0.224 P=0.607 |
|INCIDENTAL TUMOR | P=0.614N P=0.464 P=0.500 (e) | P=0.265 P=0.750 P=0.191 P=0.446 |
|LOGISTIC REGRESSION | P=0.553N P=0.509 P=0.501 (e) | P=0.313 P=0.725N P=0.198 P=0.575 |
|COCHRAN-ARMITAGE | P=0.541N | P=0.284 |
|FISHER EXACT | P=0.505 P=0.500 (e) | P=0.747N P=0.175 P=0.508 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 8.3% 0.0% 0.0% | 0.0% 2.7% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 2/34 (6%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 1/37 (3%) 0/33 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 667 --- --- | --- 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.224N P=0.145 (e) (e) | P=0.432N P=0.549 (e) (e) |
|INCIDENTAL TUMOR | P=0.222N P=0.126 (e) (e) | P=0.432N P=0.549 (e) (e) |
|LOGISTIC REGRESSION | P=0.210N P=0.129 (e) (e) | P=0.432N P=0.549 (e) (e) |
|COCHRAN-ARMITAGE | P=0.183N | P=0.464N |
|FISHER EXACT | P=0.121 (e) (e) | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.4% 0.0% 0.0% | 0.0% 2.7% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/34 (3%) 0/25 (0%) 0/27 (0%) | 0/29 (0%) 1/37 (3%) 0/33 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- 667 --- --- | --- 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.323N P=0.266 (e) (e) | P=0.432N P=0.549 (e) (e) |
|INCIDENTAL TUMOR | P=0.321N P=0.233 (e) (e) | P=0.432N P=0.549 (e) (e) |
|LOGISTIC REGRESSION | P=0.300N P=0.245 (e) (e) | P=0.432N P=0.549 (e) (e) |
|COCHRAN-ARMITAGE | P=0.280N | P=0.464N |
|FISHER EXACT | P=0.247 (e) (e) | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | |
|ADJUSTED (b) | 0.0% 5.9% 0.0% 0.0% | |
|TERMINAL (d) | 0/30 (0%) 2/34 (6%) 0/25 (0%) 0/27 (0%) | |
|FIRST INCIDENCE (DAYS) | --- 733 (T) --- --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.316N P=0.266 (e) (e) | |
|INCIDENTAL TUMOR | P=0.316N P=0.266 (e) (e) | |
|LOGISTIC REGRESSION | P=0.316N P=0.266 (e) (e) | |
|COCHRAN-ARMITAGE | P=0.280N | |
|FISHER EXACT | P=0.247 (e) (e) | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 4/49 (8%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 4.0% 0.0% | 6.9% 5.4% 12.1% 5.0% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 1/25 (4%) 0/27 (0%) | 2/29 (7%) 2/37 (5%) 4/33 (12%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) --- | 735 (T) 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.627 (e) P=0.464 (e) | P=0.535N P=0.605N P=0.397 P=0.574N |
|INCIDENTAL TUMOR | P=0.627 (e) P=0.464 (e) | P=0.535N P=0.605N P=0.397 P=0.574N |
|LOGISTIC REGRESSION | P=0.627 (e) P=0.464 (e) | P=0.535N P=0.605N P=0.397 P=0.574N |
|COCHRAN-ARMITAGE | P=0.657 | P=0.518 |
|FISHER EXACT | (e) P=0.505 (e) | P=0.691N P=0.329 P=0.691N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 0/25 (0%) 0/27 (0%) | 1/29 (3%) 0/37 (0%) 0/33 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 531 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.067N P=0.098N P=0.111N P=0.092N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.086N P=0.188N P=0.172N P=0.165N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.075N P=0.136N P=0.123N P=0.129N |
|COCHRAN-ARMITAGE | (e) | P=0.076N |
|FISHER EXACT | (e) (e) (e) | P=0.121N P=0.125N P=0.121N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 5/50 (10%) 2/50 (4%) 4/49 (8%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 4.0% 0.0% | 15.1% 5.4% 12.1% 5.0% |
|TERMINAL (d) | 0/30 (0%) 0/34 (0%) 1/25 (4%) 0/27 (0%) | 3/29 (10%) 2/37 (5%) 4/33 (12%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) --- | 531 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.627 (e) P=0.464 (e) | P=0.200N P=0.146N P=0.431N P=0.127N |
|INCIDENTAL TUMOR | P=0.627 (e) P=0.464 (e) | P=0.221N P=0.220N P=0.503N P=0.187N |
|LOGISTIC REGRESSION | P=0.627 (e) P=0.464 (e) | P=0.266N P=0.206N P=0.488N P=0.207N |
|COCHRAN-ARMITAGE | P=0.657 | P=0.286N |
|FISHER EXACT | (e) P=0.505 (e) | P=0.218N P=0.513N P=0.218N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 5.4% 5.0% |
|TERMINAL (d) | | 0/29 (0%) 0/37 (0%) 1/33 (3%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | | --- --- 677 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.098 (e) P=0.269 P=0.312 |
|INCIDENTAL TUMOR | | P=0.065 (e) P=0.254 P=0.312 |
|LOGISTIC REGRESSION | | P=0.076 (e) P=0.241 P=0.312 |
|COCHRAN-ARMITAGE | | P=0.072 |
|FISHER EXACT | | (e) P=0.247 P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 0/50 (0%) 0/50 (0%) 5/50 (10%) |
|ADJUSTED (b) | | 3.4% 0.0% 0.0% 11.4% |
|TERMINAL (d) | | 1/29 (3%) 0/37 (0%) 0/33 (0%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | | 735 (T) --- --- 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.012 * P=0.451N P=0.474N P=0.164 |
|INCIDENTAL TUMOR | | P=0.010 ** P=0.451N P=0.474N P=0.118 |
|LOGISTIC REGRESSION | | P=0.006 ** P=0.451N P=0.474N P=0.092 |
|COCHRAN-ARMITAGE | | P=0.007 ** |
|FISHER EXACT | | P=0.500N P=0.500N P=0.102 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 5.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | | 0/29 (0%) 0/37 (0%) 0/33 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | | 601 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.151N P=0.216N P=0.226N P=0.223N |
|INCIDENTAL TUMOR | | P=0.242N P=0.316N P=0.295N P=0.500N |
|LOGISTIC REGRESSION | | P=0.149N P=0.269N P=0.226N P=0.254N |
|COCHRAN-ARMITAGE | | P=0.154N |
|FISHER EXACT | | P=0.247N P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 0/50 (0%) 0/50 (0%) 5/50 (10%) |
|ADJUSTED (b) | | 8.3% 0.0% 0.0% 11.4% |
|TERMINAL (d) | | 1/29 (3%) 0/37 (0%) 0/33 (0%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | | 601 --- --- 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.110 P=0.098N P=0.109N P=0.462 |
|INCIDENTAL TUMOR | | P=0.056 P=0.148N P=0.145N P=0.245 |
|LOGISTIC REGRESSION | | P=0.078 P=0.133N P=0.120N P=0.324 |
|COCHRAN-ARMITAGE | | P=0.081 |
|FISHER EXACT | | P=0.121N P=0.121N P=0.357 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 5/50 (10%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 12.6% 3.3% 0.0% | 6.7% 2.7% 17.2% 7.5% |
|TERMINAL (d) | 0/30 (0%) 2/34 (6%) 0/25 (0%) 0/27 (0%) | 1/29 (3%) 1/37 (3%) 5/33 (15%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | --- 540 659 --- | 728 735 (T) 677 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.168N P=0.044 * P=0.469 (e) | P=0.318 P=0.420N P=0.182 P=0.641 |
|INCIDENTAL TUMOR | P=0.123N P=0.036 * P=0.500 (e) | P=0.243 P=0.495N P=0.168 P=0.513 |
|LOGISTIC REGRESSION | P=0.122N P=0.029 * P=0.500 (e) | P=0.264 P=0.438N P=0.165 P=0.605 |
|COCHRAN-ARMITAGE | P=0.125N | P=0.220 |
|FISHER EXACT | P=0.028 * P=0.500 (e) | P=0.500N P=0.134 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 5/50 (10%) 2/50 (4%) 1/50 (2%) | 2/50 (4%) 1/50 (2%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 12.6% 7.2% 3.7% | 6.7% 2.7% 17.2% 7.5% |
|TERMINAL (d) | 0/30 (0%) 2/34 (6%) 1/25 (4%) 1/27 (4%) | 1/29 (3%) 1/37 (3%) 5/33 (15%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | --- 540 659 733 (T) | 728 735 (T) 677 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.442N P=0.044 * P=0.204 P=0.479 | P=0.318 P=0.420N P=0.182 P=0.641 |
|INCIDENTAL TUMOR | P=0.381N P=0.036 * P=0.220 P=0.479 | P=0.243 P=0.495N P=0.168 P=0.513 |
|LOGISTIC REGRESSION | P=0.378N P=0.029 * P=0.218 P=0.479 | P=0.264 P=0.438N P=0.165 P=0.605 |
|COCHRAN-ARMITAGE | P=0.359N | P=0.220 |
|FISHER EXACT | P=0.028 * P=0.247 P=0.500 | P=0.500N P=0.134 P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 8/50 (16%) 4/50 (8%) 7/50 (14%) | 7/50 (14%) 18/50 (36%) 14/50 (28%) 12/50 (24%) |
|ADJUSTED (b) | 10.8% 21.0% 12.5% 19.8% | 20.3% 40.2% 38.6% 27.3% |
|TERMINAL (d) | 1/30 (3%) 5/34 (15%) 2/25 (8%) 3/27 (11%) | 4/29 (14%) 11/37 (30%) 11/33 (33%) 9/40 (23%) |
|FIRST INCIDENCE (DAYS) | 596 600 544 484 | 636 471 704 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.289 P=0.229 P=0.554 P=0.213 | P=0.415N P=0.049 * P=0.130 P=0.330 |
|INCIDENTAL TUMOR | P=0.455 P=0.146 P=0.604N P=0.303 | P=0.449 P=0.009 ** P=0.097 P=0.182 |
|LOGISTIC REGRESSION | P=0.411 P=0.183 P=0.640N P=0.275 | P=0.460 P=0.009 ** P=0.095 P=0.142 |
|COCHRAN-ARMITAGE | P=0.411 | P=0.458 |
|FISHER EXACT | P=0.178 P=0.643N P=0.262 | P=0.010 ** P=0.070 P=0.154 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 7/50 (14%) 4/50 (8%) 7/50 (14%) | 7/50 (14%) 17/50 (34%) 14/50 (28%) 11/50 (22%) |
|ADJUSTED (b) | 10.8% 18.2% 12.5% 19.8% | 20.3% 38.9% 38.6% 24.9% |
|TERMINAL (d) | 1/30 (3%) 4/34 (12%) 2/25 (8%) 3/27 (11%) | 4/29 (14%) 11/37 (30%) 11/33 (33%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 596 600 544 484 | 636 471 704 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.238 P=0.315 P=0.554 P=0.213 | P=0.371N P=0.070 P=0.130 P=0.407 |
|INCIDENTAL TUMOR | P=0.396 P=0.214 P=0.604N P=0.303 | P=0.515 P=0.017 * P=0.097 P=0.240 |
|LOGISTIC REGRESSION | P=0.372 P=0.262 P=0.640N P=0.275 | P=0.513 P=0.017 * P=0.095 P=0.200 |
|COCHRAN-ARMITAGE | P=0.347 | P=0.509 |
|FISHER EXACT | P=0.262 P=0.643N P=0.262 | P=0.017 * P=0.070 P=0.218 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 33/50 (66%) 30/50 (60%) 29/50 (58%) | 33/50 (66%) 33/50 (66%) 32/50 (64%) 29/50 (58%) |
|ADJUSTED (b) | 72.1% 80.3% 84.9% 75.2% | 86.4% 78.5% 72.2% 62.7% |
|TERMINAL (d) | 20/30 (67%) 26/34 (76%) 20/25 (80%) 18/27 (67%) | 24/29 (83%) 28/37 (76%) 21/33 (64%) 23/40 (58%) |
|FIRST INCIDENCE (DAYS) | 362 440 464 462 | 511 653 488 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.174 P=0.369 P=0.105 P=0.239 | P=0.031N* P=0.109N P=0.255N P=0.021N* |
|INCIDENTAL TUMOR | P=0.388 P=0.199 P=0.198 P=0.376 | P=0.115N P=0.321N P=0.505N P=0.107N |
|LOGISTIC REGRESSION | P=0.347 P=0.206 P=0.224 P=0.321 | P=0.176N P=0.372N P=0.453N P=0.230N |
|COCHRAN-ARMITAGE | P=0.502N | P=0.201N |
|FISHER EXACT | P=0.154 P=0.343 P=0.420 | P=0.583N P=0.500N P=0.268N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 25/50 (50%) 25/50 (50%) 27/50 (54%) | 31/50 (62%) 28/50 (56%) 28/50 (56%) 26/50 (52%) |
|ADJUSTED (b) | 58.5% 53.7% 60.3% 66.4% | 65.5% 59.3% 63.5% 57.4% |
|TERMINAL (d) | 13/30 (43%) 13/34 (38%) 10/25 (40%) 14/27 (52%) | 13/29 (45%) 18/37 (49%) 17/33 (52%) 21/40 (53%) |
|FIRST INCIDENCE (DAYS) | 362 440 145 350 | 439 471 644 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.155 P=0.422N P=0.350 P=0.280 | P=0.081N P=0.140N P=0.216N P=0.052N |
|INCIDENTAL TUMOR | P=0.417 P=0.523 P=0.468N P=0.403 | P=0.382N P=0.552N P=0.417N P=0.381N |
|LOGISTIC REGRESSION | P=0.439 P=0.528 P=0.523N P=0.417 | P=0.221N P=0.513N P=0.341N P=0.259N |
|COCHRAN-ARMITAGE | P=0.367 | P=0.215N |
|FISHER EXACT | P=0.579N P=0.579N P=0.421 | P=0.342N P=0.342N P=0.210N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 04 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 40/50 (80%) 43/50 (86%) 43/50 (86%) 40/50 (80%) | 47/50 (94%) 44/50 (88%) 42/50 (84%) 40/50 (80%) |
|ADJUSTED (b) | 88.7% 87.8% 93.3% 90.8% | 94.0% 89.8% 87.4% 86.8% |
|TERMINAL (d) | 25/30 (83%) 28/34 (82%) 22/25 (88%) 23/27 (85%) | 26/29 (90%) 32/37 (86%) 27/33 (82%) 34/40 (85%) |
|FIRST INCIDENCE (DAYS) | 362 440 145 350 | 439 471 488 482 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.154 P=0.491N P=0.106 P=0.305 | P=0.008N** P=0.045N* P=0.089N P=0.002N** |
|INCIDENTAL TUMOR | P=0.543N P=0.368 P=0.315 P=0.515 | P=0.046N* P=0.301N P=0.207N P=0.031N* |
|LOGISTIC REGRESSION | P=0.543N P=0.328 P=0.271 P=0.503 | P=0.028N* P=0.254N P=0.098N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.439N | P=0.030N* |
|FISHER EXACT | P=0.298 P=0.298 P=0.598N | P=0.243N P=0.100N P=0.036N* |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).