TDMS Study 88034-04 Pathology Tables
NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 5| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| | 6| 3| 7| 4| 5| 6| 7| 5| 5| 6| 7| 5| 4| 1| 8| 7| 7| 7| 3| 8| 5| 5| 5| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 4 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X | Clear Cell Focus | | Degeneration, Fatty | | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | | Necrosis | | __________________________________________________________________________| Mesentery | + + + + + + + | Artery, Inflammation, Chronic Active | | Fat, Necrosis | 2 2 3 2 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hypertrophy | 3 | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 | Mineralization | | Artery, Inflammation, Chronic Active | | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 5| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| | 6| 3| 7| 4| 5| 6| 7| 5| 5| 6| 7| 5| 4| 1| 8| 7| 7| 7| 3| 8| 5| 5| 5| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + M + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 3 3 3 2 3 2 2 1 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + M + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 3 1 2 3 4 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Decidual Reaction | | Hydrometra | 3 4 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + | Iliac, Angiectasis | 3 | Iliac, Hematopoietic Cell | | Proliferation | | Iliac, Hemorrhage | | Iliac, Infiltration Cellular, | | Histiocyte | | Lumbar, Infiltration Cellular, | | Histiocyte | | Renal, Hematopoietic Cell | | Proliferation | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| Hematopoietic Cell Proliferation | | Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | | Hemorrhage | 3 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 5| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| | 6| 3| 7| 4| 5| 6| 7| 5| 5| 6| 7| 5| 4| 1| 8| 7| 7| 7| 3| 8| 5| 5| 5| 3| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + M + M + + + + + + + M + + + + + M M + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 3 3 3 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Mast Cell | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | 3 | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 1 1 1 1 1 | Lateral Wall, Metaplasia, Squamous | | Olfactory Epithelium, Atrophy | 3 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 | Infarct | 3 | Nephropathy | 1 2 1 2 1 2 2 1 1 1 1 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 3| 0| 0| 6| 3| 3| 1| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| | | 9| 7| 1| 0| 7| 6| 6| 1| 5| 7| 7| 6| 9| 7| 6| 7| 6| 8| 6| 1| 5| 4| 6| 9| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + A + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 1 4.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | | 1 | Clear Cell Focus | X | 1 | Degeneration, Fatty | 3 | 1 3.0| Eosinophilic Focus | X X | 3 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + | 11 | Artery, Inflammation, Chronic Active | 3 | 1 3.0| Fat, Necrosis | 2 | 7 2.3| __________________________________________________________________________|____________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 2.0| Hypertrophy | | 1 3.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 2 1.5| __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 | 6 1.2| Mineralization | 2 | 1 2.0| Artery, Inflammation, Chronic Active | 2 | 1 2.0| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 3| 0| 0| 6| 3| 3| 1| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| | | 9| 7| 1| 0| 7| 6| 6| 1| 5| 7| 7| 6| 9| 7| 6| 7| 6| 8| 6| 1| 5| 4| 6| 9| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| Vacuolization Cytoplasmic | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + M + + + + M| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 4 1 | 11 2.4| Pars Intermedia, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 1| 8 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 3 | 2 3.0| Cyst | 3 2 2 2 1| 11 2.4| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Decidual Reaction | 2 | 1 2.0| Hydrometra | | 4 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + | 9 | Iliac, Angiectasis | | 1 3.0| Iliac, Hematopoietic Cell | | | Proliferation | 4 | 1 4.0| Iliac, Hemorrhage | 3 | 1 3.0| Iliac, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| Lumbar, Infiltration Cellular, | | | Histiocyte | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 3| 0| 0| 6| 3| 3| 1| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| | | 9| 7| 1| 0| 7| 6| 6| 1| 5| 7| 7| 6| 9| 7| 6| 7| 6| 8| 6| 1| 5| 4| 6| 9| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Hematopoietic Cell | | | Proliferation | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + + + + + +| 47 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 4 | 1 4.0| Hemorrhage | 1 | 2 2.0| Inflammation, Chronic Active | 3 | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + M M + + + + + + + + + + M + + + +| 41 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Hematopoietic Cell Proliferation | 3 3 4 1 3| 11 2.7| Hyperplasia, Lymphoid | 3 | 2 3.0| Hyperplasia, Mast Cell | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 | 2 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion, Chronic | | 1 3.0| Thrombosis | | 1 2.0| Alveolar Epithelium, Hyperplasia | 3 | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 6| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 5| 5| 7| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 4| 3| 0| 0| 6| 3| 3| 1| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| | | 9| 7| 1| 0| 7| 6| 6| 1| 5| 7| 7| 6| 9| 7| 6| 7| 6| 8| 6| 1| 5| 4| 6| 9| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lateral Wall, Degeneration, Hyaline | | 5 1.0| Lateral Wall, Metaplasia, Squamous | 1 | 1 1.0| Olfactory Epithelium, Atrophy | 2 | 4 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | | 1 3.0| Infarct | | 1 3.0| Nephropathy | 2 1 1 1 1 1 2 1 1 1 1| 25 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 8| 3| 0| 3| 3| 9| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| | 5| 7| 1| 6| 6| 1| 6| 8| 6| 7| 4| 6| 3| 5| 7| 5| 3| 5| 7| 7| 6| 1| 6| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | I + + + + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X | Eosinophilic Focus | X X| Hematopoietic Cell Proliferation | 3 | Necrosis | 2 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + | Fat, Inflammation, Chronic | | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | __________________________________________________________________________| Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X | Hyperplasia, Squamous | 3 | Inflammation, Acute | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 1 1 | Necrosis | 2 | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 1 1 1 1 | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1| Hypertrophy | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + M + M + M + M + M M + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 8| 3| 0| 3| 3| 9| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| | 5| 7| 1| 6| 6| 1| 6| 8| 6| 7| 4| 6| 3| 5| 7| 5| 3| 5| 7| 7| 6| 1| 6| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cyst | | Pars Distalis, Hyperplasia | 2 2 3 1 2 2 3| Pars Intermedia, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 1 2 1 2 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 2 4 2 3 2 | Thrombosis | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M M + + + M M + + + + M + M + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M M M + + + + M + M M + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| Angiectasis | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M M + + + + + + M + + M + + + + M + + + +| Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 4 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Meninges, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 5| 6| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 8| 3| 0| 3| 3| 9| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| | 5| 7| 1| 6| 6| 1| 6| 8| 6| 7| 4| 6| 3| 5| 7| 5| 3| 5| 7| 7| 6| 1| 6| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | 2 | Alveolar Epithelium, Hyperplasia | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 1 1 1 1 | Lateral Wall, Fibrosis | 1 | Lateral Wall, Inflammation, | | Suppurative | 1 1| Lateral Wall, Metaplasia, Squamous | 1 | Olfactory Epithelium, Atrophy | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 1 1 1 4 1 1 1 1 1 1 2 1 1 1 1 2| Renal Tubule, Necrosis | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 5| 6| 7| 2| 6| 6| 7| 3| 5| 6| 7| 7| 5| 7| 7| 1| 5| 6| 7| 5| 1| 5| 7| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + M + + + M + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + I I + I + + + + + + + + + I + + + + I +| 43 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X | 2 | Clear Cell Focus | | 1 | Eosinophilic Focus | X | 3 | Hematopoietic Cell Proliferation | | 1 3.0| Necrosis | 2 | 2 2.0| Centrilobular, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Fat, Inflammation, Chronic | 2 | 1 2.0| Fat, Necrosis | 3 | 3 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | | 1 | Hyperplasia, Squamous | | 1 3.0| Inflammation, Acute | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 2 1 1 1| 8 1.4| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | | 8 1.1| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 4 1.5| Hypertrophy | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 5| 6| 7| 2| 6| 6| 7| 3| 5| 6| 7| 7| 5| 7| 7| 1| 5| 6| 7| 5| 1| 5| 7| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + M + + M M M M + + + + + + + + +| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Pars Distalis, Hyperplasia | 3 2 1 1 2 2 2| 14 2.0| Pars Intermedia, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 2 1 1 1 2 1 1| 19 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 2 1 4 2| 12 2.5| Thrombosis | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 3 | 2 2.5| Hydrometra | 3 4 2 3 1 3 3 | 8 2.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M + M + + + + + + + + M + M + + + + + + + +| 39 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + M + + + + + + M + + M + + + + + + + + +| 39 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + M + + + M + +| 42 | Infiltration Cellular, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 3 3 3 | 6 3.2| Hyperplasia, Lymphoid | 2| 2 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 3| 3| | | 5| 6| 7| 2| 6| 6| 7| 3| 5| 6| 7| 7| 5| 7| 7| 1| 5| 6| 7| 5| 1| 5| 7| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 1 2.0| Meninges, Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion, Chronic | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lateral Wall, Degeneration, Hyaline | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 18 1.0| Lateral Wall, Fibrosis | 1 1 | 3 1.0| Lateral Wall, Inflammation, | | | Suppurative | 1 1 1 | 5 1.0| Lateral Wall, Metaplasia, Squamous | | 1 1.0| Olfactory Epithelium, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.2| Renal Tubule, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 0| 3| 7| 0| 2| 9| 3| 2| 3| 3| | 7| 6| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 5| 9| 7| 9| 6| 8| 9| 8| 3| 6| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + A + + + M + + A + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + I + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + A + + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | | Clear Cell Focus | | Cyst | | Degeneration, Fatty | 2 | Eosinophilic Focus | X | Hematopoietic Cell Proliferation | | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Fatty | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| Mineralization | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| Mineralization | 2 1 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia | 1 2 1 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + M + + M + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + I +| Pars Distalis, Hyperplasia | 2 3 1 2 3 3 1 2 3 2 | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 0| 3| 7| 0| 2| 9| 3| 2| 3| 3| | 7| 6| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 5| 9| 7| 9| 6| 8| 9| 8| 3| 6| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Intermedia, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 3 1 1 3 3 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + A + + + + + + + + + + +| Angiectasis | 3 | Cyst | 2 3 3 | Hyperplasia, Tubular | 2 | Thrombosis | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 2 3 | Inflammation, Suppurative | | Necrosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Iliac, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + M + + M + + + + + + + + + M M M + + + + I| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M M + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + M + M M + + M + + + + M + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 4 3 2 4 3 | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 0| 3| 7| 0| 2| 9| 3| 2| 3| 3| | 7| 6| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 5| 9| 7| 9| 6| 8| 9| 8| 3| 6| 3| 7| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Inflammation, Chronic | 3| __________________________________________________________________________| Peripheral Nerve | +| __________________________________________________________________________| Spinal Cord | +| Inflammation, Chronic | 3| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia | 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 1 1 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + A + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 3 3 3 3 3 3 3 3 2 3 2 3 3 3 3 2 3 3 3 2 3 2 2 3| Lateral Wall, Fibrosis | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2| Lateral Wall, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 3 2| Lateral Wall, Inflammation, | | Suppurative | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 1 2 2 2 1| Lateral Wall, Metaplasia, Squamous | 2 1 1 2 1 2 2 | Olfactory Epithelium, Atrophy | 1 1 2 1 2 1 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 1| | DAY ON TEST | 3| 4| 0| 2| 3| 3| 8| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 4| | | 6| 4| 4| 7| 6| 5| 8| 7| 6| 7| 5| 6| 7| 5| 6| 5| 7| 5| 7| 6| 5| 6| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + A| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + M + + + + + + + + I + + + M + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + A + + A| 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + A| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + A| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Basophilic Focus | X X | 2 | Clear Cell Focus | X X | 2 | Cyst | 3 | 1 3.0| Degeneration, Fatty | | 1 2.0| Eosinophilic Focus | X X X X | 5 | Hematopoietic Cell Proliferation | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + | 4 | Fat, Necrosis | 4 3 2 | 3 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Cyst | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Degeneration, Fatty | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Mineralization | 1 1 | 6 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 | 5 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Hematopoietic Cell Proliferation | 3 | 1 3.0| Hyperplasia | 1 1 1 2 | 7 1.3| Vacuolization Cytoplasmic | 4| 1 4.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 1| | DAY ON TEST | 3| 4| 0| 2| 3| 3| 8| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 4| | | 6| 4| 4| 7| 6| 5| 8| 7| 6| 7| 5| 6| 7| 5| 6| 5| 7| 5| 7| 6| 5| 6| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + M + M + + + M + + + + + + M + + + + A + M +| 40 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + M + + +| 47 | Pars Distalis, Hyperplasia | 2 2 3 1 1 3 2 2 1 1 | 20 2.0| Pars Intermedia, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | Follicular Cell, Hyperplasia | 1 1 1 3 2 2 1 2 2 1 1 2 2 | 21 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + + + + + M + M + M + + M + + +| 45 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Angiectasis | 4 | 2 3.5| Cyst | 3 2 1 1 2 2 2 2 4 3 | 13 2.3| Hyperplasia, Tubular | | 1 2.0| Thrombosis | | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Angiectasis | 4 | 1 4.0| Hydrometra | 3 | 3 2.7| Inflammation, Suppurative | 4 | 1 4.0| Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Iliac, Infiltration Cellular, Plasma | | | Cell | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + A + + M| 40 | Infiltration Cellular, Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + M + + + + + M + + + + + M + + M| 43 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + M + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + M + + M + + + + + + + + M + M + + +| 39 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Hematopoietic Cell Proliferation | 4 4 2 4 | 10 3.2| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + + + M + + M + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 1| | DAY ON TEST | 3| 4| 0| 2| 3| 3| 8| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 4| | | 6| 4| 4| 7| 6| 5| 8| 7| 6| 7| 5| 6| 7| 5| 6| 5| 7| 5| 7| 6| 5| 6| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Prepuce, Inflammation, Chronic Active| 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Meninges, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | Inflammation, Chronic | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | Alveolar Epithelium, Hyperplasia | | 1 1.0| Alveolar Epithelium, Metaplasia | 1 2 2 2 1 1 2 2 1 2 2 1 1 2 2 2 1 1 1 1 1 1 | 43 1.5| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 1 1 | 11 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | Lateral Wall, Degeneration, Hyaline | 3 3 3 3 2 2 3 2 2 3 2 3 2 3 3 3 2 2 2 2 3 2 3 3| 48 2.6| Lateral Wall, Fibrosis | 2 2 1 1 2 1 1 2 1 2 2 2 2 3 3 2 1 1 2 3 2 1 2 | 46 1.8| Lateral Wall, Hyperplasia | 1 1 1 3 1 1 2 1 2 2 3 3 3 2 2 1 1 2 1 2 | 42 1.9| Lateral Wall, Inflammation, | | | Suppurative | 2 1 1 1 2 2 2 2 1 2 2 2 2 2 2 2 1 1 1 2 1 1 2 2| 46 1.7| Lateral Wall, Metaplasia, Squamous | 1 1 1 2 | 11 1.5| Olfactory Epithelium, Atrophy | 2 2 1 2 1 2 | 14 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | Infarct | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 1| | DAY ON TEST | 3| 4| 0| 2| 3| 3| 8| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 4| | | 6| 4| 4| 7| 6| 5| 8| 7| 6| 7| 5| 6| 7| 5| 6| 5| 7| 5| 7| 6| 5| 6| 5| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| | 7| 5| 6| 5| 7| 6| 6| 6| 7| 7| 6| 5| 7| 5| 7| 5| 5| 2| 6| 1| 6| 5| 5| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | I I + + I + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Necrosis | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | | Necrosis | 3 | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Basophilic Focus | X| Hypertrophy | 2 | Lipomatosis | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Acute | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 2 1| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypertrophy | 1 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + M + + M M + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 3 1 3 1 2 1 2| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| | 7| 5| 6| 5| 7| 6| 6| 6| 7| 7| 6| 5| 7| 5| 7| 5| 5| 2| 6| 1| 6| 5| 5| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 3 2 2 2 1 1 1 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + M + M + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 2 1 3 3 1 3 | Inflammation, Suppurative | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hydrometra | 3 3 | Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | __________________________________________________________________________| Lymph Node, Bronchial | M M + + + M M + + + + + M + + + M + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + M + + + +| Angiectasis | 2 | Hemorrhage | | __________________________________________________________________________| Lymph Node, Mediastinal | + M + + + + + + M + + + + + + M M + + + + M + M +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 4 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| | 7| 5| 6| 5| 7| 6| 6| 6| 7| 7| 6| 5| 7| 5| 7| 5| 5| 2| 6| 1| 6| 5| 5| 5| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Epiglottis, Hyperplasia | 1 1 1 | Epiglottis, Metaplasia, Squamous | 1 1 1 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 2 2 | Alveolar Epithelium, Metaplasia | 3 3 3 2 3 2 3 2 3 3 2 2 2 2 2 2 3 3 2 3 3 3 2 3| Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 2 2 2 1 2 2 2 1 1 2 2 2 1 2 2 1 2 2 2 2 2| Bronchiole, Hyperplasia | 1 | Bronchiole, Necrosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Hyperplasia | 3 | Lateral Wall, Degeneration, Hyaline | 4 4 4 3 3 4 4 3 4 4 4 4 3 4 4 4 4 2 3 3 3 3 3 4 4| Lateral Wall, Fibrosis | 3 2 3 3 3 2 2 1 3 3 3 2 2 3 2 3 3 3 3 3 3 3 2 3 3| Lateral Wall, Hyperplasia | 3 3 3 3 3 3 2 1 3 3 3 3 3 2 2 3 3 2 2 3 2 2 2 3 3| Lateral Wall, Inflammation, | | Suppurative | 3 3 2 2 3 3 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2| Lateral Wall, Metaplasia, Squamous | 1 3 2 3 2 2 2 2 2 1 1 1 1 3 2 1| Olfactory Epithelium, Atrophy | 2 2 2 2 1 2 2 2 2 2 3 1 1 2 2 2 1 2 3 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Inflammation, Chronic Active | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 1 | Nephropathy | 1 1 1 2 2 1 1 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 1| 3| 3| 8| 3| 8| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 6| 3| 3| | | 5| 5| 6| 6| 4| 5| 5| 5| 6| 8| 6| 6| 6| 5| 7| 0| 5| 5| 7| 5| 7| 5| 9| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + + + I| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 | Inflammation, Acute | 3 | 1 3.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 1 3.0| Eosinophilic Focus | X | 4 | Hepatodiaphragmatic Nodule | X | 1 | Necrosis | | 1 3.0| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Basophilic Focus | | 1 | Hypertrophy | | 1 2.0| Lipomatosis | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 2 3 3 | 3 2.7| Inflammation, Acute | 2 2 2 1 | 5 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 3 1.3| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 4 | 5 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 1 | 3 1.3| Hypertrophy | 2 1| 4 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 1| 3| 3| 8| 3| 8| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 6| 3| 3| | | 5| 5| 6| 6| 4| 5| 5| 5| 6| 8| 6| 6| 6| 5| 7| 0| 5| 5| 7| 5| 7| 5| 9| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + M + + + + + + + + + M + + + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 2 1 2 3 3 2 2 | 17 2.0| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 2 2 2 2 2 1 1 1 2 1 1 3| 25 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 2 | 11 2.4| Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 2.0| Hydrometra | 3 | 3 3.0| Inflammation, Suppurative | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + | 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + M + + + + M + + + + + + + + + + + + + +| 42 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + + + + + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Angiectasis | | 1 2.0| Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M M + + + M + + + M M M + + M + + M + M +| 35 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 | 3 3.3| Hyperplasia, Lymphoid | 2 | 2 2.0| __________________________________________________________________________|____________| Thymus | + + + + + M + M + + + + + + M + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 1| 3| 3| 8| 3| 8| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 6| 3| 3| | | 5| 5| 6| 6| 4| 5| 5| 5| 6| 8| 6| 6| 6| 5| 7| 0| 5| 5| 7| 5| 7| 5| 9| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 1.0| Epiglottis, Hyperplasia | 1 1 1 1 | 7 1.0| Epiglottis, Metaplasia, Squamous | | 4 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | | 2 2.0| Alveolar Epithelium, Metaplasia | 2 2 3 2 2 2 3 2 3 2 3 3 3 2 3 1 3 3 3 3 3 3 3 3 3| 49 2.6| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 2 2 2 2 1 2 2 1 2 2 1 2 2 1 2 2 3| 42 1.8| Bronchiole, Hyperplasia | 2 | 2 1.5| Bronchiole, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glands, Hyperplasia | | 1 3.0| Lateral Wall, Degeneration, Hyaline | 4 3 4 3 4 3 4 4 4 4 4 4 4 3 4 3 3 3 3 3 4 3 4 3 3| 50 3.5| Lateral Wall, Fibrosis | 3 3 3 3 2 3 3 3 3 2 3 3 2 3 3 1 2 3 2 3 2 3 3 3 3| 50 2.7| Lateral Wall, Hyperplasia | 3 3 3 3 3 2 2 3 2 3 2 2 2 2 2 3 2 3 3 3 2 3 2 2 2| 50 2.5| Lateral Wall, Inflammation, | | | Suppurative | 2 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 1 2| 50 2.1| Lateral Wall, Metaplasia, Squamous | 1 3 1 3 3 2 3 2 3 3 2 2 2 2 3 3 3 3 2 3| 36 2.2| Olfactory Epithelium, Atrophy | 2 2 2 2 2 2 2 2 1 2 2 1 2 2 1 2 2 1 1 2 1| 41 1.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 2 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 1| 3| 3| 8| 3| 8| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 6| 3| 3| | | 5| 5| 6| 6| 4| 5| 5| 5| 6| 8| 6| 6| 6| 5| 7| 0| 5| 5| 7| 5| 7| 5| 9| 7| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Infarct | | 1 1.0| Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 26 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 4| 6| 4| 3| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 3| 3| 3| 3| 0| 6| 4| 0| 8| 6| 9| 3| 3| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| | 1| 3| 4| 4| 4| 2| 7| 6| 8| 4| 2| 5| 4| 4| 3| 4| 3| 5| 4| 4| 1| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + I + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Infiltration Cellular,| | Plasma Cell | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X X X X | Cyst | 2 | Eosinophilic Focus | | Fibrosis | | Necrosis | 4 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Inflammation, Acute | 2 | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 1 1 1 | Inflammation, Chronic Active | | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 | Hypertrophy | 2 2 1 2 3 2 2 2 2 1 1 1| Capsule, Hyperplasia | 3 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 4| 6| 4| 3| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 3| 3| 3| 3| 0| 6| 4| 0| 8| 6| 9| 3| 3| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| | 1| 3| 4| 4| 4| 2| 7| 6| 8| 4| 2| 5| 4| 4| 3| 4| 3| 5| 4| 4| 1| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 3 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 3 1 1 3 4 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Artery, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 | Mineralization | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Necrosis | | __________________________________________________________________________| Lymph Node | + + | Iliac, Infiltration Cellular, Plasma | | Cell | 3 | Renal, Infiltration Cellular, Plasma | | Cell | 3 | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + + + + M + + M + M + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + M + + + + + + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + M + + + + + M M + + M + + + + + + M + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 | Necrosis | | __________________________________________________________________________| Thymus | M M + + + + + + M + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 6| 4| 6| 4| 3| 6| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 3| 3| 3| 3| 0| 6| 4| 0| 8| 6| 9| 3| 3| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| | 1| 3| 4| 4| 4| 2| 7| 6| 8| 4| 2| 5| 4| 4| 3| 4| 3| 5| 4| 4| 1| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3 | Prepuce, Inflammation, Chronic Active| 4 3 4 3 4 4 | Subcutaneous Tissue, Inflammation, | | Granulomatous | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Inflammation, Chronic Active | 2 1 | Artery, Inflammation, Chronic Active | 3 | Epiglottis, Hyperplasia | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Thrombosis | 1 | Alveolar Epithelium, Hyperplasia | 2 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Lateral Wall, Degeneration, Hyaline | | Olfactory Epithelium, Atrophy | | Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Infarct | 2 2 | Nephropathy | 1 1 1 2 2 1 2 1 2 1 2 1 2 2 1 1 1 1 1 1 3 2| Papilla, Inflammation, Suppurative | 2 2 2 | Pelvis, Dilatation | 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 4 4 4 | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 4| 1| 3| 4| 0| 3| 3| | | 3| 3| 3| 4| 3| 6| 9| 3| 4| 3| 4| 4| 3| 4| 3| 3| 9| 1| 4| 2| 3| 4| 5| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + A + + + + M + + + + + + + + + + + + + M + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Peyer's Patch, Infiltration Cellular,| | | Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | | 4 | Cyst | | 1 2.0| Eosinophilic Focus | X | 1 | Fibrosis | 3 | 1 3.0| Necrosis | 2 4 | 3 3.3| __________________________________________________________________________|____________| Mesentery | + +| 4 | Fat, Necrosis | 2 2| 3 2.0| __________________________________________________________________________|____________| Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | | 1 2.0| Inflammation, Acute | 2 2 | 3 2.0| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 | 8 1.4| Inflammation, Chronic Active | 3 | 1 3.0| Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 1 1 2 2 2 1 2 2 2 | 14 1.7| Hypertrophy | 1 2 1 2 2 1 1 2 1 2 1 1 2 1| 26 1.6| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 4| 1| 3| 4| 0| 3| 3| | | 3| 3| 3| 4| 3| 6| 9| 3| 4| 3| 4| 4| 3| 4| 3| 3| 9| 1| 4| 2| 3| 4| 5| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Capsule, Hyperplasia | 3 | 3 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + M + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + A + + + + M + + + + + + + + I + + + + + + + + +| 47 | Cyst | 2 | 1 2.0| Pars Distalis, Hyperplasia | 2 2 2 3 | 5 2.2| __________________________________________________________________________|____________| Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Hyperplasia | 2| 6 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 3 3 3 3 3 3 | 12 2.8| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Inflammation, Suppurative | 2 | 1 2.0| Artery, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 | 4 1.5| Mineralization | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 | 1 2.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + | 4 | Iliac, Infiltration Cellular, Plasma | | | Cell | | 1 3.0| Renal, Infiltration Cellular, Plasma | | | Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + A M M + + M + + M + + + + + + + M + + + + + + +| 40 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 4| 1| 3| 4| 0| 3| 3| | | 3| 3| 3| 4| 3| 6| 9| 3| 4| 3| 4| 4| 3| 4| 3| 3| 9| 1| 4| 2| 3| 4| 5| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + M M M M + + + + + + + M M| 41 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + M + + +| 48 | Angiectasis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M A + + + + + M + + + + + + + + + + M + + + + + +| 40 | __________________________________________________________________________|____________| Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | | 2 3.0| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + A + + + M M + + M + + + + + + + + M + + M + M +| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 3.0| Prepuce, Inflammation, Chronic Active| 2 2 | 8 3.3| Subcutaneous Tissue, Inflammation, | | | Granulomatous | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 | 1 1.0| Inflammation, Chronic Active | 1 1| 4 1.3| Artery, Inflammation, Chronic Active | | 1 3.0| Epiglottis, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Thrombosis | | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 4 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 | 2 1.0| Lateral Wall, Degeneration, Hyaline | 1 1 | 2 1.0| Olfactory Epithelium, Atrophy | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 5| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 4| 1| 3| 4| 0| 3| 3| | | 3| 3| 3| 4| 3| 6| 9| 3| 4| 3| 4| 4| 3| 4| 3| 3| 9| 1| 4| 2| 3| 4| 5| 3| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Olfactory Epithelium, Metaplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 3.0| Infarct | 4 | 3 2.7| Nephropathy | 1 2 2 2 1 1 2 1 1 2 2 2 1 1 2 2 2 1 2 2 1| 43 1.5| Papilla, Inflammation, Suppurative | 2 1 2 | 6 1.8| Pelvis, Dilatation | 3 | 3 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4 4 | 6 3.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| DAY ON TEST | 3| 8| 9| 1| 3| 2| 3| 3| 3| 6| 4| 3| 3| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 0| 3| | 3| 1| 6| 2| 3| 7| 4| 4| 3| 7| 5| 4| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + I + + + + + A + +| Degeneration, Hyaline | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X | Eosinophilic Focus | X | Inflammation, Chronic Active | 3 | Karyomegaly | 3 | Mineralization | | Necrosis | | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 2 | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Basophilic Focus | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hyperplasia, Squamous | | Inflammation, Acute | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Hypertrophy | 2 2 2 2 2 2 1 2 2 2 1 2 3| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| DAY ON TEST | 3| 8| 9| 1| 3| 2| 3| 3| 3| 6| 4| 3| 3| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 0| 3| | 3| 1| 6| 2| 3| 7| 4| 4| 3| 7| 5| 4| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + | Iliac, Infiltration Cellular, Plasma | | Cell | 4 | Inguinal, Infiltration Cellular, | | Plasma Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + M M + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + M + + + + + + M + M + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 3 3 | __________________________________________________________________________| Thymus | + M + + + + + + + M M + + + + M + + M + M M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| 4 4 4 4 4 4 | Subcutaneous Tissue, Inflammation, | | Granulomatous | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 5| 7| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| DAY ON TEST | 3| 8| 9| 1| 3| 2| 3| 3| 3| 6| 4| 3| 3| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 0| 3| | 3| 1| 6| 2| 3| 7| 4| 4| 3| 7| 5| 4| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 0| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 2 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 4 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 2 | Lateral Wall, Inflammation, | | Suppurative | 1 1 1 1 1 1 | Lateral Wall, Metaplasia, Squamous | 2 2 1 | Nasopharyngeal Duct, Inflammation, | | Chronic Active | 3 | Olfactory Epithelium, Atrophy | 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Harderian Gland | + + + | Hyperplasia | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Infarct | | Metaplasia, Osseous | 1 | Nephropathy | 2 1 1 4 2 1 2 2 2 1 1 2 1 1 2 1 2 1| Papilla, Inflammation, Suppurative | 4 3 | Pelvis, Dilatation | 3 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 4 | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| | | 0| 3| 4| 9| 4| 3| 4| 4| 3| 3| 7| 4| 4| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + M + + + + + + + + + + + + + + + + M + + + + +| 46 | Degeneration, Hyaline | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X| 2 | Clear Cell Focus | X X X | 4 | Eosinophilic Focus | X | 2 | Inflammation, Chronic Active | | 1 3.0| Karyomegaly | | 1 3.0| Mineralization | 2 | 1 2.0| Necrosis | 2 | 1 2.0| Centrilobular, Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + + | 5 | Inflammation, Chronic Active | | 1 2.0| Fat, Necrosis | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Basophilic Focus | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Hyperplasia, Squamous | 2 | 1 2.0| Inflammation, Acute | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 1 1 1 1 1 1 2| 18 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| | | 0| 3| 4| 9| 4| 3| 4| 4| 3| 3| 7| 4| 4| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Hyperplasia | 2 2 2 1 2 2 2 1 | 9 1.8| Hypertrophy | 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2| 31 1.9| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 1 2 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 2 1 1 1 | 8 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 3 3 | 2 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 4 2.8| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 3 | 2 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + | 6 | Iliac, Infiltration Cellular, Plasma | | | Cell | | 1 4.0| Inguinal, Infiltration Cellular, | | | Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + M + + M + M| 43 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + M + M + + + +| 43 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + + + + M + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 3 3.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| 42 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| | | 0| 3| 4| 9| 4| 3| 4| 4| 3| 3| 7| 4| 4| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| | 6 4.0| Subcutaneous Tissue, Inflammation, | | | Granulomatous | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Meninges, Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1| 13 1.1| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | 3 3 1 2 | 6 2.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lateral Wall, Degeneration, Hyaline | | 1 2.0| Lateral Wall, Inflammation, | | | Suppurative | 1 1 | 8 1.0| Lateral Wall, Metaplasia, Squamous | | 3 1.7| Nasopharyngeal Duct, Inflammation, | | | Chronic Active | | 1 3.0| Olfactory Epithelium, Atrophy | | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 2 | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + + + + + | 8 | Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| | DAY ON TEST | 4| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| | | 0| 3| 4| 9| 4| 3| 4| 4| 3| 3| 7| 4| 4| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Infarct | 2 | 1 2.0| Metaplasia, Osseous | | 1 1.0| Nephropathy | 1 1 1 2 2 1 2 1 2 1 2 2 1 2 1 2 2 1 2 1 2 1| 40 1.6| Papilla, Inflammation, Suppurative | 3 | 3 3.3| Pelvis, Dilatation | 2 2 | 4 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 3 3.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 5| 4| 7| 4| 1| 6| 5| 7| 6| 7| 7| 5| 4| 7| 7| 7| 5| 7| 7| 5| DAY ON TEST | 3| 3| 3| 6| 3| 5| 8| 3| 8| 4| 5| 4| 3| 4| 3| 3| 8| 8| 3| 3| 3| 8| 3| 3| 2| | 4| 4| 4| 4| 3| 9| 9| 4| 4| 5| 3| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3| 4| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X | Degeneration, Fatty | | Fibrosis | 3 | Hematopoietic Cell Proliferation | 2 | Necrosis | 2 | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 1 | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hyperplasia | 1 1 1 | Hypertrophy | 2 1 1 1 1 2 2 1 1 2 2 1 | Capsule, Hyperplasia | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Cyst | | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 5| 4| 7| 4| 1| 6| 5| 7| 6| 7| 7| 5| 4| 7| 7| 7| 5| 7| 7| 5| DAY ON TEST | 3| 3| 3| 6| 3| 5| 8| 3| 8| 4| 5| 4| 3| 4| 3| 3| 8| 8| 3| 3| 3| 8| 3| 3| 2| | 4| 4| 4| 4| 3| 9| 9| 4| 4| 5| 3| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3| 4| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Penis | + + | Inflammation, Acute | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 3| __________________________________________________________________________| Prostate | + + + + + + + + M + + M + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Interstitial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Iliac, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + M M + M + + + + M + + M M + M + + + + + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + M + M + + M M + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M M + + + + + + + + + + + M + + M| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Hematopoietic Cell Proliferation | 3 3 | __________________________________________________________________________| Thymus | + + M + M + + + + + M + + + + + + + + M + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| 3 3 4 4 4 4 3| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 5| 4| 7| 4| 1| 6| 5| 7| 6| 7| 7| 5| 4| 7| 7| 7| 5| 7| 7| 5| DAY ON TEST | 3| 3| 3| 6| 3| 5| 8| 3| 8| 4| 5| 4| 3| 4| 3| 3| 8| 8| 3| 3| 3| 8| 3| 3| 2| | 4| 4| 4| 4| 3| 9| 9| 4| 4| 5| 3| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3| 4| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Fibrosis | | Hemorrhage | 3 | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia | 2 1 1 2 1 2 1 1 1 2 2 2 1 2 2 2 1 1 2 3 1 1 2| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 2 2 2 3 3 2 3 2 3 1 1 1 1 2 1 2 2 3 2 3 2 2 2 3 2| Lateral Wall, Fibrosis | 1 1 2 2 2 3 1 2 2 1 1 1 2 1 1 2 2 1 3 2 2 2 2 1| Lateral Wall, Hyperplasia | 2 1 1 2 3 1 2 2 2 1 1 2 2 2 2 1 1 2 2 2 2 1 1| Lateral Wall, Inflammation, | | Suppurative | 2 1 1 2 2 2 2 3 2 1 1 1 1 2 1 2 1 1 2 2 2 2 1| Lateral Wall, Metaplasia, Squamous | 1 1 | Olfactory Epithelium, Atrophy | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, | | Polymorphonuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Infarct | 2 | Nephropathy | 2 2 2 2 2 2 2 1 2 1 2 1 1 2 1 2 1 2 2 2 1 1| Papilla, Inflammation, Suppurative | 3 1 3 3 3 4 | Pelvis, Dilatation | 3 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 3 4 3 2 | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 4| 7| 5| | DAY ON TEST | 3| 3| 2| 8| 3| 6| 6| 0| 2| 3| 3| 3| 3| 9| 3| 8| 3| 5| 3| 3| 0| 3| 6| 3| 9| | | 3| 4| 1| 1| 4| 0| 5| 9| 7| 4| 3| 4| 4| 6| 4| 3| 3| 9| 3| 4| 1| 0| 1| 4| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + A + + + + + + +| 48 | Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | X | 2 | Degeneration, Fatty | 1 | 1 1.0| Fibrosis | | 1 3.0| Hematopoietic Cell Proliferation | | 1 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | | 1 1.0| __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 1 2 | 11 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Hyperplasia | 1 1 2 2 2 2 1 1 1| 12 1.3| Hypertrophy | 1 2 2 1 1 2 2 1 1 1 | 22 1.4| Capsule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 4| 7| 5| | DAY ON TEST | 3| 3| 2| 8| 3| 6| 6| 0| 2| 3| 3| 3| 3| 9| 3| 8| 3| 5| 3| 3| 0| 3| 6| 3| 9| | | 3| 4| 1| 1| 4| 0| 5| 9| 7| 4| 3| 4| 4| 6| 4| 3| 3| 9| 3| 4| 1| 0| 1| 4| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Cyst | 1 | 1 1.0| Pars Distalis, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Hyperplasia | 1 1 1 1 1 | 10 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 1 | 1 1.0| __________________________________________________________________________|____________| Penis | | 2 | Inflammation, Acute | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Inflammation, Chronic Active | 3 2 3 3 3 | 6 2.8| __________________________________________________________________________|____________| Prostate | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 | Inflammation, Suppurative | 3 | 2 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Interstitial Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + | 3 | Iliac, Infiltration Cellular, Plasma | | | Cell | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + + + + M M M + + + + + + + + M + + + + +| 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + M + + + +| 41 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + M + + + + M M + + + M + + + + M + M| 39 | __________________________________________________________________________|____________| Spleen | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 3.0| Hematopoietic Cell Proliferation | 2 | 3 2.7| __________________________________________________________________________|____________| Thymus | + + + M + + + + M + M + M + + M + I M + M + + + +| 37 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M + M M M M M M| 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 4| 7| 5| | DAY ON TEST | 3| 3| 2| 8| 3| 6| 6| 0| 2| 3| 3| 3| 3| 9| 3| 8| 3| 5| 3| 3| 0| 3| 6| 3| 9| | | 3| 4| 1| 1| 4| 0| 5| 9| 7| 4| 3| 4| 4| 6| 4| 3| 3| 9| 3| 4| 1| 0| 1| 4| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| 4 3 4 4 4 | 12 3.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 1 | 4 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 | 1 1.0| Hemorrhage | | 1 3.0| Alveolar Epithelium, Hyperplasia | 1 3 | 2 2.0| Alveolar Epithelium, Metaplasia | 2 1 2 2 2 1 1 1 1 1 2 2 2 2 2 1 2 2 2 2 2 1 1 2 1| 48 1.6| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 2 1 1 1 1 | 18 1.1| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lateral Wall, Degeneration, Hyaline | 2 2 3 2 3 2 1 1 1 1 1 2 2 3 2 2 2 2 2 2 1 2 3 2 | 49 2.0| Lateral Wall, Fibrosis | 1 2 2 2 1 1 2 2 1 2 1 2 2 3 2 1 1 1 2 2 1 1 2 | 47 1.6| Lateral Wall, Hyperplasia | 1 2 1 1 1 2 1 1 1 2 2 3 1 2 1 1 1 2 3 | 42 1.6| Lateral Wall, Inflammation, | | | Suppurative | 1 2 1 2 1 1 1 1 1 1 2 2 2 2 1 1 1 2 3 | 42 1.5| Lateral Wall, Metaplasia, Squamous | 1 | 3 1.0| Olfactory Epithelium, Atrophy | 1 2 | 3 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, | | | Polymorphonuclear | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + | 6 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Infarct | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 4| 6| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 4| 7| 5| | DAY ON TEST | 3| 3| 2| 8| 3| 6| 6| 0| 2| 3| 3| 3| 3| 9| 3| 8| 3| 5| 3| 3| 0| 3| 6| 3| 9| | | 3| 4| 1| 1| 4| 0| 5| 9| 7| 4| 3| 4| 4| 6| 4| 3| 3| 9| 3| 4| 1| 0| 1| 4| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy | 1 1 1 1 1 1 2 3 1 1 2 2 2 1 1 1 2 2 1 2 1 1 1 1| 46 1.5| Papilla, Inflammation, Suppurative | 3 2 | 8 2.8| Pelvis, Dilatation | 3 | 4 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 4 3 | 8 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 3| 7| 6| 4| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 7| 5| 4| 7| 0| 7| 7| 6| 4| 7| DAY ON TEST | 5| 3| 1| 6| 3| 3| 3| 3| 6| 3| 5| 1| 0| 3| 3| 0| 2| 4| 3| 8| 3| 3| 1| 8| 3| | 0| 4| 2| 2| 3| 4| 4| 3| 7| 3| 1| 4| 2| 3| 3| 9| 5| 6| 3| 0| 3| 4| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Clear Cell Focus | | Eosinophilic Focus | | Centrilobular, Necrosis | 3 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 1 1 1 2 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 1 | Hypertrophy | 1 1 1 2 1 2 2 2 1 2 2 2| Capsule, Hyperplasia | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Follicular Cell, Hyperplasia | 1 1 1 1 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 3| 7| 6| 4| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 7| 5| 4| 7| 0| 7| 7| 6| 4| 7| DAY ON TEST | 5| 3| 1| 6| 3| 3| 3| 3| 6| 3| 5| 1| 0| 3| 3| 0| 2| 4| 3| 8| 3| 3| 1| 8| 3| | 0| 4| 2| 2| 3| 4| 4| 3| 7| 3| 1| 4| 2| 3| 3| 9| 5| 6| 3| 0| 3| 4| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + | Inflammation, Acute | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Necrosis | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 3 2 | Mineralization | 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + | Iliac, Infiltration Cellular, Plasma | | Cell | 2 3 3 | Renal, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + M + + M + + + + + + + M + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + M + + + M + + + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| Angiectasis | | Hemorrhage | 1 | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + M + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Prepuce, Inflammation, Chronic Active| 4 4 2 2 4 4 4 4 3 | Subcutaneous Tissue, Fibrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 _____________________________________________________________________________________________________________________ | 3| 7| 6| 4| 7| 7| 7| 7| 5| 7| 5| 5| 6| 7| 7| 7| 5| 4| 7| 0| 7| 7| 6| 4| 7| DAY ON TEST | 5| 3| 1| 6| 3| 3| 3| 3| 6| 3| 5| 1| 0| 3| 3| 0| 2| 4| 3| 8| 3| 3| 1| 8| 3| | 0| 4| 2| 2| 3| 4| 4| 3| 7| 3| 1| 4| 2| 3| 3| 9| 5| 6| 3| 0| 3| 4| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 1 1 1 1| Epiglottis, Hyperplasia | 1 1 1 | Epiglottis, Metaplasia, Squamous | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Alveolar Epithelium, Hyperplasia | 4 | Alveolar Epithelium, Metaplasia | 3 3 3 2 2 3 3 3 3 3 3 3 2 2 2 3 3 2 1 2 3 2 2 3 2| Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 1 2 2 2 2 2 1 1| Bronchiole, Erosion | 3 | Bronchiole, Hyperplasia | | Bronchiole, Necrosis | 1 3 | Bronchus, Erosion | 3 | Bronchus, Necrosis | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lateral Wall, Degeneration, Hyaline | 3 4 4 3 4 4 4 4 3 4 3 2 3 3 3 4 4 4 4 2 4 4 4 4 4| Lateral Wall, Fibrosis | 2 2 3 3 3 3 3 3 2 3 3 2 3 3 3 3 3 2 2 3 3 3 2 3| Lateral Wall, Hyperplasia | 3 2 1 2 2 2 2 2 2 2 3 2 2 2 2 1 3 3 2 2 3 3 2 2 2| Lateral Wall, Inflammation, | | Suppurative | 2 3 2 2 2 3 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2| Lateral Wall, Metaplasia, Squamous | 2 2 3 1 1 1 1 2 1 2 2 1 2 3 2 1 2 1 2 2 | Olfactory Epithelium, Atrophy | 2 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Metaplasia, Osseous | | Nephropathy | 2 1 2 2 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1| Papilla, Inflammation, Suppurative | 1 3 3 2 2 | Pelvis, Dilatation | 2 3 2 | __________________________________________________________________________| Urethra | + + | Inflammation, Suppurative | | Bulbourethral Gland, Inflammation, | | Suppurative | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Chronic Active | 4 3 3 4 | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 6| 3| 5| 7| 5| 6| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 3| 6| 8| 9| 3| 9| 8| 3| 1| 3| 3| 5| | | 4| 4| 3| 4| 4| 3| 3| 7| 4| 4| 6| 3| 3| 0| 5| 0| 5| 3| 2| 1| 3| 6| 3| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Clear Cell Focus | X | 1 | Eosinophilic Focus | X X | 2 | Centrilobular, Necrosis | 3 | 2 3.0| __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Necrosis | 2 | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | + | 1 | Developmental Malformation | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 1 1 1 1 1 | 17 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 1 2 1 1 1 2 | 15 1.7| Hypertrophy | 2 3 2 1 1 2 1 1 2 2 | 22 1.6| Capsule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 1 | 3 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + M +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 3 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 6| 3| 5| 7| 5| 6| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 3| 6| 8| 9| 3| 9| 8| 3| 1| 3| 3| 5| | | 4| 4| 3| 4| 4| 3| 3| 7| 4| 4| 6| 3| 3| 0| 5| 0| 5| 3| 2| 1| 3| 6| 3| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Hyperplasia | 2 2 2 1 2 1 1 2 2 2 2| 17 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | | 1 | Inflammation, Acute | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 2| 2 1.5| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 3 | 2 2.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 4 2.0| Mineralization | 3 | 3 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + | 10 | Iliac, Infiltration Cellular, Plasma | | | Cell | 3 3 3 3 | 7 2.9| Renal, Infiltration Cellular, Plasma | | | Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + + + + M + + M + + + + + + M M M + M| 38 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M M + M + M + + M + + M M + + M + + + +| 38 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 3 | 1 3.0| Hemorrhage | 1 | 2 1.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + + + M + + + + M + + + M + + + + + +| 45 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 3 2 | 6 2.3| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + M + M + + + M + M + + M + + +| 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M| 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 6| 3| 5| 7| 5| 6| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 3| 6| 8| 9| 3| 9| 8| 3| 1| 3| 3| 5| | | 4| 4| 3| 4| 4| 3| 3| 7| 4| 4| 6| 3| 3| 0| 5| 0| 5| 3| 2| 1| 3| 6| 3| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Prepuce, Inflammation, Chronic Active| 3 4 4 3 3 4 4 3 4 4 3 | 20 3.5| Subcutaneous Tissue, Fibrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 1 2 1 | 9 1.2| Epiglottis, Hyperplasia | 1 1 1 | 6 1.0| Epiglottis, Metaplasia, Squamous | 1 1 | 2 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 4 | 3 3.3| Alveolar Epithelium, Metaplasia | 3 2 1 2 3 2 3 3 2 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 3| 50 2.6| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 2 2 2 3 1 1 2 1 2 2 2 2 2 2 2 2 2 2 1| 31 1.8| Bronchiole, Erosion | | 1 3.0| Bronchiole, Hyperplasia | 2 | 1 2.0| Bronchiole, Necrosis | 1 | 3 1.7| Bronchus, Erosion | | 1 3.0| Bronchus, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lateral Wall, Degeneration, Hyaline | 4 4 3 4 4 4 4 3 4 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 3| 50 3.7| Lateral Wall, Fibrosis | 3 2 2 3 3 3 3 3 3 3 1 3 3 3 3 2 2 3 2 3 3 3 3 3 2| 49 2.7| Lateral Wall, Hyperplasia | 2 2 2 3 3 2 3 1 3 3 3 2 3 3 3 2 2 2 3 2 2 2 2 2 2| 50 2.3| Lateral Wall, Inflammation, | | | Suppurative | 2 2 2 2 3 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2| 50 2.1| Lateral Wall, Metaplasia, Squamous | 2 1 1 2 1 2 2 1 1 1 2 3 1 3 3 1| 36 1.7| Olfactory Epithelium, Atrophy | 1 2 2 1 2 1 2 2 | 11 1.6| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 88034-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 6| 3| 5| 7| 5| 6| 7| 6| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 0| 3| 3| 3| 6| 8| 9| 3| 9| 8| 3| 1| 3| 3| 5| | | 4| 4| 3| 4| 4| 3| 3| 7| 4| 4| 6| 3| 3| 0| 5| 0| 5| 3| 2| 1| 3| 6| 3| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 2 3 4 2 4 | 6 2.8| Metaplasia, Osseous | 1 1 2 1 | 4 1.3| Nephropathy | 2 2 1 2 1 1 1 1 2 2 1 2 2 2 1 2 2 2 | 37 1.5| Papilla, Inflammation, Suppurative | 2 2 2 3 4 2 1 3 3 | 14 2.4| Pelvis, Dilatation | 3 | 4 2.5| __________________________________________________________________________|____________| Urethra | + | 3 | Inflammation, Suppurative | 4 | 1 4.0| Bulbourethral Gland, Inflammation, | | | Suppurative | 3 | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 4 4 3 4 4 4 4 3 4 | 13 3.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------