TDMS Study 88034-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 05/08/95
EXP: 88034 OZONE TIME: 20:53:46
TEST: 04 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: C88034
CONT: N01-ES-95239 CAS: 10028-15-6
PATHOLOGIST: S. GRUMBEIN
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 05/08/95
EXP: 88034 OZONE TIME: 20:53:46
TEST: 04 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: C88034
CONT: N01-ES-95239 CAS: 10028-15-6
PATHOLOGIST: S. GRUMBEIN
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 205 362 446 453 484 525 596 602 608 609 |
| 611 612 644 644 653 667 681 695 701 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.12 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 440 459 527 540 545 551 567 596 600 612 |
| 637 667 681 695 695 699 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 145 460 461 464 484 484 489 522 527 544 |
| 559 583 583 583 596 596 621 630 644 653 |
| 659 665 681 701 709 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 80 350 380 446 462 484 506 514 525 551 |
| 557 567 592 595 602 612 612 616 630 658 |
| 665 681 709 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 96.0 96.0 90.0 88.0 84.0 70.0 60.0 |
| | |
| | |
|0.12 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 90.0 82.0 78.0 68.0 |
| | |
| | |
|0.5 PPM | 100.0 98.0 98.0 98.0 98.0 88.0 80.0 68.0 56.0 50.0 |
| | |
| | |
|1.0 PPM | 98.0 98.0 98.0 96.0 94.0 88.0 82.0 70.0 58.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 68.0% 50.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.157 P=0.519N P=0.329 P=0.515 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 576.4 594.4 561.7 538.9 |
|NATURAL DEATHS (C) | (29.0) (20.5) (23.3) (28.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 670.3 688.7 647.4 643.7 |
|(STANDARD ERROR) | (15.8) (11.2) (16.8) (18.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 439 511 531 538 544 566 601 634 636 638 |
| 649 653 667 667 681 689 694 700 723 723 |
| 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.12 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 471 471 567 594 608 612 653 681 681 681 |
| 687 703 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 2 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 527 574 634 644 646 659 667 677 678 693 |
| 704 709 709 723 728 |
| CENSORED DEATHS |
| 146 488 |
| |
==================================================================================
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 482 488 514 516 540 569 611 667 685 685 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 86.0 76.0 58.0 |
| | |
| | |
|0.12 PPM | 100.0 100.0 100.0 100.0 100.0 96.0 96.0 92.0 86.0 74.0 |
| | |
| | |
|0.5 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 97.9 95.8 87.5 68.8 |
| | |
| | |
|1.0 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 88.0 86.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 74.0% 68.8% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.089N P=0.134N P=0.276N P=0.045N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 629.1 625.5 664.8 575.7 |
|NATURAL DEATHS (C) | (17.4) (22.9) (14.3) (25.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 690.5 706.5 697.2 703.1 |
|(STANDARD ERROR) | (10.4) ( 9.0) (13.6) (10.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OZONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.12 PPM = 2
0.5 PPM = 3
1.0 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 4 3 1 2
| 4 3 1 4 1 2 2
96 + 4 1 4 1 2 2
| 4 1 133 2 2
P | 4 143 1
E | 4 1 1 22
R 88 + 4 4 1 2 2 1
C | 3 44 3 2 2
E | 4 33 11
N | 43 34 2 2
T 80 + 343 11 2
| 34 3 2 2
S | 4 4 1 1 2 2
U | 2 2
R 72 + 3 43 1 1
V | 4 4 1 1
I | 3 3 1 1 2 2
V | 33 1 1
A 64 + 4 3 3 11
L | 4 3 3 1 1
| 3 3 1
| 4 4
56 + 3 3 4
| 3 34 4
| 33
| 3 3
48 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.
OZONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.12 PPM = 2
0.5 PPM = 3
1.0 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 24 3
|
| 1 44 1 3 3
| 2 4 14 1 23 3
95 +
| 11 2 2 33
| 4 11 2 2
| 33
90 + 1 14 22 3 3
|
P | 14 1 2 2 33
E | 1 4 1 2 4 2
R 85 + 33
C | 4 4
E | 11
N | 3 3
T 80 + 11 22 4
| 3 3
S | 11 2 23
U | 1 1 2 2
R 75 +
V | 2 2
I | 1 1 3 3
V |
A 70 + 11
L | 3 3
| 11
|
65 +
| 1 1
|
|
60 +
|
| 1 1
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.