TDMS Study 88034-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
OZONE
NTP Experiment-Test: 88034-03 Report: PEIRPT03
Study Type: CHRONIC Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 56 56 56 56
Scheduled Sacrifice 6 6 6 6
Early Deaths
Moribund Sacrifice 19 22 17 16
Natural Death 3 4 3 7
Survivors
Terminal Sacrifice 28 24 30 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (49)
Cyst 1 (2%)
Parasite Metazoan 2 (4%) 2 (4%) 3 (6%) 5 (10%)
Intestine Large, Rectum (43) (48) (45) (48)
Parasite Metazoan 4 (9%) 4 (8%) 3 (7%) 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Parasite Metazoan 4 (8%) 2 (4%) 8 (16%) 9 (18%)
Intestine Small, Duodenum (50) (50) (50) (49)
Parasite Metazoan 1 (2%)
Intestine Small, Ileum (50) (49) (48) (47)
Parasite Metazoan 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 4 (8%)
Basophilic Focus 38 (76%) 34 (68%) 35 (70%) 38 (76%)
Clear Cell Focus 6 (12%) 5 (10%) 5 (10%) 4 (8%)
Degeneration, Fatty 13 (26%) 6 (12%) 8 (16%) 4 (8%)
Eosinophilic Focus 3 (6%) 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 7 (14%) 6 (12%) 6 (12%) 15 (30%)
Mixed Cell Focus 5 (10%) 13 (26%) 6 (12%) 7 (14%)
Necrosis 1 (2%) 1 (2%)
Regeneration 1 (2%)
Bile Duct, Hyperplasia 10 (20%) 11 (22%) 8 (16%) 11 (22%)
Centrilobular, Necrosis 2 (4%) 4 (8%) 3 (6%) 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (4) (5) (11) (4)
Hemorrhage 1 (25%)
Artery, Inflammation, Chronic Active 1 (25%) 1 (9%) 1 (25%)
Artery, Mineralization 1 (25%)
Fat, Necrosis 2 (50%) 5 (100%) 9 (82%) 3 (75%)
Oral Mucosa (1) (1)
Pharyngeal, Hyperplasia 1 (100%)
Pancreas (50) (50) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 22 (44%) 14 (28%) 18 (36%) 20 (41%)
Basophilic Focus 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Artery, Inflammation 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Duct, Metaplasia, Squamous 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Mineralization 2 (4%)
Necrosis 2 (4%) 4 (8%) 4 (8%) 3 (6%)
Stomach, Glandular (50) (50) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 5 (10%) 4 (8%) 5 (10%) 7 (14%)
Necrosis 4 (8%) 2 (4%) 2 (4%)
Tongue (1) (1) (1)
Hyperplasia 1 (100%)
Tooth (1) (1) (1)
Developmental Malformation 1 (100%) 1 (100%) 1 (100%)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 37 (74%) 32 (64%) 34 (68%) 30 (60%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 21 (42%) 22 (44%) 22 (44%) 23 (46%)
Hypertrophy 12 (24%) 13 (26%) 9 (18%) 7 (14%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 2 (4%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 9 (18%) 10 (20%) 11 (22%) 5 (10%)
Parathyroid Gland (49) (48) (46) (49)
Hyperplasia 3 (6%) 1 (2%) 3 (7%) 1 (2%)
Pituitary Gland (50) (49) (50) (49)
Cyst 5 (10%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 13 (26%) 8 (16%) 7 (14%) 10 (20%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 43 (86%) 38 (76%) 34 (68%) 31 (62%)
Follicular Cell, Hyperplasia 2 (4%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (50) (47) (47)
Cyst 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Chronic Active 3 (6%) 2 (4%) 4 (9%)
Ovary (50) (50) (49) (49)
Angiectasis 1 (2%)
Cyst 1 (2%) 2 (4%) 11 (22%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Granulomatous 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%) 2 (4%) 4 (8%)
Lymph Node (5) (9) (3) (3)
Renal, Hemorrhage 1 (11%) 1 (33%)
Renal, Inflammation, Granulomatous 1 (11%) 1 (33%)
Lymph Node, Mandibular (48) (47) (46) (46)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (50) (49) (50)
Hemorrhage 1 (2%) 1 (2%)
Lymph Node, Mediastinal (39) (46) (41) (47)
Hemorrhage 1 (3%) 1 (2%)
Spleen (50) (50) (50) (49)
Fibrosis 2 (4%) 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
Capsule, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (50)
Galactocele 2 (4%)
Hyperplasia, Atypical 4 (8%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Skin (50) (50) (50) (50)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Prepuce, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Hyperostosis 3 (6%) 2 (4%) 6 (12%) 6 (12%)
Skeletal Muscle (1) (3)
Cyst 1 (33%)
Hemorrhage 1 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Meninges, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Epiglottis, Metaplasia, Squamous 4 (8%) 5 (10%) 9 (18%) 43 (86%)
Lung (50) (50) (50) (50)
Inflammation, Chronic Active 5 (10%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Mineralization 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 5 (10%) 5 (10%) 6 (12%)
Alveolar Epithelium, Metaplasia 6 (12%) 48 (96%) 48 (96%)
Alveolus, Infiltration Cellular, Histiocyte 31 (62%) 43 (86%)
Artery, Mediastinum, Mineralization 1 (2%)
Interstitium, Fibrosis 42 (84%) 47 (94%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 3 (6%) 6 (12%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Thrombosis 6 (12%) 3 (6%) 4 (8%) 3 (6%)
Goblet Cell, Lateral Wall, Hyperplasia 1 (2%) 2 (4%) 45 (90%) 50 (100%)
Lateral Wall, Hyperplasia 2 (4%) 8 (16%) 48 (96%) 50 (100%)
Lateral Wall, Metaplasia, Squamous 2 (4%) 11 (22%) 21 (42%) 45 (90%)
Nasopharyngeal Duct, Inflammation, Acute 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 50 (100%) 48 (96%) 50 (100%) 47 (94%)
Olfactory Epithelium, Metaplasia 3 (6%)
Trachea (50) (50) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Cataract 2 (100%)
Degeneration 1 (100%)
Retina, Atrophy 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Mineralization 1 (2%)
Nephropathy 49 (98%) 48 (96%) 48 (96%) 46 (92%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (50) (49) (49) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 56 56 56 56
Scheduled Sacrifice 6 6 6 6
Early Deaths
Moribund Sacrifice 35 40 36 36
Natural Death 6 5 7 7
Accidently Killed 1
Survivors
Terminal Sacrifice 8 5 7 7
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%)
Parasite Metazoan 3 (6%) 4 (8%) 9 (18%) 6 (12%)
Intestine Large, Rectum (50) (50) (50) (49)
Mineralization 1 (2%)
Parasite Metazoan 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Intestine Large, Cecum (50) (50) (49) (50)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 3 (6%) 5 (10%) 3 (6%) 5 (10%)
Intestine Small, Duodenum (50) (50) (50) (49)
Hyperplasia, Adenomatous 1 (2%)
Necrosis 1 (2%) 3 (6%) 1 (2%)
Intestine Small, Ileum (50) (50) (49) (48)
Inflammation, Acute 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 4 (8%) 1 (2%) 2 (4%) 4 (8%)
Basophilic Focus 14 (28%) 18 (36%) 11 (22%) 9 (18%)
Clear Cell Focus 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Degeneration, Cystic 13 (26%) 16 (32%) 19 (38%) 14 (28%)
Degeneration, Fatty 9 (18%) 5 (10%) 5 (10%) 4 (8%)
Eosinophilic Focus 1 (2%) 4 (8%) 2 (4%) 2 (4%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 5 (10%) 2 (4%) 4 (8%)
Inflammation, Granulomatous 2 (4%)
Mineralization 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%) 4 (8%) 1 (2%)
Necrosis 2 (4%) 3 (6%) 1 (2%)
Regeneration 2 (4%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 29 (58%) 34 (68%) 37 (74%) 33 (66%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 3 (6%) 6 (12%) 3 (6%) 2 (4%)
Mesentery (12) (6) (12) (8)
Thrombosis 1 (8%)
Artery, Inflammation, Chronic Active 1 (8%) 1 (8%)
Artery, Mineralization 3 (25%) 2 (33%) 1 (8%) 1 (13%)
Fat, Necrosis 7 (58%) 4 (67%) 9 (75%) 5 (63%)
Pancreas (50) (50) (50) (50)
Atrophy 22 (44%) 23 (46%) 30 (60%) 26 (52%)
Basophilic Focus 1 (2%) 4 (8%)
Hyperplasia 2 (4%) 4 (8%) 4 (8%) 2 (4%)
Thrombosis 1 (2%)
Artery, Inflammation 3 (6%) 1 (2%) 1 (2%)
Artery, Mineralization 2 (4%)
Salivary Glands (49) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 2 (4%)
Foreign Body 1 (2%)
Hyperplasia, Squamous 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Inflammation, Acute 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Mineralization 2 (4%) 5 (10%) 1 (2%) 4 (8%)
Necrosis 4 (8%) 7 (14%) 9 (18%) 7 (14%)
Stomach, Glandular (50) (50) (50) (50)
Cyst 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Mineralization 6 (12%) 7 (14%) 7 (14%) 10 (20%)
Necrosis 2 (4%) 4 (8%) 3 (6%) 3 (6%)
Tooth (2) (2) (1) (2)
Developmental Malformation 2 (100%) 2 (100%)
Inflammation, Chronic Active 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (4) (4) (1) (2)
Aorta, Mineralization 4 (100%) 4 (100%) 1 (100%) 2 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 39 (78%) 37 (74%) 44 (88%) 36 (72%)
Mineralization 1 (2%) 2 (4%)
Thrombosis 2 (4%)
Artery, Mineralization 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Atrium, Thrombosis 2 (4%) 3 (6%) 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Hyperplasia 24 (48%) 20 (40%) 23 (46%) 18 (36%)
Hypertrophy 6 (12%) 7 (14%) 7 (14%) 7 (14%)
Necrosis 2 (4%) 2 (4%) 2 (4%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 23 (46%) 29 (58%) 24 (48%) 17 (34%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 2 (4%) 1 (2%) 2 (4%)
Parathyroid Gland (49) (49) (48) (47)
Hyperplasia 10 (20%) 10 (20%) 15 (31%) 11 (23%)
Pituitary Gland (50) (50) (49) (49)
Cyst 1 (2%)
Mineralization 2 (4%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 3 (6%) 3 (6%) 5 (10%)
Pars Distalis, Metaplasia, Osseous 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Hyperplasia 29 (59%) 25 (50%) 31 (62%) 16 (32%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Preputial Gland (49) (50) (50) (49)
Cyst 1 (2%)
Inflammation, Chronic Active 4 (8%) 2 (4%) 3 (6%) 6 (12%)
Prostate (49) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 7 (14%) 7 (14%) 5 (10%) 6 (12%)
Inflammation, Suppurative 2 (4%)
Seminal Vesicle (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 10 (20%) 4 (8%) 6 (12%) 6 (12%)
Artery, Inflammation, Chronic Active 7 (14%) 8 (16%) 4 (8%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Interstitial Cell, Hyperplasia 13 (26%) 13 (26%) 13 (26%) 9 (18%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%)
Lymph Node (18) (10) (24) (10)
Iliac, Hemorrhage 1 (6%)
Renal, Angiectasis 1 (6%)
Renal, Hemorrhage 6 (33%) 2 (20%) 6 (25%) 1 (10%)
Renal, Inflammation, Granulomatous 1 (4%)
Lymph Node, Bronchial (43) (38) (44) (38)
Fibrosis 1 (3%)
Hemorrhage 1 (2%)
Lymph Node, Mandibular (46) (46) (46) (42)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 2 (4%) 2 (4%) 2 (5%)
Lymph Node, Mesenteric (49) (49) (50) (50)
Ectasia 1 (2%)
Hemorrhage 1 (2%)
Lymph Node, Mediastinal (46) (47) (48) (46)
Hemorrhage 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 12 (24%) 11 (22%) 16 (32%) 14 (28%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 1 (2%)
Necrosis 2 (4%) 5 (10%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (33) (29) (28) (30)
Galactocele 2 (6%) 1 (3%) 1 (4%) 1 (3%)
Skin (50) (50) (50) (50)
Hyperkeratosis 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 8 (16%) 2 (4%) 1 (2%)
Prepuce, Inflammation, Acute 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 7 (14%) 8 (16%) 8 (16%) 4 (8%)
Hyperostosis 1 (2%) 1 (2%)
Skeletal Muscle (2) (2) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 2 (4%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 2 (4%) 16 (32%) 43 (86%)
Lung (50) (50) (50) (50)
Congestion, Chronic 1 (2%)
Hemorrhage 2 (4%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%) 1 (2%)
Mineralization 3 (6%) 4 (8%) 1 (2%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 6 (12%) 6 (12%) 3 (6%) 4 (8%)
Alveolar Epithelium, Metaplasia 9 (18%) 46 (92%) 47 (94%)
Alveolus, Edema 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 27 (54%) 42 (84%)
Artery, Infiltration Cellular, Histiocyte 1 (2%)
Artery, Mediastinum, Inflammation 1 (2%)
Artery, Mediastinum, Mineralization 5 (10%) 3 (6%) 1 (2%) 2 (4%)
Bronchiole, Necrosis 1 (2%)
Interstitium, Fibrosis 2 (4%) 40 (80%) 44 (88%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 3 (6%) 10 (20%) 12 (24%) 20 (40%)
Thrombosis 8 (16%) 13 (26%) 12 (24%) 8 (16%)
Goblet Cell, Lateral Wall, Hyperplasia 1 (2%) 4 (8%) 41 (82%) 48 (96%)
Lateral Wall, Hyperplasia 8 (16%) 50 (100%) 49 (98%)
Lateral Wall, Metaplasia, Squamous 2 (4%) 6 (12%) 36 (72%) 46 (92%)
Olfactory Epithelium, Degeneration, Hyaline 50 (100%) 50 (100%) 50 (100%) 50 (100%)
Olfactory Epithelium, Metaplasia 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Trachea (50) (50) (50) (50)
Inflammation, Acute 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%) 1 (2%)
Mineralization 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (2)
Cataract 2 (67%) 2 (100%)
Degeneration 1 (100%)
Hemorrhage 1 (33%)
Cornea, Inflammation, Chronic Active 1 (50%)
Cornea, Mineralization 1 (33%)
Retina, Atrophy 2 (67%) 1 (50%)
Zymbal's Gland (1) (1) (1)
Hyperplasia, Squamous 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Angiectasis 1 (2%)
Cyst 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Infarct 1 (2%) 2 (4%) 1 (2%)
Mineralization 4 (8%) 5 (10%) 1 (2%) 2 (4%)
Nephropathy 49 (98%) 48 (96%) 50 (100%) 50 (100%)
Thrombosis 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute 2 (4%) 3 (6%) 4 (8%) 2 (4%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic Active 1 (2%) 3 (6%) 4 (8%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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