TDMS Study 88034-03 Pathology Tables
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + + + + + + + + M + + M + + + + M + +| Adenoma | X X X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Arrhenoblastoma Malignant | X | Granulosa Cell Tumor Benign | | Histiocytic Sarcoma | X| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X | Polyp Stromal, Multiple | | Sarcoma Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + +| Iliac, Histiocytic Sarcoma | X| Lumbar, Leukemia Mononuclear | X | Pancreatic, Histiocytic Sarcoma | X| Pancreatic, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + M + + + + + M M + + M + + M + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + M + + + + + M + + M + M + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + + M + M + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | I + + + + + + + + + + + + I I + I + I + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + M + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Arrhenoblastoma Malignant | | Granulosa Cell Tumor Benign | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | Polyp Stromal, Multiple | X X | Sarcoma Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | | Iliac, Histiocytic Sarcoma | | Lumbar, Leukemia Mononuclear | | Pancreatic, Histiocytic Sarcoma | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + +| Hemangiosarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + M M + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + + + + M + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + I + + | 43 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + | 50 | __________________________________________________________________________|____________| Liver | + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 17 | __________________________________________________________________________|____________| Mesentery | | 4 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + | 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + | 50 | Carcinoma | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + | 50 | Leukemia Mononuclear | | 7 | Pheochromocytoma Benign | | 5 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + | 50 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 7 | Pars Distalis, Adenoma | X X | 34 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 50 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | | 4 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + | 43 | Adenoma | | 5 | __________________________________________________________________________|____________| Ovary | + + + + | 50 | Arrhenoblastoma Malignant | | 1 | Granulosa Cell Tumor Benign | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Uterus | + + + + | 50 | Polyp Stromal | | 8 | Polyp Stromal, Multiple | | 2 | Sarcoma Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Lymph Node | | 5 | Iliac, Histiocytic Sarcoma | | 1 | Lumbar, Leukemia Mononuclear | | 1 | Pancreatic, Histiocytic Sarcoma | | 1 | Pancreatic, Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + | 43 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + | 48 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 49 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | X | 11 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + | 39 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 8 | __________________________________________________________________________|____________| Spleen | + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 17 | __________________________________________________________________________|____________| Thymus | + + + + | 45 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + | 50 | Adenoma | | 1 | Carcinoma | X | 4 | Fibroadenoma | X | 18 | Fibroadenoma, Multiple | X | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + | 50 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lung | + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 14 | __________________________________________________________________________|____________| Nose | + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Trachea | + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 50 | Leukemia Mononuclear | X | 13 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Granulosa-Theca Tumor Malignant | | Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X X X| Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + | Carcinoma, Metastatic, Thyroid Gland | | Deep Cervical, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + M M M + M M + + + + + + + + +| Leukemia Mononuclear | X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + M + + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + M + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Thymus | + + + M + + + + + + + + M + + + + + M + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Fibroadenoma | X X X X X| Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Subcutaneous Tissue, Lipoma | | Subcutaneous Tissue, Melanoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | Carcinoma, Metastatic, Adrenal Cortex| | Leukemia Mononuclear | X X X X X X X X| Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + I + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | Leukemia Mononuclear | X| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | Granulosa-Theca Tumor Malignant | X | Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Polyp Stromal | X X X X X X | Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Lymph Node | + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Deep Cervical, Leukemia Mononuclear | X X| Pancreatic, Leukemia Mononuclear | X X X X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + M + M + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + M + + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X| Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + M + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M| Adenoma | | Carcinoma | | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Lipoma | | Subcutaneous Tissue, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Carcinoma, Metastatic, Adrenal Cortex| | Leukemia Mononuclear | X X X X X X X| Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + I | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Mesentery | | 5 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + | 50 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Adenoma | | 1 | Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Leukemia Mononuclear | X | 6 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Adenoma | | 1 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 49 | Leukemia Mononuclear | X | 8 | Pars Distalis, Adenoma | X X X | 36 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | C-Cell, Adenoma | X X | 5 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 50 | Adenoma | X | 3 | Carcinoma | | 3 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + | 50 | Granulosa Cell Tumor Malignant | | 1 | Granulosa-Theca Tumor Malignant | | 1 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + | 50 | Leukemia Mononuclear | | 2 | Polyp Stromal | X | 11 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Lymph Node | + | 9 | Carcinoma, Metastatic, Thyroid Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Deep Cervical, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | X | 5 | Renal, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + | 39 | Leukemia Mononuclear | | 8 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 47 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | | 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 50 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 46 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X | 11 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Thymus | + M + M + | 43 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 49 | Adenoma | | 1 | Carcinoma | X | 1 | Fibroadenoma | X | 12 | Fibroadenoma, Multiple | | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Lipoma | X | 1 | Subcutaneous Tissue, Melanoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | __________________________________________________________________________|____________| Lung | + + + + + | 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Carcinoma, Metastatic, Adrenal Cortex| X | 1 | Leukemia Mononuclear | X X | 17 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + | 50 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Leukemia Mononuclear | X X | 10 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 49 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 50 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + I + + + + + + + + + I + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Sarcoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | X X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + I + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Histiocytic Sarcoma | X | Bilateral, Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X | Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | + + | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + M + + M + M + + + + + + + + M + + + M| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + M M + M +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X | Mesothelioma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | M M + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X X X X X X X X X| Fibroadenoma, Multiple | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Histiocytic | | Sarcoma | X | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Glands, Adenoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + I + I + + + + + + + + + + + + + + + I +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Mesentery | + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Sarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Benign | X| Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +| Adenoma | X X X X| Carcinoma | X | Histiocytic Sarcoma | | Bilateral, Adenoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + M + + + + + + + + + +| Granulosa Cell Tumor Malignant | X | Leukemia Mononuclear | X X X | Mesothelioma Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | | Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + M + + M M + + + + + + + + + M| Leukemia Mononuclear | X X | Mesothelioma Malignant | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + M +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M M M + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Histiocytic | | Sarcoma | | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Glands, Adenoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 48 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 16 | __________________________________________________________________________|____________| Mesentery | + | 11 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Leukemia Mononuclear | | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Adenoma | | 2 | Leukemia Mononuclear | | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Leukemia Mononuclear | | 10 | Pheochromocytoma Benign | X X | 5 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Leukemia Mononuclear | | 6 | Pars Distalis, Adenoma | X X X X X X | 38 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Adenoma | | 5 | C-Cell, Carcinoma | | 2 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + | 47 | Adenoma | X X | 7 | Carcinoma | | 3 | Histiocytic Sarcoma | | 1 | Bilateral, Adenoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + | 49 | Granulosa Cell Tumor Malignant | | 1 | Leukemia Mononuclear | | 8 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + | 49 | Leukemia Mononuclear | | 2 | Polyp Stromal | X X | 7 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 11 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Iliac, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | | 2 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M M + | 36 | Leukemia Mononuclear | | 8 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 12 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | Leukemia Mononuclear | | 11 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + + + | 41 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 11 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Leukemia Mononuclear | | 16 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Thymus | + M + + + + | 46 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 50 | Adenoma | | 1 | Carcinoma | | 3 | Fibroadenoma | X X X | 22 | Fibroadenoma, Multiple | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Leukemia Mononuclear | | 6 | Glands, Adenoma | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 49 | Leukemia Mononuclear | | 3 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 16 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + I + + + I + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Squamous Cell Carcinoma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Ganglioneuroma | X | Leukemia Mononuclear | X X | Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + I + + + + + + + + + + + + + + M +| Adenoma | X X X X X X | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | | Polyp Stromal | X | Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node | + | Iliac, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X | Fibroadenoma, Multiple | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Glioma Benign | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | X | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + A + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + A + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Carcinoma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Ganglioneuroma | | Leukemia Mononuclear | X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + A + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | | Polyp Stromal | X X X | Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node | + + | Iliac, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + M + + + M + + + + M + M +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Thymoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X | Fibroadenoma, Multiple | X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Glioma Benign | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + | 47 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + | 47 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 17 | __________________________________________________________________________|____________| Mesentery | | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Leukemia Mononuclear | | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Ganglioneuroma | | 1 | Leukemia Mononuclear | | 4 | Pheochromocytoma Benign | | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + M + + + | 49 | Leukemia Mononuclear | | 7 | Pars Distalis, Adenoma | X X X X | 33 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + | 47 | Adenoma | X | 8 | Carcinoma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + | 50 | Deciduoma Benign | X | 1 | Polyp Stromal | X X | 6 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Lymph Node | | 3 | Iliac, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + | 43 | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + | 46 | Leukemia Mononuclear | | 8 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 50 | Leukemia Mononuclear | | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + + | 47 | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + | 49 | Leukemia Mononuclear | X X | 17 | __________________________________________________________________________|____________| Thymus | + + M + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 5 | Thymoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 50 | Carcinoma | | 1 | Fibroadenoma | X | 8 | Fibroadenoma, Multiple | | 4 | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Basal Cell Adenoma | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 3 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Glioma Benign | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Carcinoma, Metastatic, Mammary Gland | | 1 | Leukemia Mononuclear | | 11 | __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Leukemia Mononuclear | | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + | Mesothelioma Malignant | X | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X| _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X | Interstitial Cell, Adenoma | X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + | Deep Cervical, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | X X | Lumbar, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Bronchial | M + + M M + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + M M| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + M + M + + +| Leukemia Mononuclear | X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | M M + + + + + + + M M + + + + + + M + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + M M M + + + + + + M + M + + M + +| Fibroadenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Keratoacanthoma, Multiple | X | Leukemia Mononuclear | | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Chondrosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + | Squamous Cell Carcinoma, Metastatic, | | Lung | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | Squamous Cell Carcinoma | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Lipoma | X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Mesothelioma Malignant | | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Squamous Cell Carcinoma, Metastatic, | | Lung | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Bilateral, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X | Leukemia Mononuclear | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X | Interstitial Cell, Adenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + M| Leukemia Mononuclear | X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Squamous Cell Carcinoma, Metastatic, | | Lung | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + M M + + + + M + M M + M M +| Fibroadenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Keratoacanthoma, Multiple | | Leukemia Mononuclear | X X | Squamous Cell Carcinoma | | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Chondrosarcoma | | __________________________________________________________________________| Skeletal Muscle | + | Squamous Cell Carcinoma, Metastatic, | | Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | X | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | Squamous Cell Carcinoma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Lipoma | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 50 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Hepatocellular Adenoma | | 2 | Leukemia Mononuclear | X X X | 26 | __________________________________________________________________________|____________| Mesentery | + + + | 12 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 4 | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Leukemia Mononuclear | X X X | 7 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X | 17 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Leukemia Mononuclear | X X X | 15 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 9 | Bilateral, Pheochromocytoma Benign | | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Adenoma | | 4 | Carcinoma | | 3 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + | 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Leukemia Mononuclear | X X X | 13 | Pars Distalis, Adenoma | X X X X | 41 | __________________________________________________________________________|____________| Thyroid Gland | + M + + + + | 49 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 49 | Adenoma | X | 3 | Carcinoma | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Adenoma | X X X | 18 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Leukemia Mononuclear | X X X | 19 | __________________________________________________________________________|____________| Lymph Node | + + | 18 | Deep Cervical, Leukemia Mononuclear | X | 2 | Iliac, Leukemia Mononuclear | X | 3 | Lumbar, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X | 4 | Renal, Leukemia Mononuclear | X | 9 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + | 43 | Leukemia Mononuclear | X X X | 14 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 46 | Leukemia Mononuclear | X X X | 16 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | Leukemia Mononuclear | X X X | 21 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 46 | Leukemia Mononuclear | X X X | 17 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibroma | | 1 | Leukemia Mononuclear | X X X | 27 | __________________________________________________________________________|____________| Thymus | + + + + + + | 44 | Leukemia Mononuclear | X X X | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + M | 33 | Fibroadenoma | | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Keratoacanthoma | | 2 | Keratoacanthoma, Multiple | | 1 | Leukemia Mononuclear | | 2 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Chondrosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | Squamous Cell Carcinoma, Metastatic, | | | Lung | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Glioma Malignant | | 1 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X X X | 23 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Leukemia Mononuclear | X X | 12 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Leukemia Mononuclear | X X X | 23 | Lipoma | | 1 | Renal Tubule, Adenoma | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X | 27 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X X X X X X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X X| Pars Distalis, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X X X X| C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Tunica Vaginalis, Mesothelioma Benign| | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________________________________________| Lymph Node | + + + + + | Pancreatic, Leukemia Mononuclear | X X X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | + M M + M + + + + + + M M + + + + + + + M + + +| Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M M M + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + M + M + + + M + M M + M + M + M M +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X | Leukemia Mononuclear | | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibrosarcoma | X X | Subcutaneous Tissue, Hemangioma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | Renal Tubule, Adenoma | X | Renal Tubule, Adenoma, Multiple | X | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Transitional Epithelium, Carcinoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| Mesothelioma Benign | | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + | Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Mesentery | + | Leukemia Mononuclear | X | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | Adenoma | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Carcinoma | X X | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X | Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | C-Cell, Adenoma | X | C-Cell, Carcinoma | X X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Tunica Vaginalis, Mesothelioma Benign| X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + | Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + | Bilateral, Interstitial Cell, Adenoma| X X X X X | Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + M + + + M + + + + + + + + + M | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + M + + + + + + + + M | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + M + + + + | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + M + M + + + + + | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + M M + M + + + + M M + + M M + + + + | Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + | Basal Cell Adenoma | | Keratoacanthoma | X | Leukemia Mononuclear | X | Squamous Cell Carcinoma | | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangioma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | Renal Tubule, Adenoma | X | Renal Tubule, Adenoma, Multiple | | Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X | Transitional Epithelium, Carcinoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Benign | X | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X | 30 | __________________________________________________________________________|____________| Mesentery | + | 6 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Leukemia Mononuclear | X | 11 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 4 | __________________________________________________________________________|____________| Heart | + + + + + | 50 | Leukemia Mononuclear | X | 13 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Leukemia Mononuclear | X X | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X | 8 | Bilateral, Pheochromocytoma Benign | X | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Adenoma | | 2 | Carcinoma | | 3 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 50 | Leukemia Mononuclear | X X | 15 | Pars Distalis, Adenoma | X X | 43 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X X | 8 | C-Cell, Carcinoma | | 3 | Follicular Cell, Adenoma | X | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | Tunica Vaginalis, Mesothelioma Benign| | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + | 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Penis | | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 50 | Carcinoma | | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + | 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 50 | Leukemia Mononuclear | X | 8 | __________________________________________________________________________|____________| Testes | + + + + + | 50 | Bilateral, Interstitial Cell, Adenoma| X X | 14 | Interstitial Cell, Adenoma | | 9 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | Leukemia Mononuclear | X X | 24 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | Pancreatic, Leukemia Mononuclear | X X | 5 | Renal, Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M | 38 | Leukemia Mononuclear | X | 20 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 46 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 49 | Leukemia Mononuclear | X X | 22 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 47 | Leukemia Mononuclear | X X | 21 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Leukemia Mononuclear | X X X X | 31 | __________________________________________________________________________|____________| Thymus | + + + + M | 43 | Leukemia Mononuclear | X | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M M | 29 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Basal Cell Adenoma | | 1 | Keratoacanthoma | | 2 | Leukemia Mononuclear | X | 2 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | X | 4 | Subcutaneous Tissue, Fibrosarcoma | | 2 | Subcutaneous Tissue, Hemangioma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Leukemia Mononuclear | | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lung | + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X X | 25 | __________________________________________________________________________|____________| Nose | + + + + + | 50 | Leukemia Mononuclear | X | 8 | __________________________________________________________________________|____________| Trachea | + + + + + | 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Leukemia Mononuclear | X X | 23 | Renal Tubule, Adenoma | | 2 | Renal Tubule, Adenoma, Multiple | | 1 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Leukemia Mononuclear | X | 7 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 50 | Leukemia Mononuclear | X X X X | 31 | Mesothelioma Benign | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + A + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + +| Leiomyoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X | Fat, Lipoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X| Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + I + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + +| Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X | Renal, Histiocytic Sarcoma | | Renal, Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + + + + + + + + M + + M M| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Thymoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M + M M M M M M + + M + + M M M + + +| Carcinoma | | Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Thyroid Gland | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Renal Tubule, Adenoma | X | Transitional Epithelium, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X | Fat, Lipoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X X X| Bilateral, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X X X | Pancreatic, Leukemia Mononuclear | X X X X X | Renal, Histiocytic Sarcoma | X | Renal, Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + M + + M + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M + + + M M M M + + + + + M M + M M| Carcinoma | X | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Thyroid Gland | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X | Renal Tubule, Adenoma | X | Transitional Epithelium, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 48 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | Leiomyoma | | 1 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Hepatocellular Adenoma | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 31 | __________________________________________________________________________|____________| Mesentery | + + | 12 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 2 | Fat, Lipoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Leukemia Mononuclear | X | 5 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X X | 23 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Leukemia Mononuclear | X X | 20 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X | 16 | Bilateral, Pheochromocytoma Benign | X | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Adenoma | X | 5 | Carcinoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 49 | Leukemia Mononuclear | X X | 15 | Pars Distalis, Adenoma | X X X X | 42 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | X | 2 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + | 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 50 | Adenoma | X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + | 50 | Adenoma | | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Testes | + + + + + | 50 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X | 16 | Interstitial Cell, Adenoma | X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | Leukemia Mononuclear | X X | 26 | __________________________________________________________________________|____________| Lymph Node | + | 24 | Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | X | 4 | Pancreatic, Leukemia Mononuclear | | 7 | Renal, Histiocytic Sarcoma | | 1 | Renal, Leukemia Mononuclear | X | 10 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + | 44 | Leukemia Mononuclear | X X | 21 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 46 | Leukemia Mononuclear | X X | 13 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 50 | Leukemia Mononuclear | X X | 25 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 48 | Leukemia Mononuclear | X X | 23 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Leukemia Mononuclear | X X | 31 | __________________________________________________________________________|____________| Thymus | M + + + + | 45 | Leukemia Mononuclear | X | 8 | Thymoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M | 28 | Carcinoma | | 1 | Fibroadenoma | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Keratoacanthoma | | 2 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | __________________________________________________________________________|____________| Lung | + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 29 | __________________________________________________________________________|____________| Nose | + + + + + | 50 | Leukemia Mononuclear | X X | 13 | __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Leukemia Mononuclear | X X | 25 | Renal Tubule, Adenoma | | 2 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 31 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X | Mesothelioma Malignant | X| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + + +| Mesothelioma Malignant | X X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X X| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X X| __________________________________________________________________________| Tooth | + | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| Mesothelioma Malignant | X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pheochromocytoma Malignant | X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | X X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Adenoma, Multiple | | Carcinoma | X X | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X| C-Cell, Carcinoma | | Follicular Cell, Adenoma | X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Tunica Vaginalis, Mesothelioma | | Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Benign | X | Mesothelioma Malignant | X X| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | Mesothelioma Malignant | X| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Benign | X | Mesothelioma Malignant | X X| Bilateral, Interstitial Cell, Adenoma| X X X X X X X | Interstitial Cell, Adenoma | X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Lymph Node | + | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | M + M M + M + + M + + + M + + + + + M + + M M +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + + M| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Malignant | X X| __________________________________________________________________________| Thymus | M + + + + + + M + M + + + + + + + + + M + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + M M M + M + + + + M + + + M M +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X | Squamous Cell Papilloma | | Trichoepithelioma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | _____________________________________________________________________________________________________________________| Page 87 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X X| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | Serosa, Mesothelioma Benign | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Mesothelioma Malignant | X| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Benign | X X | Mesothelioma Malignant | X X| _____________________________________________________________________________________________________________________| Page 88 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Mesothelioma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + | Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Mesothelioma Malignant | | __________________________________________________________________________| Tooth | + | Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 89 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pheochromocytoma Malignant | | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | Adenoma | X | Adenoma, Multiple | X | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | M + + + + + + M + + + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + I + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | C-Cell, Adenoma | | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Tunica Vaginalis, Mesothelioma | | Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | Mesothelioma Benign | | Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + M + + + + + + + + | Adenoma | X X | Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | Adenoma | X | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | Mesothelioma Benign | | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + | Pancreatic, Leukemia Mononuclear | X X X X X | Renal, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + M + + M + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + M + + + | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Thymus | M + M M + + M + + + + + + + M + + + + + | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + M + + + M + M + + M M + + + M M | Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | Keratoacanthoma | X X X X | Squamous Cell Papilloma | X | Trichoepithelioma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Skeletal Muscle | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Adenoma, | | Multiple | X | _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X X X X X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | Serosa, Mesothelioma Benign | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X X | Mesothelioma Benign | | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Leukemia Mononuclear | | 2 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 49 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 49 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 48 | Leukemia Mononuclear | | 3 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Hepatocellular Carcinoma | | 1 | Leukemia Mononuclear | X X X | 27 | __________________________________________________________________________|____________| Mesentery | | 8 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Leukemia Mononuclear | | 5 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Leukemia Mononuclear | | 2 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Tooth | | 2 | Odontoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Leukemia Mononuclear | | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 93 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Leukemia Mononuclear | X X | 18 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Leukemia Mononuclear | X | 9 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X X | 7 | Bilateral, Pheochromocytoma Benign | X | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Adenoma | | 5 | Adenoma, Multiple | | 1 | Carcinoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 49 | Leukemia Mononuclear | X | 15 | Pars Distalis, Adenoma | X X X X | 40 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | Tunica Vaginalis, Mesothelioma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 3 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 49 | Adenoma | | 2 | Carcinoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + | 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 94 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X | 22 | Interstitial Cell, Adenoma | X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Leukemia Mononuclear | X X X | 24 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | Pancreatic, Leukemia Mononuclear | X | 7 | Renal, Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M | 38 | Leukemia Mononuclear | X | 15 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M M + + + + | 42 | Leukemia Mononuclear | X | 14 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 50 | Leukemia Mononuclear | X X | 20 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 46 | Leukemia Mononuclear | X X | 19 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Leukemia Mononuclear | X X X | 27 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + | 41 | Leukemia Mononuclear | X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M M M | 30 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Keratoacanthoma | X | 7 | Squamous Cell Papilloma | | 1 | Trichoepithelioma | | 1 | Subcutaneous Tissue, Fibroma | X | 3 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Leukemia Mononuclear | | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X X X | 25 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | Serosa, Mesothelioma Benign | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Leukemia Mononuclear | X | 13 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Leukemia Mononuclear | X X X | 25 | Mesothelioma Malignant | | 1 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X | 27 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 96 NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Mesothelioma Benign | | 2 | Mesothelioma Malignant | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 97 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------