TDMS Study 88034-03 Pathology Tables
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|
| 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|
| 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + M + + M + + + + M + +|
Adenoma | X X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Arrhenoblastoma Malignant | X |
Granulosa Cell Tumor Benign | |
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X |
Polyp Stromal, Multiple | |
Sarcoma Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Histiocytic Sarcoma | X|
Lumbar, Leukemia Mononuclear | X |
Pancreatic, Histiocytic Sarcoma | X|
Pancreatic, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + M + + + + + M M + + M + + M + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + M + + + + + M + + M + M + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|
| 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + M + M + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|
| 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | X|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|
| 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + I I + I + I + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|
| 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + M + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Arrhenoblastoma Malignant | |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X |
Polyp Stromal, Multiple | X X |
Sarcoma Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | |
Iliac, Histiocytic Sarcoma | |
Lumbar, Leukemia Mononuclear | |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + M M + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|
| 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|
| 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 6| 6| 4| | |
DAY ON TEST | 3| 3| 6| 0| 0| 4| | |
| 5| 3| 2| 2| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 17 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 50 |
Carcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 50 |
Leukemia Mononuclear | | 7 |
Pheochromocytoma Benign | | 5 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 50 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 6| 6| 4| | |
DAY ON TEST | 3| 3| 6| 0| 0| 4| | |
| 5| 3| 2| 2| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 7 |
Pars Distalis, Adenoma | X X | 34 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 4 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + | 43 |
Adenoma | | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + | 50 |
Arrhenoblastoma Malignant | | 1 |
Granulosa Cell Tumor Benign | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + | 50 |
Polyp Stromal | | 8 |
Polyp Stromal, Multiple | | 2 |
Sarcoma Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Histiocytic Sarcoma | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Pancreatic, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 43 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 48 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 6| 6| 4| | |
DAY ON TEST | 3| 3| 6| 0| 0| 4| | |
| 5| 3| 2| 2| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 49 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + | 39 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 17 |
__________________________________________________________________________|____________|
Thymus | + + + + | 45 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 50 |
Adenoma | | 1 |
Carcinoma | X | 4 |
Fibroadenoma | X | 18 |
Fibroadenoma, Multiple | X | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + | 50 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 6| 6| 4| | |
DAY ON TEST | 3| 3| 6| 0| 0| 4| | |
| 5| 3| 2| 2| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________|____________|
Nose | + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 50 |
Leukemia Mononuclear | X | 13 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|
| 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|
| 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Granulosa-Theca Tumor Malignant | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X X|
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + |
Carcinoma, Metastatic, Thyroid Gland | |
Deep Cervical, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + M M M + M M + + + + + + + + +|
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + M + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|
| 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + M + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Fibroadenoma | X X X X X|
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Melanoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Carcinoma, Metastatic, Adrenal Cortex| |
Leukemia Mononuclear | X X X X X X X X|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|
| 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + I + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|
| 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|
| 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
Leukemia Mononuclear | X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Granulosa-Theca Tumor Malignant | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Polyp Stromal | X X X X X X |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Deep Cervical, Leukemia Mononuclear | X X|
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + M + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|
| 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + M + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + M + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | |
Carcinoma | |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Melanoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Carcinoma, Metastatic, Adrenal Cortex| |
Leukemia Mononuclear | X X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|
| 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| | |
DAY ON TEST | 3| 0| 6| 8| 3| 3| | |
| 3| 2| 7| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 50 |
Adenoma | | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| | |
DAY ON TEST | 3| 0| 6| 8| 3| 3| | |
| 3| 2| 7| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Leukemia Mononuclear | X | 8 |
Pars Distalis, Adenoma | X X X | 36 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
C-Cell, Adenoma | X X | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 50 |
Adenoma | X | 3 |
Carcinoma | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Granulosa Cell Tumor Malignant | | 1 |
Granulosa-Theca Tumor Malignant | | 1 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | X | 11 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| | |
DAY ON TEST | 3| 0| 6| 8| 3| 3| | |
| 3| 2| 7| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Deep Cervical, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | X | 5 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + | 39 |
Leukemia Mononuclear | | 8 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 47 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Leukemia Mononuclear | X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 46 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X | 11 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Thymus | + M + M + | 43 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 49 |
Adenoma | | 1 |
Carcinoma | X | 1 |
Fibroadenoma | X | 12 |
Fibroadenoma, Multiple | | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Lipoma | X | 1 |
Subcutaneous Tissue, Melanoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 7| | |
DAY ON TEST | 3| 0| 6| 8| 3| 3| | |
| 3| 2| 7| 3| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 50 |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Carcinoma, Metastatic, Adrenal Cortex| X | 1 |
Leukemia Mononuclear | X X | 17 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Leukemia Mononuclear | X X | 10 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|
| 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + I + + + + + + + + + I + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|
| 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + I + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Histiocytic Sarcoma | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X X X |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + M + M + + + + + + + + M + + + M|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + M M + M +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|
| 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M M + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X X X|
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Glands, Adenoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|
| 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|
| 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + I + I + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Benign | X|
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|
| 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +|
Adenoma | X X X X|
Carcinoma | X |
Histiocytic Sarcoma | |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + M + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | |
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + M + + M M + + + + + + + + + M|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + M +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M M + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|
| 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Glands, Adenoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|
| 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 2| 3| 6| 3| 3| | |
| 8| 3| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 16 |
__________________________________________________________________________|____________|
Mesentery | + | 11 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 50 |
Adenoma | | 2 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 50 |
Leukemia Mononuclear | | 10 |
Pheochromocytoma Benign | X X | 5 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 2| 3| 6| 3| 3| | |
| 8| 3| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
Pars Distalis, Adenoma | X X X X X X | 38 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + | 47 |
Adenoma | X X | 7 |
Carcinoma | | 3 |
Histiocytic Sarcoma | | 1 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 49 |
Granulosa Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | | 8 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | X X | 7 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M M + | 36 |
Leukemia Mononuclear | | 8 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 2| 3| 6| 3| 3| | |
| 8| 3| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 49 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + + | 41 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 11 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Leukemia Mononuclear | | 16 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + | 46 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
Adenoma | | 1 |
Carcinoma | | 3 |
Fibroadenoma | X X X | 22 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 2| 3| 6| 3| 3| | |
| 8| 3| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
Glands, Adenoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 49 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 16 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|
| 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Ganglioneuroma | X |
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|
| 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + I + + + + + + + + + + + + + + M +|
Adenoma | X X X X X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | |
Polyp Stromal | X |
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node | + |
Iliac, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|
DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|
| 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Rhabdomyosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Glioma Benign | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | X |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|
DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|
| 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Ganglioneuroma | |
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|
DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|
| 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + M + + + M + + + + M + M +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Thymoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X X |
Fibroadenoma, Multiple | X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|
DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|
| 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Glioma Benign | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 1| 3| 8| 3| 3| | |
| 3| 9| 4| 1| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 50 |
Ganglioneuroma | | 1 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 1| 3| 8| 3| 3| | |
| 3| 9| 4| 1| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + | 49 |
Leukemia Mononuclear | | 7 |
Pars Distalis, Adenoma | X X X X | 33 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 47 |
Adenoma | X | 8 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 50 |
Deciduoma Benign | X | 1 |
Polyp Stromal | X X | 6 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Iliac, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 43 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + | 46 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + | 47 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 49 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Thymus | + + M + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 1| 3| 8| 3| 3| | |
| 3| 9| 4| 1| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 5 |
Thymoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
Carcinoma | | 1 |
Fibroadenoma | X | 8 |
Fibroadenoma, Multiple | | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Basal Cell Adenoma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Rhabdomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Glioma Benign | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| | |
DAY ON TEST | 3| 1| 3| 8| 3| 3| | |
| 3| 9| 4| 1| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|
DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|
| 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|
DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|
| 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Lumbar, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|
DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|
| 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M M + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + M M|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + M + M + + +|
Leukemia Mononuclear | X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | M M + + + + + + + M M + + + + + + M + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M M M + + + + + + M + M + + M + +|
Fibroadenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Keratoacanthoma, Multiple | X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Chondrosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Glioma Malignant | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|
DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|
| 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lipoma | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|
| 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|
| 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X |
Interstitial Cell, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|
| 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + M M + + + + M + M M + M M +|
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Keratoacanthoma, Multiple | |
Leukemia Mononuclear | X X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Chondrosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Glioma Malignant | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|
| 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Lipoma | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 5| | |
DAY ON TEST | 9| 7| 0| 3| 4| 8| | |
| 5| 6| 1| 7| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 50 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X | 26 |
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 4 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 7 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 5| | |
DAY ON TEST | 9| 7| 0| 3| 4| 8| | |
| 5| 6| 1| 7| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 17 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 15 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X | 9 |
Bilateral, Pheochromocytoma Benign | | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Adenoma | | 4 |
Carcinoma | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 13 |
Pars Distalis, Adenoma | X X X X | 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + | 49 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 49 |
Adenoma | X | 3 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 50 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 5| | |
DAY ON TEST | 9| 7| 0| 3| 4| 8| | |
| 5| 6| 1| 7| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Adenoma | X X X | 18 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 19 |
__________________________________________________________________________|____________|
Lymph Node | + + | 18 |
Deep Cervical, Leukemia Mononuclear | X | 2 |
Iliac, Leukemia Mononuclear | X | 3 |
Lumbar, Leukemia Mononuclear | X | 1 |
Pancreatic, Leukemia Mononuclear | X | 4 |
Renal, Leukemia Mononuclear | X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + | 43 |
Leukemia Mononuclear | X X X | 14 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 46 |
Leukemia Mononuclear | X X X | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 49 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 46 |
Leukemia Mononuclear | X X X | 17 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Fibroma | | 1 |
Leukemia Mononuclear | X X X | 27 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 44 |
Leukemia Mononuclear | X X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + M | 33 |
Fibroadenoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Keratoacanthoma | | 2 |
Keratoacanthoma, Multiple | | 1 |
Leukemia Mononuclear | | 2 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 5| | |
DAY ON TEST | 9| 7| 0| 3| 4| 8| | |
| 5| 6| 1| 7| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Chondrosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Glioma Malignant | | 1 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 23 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 23 |
Lipoma | | 1 |
Renal Tubule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 5| | |
DAY ON TEST | 9| 7| 0| 3| 4| 8| | |
| 5| 6| 1| 7| 7| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X | 27 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|
DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|
| 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oral Mucosa | + |
Pharyngeal, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X X X X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|
DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|
| 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X X X|
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Tunica Vaginalis, Mesothelioma Benign| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + M + + + + + + M M + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|
DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|
| 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M M M + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + M + M + + + M + M M + M + M + M M +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|
DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|
| 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Renal Tubule, Adenoma | X |
Renal Tubule, Adenoma, Multiple | X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Carcinoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma Benign | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|
DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|
| 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|
DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|
| 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Tunica Vaginalis, Mesothelioma Benign| X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Bilateral, Interstitial Cell, Adenoma| X X X X X |
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + M + + + M + + + + + + + + + M |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + M + + + + + + + + M |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|
DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|
| 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + M + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + M + M + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M M + M + + + + M M + + M M + + + + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Basal Cell Adenoma | |
Keratoacanthoma | X |
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangioma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|
DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|
| 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Renal Tubule, Adenoma | X |
Renal Tubule, Adenoma, Multiple | |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Transitional Epithelium, Carcinoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 6| | |
DAY ON TEST | 8| 7| 9| 0| 3| 0| | |
| 0| 8| 8| 5| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X X X | 30 |
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Pharyngeal, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 4 |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Leukemia Mononuclear | X | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 50 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 50 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 6| | |
DAY ON TEST | 8| 7| 9| 0| 3| 0| | |
| 0| 8| 8| 5| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 8 |
Bilateral, Pheochromocytoma Benign | X | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Adenoma | | 2 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Leukemia Mononuclear | X X | 15 |
Pars Distalis, Adenoma | X X | 43 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X X | 8 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
Tunica Vaginalis, Mesothelioma Benign| | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 50 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Bilateral, Interstitial Cell, Adenoma| X X | 14 |
Interstitial Cell, Adenoma | | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 6| | |
DAY ON TEST | 8| 7| 9| 0| 3| 0| | |
| 0| 8| 8| 5| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Leukemia Mononuclear | X X | 24 |
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Pancreatic, Leukemia Mononuclear | X X | 5 |
Renal, Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M | 38 |
Leukemia Mononuclear | X | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 46 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 49 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 47 |
Leukemia Mononuclear | X X | 21 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Leukemia Mononuclear | X X X X | 31 |
__________________________________________________________________________|____________|
Thymus | + + + + M | 43 |
Leukemia Mononuclear | X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M | 29 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | | 2 |
Leukemia Mononuclear | X | 2 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X | 4 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 7| 6| | |
DAY ON TEST | 8| 7| 9| 0| 3| 0| | |
| 0| 8| 8| 5| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
0.12 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X | 25 |
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Leukemia Mononuclear | X X | 23 |
Renal Tubule, Adenoma | | 2 |
Renal Tubule, Adenoma, Multiple | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
Transitional Epithelium, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Leukemia Mononuclear | X X X X | 31 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|
| 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Fat, Lipoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|
| 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Histiocytic Sarcoma | |
Renal, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|
| 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + + + + M + + M M|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Thymoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M M M M M M + + M + + M M M + + +|
Carcinoma | |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|
| 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Renal Tubule, Adenoma | X |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|
DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|
| 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X |
Fat, Lipoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|
DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|
| 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X X X X |
Renal, Histiocytic Sarcoma | X |
Renal, Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|
DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|
| 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X X |
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + M M M M + + + + + M M + M M|
Carcinoma | X |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | X |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|
DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|
| 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Renal Tubule, Adenoma | X |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 4| 6| | |
DAY ON TEST | 7| 9| 3| 4| 3| 0| | |
| 1| 7| 4| 9| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
Leiomyoma | | 1 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Hepatocellular Adenoma | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 31 |
__________________________________________________________________________|____________|
Mesentery | + + | 12 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | | 2 |
Fat, Lipoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 4| 6| | |
DAY ON TEST | 7| 9| 3| 4| 3| 0| | |
| 1| 7| 4| 9| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 23 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 50 |
Leukemia Mononuclear | X X | 20 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X | 16 |
Bilateral, Pheochromocytoma Benign | X | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Adenoma | X | 5 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Leukemia Mononuclear | X X | 15 |
Pars Distalis, Adenoma | X X X X | 42 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 50 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Adenoma | | 2 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X | 16 |
Interstitial Cell, Adenoma | X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 4| 6| | |
DAY ON TEST | 7| 9| 3| 4| 3| 0| | |
| 1| 7| 4| 9| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
Leukemia Mononuclear | X X | 26 |
__________________________________________________________________________|____________|
Lymph Node | + | 24 |
Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | X | 4 |
Pancreatic, Leukemia Mononuclear | | 7 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + | 44 |
Leukemia Mononuclear | X X | 21 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 46 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
Leukemia Mononuclear | X X | 25 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 48 |
Leukemia Mononuclear | X X | 23 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Leukemia Mononuclear | X X | 31 |
__________________________________________________________________________|____________|
Thymus | M + + + + | 45 |
Leukemia Mononuclear | X | 8 |
Thymoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M | 28 |
Carcinoma | | 1 |
Fibroadenoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Keratoacanthoma | | 2 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 4| 6| | |
DAY ON TEST | 7| 9| 3| 4| 3| 0| | |
| 1| 7| 4| 9| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 29 |
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Leukemia Mononuclear | X X | 25 |
Renal Tubule, Adenoma | | 2 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 31 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|
DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|
| 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + + +|
Mesothelioma Malignant | X X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X X|
__________________________________________________________________________|
Tooth | + |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|
DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|
| 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Adenoma, Multiple | |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X|
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Tunica Vaginalis, Mesothelioma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
Mesothelioma Malignant | X X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Benign | X |
Mesothelioma Malignant | X X|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|
DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|
| 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + M + + M + + + M + + + + + M + + M M +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | X X|
__________________________________________________________________________|
Thymus | M + + + + + + M + M + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + M M M + M + + + + M + + + M M +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X X |
Squamous Cell Papilloma | |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|
DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|
| 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
Serosa, Mesothelioma Benign | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Mesothelioma Malignant | X|
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Benign | X X |
Mesothelioma Malignant | X X|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|
DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|
| 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Tooth | + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|
DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|
| 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Adenoma, Multiple | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Tunica Vaginalis, Mesothelioma | |
Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Mesothelioma Benign | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + |
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Mesothelioma Benign | |
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|
DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|
| 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Pancreatic, Leukemia Mononuclear | X X X X X |
Renal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + M + + M + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | M + M M + + M + + + + + + + M + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + M + M + + M M + + + M M |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | X X X X |
Squamous Cell Papilloma | X |
Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|
DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|
| 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
Serosa, Mesothelioma Benign | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Mesothelioma Benign | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| | |
DAY ON TEST | 2| 3| 4| 9| 5| 6| | |
| 3| 3| 4| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 48 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 27 |
__________________________________________________________________________|____________|
Mesentery | | 8 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Odontoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| | |
DAY ON TEST | 2| 3| 4| 9| 5| 6| | |
| 3| 3| 4| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 50 |
Leukemia Mononuclear | X X | 18 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 50 |
Leukemia Mononuclear | X | 9 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | X X | 7 |
Bilateral, Pheochromocytoma Benign | X | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Adenoma | | 5 |
Adenoma, Multiple | | 1 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 49 |
Leukemia Mononuclear | X | 15 |
Pars Distalis, Adenoma | X X X X | 40 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
Tunica Vaginalis, Mesothelioma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 49 |
Adenoma | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| | |
DAY ON TEST | 2| 3| 4| 9| 5| 6| | |
| 3| 3| 4| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X | 22 |
Interstitial Cell, Adenoma | X | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 24 |
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Pancreatic, Leukemia Mononuclear | X | 7 |
Renal, Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M | 38 |
Leukemia Mononuclear | X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + | 42 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
Leukemia Mononuclear | X X | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 46 |
Leukemia Mononuclear | X X | 19 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 27 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 41 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M M | 30 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Keratoacanthoma | X | 7 |
Squamous Cell Papilloma | | 1 |
Trichoepithelioma | | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| | |
DAY ON TEST | 2| 3| 4| 9| 5| 6| | |
| 3| 3| 4| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 25 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | | 1 |
Serosa, Mesothelioma Benign | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
Leukemia Mononuclear | X | 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 25 |
Mesothelioma Malignant | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X | 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 88034-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC OZONE Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:21:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| | |
DAY ON TEST | 2| 3| 4| 9| 5| 6| | |
| 3| 3| 4| 0| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma Benign | | 2 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
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---------- END OF REPORT ----------
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