TDMS Study 88034-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
OZONE
NTP Experiment-Test: 88034-03 Report: PEIRPT05
Study Type: CHRONIC Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 02/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 56 56 56 56
Scheduled Sacrifice 6 6 6 6
Early Deaths
Moribund Sacrifice 19 22 17 16
Natural Death 3 4 3 7
Survivors
Terminal Sacrifice 28 24 30 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (49)
Intestine Large, Rectum (43) (48) (45) (48)
Intestine Large, Cecum (50) (50) (50) (50)
Intestine Small, Jejunum (49) (49) (48) (47)
Intestine Small, Ileum (50) (49) (48) (47)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Mesentery (4) (5) (11) (4)
Sarcoma 1 (9%)
Oral Mucosa (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50) (49)
Salivary Glands (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Tongue (1) (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Ganglioneuroma 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 5 (10%) 5 (10%) 5 (10%) 4 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (50) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Pituitary Gland (50) (49) (50) (49)
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 34 (68%) 36 (73%) 38 (76%) 33 (67%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 4 (8%) 5 (10%) 5 (10%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (50) (47) (47)
Adenoma 5 (12%) 3 (6%) 7 (15%) 8 (17%)
Carcinoma 3 (6%) 3 (6%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (50) (49) (49)
Arrhenoblastoma Malignant 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Histiocytic Sarcoma 1 (2%)
Uterus (50) (50) (49) (50)
Deciduoma Benign 1 (2%)
Polyp Stromal 8 (16%) 11 (22%) 7 (14%) 6 (12%)
Polyp Stromal, Multiple 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Sarcoma Stromal, Multiple 1 (2%)
Page 3
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node (5) (9) (3) (3)
Carcinoma, Metastatic, Thyroid Gland 1 (11%)
Iliac, Histiocytic Sarcoma 1 (20%)
Pancreatic, Histiocytic Sarcoma 1 (20%)
Lymph Node, Bronchial (43) (39) (36) (43)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (3%)
Lymph Node, Mandibular (48) (47) (46) (46)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (49) (50) (49) (50)
Hemangiosarcoma 1 (2%)
Lymph Node, Mediastinal (39) (46) (41) (47)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (3%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Spleen (50) (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
Thymus (45) (43) (46) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Carcinoma 4 (8%) 1 (2%) 3 (6%) 1 (2%)
Fibroadenoma 18 (36%) 12 (24%) 22 (44%) 8 (16%)
Fibroadenoma, Multiple 2 (4%) 5 (10%) 1 (2%) 4 (8%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (3)
Rhabdomyosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Glioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50) (50)
Glands, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (50) (49) (49) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Leukemia Mononuclear 17 (34%) 18 (36%) 16 (32%) 17 (34%)
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 48 48 46
Total Primary Neoplasms 116 118 125 97
Total Animals with Benign Neoplasms 41 43 45 41
Total Benign Neoplasms 86 87 96 72
Total Animals with Malignant Neoplasms 26 28 26 23
Total Malignant Neoplasms 30 31 29 25
Total Animals with Metastatic Neoplasms 3 1
Total Metastatic Neoplasm 10 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 56 56 56 56
Scheduled Sacrifice 6 6 6 6
Early Deaths
Moribund Sacrifice 35 40 36 36
Natural Death 6 5 7 7
Accidently Killed 1
Survivors
Terminal Sacrifice 8 5 7 7
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Intestine Large, Rectum (50) (50) (50) (49)
Intestine Large, Cecum (50) (50) (49) (50)
Intestine Small, Duodenum (50) (50) (50) (49)
Intestine Small, Jejunum (50) (50) (48) (49)
Intestine Small, Ileum (50) (50) (49) (48)
Leiomyoma 1 (2%)
Liver (50) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 2 (4%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (12) (6) (12) (8)
Histiocytic Sarcoma 1 (8%)
Fat, Lipoma 1 (8%)
Oral Mucosa (1) (1)
Pharyngeal, Squamous Cell Papilloma 1 (100%) 1 (100%)
Pancreas (50) (50) (50) (50)
Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (49) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Tooth (2) (2) (1) (2)
Odontoma 1 (50%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 9 (18%) 8 (16%) 16 (32%) 7 (14%)
Bilateral, Pheochromocytoma Benign 8 (16%) 9 (18%) 8 (16%) 9 (18%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 4 (8%) 2 (4%) 5 (10%) 5 (10%)
Adenoma, Multiple 1 (2%)
Carcinoma 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Parathyroid Gland (49) (49) (48) (47)
Pituitary Gland (50) (50) (49) (49)
Pars Distalis, Adenoma 41 (82%) 43 (86%) 42 (86%) 40 (82%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Adenoma 1 (2%) 8 (16%) 2 (4%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (49) (50) (50) (49)
Adenoma 3 (6%) 2 (4%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (49) (50) (50) (50)
Adenoma 2 (4%)
Seminal Vesicle (50) (50) (50) (50)
Adenoma 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 9 (18%) 14 (28%) 16 (32%) 22 (44%)
Page 9
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Interstitial Cell, Adenoma 18 (36%) 9 (18%) 15 (30%) 10 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (18) (10) (24) (10)
Renal, Histiocytic Sarcoma 1 (4%)
Lymph Node, Bronchial (43) (38) (44) (38)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Lymph Node, Mandibular (46) (46) (46) (42)
Lymph Node, Mesenteric (49) (49) (50) (50)
Lymph Node, Mediastinal (46) (47) (48) (46)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Spleen (50) (50) (50) (50)
Fibroma 1 (2%)
Thymus (44) (43) (45) (41)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (33) (29) (28) (30)
Carcinoma 1 (4%)
Fibroadenoma 2 (6%) 1 (3%) 2 (7%) 1 (3%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%) 2 (4%) 7 (14%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 4 (8%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Chondrosarcoma 1 (2%)
Skeletal Muscle (2) (2) (1)
Squamous Cell Carcinoma, Metastatic, Lung 1 (50%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (50) (50) (50) (50)
Trachea (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Lipoma 1 (2%)
Renal Tubule, Adenoma 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Transitional Epithelium, Carcinoma 1 (2%)
Page 11
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 27 (54%) 31 (62%) 31 (62%) 27 (54%)
Mesothelioma Benign 1 (2%) 2 (4%)
Mesothelioma Malignant 2 (4%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 49 49 49
Total Primary Neoplasms 152 159 166 159
Total Animals with Benign Neoplasms 48 47 48 49
Total Benign Neoplasms 111 112 123 119
Total Animals with Malignant Neoplasms 33 35 32 33
Total Malignant Neoplasms 41 47 43 40
Total Animals with Metastatic Neoplasms 2 1 1 1
Total Metastatic Neoplasm 5 1 2 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------