TDMS Study 88034-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) OZONE NTP Experiment-Test: 88034-03 Report: PEIRPT05 Study Type: CHRONIC Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 56 56 56 56 Scheduled Sacrifice 6 6 6 6 Early Deaths Moribund Sacrifice 19 22 17 16 Natural Death 3 4 3 7 Survivors Terminal Sacrifice 28 24 30 27 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (49) Intestine Large, Rectum (43) (48) (45) (48) Intestine Large, Cecum (50) (50) (50) (50) Intestine Small, Jejunum (49) (49) (48) (47) Intestine Small, Ileum (50) (49) (48) (47) Liver (50) (50) (50) (50) Hepatocellular Adenoma 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%) Mesentery (4) (5) (11) (4) Sarcoma 1 (9%) Oral Mucosa (1) (1) Pharyngeal, Squamous Cell Papilloma 1 (100%) Pancreas (50) (50) (50) (49) Salivary Glands (50) (50) (50) (50) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Squamous Cell Carcinoma 1 (2%) Stomach, Glandular (50) (50) (50) (50) Tongue (1) (1) (1) Squamous Cell Papilloma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adenoma 1 (2%) 2 (4%) 1 (2%) Carcinoma 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) Adrenal Medulla (50) (50) (50) (50) Ganglioneuroma 1 (2%) Pheochromocytoma Complex 1 (2%) Pheochromocytoma Benign 5 (10%) 5 (10%) 5 (10%) 4 (8%) Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) Islets, Pancreatic (50) (50) (50) (49) Adenoma 1 (2%) Carcinoma 1 (2%) 1 (2%) Pituitary Gland (50) (49) (50) (49) Histiocytic Sarcoma 1 (2%) Pars Distalis, Adenoma 34 (68%) 36 (73%) 38 (76%) 33 (67%) Thyroid Gland (50) (50) (50) (50) Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%) C-Cell, Adenoma 4 (8%) 5 (10%) 5 (10%) 1 (2%) C-Cell, Carcinoma 1 (2%) 2 (4%) Follicular Cell, Adenoma 1 (2%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (43) (50) (47) (47) Adenoma 5 (12%) 3 (6%) 7 (15%) 8 (17%) Carcinoma 3 (6%) 3 (6%) 1 (2%) Histiocytic Sarcoma 1 (2%) Bilateral, Adenoma 1 (2%) Ovary (50) (50) (49) (49) Arrhenoblastoma Malignant 1 (2%) Granulosa Cell Tumor Malignant 1 (2%) 1 (2%) Granulosa Cell Tumor Benign 1 (2%) Granulosa-Theca Tumor Malignant 1 (2%) Histiocytic Sarcoma 1 (2%) Uterus (50) (50) (49) (50) Deciduoma Benign 1 (2%) Polyp Stromal 8 (16%) 11 (22%) 7 (14%) 6 (12%) Polyp Stromal, Multiple 2 (4%) 1 (2%) 1 (2%) 1 (2%) Sarcoma Stromal, Multiple 1 (2%) Page 3 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) 1 (2%) Lymph Node (5) (9) (3) (3) Carcinoma, Metastatic, Thyroid Gland 1 (11%) Iliac, Histiocytic Sarcoma 1 (20%) Pancreatic, Histiocytic Sarcoma 1 (20%) Lymph Node, Bronchial (43) (39) (36) (43) Histiocytic Sarcoma 1 (2%) Osteosarcoma, Metastatic, Bone 1 (3%) Lymph Node, Mandibular (48) (47) (46) (46) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (2%) Lymph Node, Mesenteric (49) (50) (49) (50) Hemangiosarcoma 1 (2%) Lymph Node, Mediastinal (39) (46) (41) (47) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (3%) 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Spleen (50) (50) (50) (49) Histiocytic Sarcoma 1 (2%) Thymus (45) (43) (46) (49) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (2%) Thymoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (49) (50) (50) Adenoma 1 (2%) 1 (2%) 1 (2%) Carcinoma 4 (8%) 1 (2%) 3 (6%) 1 (2%) Fibroadenoma 18 (36%) 12 (24%) 22 (44%) 8 (16%) Fibroadenoma, Multiple 2 (4%) 5 (10%) 1 (2%) 4 (8%) Skin (50) (50) (50) (50) Basal Cell Adenoma 1 (2%) Keratoacanthoma 1 (2%) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) Subcutaneous Tissue, Melanoma Malignant 1 (2%) Subcutaneous Tissue, Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosarcoma 1 (2%) Skeletal Muscle (1) (3) Rhabdomyosarcoma 1 (33%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Glioma Benign 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) (50) Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 2 (4%) Carcinoma, Metastatic, Mammary Gland 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Carcinoma, Metastatic, Adrenal Cortex 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Nose (50) (50) (50) (50) Glands, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Renal Tubule, Adenoma 1 (2%) 1 (2%) Urinary Bladder (50) (49) (49) (50) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%) Leukemia Mononuclear 17 (34%) 18 (36%) 16 (32%) 17 (34%) * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont Multiple Organs *(50) *(50) *(50) *(50) Mesothelioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 48 48 48 46 Total Primary Neoplasms 116 118 125 97 Total Animals with Benign Neoplasms 41 43 45 41 Total Benign Neoplasms 86 87 96 72 Total Animals with Malignant Neoplasms 26 28 26 23 Total Malignant Neoplasms 30 31 29 25 Total Animals with Metastatic Neoplasms 3 1 Total Metastatic Neoplasm 10 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 56 56 56 56 Scheduled Sacrifice 6 6 6 6 Early Deaths Moribund Sacrifice 35 40 36 36 Natural Death 6 5 7 7 Accidently Killed 1 Survivors Terminal Sacrifice 8 5 7 7 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (50) Intestine Large, Rectum (50) (50) (50) (49) Intestine Large, Cecum (50) (50) (49) (50) Intestine Small, Duodenum (50) (50) (50) (49) Intestine Small, Jejunum (50) (50) (48) (49) Intestine Small, Ileum (50) (50) (49) (48) Leiomyoma 1 (2%) Liver (50) (50) (50) (50) Hepatocellular Carcinoma 1 (2%) Hepatocellular Adenoma 2 (4%) 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) Mesentery (12) (6) (12) (8) Histiocytic Sarcoma 1 (8%) Fat, Lipoma 1 (8%) Oral Mucosa (1) (1) Pharyngeal, Squamous Cell Papilloma 1 (100%) 1 (100%) Pancreas (50) (50) (50) (50) Adenoma 1 (2%) Histiocytic Sarcoma 1 (2%) Salivary Glands (49) (50) (50) (50) Stomach, Forestomach (50) (50) (50) (50) Squamous Cell Papilloma 1 (2%) Stomach, Glandular (50) (50) (50) (50) Tooth (2) (2) (1) (2) Odontoma 1 (50%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Histiocytic Sarcoma 1 (2%) Squamous Cell Carcinoma, Metastatic, Lung 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Adenoma 1 (2%) 1 (2%) Adrenal Medulla (50) (50) (50) (50) Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%) 1 (2%) Pheochromocytoma Complex 1 (2%) Pheochromocytoma Benign 9 (18%) 8 (16%) 16 (32%) 7 (14%) Bilateral, Pheochromocytoma Benign 8 (16%) 9 (18%) 8 (16%) 9 (18%) Islets, Pancreatic (50) (50) (50) (50) Adenoma 4 (8%) 2 (4%) 5 (10%) 5 (10%) Adenoma, Multiple 1 (2%) Carcinoma 3 (6%) 3 (6%) 2 (4%) 2 (4%) Parathyroid Gland (49) (49) (48) (47) Pituitary Gland (50) (50) (49) (49) Pars Distalis, Adenoma 41 (82%) 43 (86%) 42 (86%) 40 (82%) Pars Distalis, Carcinoma 1 (2%) Thyroid Gland (49) (50) (50) (50) C-Cell, Adenoma 1 (2%) 8 (16%) 2 (4%) 1 (2%) C-Cell, Carcinoma 1 (2%) 3 (6%) 2 (4%) 1 (2%) Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%) Follicular Cell, Carcinoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (1) (1) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Preputial Gland (49) (50) (50) (49) Adenoma 3 (6%) 2 (4%) 2 (4%) Carcinoma 1 (2%) 1 (2%) 1 (2%) Prostate (49) (50) (50) (50) Adenoma 2 (4%) Seminal Vesicle (50) (50) (50) (50) Adenoma 1 (2%) Testes (50) (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 9 (18%) 14 (28%) 16 (32%) 22 (44%) Page 9 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Interstitial Cell, Adenoma 18 (36%) 9 (18%) 15 (30%) 10 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Lymph Node (18) (10) (24) (10) Renal, Histiocytic Sarcoma 1 (4%) Lymph Node, Bronchial (43) (38) (44) (38) Squamous Cell Carcinoma, Metastatic, Lung 1 (2%) Lymph Node, Mandibular (46) (46) (46) (42) Lymph Node, Mesenteric (49) (49) (50) (50) Lymph Node, Mediastinal (46) (47) (48) (46) Squamous Cell Carcinoma, Metastatic, Lung 1 (2%) Spleen (50) (50) (50) (50) Fibroma 1 (2%) Thymus (44) (43) (45) (41) Thymoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (33) (29) (28) (30) Carcinoma 1 (4%) Fibroadenoma 2 (6%) 1 (3%) 2 (7%) 1 (3%) Skin (50) (50) (50) (50) Basal Cell Adenoma 1 (2%) Keratoacanthoma 2 (4%) 2 (4%) 2 (4%) 7 (14%) Keratoacanthoma, Multiple 1 (2%) Squamous Cell Carcinoma 1 (2%) 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%) Trichoepithelioma 1 (2%) Subcutaneous Tissue, Fibroma 1 (2%) 4 (8%) 1 (2%) 3 (6%) Subcutaneous Tissue, Fibrosarcoma 2 (4%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%) 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Chondrosarcoma 1 (2%) Skeletal Muscle (2) (2) (1) Squamous Cell Carcinoma, Metastatic, Lung 1 (50%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Carcinoma, Metastatic, Pituitary Gland 1 (2%) Glioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (50) (50) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Lung (50) (50) (50) (50) Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%) 2 (4%) 2 (4%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (2%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (2%) Pheochromocytoma Malignant, Metastatic, Adrenal Medulla 1 (2%) Squamous Cell Carcinoma 1 (2%) Nose (50) (50) (50) (50) Trachea (50) (50) (50) (50) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) (1) (1) Carcinoma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Lipoma 1 (2%) Renal Tubule, Adenoma 2 (4%) 2 (4%) 2 (4%) 1 (2%) Renal Tubule, Adenoma, Multiple 1 (2%) Renal Tubule, Carcinoma 1 (2%) Transitional Epithelium, Carcinoma 1 (2%) Urinary Bladder (50) (50) (50) (50) Transitional Epithelium, Carcinoma 1 (2%) Page 11 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 1 (2%) Leukemia Mononuclear 27 (54%) 31 (62%) 31 (62%) 27 (54%) Mesothelioma Benign 1 (2%) 2 (4%) Mesothelioma Malignant 2 (4%) 1 (2%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 12 NTP Experiment-Test: 88034-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 19:53:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 0.12 PPM 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 49 49 49 Total Primary Neoplasms 152 159 166 159 Total Animals with Benign Neoplasms 48 47 48 49 Total Benign Neoplasms 111 112 123 119 Total Animals with Malignant Neoplasms 33 35 32 33 Total Malignant Neoplasms 41 47 43 40 Total Animals with Metastatic Neoplasms 2 1 1 1 Total Metastatic Neoplasm 5 1 2 1 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------