TDMS Study 88034-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 03 TIME: 20:09:41
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88034
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 03 TIME: 20:09:41
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88034
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 03 TIME: 20:09:41
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88034
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 6 OZONE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Keratoacanthoma
Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
====================================================================================================
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 6.3% 0.0% 14.3% 0.0% | 0.0% 4.2% 5.8% 3.7% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | 0/28 (0%) 1/24 (4%) 1/30 (3%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 681 --- 733 (T) --- | --- 733 (T) 659 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.474N P=0.477N P=0.757N P=0.541N | P=0.378 P=0.469 P=0.253 P=0.493 |
|INCIDENTAL TUMOR | P=0.458N P=0.443N P=0.756N P=0.487N | P=0.381 P=0.469 P=0.268 P=0.493 |
|LOGISTIC REGRESSION | P=0.461N P=0.496N P=0.748N P=0.501N | P=0.369 P=0.469 P=0.242 P=0.493 |
|COCHRAN-ARMITAGE | P=0.456N | P=0.373 |
|FISHER EXACT | P=0.500N P=0.753N P=0.500N | P=0.500 P=0.247 P=0.500 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 17/50 (34%) 24/50 (48%) 16/50 (32%) | 6/50 (12%) 5/50 (10%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 83.0% 80.5% 94.2% 81.6% | 19.7% 16.8% 17.3% 14.8% |
|TERMINAL (d) | 5/8 (63%) 2/5 (40%) 6/7 (86%) 4/7 (57%) | 4/28 (14%) 2/24 (8%) 3/30 (10%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | 606 605 442 526 | 688 568 665 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.506 P=0.498 P=0.191 P=0.549 | P=0.338N P=0.580N P=0.568N P=0.402N |
|INCIDENTAL TUMOR | P=0.477N P=0.541N P=0.087 P=0.456N | P=0.340N P=0.503N P=0.538N P=0.387N |
|LOGISTIC REGRESSION | P=0.527 P=0.530N P=0.093 P=0.514N | P=0.351N P=0.533N P=0.574N P=0.408N |
|COCHRAN-ARMITAGE | P=0.527 | P=0.349N |
|FISHER EXACT | P=0.583N P=0.111 P=0.500N | P=0.500N P=0.620N P=0.370N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 18/50 (36%) 25/50 (50%) 18/50 (36%) | 6/50 (12%) 6/50 (12%) 6/50 (12%) 4/50 (8%) |
|ADJUSTED (b) | 83.0% 81.4% 94.9% 83.9% | 19.7% 18.6% 17.3% 14.8% |
|TERMINAL (d) | 5/8 (63%) 2/5 (40%) 6/7 (86%) 4/7 (57%) | 4/28 (14%) 2/24 (8%) 3/30 (10%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | 606 605 442 526 | 688 470 665 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383 P=0.430 P=0.153 P=0.405 | P=0.285N P=0.541 P=0.568N P=0.402N |
|INCIDENTAL TUMOR | P=0.446 P=0.566 P=0.058 P=0.559 | P=0.294N P=0.605 P=0.538N P=0.387N |
|LOGISTIC REGRESSION | P=0.365 P=0.570 P=0.059 P=0.495 | P=0.301N P=0.609 P=0.574N P=0.408N |
|COCHRAN-ARMITAGE | P=0.380 | P=0.293N |
|FISHER EXACT | P=0.500 P=0.078 P=0.500 | P=0.620N P=0.620N P=0.370N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 0/50 (0%) 2/50 (4%) 2/49 (4%) | 5/43 (12%) 3/50 (6%) 8/47 (17%) 8/47 (17%) |
|ADJUSTED (b) | 24.5% 0.0% 18.4% 4.1% | 21.6% 12.5% 24.9% 30.0% |
|TERMINAL (d) | 1/8 (13%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | 4/21 (19%) 3/24 (13%) 5/27 (19%) 6/24 (25%) |
|FIRST INCIDENCE (DAYS) | 676 --- 671 372 | 709 733 (T) 659 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.509 P=0.140N P=0.475N P=0.532N | P=0.112 P=0.301N P=0.407 P=0.329 |
|INCIDENTAL TUMOR | P=0.480 P=0.112N P=0.474N P=0.585N | P=0.108 P=0.284N P=0.438 P=0.341 |
|LOGISTIC REGRESSION | P=0.533 P=0.113N P=0.462N P=0.514N | P=0.092 P=0.277N P=0.418 P=0.315 |
|COCHRAN-ARMITAGE | P=0.531 | P=0.098 |
|FISHER EXACT | P=0.117N P=0.490N P=0.500N | P=0.276N P=0.336 P=0.336 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/50 (2%) 0/50 (0%) 1/49 (2%) | 0/43 (0%) 3/50 (6%) 3/47 (6%) 1/47 (2%) |
|ADJUSTED (b) | 2.2% 3.6% 0.0% 4.5% | 0.0% 12.5% 11.1% 4.2% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 0/21 (0%) 3/24 (13%) 3/27 (11%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 498 639 --- 653 | --- 733 (T) 733 (T) 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595N P=0.757 P=0.509N P=0.747N | P=0.567N P=0.143 P=0.167 P=0.527 |
|INCIDENTAL TUMOR | P=0.597N P=0.756N P=0.443N P=0.716 | P=0.567N P=0.143 P=0.167 P=0.527 |
|LOGISTIC REGRESSION | P=0.601N P=0.758N P=0.493N P=0.747 | P=0.567N P=0.143 P=0.167 P=0.527 |
|COCHRAN-ARMITAGE | P=0.593N | P=0.597N |
|FISHER EXACT | P=0.747N P=0.495N P=0.753N | P=0.151 P=0.138 P=0.522 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 1/50 (2%) 2/50 (4%) 3/49 (6%) | 5/43 (12%) 5/50 (10%) 11/47 (23%) 9/47 (19%) |
|ADJUSTED (b) | 26.2% 3.6% 18.4% 8.5% | 21.6% 20.8% 35.2% 33.9% |
|TERMINAL (d) | 1/8 (13%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | 4/21 (19%) 5/24 (21%) 8/27 (30%) 7/24 (29%) |
|FIRST INCIDENCE (DAYS) | 498 639 671 372 | 709 733 (T) 659 685 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.536 P=0.205N P=0.322N P=0.518N | P=0.107 P=0.567N P=0.172 P=0.240 |
|INCIDENTAL TUMOR | P=0.513 P=0.173N P=0.294N P=0.605N | P=0.103 P=0.549N P=0.187 P=0.249 |
|LOGISTIC REGRESSION | P=0.556 P=0.170N P=0.320N P=0.523N | P=0.085 P=0.545N P=0.173 P=0.222 |
|COCHRAN-ARMITAGE | P=0.557 | P=0.093 |
|FISHER EXACT | P=0.175N P=0.329N P=0.500N | P=0.530N P=0.118 P=0.246 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 5/50 (10%) 6/50 (12%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 15.1% 6.1% 49.8% 35.0% | 0.0% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 3/7 (43%) 1/7 (14%) | 0/28 (0%) 1/24 (4%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 578 591 625 621 | --- 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.156 P=0.312N P=0.498 P=0.370 | P=0.457N P=0.469 (e) (e) |
|INCIDENTAL TUMOR | P=0.220 P=0.362N P=0.417 P=0.465 | P=0.457N P=0.469 (e) (e) |
|LOGISTIC REGRESSION | P=0.148 P=0.337N P=0.511 P=0.378 | P=0.457N P=0.469 (e) (e) |
|COCHRAN-ARMITAGE | P=0.148 | P=0.467N |
|FISHER EXACT | P=0.339N P=0.500 P=0.370 | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 17.8% 27.7% 21.4% 18.6% | 3.6% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 1/5 (20%) 1/7 (14%) 1/7 (14%) | 1/28 (4%) 1/24 (4%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 565 639 715 658 | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.358N P=0.611 P=0.517N P=0.524N | P=0.203N P=0.728 P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.314N P=0.581 P=0.560N P=0.469N | P=0.203N P=0.728 P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.359N P=0.656N P=0.489N P=0.495N | P=0.203N P=0.728 P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.357N | P=0.214N |
|FISHER EXACT | P=0.661N P=0.500N P=0.500N | P=0.753N P=0.500N P=0.505N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 5/50 (10%) 7/50 (14%) 8/50 (16%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 30.2% 32.2% 65.5% 48.5% | 3.6% 8.3% 0.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 1/5 (20%) 4/7 (57%) 2/7 (29%) | 1/28 (4%) 2/24 (8%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 565 591 625 621 | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.319 P=0.399N P=0.600 P=0.481 | P=0.131N P=0.446 P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.421 P=0.463N P=0.510 P=0.601 | P=0.131N P=0.446 P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.311 P=0.374N P=0.602N P=0.512 | P=0.131N P=0.446 P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.314 | P=0.142N |
|FISHER EXACT | P=0.380N P=0.613N P=0.500 | P=0.500 P=0.500N P=0.505N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 18.0% 38.3% 22.9% 8.3% | 3.6% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 1/5 (20%) 1/7 (14%) 0/7 (0%) | 1/28 (4%) 1/24 (4%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 681 709 722 695 | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.266N P=0.406 P=0.684N P=0.548N | P=0.203N P=0.728 P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.282N P=0.494 P=0.688N P=0.501N | P=0.203N P=0.728 P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.275N P=0.474 P=0.667N P=0.514N | P=0.203N P=0.728 P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.280N | P=0.211N |
|FISHER EXACT | P=0.500 P=0.691N P=0.500N | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 18.0% 38.3% 22.9% 8.3% | 3.6% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 1/5 (20%) 1/7 (14%) 0/7 (0%) | 1/28 (4%) 1/24 (4%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 681 709 722 695 | 733 (T) 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.266N P=0.406 P=0.684N P=0.548N | P=0.203N P=0.728 P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.282N P=0.494 P=0.688N P=0.501N | P=0.203N P=0.728 P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.275N P=0.474 P=0.667N P=0.514N | P=0.203N P=0.728 P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.280N | P=0.211N |
|FISHER EXACT | P=0.500 P=0.691N P=0.500N | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.1% 8.3% 4.2% 0.0% | 0.0% 2.6% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 0/28 (0%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 606 698 654 --- | --- 611 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175N P=0.479N P=0.470N P=0.275N | P=0.454N P=0.500 (e) (e) |
|INCIDENTAL TUMOR | P=0.157N P=0.449N P=0.491N P=0.203N | P=0.511N P=0.602 (e) (e) |
|LOGISTIC REGRESSION | P=0.164N P=0.495N P=0.500N P=0.235N | P=0.443N P=0.512 (e) (e) |
|COCHRAN-ARMITAGE | P=0.166N | P=0.464N |
|FISHER EXACT | P=0.500N P=0.500N P=0.247N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.1% 8.3% 4.2% 3.1% | 0.0% 2.6% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 0/28 (0%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 606 698 654 616 | --- 611 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.447N P=0.479N P=0.470N P=0.531N | P=0.454N P=0.500 (e) (e) |
|INCIDENTAL TUMOR | P=0.396N P=0.449N P=0.491N P=0.430N | P=0.511N P=0.602 (e) (e) |
|LOGISTIC REGRESSION | P=0.425N P=0.495N P=0.500N P=0.498N | P=0.443N P=0.512 (e) (e) |
|COCHRAN-ARMITAGE | P=0.429N | P=0.464N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.1% 8.3% 4.2% 3.1% | 0.0% 2.6% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 0/28 (0%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 606 698 654 616 | --- 611 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.447N P=0.479N P=0.470N P=0.531N | P=0.454N P=0.500 (e) (e) |
|INCIDENTAL TUMOR | P=0.396N P=0.449N P=0.491N P=0.430N | P=0.511N P=0.602 (e) (e) |
|LOGISTIC REGRESSION | P=0.425N P=0.495N P=0.500N P=0.498N | P=0.443N P=0.512 (e) (e) |
|COCHRAN-ARMITAGE | P=0.429N | P=0.464N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 2.2% 16.4% 20.4% 25.4% | 0.0% 0.0% 6.4% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 1/7 (14%) 1/7 (14%) | 0/28 (0%) 0/24 (0%) 1/30 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 514 537 698 619 | --- --- 723 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271 P=0.474 P=0.504 P=0.302 | P=0.550 (e) P=0.258 (e) |
|INCIDENTAL TUMOR | P=0.224 P=0.558 P=0.539 P=0.290 | P=0.547 (e) P=0.268 (e) |
|LOGISTIC REGRESSION | P=0.246 P=0.500 P=0.501 P=0.309 | P=0.545 (e) P=0.255 (e) |
|COCHRAN-ARMITAGE | P=0.244 | P=0.544 |
|FISHER EXACT | P=0.500 P=0.500 P=0.309 | (e) P=0.247 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 3/50 (6%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 14.4% 18.6% 33.7% 30.1% | 0.0% 0.0% 6.4% 0.0% |
|TERMINAL (d) | 1/8 (13%) 0/5 (0%) 2/7 (29%) 1/7 (14%) | 0/28 (0%) 0/24 (0%) 1/30 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 514 537 698 619 | --- --- 723 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.301 P=0.454 P=0.479 P=0.307 | P=0.550 (e) P=0.258 (e) |
|INCIDENTAL TUMOR | P=0.281 P=0.491 P=0.506 P=0.318 | P=0.547 (e) P=0.268 (e) |
|LOGISTIC REGRESSION | P=0.284 P=0.500 P=0.515 P=0.341 | P=0.545 (e) P=0.255 (e) |
|COCHRAN-ARMITAGE | P=0.283 | P=0.544 |
|FISHER EXACT | P=0.500 P=0.500 P=0.339 | (e) P=0.247 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 4/50 (8%) 1/50 (2%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 14.3% 0.0% | 14.3% 4.2% 8.1% 3.7% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | 4/28 (14%) 1/24 (4%) 1/30 (3%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) --- | 733 (T) 733 (T) 536 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658 (e) P=0.473 (e) | P=0.237N P=0.225N P=0.461N P=0.187N |
|INCIDENTAL TUMOR | P=0.658 (e) P=0.473 (e) | P=0.247N P=0.225N P=0.526N P=0.187N |
|LOGISTIC REGRESSION | P=0.658 (e) P=0.473 (e) | P=0.251N P=0.223N P=0.484N P=0.187N |
|COCHRAN-ARMITAGE | P=0.655 | P=0.249N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.181N P=0.500N P=0.181N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 5/50 (10%) 2/50 (4%) 4/50 (8%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 14.3% 0.0% | 17.9% 8.3% 10.4% 3.7% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | 5/28 (18%) 2/24 (8%) 1/30 (3%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) --- | 733 (T) 733 (T) 536 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.658 (e) P=0.473 (e) | P=0.139N P=0.278N P=0.459N P=0.108N |
|INCIDENTAL TUMOR | P=0.658 (e) P=0.473 (e) | P=0.144N P=0.278N P=0.506N P=0.108N |
|LOGISTIC REGRESSION | P=0.658 (e) P=0.473 (e) | P=0.148N P=0.278N P=0.483N P=0.108N |
|COCHRAN-ARMITAGE | P=0.655 | P=0.148N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.218N P=0.500N P=0.102N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) | 20/50 (40%) 17/50 (34%) 23/50 (46%) 12/50 (24%) |
|ADJUSTED (b) | 21.3% 8.3% 28.6% 2.9% | 54.6% 57.1% 59.6% 40.4% |
|TERMINAL (d) | 1/8 (13%) 0/5 (0%) 2/7 (29%) 0/7 (0%) | 12/28 (43%) 12/24 (50%) 15/30 (50%) 10/27 (37%) |
|FIRST INCIDENCE (DAYS) | 715 698 733 (T) 611 | 571 596 536 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453N P=0.569N P=0.682 P=0.501N | P=0.092N P=0.533N P=0.461 P=0.099N |
|INCIDENTAL TUMOR | P=0.453N P=0.487N P=0.682 P=0.477N | P=0.094N P=0.366N P=0.444 P=0.079N |
|LOGISTIC REGRESSION | P=0.484N P=0.520N P=0.686N P=0.505N | P=0.099N P=0.393N P=0.414 P=0.078N |
|COCHRAN-ARMITAGE | P=0.475N | P=0.102N |
|FISHER EXACT | P=0.500N P=0.691N P=0.500N | P=0.339N P=0.343 P=0.066N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) | 21/50 (42%) 18/50 (36%) 24/50 (48%) 12/50 (24%) |
|ADJUSTED (b) | 21.3% 8.3% 28.6% 2.9% | 57.5% 60.6% 60.6% 40.4% |
|TERMINAL (d) | 1/8 (13%) 0/5 (0%) 2/7 (29%) 0/7 (0%) | 13/28 (46%) 13/24 (54%) 15/30 (50%) 10/27 (37%) |
|FIRST INCIDENCE (DAYS) | 715 698 733 (T) 611 | 571 596 536 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453N P=0.569N P=0.682 P=0.501N | P=0.063N P=0.545N P=0.465 P=0.069N |
|INCIDENTAL TUMOR | P=0.453N P=0.487N P=0.682 P=0.477N | P=0.061N P=0.379N P=0.454 P=0.052N |
|LOGISTIC REGRESSION | P=0.484N P=0.520N P=0.686N P=0.505N | P=0.065N P=0.400N P=0.416 P=0.052N |
|COCHRAN-ARMITAGE | P=0.475N | P=0.069N |
|FISHER EXACT | P=0.500N P=0.691N P=0.500N | P=0.341N P=0.344 P=0.044N* |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) | 23/50 (46%) 19/50 (38%) 25/50 (50%) 13/50 (26%) |
|ADJUSTED (b) | 21.3% 8.3% 28.6% 2.9% | 63.1% 64.2% 63.3% 43.9% |
|TERMINAL (d) | 1/8 (13%) 0/5 (0%) 2/7 (29%) 0/7 (0%) | 15/28 (54%) 14/24 (58%) 16/30 (53%) 11/27 (41%) |
|FIRST INCIDENCE (DAYS) | 715 698 733 (T) 611 | 571 596 536 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453N P=0.569N P=0.682 P=0.501N | P=0.046N* P=0.485N P=0.544 P=0.048N* |
|INCIDENTAL TUMOR | P=0.453N P=0.487N P=0.682 P=0.477N | P=0.043N* P=0.317N P=0.545 P=0.035N* |
|LOGISTIC REGRESSION | P=0.484N P=0.520N P=0.686N P=0.505N | P=0.047N* P=0.328N P=0.513 P=0.035N* |
|COCHRAN-ARMITAGE | P=0.475N | P=0.053N |
|FISHER EXACT | P=0.500N P=0.691N P=0.500N | P=0.272N P=0.421 P=0.030N* |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.1% 3.4% 0.0% 0.0% | 3.6% 5.7% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 1/28 (4%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 462 625 --- --- | 733 (T) 664 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.219N P=0.759N P=0.513N P=0.504N | P=0.144N P=0.463 P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.209N P=0.758 P=0.443N P=0.581N | P=0.134N P=0.504 P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.224N P=0.760N P=0.497N P=0.603N | P=0.141N P=0.495 P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.211N | P=0.140N |
|FISHER EXACT | P=0.753N P=0.500N P=0.500N | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.1% 3.4% 0.0% 0.0% | 3.6% 5.7% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 1/28 (4%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 462 625 --- --- | 733 (T) 664 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.219N P=0.759N P=0.513N P=0.504N | P=0.144N P=0.463 P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.209N P=0.758 P=0.443N P=0.581N | P=0.134N P=0.504 P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.224N P=0.760N P=0.497N P=0.603N | P=0.141N P=0.495 P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.211N | P=0.140N |
|FISHER EXACT | P=0.753N P=0.500N P=0.500N | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 41/50 (82%) 43/50 (86%) 42/49 (86%) 40/49 (82%) | 34/50 (68%) 36/49 (73%) 38/50 (76%) 33/49 (67%) |
|ADJUSTED (b) | 94.3% 100.0% 100.0% 95.1% | 86.7% 94.5% 88.3% 88.8% |
|TERMINAL (d) | 6/8 (75%) 5/5 (100%) 7/7 (100%) 5/7 (71%) | 23/28 (82%) 22/24 (92%) 25/30 (83%) 22/26 (85%) |
|FIRST INCIDENCE (DAYS) | 462 441 387 422 | 502 469 536 571 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.464N P=0.412 P=0.544N P=0.531 | P=0.423N P=0.168 P=0.463 P=0.485 |
|INCIDENTAL TUMOR | P=0.254N P=0.511 P=0.510 P=0.335N | P=0.519N P=0.248 P=0.378 P=0.522 |
|LOGISTIC REGRESSION | P=0.378N P=0.392 P=0.363 P=0.487N | P=0.517N P=0.277 P=0.359 P=0.504 |
|COCHRAN-ARMITAGE | P=0.452N | P=0.450N |
|FISHER EXACT | P=0.393 P=0.410 P=0.584N | P=0.353 P=0.252 P=0.558N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 41/50 (82%) 44/50 (88%) 42/49 (86%) 40/49 (82%) | 34/50 (68%) 36/49 (73%) 38/50 (76%) 33/49 (67%) |
|ADJUSTED (b) | 94.3% 100.0% 100.0% 95.1% | 86.7% 94.5% 88.3% 88.8% |
|TERMINAL (d) | 6/8 (75%) 5/5 (100%) 7/7 (100%) 5/7 (71%) | 23/28 (82%) 22/24 (92%) 25/30 (83%) 22/26 (85%) |
|FIRST INCIDENCE (DAYS) | 462 441 387 422 | 502 469 536 571 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.439N P=0.369 P=0.544N P=0.531 | P=0.423N P=0.168 P=0.463 P=0.485 |
|INCIDENTAL TUMOR | P=0.196N P=0.382 P=0.510 P=0.335N | P=0.519N P=0.248 P=0.378 P=0.522 |
|LOGISTIC REGRESSION | P=0.323N P=0.282 P=0.363 P=0.487N | P=0.517N P=0.277 P=0.359 P=0.504 |
|COCHRAN-ARMITAGE | P=0.396N | P=0.450N |
|FISHER EXACT | P=0.288 P=0.410 P=0.584N | P=0.353 P=0.252 P=0.558N |
|=================================================================================================================================|
| |
|Prostate |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | |
|ADJUSTED (b) | 0.0% 0.0% 20.9% 0.0% | |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | |
|FIRST INCIDENCE (DAYS) | --- --- 701 --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.551 (e) P=0.243 (e) | |
|INCIDENTAL TUMOR | P=0.542 (e) P=0.244 (e) | |
|LOGISTIC REGRESSION | P=0.542 (e) P=0.254 (e) | |
|COCHRAN-ARMITAGE | P=0.546 | |
|FISHER EXACT | (e) P=0.253 (e) | |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 2/50 (4%) 9/50 (18%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 37.5% 33.4% 10.5% 50.7% | 7.1% 4.2% 0.0% 7.4% |
|TERMINAL (d) | 3/8 (38%) 1/5 (20%) 0/7 (0%) 1/7 (14%) | 2/28 (7%) 1/24 (4%) 0/30 (0%) 2/27 (7%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 591 669 526 | 733 (T) 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * P=0.365 P=0.509N P=0.055 | P=0.588 P=0.554N P=0.223N P=0.683 |
|INCIDENTAL TUMOR | P=0.029 * P=0.384 P=0.503N P=0.053 | P=0.588 P=0.554N P=0.223N P=0.683 |
|LOGISTIC REGRESSION | P=0.027 * P=0.506 P=0.457N P=0.053 | P=0.588 P=0.554N P=0.223N P=0.683 |
|COCHRAN-ARMITAGE | P=0.031 * | P=0.571 |
|FISHER EXACT | P=0.500 P=0.500N P=0.061 | P=0.500N P=0.247N P=0.691N |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 1/50 (2%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.0% 40.6% 11.1% 22.4% | 3.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 1/5 (20%) 0/7 (0%) 1/7 (14%) | 1/28 (4%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 715 681 723 621 | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478 P=0.149 P=0.727N P=0.278 | P=0.338N P=0.531N P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.475 P=0.218 P=0.722N P=0.330 | P=0.338N P=0.531N P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.457 P=0.162 P=0.746N P=0.299 | P=0.338N P=0.531N P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.470 | P=0.345N |
|FISHER EXACT | P=0.181 P=0.753N P=0.309 | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 6/50 (12%) 1/50 (2%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.0% 43.6% 11.1% 22.4% | 3.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 1/5 (20%) 0/7 (0%) 1/7 (14%) | 1/28 (4%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 715 489 723 621 | 733 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.495N P=0.053 P=0.727N P=0.278 | P=0.338N P=0.531N P=0.486N P=0.507N |
|INCIDENTAL TUMOR | P=0.499N P=0.075 P=0.722N P=0.330 | P=0.338N P=0.531N P=0.486N P=0.507N |
|LOGISTIC REGRESSION | P=0.504N P=0.060 P=0.746N P=0.299 | P=0.338N P=0.531N P=0.486N P=0.507N |
|COCHRAN-ARMITAGE | P=0.505N | P=0.345N |
|FISHER EXACT | P=0.056 P=0.753N P=0.309 | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 4.9% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 0/28 (0%) 0/24 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- 489 --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.254 (e) (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.277N P=0.236 (e) (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.297N P=0.240 (e) (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.280N | (e) |
|FISHER EXACT | P=0.247 (e) (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 7/50 (14%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 37.5% 7.5% 10.5% 39.0% | 0.0% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 3/8 (38%) 0/5 (0%) 0/7 (0%) 1/7 (14%) | 0/28 (0%) 1/24 (4%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 591 669 526 | --- 733 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042 * P=0.605N P=0.509N P=0.131 | P=0.457N P=0.469 (e) (e) |
|INCIDENTAL TUMOR | P=0.050 * P=0.616N P=0.503N P=0.138 | P=0.457N P=0.469 (e) (e) |
|LOGISTIC REGRESSION | P=0.048 * P=0.492N P=0.457N P=0.152 | P=0.457N P=0.469 (e) (e) |
|COCHRAN-ARMITAGE | P=0.050 * | P=0.464N |
|FISHER EXACT | P=0.500N P=0.500N P=0.159 | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 2/50 (4%) 8/50 (16%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 37.5% 33.4% 10.5% 44.6% | 7.1% 4.2% 0.0% 3.7% |
|TERMINAL (d) | 3/8 (38%) 1/5 (20%) 0/7 (0%) 1/7 (14%) | 2/28 (7%) 1/24 (4%) 0/30 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 591 669 526 | 733 (T) 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058 P=0.365 P=0.509N P=0.084 | P=0.358N P=0.554N P=0.223N P=0.513N |
|INCIDENTAL TUMOR | P=0.061 P=0.384 P=0.503N P=0.087 | P=0.359N P=0.554N P=0.223N P=0.513N |
|LOGISTIC REGRESSION | P=0.058 P=0.506 P=0.457N P=0.092 | P=0.359N P=0.554N P=0.223N P=0.513N |
|COCHRAN-ARMITAGE | P=0.064 | P=0.373N |
|FISHER EXACT | P=0.500 P=0.500N P=0.100 | P=0.500N P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/50 (4%) 8/50 (16%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 37.5% 16.8% 10.5% 44.6% | 3.6% 4.2% 0.0% 3.7% |
|TERMINAL (d) | 3/8 (38%) 0/5 (0%) 0/7 (0%) 1/7 (14%) | 1/28 (4%) 1/24 (4%) 0/30 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 591 669 526 | 733 (T) 733 (T) --- 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036 * P=0.568 P=0.509N P=0.084 | P=0.580N P=0.728 P=0.486N P=0.754 |
|INCIDENTAL TUMOR | P=0.037 * P=0.591 P=0.503N P=0.087 | P=0.580N P=0.728 P=0.486N P=0.754 |
|LOGISTIC REGRESSION | P=0.036 * P=0.660N P=0.457N P=0.092 | P=0.580N P=0.728 P=0.486N P=0.754 |
|COCHRAN-ARMITAGE | P=0.039 * | P=0.591N |
|FISHER EXACT | P=0.661N P=0.500N P=0.100 | P=0.753N P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 23/50 (46%) 31/50 (62%) 32/50 (64%) | |
|ADJUSTED (b) | 100.0% 84.1% 88.9% 95.9% | |
|TERMINAL (d) | 8/8 (100%) 2/5 (40%) 4/7 (57%) 6/7 (86%) | |
|FIRST INCIDENCE (DAYS) | 462 537 442 372 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.128 P=0.401N P=0.383 P=0.220 | |
|INCIDENTAL TUMOR | P=0.101 P=0.283N P=0.309 P=0.280 | |
|LOGISTIC REGRESSION | P=0.065 P=0.226N P=0.252 P=0.235 | |
|COCHRAN-ARMITAGE | P=0.060 | |
|FISHER EXACT | P=0.274N P=0.272 P=0.208 | |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 8/50 (16%) 2/50 (4%) 1/50 (2%) | 5/50 (10%) 5/50 (10%) 5/50 (10%) 2/50 (4%) |
|ADJUSTED (b) | 2.4% 44.4% 15.2% 2.6% | 15.8% 19.4% 16.7% 5.4% |
|TERMINAL (d) | 0/8 (0%) 1/5 (20%) 0/7 (0%) 0/7 (0%) | 3/28 (11%) 4/24 (17%) 5/30 (17%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 543 441 697 583 | 667 681 733 (T) 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105N P=0.022 * P=0.540 P=0.740N | P=0.148N P=0.534 P=0.591N P=0.246N |
|INCIDENTAL TUMOR | P=0.102N P=0.024 * P=0.591 P=0.749 | P=0.143N P=0.581 P=0.572N P=0.218N |
|LOGISTIC REGRESSION | P=0.100N P=0.019 * P=0.510 P=0.744 | P=0.157N P=0.586 P=0.583N P=0.230N |
|COCHRAN-ARMITAGE | P=0.100N | P=0.159N |
|FISHER EXACT | P=0.017 * P=0.508 P=0.747N | P=0.630N P=0.630N P=0.218N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 3/50 (6%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 16.7% 16.3% 3.4% | 0.0% 4.0% 6.7% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 1/7 (14%) 0/7 (0%) | 0/28 (0%) 0/24 (0%) 2/30 (7%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 674 653 520 621 | --- 727 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.434N P=0.346 P=0.497 P=0.725 | P=0.581N P=0.477 P=0.253 (e) |
|INCIDENTAL TUMOR | P=0.411N P=0.438 P=0.547 P=0.715N | P=0.586N P=0.519 P=0.253 (e) |
|LOGISTIC REGRESSION | P=0.402N P=0.320 P=0.508 P=0.755N | P=0.590N P=0.479 P=0.253 (e) |
|COCHRAN-ARMITAGE | P=0.407N | P=0.591N |
|FISHER EXACT | P=0.316 P=0.508 P=0.747N | P=0.500 P=0.247 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 11/50 (22%) 4/50 (8%) 2/50 (4%) | 5/50 (10%) 6/50 (12%) 7/50 (14%) 2/50 (4%) |
|ADJUSTED (b) | 7.9% 53.7% 29.0% 5.9% | 15.8% 22.6% 23.3% 5.4% |
|TERMINAL (d) | 0/8 (0%) 1/5 (20%) 1/7 (14%) 0/7 (0%) | 3/28 (11%) 4/24 (17%) 7/30 (23%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 543 441 520 583 | 667 681 733 (T) 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.106N P=0.015 * P=0.365 P=0.679 | P=0.150N P=0.401 P=0.423 P=0.246N |
|INCIDENTAL TUMOR | P=0.092N P=0.018 * P=0.432 P=0.670N | P=0.145N P=0.455 P=0.441 P=0.218N |
|LOGISTIC REGRESSION | P=0.088N P=0.010 ** P=0.348 P=0.694 | P=0.159N P=0.447 P=0.434 P=0.230N |
|COCHRAN-ARMITAGE | P=0.090N | P=0.162N |
|FISHER EXACT | P=0.008 ** P=0.349 P=0.684N | P=0.500 P=0.380 P=0.218N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 12.5% 24.2% 4.8% 2.6% | 3.6% 4.2% 5.3% 3.7% |
|TERMINAL (d) | 1/8 (13%) 1/5 (20%) 0/7 (0%) 0/7 (0%) | 1/28 (4%) 1/24 (4%) 1/30 (3%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 678 671 583 | 733 (T) 733 (T) 378 733 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.510N P=0.410 P=0.759N P=0.758 | P=0.581 P=0.728 P=0.516 P=0.754 |
|INCIDENTAL TUMOR | P=0.457N P=0.431 P=0.748N P=0.746N | P=0.565 P=0.728 P=0.415 P=0.754 |
|LOGISTIC REGRESSION | P=0.480N P=0.488 P=0.745N P=0.755N | P=0.576 P=0.728 P=0.506 P=0.754 |
|COCHRAN-ARMITAGE | P=0.479N | P=0.571 |
|FISHER EXACT | P=0.508 P=0.747N P=0.747N | P=0.753N P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 12/50 (24%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | | 32.4% 36.9% 23.2% 22.5% |
|TERMINAL (d) | | 8/28 (29%) 6/24 (25%) 5/30 (17%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | | 665 611 613 654 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.133N P=0.291 P=0.337N P=0.340N |
|INCIDENTAL TUMOR | | P=0.142N P=0.395 P=0.326N P=0.314N |
|LOGISTIC REGRESSION | | P=0.144N P=0.365 P=0.337N P=0.330N |
|COCHRAN-ARMITAGE | | P=0.142N |
|FISHER EXACT | | P=0.405 P=0.398N P=0.298N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 11/50 (22%) 12/50 (24%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | | 33.9% 36.9% 23.2% 22.5% |
|TERMINAL (d) | | 8/28 (29%) 6/24 (25%) 5/30 (17%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | | 527 611 613 654 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.102N P=0.378 P=0.254N P=0.260N |
|INCIDENTAL TUMOR | | P=0.111N P=0.481 P=0.280N P=0.241N |
|LOGISTIC REGRESSION | | P=0.110N P=0.472 P=0.268N P=0.242N |
|COCHRAN-ARMITAGE | | P=0.106N |
|FISHER EXACT | | P=0.500 P=0.306N P=0.218N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 31/50 (62%) 31/50 (62%) 27/50 (54%) | 17/50 (34%) 18/50 (36%) 16/50 (32%) 17/50 (34%) |
|ADJUSTED (b) | 94.9% 95.4% 95.1% 79.9% | 42.6% 45.0% 40.8% 43.6% |
|TERMINAL (d) | 7/8 (88%) 4/5 (80%) 6/7 (86%) 3/7 (43%) | 7/28 (25%) 5/24 (21%) 8/30 (27%) 7/27 (26%) |
|FIRST INCIDENCE (DAYS) | 514 441 264 502 | 443 541 378 434 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.449N P=0.235 P=0.346 P=0.515 | P=0.471N P=0.399 P=0.424N P=0.509 |
|INCIDENTAL TUMOR | P=0.378N P=0.248 P=0.263 P=0.496N | P=0.490 P=0.524N P=0.511N P=0.516 |
|LOGISTIC REGRESSION | P=0.406N P=0.276 P=0.265 P=0.554N | P=0.491 P=0.561N P=0.506N P=0.575N |
|COCHRAN-ARMITAGE | P=0.426N | P=0.480N |
|FISHER EXACT | P=0.272 P=0.272 P=0.579N | P=0.500 P=0.500N P=0.583N |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 11.0% 2.6% 5.0% 22.2% | 0.0% 0.0% 3.3% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/5 (0%) 0/7 (0%) 0/7 (0%) | 0/28 (0%) 0/24 (0%) 1/30 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 462 574 678 583 | --- --- 733 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.067 P=0.507N P=0.472N P=0.227 | P=0.662 (e) P=0.514 (e) |
|INCIDENTAL TUMOR | P=0.083 P=0.470N P=0.424N P=0.253 | P=0.662 (e) P=0.514 (e) |
|LOGISTIC REGRESSION | P=0.065 P=0.499N P=0.500N P=0.214 | P=0.662 (e) P=0.514 (e) |
|COCHRAN-ARMITAGE | P=0.066 | P=0.655 |
|FISHER EXACT | P=0.500N P=0.500N P=0.218 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 47/50 (94%) 48/50 (96%) 49/50 (98%) | 41/50 (82%) 43/50 (86%) 45/50 (90%) 41/50 (82%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 97.6% 100.0% 97.8% 95.3% |
|TERMINAL (d) | 8/8 (100%) 5/5 (100%) 7/7 (100%) 7/7 (100%) | 27/28 (96%) 24/24 (100%) 29/30 (97%) 25/27 (93%) |
|FIRST INCIDENCE (DAYS) | 462 441 387 372 | 502 469 378 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.430 P=0.529 P=0.487N P=0.440 | P=0.427N P=0.150 P=0.497 P=0.453 |
|INCIDENTAL TUMOR | P=0.520N P=0.257N P=0.443N P=0.419N | P=0.467 P=0.345 P=0.342 P=0.477 |
|LOGISTIC REGRESSION | P=0.431 P=0.467N P=0.731 P=0.806 | P=0.467 P=0.327 P=0.304 P=0.467 |
|COCHRAN-ARMITAGE | P=0.280 | P=0.512N |
|FISHER EXACT | P=0.500N P=0.691N P=0.500 | P=0.393 P=0.194 P=0.602N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 35/50 (70%) 32/50 (64%) 33/50 (66%) | 26/50 (52%) 28/50 (56%) 26/50 (52%) 23/50 (46%) |
|ADJUSTED (b) | 95.7% 96.1% 95.7% 92.3% | 60.1% 68.5% 61.1% 55.9% |
|TERMINAL (d) | 7/8 (88%) 4/5 (80%) 6/7 (86%) 5/7 (71%) | 12/28 (43%) 12/24 (50%) 14/30 (47%) 10/27 (37%) |
|FIRST INCIDENCE (DAYS) | 359 441 264 502 | 443 470 378 275 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.464N P=0.361 P=0.482N P=0.497 | P=0.256N P=0.295 P=0.461N P=0.449N |
|INCIDENTAL TUMOR | P=0.431N P=0.397 P=0.496N P=0.553 | P=0.294N P=0.459 P=0.476 P=0.401N |
|LOGISTIC REGRESSION | P=0.417N P=0.418 P=0.502N P=0.567N | P=0.316N P=0.431 P=0.564 P=0.403N |
|COCHRAN-ARMITAGE | P=0.437N | P=0.223N |
|FISHER EXACT | P=0.415 P=0.500N P=0.583N | P=0.421 P=0.579N P=0.345N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6 OZONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM | CONTROL 0.12 PPM 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 49/50 (98%) 49/50 (98%) 49/50 (98%) | 48/50 (96%) 48/50 (96%) 48/50 (96%) 46/50 (92%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 98.0% 100.0% 100.0% 97.9% |
|TERMINAL (d) | 8/8 (100%) 5/5 (100%) 7/7 (100%) 7/7 (100%) | 27/28 (96%) 24/24 (100%) 30/30 (100%) 26/27 (96%) |
|FIRST INCIDENCE (DAYS) | 359 441 264 372 | 443 469 378 275 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.503 P=0.483 P=0.487N P=0.485 | P=0.335N P=0.268 P=0.364N P=0.559 |
|INCIDENTAL TUMOR | P=0.338N P=0.638N P=0.649N P=0.419N | P=0.491N P=0.718N P=0.748N P=0.595N |
|LOGISTIC REGRESSION | P=0.410N P=0.638N P=0.777 P=0.555N | P=0.531N P=0.660 P=0.675 P=0.588N |
|COCHRAN-ARMITAGE | P=0.627 | P=0.217N |
|FISHER EXACT | P=0.753N P=0.753N P=0.753N | P=0.691N P=0.691N P=0.339N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).