TDMS Study 88034-03 Pathology Tables
NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X | Degeneration, Fatty | 2 2 2 3 1 2 2| Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X X X X| Mixed Cell Focus | X X X | Necrosis | 2 | Bile Duct, Hyperplasia | 2 2 2 1 1 | Centrilobular, Necrosis | 2 2 | __________________________________________________________________________| Mesentery | | Hemorrhage | | Artery, Inflammation, Chronic Active | | Artery, Mineralization | | Fat, Necrosis | | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Hyperplasia | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 3 1 2 3 1 1 2 1 1 | Basophilic Focus | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X | Necrosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 1 1 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 1 1 1 2 2 1 1 1 2 1 1 2 1| Artery, Mineralization | | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 1 2 | Hypertrophy | 2 2 2 | Necrosis | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 1 1 | Pars Distalis, Hyperplasia | 2 2 3 2 2 1 3 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 2 1 2 1 1 1 1 2 1 1 2 1 2 1 1 2 2 1| Follicular Cell, Hyperplasia | 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + + + + + + + + M + + M + + + + M + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 2 | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | 2 | __________________________________________________________________________| Lymph Node | + + + + +| __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + M + + + + + M M + + M + + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + M + + + + + M + + M + M + + + +| Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 | Hemorrhage | | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + + M + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Atypical | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | 2 | Prepuce, Inflammation, Acute | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | Hemorrhage | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Meninges, Hyperplasia | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | Mineralization | 2 | Epiglottis, Metaplasia, Squamous | 1 4 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 | Mineralization | 2 | Alveolar Epithelium, Hyperplasia | 2 1 1 | Artery, Mediastinum, Mineralization | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Thrombosis | 1 1 3 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | | Lateral Wall, Hyperplasia | 2 | Lateral Wall, Metaplasia, Squamous | | Nasopharyngeal Duct, Inflammation, | | Acute | 3 | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| DAY ON TEST | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0| | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 1 1 1 2 2 1 1 1 1 1 2 1 2 2 2 2 2 2 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Mineralization | | Nephropathy | 4 1 2 2 1 2 1 3 1 1 2 1 3 1 3 3 1 2 3 2 1 2 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | I + + + + + + + + + + + + I I + I + I + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X| Degeneration, Fatty | 1 3 2 1 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X | Necrosis | | Bile Duct, Hyperplasia | 1 1 1 1 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + + + + | Hemorrhage | 2 | Artery, Inflammation, Chronic Active | 4 | Artery, Mineralization | 4 | Fat, Necrosis | 2 3 | __________________________________________________________________________| Oral Mucosa | | Pharyngeal, Hyperplasia | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 1 2 2 1 1 2 2 2 | Basophilic Focus | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Necrosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 4 1 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 4 | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 1 1 1 2 2 1 1 3 3 2 1 1| Artery, Mineralization | 4 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 2 2 2 4 2 1 2 3 1 1 2 | Hypertrophy | 2 2 2 2 2 2 2 1 | Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia | 2 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Pars Distalis, Hyperplasia | 2 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 1 1 2 1 1 1 2 2 2 2 2 1 1 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Cyst | | Inflammation, Granulomatous | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + M M + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 4 | Hemorrhage | 3 | Necrosis | 3 | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Atypical | 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3 | Inflammation, Chronic Active | | Prepuce, Inflammation, Acute | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 | Hyperostosis | 3 3 2 | __________________________________________________________________________| Skeletal Muscle | + | Hemorrhage | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Meninges, Hyperplasia | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | Epiglottis, Metaplasia, Squamous | 4 4 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 1 1 | Mineralization | 4 | Alveolar Epithelium, Hyperplasia | 2 | Artery, Mediastinum, Mineralization | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | Thrombosis | 1 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 | Lateral Wall, Hyperplasia | 2 | Lateral Wall, Metaplasia, Squamous | 3 2 | Nasopharyngeal Duct, Inflammation, | | Acute | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3| | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 1 2 1 2 1 1 1 1 2 2 2 2 2 2 2 2 1 1 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Mineralization | 4 | Nephropathy | 3 3 2 1 2 3 3 1 1 2 1 2 3 3 3 3 2 3 4 4 3 3 3| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + I + + | 43 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + | 50 | Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + | 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + | 50 | Angiectasis | 1 | 1 1.0| Basophilic Focus | X X | 38 | Clear Cell Focus | | 6 | Degeneration, Fatty | 3 | 13 2.0| Eosinophilic Focus | | 3 | Hepatodiaphragmatic Nodule | X | 7 | Mixed Cell Focus | | 5 | Necrosis | | 1 2.0| Bile Duct, Hyperplasia | 2 | 10 1.4| Centrilobular, Necrosis | | 2 2.0| __________________________________________________________________________|____________| Mesentery | | 4 | Hemorrhage | | 1 2.0| Artery, Inflammation, Chronic Active | | 1 4.0| Artery, Mineralization | | 1 4.0| Fat, Necrosis | | 2 2.5| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + | 50 | Atrophy | 1 | 22 1.6| Basophilic Focus | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 50 | Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 50 | Diverticulum | | 1 | Necrosis | | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 50 | Mineralization | | 5 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Mineralization | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + | 50 | Cardiomyopathy | 2 2 1 | 37 1.6| Artery, Mineralization | | 1 4.0| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + | 50 | Hyperplasia | 1 | 21 1.8| Hypertrophy | 1 | 12 1.8| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + | 50 | Hyperplasia | | 9 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + | 49 | Hyperplasia | 2 | 3 2.3| __________________________________________________________________________|____________| Pituitary Gland | + + + + | 50 | Cyst | | 5 1.6| Pars Distalis, Hyperplasia | 2 | 13 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + | 50 | C-Cell, Hyperplasia | 1 2 1 | 43 1.4| Follicular Cell, Hyperplasia | | 2 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + | 43 | __________________________________________________________________________|____________| Ovary | + + + + | 50 | Angiectasis | | 1 2.0| Cyst | | 1 2.0| Inflammation, Granulomatous | | 2 3.5| __________________________________________________________________________|____________| Uterus | + + + + | 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 50 | Hyperplasia, Reticulum Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | | 5 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + | 43 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + | 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + | 39 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + | 50 | Fibrosis | | 2 2.5| Hematopoietic Cell Proliferation | | 2 3.5| Hemorrhage | | 1 3.0| Necrosis | | 2 2.5| __________________________________________________________________________|____________| Thymus | + + + + | 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + | 50 | Hyperplasia, Atypical | | 4 2.3| __________________________________________________________________________|____________| Skin | + + + + | 50 | Hyperkeratosis | | 1 3.0| Inflammation, Chronic Active | | 1 2.0| Prepuce, Inflammation, Acute | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 50 | Fibrous Osteodystrophy | | 1 4.0| Hyperostosis | | 3 2.7| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 50 | Hemorrhage | | 1 1.0| Meninges, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + | 50 | Inflammation, Acute | | 1 3.0| Mineralization | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 6| 6| 4| | | DAY ON TEST | 3| 3| 6| 0| 0| 4| | | | 5| 3| 2| 2| 2| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Epiglottis, Metaplasia, Squamous | | 4 3.3| __________________________________________________________________________|____________| Lung | + + + + | 50 | Inflammation, Chronic Active | | 5 1.2| Mineralization | | 2 3.0| Alveolar Epithelium, Hyperplasia | | 4 1.5| Artery, Mediastinum, Mineralization | | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + | 50 | Inflammation, Suppurative | | 3 1.0| Thrombosis | | 6 1.5| Goblet Cell, Lateral Wall, | | | Hyperplasia | | 1 2.0| Lateral Wall, Hyperplasia | | 2 2.0| Lateral Wall, Metaplasia, Squamous | | 2 2.5| Nasopharyngeal Duct, Inflammation, | | | Acute | | 1 3.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 1 1 2 | 50 1.5| __________________________________________________________________________|____________| Trachea | + + + + | 50 | Inflammation, Acute | | 1 3.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 50 | Infarct | | 1 2.0| Mineralization | | 1 4.0| Nephropathy | 4 2 2 | 49 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X X X X X| Clear Cell Focus | X X| Degeneration, Fatty | 4 3 | Eosinophilic Focus | | Hepatodiaphragmatic Nodule | X X X X | Mixed Cell Focus | X X X X X X | Bile Duct, Hyperplasia | 1 2 1 | Centrilobular, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 1 2 2 1 | Basophilic Focus | X | Metaplasia, Hepatocyte | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 2 1 | Necrosis | | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | | Developmental Malformation | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 1 1 1 2 1 2 1 1 1 2 1 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 1 3 1 1 1 3 1| Hypertrophy | 2 1 1 3 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + A + + + + + + +| Pars Distalis, Hyperplasia | 2 4 4 1 | Pars Intermedia, Hyperplasia | 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 1 1 2 2 2 1 3 2 1 2 1 1 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 4 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | 1 | __________________________________________________________________________| Lymph Node | + | Renal, Hemorrhage | | Renal, Inflammation, Granulomatous | 1 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + M M M + M M + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + M + + + + +| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Necrosis | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + M + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 2 2| Inflammation, Suppurative | 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 3| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Epiglottis, Metaplasia, Squamous | 2 4 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Inflammation, Suppurative | | Alveolar Epithelium, Hyperplasia | 2 | Alveolar Epithelium, Metaplasia | 1 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | Necrosis | | Thrombosis | 3 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1| Lateral Wall, Hyperplasia | 1 2 2 1| Lateral Wall, Metaplasia, Squamous | 1 1 2 2 1| Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2| Olfactory Epithelium, Metaplasia | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Degeneration | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 2 2 2 2 3 2 1 1 2 1 2 3 2 2 2 3 3 3 2 3| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Vacuolization | | Cytoplasmic | | __________________________________________________________________________| Urinary Bladder | + I + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Necrosis | | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X | Degeneration, Fatty | 4 2 3| Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X X X X | Bile Duct, Hyperplasia | 1 2 3 1 1 2 3 | Centrilobular, Necrosis | 1 1 2 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | 3 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 2 1 2 | Basophilic Focus | | Metaplasia, Hepatocyte | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | 1 3 2 2 | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 2 1 2 2 2 1 1 2 2 1 1 1 | Atrium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 1 2 1 2 | Hypertrophy | 2 1 2 1 3 2 1 3| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 2 2 3 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 2 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 3 1 1 2 2 2 2 1 2 2 1 1 2 2 3 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | 2 | __________________________________________________________________________| Lymph Node | + + + + + + +| Renal, Hemorrhage | 2 | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + M + M + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + +| Infiltration Cellular, Plasma Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + M + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M| Galactocele | | Inflammation, Suppurative | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3 | Inflammation, Chronic Active | 2 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | Epiglottis, Metaplasia, Squamous | 4 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Inflammation, Suppurative | 3 | Alveolar Epithelium, Hyperplasia | 1 1 1| Alveolar Epithelium, Metaplasia | 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 2 | Necrosis | 3 | Thrombosis | 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | | Lateral Wall, Hyperplasia | 1 2 1 2 | Lateral Wall, Metaplasia, Squamous | 1 1 1 1 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 2 1 1 1| Olfactory Epithelium, Metaplasia | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 2 1 3 3 3 2 3 3 4 2 2 2 2 1 2 2 1 2 2| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| DAY ON TEST | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1| | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Vacuolization | | Cytoplasmic | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Necrosis | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + I | 48 | Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Angiectasis | | 2 1.5| Basophilic Focus | X X X X | 34 | Clear Cell Focus | | 5 | Degeneration, Fatty | 3 | 6 3.2| Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | | 6 | Mixed Cell Focus | | 13 | Bile Duct, Hyperplasia | 1 | 11 1.6| Centrilobular, Necrosis | | 4 1.3| __________________________________________________________________________|____________| Mesentery | | 5 | Fat, Necrosis | | 5 2.2| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Atrophy | 1 | 14 1.4| Basophilic Focus | | 1 | Metaplasia, Hepatocyte | | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Necrosis | 3 | 4 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Mineralization | 1 | 4 1.3| Necrosis | | 4 2.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + | 50 | Cardiomyopathy | 1 1 | 32 1.3| Atrium, Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Hyperplasia | 2 | 22 1.7| Hypertrophy | | 13 1.8| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Hyperplasia | 2 | 10 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 48 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 49 | Pars Distalis, Hyperplasia | 2 2 | 8 2.5| Pars Intermedia, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | C-Cell, Hyperplasia | 1 1 2 | 38 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 50 | Hyperplasia | | 1 3.0| Inflammation, Chronic Active | | 3 3.0| __________________________________________________________________________|____________| Ovary | + + + + + | 50 | Cyst | 2 | 2 2.0| __________________________________________________________________________|____________| Uterus | + + + + + | 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | Hyperplasia, Reticulum Cell | | 2 1.5| __________________________________________________________________________|____________| Lymph Node | + | 9 | Renal, Hemorrhage | | 1 2.0| Renal, Inflammation, Granulomatous | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M + + | 39 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Infiltration Cellular, Plasma Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 50 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 46 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Fibrosis | | 4 2.5| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | + M + M + | 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 49 | Galactocele | | 2 2.0| Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + | 50 | Hyperkeratosis | | 1 3.0| Inflammation, Chronic Active | | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Hyperostosis | | 2 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Inflammation, Acute | | 1 3.0| Epiglottis, Metaplasia, Squamous | 3 1 | 5 2.8| __________________________________________________________________________|____________| Lung | + + + + + | 50 | Inflammation, Chronic Active | 1 | 3 1.3| Inflammation, Suppurative | | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 | 5 1.4| Alveolar Epithelium, Metaplasia | | 6 1.0| __________________________________________________________________________|____________| Nose | + + + + + | 50 | Inflammation, Suppurative | 2 | 6 1.5| Necrosis | | 1 3.0| Thrombosis | | 3 2.7| Goblet Cell, Lateral Wall, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 5| 7| 7| | | DAY ON TEST | 3| 0| 6| 8| 3| 3| | | | 3| 2| 7| 3| 4| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hyperplasia | | 2 1.0| Lateral Wall, Hyperplasia | | 8 1.5| Lateral Wall, Metaplasia, Squamous | 2 | 11 1.4| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 1 2 1 | 48 1.2| Olfactory Epithelium, Metaplasia | | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Degeneration | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Nephropathy | 3 1 1 2 2 | 48 2.1| Renal Tubule, Vacuolization | | | Cytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 49 | Hemorrhage | 3 | 1 3.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + I + + + + + + + + + I + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X | Degeneration, Fatty | 2 2 2 2 | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X X | Necrosis | 2 | Bile Duct, Hyperplasia | 2 1 1 2 1 2 | Centrilobular, Necrosis | 2 1 | Serosa, Fibrosis | 2 | __________________________________________________________________________| Mesentery | + + + + + | Artery, Inflammation, Chronic Active | 2 | Fat, Necrosis | 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 2 2 1 1| Basophilic Focus | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Mineralization | 1 | Necrosis | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Necrosis | | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 2 2 3 1 2 2 3 1 1 2 1 1 2 2| Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 1 2 1 3 2 1 2 2| Hypertrophy | 2 2 2 2 2 3| Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + M + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Pars Distalis, Hyperplasia | 3 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 3 2 1 2 2 1 2 2 1 2 1 1| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + I + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Inflammation, Chronic Active | 3 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 2 3 2 3 1 | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | M + + + M + + M + M + + + + + + + + M + + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + M M + M +| Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Hematopoietic Cell Proliferation | 2 3 | Capsule, Fibrosis | 1 | __________________________________________________________________________| Thymus | M M + + + + + + + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3| | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Atypical | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 2 4 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 2 | Alveolar Epithelium, Metaplasia | 2 1 2 1 1 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 1| Alveolus, Infiltration Cellular, | | Histiocyte | 2 1 1 1 1 1 1 2 2 1 2 1 1 1 1 | Interstitium, Fibrosis | 1 1 1 1 1 1 2 2 2 2 2 2 1 2 2 2 2 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Thrombosis | 4 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 1 2 2 2 1 1 2 1 2| Lateral Wall, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 1 2 1 2 3 2 1 1 2 2 2| Lateral Wall, Metaplasia, Squamous | 1 3 1 3 2 1 2 2 3 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 1 1 3 1 2 2 2 2 2 2 2 1 1 1 3 1 2 3 2 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy | 2 3 1 3 3 2 2 3 3 4 3 4 3 1 2 1 2 3 1 2 3| Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + I + I + + + + + + + + + + + + + + + I +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X| Clear Cell Focus | X X | Degeneration, Fatty | 3 2 2 | Hepatodiaphragmatic Nodule | X X| Mixed Cell Focus | X X X | Necrosis | | Bile Duct, Hyperplasia | 2 3 | Centrilobular, Necrosis | 2 | Serosa, Fibrosis | | __________________________________________________________________________| Mesentery | + + + + +| Artery, Inflammation, Chronic Active | | Fat, Necrosis | 2 3 2 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 1 1 1 2 | Basophilic Focus | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Mineralization | 1 | Necrosis | 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 | Necrosis | 2 3 | __________________________________________________________________________| Tooth | | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 1 1 1 1 1 2 2 2 1 2 1| Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 2 4 2 2 4| Hypertrophy | 1 2 1 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 1 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + M + + + + + + + + + + +| Hyperplasia | 1 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 | Pars Distalis, Hyperplasia | 3 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 1 1 2 2 2 1 2 1 1 4 1| Follicular Cell, Hyperplasia | 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + M + + + + + + + + + +| Cyst | 1 2 3 | Inflammation, Granulomatous | | __________________________________________________________________________| Uterus | + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + M + + M M + + + + + + + + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + M +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + M M M + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | | Capsule, Fibrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Atypical | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 1 2 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 1 1 1 4 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 2 1 | Alveolar Epithelium, Metaplasia | 2 1 1 1 1 1 2 2 2 2 2 2 2 2 1 2 2 1 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1| Interstitium, Fibrosis | 2 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 2 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Thrombosis | 1 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 2 2 2 1 2 1 2 1 2 1 1 2 2 1 1 2 1 2| Lateral Wall, Hyperplasia | 1 2 2 2 1 2 2 2 1 1 1 2 1 2 2 3 2 1 2 3 1| Lateral Wall, Metaplasia, Squamous | 1 1 1 2 3 1 2 1 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 2 3 2 2 2 1 2 2 1 3 2 2 2 3 2 3 2 2 3| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy | 2 3 3 3 1 2 1 3 2 3 1 3 1 3 1 2 3 2 2 2 3| Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 45 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Parasite Metazoan | X X X | 8 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 48 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Basophilic Focus | X X X X X | 35 | Clear Cell Focus | X | 5 | Degeneration, Fatty | 3 | 8 2.3| Hepatodiaphragmatic Nodule | X | 6 | Mixed Cell Focus | X | 6 | Necrosis | | 1 2.0| Bile Duct, Hyperplasia | | 8 1.8| Centrilobular, Necrosis | | 3 1.7| Serosa, Fibrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + | 11 | Artery, Inflammation, Chronic Active | | 1 2.0| Fat, Necrosis | 3 | 9 2.2| __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Atrophy | 1 1 2 2 | 18 1.3| Basophilic Focus | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Hyperplasia, Squamous | | 1 2.0| Mineralization | | 2 1.0| Necrosis | 4 | 4 3.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Mineralization | 2 2 | 5 1.6| Necrosis | | 2 2.5| __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 2 1 1 | 34 1.6| Atrium, Thrombosis | | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Hyperplasia | 1 2 2 | 22 1.9| Hypertrophy | | 9 1.9| Vacuolization Cytoplasmic | | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Hyperplasia | | 11 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 46 | Hyperplasia | | 3 1.7| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Cyst | | 1 1.0| Pars Distalis, Hyperplasia | | 7 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Hyperplasia | 1 1 1 1 2 | 34 1.6| Follicular Cell, Hyperplasia | | 4 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + | 47 | Hyperplasia | 2 | 2 3.0| Inflammation, Chronic Active | | 2 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + | 49 | Cyst | 2 | 11 2.2| Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + | 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + | 3 | Renal, Inflammation, Granulomatous | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M M + | 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + + + | 41 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibrosis | | 2 2.0| Hematopoietic Cell Proliferation | | 2 2.5| Capsule, Fibrosis | | 1 1.0| __________________________________________________________________________|____________| Thymus | + M + + + + | 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 50 | Hyperplasia, Atypical | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Inflammation, Chronic Active | | 3 1.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Hyperostosis | 3 | 6 2.3| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | Epiglottis, Metaplasia, Squamous | 3 2 3 | 9 2.3| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Alveolar Epithelium, Hyperplasia | 2 2 | 5 1.8| Alveolar Epithelium, Metaplasia | 2 2 2 2 2 2 | 48 1.7| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 1 1 1 1 | 31 1.2| Interstitium, Fibrosis | 1 2 2 1 1 1 | 42 1.4| __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Inflammation, Suppurative | 1 | 2 1.0| Thrombosis | | 4 1.8| Goblet Cell, Lateral Wall, | | | Hyperplasia | 2 2 1 2 2 2 | 45 1.7| Lateral Wall, Hyperplasia | 2 2 1 2 2 2 | 48 1.8| Lateral Wall, Metaplasia, Squamous | 2 3 1 | 21 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 2| 3| 6| 3| 3| | | | 8| 3| 5| 5| 5| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 3 2 2 2 | 50 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | 2 | 1 2.0| Nephropathy | 2 2 4 3 2 3 | 48 2.4| Renal Tubule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + I + + + I + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X | Degeneration, Fatty | 3 2 1 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X X X X| Mixed Cell Focus | X X X X| Regeneration | | Bile Duct, Hyperplasia | 2 1 2 1 | Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + | Artery, Inflammation, Chronic Active | 3 | Fat, Necrosis | 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 1 1 2 4 | Basophilic Focus | X | Artery, Inflammation | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Duct, Metaplasia, Squamous | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Hyperplasia, Squamous | 3 | Necrosis | 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | Mineralization | 2 1 1 1 | Necrosis | | __________________________________________________________________________| Tongue | | Hyperplasia | | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 1 2 2 3 2 2 1 2 1 1 1 2 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 | Hypertrophy | 2 2 | Mineralization | | Necrosis | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 1 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 4 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 1 2 1 2 2 1 1 2 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + I + + + + + + + + + + + + + + M +| Cyst | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hemorrhage | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | 1 | __________________________________________________________________________| Lymph Node | + | Renal, Hemorrhage | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 2 | Hemorrhage | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | Hyperostosis | 4 3 4 4 | __________________________________________________________________________| Skeletal Muscle | + + | Cyst | | Hemorrhage | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Meninges, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 4 | Epiglottis, Metaplasia, Squamous | 2 4 2 1 1 3 3 2 2 2 3 1 2 4 2 2 2| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia | 3 3 2 3 2 2 3 4 3 2 2 3 3 3 3 3 3 3 3 3 3| Alveolus, Infiltration Cellular, | | Histiocyte | 1 2 1 1 2 2 2 3 2 1 2 2 2 2 1 2 2 2 1| Interstitium, Fibrosis | 2 2 2 2 1 2 2 3 2 1 2 2 2 2 2 2 3 2 3 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 1 | Thrombosis | 4 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 2 3 2 2 2 2 2 3 2 3 3 1 3 2 3 3 3 2 2 3 3| Lateral Wall, Hyperplasia | 2 2 2 2 3 2 3 2 2 2 2 3 2 2 3 3 3 3 3 3 3 2| Lateral Wall, Metaplasia, Squamous | 2 3 2 2 2 2 2 3 3 2 2 2 1 1 2 3 2 3 2 2 3| Olfactory Epithelium, Degeneration, | | Hyaline | 3 3 4 3 3 4 4 4 2 4 2 3 3 3 4 3 1 3 4 4| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6| DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5| | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Retina, Atrophy | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hemorrhage | | Nephropathy | 4 1 2 2 2 2 2 2 2 4 1 2 3 2 2 3 2 2 2| Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + +| Cyst | | Parasite Metazoan | X X X X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 1| Basophilic Focus | X X X X X X X X X X X X X X X| Clear Cell Focus | | Degeneration, Fatty | 1 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X X X X X X | Mixed Cell Focus | X X X | Regeneration | 2 | Bile Duct, Hyperplasia | 1 2 2 2 2 1 | Centrilobular, Necrosis | | __________________________________________________________________________| Mesentery | + | Artery, Inflammation, Chronic Active | | Fat, Necrosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + M + + +| Atrophy | 1 2 2 2 1 1 3 2 1 2 2 | Basophilic Focus | | Artery, Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Duct, Metaplasia, Squamous | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X | Hyperplasia, Squamous | | Necrosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | 1 1 | Necrosis | 2 1 | __________________________________________________________________________| Tongue | + | Hyperplasia | 3 | __________________________________________________________________________| Tooth | | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 2 1 2 2 2 2 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 2 2 1 2 1| Hypertrophy | 2 3 | Mineralization | 2 | Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 2 2 2 4 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 3 1 1 2 2 1 1 1 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 3 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + A + + +| Cyst | 3 | Hemorrhage | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | 2 2 1| __________________________________________________________________________| Lymph Node | + + | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + M + + + M + + + + M + M +| __________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + + + + M| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | | Hemorrhage | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Hyperostosis | 4 3 | __________________________________________________________________________| Skeletal Muscle | | Cyst | | Hemorrhage | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Meninges, Hyperplasia | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Epiglottis, Metaplasia, Squamous | 1 3 1 2 3 2 2 1 3 4 1 4 3 2 2 2 3 4 3 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Alveolar Epithelium, Hyperplasia | 1 1 1 | Alveolar Epithelium, Metaplasia | 3 2 3 2 3 2 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3| Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 1 2 2 2 2 2 1 2 2 1 2 2 1 2 2 2| Interstitium, Fibrosis | 2 1 2 1 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Thrombosis | 1 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 3 3 2 3 2 2 2 3 2 3 3 3 3 2 2 3 3 2 2 2 3 2| Lateral Wall, Hyperplasia | 3 2 2 3 3 2 3 3 2 3 3 3 3 3 3 3 3 2 2 3 2 3| Lateral Wall, Metaplasia, Squamous | 2 2 2 1 2 2 2 1 2 1 3 1 2 2 1 1 2 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 3 1 3 4 2 3 4 4 2 3 3 3 4 4 3 3 4 3 3 3 3| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7| DAY ON TEST | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3| | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + | Cataract | 4 | Retina, Atrophy | 3 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | Hemorrhage | 4 | Nephropathy | 3 1 2 2 2 2 2 3 3 1 1 3 2 2 3 1 2 2 3 3 3| Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 49 | Cyst | | 1 3.0| Parasite Metazoan | | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 48 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Parasite Metazoan | X X | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + | 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + | 47 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Angiectasis | | 4 1.5| Basophilic Focus | X X X X X X | 38 | Clear Cell Focus | | 4 | Degeneration, Fatty | | 4 1.8| Eosinophilic Focus | | 2 | Hepatodiaphragmatic Nodule | X | 15 | Mixed Cell Focus | | 7 | Regeneration | | 1 2.0| Bile Duct, Hyperplasia | 2 | 11 1.6| Centrilobular, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 4 | Artery, Inflammation, Chronic Active | | 1 3.0| Fat, Necrosis | | 3 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + | 49 | Atrophy | 1 2 1 | 20 1.8| Basophilic Focus | | 1 | Artery, Inflammation | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | Duct, Metaplasia, Squamous | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Diverticulum | | 1 | Hyperplasia, Squamous | | 1 3.0| Necrosis | | 3 3.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Inflammation, Acute | | 1 2.0| Mineralization | 2 | 7 1.3| Necrosis | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tongue | | 1 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 1 1 2 1 2 | 30 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Hyperplasia | 2 2 2 2 | 23 1.9| Hypertrophy | 1 2 2 | 7 2.0| Mineralization | | 1 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Hyperplasia | | 5 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 49 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + M + + + | 49 | Pars Distalis, Hyperplasia | 2 | 10 2.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Hyperplasia | 1 1 1 1 1 | 31 1.4| Follicular Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + | 47 | Cyst | 3 | 1 3.0| Inflammation, Chronic Active | 3 | 4 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + | 49 | Cyst | | 1 3.0| Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Hyperplasia, Reticulum Cell | | 4 1.5| __________________________________________________________________________|____________| Lymph Node | | 3 | Renal, Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + | 43 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + | 46 | Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + + | 47 | __________________________________________________________________________|____________| Spleen | + + + + + + | 49 | Hematopoietic Cell Proliferation | | 2 2.5| Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + M + + + | 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 50 | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Fibrous Osteodystrophy | | 1 2.0| Hyperostosis | | 6 3.7| __________________________________________________________________________|____________| Skeletal Muscle | + | 3 | Cyst | 3 | 1 3.0| Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Meninges, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | Inflammation, Acute | | 1 4.0| Epiglottis, Metaplasia, Squamous | 2 2 2 3 1 4 | 43 2.3| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Mineralization | | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 1 | 6 1.0| Alveolar Epithelium, Metaplasia | 2 2 3 3 3 3 | 48 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| | | DAY ON TEST | 3| 1| 3| 8| 3| 3| | | | 3| 9| 4| 1| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 2 2 2 2 | 43 1.8| Interstitium, Fibrosis | 2 1 2 2 2 2 | 47 2.0| __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Inflammation, Suppurative | | 2 2.0| Thrombosis | | 3 2.3| Goblet Cell, Lateral Wall, | | | Hyperplasia | 3 4 3 3 3 3 | 50 2.5| Lateral Wall, Hyperplasia | 3 2 3 3 3 3 | 50 2.6| Lateral Wall, Metaplasia, Squamous | 1 2 1 1 1 1 | 45 1.9| Olfactory Epithelium, Degeneration, | | | Hyaline | 4 3 4 4 4 3 | 47 3.2| __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 2 3.5| Retina, Atrophy | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | | 1 4.0| Hemorrhage | | 1 4.0| Nephropathy | 2 1 1 2 2 2 | 46 2.1| Renal Tubule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Adenomatous | 3 | Necrosis | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Basophilic Focus | X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | 1 1 2 2 2 3 | Degeneration, Fatty | 2 3 2 2| Eosinophilic Focus | | Fibrosis | 2 | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous | | Mineralization | | Mixed Cell Focus | X X | Necrosis | 2 | Regeneration | 2 | Thrombosis | | Bile Duct, Hyperplasia | 1 1 2 2 2 3 2 2 3 1 1 2 1| Centrilobular, Necrosis | 2 2 | __________________________________________________________________________| Mesentery | + + + + | Thrombosis | | Artery, Inflammation, Chronic Active | | Artery, Mineralization | 3 | Fat, Necrosis | 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 1 3 3 2 3 2 1 2 1| Basophilic Focus | X | Hyperplasia | 2 | Artery, Inflammation | | Artery, Mineralization | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 3 | Inflammation, Acute | 3 3 | Mineralization | 2 | Necrosis | 3 4 4 2| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | 2 1 | Necrosis | 2 3| __________________________________________________________________________| Tooth | | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 3 2 2 2 1 2 3 2 2 3 2 3 1 2 1 1| Mineralization | | Artery, Mineralization | | Atrium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 2 2 2 2 1 2 | Hypertrophy | 2 4 2 | Necrosis | | Vacuolization Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 1 1 2 1 2 2 3 2 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 4 3 2 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Pars Distalis, Metaplasia, Osseous | 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | Follicular Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Inflammation, Chronic Active | 3 4 3 3 2 3 | Inflammation, Suppurative | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 4 3 3 2 4 | Artery, Inflammation, Chronic Active | 2 1 2 2 | Interstitial Cell, Hyperplasia | 1 1 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + | Iliac, Hemorrhage | | Renal, Angiectasis | 4 | Renal, Hemorrhage | 2 2 2 2 | __________________________________________________________________________| Lymph Node, Bronchial | M + + M M + + + M + + + + + + + + + + + + +| Hemorrhage | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + M M| Hemorrhage | | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + M + M + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 2 2 3 2 2 3 | Hematopoietic Cell Proliferation | | Necrosis | 3 | __________________________________________________________________________| Thymus | M M + + + + + + + M M + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + M M M + + + + + + M + M + + M + +| Galactocele | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 3 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Prepuce, Inflammation, Acute | 3 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 2 3 | __________________________________________________________________________| Skeletal Muscle | + | Hemorrhage | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Necrosis | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | | Metaplasia, Osseous | 1 2 | Mineralization | | Thrombosis | | Alveolar Epithelium, Hyperplasia | 3 2 1 | Alveolus, Edema | | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | Artery, Infiltration Cellular, | | Histiocyte | | Artery, Mediastinum, Inflammation | | Artery, Mediastinum, Mineralization | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Thrombosis | 2 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 | Lateral Wall, Metaplasia, Squamous | 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 2 2 1 1 1 1 1 2 2 1 1 1 1 1 2 2 2 1 1| Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | | Mineralization | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6| DAY ON TEST | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4| | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + | Cataract | | Hemorrhage | 2 | Cornea, Mineralization | | Retina, Atrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Infarct | | Mineralization | 2 | Nephropathy | 4 3 2 4 3 3 3 3 3 2 2 2 4 3 4 3 4 4 4 4 4 4| Thrombosis | 2 | Artery, Inflammation | | Papilla, Necrosis | 2 | Pelvis, Inflammation, Acute | 2 2 | Pelvis, Transitional Epithelium, | | Hyperplasia | 3 | Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation, Acute | 2 | Inflammation, Chronic Active | 1 | Transitional Epithelium, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Mineralization | | Parasite Metazoan | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Adenomatous | | Necrosis | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 1 2 | Basophilic Focus | X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | 2 1 2 2 3 3 | Degeneration, Fatty | 2 2 3 1 3 | Eosinophilic Focus | X | Fibrosis | | Hepatodiaphragmatic Nodule | X X| Inflammation, Granulomatous | 2 | Mineralization | 2 | Mixed Cell Focus | | Necrosis | 2 | Regeneration | 3 | Thrombosis | 2 | Bile Duct, Hyperplasia | 3 2 2 2 2 2 3 2 1 1 2 | Centrilobular, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + + + | Thrombosis | 4 | Artery, Inflammation, Chronic Active | 4 | Artery, Mineralization | 3 | Fat, Necrosis | 2 3 2 3 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 1 2 2 1 2 2 2 | Basophilic Focus | | Hyperplasia | 2 | Artery, Inflammation | 2 4 | Artery, Mineralization | 2 | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 3 | Inflammation, Acute | 3 | Mineralization | | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | Mineralization | 3 3 2 | Necrosis | | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + | Aorta, Mineralization | 2 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 2 3 2 3 3 3 3 2 2 2 3 3 2 3 2| Mineralization | | Artery, Mineralization | 2 3 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 2 2 1 2 2 2 2| Hypertrophy | 2 2 2 | Necrosis | 3 3 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 2 2 2 2 3 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 4 3 3 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Pars Distalis, Metaplasia, Osseous | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 2 1 2 1 1 1 1 1 1 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 4 | Inflammation, Suppurative | 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 1 | Artery, Inflammation, Chronic Active | 2 3 2| Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Lymph Node | + + + + + + | Iliac, Hemorrhage | 2 | Renal, Angiectasis | | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + M + + + + + + + + + + + M| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + +| Hemorrhage | 2 | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 3 2 | Hematopoietic Cell Proliferation | 1 | Necrosis | 2 | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + M M + + + + M + M M + M M +| Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 4 3 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Prepuce, Inflammation, Acute | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 2 | __________________________________________________________________________| Skeletal Muscle | + | Hemorrhage | 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2| Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Inflammation, Chronic Active | 1 1 | Metaplasia, Osseous | | Mineralization | 2 3 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 2 3 2 | Alveolus, Edema | 3 | Alveolus, Infiltration Cellular, | | Histiocyte | | Artery, Infiltration Cellular, | | Histiocyte | | Artery, Mediastinum, Inflammation | 3 | Artery, Mediastinum, Mineralization | 3 3 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Thrombosis | 2 3 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | | Lateral Wall, Metaplasia, Squamous | | Olfactory Epithelium, Degeneration, | | Hyaline | 1 2 1 2 1 2 2 2 2 1 2 2 1 2 1 2 1 1 2 2 2 2| Olfactory Epithelium, Metaplasia | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | 1 | Mineralization | 3 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6| DAY ON TEST | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4| | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 3 | Hemorrhage | | Cornea, Mineralization | 2 | Retina, Atrophy | 4 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Infarct | 3 | Mineralization | 3 4 | Nephropathy | 3 4 4 2 3 4 3 4 2 3 4 4 4 3 2 4 2 3 2 3 3 4| Thrombosis | | Artery, Inflammation | 3 | Papilla, Necrosis | | Pelvis, Inflammation, Acute | | Pelvis, Transitional Epithelium, | | Hyperplasia | | Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Acute | 3 | Inflammation, Chronic Active | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Inflammation, Chronic Active | | 1 3.0| Mineralization | 2 | 1 2.0| Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Inflammation, Chronic Active | | 1 2.0| Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 50 | Hyperplasia, Adenomatous | | 1 3.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 50 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Angiectasis | | 4 1.8| Basophilic Focus | X | 14 | Clear Cell Focus | | 2 | Degeneration, Cystic | 2 | 13 2.0| Degeneration, Fatty | | 9 2.2| Eosinophilic Focus | | 1 | Fibrosis | | 1 2.0| Hepatodiaphragmatic Nodule | | 3 | Inflammation, Granulomatous | 2 | 2 2.0| Mineralization | | 1 2.0| Mixed Cell Focus | | 2 | Necrosis | | 2 2.0| Regeneration | | 2 2.5| Thrombosis | | 1 2.0| Bile Duct, Hyperplasia | 1 2 2 3 2 | 29 1.9| Centrilobular, Necrosis | | 3 1.7| __________________________________________________________________________|____________| Mesentery | + + + | 12 | Thrombosis | | 1 4.0| Artery, Inflammation, Chronic Active | | 1 4.0| Artery, Mineralization | 4 | 3 3.3| Fat, Necrosis | 2 | 7 2.3| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Atrophy | 1 3 | 22 1.9| Basophilic Focus | | 1 | Hyperplasia | | 2 2.0| Artery, Inflammation | 4 | 3 3.3| Artery, Mineralization | 3 | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Hyperplasia, Squamous | | 4 2.5| Inflammation, Acute | | 3 3.0| Mineralization | 4 | 2 3.0| Necrosis | | 4 3.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Inflammation, Acute | | 1 2.0| Mineralization | 3 | 6 2.3| Necrosis | | 2 2.5| __________________________________________________________________________|____________| Tooth | + | 2 | Developmental Malformation | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 4 | Aorta, Mineralization | 3 | 4 3.0| __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 2 4 1 2 | 39 2.2| Mineralization | 3 | 1 3.0| Artery, Mineralization | 3 | 3 2.7| Atrium, Thrombosis | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Hyperplasia | 2 1 2 1 2 | 24 1.7| Hypertrophy | | 6 2.3| Necrosis | | 2 3.0| Vacuolization Cytoplasmic | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Hyperplasia | 3 1 2 | 24 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + | 49 | Hyperplasia | | 10 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Cyst | | 1 3.0| Pars Distalis, Metaplasia, Osseous | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + M + + + + | 49 | C-Cell, Hyperplasia | 1 1 1 2 | 29 1.1| Follicular Cell, Hyperplasia | | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Granuloma Sperm | | 1 3.0| __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 49 | Inflammation, Chronic Active | | 4 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + | 49 | Hyperplasia | | 1 1.0| Inflammation, Chronic Active | | 7 3.1| Inflammation, Suppurative | | 2 2.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Atrophy | 3 2 | 10 2.8| Artery, Inflammation, Chronic Active | | 7 2.0| Interstitial Cell, Hyperplasia | 1 | 13 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Atrophy | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + | 18 | Iliac, Hemorrhage | | 1 2.0| Renal, Angiectasis | | 1 4.0| Renal, Hemorrhage | 2 | 6 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + | 43 | Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 46 | Hemorrhage | | 1 2.0| Infiltration Cellular, Plasma Cell | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 46 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibrosis | 2 | 12 2.5| Hematopoietic Cell Proliferation | 2 | 2 1.5| Necrosis | | 2 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + | 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + M | 33 | Galactocele | | 2 2.5| __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Hyperkeratosis | | 3 3.3| Inflammation, Chronic Active | | 2 2.0| Prepuce, Inflammation, Acute | | 3 2.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Fibrous Osteodystrophy | 3 | 7 2.3| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Hemorrhage | | 2 2.0| Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | Inflammation, Acute | 2 | 1 2.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Hemorrhage | 1 | 2 1.0| Inflammation, Chronic Active | | 2 1.0| Metaplasia, Osseous | | 2 1.5| Mineralization | 3 | 3 2.7| Thrombosis | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | | 6 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Edema | | 1 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Artery, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| Artery, Mediastinum, Inflammation | | 1 3.0| Artery, Mediastinum, Mineralization | 3 | 5 3.0| __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Inflammation, Suppurative | 2 | 3 1.7| Thrombosis | 3 3 2 | 8 2.3| Goblet Cell, Lateral Wall, | | | Hyperplasia | | 1 2.0| Lateral Wall, Metaplasia, Squamous | 1 | 2 1.5| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 2 1 2 | 50 1.5| Olfactory Epithelium, Metaplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | Metaplasia, Squamous | | 1 1.0| Mineralization | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | Cataract | | 2 3.0| Hemorrhage | | 1 2.0| Cornea, Mineralization | | 1 2.0| Retina, Atrophy | | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | | 1 3.0| Infarct | | 1 3.0| Mineralization | 4 | 4 3.3| Nephropathy | 4 4 2 1 3 | 49 3.2| Thrombosis | | 1 2.0| Artery, Inflammation | | 1 3.0| Papilla, Necrosis | | 1 2.0| Pelvis, Inflammation, Acute | | 2 2.0| Pelvis, Transitional Epithelium, | | | Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 5| 2| 5| | | DAY ON TEST | 9| 7| 0| 3| 4| 8| | | | 5| 6| 1| 7| 7| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Hemorrhage | | 1 2.0| Inflammation, Acute | | 2 2.5| Inflammation, Chronic Active | | 1 1.0| Transitional Epithelium, Hyperplasia | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X | Clear Cell Focus | X X | Degeneration, Cystic | 2 2 2 2 1 2 3 | Degeneration, Fatty | 2 | Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | | Necrosis | 2 2 | Bile Duct, Hyperplasia | 1 2 1 1 2 2 3 1 2 2 2 3 1 3 2 2 2 1 2| Centrilobular, Necrosis | 2 3 1| __________________________________________________________________________| Mesentery | + + + + | Artery, Mineralization | 3 2 | Fat, Necrosis | 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 2 2 4 3 2 2 3 2 2 2| Hyperplasia | 2 2 | Thrombosis | 4 | Artery, Inflammation | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 4 3 | Inflammation, Acute | | Mineralization | 4 2 1 2 | Necrosis | 4 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | 4 3 3 1 | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Necrosis | 3 3 | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + | Aorta, Mineralization | 4 3 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 3 2 3 1 2 1 2 2 2 2 3 2 2 1 2 2 | Mineralization | 4 2 | Thrombosis | 2 1 | Artery, Mineralization | 3 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Hyperplasia | 2 1 3 1 2 2 2 | Hypertrophy | 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 3 2 2 2 3 2 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 2 2 3 4 2 4 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 | Pars Distalis, Hyperplasia | 2 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 1 2 2 1 1 2 2 2| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 3 3 3 | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 | Artery, Inflammation, Chronic Active | 2 2 3 3 | Interstitial Cell, Hyperplasia | 1 2 1 1 1 2 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + M M + M + + + + + + M M + + + + + + + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Plasma Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 3 2 3 3 | Hematopoietic Cell Proliferation | | Necrosis | 3 3 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M M M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + M + M + + + M + M M + M + M + M M +| Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 4 3 | Inflammation, Chronic Active | 4 2 4 3 3 4 | Prepuce, Inflammation, Acute | 3 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 3 4 4 1 | Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 4 | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6| DAY ON TEST | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1| | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Inflammation, Suppurative | 4 | Metaplasia, Osseous | | Mineralization | 4 2 3 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia | 1 1 1 1 1 | Artery, Mediastinum, Mineralization | 4 2 4 | Interstitium, Fibrosis | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 2 1 1 1 1 | Thrombosis | 2 2 4 1 3 4 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1 2 | Lateral Wall, Hyperplasia | 3 2 1 3 | Lateral Wall, Metaplasia, Squamous | 3 1 2 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 1 2 1 2 2 2 1 2 2 2 2 2 2 2 3 1 1 2 2 1 2| Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Degeneration | 3 | __________________________________________________________________________| Zymbal's Gland | + | Hyperplasia, Squamous | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Infarct | 2 3 | Mineralization | 4 2 2 | Nephropathy | 4 4 4 4 4 2 2 4 2 3 4 2 2 2 3 4 4 4 3 4 4 3 2| Pelvis, Inflammation, Acute | 2 | Renal Tubule, Hyperplasia | 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + | Mineralization | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + | Mineralization | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + | Necrosis | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + | Angiectasis | 2 | Basophilic Focus | X X X X X X X X X | Clear Cell Focus | | Degeneration, Cystic | 3 1 2 1 3 2 1 | Degeneration, Fatty | 3 1 1 3 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Necrosis | 1 | Bile Duct, Hyperplasia | 2 1 2 1 2 2 2 1 3 2 2 | Centrilobular, Necrosis | 1 2 | __________________________________________________________________________| Mesentery | + | Artery, Mineralization | | Fat, Necrosis | | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + | Atrophy | 3 2 1 2 2 1 1 3 2 | Hyperplasia | 2 2 | Thrombosis | | Artery, Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Squamous | | Inflammation, Acute | 2 | Mineralization | 2 | Necrosis | 4 3 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | 1 | Mineralization | 1 2 3 | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Necrosis | 2 2 | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Cardiomyopathy | 1 2 2 3 2 1 2 2 2 3 2 1 2 1 2 3 3 | Mineralization | | Thrombosis | | Artery, Mineralization | 3 | Atrium, Thrombosis | 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + | Accessory Adrenal Cortical Nodule | | Hyperplasia | 2 1 2 2 2 3 1 2 1 | Hypertrophy | 2 2 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 1 2 2 3 4 1 2 2 2 3 2 3 1 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + | Hyperplasia | 2 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + | Mineralization | 4 | Pars Distalis, Hyperplasia | 2 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + | C-Cell, Hyperplasia | 1 2 1 1 1 2 2 2 1 2 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + | Granuloma Sperm | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 3 4 | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + | Mineralization | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + | Atrophy | 3 3 | Artery, Inflammation, Chronic Active | 2 2 | Interstitial Cell, Hyperplasia | 1 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + M + + + M + + + + + + + + + M | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + M + + + + + + + + M | Hemorrhage | 2 | Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + | Ectasia | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + M + + + + | Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + | Fibrosis | 3 4 2 | Hematopoietic Cell Proliferation | 1 | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + M + M + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + M M + M + + + + M M + + M M + + + + | Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + | Hyperkeratosis | 2 | Inflammation, Chronic Active | 3 2 | Prepuce, Inflammation, Acute | 1 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + | Fibrous Osteodystrophy | 1 2 1 | Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + | Epiglottis, Metaplasia, Squamous | 1 | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6| DAY ON TEST | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0| | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0.12 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 1 | Inflammation, Suppurative | | Metaplasia, Osseous | 2 | Mineralization | 3 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 3 3 2 | Alveolar Epithelium, Metaplasia | 1 1 | Artery, Mediastinum, Mineralization | | Interstitium, Fibrosis | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Suppurative | 2 2 1 3 | Thrombosis | 3 2 3 2 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 | Lateral Wall, Hyperplasia | 2 2 2 3 | Lateral Wall, Metaplasia, Squamous | 2 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 1 2 1 2 1 1 1 2 2 2 2 2 2 2 1 2 1 1 2 | Olfactory Epithelium, Metaplasia | 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | | Mineralization | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Degeneration | | __________________________________________________________________________| Zymbal's Gland | | Hyperplasia, Squamous | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + | Cyst | | Infarct | | Mineralization | 2 4 | Nephropathy | 4 2 3 4 4 3 4 4 3 3 4 3 3 3 4 2 3 2 4 4 | Pelvis, Inflammation, Acute | 2 2 | Renal Tubule, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 2 2 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Mineralization | | 1 3.0| Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | Mineralization | | 1 1.0| Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 50 | Parasite Metazoan | X | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | Necrosis | 3 3 | 3 2.7| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 50 | Inflammation, Acute | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + | 50 | Angiectasis | | 1 2.0| Basophilic Focus | X X | 18 | Clear Cell Focus | | 2 | Degeneration, Cystic | 2 2 | 16 1.9| Degeneration, Fatty | | 5 2.0| Eosinophilic Focus | | 4 | Hepatodiaphragmatic Nodule | | 5 | Mixed Cell Focus | | 1 | Necrosis | | 3 1.7| Bile Duct, Hyperplasia | 2 1 1 1 | 34 1.8| Centrilobular, Necrosis | 2 | 6 1.8| __________________________________________________________________________|____________| Mesentery | + | 6 | Artery, Mineralization | | 2 2.5| Fat, Necrosis | 3 | 4 2.3| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Atrophy | 2 | 23 2.1| Hyperplasia | | 4 2.0| Thrombosis | | 1 4.0| Artery, Inflammation | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Hyperplasia, Squamous | | 2 3.5| Inflammation, Acute | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | | 5 2.2| Necrosis | 2 | 7 2.9| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Inflammation, Acute | | 1 1.0| Mineralization | | 7 2.4| Necrosis | | 4 2.5| __________________________________________________________________________|____________| Tooth | | 2 | Developmental Malformation | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 4 | Aorta, Mineralization | | 4 3.5| __________________________________________________________________________|____________| Heart | + + + + + | 50 | Cardiomyopathy | 2 1 2 | 37 2.0| Mineralization | | 2 3.0| Thrombosis | | 2 1.5| Artery, Mineralization | | 2 3.0| Atrium, Thrombosis | 3 | 3 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Accessory Adrenal Cortical Nodule | | 1 2.0| Hyperplasia | 1 2 1 3 | 20 1.8| Hypertrophy | | 7 1.4| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Hyperplasia | 2 2 | 29 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 49 | Hyperplasia | | 10 2.9| __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 50 | Mineralization | | 2 3.5| Pars Distalis, Hyperplasia | 3 | 3 2.3| Pars Intermedia, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | C-Cell, Hyperplasia | 1 4 1 | 25 1.6| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + | 50 | Granuloma Sperm | | 1 3.0| __________________________________________________________________________|____________| Penis | | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 50 | Inflammation, Chronic Active | | 2 3.5| __________________________________________________________________________|____________| Prostate | + + + + + | 50 | Inflammation, Chronic Active | | 7 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 50 | Mineralization | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + | 50 | Atrophy | | 4 3.0| Artery, Inflammation, Chronic Active | 1 2 | 8 2.1| Interstitial Cell, Hyperplasia | 1 1 | 13 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | Renal, Hemorrhage | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M | 38 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 46 | Hemorrhage | | 1 2.0| Infiltration Cellular, Plasma Cell | | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 49 | Ectasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 47 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Fibrosis | 2 3 | 11 2.8| Hematopoietic Cell Proliferation | 3 | 2 2.0| Necrosis | 2 | 5 2.6| __________________________________________________________________________|____________| Thymus | + + + + M | 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M M | 29 | Galactocele | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | | 3 3.0| Inflammation, Chronic Active | | 8 3.1| Prepuce, Inflammation, Acute | | 4 2.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Fibrous Osteodystrophy | | 8 2.5| Hyperostosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Epiglottis, Metaplasia, Squamous | | 2 2.5| __________________________________________________________________________|____________| Lung | + + + + + | 50 | Hemorrhage | | 2 1.0| Inflammation, Suppurative | | 1 4.0| Metaplasia, Osseous | | 1 2.0| Mineralization | | 4 3.0| Thrombosis | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | 3 | 6 2.2| Alveolar Epithelium, Metaplasia | 1 1 | 9 1.0| Artery, Mediastinum, Mineralization | | 3 3.3| Interstitium, Fibrosis | | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + | 50 | Inflammation, Suppurative | | 10 1.7| Thrombosis | 2 3 | 13 2.6| Goblet Cell, Lateral Wall, | | | Hyperplasia | | 4 1.5| Lateral Wall, Hyperplasia | | 8 2.3| Lateral Wall, Metaplasia, Squamous | | 6 1.8| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 1 1 1 | 50 1.6| Olfactory Epithelium, Metaplasia | | 2 1.0| __________________________________________________________________________|____________| Trachea | + + + + + | 50 | Inflammation, Acute | | 1 3.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 4| 6| 6| 6| 7| 6| | | DAY ON TEST | 8| 7| 9| 0| 3| 0| | | | 0| 8| 8| 5| 4| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 0.12 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Degeneration | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Hyperplasia, Squamous | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Cyst | | 1 2.0| Infarct | | 2 2.5| Mineralization | | 5 2.8| Nephropathy | 2 4 3 2 4 | 48 3.2| Pelvis, Inflammation, Acute | | 3 2.0| Renal Tubule, Hyperplasia | | 3 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Inflammation, Chronic Active | | 3 2.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X| Clear Cell Focus | | Degeneration, Cystic | 2 1 2 2 3 4 1 2 2 2 2| Degeneration, Fatty | 2 2 1 | Eosinophilic Focus | | Hepatodiaphragmatic Nodule | | Mixed Cell Focus | X X X | Necrosis | 2 | Thrombosis | | Bile Duct, Hyperplasia | 2 2 3 2 1 1 1 1 2 2 2 3 2 1 3 3 1| Centrilobular, Necrosis | 3 2 | __________________________________________________________________________| Mesentery | + + + + + +| Artery, Inflammation, Chronic Active | | Artery, Mineralization | 2 | Fat, Necrosis | 3 2 2 2 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 3 1 2 2 1 3 3 2 2 2 1 2 1 | Basophilic Focus | X X | Hyperplasia | | Artery, Inflammation | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X | Hyperplasia, Squamous | 2 | Inflammation, Acute | | Mineralization | | Necrosis | 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Mineralization | 4 | Necrosis | 1 | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 4 2 2 1 2 4 3 2 2 2 2 2 2 2 2 1 3 3| Artery, Mineralization | 3 | Atrium, Thrombosis | 2 1 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 2 1 3 2 1 2 2| Hypertrophy | 2 2 | Necrosis | 4 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 3 2 3 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 4 3 2| __________________________________________________________________________| Pituitary Gland | + + + + I + + + + + + + + + + + + + + + +| Mineralization | | Pars Distalis, Hyperplasia | 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 2 1 2 1 1 2 2 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 3 3 3 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 1 4 | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Artery, Inflammation, Chronic Active | 2 3| Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + +| Renal, Hemorrhage | 2 3 2| Renal, Inflammation, Granulomatous | 3 | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + + + + + + + + M + + M M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 1 3 3 2| Hematopoietic Cell Proliferation | 1| Hemorrhage | | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M + M M M M M M + + M + + M M M + + +| Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 4| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 3 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 1 1 1 2 1 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | | Metaplasia, Osseous | | Mineralization | 3 | Alveolar Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7| DAY ON TEST | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3| | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Metaplasia | 2 1 2 2 3 2 3 1 1 3 2 2 3 2 3 1 2 2 2 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 2 1 1 1 1 1 1 2 1 1 1| Artery, Mediastinum, Mineralization | 3 | Interstitium, Fibrosis | 1 1 1 2 1 2 1 2 1 2 1 2 1 2 1 1 1 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 1 1 2 1 3 1| Thrombosis | 3 2 2 2 3 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 1 1 3 2 1 2 2 2 2 1 2 2 2 3 2 1 2| Lateral Wall, Hyperplasia | 1 3 2 2 1 3 2 3 2 2 2 3 2 2 2 3 3 2 1 2 2| Lateral Wall, Metaplasia, Squamous | 4 2 2 2 1 2 2 2 1 3 2 1 2 1 3 2| Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 2 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1 2| Olfactory Epithelium, Metaplasia | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 2 | Cornea, Inflammation, Chronic Active | 2 | Retina, Atrophy | 3 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Cyst | 3 | Mineralization | 3 | Nephropathy | 3 2 2 4 2 3 4 4 3 3 4 2 4 4 4 4 4 4 2 4 4| Thrombosis | 2| Artery, Inflammation | | Pelvis, Inflammation, Acute | 1 | Renal Tubule, Hyperplasia | 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 2 | Basophilic Focus | X X X X X| Clear Cell Focus | X | Degeneration, Cystic | 2 2 3 1 3 | Degeneration, Fatty | 1 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Necrosis | | Thrombosis | 3 | Bile Duct, Hyperplasia | 3 3 1 1 2 2 2 1 3 2 2 3 2 1 3 3 2| Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + +| Artery, Inflammation, Chronic Active | | Artery, Mineralization | | Fat, Necrosis | 2 2 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 2 1 2 2 1 1 3 1 2 2 2 1| Basophilic Focus | X | Hyperplasia | 2 4 1| Artery, Inflammation | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | X| Hyperplasia, Squamous | | Inflammation, Acute | 2 | Mineralization | 2 | Necrosis | 2 2 2 4 1 4 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 3 1 1 1 3 | Necrosis | 2 4 | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 1 2 2 2 2 1 1 1 1 1 3 1 2 2 2| Artery, Mineralization | | Atrium, Thrombosis | 4 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 1 1 2 2 3 1 2 2 | Hypertrophy | 2 2 2 2 2 | Necrosis | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 2 2 2 3 4 2 2 2 3 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + +| Hyperplasia | 2 1 2 3 2 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Pars Distalis, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 3 1| Follicular Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 2 3 | _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Artery, Inflammation, Chronic Active | 3 | Interstitial Cell, Hyperplasia | 1 1 2 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + | Renal, Hemorrhage | 2 2 2 | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + + M + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + M| Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 3 2 3 3 3 | Hematopoietic Cell Proliferation | | Hemorrhage | 3 | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + M + + M + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M + + + M M M M + + + + + M M + M M| Galactocele | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 1 2 2 | __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 2 1 1 1 1 1 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | 3 | Metaplasia, Osseous | 1 | Mineralization | | Alveolar Epithelium, Hyperplasia | 1 2 | _____________________________________________________________________________________________________________________| Page 83 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4| DAY ON TEST | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4| | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Metaplasia | 2 2 2 2 2 1 2 2 2 2 2 2 1 2 1 2 2 2 2 2 1| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 2 1 1 1 1 1 1 1 2 2 | Artery, Mediastinum, Mineralization | | Interstitium, Fibrosis | 1 1 2 1 2 2 1 2 1 2 2 1 1 2 1 1 2 2 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 4 2 1 | Thrombosis | 1 1 1 1 2 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1 2 1 2 1 1 1 1 1| Lateral Wall, Hyperplasia | 2 2 2 1 1 1 2 1 2 3 2 2 2 3 1 2 2 3 2 3 1 2 2 1| Lateral Wall, Metaplasia, Squamous | 2 1 2 1 2 2 1 2 1 2 1 1 2 1 2 2 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 2 2 1 1 1 1 1 2 2 2 3 2 1 2 1 2 2 3 2 1 2 3| Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | Cornea, Inflammation, Chronic Active | | Retina, Atrophy | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 2 | Mineralization | | Nephropathy | 4 3 2 4 4 2 1 4 4 2 2 3 2 3 3 4 4 4 4 2 2 4 2 2| Thrombosis | | Artery, Inflammation | 2 | Pelvis, Inflammation, Acute | 3 2 | Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Parasite Metazoan | X | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 49 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Angiectasis | | 2 3.0| Basophilic Focus | X | 11 | Clear Cell Focus | | 1 | Degeneration, Cystic | 3 1 1 | 19 2.1| Degeneration, Fatty | | 5 1.6| Eosinophilic Focus | X | 2 | Hepatodiaphragmatic Nodule | | 2 | Mixed Cell Focus | | 4 | Necrosis | | 1 2.0| Thrombosis | | 1 3.0| Bile Duct, Hyperplasia | 2 3 2 | 37 2.0| Centrilobular, Necrosis | | 3 2.3| __________________________________________________________________________|____________| Mesentery | + + | 12 | Artery, Inflammation, Chronic Active | 3 | 1 3.0| Artery, Mineralization | | 1 2.0| Fat, Necrosis | 3 | 9 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Atrophy | 2 | 30 1.9| Basophilic Focus | X | 4 | Hyperplasia | 2 | 4 2.3| Artery, Inflammation | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Diverticulum | | 2 | Hyperplasia, Squamous | | 1 2.0| Inflammation, Acute | | 1 2.0| Mineralization | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | | 9 2.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Mineralization | | 7 2.1| Necrosis | | 3 2.3| __________________________________________________________________________|____________| Tooth | | 1 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Mineralization | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + | 50 | Cardiomyopathy | 2 3 2 3 2 | 44 2.0| Artery, Mineralization | | 1 3.0| Atrium, Thrombosis | | 5 2.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Hyperplasia | | 23 1.8| Hypertrophy | | 7 2.0| Necrosis | | 2 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Hyperplasia | 2 3 | 24 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 48 | Hyperplasia | 2 3 | 15 2.4| __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 49 | Mineralization | 2 | 1 2.0| Pars Distalis, Hyperplasia | | 3 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | C-Cell, Hyperplasia | 2 | 31 1.3| Follicular Cell, Hyperplasia | | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + | 50 | Granuloma Sperm | 2 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 50 | Cyst | 4 | 1 4.0| Inflammation, Chronic Active | | 3 3.0| __________________________________________________________________________|____________| Prostate | + + + + + | 50 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 4 | 5 3.2| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 50 | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + | 50 | Atrophy | | 6 3.0| Artery, Inflammation, Chronic Active | 3 | 4 2.8| Interstitial Cell, Hyperplasia | 1 | 13 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + | 24 | Renal, Hemorrhage | | 6 2.2| Renal, Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + | 44 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 46 | Infiltration Cellular, Plasma Cell | | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 48 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Fibrosis | 3 2 | 16 2.4| Hematopoietic Cell Proliferation | | 1 1.0| Hemorrhage | | 1 3.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | M + + + + | 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M | 28 | Galactocele | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + | 50 | Hyperkeratosis | | 1 4.0| Inflammation, Chronic Active | | 2 3.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 87 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Fibrous Osteodystrophy | 3 2 | 8 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Epiglottis, Metaplasia, Squamous | 1 2 | 16 1.3| __________________________________________________________________________|____________| Lung | + + + + + | 50 | Congestion, Chronic | | 1 3.0| Metaplasia, Osseous | | 1 1.0| Mineralization | | 1 3.0| Alveolar Epithelium, Hyperplasia | | 3 1.7| Alveolar Epithelium, Metaplasia | 2 2 2 2 | 46 1.9| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 1 | 27 1.2| Artery, Mediastinum, Mineralization | | 1 3.0| Interstitium, Fibrosis | 1 1 1 | 40 1.4| __________________________________________________________________________|____________| Nose | + + + + + | 50 | Inflammation, Suppurative | 3 | 12 1.8| Thrombosis | | 12 1.9| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 2 1 2 | 41 1.5| Lateral Wall, Hyperplasia | 2 2 2 2 1 | 50 2.0| Lateral Wall, Metaplasia, Squamous | 2 2 1 | 36 1.8| Olfactory Epithelium, Degeneration, | | | Hyaline | 1 1 2 2 1 | 50 1.6| Olfactory Epithelium, Metaplasia | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + | 50 | Inflammation, Acute | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 2 2.5| Cornea, Inflammation, Chronic Active | | 1 2.0| Retina, Atrophy | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 88 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 6| 4| 6| | | DAY ON TEST | 7| 9| 3| 4| 3| 0| | | | 1| 7| 4| 9| 3| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Angiectasis | | 1 3.0| Cyst | 3 | 3 2.7| Mineralization | | 1 3.0| Nephropathy | 2 4 3 4 4 | 50 3.2| Thrombosis | | 1 2.0| Artery, Inflammation | | 1 2.0| Pelvis, Inflammation, Acute | 3 | 4 2.3| Renal Tubule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Inflammation, Chronic Active | 2 | 4 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 89 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 | Basophilic Focus | X X X X X X X X | Clear Cell Focus | | Degeneration, Cystic | 1 2 2 2 1 2| Degeneration, Fatty | 1 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Regeneration | | Bile Duct, Hyperplasia | 1 2 1 3 3 2 1 2 2 3 2 2 2| Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + + + + + +| Artery, Mineralization | 3 | Fat, Necrosis | 2 3 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 3 1 2 3 2 3 3 3 2 2 | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | X | Hyperplasia, Squamous | 3 3 | Inflammation, Acute | 3 3 | Mineralization | 3 | Necrosis | 3 4 2 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Acute | 3 | Mineralization | 1 3 1 | Necrosis | 1 | __________________________________________________________________________| Tooth | + | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 2 2 1 3 1 3 2 1 3 2 1 1 2 2 1| Artery, Mineralization | | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 2 2 2 2 2 2 1 2 1| Hypertrophy | 2 2 2 2 | Necrosis | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 3 2 1 2 2 1 2 3 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 4 3 2 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hemorrhage | 4 | Pars Distalis, Hyperplasia | 3 4 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 1 1 1 2 1 1 | Follicular Cell, Hyperplasia | 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 4 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 4 3 3| Artery, Inflammation, Chronic Active | 2 2 | Interstitial Cell, Hyperplasia | 2 1 1 1 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + | Renal, Hemorrhage | | __________________________________________________________________________| Lymph Node, Bronchial | M + M M + M + + M + + + M + + + + + M + + M M +| Fibrosis | | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + + M| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 2 2 2 2 1 | Hyperplasia, Focal | | Necrosis | | __________________________________________________________________________| Thymus | M + + + + + + M + M + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + M M M + M + + + + M + + + M M +| Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 1 | Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Epiglottis, Metaplasia, Squamous | 3 2 4 3 1 3 3 1 2 1 1 1 3 4 2 2 4 2 4 1 2| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Mineralization | 3 | Alveolar Epithelium, Hyperplasia | 2 2 3 | Alveolar Epithelium, Metaplasia | 3 3 2 3 4 3 3 3 3 3 3 3 2 3 4 3 2 2 3 2 3 4 3 3| Alveolus, Edema | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 1 2| Artery, Mediastinum, Mineralization | 3 | Bronchiole, Necrosis | 1 | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5| DAY ON TEST | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8| | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Fibrosis | 2 2 2 3 2 2 3 2 2 2 2 2 3 3 2 2 3 1 3 3 2 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 3 2 2 3 3 1 2 2 | Thrombosis | 1 3 2 2| Goblet Cell, Lateral Wall, | | Hyperplasia | 2 3 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 3 2| Lateral Wall, Hyperplasia | 2 3 2 3 2 3 3 3 2 3 3 2 2 3 3 3 2 3 3 2 3 3 2 3| Lateral Wall, Metaplasia, Squamous | 3 1 2 3 4 4 1 1 1 2 2 2 4 3 2 2 3 1 2 3 1 1| Olfactory Epithelium, Degeneration, | | Hyaline | 2 3 2 2 2 3 2 2 3 3 3 4 2 2 1 2 2 2 2 3 3 3 3 2| Olfactory Epithelium, Metaplasia | 4 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Squamous | | Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 | Infarct | | Mineralization | 2 | Nephropathy | 3 4 2 4 4 4 4 3 2 4 3 4 3 4 4 4 2 4 4 3 4 4 2 2| Pelvis, Inflammation, Acute | 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Transitional Epithelium, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + | Necrosis | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Angiectasis | 2 | Basophilic Focus | X | Clear Cell Focus | X | Degeneration, Cystic | 2 1 2 3 1 2 | Degeneration, Fatty | 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | | Regeneration | 2 2 | Bile Duct, Hyperplasia | 3 2 3 2 1 2 1 2 3 2 2 2 2 2 1 2 | Centrilobular, Necrosis | 3 | __________________________________________________________________________| Mesentery | + | Artery, Mineralization | | Fat, Necrosis | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | Atrophy | 2 1 1 3 1 2 2 2 3 2 1 | Hyperplasia | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | Foreign Body | | Hyperplasia, Squamous | 3 | Inflammation, Acute | | Mineralization | 2 2 | Necrosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | Cyst | 3 | Inflammation, Acute | | Mineralization | 2 1 2 1 2 | Necrosis | 2 3 | __________________________________________________________________________| Tooth | + | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 94 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | Cardiomyopathy | 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 | Artery, Mineralization | | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 2 1 2 | Hypertrophy | 2 4 1 | Necrosis | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 2 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | M + + + + + + M + + + + + + + + + + + + | Hyperplasia | 3 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + I + + + + + + + + + + + + | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | C-Cell, Hyperplasia | 1 3 1 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | Granuloma Sperm | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + M + + + + + + + + | Inflammation, Chronic Active | 3 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + | Hyperplasia | | Inflammation, Chronic Active | 2 4 3 3 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | Atrophy | | Artery, Inflammation, Chronic Active | | Interstitial Cell, Hyperplasia | 1 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 95 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + | Renal, Hemorrhage | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + | Fibrosis | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + M + + M + + + + + + + + | Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + M + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | Fibrosis | 2 2 2 3 3 | Hyperplasia, Focal | 3 | Necrosis | 4 | __________________________________________________________________________| Thymus | M + M M + + M + + + + + + + M + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + M + + + M + M + + M M + + + M M | Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | Fibrous Osteodystrophy | 3 | Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + | Mineralization | | Epiglottis, Metaplasia, Squamous | 2 2 3 1 3 3 1 3 2 4 3 3 1 3 1 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | | Mineralization | | Alveolar Epithelium, Hyperplasia | 2 | Alveolar Epithelium, Metaplasia | 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 3 3 3 | Alveolus, Edema | | Alveolus, Infiltration Cellular, | | Histiocyte | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 | Artery, Mediastinum, Mineralization | | Bronchiole, Necrosis | | _____________________________________________________________________________________________________________________| Page 96 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 _____________________________________________________________________________________________________________________ | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6| DAY ON TEST | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0| | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Fibrosis | 2 2 2 3 3 2 2 1 3 2 2 2 2 2 2 2 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | Inflammation, Suppurative | 1 2 1 1 2 2 1 3 | Thrombosis | 4 2 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 2 2 2 3 2 3 3 1 2 1 2 1 2 3 3 3 2 2 | Lateral Wall, Hyperplasia | 3 2 2 3 3 3 3 2 3 3 3 3 2 3 3 3 3 2 3 | Lateral Wall, Metaplasia, Squamous | 1 1 3 1 1 4 3 2 1 3 4 3 2 2 2 2 3 2 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 4 4 3 2 3 3 3 2 1 3 2 4 2 3 1 1 3 1 2 1 | Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | Metaplasia, Squamous | | Mineralization | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Cyst | | Infarct | 3 | Mineralization | | Nephropathy | 2 3 2 3 2 4 4 2 3 3 2 3 3 3 4 3 3 3 2 2 | Pelvis, Inflammation, Acute | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 1 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 97 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Parasite Metazoan | X | 6 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 49 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Parasite Metazoan | | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 49 | Necrosis | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 48 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Angiectasis | | 4 1.5| Basophilic Focus | | 9 | Clear Cell Focus | | 1 | Degeneration, Cystic | 3 3 | 14 1.9| Degeneration, Fatty | 2 | 4 1.8| Eosinophilic Focus | | 2 | Hepatodiaphragmatic Nodule | | 4 | Mixed Cell Focus | | 1 | Regeneration | | 2 2.0| Bile Duct, Hyperplasia | 2 1 1 2 | 33 1.9| Centrilobular, Necrosis | | 2 2.5| __________________________________________________________________________|____________| Mesentery | | 8 | Artery, Mineralization | | 1 3.0| Fat, Necrosis | | 5 2.6| __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Atrophy | 2 3 2 | 26 2.2| Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Foreign Body | | 1 | Hyperplasia, Squamous | | 3 3.0| Inflammation, Acute | | 2 3.0| Mineralization | 1 | 4 2.0| Necrosis | 3 | 7 2.9| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Cyst | | 1 3.0| Inflammation, Acute | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | 4 1 | 10 1.8| Necrosis | | 3 2.0| __________________________________________________________________________|____________| Tooth | | 2 | Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Aorta, Mineralization | 4 | 2 3.5| __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 3 2 1 | 36 1.8| Artery, Mineralization | 4 | 1 4.0| Atrium, Thrombosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Hyperplasia | 2 2 | 18 1.7| Hypertrophy | | 7 2.1| Necrosis | | 2 2.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Hyperplasia | 2 | 17 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 47 | Hyperplasia | 4 1 | 11 2.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 49 | Pars Distalis, Hemorrhage | | 1 4.0| Pars Distalis, Hyperplasia | 2 3 | 5 2.6| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Hyperplasia | 2 2 2 | 16 1.4| Follicular Cell, Hyperplasia | | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Granuloma Sperm | 2 | 2 2.5| __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 49 | Inflammation, Chronic Active | | 6 2.7| __________________________________________________________________________|____________| Prostate | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | | 6 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Atrophy | 4 | 6 3.2| Artery, Inflammation, Chronic Active | 3 | 3 2.3| Interstitial Cell, Hyperplasia | | 9 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + + | 10 | Renal, Hemorrhage | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M | 38 | Fibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M M + + + + | 42 | Infiltration Cellular, Plasma Cell | | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 46 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibrosis | 2 | 14 2.1| Hyperplasia, Focal | | 1 3.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + | 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M M M | 30 | Galactocele | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Fibrous Osteodystrophy | 4 | 4 3.0| Hyperostosis | 4 | 1 4.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Necrosis | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 100 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 50 | Mineralization | | 1 2.0| Epiglottis, Metaplasia, Squamous | 4 2 2 1 1 2 | 43 2.3| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Inflammation, Chronic Active | | 1 3.0| Mineralization | 4 | 2 3.5| Alveolar Epithelium, Hyperplasia | | 4 2.3| Alveolar Epithelium, Metaplasia | 3 3 2 3 3 | 47 2.9| Alveolus, Edema | | 1 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 1 2 1 | 42 1.9| Artery, Mediastinum, Mineralization | 3 | 2 3.0| Bronchiole, Necrosis | | 1 1.0| Interstitium, Fibrosis | 2 2 2 2 2 | 44 2.2| __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Inflammation, Suppurative | 2 3 1 | 20 1.9| Thrombosis | 4 | 8 2.6| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 1 2 3 3 2 | 48 2.1| Lateral Wall, Hyperplasia | 3 3 3 3 3 3 | 49 2.7| Lateral Wall, Metaplasia, Squamous | 4 3 3 2 2 | 46 2.3| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 3 1 4 1 3 | 50 2.4| Olfactory Epithelium, Metaplasia | | 1 4.0| __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | Metaplasia, Squamous | 2 | 1 2.0| Mineralization | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | 2 | 3 2.3| Infarct | | 1 3.0| Mineralization | 3 | 2 2.5| Nephropathy | 4 4 3 3 2 2 | 50 3.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 101 NTP Experiment-Test: 88034-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:31:33 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 5| 6| | | DAY ON TEST | 2| 3| 4| 9| 5| 6| | | | 3| 3| 4| 0| 9| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 6| 6| 6| 6| 6| 6| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Pelvis, Inflammation, Acute | | 2 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Inflammation, Chronic Active | | 1 1.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 102 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------