TDMS Study 88034-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 06 TIME: 22:35:19
TEST TYPE: CHRONIC 30-MONTH CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88034B
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 06 TIME: 22:35:19
TEST TYPE: CHRONIC 30-MONTH CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88034B
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest OZONE DATE: 05/08/95
EXPERIMENT: 88034 TEST: 06 TIME: 22:35:19
TEST TYPE: CHRONIC 30-MONTH CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95239 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88034B
PATHOLOGIST: S. GRUMBEIN CAS: 10028-15-6
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 6 OZONE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Carcinoma
Pituitary Gland: Pars Intermedia
Adenoma
All Organs Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Carcinoma
Lung Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
All Organs Histiocytic Sarcoma
====================================================================================================
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/47 (4%) 1/49 (2%) 1/49 (2%) | 1/48 (2%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 13.8% 5.3% 8.3% | 5.3% 0.0% 10.0% |
|TERMINAL (d) | 1/13 (8%) 0/11 (0%) 1/12 (8%) | 0/9 (0%) 0/12 (0%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 903 838 911 (T) | 841 --- 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.437N P=0.572N P=0.545N | P=0.653N P=0.453N P=0.737N |
|INCIDENTAL TUMOR | P=0.397N P=0.479N P=0.523N | P=0.649N P=0.507N P=0.738N |
|LOGISTIC REGRESSION | P=0.435N P=0.540N P=0.565N | P=0.668N P=0.478N P=0.757N |
|COCHRAN-ARMITAGE | P=0.365N | P=0.660N |
|FISHER EXACT | P=0.484N P=0.484N | P=0.495N P=0.742N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/48 (0%) 0/49 (0%) | 2/48 (4%) 2/49 (4%) 1/50 (2%) |
|ADJUSTED (b) | 7.1% 0.0% 0.0% | 13.2% 10.5% 10.0% |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 911 (T) --- --- | 621 678 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297N P=0.548N P=0.531N | P=0.369N P=0.635N P=0.473N |
|INCIDENTAL TUMOR | P=0.297N P=0.548N P=0.531N | P=0.356N P=0.581N P=0.475N |
|LOGISTIC REGRESSION | P=0.297N P=0.548N P=0.531N | P=0.379N P=0.697N P=0.493N |
|COCHRAN-ARMITAGE | P=0.267N | P=0.376N |
|FISHER EXACT | P=0.500N P=0.495N | P=0.684N P=0.485N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/48 (0%) 0/49 (0%) | 2/48 (4%) 2/49 (4%) 2/50 (4%) |
|ADJUSTED (b) | 7.1% 0.0% 0.0% | 13.2% 10.5% 16.9% |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 911 (T) --- --- | 621 678 880 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297N P=0.548N P=0.531N | P=0.577N P=0.635N P=0.658N |
|INCIDENTAL TUMOR | P=0.297N P=0.548N P=0.531N | P=0.571N P=0.581N P=0.667N |
|LOGISTIC REGRESSION | P=0.297N P=0.548N P=0.531N | P=0.594N P=0.697N P=0.692N |
|COCHRAN-ARMITAGE | P=0.267N | P=0.585N |
|FISHER EXACT | P=0.500N P=0.495N | P=0.684N P=0.676N |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.6% | 8.1% 3.1% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 741 | 403 786 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.249 (e) P=0.467 | P=0.149N P=0.465N P=0.233N |
|INCIDENTAL TUMOR | P=0.257 (e) P=0.492 | P=0.190N P=0.677N P=0.291N |
|LOGISTIC REGRESSION | P=0.270 (e) P=0.500 | P=0.150N P=0.604N P=0.240N |
|COCHRAN-ARMITAGE | P=0.269 | P=0.142N |
|FISHER EXACT | (e) P=0.500 | P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/49 (4%) 2/50 (4%) | 1/49 (2%) 3/49 (6%) 1/50 (2%) |
|ADJUSTED (b) | 3.4% 11.0% 6.7% | 2.3% 12.0% 2.3% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | 791 787 677 | 621 571 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.320 P=0.450 P=0.449 | P=0.583N P=0.395 P=0.753N |
|INCIDENTAL TUMOR | P=0.372 P=0.562 P=0.486 | P=0.601N P=0.416 P=0.754N |
|LOGISTIC REGRESSION | P=0.387 P=0.495 P=0.508 | P=0.597N P=0.253 P=0.765 |
|COCHRAN-ARMITAGE | P=0.398 | P=0.602N |
|FISHER EXACT | P=0.500 P=0.508 | P=0.309 P=0.747N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/50 (10%) 4/50 (8%) | 4/50 (8%) 4/50 (8%) 2/50 (4%) |
|ADJUSTED (b) | 24.9% 18.3% 25.4% | 12.2% 22.4% 11.9% |
|TERMINAL (d) | 2/14 (14%) 0/11 (0%) 1/12 (8%) | 0/9 (0%) 2/12 (17%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 482 616 828 | 521 621 530 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.419N P=0.575N P=0.475N | P=0.272N P=0.555N P=0.371N |
|INCIDENTAL TUMOR | P=0.313N P=0.439N P=0.458N | P=0.318N P=0.622 P=0.400N |
|LOGISTIC REGRESSION | P=0.326N P=0.497N P=0.410N | P=0.272N P=0.631 P=0.332N |
|COCHRAN-ARMITAGE | P=0.309N | P=0.274N |
|FISHER EXACT | P=0.500N P=0.370N | P=0.643N P=0.339N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 13.6% 5.3% | 2.8% 8.3% 5.9% |
|TERMINAL (d) | 0/14 (0%) 1/11 (9%) 0/12 (0%) | 0/9 (0%) 1/12 (8%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- 826 819 | 749 911 (T) 869 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.319 P=0.204 P=0.471 | P=0.628N P=0.719N P=0.752N |
|INCIDENTAL TUMOR | P=0.338 P=0.235 P=0.492 | P=0.625N P=0.736N P=0.755N |
|LOGISTIC REGRESSION | P=0.322 P=0.212 P=0.486 | P=0.636 P=0.747N P=0.759 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.640 |
|FISHER EXACT | P=0.247 P=0.500 | P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 7/50 (14%) 5/50 (10%) | 5/50 (10%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | 24.9% 29.4% 29.3% | 14.6% 30.2% 17.1% |
|TERMINAL (d) | 2/14 (14%) 1/11 (9%) 1/12 (8%) | 0/9 (0%) 3/12 (25%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 482 616 819 | 521 621 530 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.555 P=0.412 P=0.607N | P=0.289N P=0.526N P=0.382N |
|INCIDENTAL TUMOR | P=0.456N P=0.555 P=0.589N | P=0.330N P=0.624 P=0.408N |
|LOGISTIC REGRESSION | P=0.472N P=0.508 P=0.547N | P=0.297N P=0.629 P=0.352N |
|COCHRAN-ARMITAGE | P=0.439N | P=0.297N |
|FISHER EXACT | P=0.500 P=0.500N | P=0.630N P=0.357N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 1/50 (2%) 0/50 (0%) | 0/49 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 2.1% 0.0% | 0.0% 3.4% 11.3% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- 568 --- | --- 805 741 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.727N P=0.522 (e) | P=0.140 P=0.530 P=0.254 |
|INCIDENTAL TUMOR | P=0.519N P=0.638 (e) | P=0.154 P=0.494 P=0.252 |
|LOGISTIC REGRESSION | P=0.723N P=0.436 (e) | P=0.139 P=0.510 P=0.236 |
|COCHRAN-ARMITAGE | P=0.728N | P=0.145 |
|FISHER EXACT | P=0.505 (e) | P=0.505 P=0.253 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/49 (27%) 18/50 (36%) 12/50 (24%) | 13/49 (27%) 16/50 (32%) 13/50 (26%) |
|ADJUSTED (b) | 64.8% 72.2% 55.2% | 50.9% 62.4% 69.3% |
|TERMINAL (d) | 8/14 (57%) 6/11 (55%) 4/12 (33%) | 2/9 (22%) 4/12 (33%) 6/10 (60%) |
|FIRST INCIDENCE (DAYS) | 605 386 469 | 527 616 416 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.438 P=0.095 P=0.515 | P=0.516N P=0.565 P=0.580N |
|INCIDENTAL TUMOR | P=0.483N P=0.200 P=0.580N | P=0.504N P=0.373 P=0.559N |
|LOGISTIC REGRESSION | P=0.530N P=0.196 P=0.578 | P=0.542N P=0.413 P=0.577N |
|COCHRAN-ARMITAGE | P=0.431N | P=0.519N |
|FISHER EXACT | P=0.212 P=0.477N | P=0.353 P=0.567N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/49 (41%) 17/50 (34%) 21/50 (42%) | 19/49 (39%) 18/50 (36%) 8/50 (16%) |
|ADJUSTED (b) | 57.4% 52.3% 57.1% | 69.2% 68.2% 42.4% |
|TERMINAL (d) | 2/14 (14%) 2/11 (18%) 2/12 (17%) | 3/9 (33%) 6/12 (50%) 3/10 (30%) |
|FIRST INCIDENCE (DAYS) | 328 446 297 | 547 691 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.302 P=0.480N P=0.335 | P=0.018N* P=0.264N P=0.021N* |
|INCIDENTAL TUMOR | P=0.481 P=0.341N P=0.563 | P=0.005N** P=0.399N P=0.007N** |
|LOGISTIC REGRESSION | P=0.528N P=0.320N P=0.565N | P=0.009N** P=0.379N P=0.011N* |
|COCHRAN-ARMITAGE | P=0.491 | P=0.009N** |
|FISHER EXACT | P=0.311N P=0.534 | P=0.469N P=0.010N** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/49 (63%) 34/50 (68%) 31/50 (62%) | 27/49 (55%) 28/50 (56%) 21/50 (42%) |
|ADJUSTED (b) | 87.0% 87.1% 81.3% | 80.9% 85.8% 93.7% |
|TERMINAL (d) | 10/14 (71%) 7/11 (64%) 6/12 (50%) | 4/9 (44%) 8/12 (67%) 9/10 (90%) |
|FIRST INCIDENCE (DAYS) | 328 386 297 | 527 616 416 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.284 P=0.217 P=0.325 | P=0.177N P=0.315N P=0.200N |
|INCIDENTAL TUMOR | P=0.516N P=0.346 P=0.561N | P=0.084N P=0.547N P=0.108N |
|LOGISTIC REGRESSION | P=0.484N P=0.389 P=0.538N | P=0.124N P=0.508N P=0.144N |
|COCHRAN-ARMITAGE | P=0.488N | P=0.113N |
|FISHER EXACT | P=0.388 P=0.531N | P=0.545 P=0.135N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/49 (63%) 34/50 (68%) 31/50 (62%) | 27/49 (55%) 28/50 (56%) 21/50 (42%) |
|ADJUSTED (b) | 87.0% 87.1% 81.3% | 80.9% 85.8% 93.7% |
|TERMINAL (d) | 10/14 (71%) 7/11 (64%) 6/12 (50%) | 4/9 (44%) 8/12 (67%) 9/10 (90%) |
|FIRST INCIDENCE (DAYS) | 328 386 297 | 527 616 416 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.284 P=0.217 P=0.325 | P=0.177N P=0.315N P=0.200N |
|INCIDENTAL TUMOR | P=0.516N P=0.346 P=0.561N | P=0.084N P=0.547N P=0.108N |
|LOGISTIC REGRESSION | P=0.484N P=0.389 P=0.538N | P=0.124N P=0.508N P=0.144N |
|COCHRAN-ARMITAGE | P=0.488N | P=0.113N |
|FISHER EXACT | P=0.388 P=0.531N | P=0.545 P=0.135N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 2/50 (4%) | 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 9.4% | 0.0% 2.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 730 | --- 544 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077 (e) P=0.195 | P=0.727N P=0.521 (e) |
|INCIDENTAL TUMOR | P=0.083 (e) P=0.229 | P=0.619 P=0.186 (e) |
|LOGISTIC REGRESSION | P=0.093 (e) P=0.234 | P=0.686 P=0.277 (e) |
|COCHRAN-ARMITAGE | P=0.097 | P=0.728N |
|FISHER EXACT | (e) P=0.253 | P=0.505 (e) |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/49 (16%) 8/49 (16%) 9/50 (18%) | 3/50 (6%) 3/49 (6%) 11/50 (22%) |
|ADJUSTED (b) | 33.9% 32.8% 50.6% | 15.7% 8.9% 56.1% |
|TERMINAL (d) | 3/14 (21%) 2/11 (18%) 5/12 (42%) | 1/9 (11%) 0/12 (0%) 4/10 (40%) |
|FIRST INCIDENCE (DAYS) | 391 678 620 | 721 616 455 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332 P=0.518 P=0.389 | P=0.012 * P=0.586N P=0.035 * |
|INCIDENTAL TUMOR | P=0.497 P=0.587N P=0.596 | P=0.010 ** P=0.618N P=0.024 * |
|LOGISTIC REGRESSION | P=0.427 P=0.606N P=0.473 | P=0.009 ** P=0.633 P=0.020 * |
|COCHRAN-ARMITAGE | P=0.465 | P=0.009 ** |
|FISHER EXACT | P=0.607N P=0.518 | P=0.651 P=0.020 * |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/49 (16%) 15/49 (31%) 18/50 (36%) | 3/50 (6%) 5/49 (10%) 2/50 (4%) |
|ADJUSTED (b) | 42.3% 65.3% 70.9% | 12.2% 26.4% 13.9% |
|TERMINAL (d) | 4/14 (29%) 5/11 (45%) 6/12 (50%) | 0/9 (0%) 2/12 (17%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 805 693 609 | 521 721 833 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.033 * P=0.009 ** | P=0.395N P=0.494 P=0.473N |
|INCIDENTAL TUMOR | P=0.011 * P=0.075 P=0.019 * | P=0.468N P=0.191 P=0.577N |
|LOGISTIC REGRESSION | P=0.005 ** P=0.050 P=0.007 ** | P=0.423N P=0.328 P=0.496N |
|COCHRAN-ARMITAGE | P=0.019 * | P=0.421N |
|FISHER EXACT | P=0.076 P=0.022 * | P=0.346 P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/49 (33%) 22/49 (45%) 21/50 (42%) | 6/50 (12%) 8/49 (16%) 12/50 (24%) |
|ADJUSTED (b) | 66.0% 76.3% 77.0% | 26.0% 33.1% 58.0% |
|TERMINAL (d) | 7/14 (50%) 6/11 (55%) 7/12 (58%) | 1/9 (11%) 2/12 (17%) 4/10 (40%) |
|FIRST INCIDENCE (DAYS) | 391 678 609 | 521 616 455 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.086 P=0.078 P=0.107 | P=0.096 P=0.547 P=0.143 |
|INCIDENTAL TUMOR | P=0.200 P=0.167 P=0.288 | P=0.065 P=0.282 P=0.081 |
|LOGISTIC REGRESSION | P=0.127 P=0.140 P=0.149 | P=0.072 P=0.341 P=0.096 |
|COCHRAN-ARMITAGE | P=0.200 | P=0.074 |
|FISHER EXACT | P=0.150 P=0.226 | P=0.371 P=0.096 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 20.5% 7.1% 12.5% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 824 785 749 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.582 P=0.400N P=0.656N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.570N P=0.497N P=0.643N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.580 P=0.452N P=0.653 |
|COCHRAN-ARMITAGE | (e) | P=0.588N |
|FISHER EXACT | (e) (e) | P=0.500N P=0.661N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 4/50 (8%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 22.9% 7.1% 12.5% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 775 785 749 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.437N P=0.256N P=0.518N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.398N P=0.339N P=0.478N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.424N P=0.298N P=0.512N |
|COCHRAN-ARMITAGE | (e) | P=0.417N |
|FISHER EXACT | (e) (e) | P=0.339N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 4/50 (8%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 22.9% 7.1% 12.5% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 775 785 749 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.437N P=0.256N P=0.518N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.398N P=0.339N P=0.478N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.424N P=0.298N P=0.512N |
|COCHRAN-ARMITAGE | (e) | P=0.417N |
|FISHER EXACT | (e) (e) | P=0.339N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 4/49 (8%) 2/48 (4%) 2/50 (4%) |
|ADJUSTED (b) | | 13.1% 6.7% 20.0% |
|TERMINAL (d) | | 0/9 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE (DAYS) | | 537 754 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.253N P=0.282N P=0.337N |
|INCIDENTAL TUMOR | | P=0.266N P=0.485N P=0.346N |
|LOGISTIC REGRESSION | | P=0.247N P=0.382N P=0.331N |
|COCHRAN-ARMITAGE | | P=0.246N |
|FISHER EXACT | | P=0.349N P=0.329N |
|=================================================================================================================================|
| |
|Ovary |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/49 (2%) 0/48 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 10.0% 0.0% 12.3% |
|TERMINAL (d) | | 0/9 (0%) 0/12 (0%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | | 884 --- 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.379 P=0.464N P=0.527 |
|INCIDENTAL TUMOR | | P=0.381 P=0.520N P=0.526 |
|LOGISTIC REGRESSION | | P=0.359 P=0.459N P=0.498 |
|COCHRAN-ARMITAGE | | P=0.367 |
|FISHER EXACT | | P=0.505N P=0.508 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 1/49 (2%) 0/48 (0%) | 19/48 (40%) 11/48 (23%) 12/49 (24%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% | 71.7% 50.8% 70.5% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/11 (0%) | 4/9 (44%) 4/12 (33%) 6/10 (60%) |
|FIRST INCIDENCE (DAYS) | --- 651 --- | 547 691 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.723 P=0.510 (e) | P=0.077N P=0.028N* P=0.110N |
|INCIDENTAL TUMOR | P=0.733N P=0.551 (e) | P=0.041N* P=0.040N* P=0.055N |
|LOGISTIC REGRESSION | P=0.721N P=0.480 (e) | P=0.072N P=0.039N* P=0.098N |
|COCHRAN-ARMITAGE | P=0.729N | P=0.064N |
|FISHER EXACT | P=0.510 (e) | P=0.061N P=0.084N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 1/49 (2%) 0/48 (0%) | 19/48 (40%) 12/48 (25%) 12/49 (24%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% | 71.7% 52.5% 70.5% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/11 (0%) | 4/9 (44%) 4/12 (33%) 6/10 (60%) |
|FIRST INCIDENCE (DAYS) | --- 651 --- | 547 691 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.723 P=0.510 (e) | P=0.080N P=0.045N* P=0.110N |
|INCIDENTAL TUMOR | P=0.733N P=0.551 (e) | P=0.041N* P=0.066N P=0.055N |
|LOGISTIC REGRESSION | P=0.721N P=0.480 (e) | P=0.074N P=0.063N P=0.098N |
|COCHRAN-ARMITAGE | P=0.729N | P=0.065N |
|FISHER EXACT | P=0.510 (e) | P=0.095N P=0.084N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/47 (4%) 0/49 (0%) 0/48 (0%) | 1/48 (2%) 0/48 (0%) 3/49 (6%) |
|ADJUSTED (b) | 8.2% 0.0% 0.0% | 4.8% 0.0% 23.8% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/11 (0%) | 0/9 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE (DAYS) | 605 --- --- | 840 --- 847 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115N P=0.264N P=0.275N | P=0.187 P=0.473N P=0.339 |
|INCIDENTAL TUMOR | P=0.035N* P=0.143N P=0.103N | P=0.191 P=0.513N P=0.336 |
|LOGISTIC REGRESSION | P=0.091N P=0.231N P=0.231N | P=0.167 P=0.484N P=0.302 |
|COCHRAN-ARMITAGE | P=0.092N | P=0.181 |
|FISHER EXACT | P=0.237N P=0.242N | P=0.500N P=0.316 |
|=================================================================================================================================|
| |
|Skin |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 7.1% 9.9% 5.6% | 2.3% 10.2% 0.0% |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 1/12 (8%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | 911 (T) 678 828 | 621 571 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545 P=0.441 P=0.720 | P=0.342N P=0.553 P=0.495N |
|INCIDENTAL TUMOR | P=0.602 P=0.520 P=0.739 | P=0.333N P=0.694 P=0.500N |
|LOGISTIC REGRESSION | P=0.598 P=0.497 P=0.725 | P=0.363N P=0.419 P=0.508N |
|COCHRAN-ARMITAGE | P=0.622N | P=0.360N |
|FISHER EXACT | P=0.500 P=0.753N | P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 6/50 (12%) |
|ADJUSTED (b) | 0.0% 9.3% 0.0% | 6.7% 5.8% 25.9% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | --- 716 --- | 754 595 455 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.628 P=0.214 (e) | P=0.082 P=0.655N P=0.146 |
|INCIDENTAL TUMOR | P=0.667 P=0.285 (e) | P=0.073 P=0.652N P=0.129 |
|LOGISTIC REGRESSION | P=0.663 P=0.240 (e) | P=0.084 P=0.659 P=0.136 |
|COCHRAN-ARMITAGE | P=0.669 | P=0.080 |
|FISHER EXACT | P=0.247 (e) | P=0.691N P=0.134 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 3/49 (6%) 4/50 (8%) | 2/49 (4%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 3.4% 14.5% 18.8% | 5.5% 15.8% 21.8% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 1/12 (8%) | 0/9 (0%) 1/12 (8%) 2/10 (20%) |
|FIRST INCIDENCE (DAYS) | 791 787 677 | 621 571 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.096 P=0.262 P=0.144 | P=0.428 P=0.574 P=0.499 |
|INCIDENTAL TUMOR | P=0.112 P=0.369 P=0.161 | P=0.437 P=0.643 P=0.530 |
|LOGISTIC REGRESSION | P=0.121 P=0.301 P=0.170 | P=0.422 P=0.474 P=0.509 |
|COCHRAN-ARMITAGE | P=0.138 | P=0.421 |
|FISHER EXACT | P=0.309 P=0.187 | P=0.510 P=0.510 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.8% 0.0% 7.1% | 11.1% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | 701 --- 875 | 911 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.237N P=0.151N P=0.396N | P=0.248N P=0.443N P=0.479N |
|INCIDENTAL TUMOR | P=0.186N P=0.111N P=0.330N | P=0.248N P=0.443N P=0.479N |
|LOGISTIC REGRESSION | P=0.194N P=0.120N P=0.336N | P=0.248N P=0.443N P=0.479N |
|COCHRAN-ARMITAGE | P=0.176N | P=0.269N |
|FISHER EXACT | P=0.121N P=0.309N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 11.4% 0.0% 7.1% | 11.1% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 0/12 (0%) | 1/9 (11%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | 840 --- 875 | 911 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436N P=0.289N P=0.590N | P=0.248N P=0.443N P=0.479N |
|INCIDENTAL TUMOR | P=0.380N P=0.242N P=0.527N | P=0.248N P=0.443N P=0.479N |
|LOGISTIC REGRESSION | P=0.414N P=0.263N P=0.567N | P=0.248N P=0.443N P=0.479N |
|COCHRAN-ARMITAGE | P=0.360N | P=0.269N |
|FISHER EXACT | P=0.247N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/49 (2%) 2/50 (4%) | |
|ADJUSTED (b) | 10.3% 5.6% 12.7% | |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 1/12 (8%) | |
|FIRST INCIDENCE (DAYS) | 791 845 808 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.538 P=0.554N P=0.636 | |
|INCIDENTAL TUMOR | P=0.579 P=0.487N P=0.659 | |
|LOGISTIC REGRESSION | P=0.559 P=0.521N P=0.646 | |
|COCHRAN-ARMITAGE | P=0.609 | |
|FISHER EXACT | P=0.508N P=0.691N | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/48 (0%) 0/50 (0%) | 2/49 (4%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 6.7% 0.0% 0.0% | 5.2% 8.3% 10.0% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 903 --- --- | 721 911 (T) 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.308N P=0.562N P=0.545N | P=0.388N P=0.455N P=0.531N |
|INCIDENTAL TUMOR | P=0.269N P=0.471N P=0.508N | P=0.352N P=0.482N P=0.474N |
|LOGISTIC REGRESSION | P=0.306N P=0.548N P=0.549N | P=0.377N P=0.498N P=0.497N |
|COCHRAN-ARMITAGE | P=0.268N | P=0.372N |
|FISHER EXACT | P=0.505N P=0.495N | P=0.500N P=0.492N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/48 (0%) 0/50 (0%) | 2/49 (4%) 1/49 (2%) 1/50 (2%) |
|ADJUSTED (b) | 11.6% 0.0% 0.0% | 5.2% 8.3% 10.0% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 869 --- --- | 721 911 (T) 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.128N P=0.302N P=0.292N | P=0.388N P=0.455N P=0.531N |
|INCIDENTAL TUMOR | P=0.093N P=0.207N P=0.246N | P=0.352N P=0.482N P=0.474N |
|LOGISTIC REGRESSION | P=0.119N P=0.272N P=0.283N | P=0.377N P=0.498N P=0.497N |
|COCHRAN-ARMITAGE | P=0.095N | P=0.372N |
|FISHER EXACT | P=0.253N P=0.242N | P=0.500N P=0.492N |
|=================================================================================================================================|
| |
|Uterus |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 2.8% 0.0% 15.3% |
|TERMINAL (d) | | 0/9 (0%) 0/12 (0%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | | 749 --- 869 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.372 P=0.484N P=0.522 |
|INCIDENTAL TUMOR | | P=0.375 P=0.512N P=0.519 |
|LOGISTIC REGRESSION | | P=0.352 P=0.519N P=0.492 |
|COCHRAN-ARMITAGE | | P=0.360 |
|FISHER EXACT | | P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 4/50 (8%) 2/50 (4%) 6/50 (12%) |
|ADJUSTED (b) | | 28.6% 6.6% 20.6% |
|TERMINAL (d) | | 2/9 (22%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | | 805 792 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.273 P=0.261N P=0.363 |
|INCIDENTAL TUMOR | | P=0.312 P=0.313N P=0.398 |
|LOGISTIC REGRESSION | | P=0.283 P=0.293N P=0.359 |
|COCHRAN-ARMITAGE | | P=0.290 |
|FISHER EXACT | | P=0.339N P=0.370 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 3/50 (6%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | 0.0% 12.0% 0.0% | 16.3% 0.0% 26.6% |
|TERMINAL (d) | 0/14 (0%) 1/11 (9%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE (DAYS) | --- 735 --- | 749 --- 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.631 P=0.207 (e) | P=0.430 P=0.104N P=0.533 |
|INCIDENTAL TUMOR | P=0.647 P=0.235 (e) | P=0.428 P=0.132N P=0.528 |
|LOGISTIC REGRESSION | P=0.654 P=0.235 (e) | P=0.395 P=0.110N P=0.487 |
|COCHRAN-ARMITAGE | P=0.669 | P=0.406 |
|FISHER EXACT | P=0.247 (e) | P=0.121N P=0.500 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 5/50 (10%) | 2/50 (4%) 7/50 (14%) 5/50 (10%) |
|ADJUSTED (b) | 10.3% 18.4% 23.3% | 5.5% 33.1% 30.6% |
|TERMINAL (d) | 1/14 (7%) 0/11 (0%) 1/12 (8%) | 0/9 (0%) 2/12 (17%) 2/10 (20%) |
|FIRST INCIDENCE (DAYS) | 791 568 677 | 621 571 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.130 P=0.190 P=0.166 | P=0.215 P=0.158 P=0.229 |
|INCIDENTAL TUMOR | P=0.195 P=0.309 P=0.189 | P=0.212 P=0.130 P=0.239 |
|LOGISTIC REGRESSION | P=0.169 P=0.219 P=0.189 | P=0.187 P=0.086 P=0.214 |
|COCHRAN-ARMITAGE | P=0.178 | P=0.195 |
|FISHER EXACT | P=0.218 P=0.218 | P=0.080 P=0.218 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) 5/50 (10%) | 5/50 (10%) 7/50 (14%) 9/50 (18%) |
|ADJUSTED (b) | 10.3% 28.2% 23.3% | 20.9% 33.1% 52.3% |
|TERMINAL (d) | 1/14 (7%) 1/11 (9%) 1/12 (8%) | 0/9 (0%) 2/12 (17%) 4/10 (40%) |
|FIRST INCIDENCE (DAYS) | 791 568 677 | 621 571 646 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.140 P=0.067 P=0.166 | P=0.185 P=0.524 P=0.227 |
|INCIDENTAL TUMOR | P=0.206 P=0.125 P=0.189 | P=0.177 P=0.463 P=0.224 |
|LOGISTIC REGRESSION | P=0.182 P=0.083 P=0.189 | P=0.145 P=0.401 P=0.183 |
|COCHRAN-ARMITAGE | P=0.195 | P=0.157 |
|FISHER EXACT | P=0.080 P=0.218 | P=0.380 P=0.194 |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) | 4/50 (8%) 0/50 (0%) 3/50 (6%) |
|ADJUSTED (b) | 3.7% 2.8% 8.3% | 25.9% 0.0% 8.1% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 1/12 (8%) | 1/9 (11%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | 807 709 911 (T) | 826 --- 647 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.597 P=0.741 P=0.725 | P=0.394N P=0.038N* P=0.483N |
|INCIDENTAL TUMOR | P=0.620 P=0.715N P=0.739 | P=0.390N P=0.061N P=0.478N |
|LOGISTIC REGRESSION | P=0.627 P=0.763 P=0.731 | P=0.407N P=0.044N* P=0.504N |
|COCHRAN-ARMITAGE | P=0.640 | P=0.406N |
|FISHER EXACT | P=0.753N P=0.753N | P=0.059N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 4/50 (8%) | 17/50 (34%) 12/50 (24%) 16/50 (32%) |
|ADJUSTED (b) | 12.7% 16.4% 18.5% | 60.7% 42.7% 52.2% |
|TERMINAL (d) | 1/14 (7%) 1/11 (9%) 1/12 (8%) | 2/9 (22%) 2/12 (17%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 578 386 623 | 527 616 647 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.367 P=0.455 P=0.440 | P=0.489N P=0.117N P=0.525N |
|INCIDENTAL TUMOR | P=0.494 P=0.511 P=0.651N | P=0.428N P=0.193N P=0.470N |
|LOGISTIC REGRESSION | P=0.425 P=0.481 P=0.492 | P=0.455N P=0.171N P=0.501N |
|COCHRAN-ARMITAGE | P=0.424 | P=0.457N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.189N P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 3/50 (6%) | 13/50 (26%) 12/50 (24%) 13/50 (26%) |
|ADJUSTED (b) | 9.4% 14.0% 11.1% | 46.2% 42.7% 48.0% |
|TERMINAL (d) | 1/14 (7%) 1/11 (9%) 0/12 (0%) | 1/9 (11%) 2/12 (17%) 1/10 (10%) |
|FIRST INCIDENCE (DAYS) | 578 386 623 | 527 616 651 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.369 P=0.463 P=0.457 | P=0.507 P=0.358N P=0.542 |
|INCIDENTAL TUMOR | P=0.507 P=0.475 P=0.663N | P=0.526N P=0.515N P=0.575N |
|LOGISTIC REGRESSION | P=0.413 P=0.475 P=0.501 | P=0.547 P=0.501N P=0.593 |
|COCHRAN-ARMITAGE | P=0.412 | P=0.546N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.500N P=0.590N |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.6% | 8.1% 3.1% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 741 | 403 786 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.249 (e) P=0.467 | P=0.149N P=0.465N P=0.233N |
|INCIDENTAL TUMOR | P=0.257 (e) P=0.492 | P=0.190N P=0.677N P=0.291N |
|LOGISTIC REGRESSION | P=0.270 (e) P=0.500 | P=0.150N P=0.604N P=0.240N |
|COCHRAN-ARMITAGE | P=0.269 | P=0.142N |
|FISHER EXACT | (e) P=0.500 | P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.6% | 8.1% 3.1% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/11 (0%) 0/12 (0%) | 0/9 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 741 | 403 786 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.249 (e) P=0.467 | P=0.149N P=0.465N P=0.233N |
|INCIDENTAL TUMOR | P=0.257 (e) P=0.492 | P=0.190N P=0.677N P=0.291N |
|LOGISTIC REGRESSION | P=0.270 (e) P=0.500 | P=0.150N P=0.604N P=0.240N |
|COCHRAN-ARMITAGE | P=0.269 | P=0.142N |
|FISHER EXACT | (e) P=0.500 | P=0.500N P=0.247N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 32/50 (64%) 23/50 (46%) | 39/50 (78%) 32/50 (64%) 35/50 (70%) |
|ADJUSTED (b) | 88.8% 86.8% 87.2% | 94.0% 87.6% 100.0% |
|TERMINAL (d) | 11/14 (79%) 7/11 (64%) 9/12 (75%) | 7/9 (78%) 8/12 (67%) 10/10 (100%) |
|FIRST INCIDENCE (DAYS) | 391 386 469 | 521 616 416 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.500N P=0.157 P=0.484N | P=0.303N P=0.055N P=0.345N |
|INCIDENTAL TUMOR | P=0.180N P=0.400 P=0.222N | P=0.211N P=0.068N P=0.241N |
|LOGISTIC REGRESSION | P=0.214N P=0.311 P=0.268N | P=0.229N P=0.066N P=0.253N |
|COCHRAN-ARMITAGE | P=0.183N | P=0.221N |
|FISHER EXACT | P=0.270 P=0.212N | P=0.093N P=0.247N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.5 PPM 1.0 PPM | CONTROL 0.5 PPM 1.0 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 41/50 (82%) 40/50 (80%) | 39/50 (78%) 39/50 (78%) 34/50 (68%) |
|ADJUSTED (b) | 74.8% 92.6% 88.4% | 91.6% 94.3% 85.2% |
|TERMINAL (d) | 5/14 (36%) 8/11 (73%) 7/12 (58%) | 6/9 (67%) 10/12 (83%) 5/10 (50%) |
|FIRST INCIDENCE (DAYS) | 328 386 297 | 403 544 455 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * P=0.041 * P=0.043 * | P=0.292N P=0.241N P=0.320N |
|INCIDENTAL TUMOR | P=0.011 * P=0.018 * P=0.027 * | P=0.154N P=0.473 P=0.191N |
|LOGISTIC REGRESSION | P=0.015 * P=0.013 * P=0.025 * | P=0.151N P=0.580 P=0.183N |
|COCHRAN-ARMITAGE | P=0.015 * | P=0.150N |
|FISHER EXACT | P=0.013 * P=0.024 * | P=0.595N P=0.184N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 43/50 (86%) 50/50 (100%) 42/50 (84%) | 48/50 (96%) 49/50 (98%) 47/50 (94%) |
|ADJUSTED (b) | 93.2% 100.0% 93.0% | 97.9% 100.0% 100.0% |
|TERMINAL (d) | 11/14 (79%) 11/11 (100%) 9/12 (75%) | 8/9 (89%) 12/12 (100%) 10/10 (100%) |
|FIRST INCIDENCE (DAYS) | 328 386 297 | 403 544 416 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.276 P=0.099 P=0.331 | P=0.473N P=0.232N P=0.501N |
|INCIDENTAL TUMOR | P=0.430N P=0.018 * P=0.505N | P=0.413N P=0.481 P=0.518N |
|LOGISTIC REGRESSION | P=0.287N P=0.010 ** P=0.503N | P=0.399N P=0.470 P=0.497N |
|COCHRAN-ARMITAGE | P=0.434N | P=0.399N |
|FISHER EXACT | P=0.006 ** P=0.500N | P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 05/08/95 EXPERIMENT: 88034 TEST: 06 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 6 OZONE
TERMINAL SACRIFICE AT 131 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).