TDMS Study 88034-05 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
OZONE
NTP Experiment-Test: 88034-05 Report: PEIRPT05
Study Type: CHRONIC 30-MONTH Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 56 56 56
Scheduled Sacrifice 6 6 6
Early Deaths
Moribund Sacrifice 36 37 40
Natural Death 8 7 3
Survivors
Terminal Sacrifice 6 6 7
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (50)
Intestine Large, Rectum (48) (50) (47)
Polyp Adenomatous 1 (2%)
Intestine Large, Cecum (48) (49) (50)
Intestine Small, Duodenum (47) (49) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Intestine Small, Jejunum (47) (47) (49)
Intestine Small, Ileum (46) (47) (49)
Liver (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (11) (7) (4)
Oral Mucosa (2) (2)
Gingival, Squamous Cell Carcinoma 1 (50%)
Pharyngeal, Squamous Cell Papilloma 2 (100%)
Pancreas (49) (49) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (49) (50) (50)
Stomach, Glandular (49) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 2 (4%)
Adrenal Medulla (50) (49) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 12 (24%) 14 (29%) 12 (24%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) 2 (4%)
Islets, Pancreatic (49) (49) (50)
Carcinoma 2 (4%) 1 (2%) 1 (2%)
Parathyroid Gland (49) (48) (44)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (50)
Carcinoma 1 (2%)
Pars Distalis, Adenoma 44 (88%) 40 (82%) 37 (74%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (49) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 6 (12%) 6 (12%) 3 (6%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 4 (8%) 3 (6%) 4 (8%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (48) (47)
Adenoma 3 (7%) 3 (6%) 6 (13%)
Carcinoma 2 (4%) 3 (6%)
Ovary (50) (50) (50)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (50) (50) (50)
Carcinoma 1 (2%)
Polyp Stromal 5 (10%) 3 (6%) 6 (12%)
Page 3
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (10) (12) (9)
Lymph Node, Bronchial (27) (42) (34)
Lymph Node, Mandibular (47) (44) (46)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (47) (50) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (42) (45) (45)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (44) (47) (48)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Adenoma, Multiple 1 (2%)
Carcinoma 7 (14%) 5 (10%) 7 (14%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 9 (18%) 18 (36%) 20 (40%)
Fibroadenoma, Multiple 10 (20%) 10 (20%) 5 (10%)
Skin (49) (50) (50)
Keratoacanthoma 1 (2%)
Schwannoma Malignant, Metastatic, Uterus 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Benign 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (47) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 2 (4%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%) 1 (2%)
Nose (50) (49) (50)
Chondroma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (49) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Page 5
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 21 (42%) 22 (44%) 20 (40%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 50
Total Primary Neoplasms 143 146 145
Total Animals with Benign Neoplasms 47 45 48
Total Benign Neoplasms 96 106 101
Total Animals with Malignant Neoplasms 34 31 32
Total Malignant Neoplasms 47 40 44
Total Animals with Metastatic Neoplasms 4 2 2
Total Metastatic Neoplasm 4 9 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 56 56 56
Scheduled Sacrifice 6 6 6
Early Deaths
Moribund Sacrifice 47 43 42
Natural Death 3 7 7
Survivors
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (49)
Polyp Adenomatous 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Intestine Large, Cecum (49) (50) (49)
Intestine Small, Duodenum (50) (48) (49)
Intestine Small, Jejunum (50) (46) (46)
Carcinoma 1 (2%)
Intestine Small, Ileum (49) (47) (48)
Liver (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (16) (17) (7)
Sarcoma, Metastatic, Uncertain Primary Site 1 (6%)
Schwannoma Malignant 1 (6%)
Thymoma Malignant, Metastatic, Thymus 1 (6%)
Oral Mucosa (4)
Pharyngeal, Squamous Cell Carcinoma 1 (25%)
Pharyngeal, Squamous Cell Papilloma 2 (50%)
Pancreas (50) (50) (50)
Adenoma 2 (4%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Salivary Glands (50) (49) (50)
Stomach, Forestomach (50) (50) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Stomach, Glandular (50) (50) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Tongue (1)
Hemangiosarcoma 1 (100%)
Page 8
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Medulla (50) (49) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 13 (26%) 11 (22%) 15 (30%)
Bilateral, Pheochromocytoma Benign 15 (30%) 7 (14%) 8 (16%)
Islets, Pancreatic (50) (50) (50)
Adenoma 6 (12%) 2 (4%) 4 (8%)
Carcinoma 5 (10%) 2 (4%) 1 (2%)
Parathyroid Gland (49) (50) (50)
Adenoma 1 (2%)
Pituitary Gland (50) (48) (50)
Pars Distalis, Adenoma 36 (72%) 30 (63%) 34 (68%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 5 (10%) 8 (16%) 5 (10%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Penis (4) (4) (1)
Preputial Gland (50) (48) (50)
Page 9
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Adenoma 1 (2%) 1 (2%)
Carcinoma 3 (6%) 2 (4%)
Prostate (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (50)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 18 (36%) 27 (54%) 27 (54%)
Interstitial Cell, Adenoma 17 (34%) 6 (12%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (20) (13) (13)
Lymph Node, Bronchial (36) (37) (36)
Lymph Node, Mandibular (48) (47) (47)
Hemangiosarcoma, Metastatic, Tongue 1 (2%)
Lymph Node, Mesenteric (49) (49) (49)
Schwannoma Malignant, Metastatic, Mesentery 1 (2%)
Lymph Node, Mediastinal (45) (48) (47)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Spleen (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Thymus (46) (42) (46)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (31) (21) (26)
Skin (50) (50) (49)
Keratoacanthoma 4 (8%) 2 (4%) 4 (8%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Melanoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1) (3) (2)
Histiocytic Sarcoma 1 (50%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (33%)
Schwannoma Malignant, Metastatic, Mesentery 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Benign 1 (2%)
Astrocytoma Malignant 1 (2%) 1 (2%)
Meninges, Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (48) (47)
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Nose (50) (49) (49)
Pleura (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Liposarcoma 1 (2%)
Oncocytoma Benign 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Page 11
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Renal Tubule, Adenoma 3 (6%) 2 (4%) 2 (4%)
Urinary Bladder (50) (50) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 29 (58%) 23 (46%) 29 (58%)
Mesothelioma Malignant 2 (4%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 48 49
Total Primary Neoplasms 174 142 158
Total Animals with Benign Neoplasms 49 46 48
Total Benign Neoplasms 128 104 118
Total Animals with Malignant Neoplasms 35 30 33
Total Malignant Neoplasms 46 38 40
Total Animals with Metastatic Neoplasms 3 5
Total Metastatic Neoplasm 7 20
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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