TDMS Study 88034-05 Pathology Tables
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|
DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|
| 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Adenomatous | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Fatty | 2 2 2 3 3 3 2 3 3 2|
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X X |
Necrosis | |
Thrombosis | 2 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 1 1 2 |
Centrilobular, Necrosis | 3 1 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | 3 |
Artery, Mineralization | |
Fat, Necrosis | 3 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Cyst | |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 2 1 2 |
Basophilic Focus | X |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
Mineralization | |
Necrosis | 3 3 1 3 4 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | |
Necrosis | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|
DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|
| 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 1 2 3 1 1 1 1 2 1 2|
Artery, Mineralization | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 2 2 2 1 |
Hypertrophy | 3 2 3|
Necrosis | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 1 2 3 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 3 2 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Pars Distalis, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 2 2 1 1 1 2 2 1 1 2 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + M + +|
Inflammation, Chronic Active | 4 3 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|
DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|
| 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hemorrhage | |
Renal, Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + + M + + + + M + + + + + M M M + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 1 1 2 |
Hematopoietic Cell Proliferation | |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | 1 |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 3 1 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Fracture | X|
Hyperostosis | 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 |
Mineralization | |
Necrosis | |
Thrombosis | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epiglottis, Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|
DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|
| 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | 3 |
Artery, Mediastinum, Mineralization | |
Artery, Perivascular, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Thrombosis | 2 3 4 2|
Lateral Wall, Hyperplasia | 1 3 |
Lateral Wall, Metaplasia, Squamous | 3 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 1 2 1 2 1 1 2 1 2 1 2 2 1 2 2 2 2 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Mineralization | |
Nephropathy | 3 3 2 2 1 3 4 2 1 3 2 2 2 3 2 2 3 2 2 2 1 3 1|
Pelvis, Dilatation | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|
| 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Adenomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Fatty | 2 1 1 1 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X|
Necrosis | 2 2 |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 1 1 2 3 2 |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | |
Artery, Mineralization | 3 |
Fat, Necrosis | 2 3 2 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Cyst | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 1 2 2 2 1 2|
Basophilic Focus | |
Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Mineralization | 1 |
Necrosis | 3 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mineralization | 1 1 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|
| 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 1 2 1 2 3 1 1 2|
Artery, Mineralization | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 3 2 2 2 2 4 2 2 1 2|
Hypertrophy | 2 2 |
Necrosis | |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 3 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 2 2 1 2 2 2 3 2 2 2 1 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + I + + M + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|
| 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hemorrhage | 1 |
Renal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + + M M M + + + M M M M + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + M + + + + M + + + M M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + I M + + + + M + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperkeratosis | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 |
Fracture | |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 1 |
Necrosis | 2 |
Thrombosis | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epiglottis, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Artery, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|
DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|
| 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | |
Artery, Mediastinum, Mineralization | 3 |
Artery, Perivascular, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 2 2 3 |
Thrombosis | 3 1 |
Lateral Wall, Hyperplasia | 2 |
Lateral Wall, Metaplasia, Squamous | 2 3 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 2 2 1 1 2 2 1 1 2 1 2 1 1 1 2 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 3 |
Mineralization | 3 |
Nephropathy | 2 3 4 4 1 2 2 2 3 1 3 3 3 4 2 2 2 2 2 2|
Pelvis, Dilatation | 3 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 6| 5| 7| 6| | |
DAY ON TEST | 7| 5| 7| 7| 5| 9| | |
| 4| 9| 8| 7| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 48 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 48 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 47 |
Hyperplasia, Adenomatous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X X | 37 |
Clear Cell Focus | X | 1 |
Degeneration, Fatty | 1 2 3 | 18 2.1|
Eosinophilic Focus | | 3 |
Hepatodiaphragmatic Nodule | | 3 |
Mixed Cell Focus | X X X | 11 |
Necrosis | | 2 2.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 3 | 1 3.0|
Bile Duct, Hyperplasia | 2 | 15 1.8|
Centrilobular, Necrosis | 1 2 | 8 1.9|
__________________________________________________________________________|____________|
Mesentery | + | 11 |
Inflammation, Chronic Active | | 1 3.0|
Artery, Mineralization | | 1 3.0|
Fat, Necrosis | | 6 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Gingival, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 49 |
Atrophy | 4 1 1 | 20 1.7|
Basophilic Focus | | 1 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Hyperplasia, Squamous | | 2 2.0|
Mineralization | | 1 1.0|
Necrosis | 4 | 11 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 6| 5| 7| 6| | |
DAY ON TEST | 7| 5| 7| 7| 5| 9| | |
| 4| 9| 8| 7| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 49 |
Inflammation, Acute | | 1 2.0|
Mineralization | | 3 1.7|
Necrosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | 2 1 1 | 30 1.6|
Artery, Mineralization | | 1 3.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 50 |
Atrophy | | 1 2.0|
Hyperplasia | 2 2 2 | 19 2.1|
Hypertrophy | 1 | 6 2.2|
Necrosis | | 1 2.0|
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | | 9 2.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 50 |
Hyperplasia | 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 49 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
Hyperplasia | 2 | 4 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Hyperplasia | 2 1 1 2 2 2 | 37 1.7|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 6| 5| 7| 6| | |
DAY ON TEST | 7| 5| 7| 7| 5| 9| | |
| 4| 9| 8| 7| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 4 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 50 |
Cyst | 3 | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 50 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 10 |
Renal, Hemorrhage | | 1 1.0|
Renal, Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M + + | 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + | 47 |
Infiltration Cellular, Plasma Cell | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 42 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Fibrosis | | 6 1.7|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 50 |
Galactocele | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 49 |
Cyst | | 1 1.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic Active | 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Fibrous Osteodystrophy | | 1 4.0|
Fracture | | 1 |
Hyperostosis | | 2 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 6| 5| 7| 6| | |
DAY ON TEST | 7| 5| 7| 7| 5| 9| | |
| 4| 9| 8| 7| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | | 2 2.5|
Mineralization | | 1 1.0|
Necrosis | | 1 2.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 49 |
Inflammation, Chronic Active | | 1 4.0|
Epiglottis, Metaplasia, Squamous | 3 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.0|
Artery, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Artery, Mediastinum, Mineralization | | 1 3.0|
Artery, Perivascular, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
Inflammation, Suppurative | | 6 2.5|
Thrombosis | 3 3 | 8 2.6|
Lateral Wall, Hyperplasia | 1 | 4 1.8|
Lateral Wall, Metaplasia, Squamous | | 5 2.4|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 1 2 1 | 48 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Cyst | 2 | 1 2.0|
Infarct | | 1 3.0|
Mineralization | | 1 3.0|
Nephropathy | 3 2 3 3 3 2 | 49 2.4|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 6| 5| 7| 6| | |
DAY ON TEST | 7| 5| 7| 7| 5| 9| | |
| 4| 9| 8| 7| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|
DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|
| 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Necrosis | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 4 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Fatty | 1 1 2 2 1 2 2 1 2 3 3 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 3 |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 2 2 |
Centrilobular, Necrosis | 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Artery, Inflammation, Chronic Active | 3 |
Artery, Mineralization | 2 |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + |
Atrophy | 2 2 2 2 1 1 1 |
Basophilic Focus | X |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + |
Necrosis | 3 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 3 |
Necrosis | |
__________________________________________________________________________|
Tongue | + |
Hyperplasia | 4 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|
DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|
| 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 1 1 2 3 1 1 2 2 2 1 2 2 1 3 |
Artery, Mineralization | 3 |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + |
Atrophy | 2 |
Hyperplasia | 1 2 2 1 2 2 2 2 2 2 2 |
Hypertrophy | 2 2 2 |
Necrosis | 2 |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 2 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + |
Hyperplasia | 2 1 2 2 3 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + |
C-Cell, Hyperplasia | 1 1 2 1 2 2 2 2 3 2 1 2 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Thrombosis | |
Endometrium, Hyperplasia | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + |
Inflammation, Granulomatous | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|
DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|
| 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Pancreatic, Inflammation, | |
Granulomatous | 2 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + A M + + + |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + M + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + |
Depletion Cellular | |
Fibrosis | 2 3 2 |
Hematopoietic Cell Proliferation | 3 3 |
Hemorrhage | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + M + + + M + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 3 |
Hyperostosis | 2 3 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + A + + + + |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Congestion, Chronic | |
Hemorrhage | |
Inflammation, Chronic Active | 2 |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia | 2 2 1 2 2 3 2 2 2 2 2 2 2 1 2 1 1 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 |
Artery, Mediastinum, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|
DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|
| 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Fibrosis | 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + |
Inflammation, Suppurative | 3 |
Thrombosis | 2 1 3 2 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 2 2 1 3 2 2 2 2 2 2 1 2 1 2 1 1 1 3 3 2 2 1 |
Lateral Wall, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 1 1 2 2 1 2 2 |
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 2 1 2 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 2 2 1 1 2 1 2 2 2 1 2 3 2 1 2 1 2 2 2 2 |
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | A + |
Cornea, Inflammation, Chronic Active | 3 |
Cornea, Mineralization | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
Nephropathy | 2 2 2 3 4 3 3 2 2 2 3 3 1 4 1 4 2 3 2 4 |
Pelvis, Dilatation | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + I + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|
DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|
| 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Acute | 3 |
Necrosis | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Fatty | 1 3 2 3 2 1 2 2 1 2|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 2 3 1 1 2 2 |
Centrilobular, Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + + +|
Artery, Inflammation, Chronic Active | |
Artery, Mineralization | |
Fat, Necrosis | 2 3 3|
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 3 |
Basophilic Focus | |
Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 4 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 3 3|
__________________________________________________________________________|
Tongue | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|
DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|
| 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 1 1 1 3 2 2 1 1 2 2 |
Artery, Mineralization | |
Atrium, Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Hyperplasia | 2 2 2 2 2 2 1 2 2 1 2 1 |
Hypertrophy | 2 |
Necrosis | |
Thrombosis | 2 |
Vacuolization Cytoplasmic | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 1 2 1 2 1 2 2 2 1 1 3 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 2 |
Endometrium, Hyperplasia | 4 |
__________________________________________________________________________|
Vagina | +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|
DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|
| 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + +|
Pancreatic, Inflammation, | |
Granulomatous | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + + + + + M + M + M + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 |
Fibrosis | 2 1 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3|
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 |
Hyperostosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + I + + + + + +|
Epiglottis, Metaplasia, Squamous | 1 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | 3 |
Hemorrhage | 1 |
Inflammation, Chronic Active | |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 2 1 |
Alveolar Epithelium, Metaplasia | 1 1 2 1 2 1 1 2 2 2 2 2 1 2 1 2 2 1 2 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Artery, Mediastinum, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|
DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|
| 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Fibrosis | 1 1 1 1 1 1 1 2 2 1 2 1 2 1 2 2 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 2 2|
Thrombosis | 2 2 4 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 2 2 2 1 2 2 1 1 2 2 1 1 2 2 2 2 2 2 2 1|
Lateral Wall, Hyperplasia | 2 1 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Lateral Wall, Metaplasia, Squamous | 1 2 1 1 2 2 2 1 1 1 1 3|
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 2 2 2 2 2 2 1 2 2 1 3 2 2 2 1 2 2 3 1 1 2|
Olfactory Epithelium, Metaplasia | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Nephropathy | 4 2 2 4 2 2 4 2 2 2 1 2 3 2 4 1 4 2 3 2 4 1|
Pelvis, Dilatation | 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 5| 6| 8| 8| | |
DAY ON TEST | 1| 2| 8| 1| 7| 7| | |
| 7| 3| 0| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
Inflammation, Acute | | 1 3.0|
Necrosis | | 1 3.0|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 7 2.1|
Basophilic Focus | X X X | 39 |
Clear Cell Focus | X | 5 |
Degeneration, Fatty | 3 | 22 1.9|
Eosinophilic Focus | X | 3 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 7 |
Inflammation, Granulomatous | 2 | 2 2.5|
Mixed Cell Focus | X X | 8 |
Bile Duct, Hyperplasia | 1 2 | 12 1.7|
Centrilobular, Necrosis | | 5 1.6|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Artery, Inflammation, Chronic Active | | 1 3.0|
Artery, Mineralization | | 1 2.0|
Fat, Necrosis | | 6 2.5|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 49 |
Atrophy | 1 2 | 14 1.6|
Basophilic Focus | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Necrosis | 3 | 9 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Mineralization | | 2 2.5|
Necrosis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 5| 6| 8| 8| | |
DAY ON TEST | 1| 2| 8| 1| 7| 7| | |
| 7| 3| 0| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Cardiomyopathy | 2 2 2 | 35 1.7|
Artery, Mineralization | | 1 3.0|
Atrium, Thrombosis | | 4 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 49 |
Atrophy | | 3 2.0|
Hyperplasia | 3 2 | 25 1.8|
Hypertrophy | 3 | 5 2.2|
Necrosis | | 1 2.0|
Thrombosis | | 2 2.5|
Vacuolization Cytoplasmic | | 7 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 49 |
Hyperplasia | 2 | 18 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 48 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 49 |
Pars Distalis, Hyperplasia | 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 49 |
C-Cell, Hyperplasia | 1 2 2 2 | 38 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 48 |
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 5| 6| 8| 8| | |
DAY ON TEST | 1| 2| 8| 1| 7| 7| | |
| 7| 3| 0| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 1 3 | 3 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
Thrombosis | | 1 2.0|
Endometrium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 49 |
Inflammation, Granulomatous | | 1 2.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Pancreatic, Inflammation, | | |
Granulomatous | | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 42 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 44 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + | 45 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Depletion Cellular | | 1 4.0|
Fibrosis | | 6 2.0|
Hematopoietic Cell Proliferation | | 2 3.0|
Hemorrhage | | 2 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Inflammation, Chronic Active | 4 | 5 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Fibrous Osteodystrophy | | 3 2.7|
Hyperostosis | 4 | 6 3.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 5| 6| 8| 8| | |
DAY ON TEST | 1| 2| 8| 1| 7| 7| | |
| 7| 3| 0| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 47 |
Epiglottis, Metaplasia, Squamous | | 16 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion, Chronic | | 1 3.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 5 1.4|
Alveolar Epithelium, Metaplasia | 1 2 2 2 | 44 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 | 38 1.1|
Artery, Mediastinum, Mineralization | | 1 4.0|
Interstitium, Fibrosis | 1 1 1 1 | 41 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + | 49 |
Inflammation, Suppurative | 2 | 7 2.0|
Thrombosis | | 7 2.3|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 2 1 1 2 3 | 47 1.8|
Lateral Wall, Hyperplasia | 2 1 2 2 2 | 49 1.9|
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 | 25 1.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 | 48 1.8|
Olfactory Epithelium, Metaplasia | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
Cornea, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Mineralization | | 1 2.0|
Nephropathy | 2 2 2 2 4 | 47 2.5|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 8| 6| 5| 6| 8| 8| | |
DAY ON TEST | 1| 2| 8| 1| 7| 7| | |
| 7| 3| 0| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|
| 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 3 2 2 3 |
Degeneration, Fatty | 2 3 2 1 1 2 2 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X X X X X X|
Mixed Cell Focus | X X X X|
Necrosis | 1 2 1 |
Bile Duct, Hyperplasia | 2 2 1 2 1 1 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 2 2 1 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Necrosis | 3 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 1 2 |
Necrosis | 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 2 1 1 1 1 1 1 2 1 2 1 1 2 2|
Artery, Mineralization | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|
| 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 3 2 1 2 2 1 1 1 2 2 2|
Hypertrophy | 1 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 1 2 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + M + + + + M + M + + + + +|
Hyperplasia | 2 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 4 1 1 1 1 2 1 2 1 2|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + M M M M + + M + + + + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|
| 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 |
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 3|
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 1 2 1 1 2 2 3 3 1 3 3 2 2 1 2 1 2 2 3 2 2 2 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 4 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolar Epithelium, Metaplasia | 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Artery, Mediastinum, Mineralization | 4 |
Interstitium, Fibrosis | 2 2 3 3 2 2 3 3 3 2 3 3 2 3 3 2 3 3 2 3 3 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 1 2 2 |
Thrombosis | 2 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 3 2 2 3 2 3 2 2 3 3 2 2 2 3 3 2 3 2 2 3 2 2 2 2|
Lateral Wall, Hyperplasia | 3 3 2 3 2 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 2|
Lateral Wall, Metaplasia, Squamous | 2 3 1 2 1 2 2 1 1 2 1 2 1 2 3 1 2 1 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 4 4 3 3 4 3 3 3 3 3 3 3 2 3 1 3 3 4 4 4 3 3 3 3|
Olfactory Epithelium, Metaplasia | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|
DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|
| 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Nephropathy | 1 2 4 2 3 4 4 1 2 3 4 3 4 3 2 1 2 1 2 1 3 2 3|
Thrombosis | 2 |
Pelvis, Inflammation, Acute | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|
DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|
| 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + I + + + + + I + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 3 2 2 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X X X X |
Necrosis | |
Bile Duct, Hyperplasia | 1 2 2 |
Centrilobular, Necrosis | 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 2 1 2 2 1 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 3 |
Necrosis | 4 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Necrosis | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 1 1 2 1 2 2 1 |
Artery, Mineralization | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|
DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|
| 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 2 1 2 1 1 2 2 2 2 1 |
Hypertrophy | 3 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
Pars Distalis, Hyperplasia | 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + M M M + + M M + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + M + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|
DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|
| 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 1 2 3 2 2 1 3 4 2 3 2 1 2 1 2 4 1 3 2 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolar Epithelium, Metaplasia | 2 3 4 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
Artery, Mediastinum, Mineralization | |
Interstitium, Fibrosis | 2 2 4 2 2 2 3 2 2 3 3 3 2 3 2 3 3 2 1 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 3 |
Thrombosis | 3 3 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 2 2 1 3 2 2 3 2 3 3 3 2 2 2 3 3 2 2 3 3 2|
Lateral Wall, Hyperplasia | 3 3 2 3 2 3 3 3 3 2 2 3 3 3 3 3 3 2 3 3 3|
Lateral Wall, Metaplasia, Squamous | 1 2 2 1 2 2 1 2 2 1 1 1 1 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 4 4 2 3 4 3 3 3 4 4 3 3 3 3 4 4 3 4 3 4 3|
Olfactory Epithelium, Metaplasia | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|
DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|
| 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mineralization | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Nephropathy | 1 1 4 2 2 2 3 3 2 2 3 2 3 3 2 2 1 3 1 2 1|
Thrombosis | |
Pelvis, Inflammation, Acute | 3 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 4| 5| | |
DAY ON TEST | 2| 5| 1| 7| 6| 6| | |
| 3| 1| 3| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 50 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 47 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 50 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | 3 | 3 2.0|
Basophilic Focus | X X X X | 42 |
Clear Cell Focus | | 5 |
Degeneration, Cystic | | 5 2.4|
Degeneration, Fatty | 3 | 11 2.1|
Eosinophilic Focus | | 4 |
Hepatodiaphragmatic Nodule | | 12 |
Mixed Cell Focus | X | 9 |
Necrosis | | 3 1.3|
Bile Duct, Hyperplasia | | 10 1.6|
Centrilobular, Necrosis | | 5 1.4|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | 1 2 | 21 1.5|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Basophilic Focus | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Hyperplasia, Squamous | | 3 3.0|
Necrosis | 3 | 7 2.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Mineralization | | 4 1.8|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 4| 5| | |
DAY ON TEST | 2| 5| 1| 7| 6| 6| | |
| 3| 1| 3| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Cardiomyopathy | 1 1 1 1 | 35 1.4|
Artery, Mineralization | | 1 3.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 50 |
Atrophy | | 1 3.0|
Hyperplasia | | 22 1.6|
Hypertrophy | 1 | 6 1.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 8 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 50 |
Hyperplasia | 1 | 13 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + | 44 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Cyst | | 2 1.0|
Pars Distalis, Hyperplasia | | 10 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
C-Cell, Hyperplasia | 3 1 1 1 | 30 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + | 47 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 4| 5| | |
DAY ON TEST | 2| 5| 1| 7| 6| 6| | |
| 3| 1| 3| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Renal, Infiltration Cellular, Plasma | | |
Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + | 34 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + | 46 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 45 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Fibrosis | | 3 2.0|
Hematopoietic Cell Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 50 |
Galactocele | | 3 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Inflammation, Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Fibrous Osteodystrophy | | 2 2.5|
Hyperostosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Gliosis | | 1 3.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 50 |
Epiglottis, Metaplasia, Squamous | 1 3 1 1 2 | 48 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Inflammation, Chronic Active | | 2 2.5|
Mineralization | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
Alveolar Epithelium, Metaplasia | 3 3 3 3 3 | 50 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 4| 5| | |
DAY ON TEST | 2| 5| 1| 7| 6| 6| | |
| 3| 1| 3| 5| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 1 2 | 49 2.0|
Artery, Mediastinum, Mineralization | | 1 4.0|
Interstitium, Fibrosis | 3 2 3 2 2 | 50 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Inflammation, Suppurative | 1 | 10 1.9|
Thrombosis | | 3 2.7|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 2 3 3 3 3 | 50 2.4|
Lateral Wall, Hyperplasia | 3 3 3 3 3 | 50 2.8|
Lateral Wall, Metaplasia, Squamous | 2 2 | 35 1.6|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 4 3 3 3 | 50 3.2|
Olfactory Epithelium, Metaplasia | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 2.0|
Degeneration | | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Mineralization | | 1 2.0|
Nephropathy | 2 3 4 2 2 | 49 2.3|
Thrombosis | | 1 2.0|
Pelvis, Inflammation, Acute | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|
DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|
| 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 3 2 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 2 1 2 2 2 2 3 2 2 |
Degeneration, Fatty | 2 1 2 2 2 2 1 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Necrosis | |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 1 2 2 3 1 2 1 2 3 3 2 1 1 3 3 3 2 4|
Centrilobular, Necrosis | 3 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Inflammation, Chronic Active | |
Artery, Mineralization | 4 3 3 3 3 |
Fat, Necrosis | 1 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2 2 2 2 2 2 1 4 3 1 2 |
Hyperplasia | 2 2 |
Thrombosis | 2 |
Artery, Inflammation | 4 |
Artery, Mineralization | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Mineralization | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 4 2 3 2 |
Necrosis | 2 2 3 1 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|
DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|
| 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 3 3 3 4 4 3 4 3 |
Necrosis | 3 2 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
Aorta, Mineralization | 3 4 4 4 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 1 3 1 2 1 3 2 3 3 3 1 3 1 3 3 3 3|
Mineralization | |
Artery, Mineralization | 2 3 4 4 3 |
Atrium, Thrombosis | 3 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 2 2 2 2 2 2 1 2 2 |
Hypertrophy | 2 2 1 1 1 |
Vacuolization Cytoplasmic | 2 2 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 3 2 2 2 1 2 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 4 4 4 4 4 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Thrombosis | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 3 1 2 1 1 1 1 1 2 1 2 2 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 3 |
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|
DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|
| 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
Inflammation, Chronic Active | 3 2 3 2 4 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 2 3 4 4 |
Artery, Inflammation, Chronic Active | 2 2 3 |
Artery, Mineralization | 3 |
Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Renal, Hemorrhage | 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + M + + + + + + + M M + + + + + M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 3 2 3 3 |
Hemorrhage | |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M + M + + + + M + + + M + + + + + + M +|
Galactocele | |
Hyperplasia, Atypical | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperkeratosis | 4 3 3 |
Inflammation, Chronic Active | 3 4 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 3 3 4 3 3 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|
DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|
| 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | |
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 |
Mineralization | 2 3 4 4 2 3 |
Necrosis | |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 2 4 |
Artery, Mediastinum, Mineralization | 4 3 4 4 4 |
Artery, Mediastinum, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 2 1 2 2 3 3 |
Thrombosis | 2 4 3 1 2 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 1 |
Lateral Wall, Hyperplasia | 2 2 1 1 2 1 |
Lateral Wall, Metaplasia, Squamous | 2 4 2 4 2 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 2 2 1 1 2 2 2 1 1 2 2 1 2 1 2 1 1 2 2 2|
Olfactory Epithelium, Metaplasia | 1 1 1 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 |
Hyperplasia, Oncocytic | |
Mineralization | 2 2 4 3 4 4 3 |
Nephropathy | 3 4 3 3 3 3 4 3 4 2 4 4 4 4 4 4 4 3 4 2 2 4 4 4|
Pelvis, Dilatation | |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Hyperplasia | 1 3 1 2 |
Renal Tubule, Hyperplasia, Oncocytic | |
Transitional Epithelium, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|
DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|
| 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|
DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|
| 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + +|
Mineralization | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Acute | 3 |
Mineralization | 2 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Acute | 2 |
Mineralization | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 2 1 2 2 2 |
Degeneration, Fatty | 1 2 2 1 1 3 3 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Necrosis | 1 |
Thrombosis | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 1 3 3 3 4 2 2 1 3 2 2 3 1 1 3 1|
Centrilobular, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic Active | 2 |
Artery, Mineralization | 2 |
Fat, Necrosis | 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2 3 1 2 2 3 1 2 |
Hyperplasia | 2 |
Thrombosis | |
Artery, Inflammation | |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Artery, Mineralization | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Necrosis | 2 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|
DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|
| 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 3 3 3 3 |
Necrosis | 2 3 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Aorta, Mineralization | 3 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 3 2 2 1 2 2 3 2 3 2 2 3 2 2 2 |
Mineralization | 2 |
Artery, Mineralization | 3 3 3 |
Atrium, Thrombosis | 3 3 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 1 2 2 2 2 2 1 2|
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 1 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 2 3 4 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Thrombosis | 3 |
Pars Distalis, Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 4 2 3 1 1 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|
DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|
| 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Artery, Inflammation, Chronic Active | 3 |
Artery, Mineralization | |
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M M + + M + + + + M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 3 4 2 3 |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + + + + + M + M M M M M M|
Galactocele | 2 2 3 |
Hyperplasia, Atypical | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 2 4 3 4 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 3 2 4 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|
DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|
| 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | 4 |
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 2 |
Mineralization | 2 3 2 2 |
Necrosis | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 1 |
Artery, Mediastinum, Mineralization | 3 4 |
Artery, Mediastinum, Thrombosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 3 2 |
Thrombosis | 3 2 4 3 1 1 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | |
Lateral Wall, Hyperplasia | 2 1 2 1 |
Lateral Wall, Metaplasia, Squamous | 3 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 2 1 2 2 1 1 1 2 2 1 2 2 1 1 2 2|
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Oncocytic | 2 |
Mineralization | 2 3 2 |
Nephropathy | 3 4 4 2 3 4 3 3 3 4 4 4 4 3 4 4 2 2 2 2 3|
Pelvis, Dilatation | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Hyperplasia | 3 1 |
Renal Tubule, Hyperplasia, Oncocytic | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|
DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|
| 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 7| | |
DAY ON TEST | 3| 2| 4| 8| 2| 9| | |
| 6| 1| 4| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 49 |
Mineralization | | 5 2.4|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 49 |
Inflammation, Acute | | 1 3.0|
Mineralization | | 2 2.0|
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 49 |
Inflammation, Acute | | 1 2.0|
Mineralization | | 3 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + | 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | X | 23 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 2 | 15 1.9|
Degeneration, Fatty | | 14 1.8|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 3 |
Mixed Cell Focus | X | 3 |
Necrosis | | 1 1.0|
Thrombosis | 1 | 2 1.5|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 3 3 2 3 | 39 2.2|
Centrilobular, Necrosis | 2 | 7 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 16 |
Inflammation, Chronic Active | | 1 2.0|
Artery, Mineralization | | 6 3.0|
Fat, Necrosis | 2 | 8 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 50 |
Atrophy | 2 2 2 | 28 2.2|
Hyperplasia | | 3 2.0|
Thrombosis | | 1 2.0|
Artery, Inflammation | | 1 4.0|
Artery, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 7| | |
DAY ON TEST | 3| 2| 4| 8| 2| 9| | |
| 6| 1| 4| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 50 |
Mineralization | | 7 2.6|
Necrosis | | 9 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 50 |
Mineralization | | 13 3.2|
Necrosis | | 6 2.2|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 9 |
Aorta, Mineralization | | 9 3.8|
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Cardiomyopathy | 2 3 | 40 2.2|
Mineralization | | 1 2.0|
Artery, Mineralization | | 8 3.1|
Atrium, Thrombosis | | 7 2.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 50 |
Atrophy | | 1 3.0|
Hyperplasia | | 18 1.8|
Hypertrophy | 1 | 7 1.3|
Vacuolization Cytoplasmic | | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 50 |
Hyperplasia | 3 2 | 21 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 50 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 49 |
Hyperplasia | 2 | 15 3.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 50 |
Mineralization | | 1 2.0|
Thrombosis | | 1 3.0|
Pars Distalis, Hyperplasia | 3 3 | 7 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 50 |
C-Cell, Hyperplasia | 1 1 | 28 1.5|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 7| | |
DAY ON TEST | 3| 2| 4| 8| 2| 9| | |
| 6| 1| 4| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 50 |
Granuloma Sperm | | 2 2.5|
__________________________________________________________________________|____________|
Penis | | 4 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 50 |
Inflammation, Chronic Active | | 5 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + | 50 |
Hyperplasia | | 6 2.2|
Inflammation, Chronic Active | 1 4 | 10 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 3 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + | 50 |
Atrophy | 2 | 9 3.0|
Artery, Inflammation, Chronic Active | | 4 2.5|
Artery, Mineralization | | 1 3.0|
Interstitial Cell, Hyperplasia | 2 | 10 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 20 |
Renal, Hemorrhage | | 7 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M | 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 48 |
Infiltration Cellular, Plasma Cell | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 49 |
Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + | 45 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 50 |
Fibrosis | 2 3 | 16 2.7|
Hemorrhage | 4 | 1 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + | 31 |
Galactocele | 3 | 4 2.5|
Hyperplasia, Atypical | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 7| | |
DAY ON TEST | 3| 2| 4| 8| 2| 9| | |
| 6| 1| 4| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 50 |
Fibrosis | | 1 3.0|
Hyperkeratosis | | 4 3.0|
Inflammation, Chronic Active | 3 3 | 16 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
Fibrous Osteodystrophy | | 15 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Pigmentation, Hemosiderin | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 50 |
Mineralization | | 5 2.4|
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion, Chronic | | 1 4.0|
Hemorrhage | | 2 3.0|
Inflammation, Chronic Active | | 3 1.3|
Mineralization | | 10 2.7|
Necrosis | | 1 3.0|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 4 2.3|
Artery, Mediastinum, Mineralization | | 7 3.7|
Artery, Mediastinum, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 50 |
Inflammation, Suppurative | 2 | 14 2.4|
Thrombosis | | 11 2.4|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | | 1 1.0|
Lateral Wall, Hyperplasia | | 10 1.5|
Lateral Wall, Metaplasia, Squamous | 1 1 | 10 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 2 2 2 | 49 1.6|
Olfactory Epithelium, Metaplasia | | 5 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 5| 6| 7| | |
DAY ON TEST | 3| 2| 4| 8| 2| 9| | |
| 6| 1| 4| 0| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| | A |
CONTROL | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mineralization | | 3 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 50 |
Cyst | | 3 2.7|
Hyperplasia, Oncocytic | | 1 2.0|
Mineralization | | 10 2.9|
Nephropathy | 3 2 2 2 2 | 50 3.2|
Pelvis, Dilatation | 2 | 1 2.0|
Pelvis, Inflammation, Acute | | 1 2.0|
Renal Tubule, Hyperplasia | | 6 1.8|
Renal Tubule, Hyperplasia, Oncocytic | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 50 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic Active | | 2 2.5|
Transitional Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|
DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|
| 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
Parasite Metazoan | X |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X |
Degeneration, Cystic | 2 2 4 2 2 |
Degeneration, Fatty | 2 1 2 2 2 3 2 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Mixed Cell | |
Mixed Cell Focus | X X |
Necrosis | 2 3 2 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 4 1 3 1 1 1 2 2 3 2 2 1 2 1 3 3 |
Centrilobular, Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Artery, Inflammation, Chronic Active | 4 |
Artery, Mineralization | 3 3 |
Fat, Necrosis | 2 2 2 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 1 1 2 1 1 2 1 3 3 2 2 1 4 |
Basophilic Focus | |
Hyperplasia | 2 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + |
Diverticulum | X |
Hyperplasia, Squamous | 3 |
Mineralization | 1 2 |
Necrosis | 4 3 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Mineralization | 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|
DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|
| 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Aorta, Mineralization | 4 1 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 1 2 2 3 1 3 2 2 3 2 1 1 2 3 2 2 2 2 2 |
Inflammation, Chronic Active | |
Artery, Mineralization | 3 1 1 3 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
Hyperplasia | 2 1 2 2 2 2 1 1 2 1 |
Hypertrophy | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 2 2 1 3 1 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 4 2 2 4 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + |
Thrombosis | 4 |
Pars Distalis, Hyperplasia | 4 2 3 |
Pars Distalis, Necrosis | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + M + + + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|
DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|
| 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 4 3 |
Artery, Inflammation, Chronic Active | 3 2 2 |
Interstitial Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Hemorrhage | 1 |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M + + M + + + M M + + M + + M + + M |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + M + |
Hemorrhage | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 3 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + + + + + M + + M + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M I + M M M M + + + + M + M + M M M + + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 4 |
Prepuce, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 3 1 3 2 |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|
DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|
| 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + A + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 1 |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + |
Congestion, Chronic | |
Foreign Body | |
Hemorrhage | |
Inflammation, Suppurative | |
Mineralization | 3 1 3 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolar Epithelium, Metaplasia | 2 2 1 2 2 2 2 2 3 2 2 2 1 2 2 2 2 2 1 2 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Artery, Mediastinum, Mineralization | |
Interstitium, Fibrosis | 2 1 1 2 2 2 2 2 2 2 2 1 1 2 1 2 2 1 1 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 2 2 2 1 2 2 1 |
Thrombosis | 2 1 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 2 1 1 2 2 1 1 1 2 2 1 1 2 1 1 1 2 2 2 2 2 1 1 |
Lateral Wall, Hyperplasia | 2 2 1 2 2 1 2 2 2 1 3 2 1 3 2 1 1 2 1 3 2 3 2 1 |
Lateral Wall, Metaplasia, Squamous | 3 2 2 2 1 1 1 3 3 2 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 1 1 1 1 2 1 |
Olfactory Epithelium, Metaplasia | 2 |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Degeneration | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Mineralization | 2 2 3 |
Nephropathy | 4 4 1 3 3 3 4 4 4 3 3 4 4 2 3 2 2 4 2 3 2 4 1 4 |
Renal Tubule, Hyperplasia | 2 2 2 |
Renal Tubule, Hyperplasia, Oncocytic | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|
DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|
| 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|
| 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X X X |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 |
Basophilic Focus | X X X X X X X X |
Degeneration, Cystic | 3 2 2 3 2 2 |
Degeneration, Fatty | 3 3 3|
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Mixed Cell | 3 |
Mixed Cell Focus | |
Necrosis | 3 |
Vacuolization Cytoplasmic, Focal | 1 3 |
Bile Duct, Hyperplasia | 1 3 1 1 2 1 2 1 2 2 3 1 1 1 2 2 2|
Centrilobular, Necrosis | 4 2 2 2 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Artery, Inflammation, Chronic Active | |
Artery, Mineralization | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 1 2 2 2 3 2 2 1 2 2|
Basophilic Focus | X |
Hyperplasia | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | |
Mineralization | |
Necrosis | 3 1 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mineralization | 3 3 1 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|
| 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 2 2 3 1 2 2 3 1 1 2 3 2 2|
Inflammation, Chronic Active | 4 |
Artery, Mineralization | 2 2 |
Atrium, Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 1 2 2 3 1 2 2 1|
Hypertrophy | 1 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Pars Distalis, Hyperplasia | 2 1 2 3 |
Pars Distalis, Necrosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 2 1 1 1 1 1 1 2 2 1|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 4 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|
| 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 |
Artery, Inflammation, Chronic Active | |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Lumbar, Hemorrhage | |
Renal, Hemorrhage | 2 2 |
Renal, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M + M + + + + + + + + + M +|
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M + + M M M M M + M + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Prepuce, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 3 2 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|
| 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + +|
Mineralization | |
Epiglottis, Metaplasia, Squamous | 1 3 2 1 1 1 1 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion, Chronic | 3 |
Foreign Body | X |
Hemorrhage | 3 |
Inflammation, Suppurative | 4 |
Mineralization | 1 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1|
Artery, Mediastinum, Mineralization | 3 |
Interstitium, Fibrosis | 1 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 2 2 2 |
Thrombosis | 3 4 2 3 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 1 1 1 1 1 1 1 2 2 2 2 1 2 3 2 1 2 1|
Lateral Wall, Hyperplasia | 2 2 1 1 1 1 1 3 1 2 2 2 3 3 2 2 3 2|
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 3 3 1|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 2 1 1 2 2 1 2 2 1 2 2 2 2 3 2|
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Degeneration | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Mineralization | 1 2 |
Nephropathy | 4 2 2 4 4 4 2 2 2 2 4 2 3 3 2 2 4 2 3|
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Hyperplasia, Oncocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|
DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|
| 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 3| 6| 6| | |
DAY ON TEST | 1| 9| 2| 4| 7| 6| | |
| 1| 5| 2| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
Parasite Metazoan | X | 5 |
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 48 |
Inflammation, Acute | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Angiectasis | 2 | 6 2.0|
Basophilic Focus | X | 18 |
Degeneration, Cystic | 1 2 | 13 2.2|
Degeneration, Fatty | 3 1 | 13 2.2|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X | 2 |
Infiltration Cellular, Mixed Cell | | 1 3.0|
Mixed Cell Focus | | 2 |
Necrosis | | 4 2.5|
Vacuolization Cytoplasmic, Focal | | 2 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 | 38 1.8|
Centrilobular, Necrosis | 1 | 10 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 17 |
Artery, Inflammation, Chronic Active | | 1 4.0|
Artery, Mineralization | | 3 3.0|
Fat, Necrosis | 2 2 | 10 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Atrophy | 2 | 28 2.0|
Basophilic Focus | | 1 |
Hyperplasia | | 3 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Diverticulum | | 1 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 3| 6| 6| | |
DAY ON TEST | 1| 9| 2| 4| 7| 6| | |
| 1| 5| 2| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 2 1.5|
Necrosis | 4 3 4 | 10 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Mineralization | 2 | 7 2.7|
Necrosis | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 4 |
Aorta, Mineralization | | 4 2.8|
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | 3 1 2 2 2 | 44 2.0|
Inflammation, Chronic Active | | 1 4.0|
Artery, Mineralization | | 6 2.0|
Atrium, Thrombosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 49 |
Atrophy | 4 | 2 3.5|
Hyperplasia | 2 1 1 | 22 1.6|
Hypertrophy | 2 2 | 5 1.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 49 |
Hyperplasia | 2 2 1 | 19 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Hyperplasia | | 4 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 50 |
Hyperplasia | 3 | 10 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + | 48 |
Thrombosis | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 | 9 2.4|
Pars Distalis, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Hyperplasia | 2 1 | 29 1.2|
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 3| 6| 6| | |
DAY ON TEST | 1| 9| 2| 4| 7| 6| | |
| 1| 5| 2| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 4 |
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 48 |
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | | 3 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 50 |
Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Atrophy | | 5 3.2|
Artery, Inflammation, Chronic Active | | 3 2.3|
Interstitial Cell, Hyperplasia | | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 13 |
Lumbar, Hemorrhage | | 1 1.0|
Renal, Hemorrhage | 2 | 4 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 37 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 47 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + | 48 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Fibrosis | 2 | 6 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 1 3.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + M M | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + M | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 3| 6| 6| | |
DAY ON TEST | 1| 9| 2| 4| 7| 6| | |
| 1| 5| 2| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Inflammation, Chronic Active | | 3 2.7|
Prepuce, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Fibrous Osteodystrophy | 1 | 8 2.0|
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Mineralization | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 48 |
Mineralization | | 1 1.0|
Epiglottis, Metaplasia, Squamous | 2 | 20 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Congestion, Chronic | | 1 3.0|
Foreign Body | | 1 |
Hemorrhage | 1 | 2 2.0|
Inflammation, Suppurative | | 1 4.0|
Mineralization | | 6 1.8|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
Alveolar Epithelium, Metaplasia | 1 2 2 2 2 | 45 1.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 | 38 1.2|
Artery, Mediastinum, Mineralization | | 1 3.0|
Interstitium, Fibrosis | 1 2 2 1 1 | 44 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Inflammation, Suppurative | 1 | 13 1.8|
Thrombosis | | 6 2.5|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 1 2 2 2 1 | 46 1.5|
Lateral Wall, Hyperplasia | 2 2 2 2 2 2 | 48 1.9|
Lateral Wall, Metaplasia, Squamous | 1 1 1 | 23 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 3| 6| 6| | |
DAY ON TEST | 1| 9| 2| 4| 7| 6| | |
| 1| 5| 2| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| | A |
0.5 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 2 2 | 49 1.7|
Olfactory Epithelium, Metaplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Degeneration | | 1 3.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Cyst | | 3 2.0|
Mineralization | | 5 2.0|
Nephropathy | 2 4 3 3 3 3 | 49 2.9|
Renal Tubule, Hyperplasia | | 4 2.0|
Renal Tubule, Hyperplasia, Oncocytic | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|
| 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X X X X X X X X X X X|
Degeneration, Cystic | 3 3 1 2 |
Degeneration, Fatty | 1 1 1 3|
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | |
Necrosis | 1 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 3 3 2 3 2 2 2 2 1 3 2 2 3 2 |
Centrilobular, Necrosis | 2 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 2 2 3 1 2 2 2 2 3 1|
Basophilic Focus | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Hyperplasia, Squamous | |
Necrosis | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 3|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + +|
Aorta, Mineralization | 3 2|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|
| 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 2 2 2 3 2 1 1 1 3|
Artery, Mineralization | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1 2 1 2 2 2|
Hypertrophy | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 2 |
Pars Distalis, Hyperplasia | 2 3 4 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Artery, Inflammation, Chronic Active | 3 |
Interstitial Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|
| 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + M + + + M + + M + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M|
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 2 3 |
Hemorrhage | 4 |
Necrosis | 4 4 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + + + M M + + M + + + + M M M + M + +|
Galactocele | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + I + + + + +|
Cyst | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | |
Necrosis | |
Meninges, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + +|
Epiglottis, Metaplasia, Squamous | 3 1 1 2 3 1 1 2 2 1 2 1 1 1 2 2 2 1 2|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
Mineralization | 4 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|
| 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Metaplasia | 4 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 2 1 3 3 3|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1 1 2 2 2|
Artery, Mediastinum, Mineralization | 3 |
Interstitium, Fibrosis | 3 2 2 2 2 3 2 2 2 2 2 2 3 2 3 3 3 2 1 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 1 1 3 2|
Thrombosis | 2 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 3 2 3 2 3 3 3 3 3 3 3 2 3 2 2 3 2 2 3 2 3|
Lateral Wall, Hyperplasia | 3 3 3 3 3 3 2 3 3 3 3 3 3 3 2 3 3 3 3 2 3|
Lateral Wall, Metaplasia, Squamous | 1 2 2 2 1 4 1 1 3 3 2 3 2 1 2 2 3 3|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 4 3 2 3 2 3 3 3 3 3 4 3 3 3 3 3 2 3 3 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | |
Degeneration | 3|
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2|
Mineralization | 2 2|
Nephropathy | 1 3 4 3 2 4 3 2 3 2 4 2 4 3 3 3 2 2 2 3 4 4|
Renal Tubule, Hyperplasia | 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | 2|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|
| 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + |
Inflammation, Acute | 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + A + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + A + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X |
Degeneration, Cystic | 3 1 2 2 2 2 2 2 2 2 |
Degeneration, Fatty | 2 3 2 2 1 |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Necrosis | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 1 3 1 2 1 2 2 2 3 |
Centrilobular, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Hemorrhage | 3 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Hyperplasia, Squamous | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 3 2 1 2 4 2 2 3 1 2 |
Basophilic Focus | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Diverticulum | X |
Hyperplasia, Squamous | 3 3 |
Necrosis | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 3 1 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 2 3 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|
| 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 1 2 1 3 1 3 3 2 3 2 2 2 2 2 |
Artery, Mineralization | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 2 2 2 2 2 1 2 2 2 2 |
Hypertrophy | |
Necrosis | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 2 2 3 4 3 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 4 |
Mineralization | |
Pars Distalis, Hyperplasia | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + |
Granuloma Sperm | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 1 3 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Artery, Inflammation, Chronic Active | 3 1 |
Interstitial Cell, Hyperplasia | 3 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|
| 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Infiltration Cellular, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + M M M M M M + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + + + |
Hemorrhage | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 2 2 2 2 3 2 |
Hemorrhage | 3 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + M + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + M M M M + M M + + + M M + M + + |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Inflammation, Chronic Active | 3 3 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 2 3 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 2 |
Mineralization | 1 |
Necrosis | 2 |
Meninges, Hyperplasia | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + I + + + + + + + + + + + + + + + + + + + + |
Epiglottis, Metaplasia, Squamous | 1 1 1 2 2 1 1 3 2 3 2 1 2 3 2 2 2 3 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 2 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
Mineralization | 3 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
_____________________________________________________________________________________________________________________
| 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|
DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|
| 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 2 3 2 |
Alveolar Epithelium, Metaplasia | 3 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 |
Artery, Mediastinum, Mineralization | |
Interstitium, Fibrosis | 3 1 2 2 3 3 2 2 2 3 2 2 3 3 3 2 3 2 3 3 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + + + + + |
Inflammation, Suppurative | 3 1 2 2 2 2 3 2 2 2 |
Thrombosis | 2 1 |
Goblet Cell, Lateral Wall, | |
Hyperplasia | 2 3 3 2 3 2 3 3 3 3 3 3 3 3 2 2 1 3 3 2 3 |
Lateral Wall, Hyperplasia | 2 2 2 3 3 3 2 2 3 3 3 3 3 3 2 2 3 3 3 3 |
Lateral Wall, Metaplasia, Squamous | 3 3 3 3 1 2 3 2 2 2 3 3 3 2 3 3 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 3 3 2 3 3 3 2 2 2 3 3 3 2 3 4 3 3 3 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 4 |
Degeneration | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Mineralization | |
Nephropathy | 4 3 2 4 4 4 2 2 2 4 3 2 2 3 4 2 4 4 2 3 4 4 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + |
Infiltration Cellular, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 7| | |
DAY ON TEST | 2| 1| 5| 6| 8| 0| | |
| 1| 9| 3| 1| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 49 |
Inflammation, Acute | | 1 2.0|
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Angiectasis | | 3 2.0|
Basophilic Focus | X X | 23 |
Degeneration, Cystic | 2 3 | 16 2.1|
Degeneration, Fatty | | 9 1.8|
Eosinophilic Focus | | 5 |
Hepatodiaphragmatic Nodule | X | 6 |
Mixed Cell Focus | | 1 |
Necrosis | 1 | 3 1.3|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 3 3 | 29 2.1|
Centrilobular, Necrosis | 2 | 6 1.7|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Hemorrhage | | 1 3.0|
Fat, Necrosis | | 4 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 4 |
Gingival, Hyperplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Atrophy | 2 1 2 3 | 28 2.0|
Basophilic Focus | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Duct, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Diverticulum | | 1 |
Hyperplasia, Squamous | | 2 3.0|
Necrosis | 2 | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Mineralization | | 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 7| | |
DAY ON TEST | 2| 1| 5| 6| 8| 0| | |
| 1| 9| 3| 1| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 4 |
Aorta, Mineralization | | 4 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | 3 1 1 1 3 | 39 1.9|
Artery, Mineralization | | 2 2.5|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 50 |
Hyperplasia | 2 2 1 | 25 1.7|
Hypertrophy | | 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 50 |
Hyperplasia | 1 1 2 | 15 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 50 |
Hyperplasia | 2 | 12 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Hemorrhage | | 1 4.0|
Mineralization | | 1 2.0|
Pars Distalis, Hyperplasia | 3 | 8 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Hyperplasia | 1 2 1 1 1 | 22 1.1|
Follicular Cell, Hyperplasia | | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 50 |
Inflammation, Chronic Active | | 6 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 7| | |
DAY ON TEST | 2| 1| 5| 6| 8| 0| | |
| 1| 9| 3| 1| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Hyperplasia | | 4 2.3|
Inflammation, Chronic Active | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Atrophy | | 1 4.0|
Artery, Inflammation, Chronic Active | | 3 2.3|
Interstitial Cell, Hyperplasia | 2 | 10 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 13 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M M + | 36 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 47 |
Hemorrhage | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 47 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Fibrosis | 2 | 13 2.2|
Hemorrhage | | 3 3.3|
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M + + | 26 |
Galactocele | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 49 |
Cyst | | 1 2.0|
Inflammation, Chronic Active | 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Fibrous Osteodystrophy | | 5 2.2|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 7| | |
DAY ON TEST | 2| 1| 5| 6| 8| 0| | |
| 1| 9| 3| 1| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Hemorrhage | | 2 2.0|
Mineralization | | 1 1.0|
Necrosis | | 1 2.0|
Meninges, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | A + I + + + | 47 |
Epiglottis, Metaplasia, Squamous | 3 2 1 2 | 43 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Hemorrhage | 1 | 3 1.3|
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | | 4 2.8|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 4 | 6 2.3|
Alveolar Epithelium, Metaplasia | 3 2 3 3 3 3 | 50 2.9|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 2 2 2 | 49 1.9|
Artery, Mediastinum, Mineralization | | 1 3.0|
Interstitium, Fibrosis | 2 2 2 3 2 2 | 50 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Inflammation, Suppurative | 3 | 18 2.0|
Thrombosis | | 3 1.7|
Goblet Cell, Lateral Wall, | | |
Hyperplasia | 3 3 2 3 3 3 | 48 2.6|
Lateral Wall, Hyperplasia | 2 3 3 3 3 3 | 47 2.8|
Lateral Wall, Metaplasia, Squamous | 1 1 2 3 3 | 40 2.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 3 3 3 3 3 3 | 49 2.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 2 3.5|
Degeneration | | 2 3.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 4| 7| | |
DAY ON TEST | 2| 1| 5| 6| 8| 0| | |
| 1| 9| 3| 1| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| | A |
1.0 PPM | 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Cyst | | 3 2.0|
Mineralization | | 2 2.0|
Nephropathy | 2 2 3 4 3 3 | 50 3.0|
Renal Tubule, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 49 |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
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---------- END OF REPORT ----------
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