TDMS Study 88034-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest DATE: 05/08/95 EXP: 88034 OZONE TIME: 21:57:43 TEST: 05 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC 30-MONTH ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 88034B CONT: N01-ES-95239 CAS: 10028-15-6 PATHOLOGIST: S. GRUMBEIN -------------------------------------------------------------------------------- REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest DATE: 05/08/95 EXP: 88034 OZONE TIME: 21:57:43 TEST: 05 CAGES FROM 0000 TO LAST CAGE TEST TYPE: CHRONIC 30-MONTH ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 88034B CONT: N01-ES-95239 CAS: 10028-15-6 PATHOLOGIST: S. GRUMBEIN OZONE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 874 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 56 UNCENSORED DEATHS 50 CENSORED DEATHS 6 TERMINAL 0 | | | | UNCENSORED DEATHS | | 467 468 481 484 485 521 539 544 580 580 | | 580 583 585 585 586 591 591 598 599 600 | | 610 615 621 625 632 636 651 661 663 663 | | 663 666 669 670 674 674 681 683 691 705 | | 705 708 718 722 733 761 766 793 797 830 | | CENSORED DEATHS | | 623 623 623 623 623 623 | | | |--------------------------------------------------------------------------------| | DOSE = 0.5 PPM | | --------------------- | | | | TOTAL 56 UNCENSORED DEATHS 50 CENSORED DEATHS 6 TERMINAL 0 | | | | UNCENSORED DEATHS | | 219 345 346 384 401 411 419 433 439 495 | | 515 516 521 524 525 531 548 571 581 581 | | 586 601 605 607 608 621 623 628 636 642 | | 648 650 663 666 670 674 681 684 695 699 | | 701 705 719 719 722 733 735 755 775 847 | | CENSORED DEATHS | | 623 623 623 623 623 623 | | | |--------------------------------------------------------------------------------| | DOSE = 1.0 PPM | | --------------------- | | | | TOTAL 56 UNCENSORED DEATHS 49 CENSORED DEATHS 6 TERMINAL 1 | | | | UNCENSORED DEATHS | | 342 383 419 453 488 524 536 539 549 557 | | 567 569 579 581 608 614 616 618 619 621 | | 632 643 650 653 663 666 671 691 701 705 | | 705 708 716 728 728 737 737 741 747 751 | | 754 756 756 760 761 761 779 817 825 | | CENSORED DEATHS | | 623 623 623 623 623 623 | | | ================================================================================== OZONE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 874 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 874 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 100.0 100.0 100.0 100.0 100.0 91.1 85.7 64.3 41.5 0.0 | | | | | | | |0.5 PPM | 100.0 100.0 98.2 94.6 87.5 83.9 71.4 58.9 38.3 0.0 | | | | | | | |1.0 PPM | 100.0 100.0 100.0 98.2 94.6 92.9 85.7 75.0 53.6 2.1 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 0.5 PPM 1.0 PPM | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 0.0% 0.0% 2.1% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.124N P=0.565 P=0.175N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 634.7 592.1 647.4 | |NATURAL DEATHS (C) | (12.2) (18.2) (15.9) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 633.4 595.4 648.9 | |(STANDARD ERROR) | (10.9) (16.3) (14.5) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) OZONE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 874 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 56 UNCENSORED DEATHS 44 CENSORED DEATHS 6 TERMINAL 6 | | | | UNCENSORED DEATHS | | 31 406 417 434 467 494 554 556 557 566 | | 577 581 581 604 627 631 635 635 646 649 | | 652 659 678 684 691 691 696 708 718 719 | | 722 723 731 731 747 747 748 758 760 783 | | 789 790 827 842 | | CENSORED DEATHS | | 623 623 623 623 623 623 | | | |--------------------------------------------------------------------------------| | DOSE = 0.5 PPM | | --------------------- | | | | TOTAL 56 UNCENSORED DEATHS 44 CENSORED DEATHS 6 TERMINAL 6 | | | | UNCENSORED DEATHS | | 287 452 468 509 513 571 579 580 585 598 | | 616 636 636 678 682 691 699 710 721 723 | | 733 733 738 739 756 756 767 775 775 778 | | 793 803 803 810 817 817 824 827 830 838 | | 842 842 849 859 | | CENSORED DEATHS | | 623 623 623 623 623 623 | | | |--------------------------------------------------------------------------------| | DOSE = 1.0 PPM | | --------------------- | | | | TOTAL 56 UNCENSORED DEATHS 43 CENSORED DEATHS 6 TERMINAL 7 | | | | UNCENSORED DEATHS | | 285 467 483 486 536 551 554 559 566 580 | | 614 632 635 643 663 666 670 670 673 682 | | 685 695 699 705 705 713 714 721 733 733 | | 744 753 758 761 775 775 793 800 811 817 | | 831 848 861 | | CENSORED DEATHS | | 623 623 623 623 623 623 | | | ================================================================================== OZONE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 874 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 874 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 98.2 98.2 98.2 98.2 94.6 91.1 89.3 75.0 58.3 12.5 | | | | | | | |0.5 PPM | 100.0 100.0 100.0 98.2 98.2 94.6 91.1 82.1 76.2 12.4 | | | | | | | |1.0 PPM | 100.0 100.0 100.0 98.2 98.2 94.6 91.1 82.1 72.1 14.4 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 0.5 PPM 1.0 PPM | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 12.5% 12.4% 14.4% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.406N P=0.126N P=0.441N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 641.9 705.4 675.5 | |NATURAL DEATHS (C) | (21.5) (19.2) (17.9) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 664.7 714.6 694.7 | |(STANDARD ERROR) | (19.5) (17.2) (16.6) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) OZONE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 0.5 PPM = 2 1.0 PPM = 3 ------------------------------------------------------ SPECIES=RATS SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 3 1 | 2 32 3 3 1 1 | 2 2 3 3 11 | 2 2 3 3 90 + 22 1 1 1 | 2 2 11 | 2 2 313 1 | 2 2 33 80 + 311 | 2 3 | 3 3 | 22 2 1133 P 70 + 2 2 1133 E | 2 R | 22 1133 C | 2 2 33 E 60 + 211133 N | 1 33 T | 2 2 3 | 21 133 S 50 + 2 113 3 U | 22 3 3 R | 22 V | 11 I 40 + 22 33 V | 22 33 A | 11 L | 22 3 3 30 + 11 | 22 | 1 1 3 | 22 33 20 + 11 | 21 | 11 33 | 211 10 + 1 1 | 2 2113 1 3 | 2 2 33 | 2 1 1 2 3 0 + 1 2 | ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+-- 0 20 40 60 80 100 120 140 WEEK NOTE: 41 obs hidden. OZONE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 0.5 PPM = 2 1.0 PPM = 3 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 1 2 | 1 2 11 22 3 | 1 1 2 33 2 | 1 1 3 22 3 90 + 1 1 2 331 2 | | 1122 2 | 11 22 80 + 2 2 | 1 1 P | 1 13 3 22 E | 1 33 2 R 70 + 22 C | 1 1 2 2 E | 333 22 N | 11 22 T 60 + 1 33 | 1 11 22 S | 133 U | 33 22 R 50 + 11 2 2 V | 1 1 2 I | 1 3 V | 11 22 A 40 + 333 2 2 L | 11 33 | 22 | 11 33 22 30 + 3 3 22 | 1 1 3 2 | 33 | 1 1 3322 20 + 11 3322 | 1 1 22 | 1 12 3 | 12 1 10 + | ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+-- 0 20 40 60 80 100 120 140 WEEK NOTE: 51 obs hidden.