TDMS Study 88034-07 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) OZONE/NNK NTP Experiment-Test: 88034-07 Report: PEIRPT03 Study Type: CHRONIC Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 02/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 48 48 48 48 48 48 Early Deaths Moribund Sacrifice 36 40 36 38 36 41 Natural Death 4 2 9 4 7 3 Survivors Terminal Sacrifice 8 6 3 6 5 4 Animals Examined Microscopically 48 48 48 48 48 48 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (1) (1) (1) Mineralization 1 (100%) 1 (100%) Lymphoid Tissue, Hyperplasia, Lymphoid 1 (100%) Intestine Large, Rectum (1) (1) Mineralization 1 (100%) Intestine Large, Cecum (1) (1) (2) (1) Ulcer 1 (50%) 1 (100%) Intestine Small, Ileum (1) (1) (1) (1) Hyperplasia, Lymphoid 1 (100%) Peyer's Patch, Hyperplasia, Lymphoid 1 (100%) Liver (26) (27) (28) (36) (42) (39) Angiectasis 1 (4%) 3 (11%) 3 (8%) 5 (12%) Degeneration, Cystic 5 (19%) 3 (11%) 4 (14%) 8 (22%) 17 (40%) 7 (18%) Hepatodiaphragmatic Nodule 4 (15%) 2 (7%) 1 (4%) 3 (8%) 5 (12%) 1 (3%) Hyperplasia 2 (5%) Hyperplasia, Focal 1 (4%) 1 (4%) 1 (4%) 7 (17%) 4 (10%) Infiltration Cellular, Mixed Cell 1 (4%) 1 (2%) Inflammation 1 (3%) Necrosis 1 (4%) Necrosis, Focal 1 (4%) 3 (7%) 3 (8%) Vacuolization Cytoplasmic 1 (4%) 4 (15%) 4 (14%) 4 (11%) 2 (5%) 2 (5%) Vacuolization Cytoplasmic, Focal 1 (4%) 1 (4%) 1 (2%) Bile Duct, Hyperplasia 1 (4%) 2 (7%) 1 (4%) 1 (2%) Centrilobular, Necrosis 1 (4%) 1 (2%) Mesentery (8) (10) (8) (11) (8) (8) Fat, Necrosis 7 (88%) 9 (90%) 5 (63%) 7 (64%) 8 (100%) 6 (75%) Oral Mucosa (4) (1) Pharyngeal, Foreign Body 1 (100%) Pharyngeal, Hyperplasia, Squamous 2 (50%) Pancreas (1) (1) (1) Artery, Inflammation, Chronic 1 (100%) Stomach, Forestomach (1) (2) (1) (2) (1) Hyperplasia, Squamous 2 (100%) Inflammation, Chronic Active 1 (100%) 1 (50%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Mineralization 1 (100%) 1 (50%) Ulcer 1 (50%) Stomach, Glandular (1) (1) (3) (1) (3) Inflammation, Chronic Active 1 (100%) Mineralization 1 (100%) 2 (67%) Necrosis 1 (33%) 1 (33%) Tooth (1) (1) Developmental Malformation 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (2) (1) Inflammation, Chronic 1 (100%) Mineralization 1 (100%) Aorta, Mineralization 2 (100%) Heart (1) (1) (1) (2) (2) Cardiomyopathy 1 (100%) Fibrosis 1 (50%) Mineralization 1 (100%) Necrosis 1 (100%) Atrium, Thrombosis 1 (50%) Pericardium, Fibrosis 1 (50%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (4) (1) (3) (1) (4) Angiectasis 1 (33%) Vacuolization Cytoplasmic 1 (25%) Adrenal Medulla (4) (1) (1) Hemorrhage 1 (25%) Parathyroid Gland (2) (1) (1) (1) Hyperplasia 2 (100%) 1 (100%) 1 (100%) 1 (100%) Pituitary Gland (34) (35) (29) (27) (30) (34) Pars Distalis, Hemorrhage 1 (3%) Pars Distalis, Hyperplasia 1 (3%) 1 (3%) 2 (7%) 2 (6%) Thyroid Gland (3) (2) (1) (1) (1) Follicular Cell, Hyperplasia 1 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (32) (24) (30) (31) (26) (32) Inflammation, Chronic 30 (94%) 24 (100%) 30 (100%) 30 (97%) 26 (100%) 32 (100%) Tissue NOS (1) (5) (1) Mediastinum, Inflammation, Chronic Active, a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - CONT Diffuse 1 (20%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (1) (1) Granuloma Sperm 1 (100%) Penis (4) (3) (1) (2) (5) Calculus Gross Observation 1 (33%) Calculus Micro Observation Only 1 (33%) 1 (100%) Edema 2 (100%) Inflammation, Chronic Active 2 (50%) 2 (40%) Preputial Gland (8) (6) (8) (2) (3) (9) Inflammation, Chronic Active 6 (75%) 2 (33%) 5 (63%) 1 (50%) 3 (100%) 7 (78%) Inflammation, Suppurative 1 (13%) Prostate (2) (1) (2) Inflammation, Suppurative 2 (100%) 1 (100%) 2 (100%) Testes (20) (9) (24) (25) (19) (13) Atrophy 6 (30%) 1 (11%) 1 (4%) 5 (20%) 1 (5%) 3 (23%) Necrosis 1 (4%) Interstitial Cell, Hyperplasia 2 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (9) (7) (10) (10) (17) (26) Hyperplasia, Lymphoid 1 (10%) Infiltration Cellular, Plasma Cell 1 (11%) Pigmentation 1 (10%) Iliac, Infiltration Cellular, Plasma Cell 1 (11%) 1 (6%) Iliac, Pigmentation 1 (6%) Pancreatic, Hyperplasia, Lymphoid 1 (10%) Pancreatic, Inflammation, Granulomatous 1 (11%) 1 (4%) Renal, Hemorrhage 1 (11%) 1 (10%) 1 (10%) 3 (12%) Renal, Hyperplasia, Lymphoid 1 (10%) Renal, Infiltration Cellular, Plasma Cell 4 (44%) 1 (14%) 1 (10%) 1 (6%) 5 (19%) Renal, Inflammation, Granulomatous 1 (11%) 2 (29%) 1 (10%) 1 (6%) 1 (4%) Lymph Node, Bronchial (38) (32) (23) (26) (30) (28) Hemorrhage 1 (3%) 1 (3%) 1 (4%) 2 (8%) Hyperplasia, Lymphoid 2 (5%) 1 (4%) Necrosis 1 (3%) Lymph Node, Mandibular (4) (8) (7) (7) (15) (14) Hyperplasia, Lymphoid 1 (7%) Infiltration Cellular, Plasma Cell 5 (71%) 1 (14%) 1 (7%) 3 (21%) Necrosis 1 (7%) Lymph Node, Mesenteric (2) (8) (3) (11) (8) (9) Hyperplasia, Lymphoid 1 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Inflammation, Granulomatous 1 (13%) 1 (9%) Lymph Node, Mediastinal (42) (37) (43) (43) (43) (45) Fibrosis 1 (2%) Hemorrhage 2 (5%) 1 (3%) 3 (7%) 2 (5%) 2 (4%) Infiltration Cellular, Plasma Cell 2 (5%) 1 (3%) 2 (5%) 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) Necrosis 1 (3%) 1 (2%) Spleen (35) (32) (33) (37) (39) (39) Accessory Spleen 1 (3%) 1 (3%) 1 (3%) 4 (10%) Atrophy 1 (3%) Congestion 2 (6%) 2 (6%) 1 (3%) Fibrosis 12 (34%) 14 (44%) 7 (21%) 12 (32%) 13 (33%) 10 (26%) Hematopoietic Cell Proliferation 1 (3%) 1 (3%) 1 (3%) 1 (3%) 1 (3%) Hemorrhage 2 (6%) Necrosis 1 (3%) 1 (3%) 1 (3%) 3 (8%) Capsule, Fibrosis 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (4) (5) (2) (4) (5) Galactocele 2 (50%) 3 (60%) 2 (100%) 2 (50%) 4 (80%) Hyperplasia 1 (25%) 2 (40%) 1 (25%) 1 (20%) Inflammation, Chronic 1 (20%) 1 (20%) Skin (47) (47) (48) (48) (48) (47) Hyperkeratosis 2 (4%) 1 (2%) 2 (4%) 3 (6%) Hyperplasia 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 1 (2%) 2 (4%) Inflammation, Suppurative 1 (2%) 1 (2%) Ulcer 2 (4%) 1 (2%) Dermis, Cyst 1 (2%) 1 (2%) Prepuce, Inflammation, Suppurative 1 (2%) 3 (6%) 3 (6%) 2 (4%) 1 (2%) Sebaceous Gland, Hyperplasia 1 (2%) Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%) Subcutaneous Tissue, Necrosis 1 (2%) Subcutaneous Tissue, Skin, Site of Application, Inflammation, Chronic 46 (98%) 47 (100%) 48 (100%) 47 (98%) 48 (100%) 47 (100%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (2) (1) Hemorrhage 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (48) (48) (48) (48) (48) (48) Foreign Body 3 (6%) 2 (4%) 2 (4%) Inflammation, Suppurative 1 (2%) 4 (8%) 3 (6%) 3 (6%) 6 (13%) Metaplasia, Squamous 1 (2%) Mineralization 1 (2%) 1 (2%) Lung (48) (48) (48) (48) (48) (48) Congestion 2 (4%) 2 (4%) 5 (10%) 3 (6%) Edema 1 (2%) 3 (6%) 1 (2%) Fibrosis, Focal 2 (4%) 1 (2%) 1 (2%) Hemorrhage 3 (6%) 2 (4%) 2 (4%) 1 (2%) 3 (6%) 5 (10%) Mineralization 4 (8%) 2 (4%) Alveolar Epithelium, Hyperplasia 1 (2%) Alveolar Epithelium, Hyperplasia, Atypical 10 (21%) 12 (25%) 33 (69%) 39 (81%) Alveolar Epithelium, Metaplasia 35 (73%) 47 (98%) 45 (94%) Alveolus, Infiltration Cellular, Focal, Histiocyte 1 (2%) 1 (2%) Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 7 (15%) 9 (19%) 13 (27%) 8 (17%) Bronchus, Inflammation, Suppurative 1 (2%) Interstitium, Fibrosis 34 (71%) 46 (96%) 45 (94%) Interstitium, Inflammation, Chronic, Diffuse 3 (6%) 1 (2%) 2 (4%) Perivascular, Inflammation, Chronic 1 (2%) Serosa, Fibrosis 1 (2%) Serosa, Inflammation, Chronic Active 1 (2%) Nose (47) (48) (48) (48) (46) (48) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) 3 (6%) 3 (6%) 1 (2%) 5 (10%) Thrombosis 1 (2%) Goblet Cell, Lateral Wall, Hyperplasia 3 (6%) 38 (79%) 45 (94%) 42 (91%) 3 (6%) Lateral Wall, Hyperplasia 5 (11%) 4 (8%) 46 (96%) 48 (100%) 46 (100%) 5 (10%) Nasopharyngeal Duct, Infiltration Cellular, Mixed Cell 1 (2%) Olfactory Epithelium, Degeneration, Hyaline 47 (100%) 48 (100%) 47 (98%) 48 (100%) 46 (100%) 45 (94%) Olfactory Epithelium, Metaplasia 1 (2%) 4 (8%) 1 (2%) 1 (2%) 2 (4%) Turbinate, Necrosis 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88034-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC OZONE/NNK Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:01:31 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE TRIOCT./ .1MG/KG TRIOCT./ .1M/KNNK 1M/K NNK 1 MG/KG AIR NNK/AIR OZONE /OZONE /OZONE NNK/AIR ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (1) (4) (1) Cataract 3 (100%) 1 (100%) 2 (50%) 1 (100%) Hemorrhage 1 (33%) 1 (25%) Ciliary Body, Retina, Degeneration 2 (67%) 1 (100%) 2 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (27) (22) (15) (20) (25) (24) Cyst 1 (4%) 2 (13%) 1 (4%) Hydronephrosis 1 (4%) Infarct 1 (5%) 1 (4%) 2 (8%) Nephropathy 27 (100%) 22 (100%) 14 (93%) 18 (90%) 22 (88%) 22 (92%) Pigmentation, Hemosiderin 1 (5%) Urinary Bladder (2) (2) (3) (1) (1) Calculus Gross Observation 1 (50%) Calculus Micro Observation Only 1 (50%) 1 (100%) Hemorrhage 1 (50%) 2 (67%) 1 (100%) Inflammation, Chronic Active 1 (50%) Inflammation, Suppurative 1 (100%) Transitional Epithelium, Necrosis 1 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------